NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767926404|ref|XP_011510992|]
View 

zinc finger and BTB domain-containing protein 11 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
BTB_POZ super family cl38908
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 1-28 1.57e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


The actual alignment was detected with superfamily member cd18202:

Pssm-ID: 453885 [Multi-domain]  Cd Length: 118  Bit Score: 56.40  E-value: 1.57e-09
                         10        20
                 ....*....|....*....|....*...
gi 767926404   1 MADVAILARHLFMSEVLEICESVHKLME 28
Cdd:cd18202   91 MAEVAMLARHLFMNEVLEICESVHKQME 118
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 386-473 8.05e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.86  E-value: 8.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926404 386 MLKHTGVKPHACQV--CGKTFIYKHGLKLHQSL-HQSQKqfqcelcvksfVTKRSLQEHMSIHTGESK-YLCSVCGKSFH 461
Cdd:COG5189  341 MLKVKDGKPYKCPVegCNKKYKNQNGLKYHMLHgHQNQK-----------LHENPSPEKMNIFSAKDKpYRCEVCDKRYK 409

                         90
                 ....*....|..
gi 767926404 462 RGSGLSKHfKKH 473
Cdd:COG5189  410 NLNGLKYH-RKH 420
zf-H2C2_2 pfam13465
Zinc-finger double domain;
616-639 9.37e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 9.37e-05
                          10        20
                  ....*....|....*....|....
gi 767926404  616 SLKRHVRTHTGERPYVCPVCSEAY 639
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
496-520 8.77e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 8.77e-04
                          10        20
                  ....*....|....*....|....*
gi 767926404  496 DLRQHMNKHLGVKPFQCQFCDKCYS 520
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
PRK12387 super family cl32760
formate hydrogenlyase complex iron-sulfur subunit; Provisional
 273-338 4.65e-03

formate hydrogenlyase complex iron-sulfur subunit; Provisional


The actual alignment was detected with superfamily member PRK12387:

Pssm-ID: 183492 [Multi-domain]  Cd Length: 180  Bit Score: 38.86  E-value: 4.65e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767926404 273 KRDAKENTEEASHKCGECGMVF--QRRYALIMHKLKH------ERARDY--KCPLCKKQFQYSASLRAHLIRHTRK 338
Cdd:PRK12387 103 KEDLLQQSEFALCNCRVCGRPFavQKEIDYAIALLKHngdsraENHRESfeTCPECKRQKCLVPSDRIELTRHMKE 178
 
Name Accession Description Interval E-value
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-28 1.57e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 56.40  E-value: 1.57e-09
                         10        20
                 ....*....|....*....|....*...
gi 767926404   1 MADVAILARHLFMSEVLEICESVHKLME 28
Cdd:cd18202   91 MAEVAMLARHLFMNEVLEICESVHKQME 118
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 386-473 8.05e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.86  E-value: 8.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926404 386 MLKHTGVKPHACQV--CGKTFIYKHGLKLHQSL-HQSQKqfqcelcvksfVTKRSLQEHMSIHTGESK-YLCSVCGKSFH 461
Cdd:COG5189  341 MLKVKDGKPYKCPVegCNKKYKNQNGLKYHMLHgHQNQK-----------LHENPSPEKMNIFSAKDKpYRCEVCDKRYK 409

                         90
                 ....*....|..
gi 767926404 462 RGSGLSKHfKKH 473
Cdd:COG5189  410 NLNGLKYH-RKH 420
zf-H2C2_2 pfam13465
Zinc-finger double domain;
616-639 9.37e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 9.37e-05
                          10        20
                  ....*....|....*....|....
gi 767926404  616 SLKRHVRTHTGERPYVCPVCSEAY 639
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
381-406 3.92e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.92e-04
                          10        20
                  ....*....|....*....|....*.
gi 767926404  381 SLRIHMLKHTGVKPHACQVCGKTFIY 406
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
496-520 8.77e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 8.77e-04
                          10        20
                  ....*....|....*....|....*
gi 767926404  496 DLRQHMNKHLGVKPFQCQFCDKCYS 520
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
PRK12387 PRK12387
formate hydrogenlyase complex iron-sulfur subunit; Provisional
 273-338 4.65e-03

formate hydrogenlyase complex iron-sulfur subunit; Provisional


Pssm-ID: 183492 [Multi-domain]  Cd Length: 180  Bit Score: 38.86  E-value: 4.65e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767926404 273 KRDAKENTEEASHKCGECGMVF--QRRYALIMHKLKH------ERARDY--KCPLCKKQFQYSASLRAHLIRHTRK 338
Cdd:PRK12387 103 KEDLLQQSEFALCNCRVCGRPFavQKEIDYAIALLKHngdsraENHRESfeTCPECKRQKCLVPSDRIELTRHMKE 178
 
Name Accession Description Interval E-value
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-28 1.57e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 56.40  E-value: 1.57e-09
                         10        20
                 ....*....|....*....|....*...
gi 767926404   1 MADVAILARHLFMSEVLEICESVHKLME 28
Cdd:cd18202   91 MAEVAMLARHLFMNEVLEICESVHKQME 118
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 386-473 8.05e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.86  E-value: 8.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926404 386 MLKHTGVKPHACQV--CGKTFIYKHGLKLHQSL-HQSQKqfqcelcvksfVTKRSLQEHMSIHTGESK-YLCSVCGKSFH 461
Cdd:COG5189  341 MLKVKDGKPYKCPVegCNKKYKNQNGLKYHMLHgHQNQK-----------LHENPSPEKMNIFSAKDKpYRCEVCDKRYK 409

                         90
                 ....*....|..
gi 767926404 462 RGSGLSKHfKKH 473
Cdd:COG5189  410 NLNGLKYH-RKH 420
zf-H2C2_2 pfam13465
Zinc-finger double domain;
616-639 9.37e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 9.37e-05
                          10        20
                  ....*....|....*....|....
gi 767926404  616 SLKRHVRTHTGERPYVCPVCSEAY 639
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
383-556 3.29e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 3.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926404 383 RIHMLKHTG-VKPHACQVCGKTFIYKHGLKLHQ--SLH--QSQKQFQC--ELCVKSFVTKRSLQEHMSIHTG--ESKYLC 453
Cdd:COG5048  277 ESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHsgESLKPFSCpySLCGKLFSRNDALKRHILLHTSisPAKEKL 356

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926404 454 SVCGKSFHRGSGlSKHFKKHQPKPEVRGYHCTQCEKSFFEARDLRQ-----HMNKHLGVKPFQCQF--CDKCYSWKKDWY 526
Cdd:COG5048  357 LNSSSKFSPLLN-NEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDsnlslHIITHLSFRPYNCKNppCSKSFNRHYNLI 435

                        170       180       190
                 ....*....|....*....|....*....|
gi 767926404 527 SHVKSHSVTEPYRCNICGKEFYEKALFRRH 556
Cdd:COG5048  436 PHKKIHTNHAPLLCSILKSFRRDLDLSNHG 465
zf-H2C2_2 pfam13465
Zinc-finger double domain;
381-406 3.92e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.92e-04
                          10        20
                  ....*....|....*....|....*.
gi 767926404  381 SLRIHMLKHTGVKPHACQVCGKTFIY 406
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
496-520 8.77e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 8.77e-04
                          10        20
                  ....*....|....*....|....*
gi 767926404  496 DLRQHMNKHLGVKPFQCQFCDKCYS 520
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
437-460 1.49e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.49e-03
                          10        20
                  ....*....|....*....|....
gi 767926404  437 SLQEHMSIHTGESKYLCSVCGKSF 460
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
412-477 3.68e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 3.68e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767926404 412 LHQSLHQSQKQFQCELCVKSFVTKRSLQEHMSIHTGESKYLCSV--CGKSFHRGSGLSKHFKKHQPKP 477
Cdd:COG5048   23 TLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNP 90
PRK12387 PRK12387
formate hydrogenlyase complex iron-sulfur subunit; Provisional
 273-338 4.65e-03

formate hydrogenlyase complex iron-sulfur subunit; Provisional


Pssm-ID: 183492 [Multi-domain]  Cd Length: 180  Bit Score: 38.86  E-value: 4.65e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767926404 273 KRDAKENTEEASHKCGECGMVF--QRRYALIMHKLKH------ERARDY--KCPLCKKQFQYSASLRAHLIRHTRK 338
Cdd:PRK12387 103 KEDLLQQSEFALCNCRVCGRPFavQKEIDYAIALLKHngdsraENHRESfeTCPECKRQKCLVPSDRIELTRHMKE 178
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
365-500 9.16e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 9.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926404 365 REFIC--SICGRTLPKLYSLRIHMLKHTGVKPHACQVCGKTFIYKHGL--KLHQSLHQSQ-----KQFQCEL--CVKSFV 433
Cdd:COG5048  320 KPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLnnEPPQSLQQYKdlkndKKSETLSnsCIRNFK 399

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767926404 434 TKRSLQEHMSIHTGESKYLCsvcgKSFHRGSGLSKH-FKKHQPKPEVRG-YHCTQCEKSFFEARDLRQH 500
Cdd:COG5048  400 RDSNLSLHIITHLSFRPYNC----KNPPCSKSFNRHyNLIPHKKIHTNHaPLLCSILKSFRRDLDLSNH 464
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH