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Conserved domains on  [gi|767917277|ref|XP_005247049|]
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cysteine protease ATG4B isoform X1 [Homo sapiens]

Protein Classification

cysteine protease ATG4( domain architecture ID 10506323)

cysteine protease ATG4 is required in the cytoplasm for vacuole transport (Cvt) and autophagy

EC:  3.4.22.-
MEROPS:  C54
PubMed:  11517925

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Peptidase_C54 pfam03416
Peptidase family C54;
39-335 1.28e-167

Peptidase family C54;


:

Pssm-ID: 460915  Cd Length: 269  Bit Score: 470.45  E-value: 1.28e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917277   39 KDEILSDVASRLWFTYRKNFPAIGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFIDR 118
Cdd:pfam03416   1 PEEFLDDFESRIWFTYRKGFPPIGGSGFTSDTGWGCMLRSGQMLLAQALLRHHLGRDWRWGDPDEEEETYRKILSWFADD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917277  119 KDSYYSIHQIAQMGV-GEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIRRLCRTSvpcagatafpa 197
Cdd:pfam03416  81 PSAPFSIHQIVQMGKeSSGKKPGEWFGPSTVAQILKKLVNADPWSGLAVYVASDGTVYKDDVRKLCAPN----------- 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917277  198 dsdrhcngfpagaevtNRPSPWRPLVLLIPLRLGLTDINEAYVETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYL 277
Cdd:pfam03416 150 ----------------SASSGEKPLLILVPLRLGLDKINPVYIPALKALLSLPQSVGIIGGRPSSSLYFVGFQGDKLIYL 213
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 767917277  278 DPHTTQPAVEPTDGCFiPDESFHCQHpPCRMSIAELDPSIAVGFFCKTEDDFNDWCQQ 335
Cdd:pfam03416 214 DPHTTQPAVDVSYTDF-DLESYHCKR-PRKMPISKMDPSMALGFYCRDEEDFEDFCSR 269
 
Name Accession Description Interval E-value
Peptidase_C54 pfam03416
Peptidase family C54;
39-335 1.28e-167

Peptidase family C54;


Pssm-ID: 460915  Cd Length: 269  Bit Score: 470.45  E-value: 1.28e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917277   39 KDEILSDVASRLWFTYRKNFPAIGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFIDR 118
Cdd:pfam03416   1 PEEFLDDFESRIWFTYRKGFPPIGGSGFTSDTGWGCMLRSGQMLLAQALLRHHLGRDWRWGDPDEEEETYRKILSWFADD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917277  119 KDSYYSIHQIAQMGV-GEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIRRLCRTSvpcagatafpa 197
Cdd:pfam03416  81 PSAPFSIHQIVQMGKeSSGKKPGEWFGPSTVAQILKKLVNADPWSGLAVYVASDGTVYKDDVRKLCAPN----------- 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917277  198 dsdrhcngfpagaevtNRPSPWRPLVLLIPLRLGLTDINEAYVETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYL 277
Cdd:pfam03416 150 ----------------SASSGEKPLLILVPLRLGLDKINPVYIPALKALLSLPQSVGIIGGRPSSSLYFVGFQGDKLIYL 213
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 767917277  278 DPHTTQPAVEPTDGCFiPDESFHCQHpPCRMSIAELDPSIAVGFFCKTEDDFNDWCQQ 335
Cdd:pfam03416 214 DPHTTQPAVDVSYTDF-DLESYHCKR-PRKMPISKMDPSMALGFYCRDEEDFEDFCSR 269
 
Name Accession Description Interval E-value
Peptidase_C54 pfam03416
Peptidase family C54;
39-335 1.28e-167

Peptidase family C54;


Pssm-ID: 460915  Cd Length: 269  Bit Score: 470.45  E-value: 1.28e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917277   39 KDEILSDVASRLWFTYRKNFPAIGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFIDR 118
Cdd:pfam03416   1 PEEFLDDFESRIWFTYRKGFPPIGGSGFTSDTGWGCMLRSGQMLLAQALLRHHLGRDWRWGDPDEEEETYRKILSWFADD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917277  119 KDSYYSIHQIAQMGV-GEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIRRLCRTSvpcagatafpa 197
Cdd:pfam03416  81 PSAPFSIHQIVQMGKeSSGKKPGEWFGPSTVAQILKKLVNADPWSGLAVYVASDGTVYKDDVRKLCAPN----------- 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917277  198 dsdrhcngfpagaevtNRPSPWRPLVLLIPLRLGLTDINEAYVETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYL 277
Cdd:pfam03416 150 ----------------SASSGEKPLLILVPLRLGLDKINPVYIPALKALLSLPQSVGIIGGRPSSSLYFVGFQGDKLIYL 213
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 767917277  278 DPHTTQPAVEPTDGCFiPDESFHCQHpPCRMSIAELDPSIAVGFFCKTEDDFNDWCQQ 335
Cdd:pfam03416 214 DPHTTQPAVDVSYTDF-DLESYHCKR-PRKMPISKMDPSMALGFYCRDEEDFEDFCSR 269
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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