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Conserved domains on  [gi|767910684|ref|XP_011508377|]
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protein dispatched homolog 1 isoform X1 [Homo sapiens]

Protein Classification

RND transporter family protein( domain architecture ID 1001856)

resistance-nodulation-cell division (RND) transporter family protein

Gene Ontology:  GO:0016020|GO:0055085
PubMed:  10941792
TCDB:  2.A.6

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MMPL super family cl34072
Predicted exporter protein, RND superfamily [General function prediction only];
496-1127 4.61e-43

Predicted exporter protein, RND superfamily [General function prediction only];


The actual alignment was detected with superfamily member COG1033:

Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 170.04  E-value: 4.61e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684  496 FQDYLLMD-TVYPAIAIVIVLLVMCVYTKSMFITLMTMFAIISSLIVSY-FLYrvVFHFEFFPFMNLTALIILvGIGADD 573
Cdd:COG1033   212 IAEAIQSDlAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLgLMG--LLGIPLSPLTILVPPLLL-AIGIDY 288

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684  574 AFVLcdVWNYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLP 653
Cdd:COG1033   289 GIHL--LNRYREERRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLP 366

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684  654 AVVVLheryllniftcFKKPQQQiydnkscwtvacqkcHKVLFAISEASRIFfeKVLPCIVIKFRYLWLFWFLALTVGGA 733
Cdd:COG1033   367 ALLSL-----------LPRPKPK---------------TRRLKKPPELGRLL--AKLARFVLRRPKVILVVALVLAVVSL 418

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684  734 YIVcinPKMKLPSLELSEfqvFRSSHPFeRYDAEYkklfmFERVHHGEelhMPITVIwgvspedngnplnpkskgkLTLD 813
Cdd:COG1033   419 YGI---SRLKVEYDFEDY---LPEDSPI-RQDLDF-----IEENFGGS---DPLEVV-------------------VDTG 464

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684  814 SSFNIASPASQAWILHFCQKLRNQTFFYQTdeQDFTScFIETFKQWMENQDCDEPALypccshwsfPYKQEIFELcikra 893
Cdd:COG1033   465 EPDGLKDPEVLKEIDRLQDYLESLPEVGKV--LSLAD-LVKELNQALNEGDPKYYAL---------PESRELLAQ----- 527

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684  894 imelerstGYHLDSKTPGPRFD--INDTIRAVVLefqSTYLFTLAYEKMHQFYKEVDSWISSELssAPEGLSngWFVS-- 969
Cdd:COG1033   528 --------LLLLLSSPPGDDLSrfVDEDYSAARV---TVRLKDLDSEEIKALVEEVRAFLAENF--PPDGVE--VTLTgs 592

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684  970 NLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLS 1049
Cdd:COG1033   593 AVLFAAINESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIG 672

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684 1050 VDFAVHYGVAYR--LAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCISWAFATFFF 1127
Cdd:COG1033   673 VDYTIHFLSRYReeRRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLL 752
 
Name Accession Description Interval E-value
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
496-1127 4.61e-43

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 170.04  E-value: 4.61e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684  496 FQDYLLMD-TVYPAIAIVIVLLVMCVYTKSMFITLMTMFAIISSLIVSY-FLYrvVFHFEFFPFMNLTALIILvGIGADD 573
Cdd:COG1033   212 IAEAIQSDlAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLgLMG--LLGIPLSPLTILVPPLLL-AIGIDY 288

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684  574 AFVLcdVWNYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLP 653
Cdd:COG1033   289 GIHL--LNRYREERRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLP 366

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684  654 AVVVLheryllniftcFKKPQQQiydnkscwtvacqkcHKVLFAISEASRIFfeKVLPCIVIKFRYLWLFWFLALTVGGA 733
Cdd:COG1033   367 ALLSL-----------LPRPKPK---------------TRRLKKPPELGRLL--AKLARFVLRRPKVILVVALVLAVVSL 418

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684  734 YIVcinPKMKLPSLELSEfqvFRSSHPFeRYDAEYkklfmFERVHHGEelhMPITVIwgvspedngnplnpkskgkLTLD 813
Cdd:COG1033   419 YGI---SRLKVEYDFEDY---LPEDSPI-RQDLDF-----IEENFGGS---DPLEVV-------------------VDTG 464

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684  814 SSFNIASPASQAWILHFCQKLRNQTFFYQTdeQDFTScFIETFKQWMENQDCDEPALypccshwsfPYKQEIFELcikra 893
Cdd:COG1033   465 EPDGLKDPEVLKEIDRLQDYLESLPEVGKV--LSLAD-LVKELNQALNEGDPKYYAL---------PESRELLAQ----- 527

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684  894 imelerstGYHLDSKTPGPRFD--INDTIRAVVLefqSTYLFTLAYEKMHQFYKEVDSWISSELssAPEGLSngWFVS-- 969
Cdd:COG1033   528 --------LLLLLSSPPGDDLSrfVDEDYSAARV---TVRLKDLDSEEIKALVEEVRAFLAENF--PPDGVE--VTLTgs 592

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684  970 NLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLS 1049
Cdd:COG1033   593 AVLFAAINESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIG 672

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684 1050 VDFAVHYGVAYR--LAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCISWAFATFFF 1127
Cdd:COG1033   673 VDYTIHFLSRYReeRRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLL 752
Patched pfam02460
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
 435-1131 2.39e-27

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 120.54  E-value: 2.39e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684   435 DFMTPKTADYATPALKYSMLFSPTEKGESMMNIYLDNFENWnsSDGVTTITGIEFGIKHSLFQDYLLM---DTVYPAIAI 511
Cdd:pfam02460  144 DFEPPGNISYAKAIVLWYFLKFDEEEVEEDSKEWEDELSQL--LHNKYASEHIQFTIFHDQILNDELVrnaLTLTPFFVI 221

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684   512 VIVLLVM-----CVYTKSMFITLMT------MFAIISSL--IVSYFLYRVVFHFEFFPFMNLTALIILvGIGADDAFVLC 578
Cdd:pfam02460  222 GFFLLLTfsiivSVTLSSYTIDWVRskpilaALGLLSPVmaIVSSFGLLFWMGFPFNSIVCVTPFLVL-AIGVDDMFLMV 300

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684   579 DVWNYTKfdkPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVL 658
Cdd:pfam02460  301 AAWQRTT---ATLSVKKRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAI 377

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684   659 HERYLLN----IFTCFKKPQQQIYDNKScwtvACQKCHKVlfaISEASRIFFEKVLPCIV-IKFRYLWLFWF---LALTV 730
Cdd:pfam02460  378 CAKPEAEgrhcLFVWATSSPQRIDSEGS----EPDKSHNI---EQLKSRFFLDIYCPFLLnPSVRVCMLVLFvvyIAIAI 450

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684   731 GGayivCINPKMklpslELSEFQVFRSSHPFerydAEYKKLFMFERVHHGEELHMPITviwgvSPEDNGNPLNPKSKGKL 810
Cdd:pfam02460  451 YG----CVNIKE-----GLEPDKLVLEDSPL----VEYLSLREKHFWPEGLQIQVAVN-----NPPNLTIPESRDRMNEM 512

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684   811 TLD---SSFNIASPASQAWILHFCQKLRNQTFFYQTDEQDftSCFIETFKQWMEnqdcdepalYPCCSHWSfpykqeife 887
Cdd:pfam02460  513 VDEfenTPYSLGPNSTLFWLREYENFLSTLNMEEEEDEEK--EWSYGNLPSFLK---------APGNSHWA--------- 572

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684   888 lcikraimelerstGYHLdsktpgprFDINDTIravvlefQSTYLFTLAYEKMHQFYKEVDSW--ISSELSSAPEgLSNG 965
Cdd:pfam02460  573 --------------GDLV--------WDDNTTM-------VTKFRFTLAGKGLSTWNDRTRALqeWRSIADQYPE-FNVT 622

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684   966 WFVSNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVA 1045
Cdd:pfam02460  623 VFDEDAPFADQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMS 702

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684  1046 VGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRVGSAMAMAALTTFVagAMMMPSTVLAYTQLGTF--MMLIMCISWAFA 1123
Cdd:pfam02460  703 IGFSVDFSAHIAYHFVRSRGDTPAERVVDALEALGWPVFQGGLSTIL--GVLVLLFVPSYMVVVFFktVFLVVAIGLLHG 780

                          730
                   ....*....|.
gi 767910684  1124 TFF---FQCMC 1131
Cdd:pfam02460  781 LFIlpiILSLF 791
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
 979-1125 1.31e-09

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 63.09  E-value: 1.31e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684   979 SLSDGTLIAMGLSvavaFSVMLLTTWNIIISLYAIISIAGTIFVtvGSLVLLGWELNVLESVT-ISVA-----VGLSVDF 1052
Cdd:TIGR03480  266 TVSEGATVAGLLS----FVLVLVLLWLALRSPRLVFAVLVTLIV--GLILTAAFATLAVGHLNlISVAfavlfIGLGVDF 339

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767910684  1053 AVHYGVAYR--LAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCISWaFATF 1125
Cdd:TIGR03480  340 AIQFSLRYReeRFRGGNHREALSVAARRMGAALLLAALATAAGFFAFLPTDYKGVSELGIIAGTGMFIAL-FVTL 413
MATE_like_8 cd13134
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 985-1124 2.90e-03

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240539 [Multi-domain]  Cd Length: 438  Bit Score: 42.10  E-value: 2.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684  985 LIAMGLSVAVAFSVMLLTTWNIIISLYA-IISIAGTifvtvgSLVLLGWE-LNVLE------SVTISVAVGLSVDFAVHY 1056
Cdd:cd13134   134 LQALSLTLSAILRSHGRTKIPMYVSLIMnILNIVGN------YLLIFGWFgLPKLGvagvaiSTVISRAVGLVLLFILLF 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684 1057 ---GVAYRLAPDPDREGKVIFSLSRVG--SA-------MAMAALTTFVAgamMMPSTVLA-YTQLGTFMMLIMCISWAFA 1123
Cdd:cd13134   208 rklKIRFRLKDLRPFPKKLLKKILKIGlpSAgeelsynLSQTVITAFIA---RLGTAALAaRTYASNISMFVFLFSLAIG 284


                  .
gi 767910684 1124 T 1124
Cdd:cd13134   285 Q 285
 
Name Accession Description Interval E-value
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
496-1127 4.61e-43

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 170.04  E-value: 4.61e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684  496 FQDYLLMD-TVYPAIAIVIVLLVMCVYTKSMFITLMTMFAIISSLIVSY-FLYrvVFHFEFFPFMNLTALIILvGIGADD 573
Cdd:COG1033   212 IAEAIQSDlAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLgLMG--LLGIPLSPLTILVPPLLL-AIGIDY 288

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684  574 AFVLcdVWNYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLP 653
Cdd:COG1033   289 GIHL--LNRYREERRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLP 366

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684  654 AVVVLheryllniftcFKKPQQQiydnkscwtvacqkcHKVLFAISEASRIFfeKVLPCIVIKFRYLWLFWFLALTVGGA 733
Cdd:COG1033   367 ALLSL-----------LPRPKPK---------------TRRLKKPPELGRLL--AKLARFVLRRPKVILVVALVLAVVSL 418

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684  734 YIVcinPKMKLPSLELSEfqvFRSSHPFeRYDAEYkklfmFERVHHGEelhMPITVIwgvspedngnplnpkskgkLTLD 813
Cdd:COG1033   419 YGI---SRLKVEYDFEDY---LPEDSPI-RQDLDF-----IEENFGGS---DPLEVV-------------------VDTG 464

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684  814 SSFNIASPASQAWILHFCQKLRNQTFFYQTdeQDFTScFIETFKQWMENQDCDEPALypccshwsfPYKQEIFELcikra 893
Cdd:COG1033   465 EPDGLKDPEVLKEIDRLQDYLESLPEVGKV--LSLAD-LVKELNQALNEGDPKYYAL---------PESRELLAQ----- 527

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684  894 imelerstGYHLDSKTPGPRFD--INDTIRAVVLefqSTYLFTLAYEKMHQFYKEVDSWISSELssAPEGLSngWFVS-- 969
Cdd:COG1033   528 --------LLLLLSSPPGDDLSrfVDEDYSAARV---TVRLKDLDSEEIKALVEEVRAFLAENF--PPDGVE--VTLTgs 592

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684  970 NLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLS 1049
Cdd:COG1033   593 AVLFAAINESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIG 672

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684 1050 VDFAVHYGVAYR--LAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCISWAFATFFF 1127
Cdd:COG1033   673 VDYTIHFLSRYReeRRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLL 752
Patched pfam02460
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
 435-1131 2.39e-27

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 120.54  E-value: 2.39e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684   435 DFMTPKTADYATPALKYSMLFSPTEKGESMMNIYLDNFENWnsSDGVTTITGIEFGIKHSLFQDYLLM---DTVYPAIAI 511
Cdd:pfam02460  144 DFEPPGNISYAKAIVLWYFLKFDEEEVEEDSKEWEDELSQL--LHNKYASEHIQFTIFHDQILNDELVrnaLTLTPFFVI 221

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684   512 VIVLLVM-----CVYTKSMFITLMT------MFAIISSL--IVSYFLYRVVFHFEFFPFMNLTALIILvGIGADDAFVLC 578
Cdd:pfam02460  222 GFFLLLTfsiivSVTLSSYTIDWVRskpilaALGLLSPVmaIVSSFGLLFWMGFPFNSIVCVTPFLVL-AIGVDDMFLMV 300

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684   579 DVWNYTKfdkPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVL 658
Cdd:pfam02460  301 AAWQRTT---ATLSVKKRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAI 377

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684   659 HERYLLN----IFTCFKKPQQQIYDNKScwtvACQKCHKVlfaISEASRIFFEKVLPCIV-IKFRYLWLFWF---LALTV 730
Cdd:pfam02460  378 CAKPEAEgrhcLFVWATSSPQRIDSEGS----EPDKSHNI---EQLKSRFFLDIYCPFLLnPSVRVCMLVLFvvyIAIAI 450

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684   731 GGayivCINPKMklpslELSEFQVFRSSHPFerydAEYKKLFMFERVHHGEELHMPITviwgvSPEDNGNPLNPKSKGKL 810
Cdd:pfam02460  451 YG----CVNIKE-----GLEPDKLVLEDSPL----VEYLSLREKHFWPEGLQIQVAVN-----NPPNLTIPESRDRMNEM 512

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684   811 TLD---SSFNIASPASQAWILHFCQKLRNQTFFYQTDEQDftSCFIETFKQWMEnqdcdepalYPCCSHWSfpykqeife 887
Cdd:pfam02460  513 VDEfenTPYSLGPNSTLFWLREYENFLSTLNMEEEEDEEK--EWSYGNLPSFLK---------APGNSHWA--------- 572

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684   888 lcikraimelerstGYHLdsktpgprFDINDTIravvlefQSTYLFTLAYEKMHQFYKEVDSW--ISSELSSAPEgLSNG 965
Cdd:pfam02460  573 --------------GDLV--------WDDNTTM-------VTKFRFTLAGKGLSTWNDRTRALqeWRSIADQYPE-FNVT 622

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684   966 WFVSNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVA 1045
Cdd:pfam02460  623 VFDEDAPFADQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMS 702

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684  1046 VGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRVGSAMAMAALTTFVagAMMMPSTVLAYTQLGTF--MMLIMCISWAFA 1123
Cdd:pfam02460  703 IGFSVDFSAHIAYHFVRSRGDTPAERVVDALEALGWPVFQGGLSTIL--GVLVLLFVPSYMVVVFFktVFLVVAIGLLHG 780

                          730
                   ....*....|.
gi 767910684  1124 TFF---FQCMC 1131
Cdd:pfam02460  781 LFIlpiILSLF 791
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
974-1127 2.21e-16

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 84.91  E-value: 2.21e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684  974 YDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFA 1053
Cdd:COG1033   210 GDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTILVPPLLLAIGIDYG 289

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767910684 1054 VHYGVAYR--LAPDPDREGKVIFSLSRVGSAMAMAALTTFVA-GAMM-MPSTVLAytQLGTFMMLIMCISWAFATFFF 1127
Cdd:COG1033   290 IHLLNRYReeRRKGLDKREALREALRKLGPPVLLTSLTTAIGfLSLLfSDIPPIR--DFGIVAAIGVLLAFLTSLTLL 365
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
508-662 8.37e-15

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 79.90  E-value: 8.37e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684  508 AIAIVIVLLVMCVYTKSMFITLMTMFAIISSLIVSY-FLYrvVFHFEFFPfMNLTALIILVGIGADDAFVLcdVWNYTKF 586
Cdd:COG1033   612 LLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFgLMG--LLGIPLNI-ATAVVASIALGIGVDYTIHF--LSRYREE 686

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767910684  587 DKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVLHERY 662
Cdd:COG1033   687 RRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLLLDPR 762
Sterol-sensing pfam12349
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ...
 507-671 8.97e-14

Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.


Pssm-ID: 463544 [Multi-domain]  Cd Length: 153  Bit Score: 70.30  E-value: 8.97e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684   507 PAIAIVIVLLVMCVYTKSMfiTLMTMFAIISSLIVSyflyrvvfhfEFFPFmnltaliILVGIGADDAFVLCDVWNYTKF 586
Cdd:pfam12349    6 FGLGLAGVIIVLASVASSL--GLCAYFGLPLTLIIS----------EVIPF-------LVLAIGVDNIFLLVKAVVRTPR 66

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684   587 DKPhaeTSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVLHER----Y 662
Cdd:pfam12349   67 SLD---VSERIAEALGEVGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRrlesN 143


                   ....*....
gi 767910684   663 LLNIFTCFK 671
Cdd:pfam12349  144 RLDVACCIR 152
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
 979-1125 1.31e-09

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 63.09  E-value: 1.31e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684   979 SLSDGTLIAMGLSvavaFSVMLLTTWNIIISLYAIISIAGTIFVtvGSLVLLGWELNVLESVT-ISVA-----VGLSVDF 1052
Cdd:TIGR03480  266 TVSEGATVAGLLS----FVLVLVLLWLALRSPRLVFAVLVTLIV--GLILTAAFATLAVGHLNlISVAfavlfIGLGVDF 339

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767910684  1053 AVHYGVAYR--LAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCISWaFATF 1125
Cdd:TIGR03480  340 AIQFSLRYReeRFRGGNHREALSVAARRMGAALLLAALATAAGFFAFLPTDYKGVSELGIIAGTGMFIAL-FVTL 413
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 455-1083 1.48e-09

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 63.00  E-value: 1.48e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684   455 FSPTEKGESMM---NIYLDNFENWNSSDGVTTITgieFGIKHSLfQDYLLMDTVYPAIAIVIVLLVMCVYT--------- 522
Cdd:TIGR00917  522 VNKTNKTEKAVaweKAFIQLAKDELLPMVQATIS---FSAERSI-EDELKRESTADVITIAISYLVMFAYIsltlgdspr 597

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684   523 -KSMFITLMTMFAIISSLIVsyfLYRVVFHFEFFPFMNLTALIILV--------GIGADDAFVLCDVWNYTKF------- 586
Cdd:TIGR00917  598 lKSLYVTSKVLLGLSGILIV---MLSVLGSVGVFSAVGLKSTLIIMevipflvlAVGVDNIFILVFFYFYLEYfyrqvgv 674

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684   587 DKPHAETSE-TVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVL----HER 661
Cdd:TIGR00917  675 DNEQELTLErRLSRALMEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLdfkrTED 754

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684   662 YLLNIFTCFKKPQQQIYDNKSCwTVACQKCHKVLFAISEASRIFFEKVLPCIVIkfrylwlFWFLALTVGGAYIVCINP- 740
Cdd:TIGR00917  755 KRVDCFPCIKTSKSSISAEKGS-GQRKAGLLTRYFKEVYAPVLLHWIVKIVVIA-------FFVGLLMAGIALSTRVEIg 826

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684   741 ---KMKLPSleLSEFQVFRSShpFERYDAEYKKLFMFERVHHGEELHMPITVIWGVSPEDNGNPLNpkskgklTLDSSFN 817
Cdd:TIGR00917  827 ldqQIVLPQ--DSYLQIYFAS--LTPLLEVGPPFYIVIKGDYNYTDFESQNKLCTMGGCDKDSIVN-------VFNNLSY 895

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684   818 IASPASqAWILHF-----------CQKLRNQTFFYQTDEQDFtSCFIET-----------FKQWMENQDCDEPAlyPCCS 875
Cdd:TIGR00917  896 IAKPAS-SWLDDYlvwlspqasccCRKFTNGTFCNGPDPQCF-RCADLSsdaqgrpsttqFKEKLPWFLNALPS--ADCA 971

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684   876 HWSFPYKQEIFELCIKRAIMELERSTGYHLDSKTPgprfdiNDTIRAVvlefQSTYLFTlayekmhqfykevdswissel 955
Cdd:TIGR00917  972 KGGHAAYSSAVDLQGYATIIQASSFRTYHTPLNTQ------VDFINAM----RAAQEFA--------------------- 1020

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684   956 SSAPEGLSNGWFVSNL--EFYDLQDSLSDGTLIAMGLSVAVAFSV-MLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGW 1032
Cdd:TIGR00917 1021 AKVSRSSKMEVYPYSVfyVFFEQYLTIWKTAIINLSIALGAIFIVcLFLLQLNALSVVNLIMSVGMAVVFCVGIMHLWSI 1100

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767910684  1033 ELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRVGSAM 1083
Cdd:TIGR00917 1101 SLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFSRNHRAKEALGGMGSSV 1151
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 452-658 1.22e-08

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 59.85  E-value: 1.22e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684   452 SMLFSPTEKgESMMNIYLDNFENWNSSDGVT-TITG--IEFGIKHSLFQDYLLMDTVYPAIAIVIVLLVmcVY---TKSM 525
Cdd:TIGR00921  519 QVQLKQGEP-KVQGRKILRDVQHEHPPPGVKvGVTGlpVAFAEMHELVNEGMRRMTIAGAILVLMILLA--VFrnpIKAV 595

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684   526 FiTLMTMFAIISSLIVSYFLYRVVFhfeffpFMNLTALI-ILVGIGADDAFVLCDvwnytKFDKPHAETS--ETVSITLQ 602
Cdd:TIGR00921  596 F-PLIAIGSGILWAIGLMGLRGIPS------FLAMATTIsIILGLGMDYSIHLAE-----RYFEERKEHGpkEAITHTME 663

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 767910684   603 HAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVL 658
Cdd:TIGR00921  664 RTGPGILFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLSSLTAALVVFPALLVL 719
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
 975-1111 1.46e-07

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 55.38  E-value: 1.46e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684   975 DLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGwELNVLE----SVTISVAVGLSV 1050
Cdd:pfam03176  135 DLRDAGDRDLGLIEAVTLVVIFIILLIVYRSVVAALLPLLTVGLSLGAAQGLVAILA-HILGIGlstfALNLLVVLLIAV 213

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767910684  1051 --DFAVHYGVAYR--LAPDPDREGKVIFSLSRVGSAMAMAALTtfVAGAMMmpstVLAYTQLGTF 1111
Cdd:pfam03176  214 gtDYALFLVSRYReeLRAGEDREEAVIRAVRGTGKVVTAAGLT--VAIAML----ALSFARLPVF 272
actII TIGR00833
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ...
 508-674 5.50e-07

Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 129913 [Multi-domain]  Cd Length: 910  Bit Score: 54.59  E-value: 5.50e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684   508 AIAIVIVLLVMCVYTKSMFITLMTMFAIISSLIVSYFLYRVVFHFEF-----FPFMNLTALIIlvGIGADDAFVLcdVWN 582
Cdd:TIGR00833  180 ATTGIIVLIILLLVYRSPITMLVPLVSVGFSVVVAQGIVSLLGIPGLigvnaQTTVLLTALVI--GAGTDYAVFL--TGR 255

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684   583 YTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVLHERY 662
Cdd:TIGR00833  256 YHEERRKGESLEEAAAEALRGTGKAILGSALTVAVAFLALSLARLPSFKTLGVSCAVGVLVALLNAVTLTPALLTLEGRE 335

                          170
                   ....*....|..
gi 767910684   663 LLniftcFKKPQ 674
Cdd:TIGR00833  336 GL-----MKPGR 342
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
 972-1110 6.70e-07

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 54.00  E-value: 6.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684  972 EFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLV--------LLGWELNVLESVT-- 1041
Cdd:COG2409   507 VNIDISDALADDLPLVIPVVLGLIFLLLLLLFRSVVAPLKAVLTNLLSLGAALGVLVlvfqhgwlLLGFTPGPLDSFVpl 586

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684 1042 --ISVAVGLSVDfavhYGV--------AYRLAPDPdREGkVIFSLSRVGS-----AMAMAAltTFVAgamMMPSTVLAYT 1106
Cdd:COG2409   587 llFVILFGLGMD----YEVflvsrireEYDRGGGT-REA-VIRGLARTGRvitsaALIMAA--VFAA---FATSPLVFLK 655


                  ....
gi 767910684 1107 QLGT 1110
Cdd:COG2409   656 QIGF 659
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
 508-658 1.16e-05

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 50.00  E-value: 1.16e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684   508 AIAIVIVLLVMCVYTKSMFITLMTMFAIISSLIVSY-FLYRVVFHFeffpfmNL--TALIIL-VGIGADDA--FVLcdvw 581
Cdd:TIGR03480  276 LLSFVLVLVLLWLALRSPRLVFAVLVTLIVGLILTAaFATLAVGHL------NLisVAFAVLfIGLGVDFAiqFSL---- 345

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767910684   582 NYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVL 658
Cdd:TIGR03480  346 RYREERFRGGNHREALSVAARRMGAALLLAALATAAGFFAFLPTDYKGVSELGIIAGTGMFIALFVTLTVLPALLRL 422
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
 508-658 1.21e-05

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 49.21  E-value: 1.21e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684   508 AIAIVIVLLVMCVYTKSMFITLMTMFAIISSLIVSYFLYRVVFHFEFFPfMNLTAL----IILVGIGADDAFVLcdVWNY 583
Cdd:pfam03176  149 AVTLVVIFIILLIVYRSVVAALLPLLTVGLSLGAAQGLVAILAHILGIG-LSTFALnllvVLLIAVGTDYALFL--VSRY 225

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767910684   584 TKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVL 658
Cdd:pfam03176  226 REELRAGEDREEAVIRAVRGTGKVVTAAGLTVAIAMLALSFARLPVFAQVGPTIAIGVLVDVLAALTLLPALLAL 300
COG4258 COG4258
Predicted exporter [General function prediction only];
1043-1127 1.96e-05

Predicted exporter [General function prediction only];


Pssm-ID: 443400 [Multi-domain]  Cd Length: 783  Bit Score: 49.47  E-value: 1.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684 1043 SVAVGLSVDFAVHYGVAYRLAPDPDREgkviFSLSRVGSAMAMAALTTFVAGAMMM--PSTVLAytQLGTFMMLIMCISW 1120
Cdd:COG4258   310 SSLIGVAVDYSLHYLTHRRAAGEWDPR----AALRRIWPTLLLGLLTTVLGYLALLfsPFPGLR--QLGVFAAAGLLAAA 383


                  ....*..
gi 767910684 1121 AFATFFF 1127
Cdd:COG4258   384 LTTLLWL 390
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 973-1125 2.33e-05

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 49.07  E-value: 2.33e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684   973 FYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDF 1052
Cdd:TIGR00921  558 FAEMHELVNEGMRRMTIAGAILVLMILLAVFRNPIKAVFPLIAIGSGILWAIGLMGLRGIPSFLAMATTISIILGLGMDY 637

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767910684  1053 AVHygVAYRLAPDPDREGKV---IFSLSRVGSAMAMAALTTFVAGAMMMPSTVLAYTQLGtFMMLIMCISWAFATF 1125
Cdd:TIGR00921  638 SIH--LAERYFEERKEHGPKeaiTHTMERTGPGILFSGLTTAGGFLSLLLSHFPIMRNFG-LVQGIGVLSSLTAAL 710
2A060602 TIGR00918
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
556-673 4.22e-05

The Eukaryotic (Putative) Sterol Transporter (EST) Family;


Pssm-ID: 273338 [Multi-domain]  Cd Length: 1145  Bit Score: 48.34  E-value: 4.22e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684   556 PFMNLtaliilvGIGADDAFVLCDVWNYTKFDKPHAETSETVsitLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGV 635
Cdd:TIGR00918  464 PFLAL-------GVGVDDVFLLAHAFSETGQNIPFEERTGEC---LKRTGASVVLTSISNVTAFFMAALIPIPALRAFSL 533

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 767910684   636 YAGTAILVNYVLMVTWLPAVVVL----HERYLLNIFTCFKKP 673
Cdd:TIGR00918  534 QAAIVVVFNFAAVLLVFPAILSLdlrrREDRRLDIFCCFFSP 575
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 508-660 7.40e-05

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 47.52  E-value: 7.40e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684   508 AIAIVIVLLVMCVYTKSMFITLMTMFAIISSlivsyflyrVVFHFEFFPFM-------NLTALIILVGIGAD-DAFVLcd 579
Cdd:TIGR00921  200 AISGILVVLVLLLDFKRWWRPLLPLVIILFG---------VAWVLGIMGWLgiplyatTLLAVPMLIGVGIDyGIQTL-- 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684   580 vwnyTKFDKPHAE---TSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVV 656
Cdd:TIGR00921  269 ----NRYEEERDIgraKGEAIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALL 344


                   ....
gi 767910684   657 VLHE 660
Cdd:TIGR00921  345 QSID 348
COG4258 COG4258
Predicted exporter [General function prediction only];
988-1090 6.57e-04

Predicted exporter [General function prediction only];


Pssm-ID: 443400 [Multi-domain]  Cd Length: 783  Bit Score: 44.46  E-value: 6.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684  988 MGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFAVHygvayrLAPDPD 1067
Cdd:COG4258   645 LLLALLLILLLLLLRLRSLRRALRVLLPPLLAVLLTLAILGLLGIPLNLFHLIALLLVLGIGIDYALF------FTEGLL 718

                          90       100
                  ....*....|....*....|...
gi 767910684 1068 REGkvifSLSRVGSAMAMAALTT 1090
Cdd:COG4258   719 DKG----ELARTLLSILLAALTT 737
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 974-1117 7.91e-04

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 44.06  E-value: 7.91e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684   974 YDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFA 1053
Cdd:TIGR00921  185 YDIEREFGKDMGTTMAISGILVVLVLLLDFKRWWRPLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVPMLIGVGIDYG 264

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767910684  1054 VHYGVAYRlapDPDREGK-----VIFSLSRVGSAMAMAALTTfVAGAMMMPSTVLAYTQ---LGTFMMLIMC 1117
Cdd:TIGR00921  265 IQTLNRYE---EERDIGRakgeaIVTAVRRTGRAVLIALLTT-SAGFAALALSEFPMVSefgLGLVAGLITA 332
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
 973-1111 8.70e-04

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 43.99  E-value: 8.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684  973 FYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVlESVTISVAV----GL 1048
Cdd:COG2409   160 AADLNEAFEEDLGRAELITLPVALVVLLLVFRSLVAALLPLLTAGLAVGVALGLLALLAAFTDV-SSFAPNLLTmlglGV 238

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767910684 1049 SVDFAVHYgVA-YR--LAPDPDREGKVIFSLSRVGSAMAMAALTtfVAGAMMmpstVLAYTQLGTF 1111
Cdd:COG2409   239 GIDYALFL-VSrYReeLRAGEDREEAVARAVATAGRAVLFSGLT--VAIALL----GLLLAGLPFL 297
MATE_like_8 cd13134
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 985-1124 2.90e-03

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240539 [Multi-domain]  Cd Length: 438  Bit Score: 42.10  E-value: 2.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684  985 LIAMGLSVAVAFSVMLLTTWNIIISLYA-IISIAGTifvtvgSLVLLGWE-LNVLE------SVTISVAVGLSVDFAVHY 1056
Cdd:cd13134   134 LQALSLTLSAILRSHGRTKIPMYVSLIMnILNIVGN------YLLIFGWFgLPKLGvagvaiSTVISRAVGLVLLFILLF 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684 1057 ---GVAYRLAPDPDREGKVIFSLSRVG--SA-------MAMAALTTFVAgamMMPSTVLA-YTQLGTFMMLIMCISWAFA 1123
Cdd:cd13134   208 rklKIRFRLKDLRPFPKKLLKKILKIGlpSAgeelsynLSQTVITAFIA---RLGTAALAaRTYASNISMFVFLFSLAIG 284


                  .
gi 767910684 1124 T 1124
Cdd:cd13134   285 Q 285
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
 994-1128 4.00e-03

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 41.91  E-value: 4.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684   994 VAFSVMLLTTW-NIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDregkv 1072
Cdd:TIGR03480  723 VAITVLLLLTLrRVRDVLLVLAPLLLAGLLTVAAMVLLGIPFNFANIIALPLLLGLGVDFGIYMVHRWRNGVDSG----- 797

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767910684  1073 ifslSRVGSAMAMA----ALTTFVA-GAMMMPStvlaytQLGTFMM-LIMCISWAF---ATFFFQ 1128
Cdd:TIGR03480  798 ----NLLQSSTARAvffsALTTATAfGSLAVSS------HPGTASMgILLSLGLGLtllCTLIFL 852
2A060602 TIGR00918
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
985-1100 9.25e-03

The Eukaryotic (Putative) Sterol Transporter (EST) Family;


Pssm-ID: 273338 [Multi-domain]  Cd Length: 1145  Bit Score: 40.64  E-value: 9.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910684   985 LIAMGLSVAVAF---SVMLLTTWNIIISLYAIISIAGTIFvtvGSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYr 1061
Cdd:TIGR00918  968 LLSISVVLACTFlvcALLLLNPWTAGLIVLVLALMTVELF---GMMGLLGIKLSAIPVVILIASVGIGVEFTVHIALGF- 1043

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 767910684  1062 LAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPS 1100
Cdd:TIGR00918 1044 LTAIGDRNRRAVLALEHMFAPVLDGALSTLLGVLMLAGS 1082
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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