Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910567  23 PIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHRylGKEILRETPD-NILE--VQESGEYRCQAQGSPLSSPVHLD 99
Cdd:cd05752    1 AVVSLDPPWTTVFQGEKVTLTCQGFYSPEQNSTQWYHN--GTLISSTSSSyRIVAatVNDSGEYRCQTQGSSLSDPVHLE 78

                 .
gi 767910567 100 F 100
Cdd:cd05752   79 V 79

Immunoglobulin domain; This family contains immunoglobulin-like domains.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767910567  473 PVLTLSSAEALTFEGATVTLHCEVQrGSPQILYQFYHEDMPLWSSSTPSVGRVSFSFSL-----TEGHSGNYYCTADN 545
Cdd:pfam13927   2 PVITVSPSSVTVREGETVTLTCEAT-GSPPPTITWYKNGEPISSGSTRSRSLSGSNSTLtisnvTRSDAGTYTCVASN 78

Immunoglobulin domain; This domain contains immunoglobulin-like domains.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910567  380 PVLNLSSPEdlIFEGAKVTLHCEAQrGSLPILYQFHHEGAALerrsanSAGGVAISFSLTAEHSGNYYCTADNGFGPQRS 459
Cdd:pfam13895   2 PVLTPSPTV--VTEGEPVTLTCSAP-GNPPPSYTWYKDGSAI------SSSPNFFTLSVSAEDSGTYTCVARNGRGGKVS 72

                  ....*..
gi 767910567  460 KAVSLSV 466
Cdd:pfam13895  73 NPVELTV 79

Immunoglobulin domain; This domain contains immunoglobulin-like domains.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910567  287 PVLTLSPEKAlnFEGTKVTLHCETQEDSLrTLYRFYHEGVPLRhksvrcERGASISFSLTTENSGNYYCTADNGLGAKPS 366
Cdd:pfam13895   2 PVLTPSPTVV--TEGEPVTLTCSAPGNPP-PSYTWYKDGSAIS------SSPNFFTLSVSAEDSGTYTCVARNGRGGKVS 72

                  ....*..
gi 767910567  367 KAVSLSV 373
Cdd:pfam13895  73 NPVELTV 79

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767910567 191 RPVLRASSFQPIS-GNPVTLTC----ETQL-SLERSDVPLRFRffrddQTLGLGWSLSPNFQITAMWSKDSGFYWC 260
Cdd:cd16843    1 KPFLSAEPSSVVPlGENVTIRCqgppEAVLfQLYKEGNSLSQG-----TVREKEPQNKAEFYIPHMDRNHAGRYRC 71

First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910567  23 PIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHRylGKEILRETPD-NILE--VQESGEYRCQAQGSPLSSPVHLD 99
Cdd:cd05752    1 AVVSLDPPWTTVFQGEKVTLTCQGFYSPEQNSTQWYHN--GTLISSTSSSyRIVAatVNDSGEYRCQTQGSSLSDPVHLE 78

                 .
gi 767910567 100 F 100
Cdd:cd05752   79 V 79

Immunoglobulin domain; This family contains immunoglobulin-like domains.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767910567  473 PVLTLSSAEALTFEGATVTLHCEVQrGSPQILYQFYHEDMPLWSSSTPSVGRVSFSFSL-----TEGHSGNYYCTADN 545
Cdd:pfam13927   2 PVITVSPSSVTVREGETVTLTCEAT-GSPPPTITWYKNGEPISSGSTRSRSLSGSNSTLtisnvTRSDAGTYTCVASN 78

Immunoglobulin domain; This domain contains immunoglobulin-like domains.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910567  380 PVLNLSSPEdlIFEGAKVTLHCEAQrGSLPILYQFHHEGAALerrsanSAGGVAISFSLTAEHSGNYYCTADNGFGPQRS 459
Cdd:pfam13895   2 PVLTPSPTV--VTEGEPVTLTCSAP-GNPPPSYTWYKDGSAI------SSSPNFFTLSVSAEDSGTYTCVARNGRGGKVS 72

                  ....*..
gi 767910567  460 KAVSLSV 466
Cdd:pfam13895  73 NPVELTV 79

Immunoglobulin domain; This domain contains immunoglobulin-like domains.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910567  287 PVLTLSPEKAlnFEGTKVTLHCETQEDSLrTLYRFYHEGVPLRhksvrcERGASISFSLTTENSGNYYCTADNGLGAKPS 366
Cdd:pfam13895   2 PVLTPSPTVV--TEGEPVTLTCSAPGNPP-PSYTWYKDGSAIS------SSPNFFTLSVSAEDSGTYTCVARNGRGGKVS 72

                  ....*..
gi 767910567  367 KAVSLSV 373
Cdd:pfam13895  73 NPVELTV 79

Immunoglobulin domain; This domain contains immunoglobulin-like domains.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910567  105 LILQAPLS-VFEGDSVVLRCRAKAEVTLNNTIYKNDNVlafLNKRTDFHIPHACLKDNGAYRCT-GYKESCCPvsSNTVK 182
Cdd:pfam13895   2 PVLTPSPTvVTEGEPVTLTCSAPGNPPPSYTWYKDGSA---ISSSPNFFTLSVSAEDSGTYTCVaRNGRGGKV--SNPVE 76

                  ...
gi 767910567  183 IQV 185
Cdd:pfam13895  77 LTV 79

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767910567 583 LELHCEAPRGSPPILYWfYHEDVTLGSSSAPSGGEASFNLSLT-----AEHSGNYSCEANNGLVAQHSDTI 648
Cdd:cd00096    1 VTLTCSASGNPPPTITW-YKNGKPLPPSSRDSRRSELGNGTLTisnvtLEDSGTYTCVASNSAGGSASASV 70

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910567   486 EGATVTLHCEVQrGSPQILYQFYHEDM-PLWSSSTPSVGRVSFSFSLT-----EGHSGNYYCTADNGFGPQRSEVvslFV 559
Cdd:smart00410   8 EGESVTLSCEAS-GSPPPEVTWYKQGGkLLAESGRFSVSRSGSTSTLTisnvtPEDSGTYTCAATNSSGSASSGT---TL 83

                   ..
gi 767910567   560 TV 561
Cdd:smart00410  84 TV 85

Immunoglobulin domain; This domain contains immunoglobulin-like domains.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767910567   27 LQPPWTTVFQGERVTLTCKGfrfYSPQKTKwYHRYLGKEILRETPD---NILEVQESGEYRCQA---QGSPLSSPVHL 98
Cdd:pfam13895   4 LTPSPTVVTEGEPVTLTCSA---PGNPPPS-YTWYKDGSAISSSPNfftLSVSAEDSGTYTCVArngRGGKVSNPVEL 77

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910567   670 AVVGDLLELHCEALRGSSPILYWFYHEDVTL---GKISA-PSGGGASFNLS-LTTEHSGIYSCEADNGLEAQRSEmVTLK 744
Cdd:smart00410   6 VKEGESVTLSCEASGSPPPEVTWYKQGGKLLaesGRFSVsRSGSTSTLTISnVTPEDSGTYTCAATNSSGSASSG-TTLT 84

                   .
gi 767910567   745 V 745
Cdd:smart00410  85 V 85

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910567    29 PPWTTVFQGERVTLTCKGFRFYSPQKTkWYHRYL------GKEILRETPDN----ILEVQE--SGEYRCQAqgsplSSPV 96
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPPEVT-WYKQGGkllaesGRFSVSRSGSTstltISNVTPedSGTYTCAA-----TNSS 74

                           90
                   ....*....|
gi 767910567    97 HLDFSSASLI 106
Cdd:smart00410  75 GSASSGTTLT 84

Second Ig-like domain of Junctional adhesion molecule-1 (JAM1); a member of the I-set of IgSF domains; The members here are composed of the second Ig-like domain of Junctional adhesion molecule-1 (JAM1). JAM1 is an immunoglobulin superfamily (IgSF) protein with two Ig-like domains in its extracellular region; it plays a role in the formation of endothelial and epithelial tight junction and acts as a receptor for mammalian reovirus sigma-1. The IgSF is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. The two sheets are linked together by a conserved disulfide bond between B strand and F strand. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The second Ig-like domain of JAM1 is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, the A strand of the I-set is discontinuous but lacks a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910567 301 GTKVTLHCETQEDSLRTLYRFYHEGVPL--RHKSVRCERGASISFSLTT----------ENSGNYYCTADNGLG-AKPSK 367
Cdd:cd20950   12 GNRAVLTCSEPDGSPPSEYTWFKDGVVMptNPKSTRAFSNSSYSLDPTTgelvfdplsaSDTGEYSCEARNGYGtPMRSN 91

                 ....*.
gi 767910567 368 AVSLSV 373
Cdd:cd20950   92 AVRMEA 97

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767910567 676 LELHCEALRGSSPILYWfYHEDVTLGKISAPSGGGASFNLSLT-----TEHSGIYSCEADNGLEAQRSEMV 741
Cdd:cd00096    1 VTLTCSASGNPPPTITW-YKNGKPLPPSSRDSRRSELGNGTLTisnvtLEDSGTYTCVASNSAGGSASASV 70

Immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors, Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains; The members here are composed of the first and second immunoglobulin (Ig)-like domains found in Leukocyte Ig-like receptors (LILRs), Natural killer inhibitory receptors (KIRs, also known as also known as cluster of differentiation (CD) 158), and similar proteins. This group includes LILRB1 (also known as LIR-1), LILRA5 (also known as LIR9), an activating natural cytotoxicity receptor NKp46, the immune-type receptor glycoprotein VI (GPVI), and the IgA-specific receptor Fc-alphaRI (also known as cluster of differentiation (CD) 89). LILRs are a family of immunoreceptors expressed on expressed on T and B cells, on monocytes, dendritic cells, and subgroups of natural killer (NK) cells. The human LILR family contains nine proteins (LILRA1-3, and 5, and LILRB1-5). From functional assays, and as the cytoplasmic domains of various LILRs, for example LILRB1, LILRB2 (also known as LIR-2), and LILRB3 (also known as LIR-3) contain immunoreceptor tyrosine-based inhibitory motifs (ITIMs), it is thought that LIR proteins are inhibitory receptors. Of the eight LIR family proteins, only LILRB1, and LILRB2, show detectable binding to class I MHC molecules; ligands for the other members have yet to be determined. The extracellular portions of the different LIR proteins contain different numbers of Ig-like domains for example, four in the case of LILRB1, and LILRB2, and two in the case of LILRB4 (also known as LIR-5). The activating natural cytotoxicity receptor NKp46 is expressed in natural killer cells, and is organized as an extracellular portion having two Ig-like extracellular domains, a transmembrane domain, and a small cytoplasmic portion. GPVI, which also contains two Ig-like domains, participates in the processes of collagen-mediated platelet activation and arterial thrombus formation. Fc-alphaRI is expressed on monocytes, eosinophils, neutrophils, and macrophages; it mediates IgA-induced immune effector responses such as phagocytosis, antibody-dependent cell-mediated cytotoxicity and respiratory burst. Killer cell immunoglobulin-like receptors (KIRs; also known as CD158 for human KIR) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. KIRs are a family of highly polymorphic activating and inhibitory receptors that serve as key regulators of human NK cell function. The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The major ligands for KIR are MHC class I (HLA-A, -B or -C) molecules.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767910567 191 RPVLRASSFQPIS-GNPVTLTC----ETQL-SLERSDVPLRFRffrddQTLGLGWSLSPNFQITAMWSKDSGFYWC 260
Cdd:cd16843    1 KPFLSAEPSSVVPlGENVTIRCqgppEAVLfQLYKEGNSLSQG-----TVREKEPQNKAEFYIPHMDRNHAGRYRC 71

First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910567  23 PIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHRylGKEILRETPD-NILE--VQESGEYRCQAQGSPLSSPVHLD 99
Cdd:cd05752    1 AVVSLDPPWTTVFQGEKVTLTCQGFYSPEQNSTQWYHN--GTLISSTSSSyRIVAatVNDSGEYRCQTQGSSLSDPVHLE 78

                 .
gi 767910567 100 F 100
Cdd:cd05752   79 V 79

Immunoglobulin domain; This family contains immunoglobulin-like domains.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767910567  473 PVLTLSSAEALTFEGATVTLHCEVQrGSPQILYQFYHEDMPLWSSSTPSVGRVSFSFSL-----TEGHSGNYYCTADN 545
Cdd:pfam13927   2 PVITVSPSSVTVREGETVTLTCEAT-GSPPPTITWYKNGEPISSGSTRSRSLSGSNSTLtisnvTRSDAGTYTCVASN 78

Immunoglobulin domain; This family contains immunoglobulin-like domains.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767910567  565 RPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWfYHEDVTLGSSSAPSGGEASFNLSL-----TAEHSGNYSCEANN 638
Cdd:pfam13927   1 KPVITVSPSSVTVREGETVTLTCEATGSPPPTITW-YKNGEPISSGSTRSRSLSGSNSTLtisnvTRSDAGTYTCVASN 78

Immunoglobulin domain; This domain contains immunoglobulin-like domains.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910567  754 LTLRAPGTHAAVGDLLELHCEALrGSPLILYRFFHEDVTLgnrssPSGGASLNLSLTAEHSGNYSCEADNGLGAQRSETV 833
Cdd:pfam13895   2 PVLTPSPTVVTEGEPVTLTCSAP-GNPPPSYTWYKDGSAI-----SSSPNFFTLSVSAEDSGTYTCVARNGRGGKVSNPV 75

                  ..
gi 767910567  834 TL 835
Cdd:pfam13895  76 EL 77

Immunoglobulin domain; This family contains immunoglobulin-like domains.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767910567  751 RPVLTLRAPGTHAAVGDLLELHCEAlRGSPLILYRFFHEDVTLGNRSSP-----SGGASLNL-SLTAEHSGNYSCEADN 823
Cdd:pfam13927   1 KPVITVSPSSVTVREGETVTLTCEA-TGSPPPTITWYKNGEPISSGSTRsrslsGSNSTLTIsNVTRSDAGTYTCVASN 78

Immunoglobulin domain; This domain contains immunoglobulin-like domains.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910567  568 LTLRVPRAQAVVGDLLELHCEAPrGSPPILYWFYHEDVTLGSSSApsggeaSFNLSLTAEHSGNYSCEANNGLVAQHSDT 647
Cdd:pfam13895   2 PVLTPSPTVVTEGEPVTLTCSAP-GNPPPSYTWYKDGSAISSSPN------FFTLSVSAEDSGTYTCVARNGRGGKVSNP 74

                  ....*
gi 767910567  648 ISLSV 652
Cdd:pfam13895  75 VELTV 79

Immunoglobulin domain; This family contains immunoglobulin-like domains.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767910567  658 RPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWfYHEDVTLGKISAPSGGGASFNLSL-----TTEHSGIYSCEADN 731
Cdd:pfam13927   1 KPVITVSPSSVTVREGETVTLTCEATGSPPPTITW-YKNGEPISSGSTRSRSLSGSNSTLtisnvTRSDAGTYTCVASN 78

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910567   577 AVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSS----APSGGEASFNLS-LTAEHSGNYSCEANNGLVaQHSDTISLS 651
Cdd:smart00410   6 VKEGESVTLSCEASGSPPPEVTWYKQGGKLLAESGrfsvSRSGSTSTLTISnVTPEDSGTYTCAATNSSG-SASSGTTLT 84

                   .
gi 767910567   652 V 652
Cdd:smart00410  85 V 85

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767910567 490 VTLHCEVqRGSPQILYQFYHEDMPLWSSSTPSVGRVSFSFSLT-----EGHSGNYYCTADNGFGPQRSEVV 555
Cdd:cd00096    1 VTLTCSA-SGNPPPTITWYKNGKPLPPSSRDSRRSELGNGTLTisnvtLEDSGTYTCVASNSAGGSASASV 70

First immunoglobulin (Ig) domain of contactin; member of the I-set of (Ig) superfamily domains; The members here are composed of the first immunoglobulin (Ig) domain of contactins. Contactins are neural cell adhesion molecules and are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains anchored to the membrane by glycosylphosphatidylinositol. The first four Ig domains form the intermolecular binding fragment, which arranges as a compact U-shaped module via contacts between Ig domains 1 and 4, and between Ig domains 2 and 3. Contactin-2 (TAG-1, axonin-1) may play a part in the neuronal processes of neurite outgrowth, axon guidance and fasciculation, and neuronal migration. This group also includes contactin-1 and contactin-5. The different contactins show different expression patterns in the central nervous system. During development and in adulthood, contactin-2 is transiently expressed in subsets of central and peripheral neurons. Contactin-5 is expressed specifically in the rat postnatal nervous system, peaking at about 3 weeks postnatal, and a lack of contactin-5 (NB-2) results in an impairment of neuronal activity in the rat auditory system. Contactin-5 is highly expressed in the adult human brain in the occipital lobe and in the amygdala. Contactin-1 is differentially expressed in tumor tissues and may, through a RhoA mechanism, facilitate invasion and metastasis of human lung adenocarcinoma. This group belongs to the I-set of IgSF domains.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910567 387 PEDLIF-EGA---KVTLHCEAqRGSLPILYQFHHEGAALE----RRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQR 458
Cdd:cd04967    8 PDDTIFpEDSdekKVALNCRA-RANPVPSYRWLMNGTEIDlesdYRYSLVDGTLVISNPSKAKDAGHYQCLATNTVGSVL 86

                 ....*..
gi 767910567 459 SKAVSLS 465
Cdd:cd04967   87 SREATLQ 93

Immunoglobulin domain; This domain contains immunoglobulin-like domains.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767910567   27 LQPPWTTVFQGERVTLTCKGfrfYSPQKTKwYHRYLGKEILRETPD---NILEVQESGEYRCQA---QGSPLSSPVHL 98
Cdd:pfam13895   4 LTPSPTVVTEGEPVTLTCSA---PGNPPPS-YTWYKDGSAISSSPNfftLSVSAEDSGTYTCVArngRGGKVSNPVEL 77

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910567   670 AVVGDLLELHCEALRGSSPILYWFYHEDVTL---GKISA-PSGGGASFNLS-LTTEHSGIYSCEADNGLEAQRSEmVTLK 744
Cdd:smart00410   6 VKEGESVTLSCEASGSPPPEVTWYKQGGKLLaesGRFSVsRSGSTSTLTISnVTPEDSGTYTCAATNSSGSASSG-TTLT 84

                   .
gi 767910567   745 V 745
Cdd:smart00410  85 V 85

Immunoglobulin domain; This domain contains immunoglobulin-like domains.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910567  658 RPILtfRAPRAQAVVGDLLELHCEALrGSSPILYWFYHEDVTLgkisapSGGGASFNLSLTTEHSGIYSCEADNGLEAQR 737
Cdd:pfam13895   1 KPVL--TPSPTVVTEGEPVTLTCSAP-GNPPPSYTWYKDGSAI------SSSPNFFTLSVSAEDSGTYTCVARNGRGGKV 71

                  ....*...
gi 767910567  738 SEMVTLKV 745
Cdd:pfam13895  72 SNPVELTV 79

Second Ig-like domain of Junctional adhesion molecule-1 (JAM1); a member of the I-set of IgSF domains; The members here are composed of the second Ig-like domain of Junctional adhesion molecule-1 (JAM1). JAM1 is an immunoglobulin superfamily (IgSF) protein with two Ig-like domains in its extracellular region; it plays a role in the formation of endothelial and epithelial tight junction and acts as a receptor for mammalian reovirus sigma-1. The IgSF is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. The two sheets are linked together by a conserved disulfide bond between B strand and F strand. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The second Ig-like domain of JAM1 is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, the A strand of the I-set is discontinuous but lacks a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910567 473 PVLTLSSAEALtfeGATVTLHCEVQRGSPQILYQFYHEDMPL---------WSSST----PSVGRVSFSfSLTEGHSGNY 539
Cdd:cd20950    1 PTVNIPSSATI---GNRAVLTCSEPDGSPPSEYTWFKDGVVMptnpkstraFSNSSysldPTTGELVFD-PLSASDTGEY 76

                         90
                 ....*....|....*....
gi 767910567 540 YCTADNGFG-PQRSEVVSL 557
Cdd:cd20950   77 SCEARNGYGtPMRSNAVRM 95

Third immunoglobulin domain in Cluster of Differentiation (CD) 22; member of the Constant 2 (C2)-set of IgSF domains; The members here are composed of the third immunoglobulin domain in Cluster of Differentiation (CD) 22 (also known as Siglec-2). CD22, a sialic-acid binding immunoglobulin type-lectin (Siglec) family member, is an inhibitory co-receptor of the B-cell receptor (BCR). The inhibitory function of CD22 and its restricted expression on B cells makes CD22 an attractive target against dysregulated B cells that cause autoimmune diseases and B-cell-derived cancers. CD22 plays a vital role in establishing a baseline level of B-cell inhibition, and thus is an important determinant of homeostasis in humoral immunity. Siglecs are primarily expressed on immune cells and recognize sialic acid-containing glycan ligands. Siglecs are organized as an extracellular module composed of Ig-like domains (an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains), followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG (Siglec-4, myelin-associated glycoprotein), the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the C2-set of IgSF domains, having A, B, and E strands in one beta-sheet and A', G, F, C' in the other. Unlike other Ig domain sets, the C2-set lacks the D strand.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910567 475 LTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDmplwSSSTPSVGRVSFSFS-LTEGHSGNYYCTADNGFGPQRSE 553
Cdd:cd20937    5 IKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKD----GTSLKKQNTFTLNLReVTKDQSGKYCCQVSNDVGPGRSE 80

                 ....*.
gi 767910567 554 VVSLFV 559
Cdd:cd20937   81 EVFLQV 86