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Conserved domains on  [gi|767910044|ref|XP_011508131|]
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SLAM family member 7 isoform X2 [Homo sapiens]

Protein Classification

Ig_SLAM-CD84_like_N domain-containing protein( domain architecture ID 11617245)

Ig_SLAM-CD84_like_N domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 27-125 6.56e-30

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


:

Pssm-ID: 409517  Cd Length: 102  Bit Score: 109.33  E-value: 6.56e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910044  27 KELVGSVGGAVTFPLK-SKVKQVDSIVWTFNTTPLVtIQPEGGT---IIVTQNRNRERVDFPDGGYSLKLSKLKKNDSGI 102
Cdd:cd16842    1 KEVNGILGGSVTFPLNiSDGQEIENITWSFKTSLAV-IAPGEGGapeIIITDKSYKERLNISQNDYSLQISNLTMEDAGS 79

                         90       100
                 ....*....|....*....|...
gi 767910044 103 YYVGIYSSSLQQPSTQEYVLHVY 125
Cdd:cd16842   80 YRARINTKNSRVTITKEFTLHIY 102
 
Name Accession Description Interval E-value
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 27-125 6.56e-30

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409517  Cd Length: 102  Bit Score: 109.33  E-value: 6.56e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910044  27 KELVGSVGGAVTFPLK-SKVKQVDSIVWTFNTTPLVtIQPEGGT---IIVTQNRNRERVDFPDGGYSLKLSKLKKNDSGI 102
Cdd:cd16842    1 KEVNGILGGSVTFPLNiSDGQEIENITWSFKTSLAV-IAPGEGGapeIIITDKSYKERLNISQNDYSLQISNLTMEDAGS 79

                         90       100
                 ....*....|....*....|...
gi 767910044 103 YYVGIYSSSLQQPSTQEYVLHVY 125
Cdd:cd16842   80 YRARINTKNSRVTITKEFTLHIY 102
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 27-122 2.90e-05

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 42.45  E-value: 2.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910044   27 KELVGSVGGAVTFP---LKSKVKQVDSIVWTF-----NTTPLVTIQPEGGTIIVTQNRNRERVDFPDGGYSLKLSKLKKN 98
Cdd:pfam07686   4 REVTVALGGSVTLPctySSSMSEASTSVYWYRqppgkGPTFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNLTLS 83

                          90       100
                  ....*....|....*....|....*.
gi 767910044   99 DSGIYYVGIYSSSLQ--QPSTQEYVL 122
Cdd:pfam07686  84 DSGTYTCAVIPSGEGvfGKGTRLTVL 109
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 27-104 1.08e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 37.48  E-value: 1.08e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767910044    27 KELVGSVGGAVTFPLKSKVKQVDSIVWTFNTTPLVTIQPeggtiivtqnrnRERVDFPDGGYSLKLSKLKKNDSGIYY 104
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGSPPPEVTWYKQGGKLLAESG------------RFSVSRSGSTSTLTISNVTPEDSGTYT 67
 
Name Accession Description Interval E-value
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 27-125 6.56e-30

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409517  Cd Length: 102  Bit Score: 109.33  E-value: 6.56e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910044  27 KELVGSVGGAVTFPLK-SKVKQVDSIVWTFNTTPLVtIQPEGGT---IIVTQNRNRERVDFPDGGYSLKLSKLKKNDSGI 102
Cdd:cd16842    1 KEVNGILGGSVTFPLNiSDGQEIENITWSFKTSLAV-IAPGEGGapeIIITDKSYKERLNISQNDYSLQISNLTMEDAGS 79

                         90       100
                 ....*....|....*....|...
gi 767910044 103 YYVGIYSSSLQQPSTQEYVLHVY 125
Cdd:cd16842   80 YRARINTKNSRVTITKEFTLHIY 102
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
 27-111 7.47e-13

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


Pssm-ID: 409431  Cd Length: 98  Bit Score: 63.52  E-value: 7.47e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910044  27 KELVGSVGGAVTFPLKSKVKQVDSIVWTFNTTPLVTIQPEGGTIIVTQNRNRERVDFPDGgySLKLSKLKKNDSGIYYVG 106
Cdd:cd05775    3 GEVYGALGGNVTLTISSLQDDIDEIKWKKTKDKIVEWENNIGPTYFGSFKDRVLLDKESG--SLTIKNLTKEDSGTYELE 80


                 ....*
gi 767910044 107 IYSSS 111
Cdd:cd05775   81 ITSTN 85
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 27-122 2.90e-05

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 42.45  E-value: 2.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910044   27 KELVGSVGGAVTFP---LKSKVKQVDSIVWTF-----NTTPLVTIQPEGGTIIVTQNRNRERVDFPDGGYSLKLSKLKKN 98
Cdd:pfam07686   4 REVTVALGGSVTLPctySSSMSEASTSVYWYRqppgkGPTFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNLTLS 83

                          90       100
                  ....*....|....*....|....*.
gi 767910044   99 DSGIYYVGIYSSSLQ--QPSTQEYVL 122
Cdd:pfam07686  84 DSGTYTCAVIPSGEGvfGKGTRLTVL 109
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 27-104 1.08e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 37.48  E-value: 1.08e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767910044    27 KELVGSVGGAVTFPLKSKVKQVDSIVWTFNTTPLVTIQPeggtiivtqnrnRERVDFPDGGYSLKLSKLKKNDSGIYY 104
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGSPPPEVTWYKQGGKLLAESG------------RFSVSRSGSTSTLTISNVTPEDSGTYT 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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