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Conserved domains on  [gi|767901891|ref|XP_011538798|]
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choline/ethanolaminephosphotransferase 1 isoform X1 [Homo sapiens]

Protein Classification

CDP-alcohol phosphatidyltransferase class-I family protein( domain architecture ID 2159)

CDP-alcohol phosphatidyltransferase class-I family protein such as CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase that catalyzes the committed step in the synthesis of acidic phospholipids

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
PRK10832 super family cl00453
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase;
43-407 4.88e-42

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase;


The actual alignment was detected with superfamily member PLN02359:

Pssm-ID: 469774  Cd Length: 389  Bit Score: 152.24  E-value: 4.88e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901891  43 LSRHQLKRLEEHRYQSAGRSLLEP-LMQGYWEWLVRRVPSWIAPNLITIIGLSINICTTILLVFYCPTATEQAPLWAYIA 121
Cdd:PLN02359   4 IGAHGVAALHRYKYSGVDHSYVAKyVLQPFWSRFVNFFPLWMPPNMITLMGFMFLLTSALLGYIYSPHLDTPPPRWVHFA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901891 122 CACGLFIYQSLDAIDGKQARRTNSSSPLGELFDHGCDSLSTVFVVLGTCIAVQLGTnpdWMFFCCFAGTFMFYCAHWQTY 201
Cdd:PLN02359  84 HGLLLFLYQTFDAVDGKQARRTNSSSPLGELFDHGCDALACAFETMAFGSTAMCGR---DTFWFWVISAVPFYGATWEHF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901891 202 VSGTLRFGIFD-VTESQIIIIICQLLTGTLGPWFW----NFTIPVLN---------------IQMKIFPALCTVAgtiFS 261
Cdd:PLN02359 161 FTNTLILPVINgPTEGLMLIYCAHFFTAIVGAEWWaqdfGKSIPFLSwvpfvseiqtyrivlFLMIAFAVIPTVA---FN 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901891 262 CTNYFRVIftggVGKNGSTIAGTSVLSPF-LHIGSVITLAAMiykkSAVQLFEKHPCLYILTFGFVSAKITNKLVVAHM- 339
Cdd:PLN02359 238 VSNVYKVV----QARKGSMLLALAMLYPFvTLLGGVLIWDYL----SPSDLMRNYPHLVVLGTGLAFGFLVGRMILAHLc 309
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767901891 340 -------TKSEMHLHDTAF-IGPALLFLDQYFNSFIDEYIVLWIALVFSFFDLIRYCVSVCNQIASHLHIHVFRIK 407
Cdd:PLN02359 310 depkglkTNMCMSLLYLPFaIANALTARLNDGVPLVDEFWVLLGYCAFTVSLYLHFATSVIHEITTALGIYCFRIT 385
 
Name Accession Description Interval E-value
PLN02359 PLN02359
ethanolaminephosphotransferase
43-407 4.88e-42

ethanolaminephosphotransferase


Pssm-ID: 166000  Cd Length: 389  Bit Score: 152.24  E-value: 4.88e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901891  43 LSRHQLKRLEEHRYQSAGRSLLEP-LMQGYWEWLVRRVPSWIAPNLITIIGLSINICTTILLVFYCPTATEQAPLWAYIA 121
Cdd:PLN02359   4 IGAHGVAALHRYKYSGVDHSYVAKyVLQPFWSRFVNFFPLWMPPNMITLMGFMFLLTSALLGYIYSPHLDTPPPRWVHFA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901891 122 CACGLFIYQSLDAIDGKQARRTNSSSPLGELFDHGCDSLSTVFVVLGTCIAVQLGTnpdWMFFCCFAGTFMFYCAHWQTY 201
Cdd:PLN02359  84 HGLLLFLYQTFDAVDGKQARRTNSSSPLGELFDHGCDALACAFETMAFGSTAMCGR---DTFWFWVISAVPFYGATWEHF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901891 202 VSGTLRFGIFD-VTESQIIIIICQLLTGTLGPWFW----NFTIPVLN---------------IQMKIFPALCTVAgtiFS 261
Cdd:PLN02359 161 FTNTLILPVINgPTEGLMLIYCAHFFTAIVGAEWWaqdfGKSIPFLSwvpfvseiqtyrivlFLMIAFAVIPTVA---FN 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901891 262 CTNYFRVIftggVGKNGSTIAGTSVLSPF-LHIGSVITLAAMiykkSAVQLFEKHPCLYILTFGFVSAKITNKLVVAHM- 339
Cdd:PLN02359 238 VSNVYKVV----QARKGSMLLALAMLYPFvTLLGGVLIWDYL----SPSDLMRNYPHLVVLGTGLAFGFLVGRMILAHLc 309
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767901891 340 -------TKSEMHLHDTAF-IGPALLFLDQYFNSFIDEYIVLWIALVFSFFDLIRYCVSVCNQIASHLHIHVFRIK 407
Cdd:PLN02359 310 depkglkTNMCMSLLYLPFaIANALTARLNDGVPLVDEFWVLLGYCAFTVSLYLHFATSVIHEITTALGIYCFRIT 385
EPT1 COG5050
sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferases [Lipid transport and ...
56-209 1.25e-25

sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferases [Lipid transport and metabolism];


Pssm-ID: 444050  Cd Length: 176  Bit Score: 102.07  E-value: 1.25e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901891  56 YQSAGRSLLEPLMQGY-WEWLVRRVPSWIAPNLITIIGLSINICTTILLVFYCPTATeqAPLWAyiaCACGLFIYQSLDA 134
Cdd:COG5050    8 YSVRDRSLLLAFLERYfLRWLAARLPAWVTPNLLTASGALGALAIFVGYLASNGDTG--AYLWL---APVGLIVYWFGDS 82
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767901891 135 IDGKQARRTNSSSPLGELFDHGCDSLSTVFVVLGTCIAvqLGTNPDWMFFCCFAGTFMFYCAHWQTYVSGTLRFG 209
Cdd:COG5050   83 LDGSLARRTGISRPYGEFLDHSLDALATLLIVIGLGLS--PYVRLDVALLALLGYLLLSIHTFWETRVTGEFRLG 155
CDP-OH_P_transf pfam01066
CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the ...
82-192 6.13e-06

CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond.


Pssm-ID: 460049 [Multi-domain]  Cd Length: 157  Bit Score: 46.01  E-value: 6.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901891   82 WIAPNLITIIGLsinICTTILLVFYcptateQAPLWAYIACACgLFIYQSLDAIDGKQARRTNSSSPLGELFDHGCDSLS 161
Cdd:pfam01066   1 LNLPNLLTLLRI---LLVPVFVVLL------LGPGNRILAAVV-FALAALTDFLDGKIARKLNQVTDFGKFLDPLADKLL 70
                          90       100       110
                  ....*....|....*....|....*....|.
gi 767901891  162 TVFVVLGTCIAVQLgtnPDWMFFCCFAGTFM 192
Cdd:pfam01066  71 VAAALIALSILGLL---PWWFVVVILVRELG 98
pgsA TIGR00560
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Alternate names: ...
85-184 1.03e-03

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Alternate names: phosphatidylglycerophosphate synthase; glycerophosphate phosphatidyltransferase; PGP synthase. A number of related enzymes are quite similar in both sequence and catalytic activity, including Saccharamyces cerevisiae YDL142c, now known to be a cardiolipin synthase. There may be problems with incorrect transitive annotation of near homologs as authentic CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 273139 [Multi-domain]  Cd Length: 182  Bit Score: 40.03  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901891   85 PNLITIigLSINICTTILLVFYCPTATEQAPLWAyiacACGLFIYQSL-DAIDGKQARRTNSSSPLGELFDHGCDSL--S 161
Cdd:TIGR00560   4 PNWLTL--FRIIALPIFILFFLENVLPIQVSPFI----GALLFIFAAVtDWLDGYLARKWNQVSNFGKFLDPLADKVlvL 77
                          90       100
                  ....*....|....*....|...
gi 767901891  162 TVFVVLgtciaVQLGTNPDWMFF 184
Cdd:TIGR00560  78 AVLIIL-----VYHGYVPAWFVI 95
 
Name Accession Description Interval E-value
PLN02359 PLN02359
ethanolaminephosphotransferase
43-407 4.88e-42

ethanolaminephosphotransferase


Pssm-ID: 166000  Cd Length: 389  Bit Score: 152.24  E-value: 4.88e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901891  43 LSRHQLKRLEEHRYQSAGRSLLEP-LMQGYWEWLVRRVPSWIAPNLITIIGLSINICTTILLVFYCPTATEQAPLWAYIA 121
Cdd:PLN02359   4 IGAHGVAALHRYKYSGVDHSYVAKyVLQPFWSRFVNFFPLWMPPNMITLMGFMFLLTSALLGYIYSPHLDTPPPRWVHFA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901891 122 CACGLFIYQSLDAIDGKQARRTNSSSPLGELFDHGCDSLSTVFVVLGTCIAVQLGTnpdWMFFCCFAGTFMFYCAHWQTY 201
Cdd:PLN02359  84 HGLLLFLYQTFDAVDGKQARRTNSSSPLGELFDHGCDALACAFETMAFGSTAMCGR---DTFWFWVISAVPFYGATWEHF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901891 202 VSGTLRFGIFD-VTESQIIIIICQLLTGTLGPWFW----NFTIPVLN---------------IQMKIFPALCTVAgtiFS 261
Cdd:PLN02359 161 FTNTLILPVINgPTEGLMLIYCAHFFTAIVGAEWWaqdfGKSIPFLSwvpfvseiqtyrivlFLMIAFAVIPTVA---FN 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901891 262 CTNYFRVIftggVGKNGSTIAGTSVLSPF-LHIGSVITLAAMiykkSAVQLFEKHPCLYILTFGFVSAKITNKLVVAHM- 339
Cdd:PLN02359 238 VSNVYKVV----QARKGSMLLALAMLYPFvTLLGGVLIWDYL----SPSDLMRNYPHLVVLGTGLAFGFLVGRMILAHLc 309
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767901891 340 -------TKSEMHLHDTAF-IGPALLFLDQYFNSFIDEYIVLWIALVFSFFDLIRYCVSVCNQIASHLHIHVFRIK 407
Cdd:PLN02359 310 depkglkTNMCMSLLYLPFaIANALTARLNDGVPLVDEFWVLLGYCAFTVSLYLHFATSVIHEITTALGIYCFRIT 385
PTZ00307 PTZ00307
ethanolamine phosphotransferase; Provisional
21-407 4.71e-39

ethanolamine phosphotransferase; Provisional


Pssm-ID: 140328  Cd Length: 417  Bit Score: 144.98  E-value: 4.71e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901891  21 GFGHMSTTGCVLNKLFQLPTPPlsrHQLKRLEEHRYQSAGRSLLEP-LMQGYWEWLVRRVPSWIAPNLITIIGLSINICT 99
Cdd:PTZ00307   1 MPPKSTARRISLNPLENEYIPP---AYLPNLKKYKYSSTDSSIISRyVLQRYWNFIVNLVPMTVAPNCITFTGFLIGMSS 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901891 100 TILLVFYCPTATEQAPLWAYIACACGLFIYQSLDAIDGKQARRTNSSSPLGELFDHGCDSLSTVFVVLGTCIAVQLgtnP 179
Cdd:PTZ00307  78 AALLLYFYFFEEGVYPSWVLYYAAFALFAYQTLDAIDGKQARRTGTGSPLGELFDHGCDAFLTPFVLLNVSLATYM---T 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901891 180 DWMFFCCFA-GTFMFYCAHWQTYVSGTLRFG-IFDVTESQIIIIICQLLTGTLGPWFWN------FTIPVLNIQMKIFPA 251
Cdd:PTZ00307 155 PVERFWLSTiSSMSLFTAIWEQFSTGTFDLGyVNGPTEGIILNCVLFIVSGVYGESIWDtpavgpYDVAYPPVLSSFFPG 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901891 252 ----------------LCTVAGTIFSCTNYFRVIFTGGVGKNGSTiagtsvlsPFLHIGSVITLAAMIYKKSAV--QLFE 313
Cdd:PTZ00307 235 csgtvhiesvrsvlflLFLVSCPFTILTNVVHVVLRPTVHASKVT--------PMLAALPILTMTALHVHVFVVfpNLHV 306
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901891 314 KHPCLYILTFGFVSAKITNKLVVAHMTKSEMHLHDTAFI------GPALLFLDQYFNSFIDEYI--VLWIAL----VFSF 381
Cdd:PTZ00307 307 KFPFALELSYGLLMSITVTRLTLARLSAMPYRTFNWHIVitflalTAASLMHYAGDASVEHKYVepSLGWALtglaVFAA 386
                        410       420
                 ....*....|....*....|....*.
gi 767901891 382 FDLIRYCVSVCNQIASHLHIHVFRIK 407
Cdd:PTZ00307 387 WQYGHMILSAFTQIARYLSISIMSIK 412
EPT1 COG5050
sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferases [Lipid transport and ...
56-209 1.25e-25

sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferases [Lipid transport and metabolism];


Pssm-ID: 444050  Cd Length: 176  Bit Score: 102.07  E-value: 1.25e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901891  56 YQSAGRSLLEPLMQGY-WEWLVRRVPSWIAPNLITIIGLSINICTTILLVFYCPTATeqAPLWAyiaCACGLFIYQSLDA 134
Cdd:COG5050    8 YSVRDRSLLLAFLERYfLRWLAARLPAWVTPNLLTASGALGALAIFVGYLASNGDTG--AYLWL---APVGLIVYWFGDS 82
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767901891 135 IDGKQARRTNSSSPLGELFDHGCDSLSTVFVVLGTCIAvqLGTNPDWMFFCCFAGTFMFYCAHWQTYVSGTLRFG 209
Cdd:COG5050   83 LDGSLARRTGISRPYGEFLDHSLDALATLLIVIGLGLS--PYVRLDVALLALLGYLLLSIHTFWETRVTGEFRLG 155
PLN03039 PLN03039
ethanolaminephosphotransferase; Provisional
91-406 2.16e-25

ethanolaminephosphotransferase; Provisional


Pssm-ID: 166679  Cd Length: 337  Bit Score: 105.85  E-value: 2.16e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901891  91 IGLSINICTTILLVFYCPTATEQAPLWAYIACACGLFIYQSLDAIDGKQARRTNSSSPLGELFDHGCDSLSTVFVVLGTC 170
Cdd:PLN03039   1 MGFMFLLTSALLGYIYSPKLDSPPPRWVHFAHGLLLFLYQTFDAVDGKQARRTNSSSPLGELFDHGCDALACAFEAMAFG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901891 171 IAVQLGTNPDWMFFCcfaGTFMFYCAHWQTYVSGTLRFGIFD-VTESQIIIIICQLLTGTLGPWFWN---------FT-I 239
Cdd:PLN03039  81 STAMCGRDTFWFWVI---SAIPFFGATWEHYFTNTLILPVINgPTEGLALIFCGHFFTAIVGAEWWAqpfgksiplFSwV 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901891 240 PVLN---------IQMKIFPALCTVAgtiFSCTNYFRVIFTggvgKNGSTIAGTSVLSPFLhigsVITLAAMIYKK-SAV 309
Cdd:PLN03039 158 PFLNeiqmsrailFMMIAFAVIPTLA---FNTSNVYKVVHS----RNGSMLLALAMLYPFV----TLIAGVLIWDYlSPI 226
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901891 310 QLFEKHPCLYILTFGFVSAKITNKLVVAHMTKSEMHLHDTAFIgpALLFLDQYFNSFIDEYIVLWIALVFSFFDLIRYCV 389
Cdd:PLN03039 227 DLIANYPHLVVLGTGLAFGFLVGRMILAHLCDEPKGLKTNMCM--SLLYLPFALANALTARLNAGVPLVDEFWVLLGYCI 304
                        330       340
                 ....*....|....*....|....*...
gi 767901891 390 -----------SVCNQIASHLHIHVFRI 406
Cdd:PLN03039 305 ftlslyahfatSVIHEITEALGIYCFRI 332
PgsA COG0558
Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; ...
82-192 2.22e-10

Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; Phosphatidylglycerophosphate synthase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440324 [Multi-domain]  Cd Length: 177  Bit Score: 59.10  E-value: 2.22e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901891  82 WIAPNLITIIGLsinICTTILLVFYcptATEQAPLWAyiacACGLFIYQSLDAIDGKQARRTNSSSPLGELFDHGCDSLS 161
Cdd:COG0558    9 LNIPNQLTLLRI---LLVPVFALLL---LLGGALLLA----LVLFLLAGLTDALDGYLARRLGQVSRFGAFLDPVADKLL 78
                         90       100       110
                 ....*....|....*....|....*....|.
gi 767901891 162 TVFVVLGtciAVQLGTNPDWMFFCCFAGTFM 192
Cdd:COG0558   79 DAAALLG---LVLLGLLPAWLALLILLRELL 106
CDP-OH_P_transf pfam01066
CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the ...
82-192 6.13e-06

CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond.


Pssm-ID: 460049 [Multi-domain]  Cd Length: 157  Bit Score: 46.01  E-value: 6.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901891   82 WIAPNLITIIGLsinICTTILLVFYcptateQAPLWAYIACACgLFIYQSLDAIDGKQARRTNSSSPLGELFDHGCDSLS 161
Cdd:pfam01066   1 LNLPNLLTLLRI---LLVPVFVVLL------LGPGNRILAAVV-FALAALTDFLDGKIARKLNQVTDFGKFLDPLADKLL 70
                          90       100       110
                  ....*....|....*....|....*....|.
gi 767901891  162 TVFVVLGTCIAVQLgtnPDWMFFCCFAGTFM 192
Cdd:pfam01066  71 VAAALIALSILGLL---PWWFVVVILVRELG 98
PssA COG1183
Phosphatidylserine synthase [Lipid transport and metabolism];
77-217 1.15e-05

Phosphatidylserine synthase [Lipid transport and metabolism];


Pssm-ID: 440796 [Multi-domain]  Cd Length: 237  Bit Score: 46.35  E-value: 1.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901891  77 RRVPSWIAPNLITIIGLsinICTTILLVFycptATEQAPLWAYIACACGLFiyqsLDAIDGKQARRTNSSSPLGELFDHG 156
Cdd:COG1183    5 RRRAIYLLPNLFTLLNL---FCGFLAIVA----AIEGDFELAALLILLAAV----FDGLDGRVARLLNVQSEFGAELDSL 73
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767901891 157 CDSLStvFVVLGTCIAVQLGTNPD--WMFFCCFagtfmFYCAhwqtyvSGTLRFGIFDVTESQ 217
Cdd:COG1183   74 ADMVS--FGVAPALLLYQWGLLPLggLGWLAAF-----LFAA------CSALRLARFNVKTDD 123
pgsA TIGR00560
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Alternate names: ...
85-184 1.03e-03

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Alternate names: phosphatidylglycerophosphate synthase; glycerophosphate phosphatidyltransferase; PGP synthase. A number of related enzymes are quite similar in both sequence and catalytic activity, including Saccharamyces cerevisiae YDL142c, now known to be a cardiolipin synthase. There may be problems with incorrect transitive annotation of near homologs as authentic CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 273139 [Multi-domain]  Cd Length: 182  Bit Score: 40.03  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901891   85 PNLITIigLSINICTTILLVFYCPTATEQAPLWAyiacACGLFIYQSL-DAIDGKQARRTNSSSPLGELFDHGCDSL--S 161
Cdd:TIGR00560   4 PNWLTL--FRIIALPIFILFFLENVLPIQVSPFI----GALLFIFAAVtDWLDGYLARKWNQVSNFGKFLDPLADKVlvL 77
                          90       100
                  ....*....|....*....|...
gi 767901891  162 TVFVVLgtciaVQLGTNPDWMFF 184
Cdd:TIGR00560  78 AVLIIL-----VYHGYVPAWFVI 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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