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Conserved domains on  [gi|767439467|gb|AIP65620|]
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glycosyl transferase family A [Burkholderia thailandensis]

Protein Classification

glycosyltransferase family 2 protein( domain architecture ID 11421525)

glycosyltransferase family 2 protein catalyzes the transfer of saccharide moieties from a donor to an acceptor to form glycosidic bonds

CAZY:  GT2
EC:  2.4.-.-
Gene Ontology:  GO:0016757
PubMed:  16037492|18518825

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 7-169 7.18e-14

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 70.50  E-value: 7.18e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767439467   7 PLVSVVCPTWQRRAFLPYLVYMFQYQDYPanRRELVILDD-SPDSSQDLVEQLAAADPAgsvIRYYHVAERMTIGAKRNR 85
Cdd:COG0463    2 PLVSVVIPTYNEEEYLEEALESLLAQTYP--DFEIIVVDDgSTDGTAEILRELAAKDPR---IRVIRLERNRGKGAARNA 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767439467  86 LNELARGDYIVCMDDDDYYPPDKVSHAVRAMQERCA-------TFSGSDQIYIWYSHIDRIYQTYSFGPHHALNGTFAYH 158
Cdd:COG0463   77 GLAAARGDYIAFLDADDQLDPEKLEELVAALEEGPAdlvygsrLIREGESDLRRLGSRLFNLVRLLTNLPDSTSGFRLFR 156

                        170
                 ....*....|.
gi 767439467 159 RQYLAHHRYDD 169
Cdd:COG0463  157 REVLEELGFDE 167
 
Name Accession Description Interval E-value
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 7-169 7.18e-14

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 70.50  E-value: 7.18e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767439467   7 PLVSVVCPTWQRRAFLPYLVYMFQYQDYPanRRELVILDD-SPDSSQDLVEQLAAADPAgsvIRYYHVAERMTIGAKRNR 85
Cdd:COG0463    2 PLVSVVIPTYNEEEYLEEALESLLAQTYP--DFEIIVVDDgSTDGTAEILRELAAKDPR---IRVIRLERNRGKGAARNA 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767439467  86 LNELARGDYIVCMDDDDYYPPDKVSHAVRAMQERCA-------TFSGSDQIYIWYSHIDRIYQTYSFGPHHALNGTFAYH 158
Cdd:COG0463   77 GLAAARGDYIAFLDADDQLDPEKLEELVAALEEGPAdlvygsrLIREGESDLRRLGSRLFNLVRLLTNLPDSTSGFRLFR 156

                        170
                 ....*....|.
gi 767439467 159 RQYLAHHRYDD 169
Cdd:COG0463  157 REVLEELGFDE 167
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 10-98 7.68e-08

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 52.01  E-value: 7.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767439467   10 SVVCPTWQRRAFLPYLVYMFQYQDYPanRRELVILDD-SPDSSQDLVEQLAAADPagsVIRYYHVAERMTIGAKRNRLNE 88
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNQTYP--NFEIIVVDDgSTDGTVEIAEEYAKKDP---RVRVIRLPENRGKAGARNAGLR 75

                          90
                  ....*....|
gi 767439467   89 LARGDYIVCM 98
Cdd:pfam00535  76 AATGDYIAFL 85
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 8-98 1.01e-06

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 49.92  E-value: 1.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767439467   8 LVSVVCPTWQRRAFLPYLVYMFQYQDYPANRRELVILDD-SPDSSQDLVEQLAAADPAgsvIRYYHVAERmTIGAKRNRL 86
Cdd:cd02525    1 FVSIIIPVRNEEKYIEELLESLLNQSYPKDLIEIIVVDGgSTDGTREIVQEYAAKDPR---IRLIDNPKR-IQSAGLNIG 76

                         90
                 ....*....|..
gi 767439467  87 NELARGDYIVCM 98
Cdd:cd02525   77 IRNSRGDIIIRV 88
PLN02726 PLN02726
dolichyl-phosphate beta-D-mannosyltransferase
 7-98 1.59e-04

dolichyl-phosphate beta-D-mannosyltransferase


Pssm-ID: 215385 [Multi-domain]  Cd Length: 243  Bit Score: 43.15  E-value: 1.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767439467   7 PLVSVVCPTWQRRAFLPYLVYMFQYQDYPANRRELVILDD-SPDSSQDLVEQLAAAdpagsviryyHVAERMTIGAKRNR 85
Cdd:PLN02726   9 MKYSIIVPTYNERLNIALIVYLIFKALQDVKDFEIIVVDDgSPDGTQDVVKQLQKV----------YGEDRILLRPRPGK 78

                         90       100
                 ....*....|....*....|..
gi 767439467  86 LN---------ELARGDYIVCM 98
Cdd:PLN02726  79 LGlgtayihglKHASGDFVVIM 100
 
Name Accession Description Interval E-value
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 7-169 7.18e-14

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 70.50  E-value: 7.18e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767439467   7 PLVSVVCPTWQRRAFLPYLVYMFQYQDYPanRRELVILDD-SPDSSQDLVEQLAAADPAgsvIRYYHVAERMTIGAKRNR 85
Cdd:COG0463    2 PLVSVVIPTYNEEEYLEEALESLLAQTYP--DFEIIVVDDgSTDGTAEILRELAAKDPR---IRVIRLERNRGKGAARNA 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767439467  86 LNELARGDYIVCMDDDDYYPPDKVSHAVRAMQERCA-------TFSGSDQIYIWYSHIDRIYQTYSFGPHHALNGTFAYH 158
Cdd:COG0463   77 GLAAARGDYIAFLDADDQLDPEKLEELVAALEEGPAdlvygsrLIREGESDLRRLGSRLFNLVRLLTNLPDSTSGFRLFR 156

                        170
                 ....*....|.
gi 767439467 159 RQYLAHHRYDD 169
Cdd:COG0463  157 REVLEELGFDE 167
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 4-98 3.01e-10

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 61.30  E-value: 3.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767439467   4 DAFPLVSVVCPTWQRRAFLPYLVYMFQYQDYPANRRELVILDD-SPDSSQDLVEQLAAADPAgsvIRYYHVAERMTIGAK 82
Cdd:COG1215   26 ADLPRVSVIIPAYNEEAVIEETLRSLLAQDYPKEKLEVIVVDDgSTDETAEIARELAAEYPR---VRVIERPENGGKAAA 102

                         90
                 ....*....|....*.
gi 767439467  83 RNRLNELARGDYIVCM 98
Cdd:COG1215  103 LNAGLKAARGDIVVFL 118
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 10-98 7.68e-08

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 52.01  E-value: 7.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767439467   10 SVVCPTWQRRAFLPYLVYMFQYQDYPanRRELVILDD-SPDSSQDLVEQLAAADPagsVIRYYHVAERMTIGAKRNRLNE 88
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNQTYP--NFEIIVVDDgSTDGTVEIAEEYAKKDP---RVRVIRLPENRGKAGARNAGLR 75

                          90
                  ....*....|
gi 767439467   89 LARGDYIVCM 98
Cdd:pfam00535  76 AATGDYIAFL 85
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 8-98 1.01e-06

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 49.92  E-value: 1.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767439467   8 LVSVVCPTWQRRAFLPYLVYMFQYQDYPANRRELVILDD-SPDSSQDLVEQLAAADPAgsvIRYYHVAERmTIGAKRNRL 86
Cdd:cd02525    1 FVSIIIPVRNEEKYIEELLESLLNQSYPKDLIEIIVVDGgSTDGTREIVQEYAAKDPR---IRLIDNPKR-IQSAGLNIG 76

                         90
                 ....*....|..
gi 767439467  87 NELARGDYIVCM 98
Cdd:cd02525   77 IRNSRGDIIIRV 88
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 11-98 1.29e-06

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 48.27  E-value: 1.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767439467  11 VVCPTWQRRAFLPYLVYMFQYQDYPanRRELVILDD-SPDSSQDLVEQLAAADPagsVIRYYHVAERMTIGAKRNRLNEL 89
Cdd:cd00761    1 VIIPAYNEEPYLERCLESLLAQTYP--NFEVIVVDDgSTDGTLEILEEYAKKDP---RVIRVINEENQGLAAARNAGLKA 75


                 ....*....
gi 767439467  90 ARGDYIVCM 98
Cdd:cd00761   76 ARGEYILFL 84
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
7-98 4.28e-06

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 47.29  E-value: 4.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767439467   7 PLVSVVCPTWQRRAFLPYLVYMFQYQDYPanRRELVILDD-SPDSSQDLVEQLAAADpagsvIRYYHVAERMTIGAKRNR 85
Cdd:COG1216    3 PKVSVVIPTYNRPELLRRCLESLLAQTYP--PFEVIVVDNgSTDGTAELLAALAFPR-----VRVIRNPENLGFAAARNL 75

                         90
                 ....*....|...
gi 767439467  86 LNELARGDYIVCM 98
Cdd:COG1216   76 GLRAAGGDYLLFL 88
PLN02726 PLN02726
dolichyl-phosphate beta-D-mannosyltransferase
 7-98 1.59e-04

dolichyl-phosphate beta-D-mannosyltransferase


Pssm-ID: 215385 [Multi-domain]  Cd Length: 243  Bit Score: 43.15  E-value: 1.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767439467   7 PLVSVVCPTWQRRAFLPYLVYMFQYQDYPANRRELVILDD-SPDSSQDLVEQLAAAdpagsviryyHVAERMTIGAKRNR 85
Cdd:PLN02726   9 MKYSIIVPTYNERLNIALIVYLIFKALQDVKDFEIIVVDDgSPDGTQDVVKQLQKV----------YGEDRILLRPRPGK 78

                         90       100
                 ....*....|....*....|..
gi 767439467  86 LN---------ELARGDYIVCM 98
Cdd:PLN02726  79 LGlgtayihglKHASGDFVVIM 100
PRK10018 PRK10018
colanic acid biosynthesis glycosyltransferase WcaA;
7-98 2.23e-04

colanic acid biosynthesis glycosyltransferase WcaA;


Pssm-ID: 182197 [Multi-domain]  Cd Length: 279  Bit Score: 43.06  E-value: 2.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767439467   7 PLVSVVCPTWQRRAFLPYLVYMFQYQDYPanRRELVILDDSPDSSQDL---VEQLAaaDPAgsvIRYYHVAERMTIGAKR 83
Cdd:PRK10018   5 PLISIYMPTWNRQQLAIRAIKSVLRQDYS--NWEMIIVDDCSTSWEQLqqyVTALN--DPR---ITYIHNDINSGACAVR 77

                         90
                 ....*....|....*
gi 767439467  84 NRLNELARGDYIVCM 98
Cdd:PRK10018  78 NQAIMLAQGEYITGI 92
DPM1_like cd06442
DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to ...
 41-98 1.85e-03

DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to eukaryotic DPM1, including enzymes from bacteria and archaea; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133062 [Multi-domain]  Cd Length: 224  Bit Score: 39.82  E-value: 1.85e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767439467  41 LVILDDSPDSSQDLVEQLAAADPAGSVIRyyhvaermtigakrnRLNEL------------ARGDYIVCM 98
Cdd:cd06442   31 IVVDDNSPDGTAEIVRELAKEYPRVRLIV---------------RPGKRglgsayiegfkaARGDVIVVM 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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