|
Name |
Accession |
Description |
Interval |
E-value |
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
348-980 |
3.63e-170 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 520.79 E-value: 3.63e-170
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 348 EQLPVFRCRSQLLSLIRENQVVVIIGETGSGKTTQLAQYLYEEGYAndRGKSIVVTQPRRVAAMSVAKRVAMEMQVPLGK 427
Cdd:COG1643 8 PDLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLELGWG--AGGRIGMLEPRRLAARAAAERMAEELGEPVGE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 428 EVGYSVRFEDVTdSECTKLKFVTDGILLRETLLDDTLDKYSCVIIDEAHERSLNTDILLGFFKILLARRR-DLKLIITSA 506
Cdd:COG1643 86 TVGYRVRFEDKV-SAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQPALRpDLKLLVMSA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 507 TMNAKKFSAFFGNAPQFTIPGRTFPVQTIYTS-NPVQDYVEAAVSQAVKIHLANDcsSGDILIFMTGQEDIETTFDTLQE 585
Cdd:COG1643 165 TLDAERFARLLGDAPVIESSGRTYPVEVRYRPlPADERDLEDAVADAVREALAEE--PGDILVFLPGEREIRRTAEALRG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 586 KFLQvyskkfgtanfeeinDIEILPIYSALPADLQFKIFQDLHGTKRKIIIATNIAETSLTIKGIRYVIDCGYSKLKVYN 665
Cdd:COG1643 243 RLPP---------------DTEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYD 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 666 PKIGLDSLVITPISKANADQRSGRAGRTAPGTAYRLYTEDTFkEDMYLQTIPEIQRtnlsntllllksldvTD------- 738
Cdd:COG1643 308 PRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDF-ARRPAFTDPEILR---------------ADlaslile 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 739 -------ELSKFPFIDKPP---LQTFLSSLYELwfiGAIDTRGQLTPLGLQMAKFPLQPSLSKILLIAVRNGCSDEMLTI 808
Cdd:COG1643 372 laawglgDPEDLPFLDPPParaIADARALLQEL---GALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAIL 448
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 809 VSMLSVPqvfyrpkerqkeaDIARNKffiAKSDHLTLLNVFEQWRANnfsshwcNKHFVQYKSLVRARDIRDQLLTILKS 888
Cdd:COG1643 449 AALLSER-------------DPRRGA---AGSDLLARLNLWRRLREQ-------QREFLSYLRLREWRDLARQLRRLLGE 505
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 889 QKipvISSGKDWDIIKKCICSGFAHQ-AAKITGLRNYVhLKTGVSVQLHPTSALHGlgdlPPYVVYHELLMTSKEY-ICC 966
Cdd:COG1643 506 GA---NEEPADYEAIGLLLALAYPDRiARRRGEGGRYL-LARGRGAALFPGSPLAK----KEWLVAAELVGGAAEArIRL 577
|
650
....*....|....
gi 767155161 967 VTSVDPFWLMEYGG 980
Cdd:COG1643 578 AAPIDPEWLEELAA 591
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
348-975 |
1.16e-135 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 442.19 E-value: 1.16e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 348 EQLPVFRCRSQLLSLIRENQVVVIIGETGSGKTTQLAQYLYEEGyandRGKS--IVVTQPRRVAAMSVAKRVAMEMQVPL 425
Cdd:PRK11131 71 ENLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLELG----RGVKglIGHTQPRRLAARTVANRIAEELETEL 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 426 GKEVGYSVRFEDVTdSECTKLKFVTDGILLRETLLDDTLDKYSCVIIDEAHERSLNTDILLGFFKILLARRRDLKLIITS 505
Cdd:PRK11131 147 GGCVGYKVRFNDQV-SDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPDLKVIITS 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 506 ATMNAKKFSAFFGNAPQFTIPGRTFPVQTIY------TSNPVQDYVEaAVSQAVKiHLANDcSSGDILIFMTGQEDIETT 579
Cdd:PRK11131 226 ATIDPERFSRHFNNAPIIEVSGRTYPVEVRYrpiveeADDTERDQLQ-AIFDAVD-ELGRE-GPGDILIFMSGEREIRDT 302
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 580 FDTLQEKFLQvyskkfgtanfeeinDIEILPIYSALPADLQFKIFQDLHGtkRKIIIATNIAETSLTIKGIRYVIDCGYS 659
Cdd:PRK11131 303 ADALNKLNLR---------------HTEILPLYARLSNSEQNRVFQSHSG--RRIVLATNVAETSLTVPGIKYVIDPGTA 365
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 660 KLKVYNPKIGLDSLVITPISKANADQRSGRAGRTAPGTAYRLYTEDTFKEDMYLqTIPEIQRTNLSNTLLLLKSLDVTDe 739
Cdd:PRK11131 366 RISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFLSRPEF-TDPEILRTNLASVILQMTALGLGD- 443
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 740 LSKFPFIDKPP---LQTFLSSLYELwfiGAIDTRG-----QLTPLGLQMAKFPLQPSLSKILLIAVRNGCSDEMLTIVSM 811
Cdd:PRK11131 444 IAAFPFVEAPDkrnIQDGVRLLEEL---GAITTDEqasayKLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITSA 520
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 812 LSVPQVFYRPKERQKEADIARNKFFIAKSDHLTLLNVF----EQWRA---NNFSSHwCNKHFVQYKSLVRARDIRDQLLT 884
Cdd:PRK11131 521 LSIQDPRERPMDKQQASDEKHRRFADKESDFLAFVNLWnylqEQQKAlssNQFRRL-CRTDYLNYLRVREWQDIYTQLRQ 599
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 885 ILKSQKIPVISSGKDWDIIKKCICSG-FAHQAAK------ITGLRNyvhlktgVSVQLHPTSalhGLGDLPP-YVVYHEL 956
Cdd:PRK11131 600 VVKELGIPVNSEPAEYREIHTALLTGlLSHIGMKdaekqeYTGARN-------ARFSIFPGS---GLFKKPPkWVMVAEL 669
|
650
....*....|....*....
gi 767155161 957 LMTSKEYICCVTSVDPFWL 975
Cdd:PRK11131 670 VETSRLWGRIAARIEPEWI 688
|
|
| DEXHc_DHX38 |
cd17983 |
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ... |
350-525 |
3.73e-91 |
|
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350741 [Multi-domain] Cd Length: 173 Bit Score: 288.59 E-value: 3.73e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 350 LPVFRCRSQLLSLIRENQVVVIIGETGSGKTTQLAQYLYEEGYAnDRGKsIVVTQPRRVAAMSVAKRVAMEMQVPLGKEV 429
Cdd:cd17983 1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHEDGYT-DYGM-IGCTQPRRVAAMSVAKRVSEEMGVELGEEV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 430 GYSVRFEDVTdSECTKLKFVTDGILLRETLLDDTLDKYSCVIIDEAHERSLNTDILLGFFKILLARRRDLKLIITSATMN 509
Cdd:cd17983 79 GYAIRFEDCT-SENTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRDLKLIVTSATMD 157
|
170
....*....|....*.
gi 767155161 510 AKKFSAFFGNAPQFTI 525
Cdd:cd17983 158 ADKFADFFGNVPIFTI 173
|
|
| DEXHc_RHA-like |
cd17917 |
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ... |
366-525 |
4.64e-89 |
|
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438707 [Multi-domain] Cd Length: 159 Bit Score: 282.43 E-value: 4.64e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 366 NQVVVIIGETGSGKTTQLAQYLYEEGYANDRGKSIVVTQPRRVAAMSVAKRVAMEMQVPLGKEVGYSVRFEDVTDSEcTK 445
Cdd:cd17917 1 NQVVVIVGETGSGKTTQVPQFLLEDGLAKGGKGRIVCTQPRRIAAISVAERVAEERGEKLGEEVGYQIRFESKTSSK-TR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 446 LKFVTDGILLRETLLDDTLDKYSCVIIDEAHERSLNTDILLGFFKILLARRRDLKLIITSATMNAKKFSAFFGNAPQFTI 525
Cdd:cd17917 80 IKFCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPDLKVILMSATLDAEKFSSYFGGAPVIHI 159
|
|
| DEAH_box_HrpB |
TIGR01970 |
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ... |
350-960 |
1.17e-85 |
|
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273901 [Multi-domain] Cd Length: 819 Bit Score: 295.14 E-value: 1.17e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 350 LPVFRCRSQLLSLIRENQVVVIIGETGSGKTTQLAQYLYEEGYAndrGKSIVVTQPRRVAAMSVAKRVAMEMQVPLGKEV 429
Cdd:TIGR01970 1 LPIHAVLPALRDALAAHPQVVLEAPPGAGKSTAVPLALLDAPGI---GGKIIMLEPRRLAARSAAQRLASQLGEAVGQTV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 430 GYSVRFEDVTdSECTKLKFVTDGILLRETLLDDTLDKYSCVIIDEAHERSLNTDILLGF-FKILLARRRDLKLIITSATM 508
Cdd:TIGR01970 78 GYRVRGENKV-SRRTRLEVVTEGILTRMIQDDPELDGVGALIFDEFHERSLDADLGLALaLDVQSSLREDLKILAMSATL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 509 NAKKFSAFFGNAPQFTIPGRTFPVQTIYTSNPVQDYVEAAVSQAVKIHLANDcsSGDILIFMTGQEDIETTFDTLQEKFl 588
Cdd:TIGR01970 157 DGERLSSLLPDAPVVESEGRSFPVEIRYLPLRGDQRLEDAVSRAVEHALASE--TGSILVFLPGQAEIRRVQEQLAERL- 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 589 qvyskkfgtanfeeINDIEILPIYSALPADLQFKIFQDLHGTKRKIIIATNIAETSLTIKGIRYVIDCGYSKLKVYNPKI 668
Cdd:TIGR01970 234 --------------DSDVLICPLYGELSLAAQDRAIKPDPQGRRKVVLATNIAETSLTIEGIRVVIDSGLARVARFDPKT 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 669 GLDSLVITPISKANADQRSGRAGRTAPGTAYRLYTEDTFKEdMYLQTIPEIQRTNLSNTLLLLKSLDVTDElSKFPFIDK 748
Cdd:TIGR01970 300 GITRLETVRISQASATQRAGRAGRLEPGVCYRLWSEEQHQR-LPAQDEPEILQADLSGLALELAQWGAKDP-SDLRWLDA 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 749 PPLQTFLSSLYELWFIGAIDTRGQLTPLGLQMAKFPLQPSLSKILLIAVRNGCSDEMLTIVSMLSVPQVfyrpkERQKEA 828
Cdd:TIGR01970 378 PPSVALAAARQLLQRLGALDAQGRLTAHGKAMAALGCHPRLAAMLLSAHSTGLAALACDLAALLEERGL-----PRQGGA 452
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 829 DIARnkffiaksdHLTLLNVFEQWRANnfsshwcnkhfvqykslvRARDIRDQLLTILKSQKIPviSSGKDWDIIKKCIC 908
Cdd:TIGR01970 453 DLMN---------RLHRLQQGRQGRGQ------------------RAQQLAKKLRRRLRFSQAD--SGAIASHALGLLLA 503
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|..
gi 767155161 909 SGFAHQAAKITGLRNYVHLKTGVSVQLHPTSALHGlgdlPPYVVYHELLMTS 960
Cdd:TIGR01970 504 LAFPDRIAKRRGQPGRYQLANGRGAVLSAEDALAR----EPWLVAADLGEGQ 551
|
|
| DEXHc_DHX33 |
cd17978 |
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ... |
350-521 |
6.71e-82 |
|
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438710 [Multi-domain] Cd Length: 178 Bit Score: 263.83 E-value: 6.71e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 350 LPVFRCRSQLLSLIRENQVVVIIGETGSGKTTQLAQYLYEEGYAndRGKSIVVTQPRRVAAMSVAKRVAMEMQVPLGKEV 429
Cdd:cd17978 1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEAGFA--RGGMIGITQPRRVAAVSVAKRVAEEMGVELGQLV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 430 GYSVRFEDVTdSECTKLKFVTDGILLRETLLDDTLDKYSCVIIDEAHERSLNTDILLGFFKILLARRRD-----LKLIIT 504
Cdd:cd17978 79 GYSVRFDDVT-SEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRKEqklspLKVIIM 157
|
170
....*....|....*..
gi 767155161 505 SATMNAKKFSAFFGNAP 521
Cdd:cd17978 158 SATLDADLFSEYFNGAP 174
|
|
| DEXHc_DHX8 |
cd17971 |
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ... |
347-526 |
7.10e-76 |
|
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350729 [Multi-domain] Cd Length: 179 Bit Score: 247.40 E-value: 7.10e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 347 KEQLPVFRCRSQLLSLIRENQVVVIIGETGSGKTTQLAQYLYEEGYANdRGKsIVVTQPRRVAAMSVAKRVAMEMQVPLG 426
Cdd:cd17971 3 RESLPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYLAEAGYTS-RGK-IGCTQPRRVAAMSVAKRVAEEFGCCLG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 427 KEVGYSVRFEDVTDSEcTKLKFVTDGILLRETLLDDTLDKYSCVIIDEAHERSLNTDILLGFFKILLARRRDLKLIITSA 506
Cdd:cd17971 81 QEVGYTIRFEDCTSPE-TVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQKRPDLKLIVTSA 159
|
170 180
....*....|....*....|
gi 767155161 507 TMNAKKFSAFFGNAPQFTIP 526
Cdd:cd17971 160 TLDAVKFSQYFYEAPIFTIP 179
|
|
| DEXHc_DHX15 |
cd17973 |
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ... |
342-525 |
4.92e-74 |
|
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438709 [Multi-domain] Cd Length: 187 Bit Score: 242.71 E-value: 4.92e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 342 DIKHTKEQLPVFRCRSQLLSLIRENQVVVIIGETGSGKTTQLAQYLYEEGYANDRGKSIVVTQPRRVAAMSVAKRVAMEM 421
Cdd:cd17973 5 EILEKRRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDDELPHQPKKLVACTQPRRVAAMSVAQRVAEEM 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 422 QVPLGKEVGYSVRFEDVTdSECTKLKFVTDGILLRETLLDDTLDKYSCVIIDEAHERSLNTDILLGFFKILLARRRDLKL 501
Cdd:cd17973 85 DVKLGEEVGYSIRFEDCS-SAKTILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEVVRRRPDLKL 163
|
170 180
....*....|....*....|....
gi 767155161 502 IITSATMNAKKFSAFFGNAPQFTI 525
Cdd:cd17973 164 IVMSATLDAGKFQKYFDNAPLLKV 187
|
|
| DEXHc_DHX16 |
cd17974 |
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ... |
350-525 |
5.87e-74 |
|
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350732 [Multi-domain] Cd Length: 174 Bit Score: 242.02 E-value: 5.87e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 350 LPVFRCRSQLLSLIRENQVVVIIGETGSGKTTQLAQYLYEEGYANDRGKsIVVTQPRRVAAMSVAKRVAMEMQVPLGKEV 429
Cdd:cd17974 1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEAGYTKGGGK-IGCTQPRRVAAMSVAARVAEEMGVKLGNEV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 430 GYSVRFEDVTdSECTKLKFVTDGILLRETLLDDTLDKYSCVIIDEAHERSLNTDILLGFFKILLARRRDLKLIITSATMN 509
Cdd:cd17974 80 GYSIRFEDCT-SEKTVLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPDLKLLISSATMD 158
|
170
....*....|....*.
gi 767155161 510 AKKFSAFFGNAPQFTI 525
Cdd:cd17974 159 AEKFSAFFDDAPIFRI 174
|
|
| PRK11664 |
PRK11664 |
ATP-dependent RNA helicase HrpB; Provisional |
349-831 |
3.12e-73 |
|
ATP-dependent RNA helicase HrpB; Provisional
Pssm-ID: 236950 [Multi-domain] Cd Length: 812 Bit Score: 259.86 E-value: 3.12e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 349 QLPVFRCRSQLLSLIRENQVVVIIGETGSGKTTQLAQYLYEEGYANDRgksIVVTQPRRVAAMSVAKRVAMEMQVPLGKE 428
Cdd:PRK11664 3 SLPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLPLQLLQHGGINGK---IIMLEPRRLAARNVAQRLAEQLGEKPGET 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 429 VGYSVRFEDVTdSECTKLKFVTDGILLRETLLDDTLDKYSCVIIDEAHERSLNTDILLGFfkiLL----ARRRDLKLIIT 504
Cdd:PRK11664 80 VGYRMRAESKV-GPNTRLEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADLALAL---LLdvqqGLRDDLKLLIM 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 505 SATMNAKKFSAFFGNAPQFTIPGRTFPVQTIYTSNPVQDYVEAAVSQAVKIHLANDcsSGDILIFMTGQEDIETTFDTLQ 584
Cdd:PRK11664 156 SATLDNDRLQQLLPDAPVIVSEGRSFPVERRYQPLPAHQRFDEAVARATAELLRQE--SGSLLLFLPGVGEIQRVQEQLA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 585 EKflqVYSkkfgtanfeeinDIEILPIYSALP-ADLQFKIFQDLHGtKRKIIIATNIAETSLTIKGIRYVIDCGYSKLKV 663
Cdd:PRK11664 234 SR---VAS------------DVLLCPLYGALSlAEQQKAILPAPAG-RRKVVLATNIAETSLTIEGIRLVVDSGLERVAR 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 664 YNPKIGLDSLVITPISKANADQRSGRAGRTAPGTAYRLYTEDTFkEDMYLQTIPEIQRTNLSNTLLLLKSLDVTDeLSKF 743
Cdd:PRK11664 298 FDPKTGLTRLVTQRISQASMTQRAGRAGRLEPGICLHLYSKEQA-ERAAAQSEPEILHSDLSGLLLELLQWGCHD-PAQL 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 744 PFIDKPPLQTFLSSLYELWFIGAIDTRGQLTPLGLQMAKFPLQPSLSKILLIAVRNgcSDEMLT----IVSMLSVPqvfy 819
Cdd:PRK11664 376 SWLDQPPAAALAAAKRLLQQLGALDGQGRLTARGRKMAALGNDPRLAAMLVAAKED--DEAALAtaakLAAILEEP---- 449
|
490
....*....|..
gi 767155161 820 rpkERQKEADIA 831
Cdd:PRK11664 450 ---PRSGSSDLG 458
|
|
| DEXHc_DHX35 |
cd17980 |
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ... |
350-517 |
1.30e-70 |
|
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350738 [Multi-domain] Cd Length: 185 Bit Score: 233.13 E-value: 1.30e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 350 LPVFRCRSQLLSLIRENQVVVIIGETGSGKTTQLAQYLYEEGYANDrGKSIVVTQPRRVAAMSVAKRVAMEMQVPLGKEV 429
Cdd:cd17980 1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAEAGWTAG-GRVVGCTQPRRVAAVTVAGRVAEEMGAVLGHEV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 430 GYSVRFEDVTDSECTKLKFVTDGILLRETLLDDTLDKYSCVIIDEAHERSLNTDILLGFFKILLARRRDLKLIITSATMN 509
Cdd:cd17980 80 GYCIRFDDCTDPQATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQKKRGDLRLIVASATLD 159
|
....*...
gi 767155161 510 AKKFSAFF 517
Cdd:cd17980 160 AEKFRDFF 167
|
|
| SF2_C_RHA |
cd18791 |
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
530-702 |
9.91e-70 |
|
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 230.11 E-value: 9.91e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 530 FPVQTIYTSNPVQ-----------DYVEAAVSQAVKIHlaNDCSSGDILIFMTGQEDIETTFDTLQEKFLQVYSKKFgta 598
Cdd:cd18791 1 FPVEVYYLEDILEllgissekedpDYVDAAVRLILQIH--RTEEPGDILVFLPGQEEIERLCELLREELLSPDLGKL--- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 599 nfeeindiEILPIYSALPADLQFKIFQDLHGTKRKIIIATNIAETSLTIKGIRYVIDCGYSKLKVYNPKIGLDSLVITPI 678
Cdd:cd18791 76 --------LVLPLHSSLPPEEQQRVFEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWI 147
|
170 180
....*....|....*....|....
gi 767155161 679 SKANADQRSGRAGRTAPGTAYRLY 702
Cdd:cd18791 148 SKASAEQRAGRAGRTRPGKCYRLY 171
|
|
| DEXHc_HrpA |
cd17989 |
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ... |
350-521 |
3.42e-63 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350747 [Multi-domain] Cd Length: 173 Bit Score: 211.93 E-value: 3.42e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 350 LPVFRCRSQLLSLIRENQVVVIIGETGSGKTTQLAQYLYEEGYANdRGKsIVVTQPRRVAAMSVAKRVAMEMQVPLGKEV 429
Cdd:cd17989 1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICLELGRGI-RGL-IGHTQPRRLAARSVAERIAEELKTELGGAV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 430 GYSVRFEDVTDSEcTKLKFVTDGILLRETLLDDTLDKYSCVIIDEAHERSLNTDILLGFFKILLARRRDLKLIITSATMN 509
Cdd:cd17989 79 GYKVRFTDQTSDE-TCVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKVIITSATID 157
|
170
....*....|..
gi 767155161 510 AKKFSAFFGNAP 521
Cdd:cd17989 158 AERFSRHFNNAP 169
|
|
| DEXHc_DHX40 |
cd17984 |
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ... |
350-525 |
4.56e-61 |
|
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350742 [Multi-domain] Cd Length: 178 Bit Score: 206.24 E-value: 4.56e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 350 LPVFRCRSQLLSLIRENQVVVIIGETGSGKTTQLAQYLYEEGYAndRGKSIVVTQPRRVAAMSVAKRVAMEMQVPLGKEV 429
Cdd:cd17984 1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFS--QHGMIGVTQPRRVAAISVAQRVAEEMKCTLGSKV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 430 GYSVRFEDVTdSECTKLKFVTDGILLRETLLDDTLDKYSCVIIDEAHERSLNTDILLGFFKILL-----ARRRDLKLIIT 504
Cdd:cd17984 79 GYQVRFDDCS-SKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKKLFqekspNRKEHLKVVVM 157
|
170 180
....*....|....*....|.
gi 767155161 505 SATMNAKKFSAFFGNAPQFTI 525
Cdd:cd17984 158 SATLELAKLSAFFGNCPVFDI 178
|
|
| DEXHc_DHX37 |
cd17982 |
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ... |
350-521 |
7.11e-60 |
|
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350740 [Multi-domain] Cd Length: 191 Bit Score: 203.35 E-value: 7.11e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 350 LPVFRCRSQLLSLIRENQVVVIIGETGSGKTTQLAQYLYEEGYAN---DRGKSIVVTQPRRVAAMSVAKRVAMEMQVPlG 426
Cdd:cd17982 1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEAGFGSpesDNPGMIGITQPRRVAAVSMAKRVAEELNVF-G 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 427 KEVGYSVRFEDvTDSECTKLKFVTDGILLRETLLDDTLDKYSCVIIDEAHERSLNTDILLGFF-KILLARR--------- 496
Cdd:cd17982 80 KEVSYQIRYDS-TVSENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLsRIVPLRAklylqdqtv 158
|
170 180
....*....|....*....|....*...
gi 767155161 497 RDLKLIITSATMNAKKFSA---FFGNAP 521
Cdd:cd17982 159 KPLKLVIMSATLRVEDFTEnklLFPRPP 186
|
|
| DEXHc_DHX34 |
cd17979 |
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ... |
350-521 |
5.72e-54 |
|
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350737 [Multi-domain] Cd Length: 170 Bit Score: 185.72 E-value: 5.72e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 350 LPVFRCRSQLLSLIRENQVVVIIGETGSGKTTQLAQYLYEEGYANdrgksIVVTQPRRVAAMSVAKRVAMEMQVPLGKEV 429
Cdd:cd17979 1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAAGFRH-----IACTQPRRIACISLAKRVAFESLNQYGSKV 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 430 GYSVRFEDvTDSECTKLKFVTDGILLRETLLDDTLDKYSCVIIDEAHERSLNTDILLGFFKILLARRRDLKLIITSATMN 509
Cdd:cd17979 76 AYQIRFER-TRTLATKLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPDLKLILMSATIN 154
|
170
....*....|..
gi 767155161 510 AKKFSAFFGNAP 521
Cdd:cd17979 155 IELFSGYFEGAP 166
|
|
| DEXHc_DHX36 |
cd17981 |
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ... |
350-525 |
3.69e-49 |
|
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350739 [Multi-domain] Cd Length: 180 Bit Score: 172.33 E-value: 3.69e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 350 LPVFRCRSQLLSLIRENQVVVIIGETGSGKTTQLAQYLYEEGYANDRGKS--IVVTQPRRVAAMSVAKRVAMEM--QVPL 425
Cdd:cd17981 1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFILDDAIERGKGSScrIVCTQPRRISAISVAERVAAERaeSCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 426 GKEVGYSVRFEDVTDSECTKLKFVTDGILLRETLLDDTLDKYSCVIIDEAHERSLNTDILLGFFKILLARRRDLKLIITS 505
Cdd:cd17981 81 GNSTGYQIRLESRKPRKQGSILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSDLKVILMS 160
|
170 180
....*....|....*....|
gi 767155161 506 ATMNAKKFSAFFGNAPQFTI 525
Cdd:cd17981 161 ATLNAEKFSDYFNNCPMIHI 180
|
|
| DEXHc_DHX9 |
cd17972 |
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ... |
318-525 |
1.51e-48 |
|
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350730 [Multi-domain] Cd Length: 234 Bit Score: 172.71 E-value: 1.51e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 318 NNKAKDKSNQKICDDTALftpskDDIKHTKEQLPVFRCRSQLLSLIRENQVVVIIGETGSGKTTQLAQYLYEEGYANDRG 397
Cdd:cd17972 32 SMDLKNELMYQREQDHNL-----QQILQERELLPVKKFREEILEAISNNPVVIIRGATGCGKTTQVPQYILDDFIQNDRA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 398 KS--IVVTQPRRVAAMSVAKRVAMEMQVPLGKEVGYSVRFEDVTDSECTKLKFVTDGILLREtlLDDTLDKYSCVIIDEA 475
Cdd:cd17972 107 AEcnIVVTQPRRISAVSVAERVAFERGEEVGKSCGYSVRFESVLPRPHASILFCTVGVLLRK--LEAGIRGISHVIVDEI 184
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 767155161 476 HERSLNTDILLGFFKILLARRRDLKLIITSATMNAKKFSAFFGNAPQFTI 525
Cdd:cd17972 185 HERDINTDFLLVVLRDVVQAYPDLRVILMSATIDTSMFCEYFFNCPVIEV 234
|
|
| DEXHc_DHX57 |
cd17985 |
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ... |
350-525 |
3.96e-45 |
|
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350743 [Multi-domain] Cd Length: 177 Bit Score: 160.78 E-value: 3.96e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 350 LPVFRCRSQLLSLIRENQVVVIIGETGSGKTTQLAQYLYEEGY--ANDRGKSIVVTQPRRVAAMSVAKRVAMEMQVPLGK 427
Cdd:cd17985 1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDNSLqgPPLPVANIICTQPRRISAISVAERVAQERAERVGQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 428 EVGYSVRFEDVTdSECTKLKFVTDGILLRETLLDDTLDKYSCVIIDEAHERSLNTDILLGFFKILLARRRDLKLIITSAT 507
Cdd:cd17985 81 SVGYQIRLESVK-SSATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPDLKVILMSAT 159
|
170
....*....|....*...
gi 767155161 508 MNAKKFSAFFGNAPQFTI 525
Cdd:cd17985 160 LNAELFSDYFNSCPVIHI 177
|
|
| DEXHc_DHX30 |
cd17976 |
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ... |
350-521 |
6.79e-45 |
|
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350734 [Multi-domain] Cd Length: 178 Bit Score: 159.96 E-value: 6.79e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 350 LPVFRCRSQLLSLIRENQVVVIIGETGSGKTTQLAQYLYEEGYANDRGK--SIVVTQPRRVAAMSVAKRVAMEMQVPLGK 427
Cdd:cd17976 1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEDYVLRGRGArcNVVITQPRRISAVSVAQRVAHELGPNLRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 428 EVGYSVRFEDVTDSECTKLKFVTDGILLRETLLDDTLDKYSCVIIDEAHERSLNTDILLGFFKILLARRRDLKLIITSAT 507
Cdd:cd17976 81 NVGYQVRLESRPPPRGGALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPELRVVLMSAT 160
|
170
....*....|....
gi 767155161 508 MNAKKFSAFFGNAP 521
Cdd:cd17976 161 GDNQRLSRYFGGCP 174
|
|
| DEXHc_DHX29 |
cd17975 |
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ... |
350-525 |
1.86e-44 |
|
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350733 [Multi-domain] Cd Length: 183 Bit Score: 158.92 E-value: 1.86e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 350 LPVFRCRSQLLSLIRENQVVVIIGETGSGKTTQLAQYLYEEGYAND---RGKSIVVTQPRRVAAMSVAKRVAMEMQV--- 423
Cdd:cd17975 1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEDLLLNGgtaQKCNIVCTQPRRISAMSLATRVCEELGCesg 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 424 PLGKE--VGYSVRFEDVTdSECTKLKFVTDGILLRETLLDDTLDKYSCVIIDEAHERSLNTDILLGFFKILLARRRDLKL 501
Cdd:cd17975 81 PGGKNslCGYQIRMESRT-GEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSDLHL 159
|
170 180
....*....|....*....|....
gi 767155161 502 IITSATMNAKKFSAFFGNAPQFTI 525
Cdd:cd17975 160 ILMSATVDCEKFSSYFTHCPILRI 183
|
|
| DEXHc_YTHDC2 |
cd17987 |
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ... |
350-521 |
2.53e-42 |
|
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350745 [Multi-domain] Cd Length: 176 Bit Score: 152.68 E-value: 2.53e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 350 LPVFRCRSQLLSLIRENQVVVIIGETGSGKTTQLAQYLYEEGYANDRGKSIVVTQPRRVAAMSVAKRVAMEMQVPLGKEV 429
Cdd:cd17987 1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDDCYANGIPCRIFCTQPRRLAAIAVAERVAAERGEKIGQTV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 430 GYSVRFEDVTdSECTKLKFVTDGILLReTLL--DDTLDKYSCVIIDEAHERSLNTDILLGFFKILLARRRDLKLIITSAT 507
Cdd:cd17987 81 GYQIRLESRV-SPKTLLTFCTNGVLLR-TLMagDSALSTVTHVIVDEVHERDRFSDFLLTKLRDILQKHPNLKLILSSAA 158
|
170
....*....|....
gi 767155161 508 MNAKKFSAFFGNAP 521
Cdd:cd17987 159 LDVNLFIRYFGSCP 172
|
|
| DEXHc_TDRD9 |
cd17988 |
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ... |
350-526 |
2.71e-41 |
|
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350746 [Multi-domain] Cd Length: 180 Bit Score: 149.96 E-value: 2.71e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 350 LPVFRCRSQLLSLIRENQVVVIIGETGSGKTTQLAQYLYEEGYANDRGKSIVVTQPRRVAAMSVAKRVAMEMQVPLGKEV 429
Cdd:cd17988 1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFILDHYYKRGKYCNIVVTQPRRIAAISIARRVSQEREWTLGSLV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 430 GYSVRFEDVTdSECTKLKFVTDGILLRETLLDDTLDKYSCVIIDEAHERSLNTDILLGFFKILLA-RRRDLKLIITSATM 508
Cdd:cd17988 81 GYQVGLERPA-SEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVVRRLLRtNSRHVKIILMSATI 159
|
170 180
....*....|....*....|
gi 767155161 509 NAKKFSAFFG--NAPQFTIP 526
Cdd:cd17988 160 SCKEFADYFTtpNNPAYVFE 179
|
|
| DEXHc_HrpB |
cd17990 |
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ... |
350-521 |
7.95e-41 |
|
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438711 [Multi-domain] Cd Length: 174 Bit Score: 148.25 E-value: 7.95e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 350 LPVFRCRSQLLSLIRENQVVVIIGETGSGKTT----QLAQYLYeegyanDRGKSIVVTQPRRVAAMSVAKRVAMEMQVPL 425
Cdd:cd17990 1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTrvplALLAELW------IAGGKIIVLEPRRVAARAAARRLATLLGEAP 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 426 GKEVGYSVRFEDVTdSECTKLKFVTDGILLRETLLDDTLDKYSCVIIDEAHERSLNTDILLGFF-KILLARRRDLKLIIT 504
Cdd:cd17990 75 GETVGYRVRGESRV-GRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLlEVQQLLRDDLRLLAM 153
|
170
....*....|....*..
gi 767155161 505 SATMNAKKFSAFFGNAP 521
Cdd:cd17990 154 SATLDGDGLAALLPEAP 170
|
|
| DEXHc_DHX32 |
cd17977 |
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ... |
350-522 |
1.32e-35 |
|
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350735 [Multi-domain] Cd Length: 176 Bit Score: 133.41 E-value: 1.32e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 350 LPVFRCRSQLLSLIRENQVVVIIGETGSGKTTQLAQYLYEEGYAND-RGKSIVVTQPRRVAAMSVAKRVAMEMQVPLGKE 428
Cdd:cd17977 1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQWCAEYCLSAHyQHGVVVCTQVHKQTAVWLALRVADEMDVNIGHE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 429 VGYSVRFEDVTDSEcTKLKFVTDGILLRETLLDDTLDKYSCVIIDEAHERSLNTDILLGFFKILLARRRDLKLIITSATM 508
Cdd:cd17977 81 VGYVIPFENCCTNE-TILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPELKLVIITCPH 159
|
170
....*....|....
gi 767155161 509 NAKKFSAFFGNAPQ 522
Cdd:cd17977 160 LSSKLLSYYGNVPL 173
|
|
| DEXQc_DQX1 |
cd17986 |
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ... |
350-521 |
1.01e-33 |
|
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350744 [Multi-domain] Cd Length: 177 Bit Score: 128.09 E-value: 1.01e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 350 LPVFRCRSQLLS-LIRENQVVVIIGETGSGKTTQLAQYLYEegYANDRG---KSIVVTQPRRVAAMSVAKRVAMEMQVPL 425
Cdd:cd17986 1 LPIWAAKFTFLEqLESPSGIVLVSGEPGSGKSTQVPQWCAE--FALSRGfqkGQVTVTQPHPLAARSLALRVADEMDLNL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 426 GKEVGYSVRFEDVTDSEcTKLKFVTDGILLRETLLDDTLDKYSCVIIDEAHERSLNTDILLGFFKILLARRRDLKLIITS 505
Cdd:cd17986 79 GHEVGYSIPQEDCTGPN-TILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQRPELRVVVVT 157
|
170
....*....|....*.
gi 767155161 506 ATMNAKKFSAFFGNAP 521
Cdd:cd17986 158 SPALEPKLRAFWGNPP 173
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
764-846 |
6.89e-29 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 110.44 E-value: 6.89e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 764 IGAIDTRGQLTPLGLQMAKFPLQPSLSKILLIAVRNGCSDEMLTIVSMLSVPQvfYRPKERQKEADIARNKFFIAKSDHL 843
Cdd:smart00847 2 LGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGD--PRPKEKREDADAARRRFADPESDHL 79
|
...
gi 767155161 844 TLL 846
Cdd:smart00847 80 TLL 82
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
757-845 |
7.28e-27 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 105.78 E-value: 7.28e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 757 SLYELWFIGAIDTRGQLTPLGLQMAKFPLQPSLSKILLIAVRNGCSDEMLTIVSMLSVPQVFYRP---KERQKEADIARN 833
Cdd:pfam04408 1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPnflDPRSAAKAARRR 80
|
90 100
....*....|....*....|....
gi 767155161 834 KFF------------IAKSDHLTL 845
Cdd:pfam04408 81 RRAadekarakfarlDLEGDHLTL 104
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
362-531 |
3.63e-25 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 104.11 E-value: 3.63e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 362 LIRENQVVVIIGETGSGKTTQLAQYLYEEGYANDRGKSIVVTqPRRVAAMSVAKRVAMEMQVPLGKEVGY-----SVRFE 436
Cdd:smart00487 20 LLSGLRDVILAAPTGSGKTLAALLPALEALKRGKGGRVLVLV-PTRELAEQWAEELKKLGPSLGLKVVGLyggdsKREQL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 437 DVTDSECTKLKFVTDGILLRETLLDDT-LDKYSCVIIDEAHERS--LNTDILLgffKILLARRRDLKLIITSATM--NAK 511
Cdd:smart00487 99 RKLESGKTDILVTTPGRLLDLLENDKLsLSNVDLVILDEAHRLLdgGFGDQLE---KLLKLLPKNVQLLLLSATPpeEIE 175
|
170 180
....*....|....*....|
gi 767155161 512 KFSAFFGNAPQFTIPGRTFP 531
Cdd:smart00487 176 NLLELFLNDPVFIDVGFTPL 195
|
|
| PHA02653 |
PHA02653 |
RNA helicase NPH-II; Provisional |
310-719 |
3.26e-20 |
|
RNA helicase NPH-II; Provisional
Pssm-ID: 177443 [Multi-domain] Cd Length: 675 Bit Score: 96.59 E-value: 3.26e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 310 GEVLGLENNNKAKDKSNQKICDDTALFTPSKDDIKHTKEQLPVFRcrsqllSLIReNQVVVIIGETGSGKTTQLAQ---- 385
Cdd:PHA02653 130 GNALGIFSNNVGSKKDTIGILGNPEPFSKIPLASLQPDVQLKIFE------AWIS-RKPVVLTGGTGVGKTSQVPKlllw 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 386 --YLYEeGY-------ANDRGKSIVVTQPRR--VAAMSVAKRVAMEMQVPLGKEVgySVRFEDVTDSEcTKLKFVTDGIL 454
Cdd:PHA02653 203 fnYLFG-GFdnldkidPNFIERPIVLSLPRValVRLHSITLLKSLGFDEIDGSPI--SLKYGSIPDEL-INTNPKPYGLV 278
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 455 L---RETLldDTLDKYSCVIIDEAHERSLNTDILLGFFKILLARRRDLKLIitSATM--NAKKFSAFFGNAPQFTIPGRT 529
Cdd:PHA02653 279 FsthKLTL--NKLFDYGTVIIDEVHEHDQIGDIIIAVARKHIDKIRSLFLM--TATLedDRDRIKEFFPNPAFVHIPGGT 354
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 530 -FPVQTIYTSNPVQ-----DYVEAA---VSQAVKIHLANDCSSGdiLIFMTGQEDIETTFDTLQEKF--LQVYSKKFGTA 598
Cdd:PHA02653 355 lFPISEVYVKNKYNpknkrAYIEEEkknIVTALKKYTPPKGSSG--IVFVASVSQCEEYKKYLEKRLpiYDFYIIHGKVP 432
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 599 NFEEindieilpiysalpadlqfkIFQDLHGTKR-KIIIATNIAETSLTIKGIRYVIDCGysklKVYNPK-IGLDslvIT 676
Cdd:PHA02653 433 NIDE--------------------ILEKVYSSKNpSIIISTPYLESSVTIRNATHVYDTG----RVYVPEpFGGK---EM 485
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 767155161 677 PISKANADQRSGRAGRTAPGTAYRLYTEDtfkedmYLQTIPEI 719
Cdd:PHA02653 486 FISKSMRTQRKGRVGRVSPGTYVYFYDLD------LLKPIKRI 522
|
|
| OB_NTP_bind |
pfam07717 |
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ... |
903-980 |
2.10e-19 |
|
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
Pssm-ID: 400182 [Multi-domain] Cd Length: 82 Bit Score: 83.46 E-value: 2.10e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 903 IKKCICSGFAHQ-AAKITGLRNYVHLKTGVSVQLHPTSALHGLGDLPP-YVVYHELLMTSKEYICCVTSVDPFWLMEYGG 980
Cdd:pfam07717 1 LRAALAAGLYPNvARRDPKGKGYTTLSDNQRVFIHPSSVLFNEKTFPPeWVVYQELVETTKVYIRTVTAISPEWLLLFAP 80
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
598-692 |
1.00e-13 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 67.24 E-value: 1.00e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 598 ANFEEINDIEILPIYSALPADLQFKIFQDLHGTKRKIIIATNIAETSLTIKGIRYVIDCGYsklkvynpkigldslvitP 677
Cdd:smart00490 4 AELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDL------------------P 65
|
90
....*....|....*
gi 767155161 678 ISKANADQRSGRAGR 692
Cdd:smart00490 66 WSPASYIQRIGRAGR 80
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
564-692 |
3.38e-11 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 61.07 E-value: 3.38e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 564 GDILIFMTGQEDIETTFdtlqekflqvyskkfgtanFEEINDIEILPIYSALPADLQFKIFQDLHGTKRKIIIATNIAET 643
Cdd:pfam00271 16 GKVLIFSQTKKTLEAEL-------------------LLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAER 76
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 767155161 644 SLTIKGIRYVIDCGYSklkvYNPkigldslvitpiskANADQRSGRAGR 692
Cdd:pfam00271 77 GLDLPDVDLVINYDLP----WNP--------------ASYIQRIGRAGR 107
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
369-507 |
6.71e-09 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 55.49 E-value: 6.71e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 369 VVIIGETGSGKTTQLAQYLYEEgyANDRGKSIVVTQPRRvaamSVAKRVAMEMQVPL--GKEVGYSVRFEDVTDSECTKL 446
Cdd:cd00046 4 VLITAPTGSGKTLAALLAALLL--LLKKGKKVLVLVPTK----ALALQTAERLRELFgpGIRVAVLVGGSSAEEREKNKL 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767155161 447 K-----FVTDGILLR--ETLLDDTLDKYSCVIIDEAHERSLNTD-ILLGFFKILLARRRDLKLIITSAT 507
Cdd:cd00046 78 GdadiiIATPDMLLNllLREDRLFLKDLKLIIVDEAHALLIDSRgALILDLAVRKAGLKNAQVILLSAT 146
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
360-509 |
4.90e-08 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 53.79 E-value: 4.90e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 360 LSLIRENQVVVIIGETGSGKTT--QLAqyLYEEGYANDRGKSIVVTQPRRVAAMSVAKRVamemqVPLGKEVGYSVRFE- 436
Cdd:pfam00270 8 IPAILEGRDVLVQAPTGSGKTLafLLP--ALEALDKLDNGPQALVLAPTRELAEQIYEEL-----KKLGKGLGLKVASLl 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 437 --DVTDSECTKLK-----FVTDGILLRETLLDDTLDKYSCVIIDEAHeRSLNTDILLGFFKILLARRRDLKLIITSATMN 509
Cdd:pfam00270 81 ggDSRKEQLEKLKgpdilVGTPGRLLDLLQERKLLKNLKLLVLDEAH-RLLDMGFGPDLEEILRRLPKKRQILLLSATLP 159
|
|
| AAA_22 |
pfam13401 |
AAA domain; |
367-503 |
3.64e-05 |
|
AAA domain;
Pssm-ID: 379165 [Multi-domain] Cd Length: 129 Bit Score: 44.25 E-value: 3.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 367 QVVVIIGETGSGKTTQLAQYLYEEGYANDRgkSIVVTQPRRVAAMSVAKRVAMEMQVPLGKEVGYSVRFEdvtdsectkl 446
Cdd:pfam13401 6 GILVLTGESGTGKTTLLRRLLEQLPEVRDS--VVFVDLPSGTSPKDLLRALLRALGLPLSGRLSKEELLA---------- 73
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 767155161 447 kfvtdgiLLRETLLDdtLDKYSCVIIDEAHERSLNtdiLLGFFKILL-ARRRDLKLII 503
Cdd:pfam13401 74 -------ALQQLLLA--LAVAVVLIIDEAQHLSLE---ALEELRDLLnLSSKLLQLIL 119
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
633-699 |
4.27e-05 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 42.69 E-value: 4.27e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767155161 633 KIIIATNIAETSLTIKGIRYVIDCGYsklkvynpkigldslvitPISKANADQRSGRAGRTAPGTAY 699
Cdd:cd18785 24 EILVATNVLGEGIDVPSLDTVIFFDP------------------PSSAASYIQRVGRAGRGGKDEGE 72
|
|
| DEXHc_viral_Ns3 |
cd17931 |
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional ... |
367-476 |
1.18e-04 |
|
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional protein found in pestiviruses that contains an N-terminal protease and a C-terminal helicase. The N-terminal domain is a chymotrypsin-like serine protease, which is responsible for most of the maturation cleavages of the polyprotein precursor in the cytosolic side of the endoplasmic reticulum membrane. The C-terminal domain, about two-thirds of NS3, is a helicase belonging to superfamily 2 (SF2) thought to be important for unwinding highly structured regions of the RNA genome during replication. NS3 plays an essential role in viral polyprotein processing and genome replication. NS3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350689 [Multi-domain] Cd Length: 151 Bit Score: 43.69 E-value: 1.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 367 QVVVIIGETGSGKTTQLAQYLYEEGYanDRGKSIVVTQPRRVAAMSVAKrvAMEmqvplGKEVGYSVRFEDVTDSECTKL 446
Cdd:cd17931 2 QLTVLDLHPGAGKTTRVLPQIIREAI--KKRLRTLVLAPTRVVAAEMYE--ALR-----GLPIRYRTGAVKEEHGGNEIV 72
|
90 100 110
....*....|....*....|....*....|
gi 767155161 447 KFVTDGILLRETLLDDTLDKYSCVIIDEAH 476
Cdd:cd17931 73 DYMCHGTFTCRLLSPKRVPNYNLIIMDEAH 102
|
|
| ExeA |
COG3267 |
Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, ... |
354-476 |
3.00e-04 |
|
Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];
Pssm-ID: 442498 [Multi-domain] Cd Length: 261 Bit Score: 43.62 E-value: 3.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 354 RCRSQLLSLIRENQ-VVVIIGETGSGKTTqLAQYLYEEgyANDRGKSIVVTQPrRVAAMSVAKRVAMEMQVPLgKEVGYS 432
Cdd:COG3267 30 EALARLEYALAQGGgFVVLTGEVGTGKTT-LLRRLLER--LPDDVKVAYIPNP-QLSPAELLRAIADELGLEP-KGASKA 104
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 767155161 433 VRFEDvtdsectklkfvtdgilLRETLLDDTLDKYSCV-IIDEAH 476
Cdd:COG3267 105 DLLRQ-----------------LQEFLLELAAAGRRVVlIIDEAQ 132
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
349-526 |
3.51e-03 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 39.55 E-value: 3.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 349 QLPVFRCrsqllsLIRENQVVVIIGETGSGKTTqLAQYLYEEGYANDRGKSIVVTqPRRvaamSVAKRVAMEMQ---VPL 425
Cdd:cd17921 6 QREALRA------LYLSGDSVLVSAPTSSGKTL-IAELAILRALATSGGKAVYIA-PTR----ALVNQKEADLRerfGPL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 426 GKEVG-----YSVRFEDVTDSE---CTKLKFvtDGILLRETllDDTLDKYSCVIIDEAH-----ERSLNTDILLGFfkiL 492
Cdd:cd17921 74 GKNVGlltgdPSVNKLLLAEADilvATPEKL--DLLLRNGG--ERLIQDVRLVVVDEAHligdgERGVVLELLLSR---L 146
|
170 180 190
....*....|....*....|....*....|....*
gi 767155161 493 LARRRDLKLIITSATM-NAKKFSAFFGNAPQFTIP 526
Cdd:cd17921 147 LRINKNARFVGLSATLpNAEDLAEWLGVEDLIRFD 181
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
362-476 |
9.72e-03 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 40.01 E-value: 9.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767155161 362 LIRENQVVVIIGETGSGKTTqLAQYLYEEgyANDRGKSIVVTqPRRVAAMSVAKRVAMEMQVPLGKEVGYSVRFeDVTds 441
Cdd:COG1061 96 LERGGGRGLVVAPTGTGKTV-LALALAAE--LLRGKRVLVLV-PRRELLEQWAEELRRFLGDPLAGGGKKDSDA-PIT-- 168
|
90 100 110
....*....|....*....|....*....|....*
gi 767155161 442 ectklkFVTDGILLRETLLDDTLDKYSCVIIDEAH 476
Cdd:COG1061 169 ------VATYQSLARRAHLDELGDRFGLVIIDEAH 197
|
|
| |
