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Conserved domains on  [gi|766917858|ref|XP_011495125|]
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PREDICTED: probable RNA methyltransferase CG11342 isoform X1 [Ceratosolen solmsi marchali]

Protein Classification

BCDIN3 domain-containing RNA methyltransferase( domain architecture ID 20705480)

BCDIN3 domain-containing RNA methyltransferase acts as O-methyltransferase that specifically monomethylates 5'-monophosphate of cytoplasmic histidyl tRNA (tRNA(His)), acting as a capping enzyme by protecting tRNA(His) from cleavage by DICER1

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008173|GO:0001510|GO:0008757|GO:1904047|GO:0008171|GO:0090486
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Bin3 super family cl47958
Bicoid-interacting protein 3 (Bin3); This family represents a conserved region of ...
 157-263 1.15e-16

Bicoid-interacting protein 3 (Bin3); This family represents a conserved region of approximately 120 residues within eukaryotic Bicoid-interacting protein 3 (Bin3). Bin3, which shows similarity to a number of protein methyltransferases that modify RNA-binding proteins, interacts with Bicoid, which itself directs pattern formation in the early Drosophila embryo. The interaction might allow Bicoid to switch between its dual roles in transcription and translation. Note that family members contain a conserved HLN motif.


The actual alignment was detected with superfamily member pfam06859:

Pssm-ID: 462022  Cd Length: 109  Bit Score: 73.73  E-value: 1.15e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766917858  157 FDASFCFSITMWIHLNKGDAGLELFLRDVCSCSE---VVLVEPQPWRCYRSAARRLRRanlgDFPLLEGLEYRDEvqrHI 233
Cdd:pfam06859   1 YDVILCLSVTKWIHLNWGDEGLKRFFKRIYSLLRpggVLILEPQPWKSYKKAKRLSET----IKANYKTIQLRPE---DF 73

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 766917858  234 EKILRDQCKFRRLHV------SEKNEWQRRLILYKR 263
Cdd:pfam06859  74 EEYLLSEVGFESVEElgstpeGKSKGFDRPIYLFRK 109
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 78-183 1.14e-08

Methyltransferase domain; This family appears to be a methyltransferase domain.


:

Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 51.41  E-value: 1.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766917858   78 LDIGCNTGDLTLELYKFLsknlperKISIIGIDLDPVLIERAQEKNDQFE-SVTFVCIDFFSNDRENvlssylserhkKR 156
Cdd:pfam13649   2 LDLGCGTGRLTLALARRG-------GARVTGVDLSPEMLERARERAAEAGlNVEFVQGDAEDLPFPD-----------GS 63

                          90       100
                  ....*....|....*....|....*..
gi 766917858  157 FDASFCFSITMWIHLNKGDAGLELFLR 183
Cdd:pfam13649  64 FDLVVSSGVLHHLPDPDLEAALREIAR 90
 
Name Accession Description Interval E-value
Bin3 pfam06859
Bicoid-interacting protein 3 (Bin3); This family represents a conserved region of ...
 157-263 1.15e-16

Bicoid-interacting protein 3 (Bin3); This family represents a conserved region of approximately 120 residues within eukaryotic Bicoid-interacting protein 3 (Bin3). Bin3, which shows similarity to a number of protein methyltransferases that modify RNA-binding proteins, interacts with Bicoid, which itself directs pattern formation in the early Drosophila embryo. The interaction might allow Bicoid to switch between its dual roles in transcription and translation. Note that family members contain a conserved HLN motif.


Pssm-ID: 462022  Cd Length: 109  Bit Score: 73.73  E-value: 1.15e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766917858  157 FDASFCFSITMWIHLNKGDAGLELFLRDVCSCSE---VVLVEPQPWRCYRSAARRLRRanlgDFPLLEGLEYRDEvqrHI 233
Cdd:pfam06859   1 YDVILCLSVTKWIHLNWGDEGLKRFFKRIYSLLRpggVLILEPQPWKSYKKAKRLSET----IKANYKTIQLRPE---DF 73

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 766917858  234 EKILRDQCKFRRLHV------SEKNEWQRRLILYKR 263
Cdd:pfam06859  74 EEYLLSEVGFESVEElgstpeGKSKGFDRPIYLFRK 109
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 78-183 1.14e-08

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 51.41  E-value: 1.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766917858   78 LDIGCNTGDLTLELYKFLsknlperKISIIGIDLDPVLIERAQEKNDQFE-SVTFVCIDFFSNDRENvlssylserhkKR 156
Cdd:pfam13649   2 LDLGCGTGRLTLALARRG-------GARVTGVDLSPEMLERARERAAEAGlNVEFVQGDAEDLPFPD-----------GS 63

                          90       100
                  ....*....|....*....|....*..
gi 766917858  157 FDASFCFSITMWIHLNKGDAGLELFLR 183
Cdd:pfam13649  64 FDLVVSSGVLHHLPDPDLEAALREIAR 90
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
77-136 2.44e-08

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 50.59  E-value: 2.44e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 766917858  77 ALDIGCNTGDLTLELykflSKNLPERkiSIIGIDLDPVLIERAQEKNDQfesVTFVCIDF 136
Cdd:COG4106    5 VLDLGCGTGRLTALL----AERFPGA--RVTGVDLSPEMLARARARLPN---VRFVVADL 55
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 77-259 3.36e-06

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 46.83  E-value: 3.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766917858  77 ALDIGCNTGDLTLELykflsknLPERKISIIGIDLDPVLIERAQEKNDQFE--SVTFVCIDFFSNDrenvlssylsERHK 154
Cdd:COG0500   30 VLDLGCGTGRNLLAL-------AARFGGRVIGIDLSPEAIALARARAAKAGlgNVEFLVADLAELD----------PLPA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766917858 155 KRFDASFCFSITMWIHLNKGDAGLElFLRDVCSCSEVVLVEPQPwrcyrsaarrlrrANLGDFPLLEGLEYRDEVQRHIE 234
Cdd:COG0500   93 ESFDLVVAFGVLHHLPPEEREALLR-ELARALKPGGVLLLSASD-------------AAAALSLARLLLLATASLLELLL 158

                        170       180
                 ....*....|....*....|....*
gi 766917858 235 KiLRDQCKFRRLHVSEKNEWQRRLI 259
Cdd:COG0500  159 L-LRLLALELYLRALLAAAATEDLR 182
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 78-137 3.41e-06

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 44.73  E-value: 3.41e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 766917858  78 LDIGCNTGDLTLELYKFLsknlperKISIIGIDLDPVLIERAQEKND--QFESVTFVCIDFF 137
Cdd:cd02440    3 LDLGCGTGALALALASGP-------GARVTGVDISPVALELARKAAAalLADNVEVLKGDAE 57
 
Name Accession Description Interval E-value
Bin3 pfam06859
Bicoid-interacting protein 3 (Bin3); This family represents a conserved region of ...
 157-263 1.15e-16

Bicoid-interacting protein 3 (Bin3); This family represents a conserved region of approximately 120 residues within eukaryotic Bicoid-interacting protein 3 (Bin3). Bin3, which shows similarity to a number of protein methyltransferases that modify RNA-binding proteins, interacts with Bicoid, which itself directs pattern formation in the early Drosophila embryo. The interaction might allow Bicoid to switch between its dual roles in transcription and translation. Note that family members contain a conserved HLN motif.


Pssm-ID: 462022  Cd Length: 109  Bit Score: 73.73  E-value: 1.15e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766917858  157 FDASFCFSITMWIHLNKGDAGLELFLRDVCSCSE---VVLVEPQPWRCYRSAARRLRRanlgDFPLLEGLEYRDEvqrHI 233
Cdd:pfam06859   1 YDVILCLSVTKWIHLNWGDEGLKRFFKRIYSLLRpggVLILEPQPWKSYKKAKRLSET----IKANYKTIQLRPE---DF 73

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 766917858  234 EKILRDQCKFRRLHV------SEKNEWQRRLILYKR 263
Cdd:pfam06859  74 EEYLLSEVGFESVEElgstpeGKSKGFDRPIYLFRK 109
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 78-183 1.14e-08

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 51.41  E-value: 1.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766917858   78 LDIGCNTGDLTLELYKFLsknlperKISIIGIDLDPVLIERAQEKNDQFE-SVTFVCIDFFSNDRENvlssylserhkKR 156
Cdd:pfam13649   2 LDLGCGTGRLTLALARRG-------GARVTGVDLSPEMLERARERAAEAGlNVEFVQGDAEDLPFPD-----------GS 63

                          90       100
                  ....*....|....*....|....*..
gi 766917858  157 FDASFCFSITMWIHLNKGDAGLELFLR 183
Cdd:pfam13649  64 FDLVVSSGVLHHLPDPDLEAALREIAR 90
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
77-136 2.44e-08

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 50.59  E-value: 2.44e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 766917858  77 ALDIGCNTGDLTLELykflSKNLPERkiSIIGIDLDPVLIERAQEKNDQfesVTFVCIDF 136
Cdd:COG4106    5 VLDLGCGTGRLTALL----AERFPGA--RVTGVDLSPEMLARARARLPN---VRFVVADL 55
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 62-136 5.43e-07

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 48.07  E-value: 5.43e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 766917858  62 PEAIYESAGPSPMFVALDIGCNTGDLTLELYkflsknlpERKISIIGIDLDPVLIERAQEKN-DQFESVTFVCIDF 136
Cdd:COG2226   11 REALLAALGLRPGARVLDLGCGTGRLALALA--------ERGARVTGVDISPEMLELARERAaEAGLNVEFVVGDA 78
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 78-164 6.04e-07

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 46.59  E-value: 6.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766917858   78 LDIGCNTGDLTlelyKFLSKNLPErkISIIGIDLDPVLIERAQEKNDQFESVTFVCIDFFSNDrenvlssyLSERHKKRF 157
Cdd:pfam08242   1 LEIGCGTGTLL----RALLEALPG--LEYTGLDISPAALEAARERLAALGLLNAVRVELFQLD--------LGELDPGSF 66


                  ....*..
gi 766917858  158 DASFCFS 164
Cdd:pfam08242  67 DVVVASN 73
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 77-136 7.48e-07

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 47.32  E-value: 7.48e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 766917858  77 ALDIGCNTGDLTLELYkflsknlpERKISIIGIDLDPVLIERAQEKNDQFeSVTFVCIDF 136
Cdd:COG2227   28 VLDVGCGTGRLALALA--------RRGADVTGVDISPEALEIARERAAEL-NVDFVQGDL 78
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 78-200 1.67e-06

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 46.64  E-value: 1.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766917858   78 LDIGCNTGDLTLELYKFLSKNlperkISIIGIDLDPVLIERAQEKNDQ--FESVTFVCIDFfsndrENVLSSYlserHKK 155
Cdd:pfam13847   8 LDLGCGTGHLSFELAEELGPN-----AEVVGIDISEEAIEKARENAQKlgFDNVEFEQGDI-----EELPELL----EDD 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 766917858  156 RFDASFCFSITMwiHLNKGDAGLELFLRDVCSCSEVVLVEPQPWR 200
Cdd:pfam13847  74 KFDVVISNCVLN--HIPDPDKVLQEILRVLKPGGRLIISDPDSLA 116
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
63-136 2.51e-06

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 46.92  E-value: 2.51e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 766917858  63 EAIYESAGPSPMFVALDIGCNTGdltlelykFLSKNLPERKISIIGIDLDPVLIERAQEKNDQfesVTFVCIDF 136
Cdd:COG4976   36 EELLARLPPGPFGRVLDLGCGTG--------LLGEALRPRGYRLTGVDLSEEMLAKAREKGVY---DRLLVADL 98
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 77-259 3.36e-06

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 46.83  E-value: 3.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766917858  77 ALDIGCNTGDLTLELykflsknLPERKISIIGIDLDPVLIERAQEKNDQFE--SVTFVCIDFFSNDrenvlssylsERHK 154
Cdd:COG0500   30 VLDLGCGTGRNLLAL-------AARFGGRVIGIDLSPEAIALARARAAKAGlgNVEFLVADLAELD----------PLPA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766917858 155 KRFDASFCFSITMWIHLNKGDAGLElFLRDVCSCSEVVLVEPQPwrcyrsaarrlrrANLGDFPLLEGLEYRDEVQRHIE 234
Cdd:COG0500   93 ESFDLVVAFGVLHHLPPEEREALLR-ELARALKPGGVLLLSASD-------------AAAALSLARLLLLATASLLELLL 158

                        170       180
                 ....*....|....*....|....*
gi 766917858 235 KiLRDQCKFRRLHVSEKNEWQRRLI 259
Cdd:COG0500  159 L-LRLLALELYLRALLAAAATEDLR 182
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 78-137 3.41e-06

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 44.73  E-value: 3.41e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 766917858  78 LDIGCNTGDLTLELYKFLsknlperKISIIGIDLDPVLIERAQEKND--QFESVTFVCIDFF 137
Cdd:cd02440    3 LDLGCGTGALALALASGP-------GARVTGVDISPVALELARKAAAalLADNVEVLKGDAE 57
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 52-188 4.72e-05

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 42.61  E-value: 4.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766917858  52 HPAEERMRqipEAIYESAGPSPMFVALDIGCNTGDLTLELYKflsknlpERKISIIGIDLDPVLIERAQEKNDQF---ES 128
Cdd:COG2230   33 EEAQEAKL---DLILRKLGLKPGMRVLDIGCGWGGLALYLAR-------RYGVRVTGVTLSPEQLEYARERAAEAglaDR 102

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 766917858 129 VTFVCIDffsndrenvlssYLSERHKKRFDAsfCFSITMWIHLnkGDAGLELFLRDVCSC 188
Cdd:COG2230  103 VEVRLAD------------YRDLPADGQFDA--IVSIGMFEHV--GPENYPAYFAKVARL 146
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 78-138 2.34e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 39.19  E-value: 2.34e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 766917858   78 LDIGCNTGdltlelykFLSKNLPERKISIIGIDLDPVLIERAQEKNdQFESVTFVCIDFFS 138
Cdd:pfam08241   1 LDVGCGTG--------LLTELLARLGARVTGVDISPEMLELAREKA-PREGLTFVVGDAED 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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