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Conserved domains on  [gi|7662236|ref|NP_055594|]
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TSC22 domain family protein 2 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ZIP_TSC22D2 cd21939
leucine zipper domain found in TSC22 domain family protein 2; TSC22 domain family protein 2 ...
693-755 1.04e-37

leucine zipper domain found in TSC22 domain family protein 2; TSC22 domain family protein 2 (TSC22D2), also called transforming growth factor beta-stimulated clone 22 domain family member 2, or TSC22-related-inducible leucine zipper protein 4 (TILZ4), may participate in the regulation of cell growth. It interacts with pyruvate kinase isoform M2 (PKM2) and WD repeat domain 77 (WDR77). The model corresponds to the conserved leucine zipper (ZIP) domain located at the C-terminus of TSC22D2. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.


:

Pssm-ID: 409279  Cd Length: 63  Bit Score: 134.71  E-value: 1.04e-37
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7662236  693 AMDLVKSHLMYAVREEVEVLKEQIKELVERNSLLERENALLKSLSSNDQLSQLPTQQANPGST 755
Cdd:cd21939   1 AMDLVKSHLMYAVREEVEVLKEQIKELIERNSLLERENALLKSLSNNDQLSQLSTQQGNPSST 63
PHA03247 super family cl33720
large tegument protein UL36; Provisional
138-642 1.22e-11

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 68.81  E-value: 1.22e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    138 QLAGSSAGPVTAAPSQPPTTCSSRFRVIKLDHGSGEPYRRgRWTCMEYYERDSDSSVLTRSGDCIRHSSTFDQTaeRDSG 217
Cdd:PHA03247 2611 PAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPE-RPRDDPAPGRVSRPRRARRLGRAAQASSPPQRP--RRRA 2687
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    218 LGATGGSVVVVVASMQGAHGPESGTDSSLTAVSQLPPSEKMSQPTPAQPqsfsvGQPQPPPPPVGGAVAQSSAPLPPFPG 297
Cdd:PHA03247 2688 ARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALP-----AAPAPPAVPAGPATPGGPARPARPPT 2762
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    298 AATGPQPMMAAAQPSQPQGAGPGGQTLPPTNVTLAQPAMSLPPQPGPAVGAPAAQQPQQFAYPQPQIPPGHLLPVQPSGQ 377
Cdd:PHA03247 2763 TAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPP 2842
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    378 SEYLQQHVAGLQPPSPAQPSSTGAAASPATAAtlPVGTGQNASSVGAQLMGASSQPSEAMAPRTGPAQGGQVAPCQPTGV 457
Cdd:PHA03247 2843 PGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAK--PAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQ 2920
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    458 PPATVGGVVQPCLGPAGAGQPQSVPPPQMGGSGPLSAVPGGPH--AVVPG---VPNVPAAVPAPSV--PSVSTTSVTMPN 530
Cdd:PHA03247 2921 PQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWlgALVPGrvaVPRFRVPQPAPSReaPASSTPPLTGHS 3000
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    531 VPAPLAQSQQLSSHT-PVSRSSSIIQHVGLPlAPGTHSAPTSLPQSDLSQFQTQTqplvgqvddtrrkSEPLPQPPLSLI 609
Cdd:PHA03247 3001 LSRVSSWASSLALHEeTDPPPVSLKQTLWPP-DDTEDSDADSLFDSDSERSDLEA-------------LDPLPPEPHDPF 3066
                         490       500       510
                  ....*....|....*....|....*....|....
gi 7662236    610 AeNKPVVKPPVADSLANP-LQLTPMNSLATSVFS 642
Cdd:PHA03247 3067 A-HEPDPATPEAGARESPsSQFGPPPLSANAALS 3099
 
Name Accession Description Interval E-value
ZIP_TSC22D2 cd21939
leucine zipper domain found in TSC22 domain family protein 2; TSC22 domain family protein 2 ...
693-755 1.04e-37

leucine zipper domain found in TSC22 domain family protein 2; TSC22 domain family protein 2 (TSC22D2), also called transforming growth factor beta-stimulated clone 22 domain family member 2, or TSC22-related-inducible leucine zipper protein 4 (TILZ4), may participate in the regulation of cell growth. It interacts with pyruvate kinase isoform M2 (PKM2) and WD repeat domain 77 (WDR77). The model corresponds to the conserved leucine zipper (ZIP) domain located at the C-terminus of TSC22D2. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.


Pssm-ID: 409279  Cd Length: 63  Bit Score: 134.71  E-value: 1.04e-37
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7662236  693 AMDLVKSHLMYAVREEVEVLKEQIKELVERNSLLERENALLKSLSSNDQLSQLPTQQANPGST 755
Cdd:cd21939   1 AMDLVKSHLMYAVREEVEVLKEQIKELIERNSLLERENALLKSLSNNDQLSQLSTQQGNPSST 63
TSC22 pfam01166
TSC-22/dip/bun family;
694-750 1.42e-29

TSC-22/dip/bun family;


Pssm-ID: 460093  Cd Length: 57  Bit Score: 111.25  E-value: 1.42e-29
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 7662236    694 MDLVKSHLMYAVREEVEVLKEQIKELVERNSLLERENALLKSLSSNDQLSQLPTQQA 750
Cdd:pfam01166   1 MDLVKSHLMYAVREEVEVLKEQIKELEERNSQLEEENSILRANASPEQLEQLSSQLQ 57
PHA03247 PHA03247
large tegument protein UL36; Provisional
138-642 1.22e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 68.81  E-value: 1.22e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    138 QLAGSSAGPVTAAPSQPPTTCSSRFRVIKLDHGSGEPYRRgRWTCMEYYERDSDSSVLTRSGDCIRHSSTFDQTaeRDSG 217
Cdd:PHA03247 2611 PAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPE-RPRDDPAPGRVSRPRRARRLGRAAQASSPPQRP--RRRA 2687
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    218 LGATGGSVVVVVASMQGAHGPESGTDSSLTAVSQLPPSEKMSQPTPAQPqsfsvGQPQPPPPPVGGAVAQSSAPLPPFPG 297
Cdd:PHA03247 2688 ARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALP-----AAPAPPAVPAGPATPGGPARPARPPT 2762
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    298 AATGPQPMMAAAQPSQPQGAGPGGQTLPPTNVTLAQPAMSLPPQPGPAVGAPAAQQPQQFAYPQPQIPPGHLLPVQPSGQ 377
Cdd:PHA03247 2763 TAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPP 2842
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    378 SEYLQQHVAGLQPPSPAQPSSTGAAASPATAAtlPVGTGQNASSVGAQLMGASSQPSEAMAPRTGPAQGGQVAPCQPTGV 457
Cdd:PHA03247 2843 PGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAK--PAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQ 2920
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    458 PPATVGGVVQPCLGPAGAGQPQSVPPPQMGGSGPLSAVPGGPH--AVVPG---VPNVPAAVPAPSV--PSVSTTSVTMPN 530
Cdd:PHA03247 2921 PQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWlgALVPGrvaVPRFRVPQPAPSReaPASSTPPLTGHS 3000
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    531 VPAPLAQSQQLSSHT-PVSRSSSIIQHVGLPlAPGTHSAPTSLPQSDLSQFQTQTqplvgqvddtrrkSEPLPQPPLSLI 609
Cdd:PHA03247 3001 LSRVSSWASSLALHEeTDPPPVSLKQTLWPP-DDTEDSDADSLFDSDSERSDLEA-------------LDPLPPEPHDPF 3066
                         490       500       510
                  ....*....|....*....|....*....|....
gi 7662236    610 AeNKPVVKPPVADSLANP-LQLTPMNSLATSVFS 642
Cdd:PHA03247 3067 A-HEPDPATPEAGARESPsSQFGPPPLSANAALS 3099
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
222-596 2.15e-09

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 61.18  E-value: 2.15e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    222 GGSVVVVVASMQGAHGPESGTDSSLTAVSQLPPsekMSQPTPAQPQSFSVGQPQPPPPPVGGAVAQSSAPLPPfpGAATG 301
Cdd:pfam09606  65 GGQGNGGMGGGQQGMPDPINALQNLAGQGTRPQ---MMGPMGPGPGGPMGQQMGGPGTASNLLASLGRPQMPM--GGAGF 139
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    302 PQPMMAAaqpsqpQGAGPGGQTLPPTNVTLAQPAMSLPPQPGPAVGAPAAQ----QPQQFAYPQPQIP-----PGHLLPV 372
Cdd:pfam09606 140 PSQMSRV------GRMQPGGQAGGMMQPSSGQPGSGTPNQMGPNGGPGQGQaggmNGGQQGPMGGQMPpqmgvPGMPGPA 213
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    373 QPSGQSEYLQQHVAGLQPPSPAQPSSTGAAASPATAAtlpvGTGQNASSVGAQLMGASSQPSEAMAPRTGPAQGGQVAPC 452
Cdd:pfam09606 214 DAGAQMGQQAQANGGMNPQQMGGAPNQVAMQQQQPQQ----QGQQSQLGMGINQMQQMPQGVGGGAGQGGPGQPMGPPGQ 289
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    453 QPTGVPPATVGGV--------VQPCLGPAGAGQPQSVPPPQMGGSGPLSAVPGGPHAVVPGVPNVPAAVPAPSVPSVSTT 524
Cdd:pfam09606 290 QPGAMPNVMSIGDqnnyqqqqTRQQQQQQGGNHPAAHQQQMNQSVGQGGQVVALGGLNHLETWNPGNFGGLGANPMQRGQ 369
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7662236    525 SVTMPNvPAPLAQSQQLSSHTPVSRSSSIIQHVGLPLAPGTHSAPTSLPQSDLS-QFQTQTQPLVGQVDDTRR 596
Cdd:pfam09606 370 PGMMSS-PSPVPGQQVRQVTPNQFMRQSPQPSVPSPQGPGSQPPQSHPGGMIPSpALIPSPSPQMSQQPAQQR 441
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
296-378 1.04e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 42.49  E-value: 1.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    296 PGAATGPQPMMAAAQPSQPQGAGPGGQTLPPTNVTL---------AQPAMSLPPQPGPAVGAPAAQQPQQFAYPQPQIPP 366
Cdd:TIGR01628 405 PQQQFNGQPLGWPRMSMMPTPMGPGGPLRPNGLAPMnavrapsrnAQNAAQKPPMQPVMYPPNYQSLPLSQDLPQPQSTA 484
                          90
                  ....*....|..
gi 7662236    367 GHLLPVQPSGQS 378
Cdd:TIGR01628 485 SQGGQNKKLAQV 496
PRK13169 PRK13169
DNA replication initiation control protein YabA;
707-759 2.77e-03

DNA replication initiation control protein YabA;


Pssm-ID: 183876  Cd Length: 110  Bit Score: 38.30  E-value: 2.77e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 7662236   707 EEVEVLKEQIKELVERNSLLERENALLKslssnDQLSQLpTQQANPGSTSQQQ 759
Cdd:PRK13169  22 KELGALKKQLAELLEENTALRLENDKLR-----ERLEEL-EAEEPAKEKKKKE 68
 
Name Accession Description Interval E-value
ZIP_TSC22D2 cd21939
leucine zipper domain found in TSC22 domain family protein 2; TSC22 domain family protein 2 ...
693-755 1.04e-37

leucine zipper domain found in TSC22 domain family protein 2; TSC22 domain family protein 2 (TSC22D2), also called transforming growth factor beta-stimulated clone 22 domain family member 2, or TSC22-related-inducible leucine zipper protein 4 (TILZ4), may participate in the regulation of cell growth. It interacts with pyruvate kinase isoform M2 (PKM2) and WD repeat domain 77 (WDR77). The model corresponds to the conserved leucine zipper (ZIP) domain located at the C-terminus of TSC22D2. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.


Pssm-ID: 409279  Cd Length: 63  Bit Score: 134.71  E-value: 1.04e-37
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7662236  693 AMDLVKSHLMYAVREEVEVLKEQIKELVERNSLLERENALLKSLSSNDQLSQLPTQQANPGST 755
Cdd:cd21939   1 AMDLVKSHLMYAVREEVEVLKEQIKELIERNSLLERENALLKSLSNNDQLSQLSTQQGNPSST 63
TSC22 pfam01166
TSC-22/dip/bun family;
694-750 1.42e-29

TSC-22/dip/bun family;


Pssm-ID: 460093  Cd Length: 57  Bit Score: 111.25  E-value: 1.42e-29
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 7662236    694 MDLVKSHLMYAVREEVEVLKEQIKELVERNSLLERENALLKSLSSNDQLSQLPTQQA 750
Cdd:pfam01166   1 MDLVKSHLMYAVREEVEVLKEQIKELEERNSQLEEENSILRANASPEQLEQLSSQLQ 57
ZIP_TSC22D4 cd21941
leucine zipper domain found in TSC22 domain family protein 4; TSC22 domain family protein 4 ...
684-749 1.61e-29

leucine zipper domain found in TSC22 domain family protein 4; TSC22 domain family protein 4 (TSC22D4), also called TSC22-related-inducible leucine zipper protein 2 (TILZ2), or Tsc-22-like protein THG-1, is a transcriptional repressor that acts as a molecular determinant of insulin signalling and glucose handling. It also functions in hepatic lipid handling by regulating hepatic very-low-density-lipoprotein (VLDL) release and lipogenic gene expression. This model corresponds to the conserved leucine zipper (ZIP) domain located at the C-terminus of TSC22D4. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.


Pssm-ID: 409281  Cd Length: 74  Bit Score: 111.57  E-value: 1.61e-29
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 7662236  684 VAIDNKIEQAMDLVKSHLMYAVREEVEVLKEQIKELVERNSLLERENALLKSLSSNDQLSQLPTQQ 749
Cdd:cd21941   1 VAIDNKIEQAMDLVKSHLLFAVREEVEVLKEQIKELSERNAALEQENSLLRSLATPQQLSRLQSRQ 66
ZIP_TSC22D cd21936
leucine zipper domain found in the TSC22 domain family of leucine zipper transcription factors; ...
693-741 5.80e-27

leucine zipper domain found in the TSC22 domain family of leucine zipper transcription factors; The TGF-beta-stimulated clone-22 domain (TSC22D) family includes TSC22D1-4 and similar proteins. They have diverse physiological functions, including cell growth, development, homeostasis, and immune regulation. All family members contain a conserved leucine zipper (ZIP) domain located at the C-terminus. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. In the bZIP family of transcription factors, the leucine zipper acts as a dimerization domain and the upstream basic region as a DNA-binding domain. However, DNA-binding capability of TSC22D family proteins is not obvious, due to the lack of the basic region found in the original bZIP DNA-binding domains. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.


Pssm-ID: 409276  Cd Length: 49  Bit Score: 103.41  E-value: 5.80e-27
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 7662236  693 AMDLVKSHLMYAVREEVEVLKEQIKELVERNSLLERENALLKSLSSNDQ 741
Cdd:cd21936   1 AMDLVKSHLMFAVREEVDVLKEQIAELEERISQLERENSLLRSNAPPEV 49
ZIP_TSC22D1 cd21938
leucine zipper domain found in TSC22 domain family protein 1; TSC22 domain family protein 1 ...
689-759 4.52e-25

leucine zipper domain found in TSC22 domain family protein 1; TSC22 domain family protein 1 (TSC22D1) is also called cerebral protein 2, regulatory protein TSC-22, TGFB-stimulated clone 22, or transforming growth factor beta-1-induced transcript 4 protein (TGFB1I4). It is a transcriptional repressor that was reported to be present in both the cytoplasmic and the nuclear fraction. It is activated by transcription growth factor-beta1 and other growth factors of osteoblastic cells. TSC22D1 acts on the C-type natriuretic peptide (CNP) promoter. It enhances c-Myc-mediated activation of the telomerase reverse transcriptase (TERT) promoter. This model corresponds to the conserved leucine zipper (ZIP) domain located at the C-terminus of TSC22D1. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.


Pssm-ID: 409278  Cd Length: 79  Bit Score: 99.06  E-value: 4.52e-25
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7662236  689 KIEQAMDLVKSHLMYAVREEVEVLKEQIKELVERNSLLERENALLKSLSSNDQLSQLPT--QQANPGSTSQQQ 759
Cdd:cd21938   1 KIEQAMDLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNLLKTLASPEQLAQFQAqlQTGSPPSSSQPP 73
ZIP_TSC22D3 cd21940
leucine zipper domain found in TSC22 domain family protein 3; TSC22 domain family protein 3 ...
693-752 1.37e-23

leucine zipper domain found in TSC22 domain family protein 3; TSC22 domain family protein 3 (TSC22D3) is also called DSIP-immunoreactive peptide, protein DIP, delta sleep-inducing peptide immunoreactor, glucocorticoid-induced leucine zipper protein (GILZ), TSC-22-like protein, or TSC-22-related protein (TSC-22R). It protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, it plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, it inhibits anti-CD3-induced NFKB1 nuclear translocation. TSC22D3 contains a leucine zipper motif, a Pro/Glu rich domain, and three potential phosphorylation sites. This model corresponds to the leucine zipper (ZIP) domain. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.


Pssm-ID: 409280  Cd Length: 81  Bit Score: 95.02  E-value: 1.37e-23
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 7662236  693 AMDLVKSHLMYAVREEVEVLKEQIKELVERNSLLERENALLKSLSSNDQL----SQLPTQQANP 752
Cdd:cd21940   1 AMDLVKNHLMYAVREEVEVLKEQIKELVEKNSQLERENSLLKTLASPEQLekfqSRLPSEETAP 64
ZIP_TSC22D-like cd21927
leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding ...
694-741 7.48e-18

leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins; The family includes TGF-beta-stimulated clone-22 domain (TSC22D) leucine zipper transcription factors, TSC22D1-4, as well as c-Myc-binding protein (MycBP). TSC22D proteins have diverse physiological functions, including cell growth, development, homeostasis, and immune regulation. MycBP, also called associate of Myc 1 (AMY-1), is a novel c-Myc binding protein that may control the transcriptional activity of Myc. It stimulates the activation of E box-dependent transcription by Myc. Members of this family contain a conserved leucine zipper (ZIP) domain. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. In the bZIP family of transcription factors, the leucine zipper acts as a dimerization domain and the upstream basic region as a DNA-binding domain. However, DNA-binding capability of TSC22D family proteins is not obvious, due to the lack of the basic region found in the original bZIP DNA-binding domains. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.


Pssm-ID: 409275  Cd Length: 51  Bit Score: 77.94  E-value: 7.48e-18
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 7662236  694 MDLVKSHLMYAVREE--VEVLKEQIKELVERNSLLERENALLKSLSSNDQ 741
Cdd:cd21927   2 LDFLKHHLGAATPENpeIELLRLELAEMKEKYEAIVEENKKLKAKLAQYE 51
PHA03247 PHA03247
large tegument protein UL36; Provisional
138-642 1.22e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 68.81  E-value: 1.22e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    138 QLAGSSAGPVTAAPSQPPTTCSSRFRVIKLDHGSGEPYRRgRWTCMEYYERDSDSSVLTRSGDCIRHSSTFDQTaeRDSG 217
Cdd:PHA03247 2611 PAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPE-RPRDDPAPGRVSRPRRARRLGRAAQASSPPQRP--RRRA 2687
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    218 LGATGGSVVVVVASMQGAHGPESGTDSSLTAVSQLPPSEKMSQPTPAQPqsfsvGQPQPPPPPVGGAVAQSSAPLPPFPG 297
Cdd:PHA03247 2688 ARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALP-----AAPAPPAVPAGPATPGGPARPARPPT 2762
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    298 AATGPQPMMAAAQPSQPQGAGPGGQTLPPTNVTLAQPAMSLPPQPGPAVGAPAAQQPQQFAYPQPQIPPGHLLPVQPSGQ 377
Cdd:PHA03247 2763 TAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPP 2842
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    378 SEYLQQHVAGLQPPSPAQPSSTGAAASPATAAtlPVGTGQNASSVGAQLMGASSQPSEAMAPRTGPAQGGQVAPCQPTGV 457
Cdd:PHA03247 2843 PGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAK--PAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQ 2920
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    458 PPATVGGVVQPCLGPAGAGQPQSVPPPQMGGSGPLSAVPGGPH--AVVPG---VPNVPAAVPAPSV--PSVSTTSVTMPN 530
Cdd:PHA03247 2921 PQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWlgALVPGrvaVPRFRVPQPAPSReaPASSTPPLTGHS 3000
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    531 VPAPLAQSQQLSSHT-PVSRSSSIIQHVGLPlAPGTHSAPTSLPQSDLSQFQTQTqplvgqvddtrrkSEPLPQPPLSLI 609
Cdd:PHA03247 3001 LSRVSSWASSLALHEeTDPPPVSLKQTLWPP-DDTEDSDADSLFDSDSERSDLEA-------------LDPLPPEPHDPF 3066
                         490       500       510
                  ....*....|....*....|....*....|....
gi 7662236    610 AeNKPVVKPPVADSLANP-LQLTPMNSLATSVFS 642
Cdd:PHA03247 3067 A-HEPDPATPEAGARESPsSQFGPPPLSANAALS 3099
PHA03247 PHA03247
large tegument protein UL36; Provisional
290-619 1.30e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 62.26  E-value: 1.30e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    290 APLPPFPGAATGPQPMMAAAQPSQPQGAGPGGQTLPPTNVTLAQPAMSLPPQPGPAVGAPAAQQPQQFAYPQPQIPPGHL 369
Cdd:PHA03247 2574 APRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPR 2653
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    370 LPVQPSGQSeylqQHVAGLQPPSPAQPSSTGAAASPATAATlPVGTGQNASSVGAQLMGASSQP---SEAMAPRTGPAQG 446
Cdd:PHA03247 2654 DDPAPGRVS----RPRRARRLGRAAQASSPPQRPRRRAARP-TVGSLTSLADPPPPPPTPEPAPhalVSATPLPPGPAAA 2728
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    447 GQVAPCQP-TGVPPATVGGVVQPClGPAGAGQPQSVPPPQmgGSGPLSAVPGGPHAVVPGVPNVPAAVPAPSVPSVSTTS 525
Cdd:PHA03247 2729 RQASPALPaAPAPPAVPAGPATPG-GPARPARPPTTAGPP--APAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPA 2805
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    526 VTMPNVPAPLAQSQQLSSHTPVSRSSSIIQHVGLPLAPGTHSAPTSL-----PQSDLSQFQTQTQPLVGQVDDTRRKSEP 600
Cdd:PHA03247 2806 DPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLggsvaPGGDVRRRPPSRSPAAKPAAPARPPVRR 2885
                         330
                  ....*....|....*....
gi 7662236    601 LPQPPLSLIAENKPVVKPP 619
Cdd:PHA03247 2886 LARPAVSRSTESFALPPDQ 2904
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
222-596 2.15e-09

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 61.18  E-value: 2.15e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    222 GGSVVVVVASMQGAHGPESGTDSSLTAVSQLPPsekMSQPTPAQPQSFSVGQPQPPPPPVGGAVAQSSAPLPPfpGAATG 301
Cdd:pfam09606  65 GGQGNGGMGGGQQGMPDPINALQNLAGQGTRPQ---MMGPMGPGPGGPMGQQMGGPGTASNLLASLGRPQMPM--GGAGF 139
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    302 PQPMMAAaqpsqpQGAGPGGQTLPPTNVTLAQPAMSLPPQPGPAVGAPAAQ----QPQQFAYPQPQIP-----PGHLLPV 372
Cdd:pfam09606 140 PSQMSRV------GRMQPGGQAGGMMQPSSGQPGSGTPNQMGPNGGPGQGQaggmNGGQQGPMGGQMPpqmgvPGMPGPA 213
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    373 QPSGQSEYLQQHVAGLQPPSPAQPSSTGAAASPATAAtlpvGTGQNASSVGAQLMGASSQPSEAMAPRTGPAQGGQVAPC 452
Cdd:pfam09606 214 DAGAQMGQQAQANGGMNPQQMGGAPNQVAMQQQQPQQ----QGQQSQLGMGINQMQQMPQGVGGGAGQGGPGQPMGPPGQ 289
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    453 QPTGVPPATVGGV--------VQPCLGPAGAGQPQSVPPPQMGGSGPLSAVPGGPHAVVPGVPNVPAAVPAPSVPSVSTT 524
Cdd:pfam09606 290 QPGAMPNVMSIGDqnnyqqqqTRQQQQQQGGNHPAAHQQQMNQSVGQGGQVVALGGLNHLETWNPGNFGGLGANPMQRGQ 369
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7662236    525 SVTMPNvPAPLAQSQQLSSHTPVSRSSSIIQHVGLPLAPGTHSAPTSLPQSDLS-QFQTQTQPLVGQVDDTRR 596
Cdd:pfam09606 370 PGMMSS-PSPVPGQQVRQVTPNQFMRQSPQPSVPSPQGPGSQPPQSHPGGMIPSpALIPSPSPQMSQQPAQQR 441
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
239-586 5.82e-09

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 59.78  E-value: 5.82e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    239 ESGTDSSLTA--VSQLPPSEKMSQPTPAQPQsfsvgqpqppppPVGGAVAQSSAPLPPFPGAATGPQPMMAAAQPSQPQG 316
Cdd:pfam03154 155 ESDSDSSAQQqiLQTQPPVLQAQSGAASPPS------------PPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQ 222
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    317 AGPGGQTLPPTNVTLAQPAMslpPQPGPAVGAPAAQQPQQFAYPQPQIPPGHLLPVQPSGQSeyLQQHVAGLQPPSPAQP 396
Cdd:pfam03154 223 STAAPHTLIQQTPTLHPQRL---PSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHS--LQTGPSHMQHPVPPQP 297
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    397 SSTGAAASPATAATLPVGTGQNASSVGAQLMGASSQPSEAMAPRTGPAQGGQVA-------PCQPTGVPPATVGGVVQPC 469
Cdd:pfam03154 298 FPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSmphikppPTTPIPQLPNPQSHKHPPH 377
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    470 L-GPAGAGQPQSVPPPQmgGSGPLSAVPGG--PHAVVPGVPNVPAAVPAPSVPSVSTTSVTMPNVPAPLAQSQQLSSHTP 546
Cdd:pfam03154 378 LsGPSPFQMNSNLPPPP--ALKPLSSLSTHhpPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQ 455
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 7662236    547 VSRSSSIIQHVGLPLAPGTHSAPTSLPQSDLSQFQTQTQP 586
Cdd:pfam03154 456 VPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPP 495
PHA03247 PHA03247
large tegument protein UL36; Provisional
249-625 5.57e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 56.87  E-value: 5.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    249 VSQLPPSEKMSQPTPAQPQSFSVGQPQppPPPVGGAVAQSSAPLPPFPGAATGPQPMMAAAQPSQPQGAGPGGQTLPPTN 328
Cdd:PHA03247 2479 VYRRPAEARFPFAAGAAPDPGGGGPPD--PDAPPAPSRLAPAILPDEPVGEPVHPRMLTWIRGLEELASDDAGDPPPPLP 2556
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    329 VTLAQPAMSL---PPQPGPAVGAPAAQQPQQfaypQPQIPPGHLLPVQPSGQSEylqqHVAGLQPPSPAQPSSTGAAASP 405
Cdd:PHA03247 2557 PAAPPAAPDRsvpPPRPAPRPSEPAVTSRAR----RPDAPPQSARPRAPVDDRG----DPRGPAPPSPLPPDTHAPDPPP 2628
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    406 ATAATLP--VGTGQNASSVGAQLMGASSQPSEAMAPRTGPAQGGQVAPCQPTGVP-----PATVGGVVQPCLGPAGAGQP 478
Cdd:PHA03247 2629 PSPSPAAnePDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPrrraaRPTVGSLTSLADPPPPPPTP 2708
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    479 QSVPPPQMGGSgPLSAVPGGPHAVVPGVPNVPAAVPAPSVPSVSTTSVTMPNVPAPLAQSQQLSSHTPVSR-SSSIIQHV 557
Cdd:PHA03247 2709 EPAPHALVSAT-PLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGpPRRLTRPA 2787
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 7662236    558 GLPLAPGTHSAPTSlpqSDLSQFQTQTQPLVGQVDDTRRKSEPLPqPPLSLIAENKPVVKPPVADSLA 625
Cdd:PHA03247 2788 VASLSESRESLPSP---WDPADPPAAVLAPAAALPPAASPAGPLP-PPTSAQPTAPPPPPGPPPPSLP 2851
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
213-605 1.75e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 51.53  E-value: 1.75e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   213 ERDSGLGATGGSVVVVVASMQGAHGPESGTDSSLTAVSQLPPSEKMSQPTPAQPQSFSVGQPQPPPPPVGGAVAQSSAPL 292
Cdd:PRK07764 382 ERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAA 461
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   293 PPFPGAATGPQPMMAAAQPSQPQGAGPGGQTLPPTnvtlaqpamslPPQPGPAVGAPAAQQPQQfAYPQ-----PQI--- 364
Cdd:PRK07764 462 PSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAA-----------PAAPAAPAGADDAATLRE-RWPEilaavPKRsrk 529
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   365 ------PPGHLLPVQpsGQSEYLQQHVAGLQPPSPAQPSSTGAAASPATAATLPV-------GTGQNASSVGAQLMGASS 431
Cdd:PRK07764 530 twaillPEATVLGVR--GDTLVLGFSTGGLARRFASPGNAEVLVTALAEELGGDWqveavvgPAPGAAGGEGPPAPASSG 607
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   432 QPSEAMAPRTGPAQGGQVAPCQPTGVPPATVGGVVQPCLGPAGAGQPQSVPPPQMGGSGPLSAVPGGPHAVV-PGVPNVP 510
Cdd:PRK07764 608 PPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAaPPPAPAP 687
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   511 AAVPAPSVPSVSTTSVTMPNVPAPLAQSQQLSSHTPVSRSSSIIQHVGLPLAPgTHSAPTSLPQSDLSQFQTQTQPLVGQ 590
Cdd:PRK07764 688 AAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVP-LPPEPDDPPDPAGAPAQPPPPPAPAP 766
                        410
                 ....*....|....*
gi 7662236   591 VDDTRRKSEPLPQPP 605
Cdd:PRK07764 767 AAAPAAAPPPSPPSE 781
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
317-522 2.76e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 51.14  E-value: 2.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   317 AGPGGQTLPPTNVTLAQPAMSLPPQPGPAVGAPAAQQPQQFAYPQPQIP-PGHLLPVQPSGQSEYLQQHVAGLQPPSPAQ 395
Cdd:PRK07764 588 VGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPaEASAAPAPGVAAPEHHPKHVAVPDASDGGD 667
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   396 PSSTGAAASPataatlPVGTGQNASSVGAQLMGASSQPSEAMAPRTGPAQGGQVAPCQPTGVPPATVGGVVQpclGPAGA 475
Cdd:PRK07764 668 GWPAKAGGAA------PAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSP---AADDP 738
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 7662236   476 GQPQSVPPPQMGGSGPLSAVPGGPHAVVPGVPNVPAAVPAPSVPSVS 522
Cdd:PRK07764 739 VPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEM 785
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
306-603 4.23e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 50.26  E-value: 4.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   306 MAAAQPSQpqgagPGGQTLPPTnvtlaqPAMSLPPQPGPAVGAPAAQQPQQFAYPQPQIPPghllpvqpsgqseylqqhv 385
Cdd:PRK12323 360 MLAFRPGQ-----SGGGAGPAT------AAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAA------------------- 409
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   386 aglqPPSPAQPSSTGAAASPATAATLPVGTGQNASSVGAqlmGASSQPSEAMAPRTGPAQGGQVAPCQPTGVPPATVGGV 465
Cdd:PRK12323 410 ----PAAAAAARAVAAAPARRSPAPEALAAARQASARGP---GGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPAR 482
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   466 VQPclGPAGAGQPQSVP-----PPQMGGSGPLSAVPGGPHAVVPGVPNvPAAVPAPSVPSVSTTSVTMPNVPAPLAQSQQ 540
Cdd:PRK12323 483 AAP--AAAPAPADDDPPpweelPPEFASPAPAQPDAAPAGWVAESIPD-PATADPDDAFETLAPAPAAAPAPRAAAATEP 559
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7662236   541 LSSHTPVSRSSSIIQHVglpLAPGTHSAPTSLPQSDLSQFQTQTQPLVGQVDDTRRKSEPLPQ 603
Cdd:PRK12323 560 VVAPRPPRASASGLPDM---FDGDWPALAARLPVRGLAQQLARQSELAGVEGDTVRLRVPVPA 619
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
289-621 4.60e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 50.37  E-value: 4.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   289 SAPLPPFPGAATGPQPMMAAAQPSQPQGAGPGGQTLPPTNVTLAQPAMSLPPQPGPAVGAP---AAQQPQQFAYPQPQIP 365
Cdd:PRK07764 388 AGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNApagGAPSPPPAAAPSAQPA 467
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   366 PGHLLPVQPSGQSEYlQQHVAGLQPPSPAQPSSTGAAASPATAATLP------VGTGQNASSVGAQLMGASSQ------- 432
Cdd:PRK07764 468 PAPAAAPEPTAAPAP-APPAAPAPAAAPAAPAAPAAPAGADDAATLRerwpeiLAAVPKRSRKTWAILLPEATvlgvrgd 546
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   433 ------PSEAMAPR---------------------------TGPAQGGQVAPCQPTGVPPATVGGVVQPCLGPAGAGQPQ 479
Cdd:PRK07764 547 tlvlgfSTGGLARRfaspgnaevlvtalaeelggdwqveavVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAA 626
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   480 SVPPPQMGGSGPLSAVPGGPHAVVPGVPNVPAAVPAPSVPSVSTTSVTMPNVPAPLAQSQQLSSHTPVSRSSSIiqhvgl 559
Cdd:PRK07764 627 PAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQ------ 700
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 7662236   560 PLAPGTHSAPTSLPQSDLSQFQTQTQPLVGQVDDTRRKSEPLPQPPLSLIAENKPVVKPPVA 621
Cdd:PRK07764 701 PAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPP 762
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
253-445 8.58e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 49.21  E-value: 8.58e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   253 PPSEKMSQPTPAQPQSFSVGQPQPPPPPVGGAVAQSSAPLPPFPGAATGPQPMMAAAQPSQPQGAGPGGQTLPPTNVTLA 332
Cdd:PRK07764 602 APASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAP 681
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   333 QPAMSLPPQPGPAVGAPAAQQPQQFAYPQPQIPPGHLLPVQPSGQSEYLQQHVAGLQPPSPAQPSSTGAAASPATAATLP 412
Cdd:PRK07764 682 PPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPP 761
                        170       180       190
                 ....*....|....*....|....*....|...
gi 7662236   413 VGTGQNASSVGAQLMGASSQPSEAMAPRTGPAQ 445
Cdd:PRK07764 762 PAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMD 794
PRK10263 PRK10263
DNA translocase FtsK; Provisional
289-484 1.90e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 48.54  E-value: 1.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    289 SAPLPPFPGAATGPQPMMAAAQPSQPQGAGPGGQTLPptnvtlAQPAMSLPPQPGPAVGAPA-AQQPQQFAyPQPQIPPg 367
Cdd:PRK10263  317 TEPVAVAAAATTATQSWAAPVEPVTQTPPVASVDVPP------AQPTVAWQPVPGPQTGEPViAPAPEGYP-QQSQYAQ- 388
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    368 hllpvQPSGQSEYLQQhvaglqppsPAQPSSTGAAASPATAATLPVGTGQNASSVGAQLMGASSQPSEAMAPRTGPAQGG 447
Cdd:PRK10263  389 -----PAVQYNEPLQQ---------PVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQS 454
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 7662236    448 QVAPcQPTGVPPATvggVVQPCLGPAGAGQPQSVPPP 484
Cdd:PRK10263  455 TFAP-QSTYQTEQT---YQQPAAQEPLYQQPQPVEQQ 487
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
240-460 3.13e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 47.56  E-value: 3.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   240 SGTDSSLTAVSQLPpsekMSQPTPAQPQSFSVGQPQPPPPPVGGAVAQSSAPLPPFPGAATGPQPMMAAAQPSQPQGAGP 319
Cdd:PRK12323 368 SGGGAGPATAAAAP----VAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARG 443
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   320 GGQTLPPTNVTLAQPAMSLPPQPGPAVGAPAA-------QQPQQFAYPQPQ-IPPGHLLPVQPSgqseylqqhVAGLQPP 391
Cdd:PRK12323 444 PGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAaaaaparAAPAAAPAPADDdPPPWEELPPEFA---------SPAPAQP 514
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 7662236   392 SPAQPSSTGAAASPATAATLPVGTGQNASSVGAQLMGASSQPSEAMAPRTGPAQGGQVAPCQPTGVPPA 460
Cdd:PRK12323 515 DAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGDWPA 583
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
238-432 3.19e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 47.72  E-value: 3.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    238 PESGTDSSLTAVSQLPPSEKM-----------SQPTPAQPQSFSVGQPQPPPPPVGGAVAQSSAPLPPfpgaatgPQPMM 306
Cdd:pfam09770 173 PAPAPQPAAQPASLPAPSRKMmsleeveaamrAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQI-------QQQQQ 245
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    307 AAAQPSQPQGagPGGQTLPPTNVTLAQpamSLPPQPGPAVGAPAAQQPQQFAYPQPQiPPGHLLPvQPSGQSEYLQQHVA 386
Cdd:pfam09770 246 PQQQPQQPQQ--HPGQGHPVTILQRPQ---SPQPDPAQPSIQPQAQQFHQQPPPVPV-QPTQILQ-NPNRLSAARVGYPQ 318
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 7662236    387 GLQPPSPAQPSSTGAAASPATAATLPVGTGQnassvgAQLMGASSQ 432
Cdd:pfam09770 319 NPQPGVQPAPAHQAHRQQGSFGRQAPIITHP------QQLAQLSEE 358
PRK10263 PRK10263
DNA translocase FtsK; Provisional
289-534 4.41e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 47.39  E-value: 4.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    289 SAPLPPFPGAATGPQPMMAAAQPSQPQGAGPGGQTLPPtnvTLAQPAMSLPPQPGPAVGAPAAQQPQQFAYPqPQIPPGH 368
Cdd:PRK10263  334 AAPVEPVTQTPPVASVDVPPAQPTVAWQPVPGPQTGEP---VIAPAPEGYPQQSQYAQPAVQYNEPLQQPVQ-PQQPYYA 409
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    369 LLPVQPSGQSEYLQQHVAGLQPPSPA-QPSSTGAAASPATAATLPVGTGQNASSVGAQLMGASSQPSEAMAPRTGPaqgg 447
Cdd:PRK10263  410 PAAEQPAQQPYYAPAPEQPAQQPYYApAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPAAQEPLYQQPQPVE---- 485
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    448 qvapcQPTGVPPATVGGVVQPCLGPAG----------------AGQPQSVPPPQMGGSGPLSAVPGGPHAVVPGVPNVPA 511
Cdd:PRK10263  486 -----QQPVVEPEPVVEETKPARPPLYyfeeveekrarereqlAAWYQPIPEPVKEPEPIKSSLKAPSVAAVPPVEAAAA 560
                         250       260
                  ....*....|....*....|....
gi 7662236    512 AVP-APSVPSVSTTSVTMPNVPAP 534
Cdd:PRK10263  561 VSPlASGVKKATLATGAAATVAAP 584
ZIP_MycBP-like cd21937
leucine zipper domain found in c-Myc-binding protein and similar proteins; MycBP, also called ...
693-745 5.65e-05

leucine zipper domain found in c-Myc-binding protein and similar proteins; MycBP, also called associate of Myc 1 (AMY-1), is a novel c-Myc binding protein that may control the transcriptional activity of Myc. It stimulates the activation of E box-dependent transcription by Myc. This model corresponds to the conserved region that shows high sequence similarity with the leucine zipper (ZIP) domain located at the C-terminus of TGF-beta-stimulated clone-22 domain (TSC22D) family transcription factors. The first helix of ZIP is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.


Pssm-ID: 409277 [Multi-domain]  Cd Length: 53  Bit Score: 41.38  E-value: 5.65e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 7662236  693 AMDLVKSHL--MYAVREEVEVLKEQIKELVERNSLLERENALLKSlssndQLSQL 745
Cdd:cd21937   3 ALDFIKQHLgaPGPEDADVEALRLENEELKQKNEELEEENKELKA-----KLQQY 52
PHA03247 PHA03247
large tegument protein UL36; Provisional
321-658 1.28e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 1.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    321 GQTLPPTNVTLAQPAMSLPPQPGPAVGAPAAQQPQQFAYPQPQIPPGHLLPVQPSGQS-------------EYLQQHVAG 387
Cdd:PHA03247 2471 GELFPGAPVYRRPAEARFPFAAGAAPDPGGGGPPDPDAPPAPSRLAPAILPDEPVGEPvhprmltwirgleELASDDAGD 2550
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    388 LQPPSPAQPSSTGAAASPATAATLPVGTGQNASSVGAQlMGASSQPSEAMAPRTGPaqGGQVAPCQPTGVPPATVGGVVQ 467
Cdd:PHA03247 2551 PPPPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARR-PDAPPQSARPRAPVDDR--GDPRGPAPPSPLPPDTHAPDPP 2627
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    468 PCLGPAGAGQPQSVPPPQMGGSGPLSAVPGGPHAVVPGVPNVPAAVPAPSVPSVSTTSVTMPNVPAPLAQSQQLSSHTPV 547
Cdd:PHA03247 2628 PPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPT 2707
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    548 SRSSSIIQHVGLPLAPGTHSAPTSLPQSDLSQFQTQT-QPLVGQVDDTRRKSEPLPQPPLSLIAENKPVVKPPVAdslan 626
Cdd:PHA03247 2708 PEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVpAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRR----- 2782
                         330       340       350
                  ....*....|....*....|....*....|..
gi 7662236    627 pLQLTPMNSLATSVFSIAIPVDGDEDRNPSTA 658
Cdd:PHA03247 2783 -LTRPAVASLSESRESLPSPWDPADPPAAVLA 2813
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
295-540 1.79e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 45.23  E-value: 1.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   295 FPGAATGPQPMMAAAQPSQPQGAGPGGQTLPPTNVTLAQPAMslPPQPGPAVGAPAAQQPQQFAYPQPQIPPGHLLPVQP 374
Cdd:PRK07003 358 FEPAVTGGGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAV--TAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPAT 435
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   375 SGQSEylqqhvAGLQPPSPAQPSSTGAAASPATAATLPvgtGQNASSVGAQLMGASSQPSEAMAPRTGPAqgGQVAPCQP 454
Cdd:PRK07003 436 ADRGD------DAADGDAPVPAKANARASADSRCDERD---AQPPADSGSASAPASDAPPDAAFEPAPRA--AAPSAATP 504
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   455 TGVPPATVGGVVQPCLGPAgagqPQSVPPPQMGGSGPLSAVP----GGPHAVV------------------PGVPNVPAA 512
Cdd:PRK07003 505 AAVPDARAPAAASREDAPA----AAAPPAPEARPPTPAAAAPaaraGGAAAALdvlrnagmrvssdrgaraAAAAKPAAA 580
                        250       260
                 ....*....|....*....|....*...
gi 7662236   513 VPAPSVPSVSTTSVTMPNVPAPLAQSQQ 540
Cdd:PRK07003 581 PAAAPKPAAPRVAVQVPTPRARAATGDA 608
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
306-550 2.31e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 44.84  E-value: 2.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   306 MAAAQPSQPQGAGPGGQTlpptnvtlaqpamslPPQPGPAVGAPAAQQPQqfaypqpqippghllpvqpsgqseylqqhV 385
Cdd:PRK07003 355 MLAFEPAVTGGGAPGGGV---------------PARVAGAVPAPGARAAA-----------------------------A 390
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   386 AGLQPPSPAQPSSTGAAASPATAATLPVGTGQNASSVGAQLMGASSQPSEAMAPRTGPAQGGQVAPCQPTGVPPATvggV 465
Cdd:PRK07003 391 VGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVPAKANARASADSRCDER---D 467
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   466 VQPCLGPA-GAGQPQSVPPPQMGGSGPLSAVPGGPHAVVPGVPNVPAAVPAPSVPSvsttsvtMPNVPAPLAQSQQLSSH 544
Cdd:PRK07003 468 AQPPADSGsASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPA-------AAAPPAPEARPPTPAAA 540

                 ....*.
gi 7662236   545 TPVSRS 550
Cdd:PRK07003 541 APAARA 546
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
438-627 2.50e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 44.46  E-value: 2.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   438 APRTGPAQGGQVAPCQPTGVPPAtvggvvqpclGPAGAGQPQSVPPPQMGGSGPLSAVPGGPHAVVPGVPNVPAAVPAPS 517
Cdd:PRK07003 361 AVTGGGAPGGGVPARVAGAVPAP----------GARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAP 430
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   518 VPSVSTTSVTMPNVPAPLAQSQQLSSHTPVSRSSSiiqhvgLPLAPGTHSAPTSLPQSDLSQFQT-QTQPLVGQVDDTRR 596
Cdd:PRK07003 431 APPATADRGDDAADGDAPVPAKANARASADSRCDE------RDAQPPADSGSASAPASDAPPDAAfEPAPRAAAPSAATP 504
                        170       180       190
                 ....*....|....*....|....*....|.
gi 7662236   597 KSEPLPQPPLSLIAENKPVVKPPVADSLANP 627
Cdd:PRK07003 505 AAVPDARAPAAASREDAPAAAAPPAPEARPP 535
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
297-605 2.69e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 44.59  E-value: 2.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   297 GAATGPQPMMAAAQPSQPQGAGPGGQTLPPTNVTLAQPAMSLPPQPGPAVGAPAAQQPQQfAYPQPQIPPGHLLPVQPSG 376
Cdd:PRK07764 365 PSASDDERGLLARLERLERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPA-PAAAPQPAPAPAPAPAPPS 443
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   377 QSEYLQQHVAGLQPPSPAQPSStgaaaspataatlPVGTGQNASSVGAQlmgASSQPSEAMAPRTGPAQGGQVAPCQPTG 456
Cdd:PRK07764 444 PAGNAPAGGAPSPPPAAAPSAQ-------------PAPAPAAAPEPTAA---PAPAPPAAPAPAAAPAAPAAPAAPAGAD 507
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   457 ---------------------------VPPATVGGVVQPCL--------------------------------------- 470
Cdd:PRK07764 508 daatlrerwpeilaavpkrsrktwailLPEATVLGVRGDTLvlgfstgglarrfaspgnaevlvtalaeelggdwqveav 587
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   471 --GPAGAGQPQSVPPPQMGGSGPLSAVPGGP-HAVVPGVPNVPAAVPAPSVPSVSTTSVTMPNVPAPLAQSQQLSSHTPV 547
Cdd:PRK07764 588 vgPAPGAAGGEGPPAPASSGPPEEAARPAAPaAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGD 667
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 7662236   548 SRSSSIIQHVGLPLAPGTHSAPtslPQSDLSQFQTQTQPLVGQVDDTRRKSEPLPQPP 605
Cdd:PRK07764 668 GWPAKAGGAAPAAPPPAPAPAA---PAAPAGAAPAQPAPAPAATPPAGQADDPAAQPP 722
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
307-521 3.76e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 44.21  E-value: 3.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   307 AAAQPSQPQGAGPGGQTLPPTNVTLAQPAMSLPP--QPGPAVGAPAAQQPQQFAYPQPQIPPGHLLPVQPSGQSEYLQQH 384
Cdd:PRK07764 588 VGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPaaPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGD 667
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   385 VAGLQPPSPAQPSSTGAAASPATAATLPVGTGQNASSVGAQLMGASSQpSEAMAPRTGPAQGGQVAPCQPTGVPPATvgg 464
Cdd:PRK07764 668 GWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQAD-DPAAQPPQAAQGASAPSPAADDPVPLPP--- 743
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 7662236   465 vvQPCLGPAGAGQPQSVPPPQMGGSGPLSAVPGGPHAVVPGVPNVPAAVPAPSVPSV 521
Cdd:PRK07764 744 --EPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMDDEDR 798
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
209-366 5.24e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.44  E-value: 5.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   209 DQTAERDSGLGATGGSVVVVVASMQGAHGPESGTDSSLTaVSQLPPSEKMSQPTPAQPQSFSVGQPQPPPPPVGGAVAQS 288
Cdd:PRK07764 627 PAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDG-GDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAP 705
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   289 SAPLPPFPGAATGPQPMMAAAQPSQPQGAGPGGQTLPPT---NVTLAQPAMSLPPQPGPAVGAPAAQQPQQFAYPQPQIP 365
Cdd:PRK07764 706 AATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEpddPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEM 785

                 .
gi 7662236   366 P 366
Cdd:PRK07764 786 A 786
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
232-356 5.83e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 43.23  E-value: 5.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   232 MQGAHGPESGTDSSLTAVSQLPPSEKMSQPTPAQPQSfsVGQPQPPPPPVGGAVAQSSAPlPPFPGAATGPQPM---MAA 308
Cdd:PRK14971 357 IQLAQLTQKGDDASGGRGPKQHIKPVFTQPAAAPQPS--AAAAASPSPSQSSAAAQPSAP-QSATQPAGTPPTVsvdPPA 433
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 7662236   309 AQPSQPQGAGPgGQTLPPTNVTLAQPAMSLPPQPGPAVGAPAAQQPQQ 356
Cdd:PRK14971 434 AVPVNPPSTAP-QAVRPAQFKEEKKIPVSKVSSLGPSTLRPIQEKAEQ 480
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
287-543 6.48e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 43.30  E-value: 6.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   287 QSSAPLPPFPGAATGPQPMMAAAQPSQPQGAGPGGQTLPPtnvtlAQPAMSLPPQPGPAVGAPAAQQ-PQQFAYPQPQIP 365
Cdd:PRK07003 385 ARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAE-----APPAAPAPPATADRGDDAADGDaPVPAKANARASA 459
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   366 PGHLLPVQPSGQSEYLQQhvAGLQPPSPAQPSSTGAAASPATAATLPVGTGQNASSVGAQLMGASSQPSEAmAPRTGPAQ 445
Cdd:PRK07003 460 DSRCDERDAQPPADSGSA--SAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAAAAPP-APEARPPT 536
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   446 GGQVApcqptgvPPATVGGVVQPCLGPAGAGQPQSVPPPQMGGSGPLSAVPgGPHAVVPGVPNVPAAVPAPSVPSVSTTS 525
Cdd:PRK07003 537 PAAAA-------PAARAGGAAAALDVLRNAGMRVSSDRGARAAAAAKPAAA-PAAAPKPAAPRVAVQVPTPRARAATGDA 608
                        250
                 ....*....|....*...
gi 7662236   526 VTMPNVPAPLAQSQQLSS 543
Cdd:PRK07003 609 PPNGAARAEQAAESRGAP 626
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
296-378 1.04e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 42.49  E-value: 1.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    296 PGAATGPQPMMAAAQPSQPQGAGPGGQTLPPTNVTL---------AQPAMSLPPQPGPAVGAPAAQQPQQFAYPQPQIPP 366
Cdd:TIGR01628 405 PQQQFNGQPLGWPRMSMMPTPMGPGGPLRPNGLAPMnavrapsrnAQNAAQKPPMQPVMYPPNYQSLPLSQDLPQPQSTA 484
                          90
                  ....*....|..
gi 7662236    367 GHLLPVQPSGQS 378
Cdd:TIGR01628 485 SQGGQNKKLAQV 496
PHA03378 PHA03378
EBNA-3B; Provisional
311-520 1.19e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 42.36  E-value: 1.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   311 PSQPQGAGPGGQTLPPTNVTLAQPAMSLPPQPGPAVGAPAAQQPqqfaypqPQIPPGHLLPVQPSGQSEYLQQHVAGLQP 390
Cdd:PHA03378 673 PYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQR-------PAAATGRARPPAAAPGRARPPAAAPGRAR 745
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   391 PSPAQPSSTGAAASPATAATLPVGT-GQNASSVGAQLMGASSQPSEAMAPRTGPAQGG----QVAPCQPTGVPPATVGGV 465
Cdd:PHA03378 746 PPAAAPGRARPPAAAPGRARPPAAApGAPTPQPPPQAPPAPQQRPRGAPTPQPPPQAGptsmQLMPRAAPGQQGPTKQIL 825
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 7662236   466 VQPCLGPAGAGQPQSVPPPQMGGSGPLSAVPGGPHAVVPGVPNVPAAVPAPSVPS 520
Cdd:PHA03378 826 RQLLTGGVKRGRPSLKKPAALERQAAAGPTPSPGSGTSDKIVQAPVFYPPVLQPI 880
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
244-552 1.22e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.45  E-value: 1.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    244 SSLTAVSQLPPSEKMSQPTPAQPQSfsvGQPQPPPPPVGGAVAQSSA----PLPPFPGAATGPQPMMAAAQPSQPQGAGP 319
Cdd:pfam03154 226 APHTLIQQTPTLHPQRLPSPHPPLQ---PMTQPPPPSQVSPQPLPQPslhgQMPPMPHSLQTGPSHMQHPVPPQPFPLTP 302
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    320 G---GQTLPPTNVTLAQPAMSLPPQPGPAVGAPAAQQPQQ-------FAYPQPQIPPGHLLPVQPSGQSeylQQHVAGLQ 389
Cdd:pfam03154 303 QssqSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREqplppapLSMPHIKPPPTTPIPQLPNPQS---HKHPPHLS 379
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    390 PPSPAQ-PSSTGAAASPATAATLPVGTGQNASSVGAQLMGASSQPSEAMAPRTGPAQGGQVAPCQPTGVPPATVGGVVQP 468
Cdd:pfam03154 380 GPSPFQmNSNLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQ 459
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    469 CLGPAGAGQPQSVPPPQMGGSGPLSAVPGGPHAVVPGVPNVPAAVPAPSVPSVSTTSVTMPNvpAPLAQSQQLSSHTPVS 548
Cdd:pfam03154 460 SPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQIKE--EALDEAEEPESPPPPP 537

                  ....
gi 7662236    549 RSSS 552
Cdd:pfam03154 538 RSPS 541
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
429-586 1.23e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.39  E-value: 1.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   429 ASSQPSEAMAPRTGPAQGGQVAPCqPTGVPPATVGGVVQPclGPAGAGQPQSVPPPqmggsgplsavpggphAVVPGVPN 508
Cdd:PRK14951 367 AAAAEAAAPAEKKTPARPEAAAPA-AAPVAQAAAAPAPAA--APAAAASAPAAPPA----------------AAPPAPVA 427
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 7662236   509 VPAAVPAPSVPSVSTTSVTMPnvPAPLAQSQQLSSHTPVsRSSSIIQHVGLPLAPGTHSAPTSLPQSDLSQFQTQTQP 586
Cdd:PRK14951 428 APAAAAPAAAPAAAPAAVALA--PAPPAQAAPETVAIPV-RVAPEPAVASAAPAPAAAPAAARLTPTEEGDVWHATVQ 502
PRK10263 PRK10263
DNA translocase FtsK; Provisional
251-396 1.25e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 42.38  E-value: 1.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    251 QLPPSEKMSQPTPAQPQSFSVGQPQPPPPPVGGAVAQSSAPLPPFPGAATGPQPMMAAAQPSQ----PQGAGPGGQTLPP 326
Cdd:PRK10263  728 EFSPMKALLDDGPHEPLFTPIVEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQyqqpQQPVAPQPQYQQP 807
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 7662236    327 TNVTLAQPAMSLPPQPgpAVGAPAAQQPQQFAYPQPQIPPGHLLPVQpSGQSEYLQQHVAGL-------QPPSPAQP 396
Cdd:PRK10263  808 QQPVAPQPQYQQPQQP--VAPQPQYQQPQQPVAPQPQDTLLHPLLMR-NGDSRPLHKPTTPLpsldlltPPPSEVEP 881
PHA03378 PHA03378
EBNA-3B; Provisional
294-499 1.55e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 41.98  E-value: 1.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   294 PFPGAATGPQPMMAAAQPSQPQGAGPGGQTLPPTNVTLAQPAMSLPPQPGPAVGAPAAQQPQQFA---YPQPQIPPGHLL 370
Cdd:PHA03378 696 PPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAApgrARPPAAAPGAPT 775
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   371 PVQPSGQSEYLQQHVAGlqPPSPAQPSSTGAAASPATAATLPVGTGQNASSVGAQLMGASSQPSEAMAPrtgPAQGGQVA 450
Cdd:PHA03378 776 PQPPPQAPPAPQQRPRG--APTPQPPPQAGPTSMQLMPRAAPGQQGPTKQILRQLLTGGVKRGRPSLKK---PAALERQA 850
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 7662236   451 PCQPTGVPPATVGG-VVQPCLGPAGAGQPQSVpPPQMGGSGPL--SAVPGGP 499
Cdd:PHA03378 851 AAGPTPSPGSGTSDkIVQAPVFYPPVLQPIQV-MRQLGSVRAAaaSTVTQAP 901
PHA03378 PHA03378
EBNA-3B; Provisional
296-639 1.57e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 41.98  E-value: 1.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   296 PGAATGPQPMmaaAQPSQPQGaGPGGQTLPPTNVTLAQPAMSLPPQPGpavgAPAAQQPQQFAypqpqiPPGHLLPVQPS 375
Cdd:PHA03378 590 PSYAQTPWPV---PHPSQTPE-PPTTQSHIPETSAPRQWPMPLRPIPM----RPLRMQPITFN------VLVFPTPHQPP 655
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   376 GQSEYLQQHVAGLQPPSPAQPSstgaaaspataatlpvgTGQNASSVGAQLMGASSQPSEAMAPRTGPAQGGQVAPCQPT 455
Cdd:PHA03378 656 QVEITPYKPTWTQIGHIPYQPS-----------------PTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPA 718
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   456 GVPPATVGGVVQPCLGPAGAGQPQSVPPPQM--GGSGPLSAVPGgPHAVVPGVPNVPAAVPAPSVPsvsttsvtmpnvPA 533
Cdd:PHA03378 719 AATGRARPPAAAPGRARPPAAAPGRARPPAAapGRARPPAAAPG-RARPPAAAPGAPTPQPPPQAP------------PA 785
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   534 PLAQSQQLSSHTPVSRSSSIIQHVGLPLAPGTHSAPTSLPQSDLSQFQTQTQPLVGQVDDTRRKS----EPLPQPPLSLI 609
Cdd:PHA03378 786 PQQRPRGAPTPQPPPQAGPTSMQLMPRAAPGQQGPTKQILRQLLTGGVKRGRPSLKKPAALERQAaagpTPSPGSGTSDK 865
                        330       340       350
                 ....*....|....*....|....*....|
gi 7662236   610 AENKPVVKPPVADSLANPLQLTPMNSLATS 639
Cdd:PHA03378 866 IVQAPVFYPPVLQPIQVMRQLGSVRAAAAS 895
PRK13169 PRK13169
DNA replication initiation control protein YabA;
707-759 2.77e-03

DNA replication initiation control protein YabA;


Pssm-ID: 183876  Cd Length: 110  Bit Score: 38.30  E-value: 2.77e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 7662236   707 EEVEVLKEQIKELVERNSLLERENALLKslssnDQLSQLpTQQANPGSTSQQQ 759
Cdd:PRK13169  22 KELGALKKQLAELLEENTALRLENDKLR-----ERLEEL-EAEEPAKEKKKKE 68
ZapB pfam06005
Cell division protein ZapB; ZapB is a non-essential, abundant cell division factor that is ...
707-749 3.21e-03

Cell division protein ZapB; ZapB is a non-essential, abundant cell division factor that is required for proper Z-ring formation.


Pssm-ID: 428718 [Multi-domain]  Cd Length: 71  Bit Score: 36.86  E-value: 3.21e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 7662236    707 EEVEVLKEQIKELVERNSLLERENALLKslSSNDQLSQLPTQQ 749
Cdd:pfam06005  18 DTIALLQMENEELKEENEELKEEANELE--EENQQLKQERNQW 58
PHA03378 PHA03378
EBNA-3B; Provisional
261-485 3.52e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 40.82  E-value: 3.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   261 PTPAQPQSFSVGQPQPPPPPVGGAVAQSSAP--LPPFPGAATGPQPMMAAAQPSQPQGAGPGgqTLPPTNVTLAQPAMSL 338
Cdd:PHA03378 701 PTPMRPPAAPPGRAQRPAAATGRARPPAAAPgrARPPAAAPGRARPPAAAPGRARPPAAAPG--RARPPAAAPGAPTPQP 778
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   339 PPQPGPAvgapAAQQPQQFAYPQ--PQIPPG--HLLPVQPSGQSEYLQQHVAGLQPPSPAQPSSTGAAASPATAATLPVG 414
Cdd:PHA03378 779 PPQAPPA----PQQRPRGAPTPQppPQAGPTsmQLMPRAAPGQQGPTKQILRQLLTGGVKRGRPSLKKPAALERQAAAGP 854
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 7662236   415 TGQNASSVGAQLMGASSQPSEAMAPRTGPAQGGQVAPCQPTGVPPATVGGVVQPCLGpaGAGQPQSVPPPQ 485
Cdd:PHA03378 855 TPSPGSGTSDKIVQAPVFYPPVLQPIQVMRQLGSVRAAAASTVTQAPTEYTGERRGV--GPMHPTDIPPSK 923
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
475-648 4.58e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 40.62  E-value: 4.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   475 AGQPQSVPPPQMGGSGPLSAVPGGPHAVVPGVPNVPAAVPAPSVPSVSTTSVTMPNVPAPLAQSQQLSSHTPVSRSSSIi 554
Cdd:PRK07994 363 APLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQGATKAKKS- 441
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   555 qhvgLPLAPGThSAPTSLPQSDLSQFQTQTQPLVGQVDdtrrKSEPLPQPPLSLIAENKPVVKPPVAdsLANPLQLTPMN 634
Cdd:PRK07994 442 ----EPAAASR-ARPVNSALERLASVRPAPSALEKAPA----KKEAYRWKATNPVEVKKEPVATPKA--LKKALEHEKTP 510
                        170
                 ....*....|....
gi 7662236   635 SLATSVFSIAIPVD 648
Cdd:PRK07994 511 ELAAKLAAEAIERD 524
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
287-649 4.86e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.52  E-value: 4.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    287 QSSAPLPPFPGAATGPQPMMAAAQPSQPQGAGPGGQTLPPTNVTLAQPAMSLPPQPGPAVGAPAAqqPQQFAYPQPQIPP 366
Cdd:pfam03154 142 RSTSPSIPSPQDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSV--PPQGSPATSQPPN 219
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    367 GHLLPVQPSGqseyLQQHVAGLQPPSPAQPSSTGAAASPataatlPVGTGQNASSVGAQLMGASSQPSEAMAPRTGPAQG 446
Cdd:pfam03154 220 QTQSTAAPHT----LIQQTPTLHPQRLPSPHPPLQPMTQ------PPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHM 289
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    447 GQVAPCQPTGVPPATVGGVVQPCLGPAGAGQPQSVPPPQMGGSGPLSAVPGGPHAVVPGVPNVPAAVPAPSVPsvsttsv 526
Cdd:pfam03154 290 QHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTP------- 362
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    527 tMPNVPAPLAQSQ--QLSSHTPVSRSSSIIQHVGL-PLA-------PGTHSAPTSL-PQSDLSQ---------FQTQTQP 586
Cdd:pfam03154 363 -IPQLPNPQSHKHppHLSGPSPFQMNSNLPPPPALkPLSslsthhpPSAHPPPLQLmPQSQQLPpppaqppvlTQSQSLP 441
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 7662236    587 LVGQVDDTRRKSEPLPQ----PPLSLIAENKPVVKPPVADSLANPLQLTPMNSLATSVFSIAIPVDG 649
Cdd:pfam03154 442 PPAASHPPTSGLHQVPSqspfPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPA 508
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
300-486 6.03e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 40.02  E-value: 6.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    300 TGPQPMMAAAQPSQPQGAGPGGQTLPPTNVTL--AQPAMSLPPQPgpavgapAAQQPQQFAYPQPQIPPGH--------- 368
Cdd:pfam09770 165 VAPKKAAAPAPAPQPAAQPASLPAPSRKMMSLeeVEAAMRAQAKK-------PAQQPAPAPAQPPAAPPAQqaqqqqqfp 237
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236    369 ---LLPVQPSGQSEYLQQHVAGLQPPSPAQ-PSSTGAAASPATAATLPVGTGQNASSVGAQLMGASSQPSEAMAPRTGpa 444
Cdd:pfam09770 238 pqiQQQQQPQQQPQQPQQHPGQGHPVTILQrPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNRLSAARVG-- 315
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 7662236    445 qggqvAPCQPTGVPPATVGGVVQPCLGPAGAGQPQSVPPPQM 486
Cdd:pfam09770 316 -----YPQNPQPGVQPAPAHQAHRQQGSFGRQAPIITHPQQL 352
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
431-547 6.21e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.08  E-value: 6.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   431 SQPSEAMAPRTGPAQGGQVAPCQPTGVPPATVGGVVQPCLGPAGAGQPQSVPPPQMGGSGPLSAVPGGPHAVVPGvPNVP 510
Cdd:PRK14951 395 AQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAPAPPAQAAPETVAIPVRVAPE-PAVA 473
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 7662236   511 AAVPAPSVPSVSTTSVTMPNVPAPLAQSQQLSSHTPV 547
Cdd:PRK14951 474 SAAPAPAAAPAAARLTPTEEGDVWHATVQQLAAAEAI 510
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
216-483 1.00e-02

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 39.45  E-value: 1.00e-02
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   216 SGLGATGGSVVVVVASMQGAHGPESGTDSSLTAVSQLPPSeKMSQPTPAQPQSFSVGQPQPPPPPVGGAVAQSSAPLPPF 295
Cdd:PRK07003 363 TGGGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAV-TGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDD 441
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   296 PGAATGPQPMMAAAQPSQPQGAGPGGQTLPPTNVTLAQPAMSLPPQPGPAVGAPAAQQPQQFAYPQPqiPPGHLLPVQPS 375
Cdd:PRK07003 442 AADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVP--DARAPAAASRE 519
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236   376 GQSEYLQQHVAGLQPPSPAQPSSTGAAASPATAATLPVGTGQNASSVGAQLMGASSQPSEAMAPRTGPAQGGQVAPC-QP 454
Cdd:PRK07003 520 DAPAAAAPPAPEARPPTPAAAAPAARAGGAAAALDVLRNAGMRVSSDRGARAAAAAKPAAAPAAAPKPAAPRVAVQVpTP 599
                        250       260
                 ....*....|....*....|....*....
gi 7662236   455 TGVPPATVGGVVQPCLGPAGAGQPQSVPP 483
Cdd:PRK07003 600 RARAATGDAPPNGAARAEQAAESRGAPPP 628
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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