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Conserved domains on  [gi|7657619|ref|NP_055282|]
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sushi repeat-containing protein SRPX2 precursor [Homo sapiens]

Protein Classification

beta-2-glycoprotein 1( domain architecture ID 10034342)

beta-2-glycoprotein 1 is a heavily glycosylated plasma membrane-adhesion protein, which plays a role in blood coagulation and removal of apoptotic bodies

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4174 pfam13778
Domain of unknown function (DUF4174); This domain of unknown function is found in a putative ...
 334-453 1.80e-51

Domain of unknown function (DUF4174); This domain of unknown function is found in a putative tumour suppressor gene and in a ligand for the the urokinase-type plasminogen activator receptor, which plays a role in cellular migration and adhesion.


:

Pssm-ID: 463980  Cd Length: 120  Bit Score: 170.12  E-value: 1.80e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657619    334 LLDQFYEKQRLLIISAPDPSNRYYKMQISMLQQSTCGLDLRHVTIIELVGQPPQEVGRIREQQLSANIIEELRQFQRLTR 413
Cdd:pfam13778   1 PLDQFRWKRRLLIISAPSADDPYYRQQLDALQAAECGLAERDLTVIELVGSGPNETGKIEHEQLSPDLIEELRKELGIPR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 7657619    414 SYFNMVLIDKQGIDRDRYMEPVTPEEIFTFIDDYLLSNQE 453
Cdd:pfam13778  81 NYFSMVLIGKDGGVKERYPAPVSLEALFDLIDAMPMRQQE 120
HYR pfam02494
HYR domain; This domain is known as the HYR (Hyalin Repeat) domain, after the protein hyalin ...
 177-259 2.43e-36

HYR domain; This domain is known as the HYR (Hyalin Repeat) domain, after the protein hyalin that is composed exclusively of this repeat. This domain probably corresponds to a new superfamily in the immunoglobulin fold. The function of this domain is uncertain it may be involved in cell adhesion.


:

Pssm-ID: 460572 [Multi-domain]  Cd Length: 81  Bit Score: 128.66  E-value: 2.43e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657619    177 VDIDPPKIRCPHSREKMAEPEKLTARVYWDPPLVKDSADGTItrVTLRGPEPGSHFPEGEHVIRYTAYDRAYNRASCKFI 256
Cdd:pfam02494   1 VDTTPPTVKCPNNIVRTVELGTSTVRVFFTEPTAFDNSGQAI--LVSRTAQPGDFFPVGTTTVTYVAYDNSGNRASCTFT 78


                  ...
gi 7657619    257 VKV 259
Cdd:pfam02494  79 VTV 81
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 264-319 1.05e-13

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 65.56  E-value: 1.05e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 7657619  264 CPTLKPPQHGYLTCTSAGDNYGATCEYHCDGGYDRQGTPSRVCQSSRQWSGSPPIC 319
Cdd:cd00033   1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 122-177 3.00e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 58.63  E-value: 3.00e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 7657619  122 CHALPFITSGTYTCTNGV-LLDSRCDYSCSSGYHLEGDRSRICMEDGRWSGGEPVCV 177
Cdd:cd00033   1 CPPPPVPENGTVTGSKGSySYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 72-114 1.43e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 42.45  E-value: 1.43e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 7657619   72 YSPKGGNYhsSLGTRCELSCDRGFRLIGRRSVQCLPSRRWSGT 114
Cdd:cd00033  12 VTGSKGSY--SYGSTVTYSCNEGYTLVGSSTITCTENGGWSPP 52
 
Name Accession Description Interval E-value
DUF4174 pfam13778
Domain of unknown function (DUF4174); This domain of unknown function is found in a putative ...
 334-453 1.80e-51

Domain of unknown function (DUF4174); This domain of unknown function is found in a putative tumour suppressor gene and in a ligand for the the urokinase-type plasminogen activator receptor, which plays a role in cellular migration and adhesion.


Pssm-ID: 463980  Cd Length: 120  Bit Score: 170.12  E-value: 1.80e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657619    334 LLDQFYEKQRLLIISAPDPSNRYYKMQISMLQQSTCGLDLRHVTIIELVGQPPQEVGRIREQQLSANIIEELRQFQRLTR 413
Cdd:pfam13778   1 PLDQFRWKRRLLIISAPSADDPYYRQQLDALQAAECGLAERDLTVIELVGSGPNETGKIEHEQLSPDLIEELRKELGIPR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 7657619    414 SYFNMVLIDKQGIDRDRYMEPVTPEEIFTFIDDYLLSNQE 453
Cdd:pfam13778  81 NYFSMVLIGKDGGVKERYPAPVSLEALFDLIDAMPMRQQE 120
HYR pfam02494
HYR domain; This domain is known as the HYR (Hyalin Repeat) domain, after the protein hyalin ...
 177-259 2.43e-36

HYR domain; This domain is known as the HYR (Hyalin Repeat) domain, after the protein hyalin that is composed exclusively of this repeat. This domain probably corresponds to a new superfamily in the immunoglobulin fold. The function of this domain is uncertain it may be involved in cell adhesion.


Pssm-ID: 460572 [Multi-domain]  Cd Length: 81  Bit Score: 128.66  E-value: 2.43e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657619    177 VDIDPPKIRCPHSREKMAEPEKLTARVYWDPPLVKDSADGTItrVTLRGPEPGSHFPEGEHVIRYTAYDRAYNRASCKFI 256
Cdd:pfam02494   1 VDTTPPTVKCPNNIVRTVELGTSTVRVFFTEPTAFDNSGQAI--LVSRTAQPGDFFPVGTTTVTYVAYDNSGNRASCTFT 78


                  ...
gi 7657619    257 VKV 259
Cdd:pfam02494  79 VTV 81
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 264-319 1.05e-13

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 65.56  E-value: 1.05e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 7657619  264 CPTLKPPQHGYLTCTSAGDNYGATCEYHCDGGYDRQGTPSRVCQSSRQWSGSPPIC 319
Cdd:cd00033   1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
264-319 9.13e-13

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 62.90  E-value: 9.13e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 7657619    264 CPTLKPPQHGYLTCTSAGDNYGATCEYHCDGGYDRQGTPSRVCQSSRQWSGSPPIC 319
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 264-319 4.08e-12

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 61.00  E-value: 4.08e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 7657619     264 CPTLKPPQHGYLTCTSAGDNYGATCEYHCDGGYDRQGTPSRVCQSSRQWSGSPPIC 319
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 122-177 3.00e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 58.63  E-value: 3.00e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 7657619  122 CHALPFITSGTYTCTNGV-LLDSRCDYSCSSGYHLEGDRSRICMEDGRWSGGEPVCV 177
Cdd:cd00033   1 CPPPPVPENGTVTGSKGSySYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 122-176 2.22e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 56.00  E-value: 2.22e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 7657619     122 CHALPFITSGTYTCTNGV-LLDSRCDYSCSSGYHLEGDRSRICMEDGRWSGGEPVC 176
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTySYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
122-176 8.38e-08

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 48.65  E-value: 8.38e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 7657619    122 CHALPFITSGTYTCTNGVLLD-SRCDYSCSSGYHLEGDRSRICMEDGRWSGGEPVC 176
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYgASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 72-114 1.43e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 42.45  E-value: 1.43e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 7657619   72 YSPKGGNYhsSLGTRCELSCDRGFRLIGRRSVQCLPSRRWSGT 114
Cdd:cd00033  12 VTGSKGSY--SYGSTVTYSCNEGYTLVGSSTITCTENGGWSPP 52
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 24-177 1.76e-05

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 46.18  E-value: 1.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657619    24 TWYAGSGYY---PDESYNE-------VYAEEVPQAPALDYRVPRwcytlNIQDGEATCYSpkggNYHSSlGTRCELSCDR 93
Cdd:PHA02927 109 TYSCNSGYQligESKSYCElgstgsmVWNPEAPICESVKCQSPP-----SISNGRHNGYE----DFYTD-GSVVTYSCNS 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657619    94 GFRLIGRRSVQClPSRRWSGTAYCRQMRChALPFITSG--------TYTCTNGVlldsrcDYSCSSGYHLEGDRSRICME 165
Cdd:PHA02927 179 GYSLIGNSGVLC-SGGEWSDPPTCQIVKC-PHPTISNGylssgfkrSYSYNDNV------DFKCKYGYKLSGSSSSTCSP 250

                        170
                 ....*....|..
gi 7657619   166 DGRWSGGEPVCV 177
Cdd:PHA02927 251 GNTWQPELPKCV 262
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 82-115 4.48e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 40.97  E-value: 4.48e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 7657619      82 SLGTRCELSCDRGFRLIGRRSVQCLPSRRWSGTA 115
Cdd:smart00032  20 SYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPP 53
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 82-177 1.58e-04

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 43.54  E-value: 1.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657619    82 SLGTRCELSCDRGFRLIGRRSVQClPSRRWSGTAYCRQmRCHaLPFIT----SGTYTCTNGVLldsrcDYSCSSGYHLEG 157
Cdd:PHA02954 148 SFGEHITINCDVGYEVIGASYISC-TANSWNVIPSCQQ-KCD-IPSLSngliSGSTFSIGGVI-----HLSCKSGFTLTG 219

                         90       100
                 ....*....|....*....|
gi 7657619   158 DRSRICMeDGRWSGGEPVCV 177
Cdd:PHA02954 220 SPSSTCI-DGKWNPVLPICV 238
Sushi pfam00084
Sushi repeat (SCR repeat);
84-114 3.15e-03

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 35.94  E-value: 3.15e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 7657619     84 GTRCELSCDRGFRLIGRRSVQCLPSRRWSGT 114
Cdd:pfam00084  22 GASVSYECDPGYRLVGSPTITCQEDGTWSPP 52
 
Name Accession Description Interval E-value
DUF4174 pfam13778
Domain of unknown function (DUF4174); This domain of unknown function is found in a putative ...
 334-453 1.80e-51

Domain of unknown function (DUF4174); This domain of unknown function is found in a putative tumour suppressor gene and in a ligand for the the urokinase-type plasminogen activator receptor, which plays a role in cellular migration and adhesion.


Pssm-ID: 463980  Cd Length: 120  Bit Score: 170.12  E-value: 1.80e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657619    334 LLDQFYEKQRLLIISAPDPSNRYYKMQISMLQQSTCGLDLRHVTIIELVGQPPQEVGRIREQQLSANIIEELRQFQRLTR 413
Cdd:pfam13778   1 PLDQFRWKRRLLIISAPSADDPYYRQQLDALQAAECGLAERDLTVIELVGSGPNETGKIEHEQLSPDLIEELRKELGIPR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 7657619    414 SYFNMVLIDKQGIDRDRYMEPVTPEEIFTFIDDYLLSNQE 453
Cdd:pfam13778  81 NYFSMVLIGKDGGVKERYPAPVSLEALFDLIDAMPMRQQE 120
HYR pfam02494
HYR domain; This domain is known as the HYR (Hyalin Repeat) domain, after the protein hyalin ...
 177-259 2.43e-36

HYR domain; This domain is known as the HYR (Hyalin Repeat) domain, after the protein hyalin that is composed exclusively of this repeat. This domain probably corresponds to a new superfamily in the immunoglobulin fold. The function of this domain is uncertain it may be involved in cell adhesion.


Pssm-ID: 460572 [Multi-domain]  Cd Length: 81  Bit Score: 128.66  E-value: 2.43e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657619    177 VDIDPPKIRCPHSREKMAEPEKLTARVYWDPPLVKDSADGTItrVTLRGPEPGSHFPEGEHVIRYTAYDRAYNRASCKFI 256
Cdd:pfam02494   1 VDTTPPTVKCPNNIVRTVELGTSTVRVFFTEPTAFDNSGQAI--LVSRTAQPGDFFPVGTTTVTYVAYDNSGNRASCTFT 78


                  ...
gi 7657619    257 VKV 259
Cdd:pfam02494  79 VTV 81
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 264-319 1.05e-13

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 65.56  E-value: 1.05e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 7657619  264 CPTLKPPQHGYLTCTSAGDNYGATCEYHCDGGYDRQGTPSRVCQSSRQWSGSPPIC 319
Cdd:cd00033   1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
264-319 9.13e-13

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 62.90  E-value: 9.13e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 7657619    264 CPTLKPPQHGYLTCTSAGDNYGATCEYHCDGGYDRQGTPSRVCQSSRQWSGSPPIC 319
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 264-319 4.08e-12

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 61.00  E-value: 4.08e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 7657619     264 CPTLKPPQHGYLTCTSAGDNYGATCEYHCDGGYDRQGTPSRVCQSSRQWSGSPPIC 319
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 122-177 3.00e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 58.63  E-value: 3.00e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 7657619  122 CHALPFITSGTYTCTNGV-LLDSRCDYSCSSGYHLEGDRSRICMEDGRWSGGEPVCV 177
Cdd:cd00033   1 CPPPPVPENGTVTGSKGSySYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 122-176 2.22e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 56.00  E-value: 2.22e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 7657619     122 CHALPFITSGTYTCTNGV-LLDSRCDYSCSSGYHLEGDRSRICMEDGRWSGGEPVC 176
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTySYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
122-176 8.38e-08

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 48.65  E-value: 8.38e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 7657619    122 CHALPFITSGTYTCTNGVLLD-SRCDYSCSSGYHLEGDRSRICMEDGRWSGGEPVC 176
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYgASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 72-114 1.43e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 42.45  E-value: 1.43e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 7657619   72 YSPKGGNYhsSLGTRCELSCDRGFRLIGRRSVQCLPSRRWSGT 114
Cdd:cd00033  12 VTGSKGSY--SYGSTVTYSCNEGYTLVGSSTITCTENGGWSPP 52
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 24-177 1.76e-05

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 46.18  E-value: 1.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657619    24 TWYAGSGYY---PDESYNE-------VYAEEVPQAPALDYRVPRwcytlNIQDGEATCYSpkggNYHSSlGTRCELSCDR 93
Cdd:PHA02927 109 TYSCNSGYQligESKSYCElgstgsmVWNPEAPICESVKCQSPP-----SISNGRHNGYE----DFYTD-GSVVTYSCNS 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657619    94 GFRLIGRRSVQClPSRRWSGTAYCRQMRChALPFITSG--------TYTCTNGVlldsrcDYSCSSGYHLEGDRSRICME 165
Cdd:PHA02927 179 GYSLIGNSGVLC-SGGEWSDPPTCQIVKC-PHPTISNGylssgfkrSYSYNDNV------DFKCKYGYKLSGSSSSTCSP 250

                        170
                 ....*....|..
gi 7657619   166 DGRWSGGEPVCV 177
Cdd:PHA02927 251 GNTWQPELPKCV 262
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 82-115 4.48e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 40.97  E-value: 4.48e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 7657619      82 SLGTRCELSCDRGFRLIGRRSVQCLPSRRWSGTA 115
Cdd:smart00032  20 SYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPP 53
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 82-177 1.58e-04

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 43.54  E-value: 1.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657619    82 SLGTRCELSCDRGFRLIGRRSVQClPSRRWSGTAYCRQmRCHaLPFIT----SGTYTCTNGVLldsrcDYSCSSGYHLEG 157
Cdd:PHA02954 148 SFGEHITINCDVGYEVIGASYISC-TANSWNVIPSCQQ-KCD-IPSLSngliSGSTFSIGGVI-----HLSCKSGFTLTG 219

                         90       100
                 ....*....|....*....|
gi 7657619   158 DRSRICMeDGRWSGGEPVCV 177
Cdd:PHA02954 220 SPSSTCI-DGKWNPVLPICV 238
Sushi pfam00084
Sushi repeat (SCR repeat);
84-114 3.15e-03

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 35.94  E-value: 3.15e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 7657619     84 GTRCELSCDRGFRLIGRRSVQCLPSRRWSGT 114
Cdd:pfam00084  22 GASVSYECDPGYRLVGSPTITCQEDGTWSPP 52
PHA02639 PHA02639
EEV host range protein; Provisional
 95-181 9.69e-03

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 38.11  E-value: 9.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657619    95 FRLIGRRSVQCLPSRRWS-GTAYCRQMRCHaLPFITSGTytcTNGV------LLDSRCDYSCSSGYHLEGDRSRICMEDG 167
Cdd:PHA02639 121 YSLVGNEKITCIQDKSWKpDPPICKMINCR-FPALQNGY---INGIpsnkkfYYKTRVGFSCKSGFDLVGEKYSTCNINA 196

                         90
                 ....*....|....
gi 7657619   168 RWSGGEPVCVDIDP 181
Cdd:PHA02639 197 TWFPSIPTCVRNKP 210
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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