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Conserved domains on  [gi|7657441|ref|NP_055706|]
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28 kDa heat- and acid-stable phosphoprotein [Homo sapiens]

Protein Classification

PDGFA associated 1 family protein( domain architecture ID 10563020)

PDGFA associated 1 (PDAP1) family protein similar to human 28 kDa heat- and acid-stable phosphoprotein, also called PDAP1, that enhances PDGFA-stimulated cell growth in fibroblasts but inhibits the mitogenic effect of PDGFB

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PP28 pfam10252
Casein kinase substrate phosphoprotein PP28; This domain is a region of 70 residues conserved ...
 85-149 5.52e-21

Casein kinase substrate phosphoprotein PP28; This domain is a region of 70 residues conserved in proteins from plants to humans and contains a serine/arginine rich motif. In rats the full protein is a casein kinase substrate, and this region contains phosphorylation sites for both cAMP-dependent protein kinase and casein kinase II.


:

Pssm-ID: 463025 [Multi-domain]  Cd Length: 80  Bit Score: 81.86  E-value: 5.52e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 7657441     85 NPNRVA-QTTKKVTQLD-LDGPKELSRREREEIEKQKAKERYMKMHLAGKTEQAKADLARLAIIRKQ 149
Cdd:pfam10252   1 NPNRVKkAKNQKLADLDaADKPKELSRREREEIEKQKAKERYMKLHAEGKTEEAKADLARLALIRKQ 67
 
Name Accession Description Interval E-value
PP28 pfam10252
Casein kinase substrate phosphoprotein PP28; This domain is a region of 70 residues conserved ...
 85-149 5.52e-21

Casein kinase substrate phosphoprotein PP28; This domain is a region of 70 residues conserved in proteins from plants to humans and contains a serine/arginine rich motif. In rats the full protein is a casein kinase substrate, and this region contains phosphorylation sites for both cAMP-dependent protein kinase and casein kinase II.


Pssm-ID: 463025 [Multi-domain]  Cd Length: 80  Bit Score: 81.86  E-value: 5.52e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 7657441     85 NPNRVA-QTTKKVTQLD-LDGPKELSRREREEIEKQKAKERYMKMHLAGKTEQAKADLARLAIIRKQ 149
Cdd:pfam10252   1 NPNRVKkAKNQKLADLDaADKPKELSRREREEIEKQKAKERYMKLHAEGKTEEAKADLARLALIRKQ 67
 
Name Accession Description Interval E-value
PP28 pfam10252
Casein kinase substrate phosphoprotein PP28; This domain is a region of 70 residues conserved ...
 85-149 5.52e-21

Casein kinase substrate phosphoprotein PP28; This domain is a region of 70 residues conserved in proteins from plants to humans and contains a serine/arginine rich motif. In rats the full protein is a casein kinase substrate, and this region contains phosphorylation sites for both cAMP-dependent protein kinase and casein kinase II.


Pssm-ID: 463025 [Multi-domain]  Cd Length: 80  Bit Score: 81.86  E-value: 5.52e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 7657441     85 NPNRVA-QTTKKVTQLD-LDGPKELSRREREEIEKQKAKERYMKMHLAGKTEQAKADLARLAIIRKQ 149
Cdd:pfam10252   1 NPNRVKkAKNQKLADLDaADKPKELSRREREEIEKQKAKERYMKLHAEGKTEEAKADLARLALIRKQ 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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