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Conserved domains on  [gi|764011035|emb|CEQ36146|]
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EBNA-3A [human gammaherpesvirus 4]

Protein Classification

drebrin family protein( domain architecture ID 11476234)

drebrin family protein similar to the portion of Homo sapiens drebrin-like protein, an adapter protein that binds F-actin and DNM1, thus plays a role in receptor-mediated endocytosis

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
PHA03379 PHA03379
EBNA-3A; Provisional
1-944 0e+00

EBNA-3A; Provisional


:

Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 1565.43  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035   1 MDKDRPGPPAlDDNMEEEVPSTSVVQEQVSAGDWENVLIELSDSSSEKEAEDAHLEPAQKGTKRKRVDHDAGGSAPARPM 80
Cdd:PHA03379   1 MDKDRPGLPA-PDDNIEEVPSTSGVQEQASGGDWENVLIEDSDSSSEEEAEDAHLEPPQKGKKRKRVDDDAGGSAPAQPP 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035  81 LPPQPDLPGREAILRRFPLDLRTLLQAIGAAATRIDTRAIDQFFGSQISNTEMYIMYAMAIRQAIRDRRRNPASRRDQAK 160
Cdd:PHA03379  80 CPPQLDLPGREAILGRFPLDLRKLLQAIGAAATHPDTRAIDQFFGSQISNTQRYLMYAMAIRQAIRDRRRNPASRRCQNK 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 161 WRLQTLAAGWPMGYQAYSSWMYSYTDHQTTPTFVHLQATLGCTGGRRCHVTFSAGTFKLPRCTPGDRQWLYVQSSVGNIV 240
Cdd:PHA03379 160 WRLTTLAAGWPMGYQAYSSWMYSYTDDQRTPTRIHLQATLGCEEGRRCHVTFSAGTFKPPRCSPGDRQWLYVQSCVGELV 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 241 QSCNPRYSIFFDYMAIHRSLTKIWEEVLTPDQRVSFMEFLGFLQRTDLSYIKSFVSDALGTTSIQTPWIDDNPSTETAQA 320
Cdd:PHA03379 240 QSCNPIYSIFFDYMAIHRSLTKIWEEVLTPDQRVPFMEFLGFLQRTDLIYIKSFVSEALGTTSIQTPWLDENPSTETAQA 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 321 WNAGFLRGRAYGLDLLRTEGEHVEGATGETREESEDTESDGDDEDLPCIVSRGGPKVKRPPIFIRRLHRLLLMRAGKRTE 400
Cdd:PHA03379 320 WNAGLLRGRAYGLDLLRTEGEHDEGATGETREESEDTESDGDDEELPRIVSREGTKRKRPPIFLRRLHRLLLMRAGKLTE 399
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 401 QGKEVLEKARGSTYGTPRPPVPKPRPEVPQSDETATSHGSAQVPEPPTIHLAAQGmayPLHEQHGMAPCPVAQAPPTPLP 480
Cdd:PHA03379 400 RAREALEKASEPTYGTPRPPVEKPRPEVPQSLETATSHGSAQVPEPPPVHDLEPG---PLHDQHSMAPCPVAQLPPGPLQ 476
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 481 PVSPGDQLPGVSSDGRVACAPVPAPAGPIVRPWEPSLTQAAGQAFAPVRPQHMPVEPVPVPTVALERpvypkPVRPAPPK 560
Cdd:PHA03379 477 DLEPGDQLPGVVQDGRPACAPVPAPAGPIVRPWEASLSQVPGVAFAPVMPQPMPVEPVPVPTVALER-----PVCPAPPL 551
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 561 IAMQGPGETSGIRRARERWRPAPWTPNPPRSPSQMSVRDRLARLRAEAQVKQASVEVQPPQLTQVSPQQPMEGPLVPEQQ 640
Cdd:PHA03379 552 IAMQGPGETSGIVRVRERWRPAPWTPNPPRSPSQMSVRDRLARLRAEAQPYQASVEVQPPQLTQVSPQQPMEYPLEPEQQ 631
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 641 MFPGAPFSQVADVVRAPGVPAMQPQYFDLPLIQPISQGAPVAPLRASMGPVPPVPATQPQYFDIPLTEPINQGASAAHFL 720
Cdd:PHA03379 632 MFPGSPFSQVADVMRAGGVPAMQPQYFDLPLQQPISQGAPLAPLRASMGPVPPVPATQPQYFDIPLTEPINQGASAAHFL 711
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 721 PQQPMEGPLVPEQWMFPGAALSQSVRPGVAQSQYFDLPLTQPINHGAPAAHFLHQPPMEGPWVPEQWMFQGAPPSQGTDV 800
Cdd:PHA03379 712 PQQPMEGPLVPERWMFQGATLSQSVRPGVAQSQYFDLPLTQPINHGAPAAHFLHQPPMEGPWVPEQWMFQGAPPSQGTDV 791
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 801 VQHQLDALGYTLHGLNHPGVPVSPAVNQYYLSQAAFGLPIDEDESGEGSDTSEPCEALDLSIHGRPCPQAPEWPVQEEGG 880
Cdd:PHA03379 792 VQHQLDALGYVLHVLNHPGVPVSPAVNQYHVSQAAFGLPIDEDESGEGSDTSEPCEALDLSIHGRPCPQAPEWPVQGEGG 871
                        890       900       910       920       930       940
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 764011035 881 QDATEVLDLSIHGRPRPRTPEWPVQGEGGQNVTGPETRRVVVSAVVHMCQDDEFPDLQDPPDEA 944
Cdd:PHA03379 872 QDATEVLDLSIHGRPRPRTPEWPVQGEDGQNVTGAESRRVVVSALVHMCQDDEFPDLQDPPDEA 935
 
Name Accession Description Interval E-value
PHA03379 PHA03379
EBNA-3A; Provisional
1-944 0e+00

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 1565.43  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035   1 MDKDRPGPPAlDDNMEEEVPSTSVVQEQVSAGDWENVLIELSDSSSEKEAEDAHLEPAQKGTKRKRVDHDAGGSAPARPM 80
Cdd:PHA03379   1 MDKDRPGLPA-PDDNIEEVPSTSGVQEQASGGDWENVLIEDSDSSSEEEAEDAHLEPPQKGKKRKRVDDDAGGSAPAQPP 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035  81 LPPQPDLPGREAILRRFPLDLRTLLQAIGAAATRIDTRAIDQFFGSQISNTEMYIMYAMAIRQAIRDRRRNPASRRDQAK 160
Cdd:PHA03379  80 CPPQLDLPGREAILGRFPLDLRKLLQAIGAAATHPDTRAIDQFFGSQISNTQRYLMYAMAIRQAIRDRRRNPASRRCQNK 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 161 WRLQTLAAGWPMGYQAYSSWMYSYTDHQTTPTFVHLQATLGCTGGRRCHVTFSAGTFKLPRCTPGDRQWLYVQSSVGNIV 240
Cdd:PHA03379 160 WRLTTLAAGWPMGYQAYSSWMYSYTDDQRTPTRIHLQATLGCEEGRRCHVTFSAGTFKPPRCSPGDRQWLYVQSCVGELV 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 241 QSCNPRYSIFFDYMAIHRSLTKIWEEVLTPDQRVSFMEFLGFLQRTDLSYIKSFVSDALGTTSIQTPWIDDNPSTETAQA 320
Cdd:PHA03379 240 QSCNPIYSIFFDYMAIHRSLTKIWEEVLTPDQRVPFMEFLGFLQRTDLIYIKSFVSEALGTTSIQTPWLDENPSTETAQA 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 321 WNAGFLRGRAYGLDLLRTEGEHVEGATGETREESEDTESDGDDEDLPCIVSRGGPKVKRPPIFIRRLHRLLLMRAGKRTE 400
Cdd:PHA03379 320 WNAGLLRGRAYGLDLLRTEGEHDEGATGETREESEDTESDGDDEELPRIVSREGTKRKRPPIFLRRLHRLLLMRAGKLTE 399
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 401 QGKEVLEKARGSTYGTPRPPVPKPRPEVPQSDETATSHGSAQVPEPPTIHLAAQGmayPLHEQHGMAPCPVAQAPPTPLP 480
Cdd:PHA03379 400 RAREALEKASEPTYGTPRPPVEKPRPEVPQSLETATSHGSAQVPEPPPVHDLEPG---PLHDQHSMAPCPVAQLPPGPLQ 476
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 481 PVSPGDQLPGVSSDGRVACAPVPAPAGPIVRPWEPSLTQAAGQAFAPVRPQHMPVEPVPVPTVALERpvypkPVRPAPPK 560
Cdd:PHA03379 477 DLEPGDQLPGVVQDGRPACAPVPAPAGPIVRPWEASLSQVPGVAFAPVMPQPMPVEPVPVPTVALER-----PVCPAPPL 551
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 561 IAMQGPGETSGIRRARERWRPAPWTPNPPRSPSQMSVRDRLARLRAEAQVKQASVEVQPPQLTQVSPQQPMEGPLVPEQQ 640
Cdd:PHA03379 552 IAMQGPGETSGIVRVRERWRPAPWTPNPPRSPSQMSVRDRLARLRAEAQPYQASVEVQPPQLTQVSPQQPMEYPLEPEQQ 631
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 641 MFPGAPFSQVADVVRAPGVPAMQPQYFDLPLIQPISQGAPVAPLRASMGPVPPVPATQPQYFDIPLTEPINQGASAAHFL 720
Cdd:PHA03379 632 MFPGSPFSQVADVMRAGGVPAMQPQYFDLPLQQPISQGAPLAPLRASMGPVPPVPATQPQYFDIPLTEPINQGASAAHFL 711
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 721 PQQPMEGPLVPEQWMFPGAALSQSVRPGVAQSQYFDLPLTQPINHGAPAAHFLHQPPMEGPWVPEQWMFQGAPPSQGTDV 800
Cdd:PHA03379 712 PQQPMEGPLVPERWMFQGATLSQSVRPGVAQSQYFDLPLTQPINHGAPAAHFLHQPPMEGPWVPEQWMFQGAPPSQGTDV 791
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 801 VQHQLDALGYTLHGLNHPGVPVSPAVNQYYLSQAAFGLPIDEDESGEGSDTSEPCEALDLSIHGRPCPQAPEWPVQEEGG 880
Cdd:PHA03379 792 VQHQLDALGYVLHVLNHPGVPVSPAVNQYHVSQAAFGLPIDEDESGEGSDTSEPCEALDLSIHGRPCPQAPEWPVQGEGG 871
                        890       900       910       920       930       940
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 764011035 881 QDATEVLDLSIHGRPRPRTPEWPVQGEGGQNVTGPETRRVVVSAVVHMCQDDEFPDLQDPPDEA 944
Cdd:PHA03379 872 QDATEVLDLSIHGRPRPRTPEWPVQGEDGQNVTGAESRRVVVSALVHMCQDDEFPDLQDPPDEA 935
EBV-NA3 pfam05009
Epstein-Barr virus nuclear antigen 3 (EBNA-3); This family contains EBNA-3A, -3B, and -3C ...
139-384 1.73e-142

Epstein-Barr virus nuclear antigen 3 (EBNA-3); This family contains EBNA-3A, -3B, and -3C which are latent infection nuclear proteins important for Epstein-Barr virus (EBV)-induced B-cell immortalization and the immune response to EBV infection.


Pssm-ID: 282817  Cd Length: 254  Bit Score: 423.97  E-value: 1.73e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035  139 MAIRQAIRDRRRNPASRRDQAKWRLQTLAAGWPMGYQAYSSWMYSYTDHQTTPTFVHLQATLGCTGGRRCHVTFSAGTFK 218
Cdd:pfam05009   1 MAIRQRIQDIRRNPLSRVDQRKWRLQSLAASWPMGYRTYSLWMYSYTDHQTTPTFVHLTATLGCTGGRRCHVTFSAGTFK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035  219 LPRCTPGDRQWLYVQSSVGNIVQSCNPRYSIFFDYMAIHRSLTKIWEEVLTPDQRVSFMEFLGFLQRTDLSYIKSFVSDA 298
Cdd:pfam05009  81 LPRCTPGDQQWLYVQSSVRNIRQSCNPRYSIFFDLMAIHRSLTKIWEELLTPDNRVSFMEFLGFLQRTDLSYIKSWFSDA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035  299 LGTTSIQTPWIDDNP------STETAQAWNAGFLRGRAYGLDLLRTEGEHVEGATGETREESEDTESDGDDEDLPCIVSR 372
Cdd:pfam05009 161 LGTTKIQTPWIDANPnenpyhSTETAQAINAAFLRGQAYGIDLLRTEGEPVEGATGETREESEDTESESDDEELPCIVPR 240
                         250
                  ....*....|..
gi 764011035  373 GGPKVKRPPIFI 384
Cdd:pfam05009 241 GGPVVKRPPIFI 252
Amelin smart00817
Ameloblastin precursor (Amelin); This family consists of several mammalian Ameloblastin ...
607-738 3.10e-03

Ameloblastin precursor (Amelin); This family consists of several mammalian Ameloblastin precursor (Amelin) proteins. Matrix proteins of tooth enamel consist mainly of amelogenin but also of non-amelogenin proteins, which, although their volumetric percentage is low, have an important role in enamel mineralisation. One of the non-amelogenin proteins is ameloblastin, also known as amelin and sheathlin. Ameloblastin (AMBN) is one of the enamel sheath proteins which is though to have a role in determining the prismatic structure of growing enamel crystals.


Pssm-ID: 214832 [Multi-domain]  Cd Length: 411  Bit Score: 41.03  E-value: 3.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035   607 EAQVKQASVEVQPPQLTQVSPQQPMEGPLVPEQQMfPGAPFSQVADVVRAPgVPAMQP-----QYFDLPLIQPisQGAPv 681
Cdd:smart00817  85 ETQQYEYSLPVHPPPLPSQPSLQPQQPGLKPFLQP-TALPTNQATPQKNGP-QPPMHLgqpplQQAELPMIPP--QVAP- 159
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 764011035   682 aplrASMGPVPPVPATQPQYFDIPLTEPInqgasaAHFLPQQPMegPLVPEQWMFPG 738
Cdd:smart00817 160 ----SDKPPQTELPLYDFADPQNPLLFQI------AHLMSRGPM--PQNKQQHLYPG 204
 
Name Accession Description Interval E-value
PHA03379 PHA03379
EBNA-3A; Provisional
1-944 0e+00

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 1565.43  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035   1 MDKDRPGPPAlDDNMEEEVPSTSVVQEQVSAGDWENVLIELSDSSSEKEAEDAHLEPAQKGTKRKRVDHDAGGSAPARPM 80
Cdd:PHA03379   1 MDKDRPGLPA-PDDNIEEVPSTSGVQEQASGGDWENVLIEDSDSSSEEEAEDAHLEPPQKGKKRKRVDDDAGGSAPAQPP 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035  81 LPPQPDLPGREAILRRFPLDLRTLLQAIGAAATRIDTRAIDQFFGSQISNTEMYIMYAMAIRQAIRDRRRNPASRRDQAK 160
Cdd:PHA03379  80 CPPQLDLPGREAILGRFPLDLRKLLQAIGAAATHPDTRAIDQFFGSQISNTQRYLMYAMAIRQAIRDRRRNPASRRCQNK 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 161 WRLQTLAAGWPMGYQAYSSWMYSYTDHQTTPTFVHLQATLGCTGGRRCHVTFSAGTFKLPRCTPGDRQWLYVQSSVGNIV 240
Cdd:PHA03379 160 WRLTTLAAGWPMGYQAYSSWMYSYTDDQRTPTRIHLQATLGCEEGRRCHVTFSAGTFKPPRCSPGDRQWLYVQSCVGELV 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 241 QSCNPRYSIFFDYMAIHRSLTKIWEEVLTPDQRVSFMEFLGFLQRTDLSYIKSFVSDALGTTSIQTPWIDDNPSTETAQA 320
Cdd:PHA03379 240 QSCNPIYSIFFDYMAIHRSLTKIWEEVLTPDQRVPFMEFLGFLQRTDLIYIKSFVSEALGTTSIQTPWLDENPSTETAQA 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 321 WNAGFLRGRAYGLDLLRTEGEHVEGATGETREESEDTESDGDDEDLPCIVSRGGPKVKRPPIFIRRLHRLLLMRAGKRTE 400
Cdd:PHA03379 320 WNAGLLRGRAYGLDLLRTEGEHDEGATGETREESEDTESDGDDEELPRIVSREGTKRKRPPIFLRRLHRLLLMRAGKLTE 399
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 401 QGKEVLEKARGSTYGTPRPPVPKPRPEVPQSDETATSHGSAQVPEPPTIHLAAQGmayPLHEQHGMAPCPVAQAPPTPLP 480
Cdd:PHA03379 400 RAREALEKASEPTYGTPRPPVEKPRPEVPQSLETATSHGSAQVPEPPPVHDLEPG---PLHDQHSMAPCPVAQLPPGPLQ 476
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 481 PVSPGDQLPGVSSDGRVACAPVPAPAGPIVRPWEPSLTQAAGQAFAPVRPQHMPVEPVPVPTVALERpvypkPVRPAPPK 560
Cdd:PHA03379 477 DLEPGDQLPGVVQDGRPACAPVPAPAGPIVRPWEASLSQVPGVAFAPVMPQPMPVEPVPVPTVALER-----PVCPAPPL 551
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 561 IAMQGPGETSGIRRARERWRPAPWTPNPPRSPSQMSVRDRLARLRAEAQVKQASVEVQPPQLTQVSPQQPMEGPLVPEQQ 640
Cdd:PHA03379 552 IAMQGPGETSGIVRVRERWRPAPWTPNPPRSPSQMSVRDRLARLRAEAQPYQASVEVQPPQLTQVSPQQPMEYPLEPEQQ 631
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 641 MFPGAPFSQVADVVRAPGVPAMQPQYFDLPLIQPISQGAPVAPLRASMGPVPPVPATQPQYFDIPLTEPINQGASAAHFL 720
Cdd:PHA03379 632 MFPGSPFSQVADVMRAGGVPAMQPQYFDLPLQQPISQGAPLAPLRASMGPVPPVPATQPQYFDIPLTEPINQGASAAHFL 711
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 721 PQQPMEGPLVPEQWMFPGAALSQSVRPGVAQSQYFDLPLTQPINHGAPAAHFLHQPPMEGPWVPEQWMFQGAPPSQGTDV 800
Cdd:PHA03379 712 PQQPMEGPLVPERWMFQGATLSQSVRPGVAQSQYFDLPLTQPINHGAPAAHFLHQPPMEGPWVPEQWMFQGAPPSQGTDV 791
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 801 VQHQLDALGYTLHGLNHPGVPVSPAVNQYYLSQAAFGLPIDEDESGEGSDTSEPCEALDLSIHGRPCPQAPEWPVQEEGG 880
Cdd:PHA03379 792 VQHQLDALGYVLHVLNHPGVPVSPAVNQYHVSQAAFGLPIDEDESGEGSDTSEPCEALDLSIHGRPCPQAPEWPVQGEGG 871
                        890       900       910       920       930       940
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 764011035 881 QDATEVLDLSIHGRPRPRTPEWPVQGEGGQNVTGPETRRVVVSAVVHMCQDDEFPDLQDPPDEA 944
Cdd:PHA03379 872 QDATEVLDLSIHGRPRPRTPEWPVQGEDGQNVTGAESRRVVVSALVHMCQDDEFPDLQDPPDEA 935
EBV-NA3 pfam05009
Epstein-Barr virus nuclear antigen 3 (EBNA-3); This family contains EBNA-3A, -3B, and -3C ...
139-384 1.73e-142

Epstein-Barr virus nuclear antigen 3 (EBNA-3); This family contains EBNA-3A, -3B, and -3C which are latent infection nuclear proteins important for Epstein-Barr virus (EBV)-induced B-cell immortalization and the immune response to EBV infection.


Pssm-ID: 282817  Cd Length: 254  Bit Score: 423.97  E-value: 1.73e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035  139 MAIRQAIRDRRRNPASRRDQAKWRLQTLAAGWPMGYQAYSSWMYSYTDHQTTPTFVHLQATLGCTGGRRCHVTFSAGTFK 218
Cdd:pfam05009   1 MAIRQRIQDIRRNPLSRVDQRKWRLQSLAASWPMGYRTYSLWMYSYTDHQTTPTFVHLTATLGCTGGRRCHVTFSAGTFK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035  219 LPRCTPGDRQWLYVQSSVGNIVQSCNPRYSIFFDYMAIHRSLTKIWEEVLTPDQRVSFMEFLGFLQRTDLSYIKSFVSDA 298
Cdd:pfam05009  81 LPRCTPGDQQWLYVQSSVRNIRQSCNPRYSIFFDLMAIHRSLTKIWEELLTPDNRVSFMEFLGFLQRTDLSYIKSWFSDA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035  299 LGTTSIQTPWIDDNP------STETAQAWNAGFLRGRAYGLDLLRTEGEHVEGATGETREESEDTESDGDDEDLPCIVSR 372
Cdd:pfam05009 161 LGTTKIQTPWIDANPnenpyhSTETAQAINAAFLRGQAYGIDLLRTEGEPVEGATGETREESEDTESESDDEELPCIVPR 240
                         250
                  ....*....|..
gi 764011035  373 GGPKVKRPPIFI 384
Cdd:pfam05009 241 GGPVVKRPPIFI 252
PHA03378 PHA03378
EBNA-3B; Provisional
116-797 1.13e-22

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 104.76  E-value: 1.13e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 116 DTRAIDQFFGSQISNTEMYIMYAMAIRQAIRDRRRNPASRRDQAKWRLQTLAAGWPMGYQAYSSWMYSYTDHQTTPTFVH 195
Cdd:PHA03378 122 DLRHLGSLFLEQNLNIEEFIWMCMTVRHRCQAIREKPLPIAKQRRWKLLSPQRTWRMGYRTRHLMVNSFELGGDSVHPVL 201
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 196 LQATLGCTGGRRCHVTFSAGTFKLPRCTPGDRQWLYVQSSVGNIVQSCNPRYSIFFDYMAIHRSLTKIWEEVLTPDqRVS 275
Cdd:PHA03378 202 VTATLGCEEGERHAVTYSAGIVQPPRMSDQNQKIETAFLMARRARSLSAERYTLFFDLVSSGNTLYAIWIGLGTRN-RVA 280
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 276 FMEFLGFLQRTDLSYIKSFVSDALGTTSIQTPWIDDNP------STETAQAWNAGFLRGRAYGLDLLRTEGEHVEGATGE 349
Cdd:PHA03378 281 FVEFVGWLCKKDHTHIREWFRQCTGRPRPTKPWLRAHPvavpydDPLTSEEIDLAYARGLAMEIEAVRLPDDPIIVEDDD 360
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 350 TREESEDtESDGDDED--------LPCIVSRGGPKVKRPPIFirrlhrlLLMRAGKRTEQGKEVL----------EKARG 411
Cdd:PHA03378 361 ESEEIES-ECDPDEDKsgaealasIPQTLPDPPTVYGRPKVF-------ARKADLKSTKKCRAIVtdpsvikaieEEHRK 432
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 412 STYGtprPPVPKPRPEVPQSDETATSHGSAQVPEPPTIHLAAQGMAYPLHEQHGMAPCPVAQAPPTPLPPVSPGDQLPGV 491
Cdd:PHA03378 433 KKAA---RTEQPRATPHSQAPTVVLHRPPTQPLEGPTGPLSVQAPLEPWQPLPHPQVTPVILHQPPAQGVQAHGSMLDLL 509
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 492 SSDGRVACAPVPAPAGPIVrPWEPSLTQAAGQAFapvRPQHMPVEPVPVPTVALERPVYPKPvRPAPPKIAMQGPGETSG 571
Cdd:PHA03378 510 EKDDEDMEQRVMATLLPPS-PPQPRAGRRAPCVY---TEDLDIESDEPASTEPVHDQLLPAP-GLGPLQIQPLTSPTTSQ 584
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 572 IRRARERWRPAPW-TPNPPRSPSQMSVRdrlARLRAEAQVKQASVEVQPPQLTQVSPQQ-PMEGPLVPEQQMFPGAPFSQ 649
Cdd:PHA03378 585 LASSAPSYAQTPWpVPHPSQTPEPPTTQ---SHIPETSAPRQWPMPLRPIPMRPLRMQPiTFNVLVFPTPHQPPQVEITP 661
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 650 VADVVRAPGVPAMQPQYFDLPLIQPIS------QGAPVAPLRASMGPVPPVPATQPQYFDIPLTEPinQGASAAHFLPQQ 723
Cdd:PHA03378 662 YKPTWTQIGHIPYQPSPTGANTMLPIQwapgtmQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPP--AAAPGRARPPAA 739
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 724 ---PMEGPLVPEQWMFPGAALSQSVRPGVA---------QSQYFDLPLTQPinHGAPAAhflhQPPMEGPWVPEQWMFQG 791
Cdd:PHA03378 740 apgRARPPAAAPGRARPPAAAPGRARPPAAapgaptpqpPPQAPPAPQQRP--RGAPTP----QPPPQAGPTSMQLMPRA 813

                 ....*.
gi 764011035 792 APPSQG 797
Cdd:PHA03378 814 APGQQG 819
PHA03377 PHA03377
EBNA-3C; Provisional
98-807 1.12e-16

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 85.10  E-value: 1.12e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035   98 PLDLRTLLQAIGAAATRIDTRAIDQFFGSQISNTEMYIMYAMAIRQAIRDRRRNPASRRDQAKWR---LQTLAAGWPMGY 174
Cdd:PHA03377  105 PYSARNIRDAACEAVKQSHLQALSNLILDSGLDTQHMLCFVMAARQRLQDIRRGPLVAEGGVGWRhwlLTSPSVSWYMGY 184
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035  175 QAYSSWMYSYTDHQTTPTFVHLQATLGCTGGRRCHVTFSAGTFKLPRCTPGDRQWLYVQSSVGNIVQSCNPRYSIFFDYM 254
Cdd:PHA03377  185 RTATLRTLTPVPNRVGADSIMLTATFGCQNGARNENTFSATVWTPPLAGPREQERYAREAEVRFLRGKWQRRYRRIFDLI 264
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035  255 AIHRSLTKIWEEVL-TPDQRVSFMEFLGFLQRTDLSYIKSFVSDALGTTSIQTPWidDNPSTETA---------QAWNAG 324
Cdd:PHA03377  265 ELCGSLHHIWQNRLqTEENLLDFVRFMGVMSSCNNPAVNYWFHKTIGNFKPYYPW--NAPPNENPyharrgikeDVIQTA 342
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035  325 FLRGRAYGLDLLRTEGEHVEGATGETREESE------DTESDGDDEDLPCIVSRGGPKVKRPPIFIRRLHRLLLmragkR 398
Cdd:PHA03377  343 FRKAQRQGLSMLATGGEPRGDATSETSSDEDtgrqgsDVELESSDDELPYIDPNMEPVQQRPVMFVSRVPWRKP-----R 417
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035  399 TEQGKEVLEKARGSTYGTPRPPVPKPRPEVPQSDETATSHGSAQVPEPPtiHLAAQGMAYPLHEQHGMAPCPVAQAPPtp 478
Cdd:PHA03377  418 TLPWPTPKTHPVKRTLVKTSGRSDEAEQAQSTPERPGPSDQPSVPVEPA--HLTPVEHTTVILHQPPQSPPTVAIKPA-- 493
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035  479 lppvspgdqlPGVSSDGRVACApvpAPAGPIVRPWEPSLTQAAGQAFAPVRPQHMPVEPVPVPTVALERPVYP--KPVRP 556
Cdd:PHA03377  494 ----------PPPSRRRRGACV---VYDDDIIEVIDVETTEEEESVTQPAKPHRKVQDGFQRSGRRQKRATPPkvSPSDR 560
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035  557 APPKIAMQGPGETSGIRRARERWRPAPWTPNPPRS-PSQMSVRDRLARLRAEAQVKQASV---EVQPPQLTQVSPQQPME 632
Cdd:PHA03377  561 GPPKASPPVMAPPSTGPRVMATPSTGPRDMAPPSTgPRQQAKCKDGPPASGPHEKQPPSSaprDMAPSVVRMFLRERLLE 640
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035  633 GPLVPEQQMFPGAPFSQVADVVRAPgvPAMQpqyfdlplIQPISQGAPVAPLRA-SMGPVPPVPATQPQYFDI----PL- 706
Cdd:PHA03377  641 QSTGPKPKSFWEMRAGRDGSGIQQE--PSSR--------RQPATQSTPPRPSWLpSVFVLPSVDAGRAQPSEEshlsSMs 710
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035  707 -TEPINQGASAAHFLPQQPMEGPLVPEQWMFPGaalSQSVRPGvaqsqYFDLPLTQpinhgAPAAHFLHQPPMEGPWVPE 785
Cdd:PHA03377  711 pTQPISHEEQPRYEDPDDPLDLSLHPDQAPPPS---HQAPYSG-----HEEPQAQQ-----APYPGYWEPRPPQAPYLGY 777
                         730       740
                  ....*....|....*....|..
gi 764011035  786 QwmfqgAPPSQGTDVVQHQLDA 807
Cdd:PHA03377  778 Q-----EPQAQGVQVSSYPGYA 794
PHA03247 PHA03247
large tegument protein UL36; Provisional
467-797 2.02e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.80  E-value: 2.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035  467 APCPVAQAPPTPLPPVSPGDQLPGVSSDGRVACAPVP-----APAGPIVRPWE--PSLTQAAGQAFAPVRPQHMPVEPVP 539
Cdd:PHA03247 2613 PPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPerprdDPAPGRVSRPRraRRLGRAAQASSPPQRPRRRAARPTV 2692
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035  540 VPTVALERPVYPKPVRPAPPKIAMQGPGETSGIRRARERWRPAPWTPNPPRSPSQMSVRDRLARlRAEAQVKQASVEVQP 619
Cdd:PHA03247 2693 GSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPAR-PARPPTTAGPPAPAP 2771
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035  620 PQLTQVSPQQPMEGPlvpeqqmfPGAPFSQVADVVRAPGVPAMQPQYFDLPLIQPISQGAPVAPLRASMGPVPPVPATQP 699
Cdd:PHA03247 2772 PAAPAAGPPRRLTRP--------AVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPP 2843
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035  700 QYFdiPLTEPINQGASAAHFLPQQPMEGPLVPEQWMFPGAALSQSVRPGVAQS-QYFDLPLTQPINHGAPAAhflHQPPM 778
Cdd:PHA03247 2844 GPP--PPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRStESFALPPDQPERPPQPQA---PPPPQ 2918
                         330
                  ....*....|....*....
gi 764011035  779 EGPWVPEQWMFQGAPPSQG 797
Cdd:PHA03247 2919 PQPQPPPPPQPQPPPPPPP 2937
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
581-784 1.21e-06

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 52.35  E-value: 1.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035  581 PAPWTPNPPRSPSQ--------MSVRDRLARLRAEAQVKQAsvevQPPQLTQVSPQQPmegplvPEQQMFPGAPFSQvad 652
Cdd:pfam09770 172 APAPAPQPAAQPASlpapsrkmMSLEEVEAAMRAQAKKPAQ----QPAPAPAQPPAAP------PAQQAQQQQQFPP--- 238
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035  653 vvraPGVPAMQPQYFDLPLIQPISQGAPVAPLR--ASMGPVPPVPATQPQyfdipltepinqgasaAHFLPQQPmegplv 730
Cdd:pfam09770 239 ----QIQQQQQPQQQPQQPQQHPGQGHPVTILQrpQSPQPDPAQPSIQPQ----------------AQQFHQQP------ 292
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 764011035  731 PEQWMFPGAALSQSVRPGVAQSQYFDLPltQPINHGAPAAHFLHQPPMEGPWVP 784
Cdd:pfam09770 293 PPVPVQPTQILQNPNRLSAARVGYPQNP--QPGVQPAPAHQAHRQQGSFGRQAP 344
PHA03247 PHA03247
large tegument protein UL36; Provisional
496-699 5.46e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.71  E-value: 5.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035  496 RVACAPVPAPAGPIVRPWEPSLTQAAGQAFAPVRPQHMPVEPVPVPTVALERPVYPKPVRPAPPKIAMQGPGETSGIRRA 575
Cdd:PHA03247 2785 RPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRR 2864
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035  576 RERWRPAPWTP-NPPRSPSQMSVRDRLAR------LRAEAQVKQASVEVQPPQLTQVSPQQPMEGPLVPEQQMFPGAPFS 648
Cdd:PHA03247 2865 RPPSRSPAAKPaAPARPPVRRLARPAVSRstesfaLPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLA 2944
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 764011035  649 QVADVVRAPGVPAMQPQyfdlPLIQPISQGAPVAPLRASMGPVPPVPATQP 699
Cdd:PHA03247 2945 PTTDPAGAGEPSGAVPQ----PWLGALVPGRVAVPRFRVPQPAPSREAPAS 2991
PHA03247 PHA03247
large tegument protein UL36; Provisional
465-793 2.59e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 2.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035  465 GMAPCPVAQAPPTPLPPVSPGDQLPGVSSDGRV-------------------------------ACAPVPA------PAG 507
Cdd:PHA03247 2493 GAAPDPGGGGPPDPDAPPAPSRLAPAILPDEPVgepvhprmltwirgleelasddagdpppplpPAAPPAApdrsvpPPR 2572
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035  508 PIVRPWEPSLTQAAGQAFAPVRPQHMPVEPVPVPTvalerPVYPKPVRPAPPKIAMQGPGETSGIRRARERWRPAPWTPN 587
Cdd:PHA03247 2573 PAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGD-----PRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVP 2647
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035  588 PPRSPSQMSVRDRLARLRAEAQVKQASVEVQPPQLTQVSPQQPMEGPLV-----PEQQMFPGAPFSQVADVVRAPGVPAM 662
Cdd:PHA03247 2648 PPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTsladpPPPPPTPEPAPHALVSATPLPPGPAA 2727
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035  663 QPQYFDLPLIQPISQGAPVAPL-----------RASMGPVPPVPATQPQYFDIP-LTEPINQGASAAHFLPQQPMEGPLV 730
Cdd:PHA03247 2728 ARQASPALPAAPAPPAVPAGPAtpggparparpPTTAGPPAPAPPAAPAAGPPRrLTRPAVASLSESRESLPSPWDPADP 2807
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 764011035  731 PEQWMFPGAALSQSVRPGvaqsqyfdlPLTQPINHGAPAAHFLHQPPMEGPWVPEQWMFQGAP 793
Cdd:PHA03247 2808 PAAVLAPAAALPPAASPA---------GPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGD 2861
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
559-786 4.37e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 44.37  E-value: 4.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035  559 PKIAMQGPGETSGIRRARERWRPAPW---TPNPPRSPSQMSVRDRLARLRAEAQvkQASVEVQPPQL-TQVSPQQPMEGP 634
Cdd:pfam03154 110 PNSPSEGEGESSDGRSVNDEGSSDPKdidQDNRSTSPSIPSPQDNESDSDSSAQ--QQILQTQPPVLqAQSGAASPPSPP 187
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035  635 LVPEQQMFPGAPFSQVADVVRAPGVPAMQPQYFDLPLIQP---ISQGAPVAPLRASMGPVPPVPATQPQyfdIPLTEPIN 711
Cdd:pfam03154 188 PPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPhtlIQQTPTLHPQRLPSPHPPLQPMTQPP---PPSQVSPQ 264
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 764011035  712 QGASAAHFLPQQPMEGPLV--PEQWMFPGAALSQSVRPGVAQSQYFDLPLTQPinhGAPAAHFLHQPPMEGPWVPEQ 786
Cdd:pfam03154 265 PLPQPSLHGQMPPMPHSLQtgPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAA---PGQSQQRIHTPPSQSQLQSQQ 338
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
500-693 1.05e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.94  E-value: 1.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 500 APVPAPAGPIVRPWEPSltqAAGQAFAPVRPQHMPVEPVPVPTVALERPVYPKPVRPAPPKIAMQGPGETSGIRRARERW 579
Cdd:PRK12323 373 GPATAAAAPVAQPAPAA---AAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPA 449
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 580 R-------PAPWTPNPPRSPSQMSVRDRLARLRAEAQVKQASVEVQPPQLTQVSPQQPMEGPlvpeQQMFPGAPFSQVAD 652
Cdd:PRK12323 450 PapapaaaPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAP----AQPDAAPAGWVAES 525
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 764011035 653 VVRapgvPAMQPQYFDLPLIQPISQGAPVAPLRASMGPVPP 693
Cdd:PRK12323 526 IPD----PATADPDDAFETLAPAPAAAPAPRAAAATEPVVA 562
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
582-799 2.98e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.40  E-value: 2.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 582 APWTPNPPRSPSQMSVRDRLARLRAEAQVKQASVEVQPPQLTQVSPQQPMEGPLVPEQQMFPGAPFSQVADVVRAPGVPA 661
Cdd:PRK12323 380 APVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPA 459
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 662 mqpqyfdlPLIQPISQGAPVAPLRASMGPVPPVPATQPQyfdipltePINQGASAAHFLPQQPMEGPLVPEQWMFPGAAL 741
Cdd:PRK12323 460 --------AAARPAAAGPRPVAAAAAAAPARAAPAAAPA--------PADDDPPPWEELPPEFASPAPAQPDAAPAGWVA 523
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 764011035 742 SQSVRPGVAQSqyfdlPLTQPINHGAPAAhflhqPPMEGPWVPEQWMFQGAPPSQGTD 799
Cdd:PRK12323 524 ESIPDPATADP-----DDAFETLAPAPAA-----APAPRAAAATEPVVAPRPPRASAS 571
Amelin smart00817
Ameloblastin precursor (Amelin); This family consists of several mammalian Ameloblastin ...
607-738 3.10e-03

Ameloblastin precursor (Amelin); This family consists of several mammalian Ameloblastin precursor (Amelin) proteins. Matrix proteins of tooth enamel consist mainly of amelogenin but also of non-amelogenin proteins, which, although their volumetric percentage is low, have an important role in enamel mineralisation. One of the non-amelogenin proteins is ameloblastin, also known as amelin and sheathlin. Ameloblastin (AMBN) is one of the enamel sheath proteins which is though to have a role in determining the prismatic structure of growing enamel crystals.


Pssm-ID: 214832 [Multi-domain]  Cd Length: 411  Bit Score: 41.03  E-value: 3.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035   607 EAQVKQASVEVQPPQLTQVSPQQPMEGPLVPEQQMfPGAPFSQVADVVRAPgVPAMQP-----QYFDLPLIQPisQGAPv 681
Cdd:smart00817  85 ETQQYEYSLPVHPPPLPSQPSLQPQQPGLKPFLQP-TALPTNQATPQKNGP-QPPMHLgqpplQQAELPMIPP--QVAP- 159
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 764011035   682 aplrASMGPVPPVPATQPQYFDIPLTEPInqgasaAHFLPQQPMegPLVPEQWMFPG 738
Cdd:smart00817 160 ----SDKPPQTELPLYDFADPQNPLLFQI------AHLMSRGPM--PQNKQQHLYPG 204
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
489-719 7.46e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 40.06  E-value: 7.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 489 PGVSSDGRVACAPVPApagpivRPWEPS-LTQAAGQAFAPVRPQHMPVEPVPVPTvalERPVYP-KPVRPAPPKIAmqgp 566
Cdd:PTZ00449 549 PGETKEGEVGKKPGPA------KEHKPSkIPTLSKKPEFPKDPKHPKDPEEPKKP---KRPRSAqRPTRPKSPKLP---- 615
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 567 gETSGIRRARERwrpaPWTPNPPRSPsqmsvrdrlarlraeaqvkqasvevqPPQLTQVSPQQPmEGPLVPEQQMFPGAP 646
Cdd:PTZ00449 616 -ELLDIPKSPKR----PESPKSPKRP--------------------------PPPQRPSSPERP-EGPKIIKSPKPPKSP 663
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 764011035 647 ---------------FSQVADVVRAPGVPAMQPQYFDLPLIQ--PISQGAPVAPLRasmgPVPPVPATQPQYFDIPLTEP 709
Cdd:PTZ00449 664 kppfdpkfkekfyddYLDAAAKSKETKTTVVLDESFESILKEtlPETPGTPFTTPR----PLPPKLPRDEEFPFEPIGDP 739
                        250
                 ....*....|
gi 764011035 710 INQGASAAHF 719
Cdd:PTZ00449 740 DAEQPDDIEF 749
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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