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Conserved domains on  [gi|763908376|gb|AJQ37829|]
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Rds1p [Saccharomyces cerevisiae YJM981]

Protein Classification

Zn(II)2Cys6 transcription factor( domain architecture ID 10445721)

Zn(II)2Cys6 transcription factor domain-containing proteins form a subclass of zinc finger proteins found exclusively in fungi

Gene Ontology:  GO:0003677|GO:0008270|GO:0006351|GO:0003700
PubMed:  9290251|16959962

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Zn_clus pfam00172
Fungal Zn(2)-Cys(6) binuclear cluster domain;
14-51 1.36e-12

Fungal Zn(2)-Cys(6) binuclear cluster domain;


:

Pssm-ID: 395120 [Multi-domain]  Cd Length: 39  Bit Score: 62.32  E-value: 1.36e-12
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 763908376   14 VCLQCKKIKRKCDKLRPACSRCQQNSLQCEYEERTDLS 51
Cdd:pfam00172   2 ACDNCRKRKVKCDGKKPACSRCIKNGLECTYSRKSKKS 39
fungal_TF_MHR cd12148
fungal transcription factor regulatory middle homology region; This domain is present in the ...
 221-500 7.52e-05

fungal transcription factor regulatory middle homology region; This domain is present in the large family of fungal zinc cluster transcription factors that contain an N-terminal GAL4-like C6 zinc binuclear cluster DNA-binding domain. Examples of members of this large fungal group are the following Saccharomyces cerevisiae transcription factors, GAL4, STB5, DAL81, CAT8, RDR1, HAL9, PUT3, PPR1, ASG1, RSF2, PIP2, as well as the C-terminal domain of the Cep3, a subunit of the yeast centromere-binding factor 3. It has been suggested that this region plays a regulatory role.


:

Pssm-ID: 213391  Cd Length: 410  Bit Score: 45.90  E-value: 7.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908376 221 KKDCEILLRCFYQNIYPFYPFMDISLFESDLTSLLLQDDNNRWkistevknvrkkiETLSLLTIVMAMALMHSKLDANLL 300
Cdd:cd12148    3 REVADRLLDLYFENVHPLFPILHRPTFLRDLESLYSDPSSLSP-------------ASLALLLAVLALAALSLPDSELRG 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908376 301 SMVKENASESARklsllCHKLLCLLDVFRYPNENTFTCLLYFYVSEHLDPENPDCVLSptnlltLHHLLNLSMTLGLQYE 380
Cdd:cd12148   70 ESRRSLAERYYE-----AARQLLDLALFLPPSLETLQALLLLALYLLGTGDPSSAWLL------LGLAIRLAQSLGLHRD 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908376 381 PSKYKRFkDPEVIRQRRILWLGVQSLLFQISLAEGDAGKSNSEYMEAYLTDFEEYIEASSEYEKSSASESNVQMNDIVWn 460
Cdd:cd12148  139 PSSLPGL-SPFERELRRRLWWSLYILDRLLSLSLGRPPSISDEDIDVPLPSNEDDELSPSSSPPPPPSEEPTSLSFFIA- 216

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 763908376 461 kykfHVILSKLMSDCTSVIQHPQLFHILENIKRSEDFMAE 500
Cdd:cd12148  217 ----LIRLARILGRILRLLYSPRASSPEDSLETILELDAE 252
 
Name Accession Description Interval E-value
Zn_clus pfam00172
Fungal Zn(2)-Cys(6) binuclear cluster domain;
14-51 1.36e-12

Fungal Zn(2)-Cys(6) binuclear cluster domain;


Pssm-ID: 395120 [Multi-domain]  Cd Length: 39  Bit Score: 62.32  E-value: 1.36e-12
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 763908376   14 VCLQCKKIKRKCDKLRPACSRCQQNSLQCEYEERTDLS 51
Cdd:pfam00172   2 ACDNCRKRKVKCDGKKPACSRCIKNGLECTYSRKSKKS 39
GAL4 smart00066
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ...
 10-48 1.75e-11

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.


Pssm-ID: 214501 [Multi-domain]  Cd Length: 43  Bit Score: 59.30  E-value: 1.75e-11
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 763908376    10 RLRLVCLQCKKIKRKCDKLRPACSRCQQNSLQCEYEERT 48
Cdd:smart00066   2 RVSKACDRCRKRKIKCDGKKPPCSNCIKLGLECTYSDSK 40
GAL4 cd00067
GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like ...
 10-44 1.26e-10

GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations


Pssm-ID: 238023 [Multi-domain]  Cd Length: 36  Bit Score: 56.90  E-value: 1.26e-10
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 763908376  10 RLRLVCLQCKKIKRKCDKLRPACSRCQQNSLQCEY 44
Cdd:cd00067    1 RVRRACDRCRRRKIKCDGEKPPCSNCIKLGLECTY 35
fungal_TF_MHR cd12148
fungal transcription factor regulatory middle homology region; This domain is present in the ...
 221-500 7.52e-05

fungal transcription factor regulatory middle homology region; This domain is present in the large family of fungal zinc cluster transcription factors that contain an N-terminal GAL4-like C6 zinc binuclear cluster DNA-binding domain. Examples of members of this large fungal group are the following Saccharomyces cerevisiae transcription factors, GAL4, STB5, DAL81, CAT8, RDR1, HAL9, PUT3, PPR1, ASG1, RSF2, PIP2, as well as the C-terminal domain of the Cep3, a subunit of the yeast centromere-binding factor 3. It has been suggested that this region plays a regulatory role.


Pssm-ID: 213391  Cd Length: 410  Bit Score: 45.90  E-value: 7.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908376 221 KKDCEILLRCFYQNIYPFYPFMDISLFESDLTSLLLQDDNNRWkistevknvrkkiETLSLLTIVMAMALMHSKLDANLL 300
Cdd:cd12148    3 REVADRLLDLYFENVHPLFPILHRPTFLRDLESLYSDPSSLSP-------------ASLALLLAVLALAALSLPDSELRG 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908376 301 SMVKENASESARklsllCHKLLCLLDVFRYPNENTFTCLLYFYVSEHLDPENPDCVLSptnlltLHHLLNLSMTLGLQYE 380
Cdd:cd12148   70 ESRRSLAERYYE-----AARQLLDLALFLPPSLETLQALLLLALYLLGTGDPSSAWLL------LGLAIRLAQSLGLHRD 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908376 381 PSKYKRFkDPEVIRQRRILWLGVQSLLFQISLAEGDAGKSNSEYMEAYLTDFEEYIEASSEYEKSSASESNVQMNDIVWn 460
Cdd:cd12148  139 PSSLPGL-SPFERELRRRLWWSLYILDRLLSLSLGRPPSISDEDIDVPLPSNEDDELSPSSSPPPPPSEEPTSLSFFIA- 216

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 763908376 461 kykfHVILSKLMSDCTSVIQHPQLFHILENIKRSEDFMAE 500
Cdd:cd12148  217 ----LIRLARILGRILRLLYSPRASSPEDSLETILELDAE 252
 
Name Accession Description Interval E-value
Zn_clus pfam00172
Fungal Zn(2)-Cys(6) binuclear cluster domain;
14-51 1.36e-12

Fungal Zn(2)-Cys(6) binuclear cluster domain;


Pssm-ID: 395120 [Multi-domain]  Cd Length: 39  Bit Score: 62.32  E-value: 1.36e-12
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 763908376   14 VCLQCKKIKRKCDKLRPACSRCQQNSLQCEYEERTDLS 51
Cdd:pfam00172   2 ACDNCRKRKVKCDGKKPACSRCIKNGLECTYSRKSKKS 39
GAL4 smart00066
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ...
 10-48 1.75e-11

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.


Pssm-ID: 214501 [Multi-domain]  Cd Length: 43  Bit Score: 59.30  E-value: 1.75e-11
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 763908376    10 RLRLVCLQCKKIKRKCDKLRPACSRCQQNSLQCEYEERT 48
Cdd:smart00066   2 RVSKACDRCRKRKIKCDGKKPPCSNCIKLGLECTYSDSK 40
GAL4 cd00067
GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like ...
 10-44 1.26e-10

GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations


Pssm-ID: 238023 [Multi-domain]  Cd Length: 36  Bit Score: 56.90  E-value: 1.26e-10
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 763908376  10 RLRLVCLQCKKIKRKCDKLRPACSRCQQNSLQCEY 44
Cdd:cd00067    1 RVRRACDRCRRRKIKCDGEKPPCSNCIKLGLECTY 35
fungal_TF_MHR cd12148
fungal transcription factor regulatory middle homology region; This domain is present in the ...
 221-500 7.52e-05

fungal transcription factor regulatory middle homology region; This domain is present in the large family of fungal zinc cluster transcription factors that contain an N-terminal GAL4-like C6 zinc binuclear cluster DNA-binding domain. Examples of members of this large fungal group are the following Saccharomyces cerevisiae transcription factors, GAL4, STB5, DAL81, CAT8, RDR1, HAL9, PUT3, PPR1, ASG1, RSF2, PIP2, as well as the C-terminal domain of the Cep3, a subunit of the yeast centromere-binding factor 3. It has been suggested that this region plays a regulatory role.


Pssm-ID: 213391  Cd Length: 410  Bit Score: 45.90  E-value: 7.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908376 221 KKDCEILLRCFYQNIYPFYPFMDISLFESDLTSLLLQDDNNRWkistevknvrkkiETLSLLTIVMAMALMHSKLDANLL 300
Cdd:cd12148    3 REVADRLLDLYFENVHPLFPILHRPTFLRDLESLYSDPSSLSP-------------ASLALLLAVLALAALSLPDSELRG 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908376 301 SMVKENASESARklsllCHKLLCLLDVFRYPNENTFTCLLYFYVSEHLDPENPDCVLSptnlltLHHLLNLSMTLGLQYE 380
Cdd:cd12148   70 ESRRSLAERYYE-----AARQLLDLALFLPPSLETLQALLLLALYLLGTGDPSSAWLL------LGLAIRLAQSLGLHRD 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908376 381 PSKYKRFkDPEVIRQRRILWLGVQSLLFQISLAEGDAGKSNSEYMEAYLTDFEEYIEASSEYEKSSASESNVQMNDIVWn 460
Cdd:cd12148  139 PSSLPGL-SPFERELRRRLWWSLYILDRLLSLSLGRPPSISDEDIDVPLPSNEDDELSPSSSPPPPPSEEPTSLSFFIA- 216

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 763908376 461 kykfHVILSKLMSDCTSVIQHPQLFHILENIKRSEDFMAE 500
Cdd:cd12148  217 ----LIRLARILGRILRLLYSPRASSPEDSLETILELDAE 252
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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