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Conserved domains on  [gi|763908367|gb|AJQ37820|]
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Cdc39p [Saccharomyces cerevisiae YJM981]

Protein Classification

CDC39 family protein( domain architecture ID 11473807)

CDC39 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CDC39 COG5103
Cell division control protein, negative regulator of transcription [Cell division and ...
 1-2108 0e+00

Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription];


:

Pssm-ID: 227434 [Multi-domain]  Cd Length: 2005  Bit Score: 2783.00  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367    1 MLSATYRDLNTASNLETSKEKQAAQIVIAQISLLFTTLNNDNFESVEREIRHILDRSSVDIYIKVWERLLTLSSRDILQA 80
Cdd:COG5103     1 MKSQEQQTPETREKSSSTSESKIESIVKAQILFLLSTLREDQYDTKLEQIRQLINKNAPRVYHHFLRRLIQGNSYRIFGT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367   81 GKFLLQENLLHRLLLEFAKDLPKKSTDLIELLKERTFNNQEFQKQTGITLSLFIDLFDKSANKDIIESLDRSSQINDFKT 160
Cdd:COG5103    81 GKSSDGLATYKLLLDELKSLTKKRFSDAISGSDSEVFEDFHFQFSIGLTTSLLKNTFQSLLNQLSDPTQQQSIDKNDLDL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367  161 IKMNHTNYLRNFFLQTTPETLESNLRDLLHSLEGESLNDLLALLLSEILSPGSQNLQNDPTRSWLTPPMVLDATNRGNVI 240
Cdd:COG5103   161 LREGTTDYDRKIFRQEIKDVLEKSDPLTALFGPREVDRSFLDDALQRILRPRREVVPEDVARAILFMADFPDRGEWNLVA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367  241 ARSISSLQANQINWNRVFNLMSTKYFLSAPLMPTTASLSCLFAALHDGPVIDEFFSCDWKVIFKLDLAIQLHKWSVQNGC 320
Cdd:COG5103   241 IVGAMKSNLEEINWRDVYSCFLDVNFSIWTLEPLYVIIDCWFYISGIITVPYEFFFKRWKNERAQILFIRLHIESDEKRT 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367  321 FDLLNAEGTRKVSETIPNTKQSLLYLLSIASLNLELFLQREELSDGPMLAYFQECFfedFNYAPEYLILALVKEMKRFVL 400
Cdd:COG5103   321 FDYSNVFFTRIVSIEDSRGHRFKNYMGYESNLNCVELFQCIMLGSLPLIEYIARLF---LNKSPEWCAAGLGFVQPKFSP 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367  401 LIENRTVIDEILITLLIQVHNKSPSSFKDVISTITDDSKIVDAAKIIINSDDAPIANFLKSLLDTGRLDTVINKLP--FN 478
Cdd:COG5103   398 LAWNPVQESRIFEELLMGFANGAPNSFVFVVLFRTHPEMMLQKSRLVLAKDGIPVSRLLDIFLEHKMLPLVSNLLPpeFC 477

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367  479 EAFKILPCARQIG----WEGFDTFLKTKVSPSNVDVVLESLEVQTKMTDTNTPFRSLKTFDLFAFHSLIEVLNKCPLDVL 554
Cdd:COG5103   478 FDIIVLSSARDHLnlgiWLSNNLTTRKDADGLNVFVVSLVQYLDSKVSKHKEPEKQKEESVMFPLNTVIEILGTFTKAVE 557

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367  555 Q-LQRFESLEFSLLIAFPRLINFGFGHDEAILANGDIAGINNDIEKEMQNYLQKMYSGELAIKDVIELLRRLRDSDLPRD 633
Cdd:COG5103   558 QyIRILKPETVVVLNEFPRLIPHGLRRDSIVAATNTTRSKEIDIEEEASSYIQQIYNSQRGIESSINQLKEFLRSENPRD 637

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367  634 QEVFTCITHAVIAESTFFQDYPLDALATTSVLFGSMILFQLLRGFVLDVAFRIIMRFAKEPPESKMFKFAVQAIYAFRIR 713
Cdd:COG5103   638 KELFSCIFHALLEEYGFFYDYPLSALALTAVLFGSLIKFRLLPKPYLRVAIRYIKGSLKHPENSKMFSFGFQALEVFQEK 717

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367  714 LAEYPQYCKDLLRdVPALKSQAQVYQSIVEAATLANAPKERSRPVQEMIPLKFFAVDEVSCQINQEGAPKDVVEKVLFVL 793
Cdd:COG5103   718 LPSYPSYCSEVLE-IPTLNNRILIYKSIVEMDSNENTEVEKANPTHPMLPLEDFVRLIVKCDANNEGRATEVVKSILFAI 796

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367  794 NNVTLANLNNKVDELKKSLTPNYFSWFSTYLVTQRAKTEPNYHDLYSKVIVAMGSGLLHQFMVNVTLRQLFVLLSTKDEQ 873
Cdd:COG5103   797 NNLLDLNRNDKIHRLKEALTPGYVGWFSIYMVTQRSTAEENCRRLYGKVVERLGSKDLYLRFSRKTLEFLKMLLDYRCES 876

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367  874 AIDKKHLKNLASWLGCITLALNKPIKHKNIAFREMLIEAYKENRLEIVVPFVTKILQRASESKIFKPPNPWTVGILKLLI 953
Cdd:COG5103   877 PSEKKVLKNLGSWLGRITLAKNKPITSEQFDFKKFLVESVECRRILFVVPFVSKFLRQASCSIIFKPPNPWVMGILKLLS 956

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367  954 ELNEKANWKLSLTFEVEVLLKSFNLTTKSLKPSNFINTPEVIEtlsgalgsiTLEQQQTEQQRQIILMQQHQQQMLIYQQ 1033
Cdd:COG5103   957 ELHSCAPRVLRLKFEIEGLLRHLNVELVPIKPSKSLGNHLVLK---------SRLEKELPEDVLNAKFPDGTDYLAQYII 1027

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1034 RQQqqqqrqqqqqhhiSANTIADQQAAFGGEgsishdnPFnnllgstifvthPDLKRVFQMALAKSVREILLEVVEKSSG 1113
Cdd:COG5103  1028 EDS-------------SQITVTDLVARHVGS-------PK------------PAIKNLTQLALDLSVREICGAVVEKSCG 1075

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1114 IAVVTTTKIILKDFATEVDESKLKTAAIIMVRHLAQSLARATSIEPLKEGIRSTMQSLAPNLMSLSSSPAEELDTAINEN 1193
Cdd:COG5103  1076 IAIQTTMALFKKDFAMEVEKSMLYVAARNMVVNLAKFLALVTAQEPLKACISGNVRSYAMKLCSVLDFSAEKVDKIAMEN 1155

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1194 IGIALVLIEKASMDKSTQDLADQLMQAIAIRRYHKERRADQPFITQNTNPYSLSLPEPLGLKNTGVTPQQFRVYEEFgkn 1273
Cdd:COG5103  1156 QDVACRLIERAGVSKVSESISAEIEHMIVERVRHRKTTPNLPFVDPAAANLSLNLPSSLELSIGKATPQQFSLYEDF--- 1232

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1274 ipnlDVIPFAGLPAHAPPMTQNVGLTQPQQQQAQMPTQILTSEQIRAQQQQQQLQKSRLNQPSQSAQppgVNVPNPQGGI 1353
Cdd:COG5103  1233 ----DRLSLSTIMGHIEKIAINAIDTDSADSTDALNNNLNNTVENEANQTALEYQENLLIIKAQLVQ---LSKKIPYSSK 1305

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1354 AAVQSDLEQNqrvlvhlmdilvsQIKENAtknnlaelgdqNQIKTIIFQILTFIAKSaqkDQLALKVSQAVVNSLFATSE 1433
Cdd:COG5103  1306 KNVIADEEHG-------------LLKEGK-----------NQFETVFRRILESIASS---DDKDLECIQLCRYILGHLSK 1358

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1434 SPLCREVLSLLLEKLCSLSLVARKDVVWWLVYALDSRKFNVPVIRSLLEVNLIDATELDNVLVTAMKNKMENSTEFAMKL 1513
Cdd:COG5103  1359 SPSKEEVLSRCLEKICKISFKTQKEVLGWLIYSNDPRKFNIPLIGSLIEHNLINVVEYDQALSRKIPLADGNVTDFAIAL 1438

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1514 IQNTVLSDDPILMRMDFIKTLEHLASSEDENVKKFIKEFEDTKIMPVRKGTKTTRTEKLYLVFTEWVKLLQRVENNDVIT 1593
Cdd:COG5103  1439 LASLVTAEVPICTVYDFICTLEMLAGSSDPKVKDFFQKISNTMMHIVAKGNKQQLNDQIIIVFSEWVELLRNCRFNDTVP 1518

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1594 TVFIKQLVEKGVISDTDNLLTFVKSSLELSVSSFKESDPTDEVFIAIDALGSLIIKLLILQGFKDDTRRDYINAIFSVIV 1673
Cdd:COG5103  1519 EMFLPQLMERGDYSASLDIRSFFKVSLEHFIRAFHERIPTAYCYLKIDALPSLIKNRLYEEGSTEGTVSVLFRKIIKDIL 1598

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1674 LVFAKDHSQEGTTFNERPYFRLFSNILYEWATIrthnfvRISDSStrqELIEFDSVFYNTFSgylhALQPFAFPGFSFAW 1753
Cdd:COG5103  1599 FVFAEAHRKRAEFVHNYLFFRLFSRILIETLDV------IDEDTS---CFVNNRSVVYSIFE----ALQPSRFPGFTFAW 1665

                        1770      1780      1790      1800      1810      1820      1830      1840
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1754 VTLLSHRMLLPIMLRLPNKIGWEKLMLLIIDLFKFLDqyTSKHAVSDAVSVVYKGTLRVILGISNDMPSFLIENHYELMN 1833
Cdd:COG5103  1666 LELLSHKFLLPKVLLVNNDKINDLFSEGLMSFLKFLD--LSEEGVVLVMEALYCGFLRTILVYLHDFPGFLITQIYQLFR 1743

                        1850      1860      1870      1880      1890      1900      1910      1920
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1834 NLPPTYFQLKNVILCAIPKNMTVPNPYDVDLNMEDIPACKELPEVFFDPVIDLHSLKKPVDnyLRIPSNSLLRTILSAIY 1913
Cdd:COG5103  1744 RNPLECVQLRNMMLSAYPSDLTYPCPFAQGLKVQEYPHIKNFPNQFRDRIVPLEGQNSFFD--LEACLRSALQNRTSVKV 1821

                        1930      1940      1950      1960      1970      1980      1990      2000
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1914 KDTYDIKKgVGYDFLSVDSKLIRAIVLHVGIEAgieykRTSSNAVFNTKSSYYTLLFNLIQNGSIEMKYQIILSIVEQLR 1993
Cdd:COG5103  1822 TDLYIGKN-TPLWVYLIDNLNEMDAVSHTVVES-----IKFMIERFMHKSEILTMLWIRMRAGGPPKRYFLLTAILAQLR 1895

                        2010      2020      2030      2040      2050      2060      2070      2080
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1994 YPNIHTYWFSFVLMNMFKSDEWNDQKLEVQEIILRNFLKRIIVNKPHTWGVSVFFTQLINNNDINLLDLPFVQSVPEIKL 2073
Cdd:COG5103  1896 YPEIHTYDFSRVFLKSFKSHGYNPQKLLIKEQMTTVLLERIICNRPHPWGLLITFTELLKNEDYNFWKHPYIKRNDEICR 1975

                        2090      2100      2110
                  ....*....|....*....|....*....|....*
gi 763908367 2074 ILQQLVKYSKKYTTSEqddqsATINRRQTPLQSNA 2108
Cdd:COG5103  1976 LFDSLHEHVMAPSSAN-----NVSTEEATELMGQV 2005
 
Name Accession Description Interval E-value
CDC39 COG5103
Cell division control protein, negative regulator of transcription [Cell division and ...
 1-2108 0e+00

Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription];


Pssm-ID: 227434 [Multi-domain]  Cd Length: 2005  Bit Score: 2783.00  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367    1 MLSATYRDLNTASNLETSKEKQAAQIVIAQISLLFTTLNNDNFESVEREIRHILDRSSVDIYIKVWERLLTLSSRDILQA 80
Cdd:COG5103     1 MKSQEQQTPETREKSSSTSESKIESIVKAQILFLLSTLREDQYDTKLEQIRQLINKNAPRVYHHFLRRLIQGNSYRIFGT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367   81 GKFLLQENLLHRLLLEFAKDLPKKSTDLIELLKERTFNNQEFQKQTGITLSLFIDLFDKSANKDIIESLDRSSQINDFKT 160
Cdd:COG5103    81 GKSSDGLATYKLLLDELKSLTKKRFSDAISGSDSEVFEDFHFQFSIGLTTSLLKNTFQSLLNQLSDPTQQQSIDKNDLDL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367  161 IKMNHTNYLRNFFLQTTPETLESNLRDLLHSLEGESLNDLLALLLSEILSPGSQNLQNDPTRSWLTPPMVLDATNRGNVI 240
Cdd:COG5103   161 LREGTTDYDRKIFRQEIKDVLEKSDPLTALFGPREVDRSFLDDALQRILRPRREVVPEDVARAILFMADFPDRGEWNLVA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367  241 ARSISSLQANQINWNRVFNLMSTKYFLSAPLMPTTASLSCLFAALHDGPVIDEFFSCDWKVIFKLDLAIQLHKWSVQNGC 320
Cdd:COG5103   241 IVGAMKSNLEEINWRDVYSCFLDVNFSIWTLEPLYVIIDCWFYISGIITVPYEFFFKRWKNERAQILFIRLHIESDEKRT 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367  321 FDLLNAEGTRKVSETIPNTKQSLLYLLSIASLNLELFLQREELSDGPMLAYFQECFfedFNYAPEYLILALVKEMKRFVL 400
Cdd:COG5103   321 FDYSNVFFTRIVSIEDSRGHRFKNYMGYESNLNCVELFQCIMLGSLPLIEYIARLF---LNKSPEWCAAGLGFVQPKFSP 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367  401 LIENRTVIDEILITLLIQVHNKSPSSFKDVISTITDDSKIVDAAKIIINSDDAPIANFLKSLLDTGRLDTVINKLP--FN 478
Cdd:COG5103   398 LAWNPVQESRIFEELLMGFANGAPNSFVFVVLFRTHPEMMLQKSRLVLAKDGIPVSRLLDIFLEHKMLPLVSNLLPpeFC 477

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367  479 EAFKILPCARQIG----WEGFDTFLKTKVSPSNVDVVLESLEVQTKMTDTNTPFRSLKTFDLFAFHSLIEVLNKCPLDVL 554
Cdd:COG5103   478 FDIIVLSSARDHLnlgiWLSNNLTTRKDADGLNVFVVSLVQYLDSKVSKHKEPEKQKEESVMFPLNTVIEILGTFTKAVE 557

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367  555 Q-LQRFESLEFSLLIAFPRLINFGFGHDEAILANGDIAGINNDIEKEMQNYLQKMYSGELAIKDVIELLRRLRDSDLPRD 633
Cdd:COG5103   558 QyIRILKPETVVVLNEFPRLIPHGLRRDSIVAATNTTRSKEIDIEEEASSYIQQIYNSQRGIESSINQLKEFLRSENPRD 637

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367  634 QEVFTCITHAVIAESTFFQDYPLDALATTSVLFGSMILFQLLRGFVLDVAFRIIMRFAKEPPESKMFKFAVQAIYAFRIR 713
Cdd:COG5103   638 KELFSCIFHALLEEYGFFYDYPLSALALTAVLFGSLIKFRLLPKPYLRVAIRYIKGSLKHPENSKMFSFGFQALEVFQEK 717

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367  714 LAEYPQYCKDLLRdVPALKSQAQVYQSIVEAATLANAPKERSRPVQEMIPLKFFAVDEVSCQINQEGAPKDVVEKVLFVL 793
Cdd:COG5103   718 LPSYPSYCSEVLE-IPTLNNRILIYKSIVEMDSNENTEVEKANPTHPMLPLEDFVRLIVKCDANNEGRATEVVKSILFAI 796

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367  794 NNVTLANLNNKVDELKKSLTPNYFSWFSTYLVTQRAKTEPNYHDLYSKVIVAMGSGLLHQFMVNVTLRQLFVLLSTKDEQ 873
Cdd:COG5103   797 NNLLDLNRNDKIHRLKEALTPGYVGWFSIYMVTQRSTAEENCRRLYGKVVERLGSKDLYLRFSRKTLEFLKMLLDYRCES 876

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367  874 AIDKKHLKNLASWLGCITLALNKPIKHKNIAFREMLIEAYKENRLEIVVPFVTKILQRASESKIFKPPNPWTVGILKLLI 953
Cdd:COG5103   877 PSEKKVLKNLGSWLGRITLAKNKPITSEQFDFKKFLVESVECRRILFVVPFVSKFLRQASCSIIFKPPNPWVMGILKLLS 956

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367  954 ELNEKANWKLSLTFEVEVLLKSFNLTTKSLKPSNFINTPEVIEtlsgalgsiTLEQQQTEQQRQIILMQQHQQQMLIYQQ 1033
Cdd:COG5103   957 ELHSCAPRVLRLKFEIEGLLRHLNVELVPIKPSKSLGNHLVLK---------SRLEKELPEDVLNAKFPDGTDYLAQYII 1027

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1034 RQQqqqqrqqqqqhhiSANTIADQQAAFGGEgsishdnPFnnllgstifvthPDLKRVFQMALAKSVREILLEVVEKSSG 1113
Cdd:COG5103  1028 EDS-------------SQITVTDLVARHVGS-------PK------------PAIKNLTQLALDLSVREICGAVVEKSCG 1075

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1114 IAVVTTTKIILKDFATEVDESKLKTAAIIMVRHLAQSLARATSIEPLKEGIRSTMQSLAPNLMSLSSSPAEELDTAINEN 1193
Cdd:COG5103  1076 IAIQTTMALFKKDFAMEVEKSMLYVAARNMVVNLAKFLALVTAQEPLKACISGNVRSYAMKLCSVLDFSAEKVDKIAMEN 1155

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1194 IGIALVLIEKASMDKSTQDLADQLMQAIAIRRYHKERRADQPFITQNTNPYSLSLPEPLGLKNTGVTPQQFRVYEEFgkn 1273
Cdd:COG5103  1156 QDVACRLIERAGVSKVSESISAEIEHMIVERVRHRKTTPNLPFVDPAAANLSLNLPSSLELSIGKATPQQFSLYEDF--- 1232

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1274 ipnlDVIPFAGLPAHAPPMTQNVGLTQPQQQQAQMPTQILTSEQIRAQQQQQQLQKSRLNQPSQSAQppgVNVPNPQGGI 1353
Cdd:COG5103  1233 ----DRLSLSTIMGHIEKIAINAIDTDSADSTDALNNNLNNTVENEANQTALEYQENLLIIKAQLVQ---LSKKIPYSSK 1305

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1354 AAVQSDLEQNqrvlvhlmdilvsQIKENAtknnlaelgdqNQIKTIIFQILTFIAKSaqkDQLALKVSQAVVNSLFATSE 1433
Cdd:COG5103  1306 KNVIADEEHG-------------LLKEGK-----------NQFETVFRRILESIASS---DDKDLECIQLCRYILGHLSK 1358

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1434 SPLCREVLSLLLEKLCSLSLVARKDVVWWLVYALDSRKFNVPVIRSLLEVNLIDATELDNVLVTAMKNKMENSTEFAMKL 1513
Cdd:COG5103  1359 SPSKEEVLSRCLEKICKISFKTQKEVLGWLIYSNDPRKFNIPLIGSLIEHNLINVVEYDQALSRKIPLADGNVTDFAIAL 1438

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1514 IQNTVLSDDPILMRMDFIKTLEHLASSEDENVKKFIKEFEDTKIMPVRKGTKTTRTEKLYLVFTEWVKLLQRVENNDVIT 1593
Cdd:COG5103  1439 LASLVTAEVPICTVYDFICTLEMLAGSSDPKVKDFFQKISNTMMHIVAKGNKQQLNDQIIIVFSEWVELLRNCRFNDTVP 1518

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1594 TVFIKQLVEKGVISDTDNLLTFVKSSLELSVSSFKESDPTDEVFIAIDALGSLIIKLLILQGFKDDTRRDYINAIFSVIV 1673
Cdd:COG5103  1519 EMFLPQLMERGDYSASLDIRSFFKVSLEHFIRAFHERIPTAYCYLKIDALPSLIKNRLYEEGSTEGTVSVLFRKIIKDIL 1598

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1674 LVFAKDHSQEGTTFNERPYFRLFSNILYEWATIrthnfvRISDSStrqELIEFDSVFYNTFSgylhALQPFAFPGFSFAW 1753
Cdd:COG5103  1599 FVFAEAHRKRAEFVHNYLFFRLFSRILIETLDV------IDEDTS---CFVNNRSVVYSIFE----ALQPSRFPGFTFAW 1665

                        1770      1780      1790      1800      1810      1820      1830      1840
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1754 VTLLSHRMLLPIMLRLPNKIGWEKLMLLIIDLFKFLDqyTSKHAVSDAVSVVYKGTLRVILGISNDMPSFLIENHYELMN 1833
Cdd:COG5103  1666 LELLSHKFLLPKVLLVNNDKINDLFSEGLMSFLKFLD--LSEEGVVLVMEALYCGFLRTILVYLHDFPGFLITQIYQLFR 1743

                        1850      1860      1870      1880      1890      1900      1910      1920
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1834 NLPPTYFQLKNVILCAIPKNMTVPNPYDVDLNMEDIPACKELPEVFFDPVIDLHSLKKPVDnyLRIPSNSLLRTILSAIY 1913
Cdd:COG5103  1744 RNPLECVQLRNMMLSAYPSDLTYPCPFAQGLKVQEYPHIKNFPNQFRDRIVPLEGQNSFFD--LEACLRSALQNRTSVKV 1821

                        1930      1940      1950      1960      1970      1980      1990      2000
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1914 KDTYDIKKgVGYDFLSVDSKLIRAIVLHVGIEAgieykRTSSNAVFNTKSSYYTLLFNLIQNGSIEMKYQIILSIVEQLR 1993
Cdd:COG5103  1822 TDLYIGKN-TPLWVYLIDNLNEMDAVSHTVVES-----IKFMIERFMHKSEILTMLWIRMRAGGPPKRYFLLTAILAQLR 1895

                        2010      2020      2030      2040      2050      2060      2070      2080
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1994 YPNIHTYWFSFVLMNMFKSDEWNDQKLEVQEIILRNFLKRIIVNKPHTWGVSVFFTQLINNNDINLLDLPFVQSVPEIKL 2073
Cdd:COG5103  1896 YPEIHTYDFSRVFLKSFKSHGYNPQKLLIKEQMTTVLLERIICNRPHPWGLLITFTELLKNEDYNFWKHPYIKRNDEICR 1975

                        2090      2100      2110
                  ....*....|....*....|....*....|....*
gi 763908367 2074 ILQQLVKYSKKYTTSEqddqsATINRRQTPLQSNA 2108
Cdd:COG5103  1976 LFDSLHEHVMAPSSAN-----NVSTEEATELMGQV 2005
Not1 pfam04054
CCR4-Not complex component, Not1; The Ccr4-Not complex is a global regulator of transcription ...
 1714-2075 2.60e-170

CCR4-Not complex component, Not1; The Ccr4-Not complex is a global regulator of transcription that affects genes positively and negatively and is thought to regulate transcription factor TFIID.


Pssm-ID: 427680  Cd Length: 365  Bit Score: 524.77  E-value: 2.60e-170
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367  1714 ISDSSTRQELIEFDSVFYNTFSGYLHALQPFAFPGFSFAWVTLLSHRMLLPIMLRLPNKIGWEKLMLLIIDLFKFLDQYT 1793
Cdd:pfam04054    2 CELNSVEELLEEEDQEFLLAFASALHSLQPIYFPGFTFAWLSLISHRMFLPKLLRLPDQKGWPLYTKLLIDLLKFLGEYL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367  1794 SKHAVSDAVSVVYKGTLRVILGISNDMPSFLIENHYELMNNLPPTYFQLKNVILCAIPKNMTVPNPYDVDLNMEDIPACK 1873
Cdd:pfam04054   82 KKAELSDVIKVLYKGTLRILLVLLHDFPEFLAENHYQLCNAIPPHCIQLRNIILSAFPRNMKLPDPFTPGLKVDRLPEIR 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367  1874 ELPEVFFDPVIDLH--SLKKPVDNYLR-IPSNSLLRTILSAIYKDTYDIkKGVGYDFLSVDSKLIRAIVLHVGIEAGIEY 1950
Cdd:pfam04054  162 QAPKILYDPVADLQeaGLKKPVDNYLRsIPSESLLATILHALYLSEYKE-TGFGFVPISVNVKLINALVLYVGIHAVAEA 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367  1951 KRTSSNAVFNTKSSYYTLLFNLIQNGSIEMKYQIILSIVEQLRYPNIHTYWFSFVLMNMFKSDEWNDQKLEVQEIILRNF 2030
Cdd:pfam04054  241 QKKGSSAVFNPKSPHVALLSNLIHELDPEGRYYLLSAIANQLRYPNSHTHYFSCVLLHLFGSDMSDPEETEIQEQITRVL 320

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 763908367  2031 LKRIIVNKPHTWGVSVFFTQLINNNDINLLDLPFVQSVPEIKLIL 2075
Cdd:pfam04054  321 LERLIVNRPHPWGLLITFIELLKNPKYNFWELPFIKAAPEIEELF 365
NOT1_connector cd20710
Connector domain of NOT1; This NOT1 connector domain is one of several catalytically inactive ...
 1364-1553 3.99e-48

Connector domain of NOT1; This NOT1 connector domain is one of several catalytically inactive subunits of the multisubunit CCR4-NOT complex assembly that plays a central role in post-translational gene regulation in eukaryotes. CCR4-NOT contains the catalytic center formed by two deadenylase subunits CCR4 and CAF1, and the conserved core complex which contains a minimum of four catalytically inactive subunits, NOT1, NOT2, NOT3 and CAF40/NOT9. NOT1 is the largest subunit which functions as a central scaffold for complex assembly in human orthologs. The Chaetomium thermophilum NOT1 connector domain consists of five alpha-helical hairpin repeats of the HEAT type that structurally resemble MIF4G domains, and hence is also called the MIF4G-C domain. However, NOT1 MIF4G-C does not interact with DEAD-box helicases such as DDX6 like MIF4G does. Structural conservation of this domain suggests an important role but its function is as yet unknown.


Pssm-ID: 411008 [Multi-domain]  Cd Length: 202  Bit Score: 171.29  E-value: 3.99e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1364 QRVLVHLMDILVSQIKENATKNN---LAELGDQNQIKTIIFQILTFIAKSAQKDQLALKVSQAVVNSLFATSESPLCREV 1440
Cdd:cd20710     4 PDQLLERFDKLLAELERLLAEAPeehISDLPPDHEIRSLLRQILQLIISSEQRDELALALAQKIVQLLYESSESQLAREV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1441 LSLLLEKLCSLSLVARKDVVWWLVYALDSRKFNVPVIRSLLEVNLIDATELDNVLVTAMKNKM-ENSTEFAMKLIQNTVL 1519
Cdd:cd20710    84 LVALLEKLCDLSPKVAKEVTSWLIYSDDERKFNVPVTVALIRSGLLNLAEYDAQLAKLIENGRnPAALEFAAQLLRELLL 163

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 763908367 1520 SDDPILMRMDFIKTLEHLA-----SSEDENVKKFIKEFE 1553
Cdd:cd20710   164 DDRPVALRADFANTLEALAklaqeSPSPEGLQQLLEKLR 202
 
Name Accession Description Interval E-value
CDC39 COG5103
Cell division control protein, negative regulator of transcription [Cell division and ...
 1-2108 0e+00

Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription];


Pssm-ID: 227434 [Multi-domain]  Cd Length: 2005  Bit Score: 2783.00  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367    1 MLSATYRDLNTASNLETSKEKQAAQIVIAQISLLFTTLNNDNFESVEREIRHILDRSSVDIYIKVWERLLTLSSRDILQA 80
Cdd:COG5103     1 MKSQEQQTPETREKSSSTSESKIESIVKAQILFLLSTLREDQYDTKLEQIRQLINKNAPRVYHHFLRRLIQGNSYRIFGT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367   81 GKFLLQENLLHRLLLEFAKDLPKKSTDLIELLKERTFNNQEFQKQTGITLSLFIDLFDKSANKDIIESLDRSSQINDFKT 160
Cdd:COG5103    81 GKSSDGLATYKLLLDELKSLTKKRFSDAISGSDSEVFEDFHFQFSIGLTTSLLKNTFQSLLNQLSDPTQQQSIDKNDLDL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367  161 IKMNHTNYLRNFFLQTTPETLESNLRDLLHSLEGESLNDLLALLLSEILSPGSQNLQNDPTRSWLTPPMVLDATNRGNVI 240
Cdd:COG5103   161 LREGTTDYDRKIFRQEIKDVLEKSDPLTALFGPREVDRSFLDDALQRILRPRREVVPEDVARAILFMADFPDRGEWNLVA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367  241 ARSISSLQANQINWNRVFNLMSTKYFLSAPLMPTTASLSCLFAALHDGPVIDEFFSCDWKVIFKLDLAIQLHKWSVQNGC 320
Cdd:COG5103   241 IVGAMKSNLEEINWRDVYSCFLDVNFSIWTLEPLYVIIDCWFYISGIITVPYEFFFKRWKNERAQILFIRLHIESDEKRT 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367  321 FDLLNAEGTRKVSETIPNTKQSLLYLLSIASLNLELFLQREELSDGPMLAYFQECFfedFNYAPEYLILALVKEMKRFVL 400
Cdd:COG5103   321 FDYSNVFFTRIVSIEDSRGHRFKNYMGYESNLNCVELFQCIMLGSLPLIEYIARLF---LNKSPEWCAAGLGFVQPKFSP 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367  401 LIENRTVIDEILITLLIQVHNKSPSSFKDVISTITDDSKIVDAAKIIINSDDAPIANFLKSLLDTGRLDTVINKLP--FN 478
Cdd:COG5103   398 LAWNPVQESRIFEELLMGFANGAPNSFVFVVLFRTHPEMMLQKSRLVLAKDGIPVSRLLDIFLEHKMLPLVSNLLPpeFC 477

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367  479 EAFKILPCARQIG----WEGFDTFLKTKVSPSNVDVVLESLEVQTKMTDTNTPFRSLKTFDLFAFHSLIEVLNKCPLDVL 554
Cdd:COG5103   478 FDIIVLSSARDHLnlgiWLSNNLTTRKDADGLNVFVVSLVQYLDSKVSKHKEPEKQKEESVMFPLNTVIEILGTFTKAVE 557

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367  555 Q-LQRFESLEFSLLIAFPRLINFGFGHDEAILANGDIAGINNDIEKEMQNYLQKMYSGELAIKDVIELLRRLRDSDLPRD 633
Cdd:COG5103   558 QyIRILKPETVVVLNEFPRLIPHGLRRDSIVAATNTTRSKEIDIEEEASSYIQQIYNSQRGIESSINQLKEFLRSENPRD 637

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367  634 QEVFTCITHAVIAESTFFQDYPLDALATTSVLFGSMILFQLLRGFVLDVAFRIIMRFAKEPPESKMFKFAVQAIYAFRIR 713
Cdd:COG5103   638 KELFSCIFHALLEEYGFFYDYPLSALALTAVLFGSLIKFRLLPKPYLRVAIRYIKGSLKHPENSKMFSFGFQALEVFQEK 717

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367  714 LAEYPQYCKDLLRdVPALKSQAQVYQSIVEAATLANAPKERSRPVQEMIPLKFFAVDEVSCQINQEGAPKDVVEKVLFVL 793
Cdd:COG5103   718 LPSYPSYCSEVLE-IPTLNNRILIYKSIVEMDSNENTEVEKANPTHPMLPLEDFVRLIVKCDANNEGRATEVVKSILFAI 796

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367  794 NNVTLANLNNKVDELKKSLTPNYFSWFSTYLVTQRAKTEPNYHDLYSKVIVAMGSGLLHQFMVNVTLRQLFVLLSTKDEQ 873
Cdd:COG5103   797 NNLLDLNRNDKIHRLKEALTPGYVGWFSIYMVTQRSTAEENCRRLYGKVVERLGSKDLYLRFSRKTLEFLKMLLDYRCES 876

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367  874 AIDKKHLKNLASWLGCITLALNKPIKHKNIAFREMLIEAYKENRLEIVVPFVTKILQRASESKIFKPPNPWTVGILKLLI 953
Cdd:COG5103   877 PSEKKVLKNLGSWLGRITLAKNKPITSEQFDFKKFLVESVECRRILFVVPFVSKFLRQASCSIIFKPPNPWVMGILKLLS 956

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367  954 ELNEKANWKLSLTFEVEVLLKSFNLTTKSLKPSNFINTPEVIEtlsgalgsiTLEQQQTEQQRQIILMQQHQQQMLIYQQ 1033
Cdd:COG5103   957 ELHSCAPRVLRLKFEIEGLLRHLNVELVPIKPSKSLGNHLVLK---------SRLEKELPEDVLNAKFPDGTDYLAQYII 1027

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1034 RQQqqqqrqqqqqhhiSANTIADQQAAFGGEgsishdnPFnnllgstifvthPDLKRVFQMALAKSVREILLEVVEKSSG 1113
Cdd:COG5103  1028 EDS-------------SQITVTDLVARHVGS-------PK------------PAIKNLTQLALDLSVREICGAVVEKSCG 1075

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1114 IAVVTTTKIILKDFATEVDESKLKTAAIIMVRHLAQSLARATSIEPLKEGIRSTMQSLAPNLMSLSSSPAEELDTAINEN 1193
Cdd:COG5103  1076 IAIQTTMALFKKDFAMEVEKSMLYVAARNMVVNLAKFLALVTAQEPLKACISGNVRSYAMKLCSVLDFSAEKVDKIAMEN 1155

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1194 IGIALVLIEKASMDKSTQDLADQLMQAIAIRRYHKERRADQPFITQNTNPYSLSLPEPLGLKNTGVTPQQFRVYEEFgkn 1273
Cdd:COG5103  1156 QDVACRLIERAGVSKVSESISAEIEHMIVERVRHRKTTPNLPFVDPAAANLSLNLPSSLELSIGKATPQQFSLYEDF--- 1232

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1274 ipnlDVIPFAGLPAHAPPMTQNVGLTQPQQQQAQMPTQILTSEQIRAQQQQQQLQKSRLNQPSQSAQppgVNVPNPQGGI 1353
Cdd:COG5103  1233 ----DRLSLSTIMGHIEKIAINAIDTDSADSTDALNNNLNNTVENEANQTALEYQENLLIIKAQLVQ---LSKKIPYSSK 1305

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1354 AAVQSDLEQNqrvlvhlmdilvsQIKENAtknnlaelgdqNQIKTIIFQILTFIAKSaqkDQLALKVSQAVVNSLFATSE 1433
Cdd:COG5103  1306 KNVIADEEHG-------------LLKEGK-----------NQFETVFRRILESIASS---DDKDLECIQLCRYILGHLSK 1358

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1434 SPLCREVLSLLLEKLCSLSLVARKDVVWWLVYALDSRKFNVPVIRSLLEVNLIDATELDNVLVTAMKNKMENSTEFAMKL 1513
Cdd:COG5103  1359 SPSKEEVLSRCLEKICKISFKTQKEVLGWLIYSNDPRKFNIPLIGSLIEHNLINVVEYDQALSRKIPLADGNVTDFAIAL 1438

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1514 IQNTVLSDDPILMRMDFIKTLEHLASSEDENVKKFIKEFEDTKIMPVRKGTKTTRTEKLYLVFTEWVKLLQRVENNDVIT 1593
Cdd:COG5103  1439 LASLVTAEVPICTVYDFICTLEMLAGSSDPKVKDFFQKISNTMMHIVAKGNKQQLNDQIIIVFSEWVELLRNCRFNDTVP 1518

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1594 TVFIKQLVEKGVISDTDNLLTFVKSSLELSVSSFKESDPTDEVFIAIDALGSLIIKLLILQGFKDDTRRDYINAIFSVIV 1673
Cdd:COG5103  1519 EMFLPQLMERGDYSASLDIRSFFKVSLEHFIRAFHERIPTAYCYLKIDALPSLIKNRLYEEGSTEGTVSVLFRKIIKDIL 1598

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1674 LVFAKDHSQEGTTFNERPYFRLFSNILYEWATIrthnfvRISDSStrqELIEFDSVFYNTFSgylhALQPFAFPGFSFAW 1753
Cdd:COG5103  1599 FVFAEAHRKRAEFVHNYLFFRLFSRILIETLDV------IDEDTS---CFVNNRSVVYSIFE----ALQPSRFPGFTFAW 1665

                        1770      1780      1790      1800      1810      1820      1830      1840
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1754 VTLLSHRMLLPIMLRLPNKIGWEKLMLLIIDLFKFLDqyTSKHAVSDAVSVVYKGTLRVILGISNDMPSFLIENHYELMN 1833
Cdd:COG5103  1666 LELLSHKFLLPKVLLVNNDKINDLFSEGLMSFLKFLD--LSEEGVVLVMEALYCGFLRTILVYLHDFPGFLITQIYQLFR 1743

                        1850      1860      1870      1880      1890      1900      1910      1920
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1834 NLPPTYFQLKNVILCAIPKNMTVPNPYDVDLNMEDIPACKELPEVFFDPVIDLHSLKKPVDnyLRIPSNSLLRTILSAIY 1913
Cdd:COG5103  1744 RNPLECVQLRNMMLSAYPSDLTYPCPFAQGLKVQEYPHIKNFPNQFRDRIVPLEGQNSFFD--LEACLRSALQNRTSVKV 1821

                        1930      1940      1950      1960      1970      1980      1990      2000
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1914 KDTYDIKKgVGYDFLSVDSKLIRAIVLHVGIEAgieykRTSSNAVFNTKSSYYTLLFNLIQNGSIEMKYQIILSIVEQLR 1993
Cdd:COG5103  1822 TDLYIGKN-TPLWVYLIDNLNEMDAVSHTVVES-----IKFMIERFMHKSEILTMLWIRMRAGGPPKRYFLLTAILAQLR 1895

                        2010      2020      2030      2040      2050      2060      2070      2080
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1994 YPNIHTYWFSFVLMNMFKSDEWNDQKLEVQEIILRNFLKRIIVNKPHTWGVSVFFTQLINNNDINLLDLPFVQSVPEIKL 2073
Cdd:COG5103  1896 YPEIHTYDFSRVFLKSFKSHGYNPQKLLIKEQMTTVLLERIICNRPHPWGLLITFTELLKNEDYNFWKHPYIKRNDEICR 1975

                        2090      2100      2110
                  ....*....|....*....|....*....|....*
gi 763908367 2074 ILQQLVKYSKKYTTSEqddqsATINRRQTPLQSNA 2108
Cdd:COG5103  1976 LFDSLHEHVMAPSSAN-----NVSTEEATELMGQV 2005
Not1 pfam04054
CCR4-Not complex component, Not1; The Ccr4-Not complex is a global regulator of transcription ...
 1714-2075 2.60e-170

CCR4-Not complex component, Not1; The Ccr4-Not complex is a global regulator of transcription that affects genes positively and negatively and is thought to regulate transcription factor TFIID.


Pssm-ID: 427680  Cd Length: 365  Bit Score: 524.77  E-value: 2.60e-170
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367  1714 ISDSSTRQELIEFDSVFYNTFSGYLHALQPFAFPGFSFAWVTLLSHRMLLPIMLRLPNKIGWEKLMLLIIDLFKFLDQYT 1793
Cdd:pfam04054    2 CELNSVEELLEEEDQEFLLAFASALHSLQPIYFPGFTFAWLSLISHRMFLPKLLRLPDQKGWPLYTKLLIDLLKFLGEYL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367  1794 SKHAVSDAVSVVYKGTLRVILGISNDMPSFLIENHYELMNNLPPTYFQLKNVILCAIPKNMTVPNPYDVDLNMEDIPACK 1873
Cdd:pfam04054   82 KKAELSDVIKVLYKGTLRILLVLLHDFPEFLAENHYQLCNAIPPHCIQLRNIILSAFPRNMKLPDPFTPGLKVDRLPEIR 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367  1874 ELPEVFFDPVIDLH--SLKKPVDNYLR-IPSNSLLRTILSAIYKDTYDIkKGVGYDFLSVDSKLIRAIVLHVGIEAGIEY 1950
Cdd:pfam04054  162 QAPKILYDPVADLQeaGLKKPVDNYLRsIPSESLLATILHALYLSEYKE-TGFGFVPISVNVKLINALVLYVGIHAVAEA 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367  1951 KRTSSNAVFNTKSSYYTLLFNLIQNGSIEMKYQIILSIVEQLRYPNIHTYWFSFVLMNMFKSDEWNDQKLEVQEIILRNF 2030
Cdd:pfam04054  241 QKKGSSAVFNPKSPHVALLSNLIHELDPEGRYYLLSAIANQLRYPNSHTHYFSCVLLHLFGSDMSDPEETEIQEQITRVL 320

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 763908367  2031 LKRIIVNKPHTWGVSVFFTQLINNNDINLLDLPFVQSVPEIKLIL 2075
Cdd:pfam04054  321 LERLIVNRPHPWGLLITFIELLKNPKYNFWELPFIKAAPEIEELF 365
CNOT1_CAF1_bind pfam16415
CCR4-NOT transcription complex subunit 1 CAF1-binding domain; This is the CAF1-binding domain ...
 777-999 1.15e-109

CCR4-NOT transcription complex subunit 1 CAF1-binding domain; This is the CAF1-binding domain of CCR4-NOT transcription complex. It adopts a MIF4G (middle portion of eIF4G) fold.


Pssm-ID: 465111  Cd Length: 225  Bit Score: 348.34  E-value: 1.15e-109
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367   777 NQEGAPKDVVEKVLFVLNNVTLANLNNKVDELKKSLTPNYFSWFSTYLVTQRAKTEPNYHDLYSKVIVAMGSGLLHQFMV 856
Cdd:pfam16415    1 EQEEPPEEVQDKILFIVNNLSEDNLESKLKELKELLEEEYYPWFAQYLVVKRASIEPNFHKLYLKLLDKLNSPLLYEEVL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367   857 NVTLRQLFVLLSTKD--EQAIDKKHLKNLASWLGCITLALNKPIKHKNIAFREMLIEAYKENRLEIVVPFVTKILQRASE 934
Cdd:pfam16415   81 NETYRNIKVLLNSEKtlTSSSERSLLKNLGSWLGSITLARNKPILHKNIAFKELLLEAYDKGRLIVVIPFVCKVLEQAKK 160

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 763908367   935 SKIFKPPNPWTVGILKLLIELNEKANWKLSLTFEVEVLLKSFNLTTKSLKPSNFINTPEVIETLS 999
Cdd:pfam16415  161 SKVFKPPNPWTMGILKLLVELYHLADLKLNLKFEIEVLCKNLNLDIKDIEPSTLLRDRDRLEELS 225
CNOT1_HEAT_N pfam16419
CCR4-NOT transcription complex subunit 1 HEAT repeat; This domain is a HEAT repeat found in ...
 169-392 2.68e-102

CCR4-NOT transcription complex subunit 1 HEAT repeat; This domain is a HEAT repeat found in fungal CCR4-NOT transcription complex subunit 1 at the N-terminus of PF16418.


Pssm-ID: 406747  Cd Length: 224  Bit Score: 327.28  E-value: 2.68e-102
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367   169 LRNFFLQTTPETLESNLRDLLHSLEGESLNDLLALLLSEILSPGSQNLQNDPTRSWLTPPMVLDATNRGNVIARSISSLQ 248
Cdd:pfam16419    1 FQELLLETTPETLLPNLPDLLYSLKGEELNDMIALLLAEILSPGSQNLQNNPGNSWLTPNSVPEATARGAQLSAAIKSLD 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367   249 ANQINWNRVFNLMSTKYFLSAPLMPTTASLSCLFAALHDGPVIDEFFSCDWKVIFKLDLAIQLHKWSVQNGCFDLLNAEG 328
Cdd:pfam16419   81 KDQINWNRVFNLMSTKYFLSTAVQPTLASLSQFLSSLDKGGLIDQFLSCDWNISFKLNLLYLLHKWSPQQGCFDLLSSKN 160

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 763908367   329 TRKVSETIPNTKQSLLYLLSIASLNLELFLQREELSDGPMLAYFQECFFEDFNYAPEYLILALV 392
Cdd:pfam16419  161 LKKVSDIIPNSKNSLLYLISIAKLELELFLLRDELQENPLLSYFQECFFEDYNVVPEYLALALI 224
DUF3819 pfam12842
CCR4-Not complex, Not1 subunit, domain of unknown function DUF3819; This is an uncharacterized ...
 1086-1227 5.38e-59

CCR4-Not complex, Not1 subunit, domain of unknown function DUF3819; This is an uncharacterized domain that is found on the CCR4-Not complex component Not1. Not1 is a global regulator of transcription that affects genes positively and negatively and is thought to regulate transcription factor TFIID.


Pssm-ID: 463726  Cd Length: 143  Bit Score: 199.67  E-value: 5.38e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367  1086 PDLKRVFQMALAKSVREILLEVVEKSSGIAVVTTTKIILKDFATEVDESKLKTAAIIMVRHLAQSLARATSIEPLKEGIR 1165
Cdd:pfam12842    1 PDLKRLVQAAIERAIREIISPVVERSVTIAVITTEELVLKDFATEPDENKMRKAAHLMVRNLAGSLALVTCKEPLRESIS 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 763908367  1166 STMQSLAPN-LMSLSSSPAEELDTAINENIGIALVLIEKASMDKSTQDLADQLMQAIAIRRYH 1227
Cdd:pfam12842   81 NNLRSLLSNlLPNVNEQPEQAIQLAANDNLDLACAFIEKAAMEKAIPEIDERLAPAYELRRRH 143
NOT1_connector cd20710
Connector domain of NOT1; This NOT1 connector domain is one of several catalytically inactive ...
 1364-1553 3.99e-48

Connector domain of NOT1; This NOT1 connector domain is one of several catalytically inactive subunits of the multisubunit CCR4-NOT complex assembly that plays a central role in post-translational gene regulation in eukaryotes. CCR4-NOT contains the catalytic center formed by two deadenylase subunits CCR4 and CAF1, and the conserved core complex which contains a minimum of four catalytically inactive subunits, NOT1, NOT2, NOT3 and CAF40/NOT9. NOT1 is the largest subunit which functions as a central scaffold for complex assembly in human orthologs. The Chaetomium thermophilum NOT1 connector domain consists of five alpha-helical hairpin repeats of the HEAT type that structurally resemble MIF4G domains, and hence is also called the MIF4G-C domain. However, NOT1 MIF4G-C does not interact with DEAD-box helicases such as DDX6 like MIF4G does. Structural conservation of this domain suggests an important role but its function is as yet unknown.


Pssm-ID: 411008 [Multi-domain]  Cd Length: 202  Bit Score: 171.29  E-value: 3.99e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1364 QRVLVHLMDILVSQIKENATKNN---LAELGDQNQIKTIIFQILTFIAKSAQKDQLALKVSQAVVNSLFATSESPLCREV 1440
Cdd:cd20710     4 PDQLLERFDKLLAELERLLAEAPeehISDLPPDHEIRSLLRQILQLIISSEQRDELALALAQKIVQLLYESSESQLAREV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367 1441 LSLLLEKLCSLSLVARKDVVWWLVYALDSRKFNVPVIRSLLEVNLIDATELDNVLVTAMKNKM-ENSTEFAMKLIQNTVL 1519
Cdd:cd20710    84 LVALLEKLCDLSPKVAKEVTSWLIYSDDERKFNVPVTVALIRSGLLNLAEYDAQLAKLIENGRnPAALEFAAQLLRELLL 163

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 763908367 1520 SDDPILMRMDFIKTLEHLA-----SSEDENVKKFIKEFE 1553
Cdd:cd20710   164 DDRPVALRADFANTLEALAklaqeSPSPEGLQQLLEKLR 202
CNOT1_TTP_bind pfam16417
CCR4-NOT transcription complex subunit 1 TTP binding domain; This is the TTP binding domain of ...
 592-744 3.27e-38

CCR4-NOT transcription complex subunit 1 TTP binding domain; This is the TTP binding domain of CCR4-NOT transcription complex subunit 1. It adopts a MIF4G (middle portion of eIF4G) fold.


Pssm-ID: 465112  Cd Length: 183  Bit Score: 141.97  E-value: 3.27e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367   592 GINNDIEKEMQNYLQKMYSGELAIKDVIELLRRLRDSDLPRDQEVFTCITHAVIAESTFFQDYPLDALATTSVLFGSMIL 671
Cdd:pfam16417   22 QFSQEVEKEANSYFQRLYNGEISIEEFIEMLKQFKSSKNKREQEVFACMITNLFDEYKFFPQYPDKELLITGQLFGSIIE 101

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 763908367   672 FQLLRGFVLDVAFRIIMRFAKEPPESKMFKFAVQAIYAFRIRLAEYPQYCkDLLRDVPALKsqaQVYQSIVEA 744
Cdd:pfam16417  102 HGLVSYKALGIALRYVLEALRKPPGSKMFEFGIKALEQFKSRLKEWPQYC-QHLDSIPHLR---EFPPDLVEY 170
CNOT1_HEAT pfam16418
CCR4-NOT transcription complex subunit 1 HEAT repeat; This domain is a HEAT repeat found in ...
 405-547 6.20e-17

CCR4-NOT transcription complex subunit 1 HEAT repeat; This domain is a HEAT repeat found in CCR4-NOT transcription complex subunit 1.


Pssm-ID: 465113  Cd Length: 146  Bit Score: 79.57  E-value: 6.20e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763908367   405 RTVIDEiLITLLIQVHNKSPSsfkdVISTITDDSKIVDAAKII--INSDDAPIANFLKSLLDTGRLDTVINKLPFNEAFK 482
Cdd:pfam16418    1 QELIDE-LFPLFLQGHPNSDL----VLHSLWEVDPQLLLKRLVdyYARDPLNLSRILDVAQELKILDELLNLLPFNFALD 75

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 763908367   483 ILPCARQIGWEGFDTFLKTKVS---PSNVDVVLESLEVQTKMTDT---NTPFRSLKTFDLFAFHSLIEVLN 547
Cdd:pfam16418   76 LAALASRRGYLDLEKWLQDKLKehgEPFAQALLDFLEIKAKLELEvqaNQPEPSSVPLSVETVHTLLKVLQ 146
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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