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Conserved domains on  [gi|760448349|ref|XP_011401243|]
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Conserved oligomeric Golgi complex subunit 5 [Auxenochlorella protothecoides]

Protein Classification

COG5 family protein( domain architecture ID 367728)

COG5 family protein similar to Arabidopsis thaliana conserved oligomeric Golgi complex subunit 5 (COG5) which is a component of the conserved oligomeric Golgi complex (COG), and is required for normal Golgi function

Gene Ontology:  GO:0015031
SCOP:  4004137

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5 super family cl46990
Golgi transport complex subunit 5; The COG complex, the peripheral membrane oligomeric protein ...
 25-149 6.12e-12

Golgi transport complex subunit 5; The COG complex, the peripheral membrane oligomeric protein complex involved in intra-Golgi protein trafficking, consists of eight subunits arranged in two lobes bridged by Cog1. Cog5 is in the smaller, B lobe, bound in with Cog6-8, and is itself bound to Cog1 as well as, strongly, to Cog7.


The actual alignment was detected with superfamily member pfam10392:

Pssm-ID: 192566  Cd Length: 132  Bit Score: 63.48  E-value: 6.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 760448349   25 PFLADDFDAATFASQAIVSGGGSAPAH------MRELREGIDRLEAGIREHLNTHQDSLLASAGSLGSVEADLDRTSLSI 98
Cdd:pfam10392   2 AFLDPDFDPKSFANALLLATNNNDDTPldlstpLKRLNYDIQELDRRIRTLITSNHLELLSHLSSIKSASSILSTLKSSL 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 760448349   99 AALRSLASRVRADVAGPAARVRALTHQARGLQSTIDLLQHVTYRLKLVSQL 149
Cdd:pfam10392  82 EYLSASYERLKSDVLEPYERALKLQSALKRLHQTTDLLRALLRFLHLSRQL 132
 
Name Accession Description Interval E-value
COG5 pfam10392
Golgi transport complex subunit 5; The COG complex, the peripheral membrane oligomeric protein ...
 25-149 6.12e-12

Golgi transport complex subunit 5; The COG complex, the peripheral membrane oligomeric protein complex involved in intra-Golgi protein trafficking, consists of eight subunits arranged in two lobes bridged by Cog1. Cog5 is in the smaller, B lobe, bound in with Cog6-8, and is itself bound to Cog1 as well as, strongly, to Cog7.


Pssm-ID: 192566  Cd Length: 132  Bit Score: 63.48  E-value: 6.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 760448349   25 PFLADDFDAATFASQAIVSGGGSAPAH------MRELREGIDRLEAGIREHLNTHQDSLLASAGSLGSVEADLDRTSLSI 98
Cdd:pfam10392   2 AFLDPDFDPKSFANALLLATNNNDDTPldlstpLKRLNYDIQELDRRIRTLITSNHLELLSHLSSIKSASSILSTLKSSL 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 760448349   99 AALRSLASRVRADVAGPAARVRALTHQARGLQSTIDLLQHVTYRLKLVSQL 149
Cdd:pfam10392  82 EYLSASYERLKSDVLEPYERALKLQSALKRLHQTTDLLRALLRFLHLSRQL 132
 
Name Accession Description Interval E-value
COG5 pfam10392
Golgi transport complex subunit 5; The COG complex, the peripheral membrane oligomeric protein ...
 25-149 6.12e-12

Golgi transport complex subunit 5; The COG complex, the peripheral membrane oligomeric protein complex involved in intra-Golgi protein trafficking, consists of eight subunits arranged in two lobes bridged by Cog1. Cog5 is in the smaller, B lobe, bound in with Cog6-8, and is itself bound to Cog1 as well as, strongly, to Cog7.


Pssm-ID: 192566  Cd Length: 132  Bit Score: 63.48  E-value: 6.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 760448349   25 PFLADDFDAATFASQAIVSGGGSAPAH------MRELREGIDRLEAGIREHLNTHQDSLLASAGSLGSVEADLDRTSLSI 98
Cdd:pfam10392   2 AFLDPDFDPKSFANALLLATNNNDDTPldlstpLKRLNYDIQELDRRIRTLITSNHLELLSHLSSIKSASSILSTLKSSL 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 760448349   99 AALRSLASRVRADVAGPAARVRALTHQARGLQSTIDLLQHVTYRLKLVSQL 149
Cdd:pfam10392  82 EYLSASYERLKSDVLEPYERALKLQSALKRLHQTTDLLRALLRFLHLSRQL 132
COG2 pfam06148
COG (conserved oligomeric Golgi) complex component, COG2; The COG complex comprises eight ...
 26-137 6.69e-04

COG (conserved oligomeric Golgi) complex component, COG2; The COG complex comprises eight proteins COG1-8. The COG complex plays critical roles in Golgi structure and function. The proposed function of the complex is to mediate the initial physical contact between transport vesicles and their membrane targets. A comparable role in tethering vesicles has been suggested for at least six additional large multisubunit complexes, including the exocyst, a complex that mediates trafficking to the plasma membrane. COG2 structure reveals a six-helix bundle with few conserved surface features but a general resemblance to recently determined crystal structures of four different exocyst subunits. These bundles inCOG2 may act as platforms for interaction with other trafficing proteins including SNAREs (soluble N-ethylmaleimide factor attachment protein receptors) and Rabs.


Pssm-ID: 399271  Cd Length: 133  Bit Score: 40.33  E-value: 6.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 760448349   26 FLADDFDAATFASQaiVSGGGSAPAHMRELREGIDRLEAGIREHLNTHQDSLLASAGSLGSVEADLDRTSLSIAALRSLA 105
Cdd:pfam06148   8 FLAPDFDPDAFVSE--LRHHVPLESLRRDLRAYLKLLRRELLELVNEDYADFVSLSTNLVGLDEKLNEVEVPLLALRKEV 85

                          90       100       110
                  ....*....|....*....|....*....|..
gi 760448349  106 SRVRADVAGPAARVRALTHQARGLQSTIDLLQ 137
Cdd:pfam06148  86 ESVRDELEARLEEVEQKLEERKALREKRESLK 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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