|
Name |
Accession |
Description |
Interval |
E-value |
| recB |
PRK10876 |
exonuclease V subunit beta; Provisional |
18-1212 |
0e+00 |
|
exonuclease V subunit beta; Provisional
Pssm-ID: 236784 [Multi-domain] Cd Length: 1181 Bit Score: 1540.31 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 18 QPTPLEPMTFPLHGARLIEASAGTGKTFTIAGLYLRLLLGHGSAETRHRvPLTVDQILVVTFTEAATAELRDRIRARIHD 97
Cdd:PRK10876 5 VAETLDPLRLPLQGERLIEASAGTGKTFTIAALYLRLLLGLGGSAAFPR-PLTVEEILVVTFTEAATEELRGRIRSNIHE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 98 ARIAFARGQSSDPVIQPLLNEFDDHKQAAEILLQAERQMDEAAVYTIHGFCQRMLTQNAFESGSRFNNEFVTDESHLKAQ 177
Cdd:PRK10876 84 LRIACLREETDNPLYQRLLAEIDDKAQAAQWLLLAERQMDEAAIFTIHGFCQRMLNLNAFESGMLFEQQLIEDESLLRYQ 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 178 VVADYWRRNFYPLPFTLAGEIRQLWSSPSALLSDISNYLTG-APLSLSVPAMKGSLADLHTENLKKIDELKAQWRESQDD 256
Cdd:PRK10876 164 ACADFWRRHCYPLPREIARVVFQEWKGPEALLKDISRYLQGeAPVIKAPPPDDETLASRHEQIVARIDAVKQQWREAVGE 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 257 FFTLISDSDINKRSYTKKSLPTWLEAVNAWAATETTGYDYPDKLEKFAQNVLLEKTPKGSAPQHAVFEAIETFLANPISL 336
Cdd:PRK10876 244 LDALIESSGVDRRSYNSKNLPKWLEKISAWAEEETNSYQLPKELEKFSQRFLLEKTKKGETPQHPLFEAIDQLLAEPLSL 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 337 KAPLLAHAIEHCRVMLANAKNQKQWLSFDDLLTQLSASIDTDESELLAARIRTLYPVAMIDEFQDTDPLQYSIFSRIYLN 416
Cdd:PRK10876 324 RDLVITRALAEIRETVAQEKRRRGELGFDDLLSRLDSALQSEGGEALAAAIRTRYPVAMIDEFQDTDPQQYRIFRRIYRH 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 417 DPECGLFMIGDPKQAIYGFRGADIFTYIKARNQVSAHYTLGTNWRSSADMVQAVNQVFALPDSPFIYdSDIPFLPVKYSP 496
Cdd:PRK10876 404 QPETALLLIGDPKQAIYAFRGADIFTYMKARSEVSAHYTLDTNWRSAPGMVNSVNKLFSQTDDPFLF-REIPFIPVKAAG 482
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 497 NAEKRIWTMGGQKQPALTYWLQEADdkPLPKGEYLTRMAEATASQIQTILTQAQQGQACLVNGEKQKAVQAGDIAVLVRT 576
Cdd:PRK10876 483 KNQALRFVVKGETQPAMKFWLMEGE--GVGVGDYQQTMAQQCAAQIRDWLQAGQRGEALLMNGDDSRPVRASDITVLVRS 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 577 GSEGRMVKQALADQGIASVYLSNRDSVFTSSVAQDLQRLLQAVLTPENDRALRASLASELFALDAASLDALNNDEVVWEN 656
Cdd:PRK10876 561 RQEAALIRDALTLLAIPSVYLSNRDSVFETLEAQEMLWLLQAVLAPERERTLRSALATSMMGLDALDIDALNNDERAWDA 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 657 AVNEFKEYRKLWVQRGVLPMLRAVISKRHIAERLLeegASsqgENGERVLTDLMHIGELLQQASNELDSDHGLLRWLAQS 736
Cdd:PRK10876 641 LVEEFDGYRQIWRKRGVLPMLRALMSARNIAENLL---AT---AGGERRLTDILHIGELLQEASSQLDSEHALVRWLAQQ 714
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 737 ISDAEnglGGSDDQIQRLESERNLVQIVTIHKSKGLEYDLVFLPFVFSYREASEAKYYDAANDRTVLDITGNDASMKQAD 816
Cdd:PRK10876 715 ILEPD---SQASSQQLRLESDKHLVQIVTIHKSKGLEYPLVWLPFITNFRVQDQAFYHDRHSFEAVLDLNAAEESVALAE 791
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 817 KERLAEDLRLIYVALTRAVYACFIGASPLRNGRSTKE-PTGVHRSAIGYLIQNGQEGGINDLHQGLtkQQDELDCVVVAD 895
Cdd:PRK10876 792 EERLAEDLRLLYVALTRSVWHCSLGVAPLVRRRRKKKgETDLHQSALGYLLQKGEPGDAAGLRACL--EALCDDDIALQT 869
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 896 PPQQLEDKYVAPQEEIHDLSAKELQNPIDRNWRITSYSGLVKQGSHHAEhdatiEIT-GFDIDSSEEQDEADlvEPERSI 974
Cdd:PRK10876 870 AQETDNQPWQPQDASLAELSARTLQRLLQDNWRVTSYSGLQQHGHSIAQ-----DLLpRLDVDAAGEGSVVE--EPQLTP 942
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 975 FTFPRGARPGTFLHSLFEEIEFTQPATTEentqiilglMESEQL-----DEEWLPILQQLIDTVLVTPLDGKSLLLNQKA 1049
Cdd:PRK10876 943 HTFPRGASPGTFLHSLFEDLDFTQPVDPE---------WLQEQLelqgfEEQWEPVLTQWITAVLQTPLNETGVSLSQLS 1013
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 1050 PSQRLVEMEFLLPIE-VLSAPALNRVIQRHDPLSAKAGDLGFQTVQGMLKGFIDLVFEHQGKYYVLDWKSNHLGDDVTHY 1128
Cdd:PRK10876 1014 ARDKQVEMQFYLPIDqPLTASQLDALIRQYDPLSAGCPPLDFMQVRGMLKGFIDLVFRWQGRYYLLDYKSNWLGEDSSAY 1093
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 1129 HGEALKSAMADHRYDLQYQIYALALHRFLRSRLANYQYEQHFGGVYYLFLRGMDGQ-SDHGIFAAKPTLDFLREMDRLID 1207
Cdd:PRK10876 1094 TQEAMAQAMQAHRYDLQYQLYTLALHRYLRHRLADYDYQRHFGGVIYLFLRGVDKEhPGQGIFTTRPNAALIDGLDELFA 1173
|
....*
gi 758852163 1208 GQVLE 1212
Cdd:PRK10876 1174 GETLE 1178
|
|
| recB |
TIGR00609 |
exodeoxyribonuclease V, beta subunit; The RecBCD holoenzyme is a multifunctional nuclease with ... |
22-1206 |
0e+00 |
|
exodeoxyribonuclease V, beta subunit; The RecBCD holoenzyme is a multifunctional nuclease with potent ATP-dependent exodeoxyribonuclease activity. Ejection of RecD, as occurs at chi recombinational hotspots, cripples exonuclease activity in favor of recombinagenic helicase activity. All proteins in this family for which functions are known are DNA-DNA helicases that are used as part of an exonuclease-helicase complex (made up of RecBCD homologs) that function to generate substrates for the initiation of recombination and recombinational repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273172 [Multi-domain] Cd Length: 1087 Bit Score: 1013.12 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 22 LEPMTFPLHGARLIEASAGTGKTFTIAGLYLRLLLGHGsaetrhrvPLTVDQILVVTFTEAATAELRDRIRARIHDARIA 101
Cdd:TIGR00609 1 LDPLTIPLNGTFLIEASAGTGKTFTIAQLYLRLLLEGG--------PLTVEEILVVTFTNAATEELKTRIRGRIHQALRA 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 102 FARGQSSDPVIQPLLNEFDDHK--QAAEILLQAERQMDEAAVYTIHGFCQRMLTQNAFESGSRFNNEFVTDESHLKAQVV 179
Cdd:TIGR00609 73 LKAALTSQELPEPLKEAIQDEKvkQAITRLRNALATMDEAAIYTIHGFCQRMLEQHAFESDEIFDVELIEDESLLLAEIT 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 180 ADYWRRNFYPLPFTLAGEIRQLWSSPSALLSDISNYLTGaPLSLSVPAMkgsladlhTENLKKIDELKAQWRESQDDFft 259
Cdd:TIGR00609 153 KDFWRRNFYNLPFDIAQIVLKTKKSPQAVLTQILADLLL-QSYLAFPSP--------PLDLEQLIKWHEQIYKDLDKL-- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 260 lisdsdinkrsytkkslptwleavnawaatettgydypdklekfaqnvllektpkgsapQHAVFEAIET---FLANPISL 336
Cdd:TIGR00609 222 -----------------------------------------------------------DHAVFEEIDKlnaERNNLFCL 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 337 KAPLLAHAIEHCRVMLANAKNQKQWLSFDDLLTQLSASIDTDESELLAARIRTLYPVAMIDEFQDTDPLQYSIFSRIYLN 416
Cdd:TIGR00609 243 KDRVFLTLLKEVQEELKKEKKRRREIGFDDLLSRLETALKSAEGEKLAQAIREQYPIALIDEFQDTDPQQYRIFSKLFIA 322
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 417 DPECGLFMIGDPKQAIYGFRGADIFTYIKARNQVSAHYTLGTNWRSSADMVQAVNQVFALPDSPFIYDSDipFLPVKYSP 496
Cdd:TIGR00609 323 QKETSLFLIGDPKQAIYSFRGADIFTYLQAKSKADARYTLGTNWRSTPALVGSLNKLFSLISNPFLEKPI--FIPVLAHQ 400
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 497 NAEKRIWTMGGQKQPALTYWLQEAddKPLPKGEYLTRMAEATASQIQTILTQAQQGQACLVNGEKQKAVQAGDIAVLVRT 576
Cdd:TIGR00609 401 KNSKGSFVINGQEQPPIHFFTTEV--ESEGVDDYRQTIAQKCAREIALWLASAALGLANFIATFGGRPLRAGDIAVLVRG 478
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 577 GSEGRMVKQALADQGIASVYLSNRDSVFTSSVAQDLQRLLQAVLTPENDRALRASLASELFALDAASLDALNNDEVVWEN 656
Cdd:TIGR00609 479 RKEANQIRKALKKAQIPSVYLSDKSSVFATEEAQELLALLEALLEPENEGTLRAALASSIFGLSALELETLNQDEITWER 558
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 657 AVNEFKEYRKLWVQRGVLPMLRAVISKRHIAERLLEEgassqgENGERVLTDLMHIGELLQQASNELDSDHGLLRWLAQS 736
Cdd:TIGR00609 559 VVEKFREYHDIWRKIGVLAMFQRLMLEKGIGERLLSQ------PGGERILTNLLHLAELLQEAAHQERNKLSLLRWLEDQ 632
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 737 ISDAENGlggsDDQIQRLESERNLVQIVTIHKSKGLEYDLVFLPFVFSYREASEAKYYDAANDRTVL-DITGNDASMKQA 815
Cdd:TIGR00609 633 ISNEEEE----EEEIIRLESDAELVKIVTIHKSKGLEYPIVFLPFITDAKKSNFASLHDQHSHEYQLyDFNQSEENQKLA 708
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 816 DKERLAEDLRLIYVALTRAVYACFIGASPLRNGR-STKEPTGVHRSAIGYLIQNGQEGGINDLHQGLTKQQDELDCVVVA 894
Cdd:TIGR00609 709 RVERLAEDLRLLYVALTRAKKQLFIGIAPLITSKlSNLAYSALHNSALGYQKQDGETDNITGLKQCLAALADPAGISSIP 788
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 895 DPPQQLEDKYVAPQEEIhDLSAKELQNPIDRNWRITSYSGLVKQGSHHAEHDAtieiTGFDIDSSEEqdeadlvepERSI 974
Cdd:TIGR00609 789 AKPIGANSSKKEPASTA-LLEARTFHRRIRENWRITSFSSLKELEEAVTEEPA----PGLDYEVSSL---------EISA 854
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 975 FTFPRGARPGTFLHSLFEEIEFTQPATTEENTQIILGLMESEQLDEEWLPILQQLIDTVLVTPLDG-KSLLLNQKAPSQR 1053
Cdd:TIGR00609 855 QDFPKGKKTGTLLHAILESLIFSQAADLEKQNNLIAEKLKKTGLEGLWEPELQEWLEKMLNTPLTFsRAITLSQIDPEDR 934
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 1054 LVEMEFLLPIEVLSAPALNRVIQRHDPLSAKAGDLGFQTVQGMLKGFIDLVFEHQGKYYVLDWKSNHLGDDVTHYHGEAL 1133
Cdd:TIGR00609 935 QREMEFLLPINPEFQKQKLNFVIRAYPDRAGSPDLHFQLLRGLLKGFIDLVFEHNGRYYILDYKSNWLGKDASDYSPEAL 1014
|
1130 1140 1150 1160 1170 1180 1190
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 758852163 1134 KSAMADHRYDLQYQIYALALHRFLRSRLANYQYEQHFGGVYYLFLRGMDGQSDHGIFAAKPTLDFLREMDRLI 1206
Cdd:TIGR00609 1015 TEAILKERYDLQYLIYTLALHRYLRKRLKDYDYERHFGGVIYLFLRGIDGNKGNGIFFWNPPANLIDLLKELF 1087
|
|
| RecB |
COG1074 |
3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, ... |
27-1160 |
0e+00 |
|
3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];
Pssm-ID: 440692 [Multi-domain] Cd Length: 866 Bit Score: 693.63 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 27 FPLHGARLIEASAGTGKTFTIAGLYLRLLLGHgsaetrhrvPLTVDQILVVTFTEAATAELRDRIRARIHDARiafargQ 106
Cdd:COG1074 15 DPLGGSVLVEASAGSGKTYTLVARYLRLLLER---------GLDPEEILVVTFTRAAAAEMRERIRERLAEAA------D 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 107 SSDPVIQPLlnefddhKQAAEILLQAERQMDEAAVYTIHGFCQRMLTQNAFESGSRFNNEFVTD-ESHLKAQVVADYWRR 185
Cdd:COG1074 80 LEDPDLEEL-------ARARRRLARALENLDRAAISTIHSFCQRLLREFAFEAGLDPNFELLDDaEALLLEEAVDDLLRE 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 186 NFYPLPFTLAGEIRQLWS-SPSALLSDISnyltgaplslsvpamkgSLADLHTEnlkkidelkaqwresqddfftlisds 264
Cdd:COG1074 153 AYAPLDALALARLLDAFGrDDDSLEELLL-----------------ALYKLRSR-------------------------- 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 265 dinkrsytkkslPTWLEAVNAWAATettgydypdkLEKFAQNVLLEKtpkgsapqhAVFEAIETFLANPISLKAPLLAHA 344
Cdd:COG1074 190 ------------PDWLEELAELDEA----------LEALREALLKAK---------EALAALREALAAAAAPLLAALLRL 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 345 IEHCRVMLANAKNQKQWLSFDDLLTQLSASIDTDESELLAARIRTLYPVAMIDEFQDTDPLQYSIFSRIYLNDP--ECGL 422
Cdd:COG1074 239 LAAVLARYERRKRERGLLDFDDLLHRALRLLRDEDAPWVAERLRERYRHILVDEFQDTSPLQWEILRRLAGEALadGRTL 318
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 423 FMIGDPKQAIYGFRGADIFTYIKARNQVSAH-----YTLGTNWRSSADMVQAVNQVFALPDSPfiydsdiPFLPVKYSPN 497
Cdd:COG1074 319 FLVGDPKQSIYRFRGADPELFLEARRALEGRvdgerLTLTTNFRSTPEVVDAVNALFAQLMGA-------GFGEIPYEPV 391
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 498 AEKRiwtmgGQKQPALTYWLQEADDkpLPKGEYLTRMAEATASQIQTILTQAQQGqaclvnGEKQKAVQAGDIAVLVRTG 577
Cdd:COG1074 392 EALR-----PGAYPAVELWPLEPDD--VSEEDAREREARAVAARIRRLLAEGTTV------EGGGRPVRPGDIAVLVRTR 458
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 578 SEGRMVKQALADQGIAsVYLSNRDSVFTSSVAQDLQRLLQAVLTPENDRALRASLASELFALDAASLDALNND---EVVW 654
Cdd:COG1074 459 SEAAAIARALKAAGIP-VAASDRLSLFESPEVRDLLALLRALLNPEDDLALAAVLRSPLFGLSDEDLAALAADrkgESLW 537
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 655 E---------NAVNEFKEYRKLWVQRGVLPMLRAVISKRHIAERLLeegassQGENGERVLTDLMHIGELLQQAS----N 721
Cdd:COG1074 538 EalrayerlaRALERLRALRELARRLGLAELLERLLEETGLLERLL------ALPGGERRLANLLHLDELLQLALeyeqT 611
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 722 ELDSDHGLLRWLAQSISDaenglgGSDDQIQRLESERNLVQIVTIHKSKGLEYDLVFLPFVFsyreaseakyydaandrt 801
Cdd:COG1074 612 GGPGLAGFLRWLERLIED------GGDEEKRRLESDADAVRIMTIHKSKGLEFPVVFLPALR------------------ 667
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 802 vlditgndasmKQADKERLAEDLRLIYVALTRAVYACFIGAsplrngrstkeptgvhrsaigyliqngqeggindlhqgl 881
Cdd:COG1074 668 -----------ERARAEELAEELRLLYVALTRARDRLVLSG--------------------------------------- 697
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 882 tkqqdeldcvvvadppqqledkyvapqeeihdlSAKELQNPIDRNWritsysglvkqgshhaehdatieitgfdidssee 961
Cdd:COG1074 698 ---------------------------------AVKKKDAEKESSW---------------------------------- 710
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 962 qdeadlvepersiftfprGARPGTFLHSLFEEIEFTQPATTEEntqIILGLMESEQLDEEWLPILQQLIDTVLVTPLDGK 1041
Cdd:COG1074 711 ------------------LARRGTLVHRLLEHLDFSAPAELRA---ALARLLARGGLDEEEAEALAEALLAFLATPLLAE 769
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 1042 SLllnqkAPSQRLVEMEFLLPIEvlsapalnrviqrhdplsakagdlgFQTVQGMLKGFIDLVFEHQGKYYVLDWKSNHL 1121
Cdd:COG1074 770 LF-----AAAEVLREVPFLLPDL-------------------------YRGLGGLLKGRIDLVFEDDGRVYIVDYKTNRL 819
|
1130 1140 1150
....*....|....*....|....*....|....*....
gi 758852163 1122 GDDVTHYHGEalksamadhRYDLQYQIYALALHRFLRSR 1160
Cdd:COG1074 820 GPDDEEYLPE---------RYRLQLALYALALERLLPGR 849
|
|
| RecB_C-like |
cd22352 |
C-terminal nuclease domain of exodeoxyribonuclease V subunit RecB and similar proteins; ... |
927-1203 |
2.56e-87 |
|
C-terminal nuclease domain of exodeoxyribonuclease V subunit RecB and similar proteins; Exodeoxyribonuclease V subunit beta (RecB) is a helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair; it binds to DSBs and unwinds DNA via a rapid and highly processive ATP-dependent bidirectional helicase. The C-terminal PDDEXK nuclease domain belongs to a superfamily of nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.
Pssm-ID: 411756 [Multi-domain] Cd Length: 215 Bit Score: 281.86 E-value: 2.56e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 927 WRITSYSGLVKQGSHHAEHDatieitGFDIDSSEEQDEADLVEPERSIFTFPRGARPGTFLHSLFEEIeftqpatteent 1006
Cdd:cd22352 1 WRITSFSSLTRGLGGKAAEA------SHDEEPDEDEEAAPEEADEEGIDALPRGAKTGTFLHEILENI------------ 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 1007 qiilglmeseqldeewlpilqqlidtvlvtpldgkslllnqkapsQRLVEMEFLLPIE-VLSAPALNRVIQRHDPLSAkA 1085
Cdd:cd22352 63 ---------------------------------------------DRLSEMEFYLPLSdKLDAEALNELLRQHGPPGA-L 96
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 1086 GDLGFQTVQGMLKGFIDLVFEHQGKYYVLDWKSNHLGDDVTHYHGEALKSAMADHRYDLQYQIYALALHRFLRSRLANYQ 1165
Cdd:cd22352 97 PPLSFETLRGFLKGFIDLVFEHEGRYYILDYKSNYLGDYLEDYSPEALEAAMLEHHYDLQYLLYTLALHRYLKQRLPDYD 176
|
250 260 270
....*....|....*....|....*....|....*....
gi 758852163 1166 YEQHFGGVYYLFLRGMDG-QSDHGIFAAKPTLDFLREMD 1203
Cdd:cd22352 177 YERHFGGVYYLFLRGMDPeGPGNGVFFDRPSAELIEALD 215
|
|
| UvrD-helicase |
pfam00580 |
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural ... |
28-448 |
1.88e-38 |
|
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural domains. The Rep family function as dimers. REP helicases catalyze ATP dependent unwinding of double stranded DNA to single stranded DNA. Swiss:P23478, Swiss:P08394 have large insertions near to the carboxy-terminus relative to other members of the family.
Pssm-ID: 395462 [Multi-domain] Cd Length: 267 Bit Score: 145.08 E-value: 1.88e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 28 PLHGARLIEASAGTGKTFTIAGLYLRLLLGHGsaetrhrvpLTVDQILVVTFTEAATAELRDRIRARIhdariafargqs 107
Cdd:pfam00580 11 HLGGPLLVLAGAGSGKTRVLTERIAYLILEGG---------IDPEEILAVTFTNKAAREMKERILKLL------------ 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 108 sdpviqpllnefddhkqaaeillqAERQMDEAAVYTIHGFCQRMLTQNAFESGsrFNNEFVTDESHLKAQVVADywrrnf 187
Cdd:pfam00580 70 ------------------------GKAELSELNISTFHSFCLRILRKYANRIG--LLPNFSILDELDQLALLKE------ 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 188 yplpftlageirqlwsspsALLSDISNYltgaplslsvpamkgslaDLHTENLKKIDELKAQWRESQDDfftlisdsdin 267
Cdd:pfam00580 118 -------------------LLEKDRLNL------------------DPKLLRKLELKELISKAKNRLLS----------- 149
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 268 krsytkkslptwLEAVNAWAATettgyDYPDKLEKFAQnvllektpkgsapqhavfeaietflanpislkapllahaiEH 347
Cdd:pfam00580 150 ------------PEELQQGAAD-----PRDKLAAEFYQ----------------------------------------EY 172
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 348 CRVMLANAKnqkqwLSFDDLL---TQLSasidtDESELLAARIRTLYPVAMIDEFQDTDPLQYSIFSRIYLNDPEcgLFM 424
Cdd:pfam00580 173 QERLKENNA-----LDFDDLLlltLELL-----RSDPELLEAYRERFKYILVDEFQDTNPIQYRLLKLLAGGHEN--LFL 240
|
410 420
....*....|....*....|....
gi 758852163 425 IGDPKQAIYGFRGADIFTYIKARN 448
Cdd:pfam00580 241 VGDPDQSIYGFRGADIENILKFEK 264
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| recB |
PRK10876 |
exonuclease V subunit beta; Provisional |
18-1212 |
0e+00 |
|
exonuclease V subunit beta; Provisional
Pssm-ID: 236784 [Multi-domain] Cd Length: 1181 Bit Score: 1540.31 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 18 QPTPLEPMTFPLHGARLIEASAGTGKTFTIAGLYLRLLLGHGSAETRHRvPLTVDQILVVTFTEAATAELRDRIRARIHD 97
Cdd:PRK10876 5 VAETLDPLRLPLQGERLIEASAGTGKTFTIAALYLRLLLGLGGSAAFPR-PLTVEEILVVTFTEAATEELRGRIRSNIHE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 98 ARIAFARGQSSDPVIQPLLNEFDDHKQAAEILLQAERQMDEAAVYTIHGFCQRMLTQNAFESGSRFNNEFVTDESHLKAQ 177
Cdd:PRK10876 84 LRIACLREETDNPLYQRLLAEIDDKAQAAQWLLLAERQMDEAAIFTIHGFCQRMLNLNAFESGMLFEQQLIEDESLLRYQ 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 178 VVADYWRRNFYPLPFTLAGEIRQLWSSPSALLSDISNYLTG-APLSLSVPAMKGSLADLHTENLKKIDELKAQWRESQDD 256
Cdd:PRK10876 164 ACADFWRRHCYPLPREIARVVFQEWKGPEALLKDISRYLQGeAPVIKAPPPDDETLASRHEQIVARIDAVKQQWREAVGE 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 257 FFTLISDSDINKRSYTKKSLPTWLEAVNAWAATETTGYDYPDKLEKFAQNVLLEKTPKGSAPQHAVFEAIETFLANPISL 336
Cdd:PRK10876 244 LDALIESSGVDRRSYNSKNLPKWLEKISAWAEEETNSYQLPKELEKFSQRFLLEKTKKGETPQHPLFEAIDQLLAEPLSL 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 337 KAPLLAHAIEHCRVMLANAKNQKQWLSFDDLLTQLSASIDTDESELLAARIRTLYPVAMIDEFQDTDPLQYSIFSRIYLN 416
Cdd:PRK10876 324 RDLVITRALAEIRETVAQEKRRRGELGFDDLLSRLDSALQSEGGEALAAAIRTRYPVAMIDEFQDTDPQQYRIFRRIYRH 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 417 DPECGLFMIGDPKQAIYGFRGADIFTYIKARNQVSAHYTLGTNWRSSADMVQAVNQVFALPDSPFIYdSDIPFLPVKYSP 496
Cdd:PRK10876 404 QPETALLLIGDPKQAIYAFRGADIFTYMKARSEVSAHYTLDTNWRSAPGMVNSVNKLFSQTDDPFLF-REIPFIPVKAAG 482
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 497 NAEKRIWTMGGQKQPALTYWLQEADdkPLPKGEYLTRMAEATASQIQTILTQAQQGQACLVNGEKQKAVQAGDIAVLVRT 576
Cdd:PRK10876 483 KNQALRFVVKGETQPAMKFWLMEGE--GVGVGDYQQTMAQQCAAQIRDWLQAGQRGEALLMNGDDSRPVRASDITVLVRS 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 577 GSEGRMVKQALADQGIASVYLSNRDSVFTSSVAQDLQRLLQAVLTPENDRALRASLASELFALDAASLDALNNDEVVWEN 656
Cdd:PRK10876 561 RQEAALIRDALTLLAIPSVYLSNRDSVFETLEAQEMLWLLQAVLAPERERTLRSALATSMMGLDALDIDALNNDERAWDA 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 657 AVNEFKEYRKLWVQRGVLPMLRAVISKRHIAERLLeegASsqgENGERVLTDLMHIGELLQQASNELDSDHGLLRWLAQS 736
Cdd:PRK10876 641 LVEEFDGYRQIWRKRGVLPMLRALMSARNIAENLL---AT---AGGERRLTDILHIGELLQEASSQLDSEHALVRWLAQQ 714
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 737 ISDAEnglGGSDDQIQRLESERNLVQIVTIHKSKGLEYDLVFLPFVFSYREASEAKYYDAANDRTVLDITGNDASMKQAD 816
Cdd:PRK10876 715 ILEPD---SQASSQQLRLESDKHLVQIVTIHKSKGLEYPLVWLPFITNFRVQDQAFYHDRHSFEAVLDLNAAEESVALAE 791
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 817 KERLAEDLRLIYVALTRAVYACFIGASPLRNGRSTKE-PTGVHRSAIGYLIQNGQEGGINDLHQGLtkQQDELDCVVVAD 895
Cdd:PRK10876 792 EERLAEDLRLLYVALTRSVWHCSLGVAPLVRRRRKKKgETDLHQSALGYLLQKGEPGDAAGLRACL--EALCDDDIALQT 869
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 896 PPQQLEDKYVAPQEEIHDLSAKELQNPIDRNWRITSYSGLVKQGSHHAEhdatiEIT-GFDIDSSEEQDEADlvEPERSI 974
Cdd:PRK10876 870 AQETDNQPWQPQDASLAELSARTLQRLLQDNWRVTSYSGLQQHGHSIAQ-----DLLpRLDVDAAGEGSVVE--EPQLTP 942
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 975 FTFPRGARPGTFLHSLFEEIEFTQPATTEentqiilglMESEQL-----DEEWLPILQQLIDTVLVTPLDGKSLLLNQKA 1049
Cdd:PRK10876 943 HTFPRGASPGTFLHSLFEDLDFTQPVDPE---------WLQEQLelqgfEEQWEPVLTQWITAVLQTPLNETGVSLSQLS 1013
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 1050 PSQRLVEMEFLLPIE-VLSAPALNRVIQRHDPLSAKAGDLGFQTVQGMLKGFIDLVFEHQGKYYVLDWKSNHLGDDVTHY 1128
Cdd:PRK10876 1014 ARDKQVEMQFYLPIDqPLTASQLDALIRQYDPLSAGCPPLDFMQVRGMLKGFIDLVFRWQGRYYLLDYKSNWLGEDSSAY 1093
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 1129 HGEALKSAMADHRYDLQYQIYALALHRFLRSRLANYQYEQHFGGVYYLFLRGMDGQ-SDHGIFAAKPTLDFLREMDRLID 1207
Cdd:PRK10876 1094 TQEAMAQAMQAHRYDLQYQLYTLALHRYLRHRLADYDYQRHFGGVIYLFLRGVDKEhPGQGIFTTRPNAALIDGLDELFA 1173
|
....*
gi 758852163 1208 GQVLE 1212
Cdd:PRK10876 1174 GETLE 1178
|
|
| recB |
TIGR00609 |
exodeoxyribonuclease V, beta subunit; The RecBCD holoenzyme is a multifunctional nuclease with ... |
22-1206 |
0e+00 |
|
exodeoxyribonuclease V, beta subunit; The RecBCD holoenzyme is a multifunctional nuclease with potent ATP-dependent exodeoxyribonuclease activity. Ejection of RecD, as occurs at chi recombinational hotspots, cripples exonuclease activity in favor of recombinagenic helicase activity. All proteins in this family for which functions are known are DNA-DNA helicases that are used as part of an exonuclease-helicase complex (made up of RecBCD homologs) that function to generate substrates for the initiation of recombination and recombinational repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273172 [Multi-domain] Cd Length: 1087 Bit Score: 1013.12 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 22 LEPMTFPLHGARLIEASAGTGKTFTIAGLYLRLLLGHGsaetrhrvPLTVDQILVVTFTEAATAELRDRIRARIHDARIA 101
Cdd:TIGR00609 1 LDPLTIPLNGTFLIEASAGTGKTFTIAQLYLRLLLEGG--------PLTVEEILVVTFTNAATEELKTRIRGRIHQALRA 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 102 FARGQSSDPVIQPLLNEFDDHK--QAAEILLQAERQMDEAAVYTIHGFCQRMLTQNAFESGSRFNNEFVTDESHLKAQVV 179
Cdd:TIGR00609 73 LKAALTSQELPEPLKEAIQDEKvkQAITRLRNALATMDEAAIYTIHGFCQRMLEQHAFESDEIFDVELIEDESLLLAEIT 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 180 ADYWRRNFYPLPFTLAGEIRQLWSSPSALLSDISNYLTGaPLSLSVPAMkgsladlhTENLKKIDELKAQWRESQDDFft 259
Cdd:TIGR00609 153 KDFWRRNFYNLPFDIAQIVLKTKKSPQAVLTQILADLLL-QSYLAFPSP--------PLDLEQLIKWHEQIYKDLDKL-- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 260 lisdsdinkrsytkkslptwleavnawaatettgydypdklekfaqnvllektpkgsapQHAVFEAIET---FLANPISL 336
Cdd:TIGR00609 222 -----------------------------------------------------------DHAVFEEIDKlnaERNNLFCL 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 337 KAPLLAHAIEHCRVMLANAKNQKQWLSFDDLLTQLSASIDTDESELLAARIRTLYPVAMIDEFQDTDPLQYSIFSRIYLN 416
Cdd:TIGR00609 243 KDRVFLTLLKEVQEELKKEKKRRREIGFDDLLSRLETALKSAEGEKLAQAIREQYPIALIDEFQDTDPQQYRIFSKLFIA 322
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 417 DPECGLFMIGDPKQAIYGFRGADIFTYIKARNQVSAHYTLGTNWRSSADMVQAVNQVFALPDSPFIYDSDipFLPVKYSP 496
Cdd:TIGR00609 323 QKETSLFLIGDPKQAIYSFRGADIFTYLQAKSKADARYTLGTNWRSTPALVGSLNKLFSLISNPFLEKPI--FIPVLAHQ 400
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 497 NAEKRIWTMGGQKQPALTYWLQEAddKPLPKGEYLTRMAEATASQIQTILTQAQQGQACLVNGEKQKAVQAGDIAVLVRT 576
Cdd:TIGR00609 401 KNSKGSFVINGQEQPPIHFFTTEV--ESEGVDDYRQTIAQKCAREIALWLASAALGLANFIATFGGRPLRAGDIAVLVRG 478
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 577 GSEGRMVKQALADQGIASVYLSNRDSVFTSSVAQDLQRLLQAVLTPENDRALRASLASELFALDAASLDALNNDEVVWEN 656
Cdd:TIGR00609 479 RKEANQIRKALKKAQIPSVYLSDKSSVFATEEAQELLALLEALLEPENEGTLRAALASSIFGLSALELETLNQDEITWER 558
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 657 AVNEFKEYRKLWVQRGVLPMLRAVISKRHIAERLLEEgassqgENGERVLTDLMHIGELLQQASNELDSDHGLLRWLAQS 736
Cdd:TIGR00609 559 VVEKFREYHDIWRKIGVLAMFQRLMLEKGIGERLLSQ------PGGERILTNLLHLAELLQEAAHQERNKLSLLRWLEDQ 632
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 737 ISDAENGlggsDDQIQRLESERNLVQIVTIHKSKGLEYDLVFLPFVFSYREASEAKYYDAANDRTVL-DITGNDASMKQA 815
Cdd:TIGR00609 633 ISNEEEE----EEEIIRLESDAELVKIVTIHKSKGLEYPIVFLPFITDAKKSNFASLHDQHSHEYQLyDFNQSEENQKLA 708
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 816 DKERLAEDLRLIYVALTRAVYACFIGASPLRNGR-STKEPTGVHRSAIGYLIQNGQEGGINDLHQGLTKQQDELDCVVVA 894
Cdd:TIGR00609 709 RVERLAEDLRLLYVALTRAKKQLFIGIAPLITSKlSNLAYSALHNSALGYQKQDGETDNITGLKQCLAALADPAGISSIP 788
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 895 DPPQQLEDKYVAPQEEIhDLSAKELQNPIDRNWRITSYSGLVKQGSHHAEHDAtieiTGFDIDSSEEqdeadlvepERSI 974
Cdd:TIGR00609 789 AKPIGANSSKKEPASTA-LLEARTFHRRIRENWRITSFSSLKELEEAVTEEPA----PGLDYEVSSL---------EISA 854
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 975 FTFPRGARPGTFLHSLFEEIEFTQPATTEENTQIILGLMESEQLDEEWLPILQQLIDTVLVTPLDG-KSLLLNQKAPSQR 1053
Cdd:TIGR00609 855 QDFPKGKKTGTLLHAILESLIFSQAADLEKQNNLIAEKLKKTGLEGLWEPELQEWLEKMLNTPLTFsRAITLSQIDPEDR 934
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 1054 LVEMEFLLPIEVLSAPALNRVIQRHDPLSAKAGDLGFQTVQGMLKGFIDLVFEHQGKYYVLDWKSNHLGDDVTHYHGEAL 1133
Cdd:TIGR00609 935 QREMEFLLPINPEFQKQKLNFVIRAYPDRAGSPDLHFQLLRGLLKGFIDLVFEHNGRYYILDYKSNWLGKDASDYSPEAL 1014
|
1130 1140 1150 1160 1170 1180 1190
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 758852163 1134 KSAMADHRYDLQYQIYALALHRFLRSRLANYQYEQHFGGVYYLFLRGMDGQSDHGIFAAKPTLDFLREMDRLI 1206
Cdd:TIGR00609 1015 TEAILKERYDLQYLIYTLALHRYLRKRLKDYDYERHFGGVIYLFLRGIDGNKGNGIFFWNPPANLIDLLKELF 1087
|
|
| RecB |
COG1074 |
3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, ... |
27-1160 |
0e+00 |
|
3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];
Pssm-ID: 440692 [Multi-domain] Cd Length: 866 Bit Score: 693.63 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 27 FPLHGARLIEASAGTGKTFTIAGLYLRLLLGHgsaetrhrvPLTVDQILVVTFTEAATAELRDRIRARIHDARiafargQ 106
Cdd:COG1074 15 DPLGGSVLVEASAGSGKTYTLVARYLRLLLER---------GLDPEEILVVTFTRAAAAEMRERIRERLAEAA------D 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 107 SSDPVIQPLlnefddhKQAAEILLQAERQMDEAAVYTIHGFCQRMLTQNAFESGSRFNNEFVTD-ESHLKAQVVADYWRR 185
Cdd:COG1074 80 LEDPDLEEL-------ARARRRLARALENLDRAAISTIHSFCQRLLREFAFEAGLDPNFELLDDaEALLLEEAVDDLLRE 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 186 NFYPLPFTLAGEIRQLWS-SPSALLSDISnyltgaplslsvpamkgSLADLHTEnlkkidelkaqwresqddfftlisds 264
Cdd:COG1074 153 AYAPLDALALARLLDAFGrDDDSLEELLL-----------------ALYKLRSR-------------------------- 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 265 dinkrsytkkslPTWLEAVNAWAATettgydypdkLEKFAQNVLLEKtpkgsapqhAVFEAIETFLANPISLKAPLLAHA 344
Cdd:COG1074 190 ------------PDWLEELAELDEA----------LEALREALLKAK---------EALAALREALAAAAAPLLAALLRL 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 345 IEHCRVMLANAKNQKQWLSFDDLLTQLSASIDTDESELLAARIRTLYPVAMIDEFQDTDPLQYSIFSRIYLNDP--ECGL 422
Cdd:COG1074 239 LAAVLARYERRKRERGLLDFDDLLHRALRLLRDEDAPWVAERLRERYRHILVDEFQDTSPLQWEILRRLAGEALadGRTL 318
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 423 FMIGDPKQAIYGFRGADIFTYIKARNQVSAH-----YTLGTNWRSSADMVQAVNQVFALPDSPfiydsdiPFLPVKYSPN 497
Cdd:COG1074 319 FLVGDPKQSIYRFRGADPELFLEARRALEGRvdgerLTLTTNFRSTPEVVDAVNALFAQLMGA-------GFGEIPYEPV 391
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 498 AEKRiwtmgGQKQPALTYWLQEADDkpLPKGEYLTRMAEATASQIQTILTQAQQGqaclvnGEKQKAVQAGDIAVLVRTG 577
Cdd:COG1074 392 EALR-----PGAYPAVELWPLEPDD--VSEEDAREREARAVAARIRRLLAEGTTV------EGGGRPVRPGDIAVLVRTR 458
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 578 SEGRMVKQALADQGIAsVYLSNRDSVFTSSVAQDLQRLLQAVLTPENDRALRASLASELFALDAASLDALNND---EVVW 654
Cdd:COG1074 459 SEAAAIARALKAAGIP-VAASDRLSLFESPEVRDLLALLRALLNPEDDLALAAVLRSPLFGLSDEDLAALAADrkgESLW 537
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 655 E---------NAVNEFKEYRKLWVQRGVLPMLRAVISKRHIAERLLeegassQGENGERVLTDLMHIGELLQQAS----N 721
Cdd:COG1074 538 EalrayerlaRALERLRALRELARRLGLAELLERLLEETGLLERLL------ALPGGERRLANLLHLDELLQLALeyeqT 611
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 722 ELDSDHGLLRWLAQSISDaenglgGSDDQIQRLESERNLVQIVTIHKSKGLEYDLVFLPFVFsyreaseakyydaandrt 801
Cdd:COG1074 612 GGPGLAGFLRWLERLIED------GGDEEKRRLESDADAVRIMTIHKSKGLEFPVVFLPALR------------------ 667
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 802 vlditgndasmKQADKERLAEDLRLIYVALTRAVYACFIGAsplrngrstkeptgvhrsaigyliqngqeggindlhqgl 881
Cdd:COG1074 668 -----------ERARAEELAEELRLLYVALTRARDRLVLSG--------------------------------------- 697
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 882 tkqqdeldcvvvadppqqledkyvapqeeihdlSAKELQNPIDRNWritsysglvkqgshhaehdatieitgfdidssee 961
Cdd:COG1074 698 ---------------------------------AVKKKDAEKESSW---------------------------------- 710
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 962 qdeadlvepersiftfprGARPGTFLHSLFEEIEFTQPATTEEntqIILGLMESEQLDEEWLPILQQLIDTVLVTPLDGK 1041
Cdd:COG1074 711 ------------------LARRGTLVHRLLEHLDFSAPAELRA---ALARLLARGGLDEEEAEALAEALLAFLATPLLAE 769
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 1042 SLllnqkAPSQRLVEMEFLLPIEvlsapalnrviqrhdplsakagdlgFQTVQGMLKGFIDLVFEHQGKYYVLDWKSNHL 1121
Cdd:COG1074 770 LF-----AAAEVLREVPFLLPDL-------------------------YRGLGGLLKGRIDLVFEDDGRVYIVDYKTNRL 819
|
1130 1140 1150
....*....|....*....|....*....|....*....
gi 758852163 1122 GDDVTHYHGEalksamadhRYDLQYQIYALALHRFLRSR 1160
Cdd:COG1074 820 GPDDEEYLPE---------RYRLQLALYALALERLLPGR 849
|
|
| RecB_C-like |
cd22352 |
C-terminal nuclease domain of exodeoxyribonuclease V subunit RecB and similar proteins; ... |
927-1203 |
2.56e-87 |
|
C-terminal nuclease domain of exodeoxyribonuclease V subunit RecB and similar proteins; Exodeoxyribonuclease V subunit beta (RecB) is a helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair; it binds to DSBs and unwinds DNA via a rapid and highly processive ATP-dependent bidirectional helicase. The C-terminal PDDEXK nuclease domain belongs to a superfamily of nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.
Pssm-ID: 411756 [Multi-domain] Cd Length: 215 Bit Score: 281.86 E-value: 2.56e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 927 WRITSYSGLVKQGSHHAEHDatieitGFDIDSSEEQDEADLVEPERSIFTFPRGARPGTFLHSLFEEIeftqpatteent 1006
Cdd:cd22352 1 WRITSFSSLTRGLGGKAAEA------SHDEEPDEDEEAAPEEADEEGIDALPRGAKTGTFLHEILENI------------ 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 1007 qiilglmeseqldeewlpilqqlidtvlvtpldgkslllnqkapsQRLVEMEFLLPIE-VLSAPALNRVIQRHDPLSAkA 1085
Cdd:cd22352 63 ---------------------------------------------DRLSEMEFYLPLSdKLDAEALNELLRQHGPPGA-L 96
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 1086 GDLGFQTVQGMLKGFIDLVFEHQGKYYVLDWKSNHLGDDVTHYHGEALKSAMADHRYDLQYQIYALALHRFLRSRLANYQ 1165
Cdd:cd22352 97 PPLSFETLRGFLKGFIDLVFEHEGRYYILDYKSNYLGDYLEDYSPEALEAAMLEHHYDLQYLLYTLALHRYLKQRLPDYD 176
|
250 260 270
....*....|....*....|....*....|....*....
gi 758852163 1166 YEQHFGGVYYLFLRGMDG-QSDHGIFAAKPTLDFLREMD 1203
Cdd:cd22352 177 YERHFGGVYYLFLRGMDPeGPGNGVFFDRPSAELIEALD 215
|
|
| UvrD |
COG0210 |
Superfamily I DNA or RNA helicase [Replication, recombination and repair]; |
31-834 |
1.08e-40 |
|
Superfamily I DNA or RNA helicase [Replication, recombination and repair];
Pssm-ID: 439980 [Multi-domain] Cd Length: 721 Bit Score: 161.64 E-value: 1.08e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 31 GARLIEASAGTGKTFTIAGLYLRLLLGHGSAetrhrvPltvDQILVVTFTEAATAELRDRIRARIhdariafargqssdp 110
Cdd:COG0210 20 GPLLVLAGAGSGKTRVLTHRIAYLIAEGGVD------P---EQILAVTFTNKAAREMRERIEALL--------------- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 111 viqpllnefddhkqaaeillqaERQMDEAAVYTIHGFCQRMLTQNAFESGsrfnnefvtdeshlkaqvvadywrrnfYPL 190
Cdd:COG0210 76 ----------------------GRLARGLWVGTFHSLALRILRRHAELLG---------------------------LPP 106
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 191 PFTLAGEIRQLwsspsALLSDIsnyltgaplslsvpamkgsladlhtenlkkidelkaqwresqddfftlISDSDINKRS 270
Cdd:COG0210 107 NFTILDGDDQL-----RLIKEL------------------------------------------------LKELGLDEKR 133
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 271 YTKKSLptwLEAVNAWAATETTGYDYPDKLEKFAQNVLLEKtpkgsapqhaVFEAIEtflanpislkapllahaiEHCRv 350
Cdd:COG0210 134 FPPREL---LSLISRAKNEGLTPEELAELLAADPEWRAAAE----------LYEAYQ------------------ERLR- 181
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 351 mlanaknQKQWLSFDDLLTqLSASIdTDESELLAARIRTLYPVAMIDEFQDTDPLQYSIFSRiyLNDPECGLFMIGDPKQ 430
Cdd:COG0210 182 -------ANNALDFDDLLL-LAVRL-LEENPEVLEKYQNRFRYILVDEYQDTNPAQYELLRL--LAGDGRNLCVVGDDDQ 250
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 431 AIYGFRGADIfTYIKarnQVSAHY------TLGTNWRSSADMVQAVNQVfalpdspfiydsdIPFLPVKYspnaEKRIWT 504
Cdd:COG0210 251 SIYGFRGADP-ENIL---RFEKDFpdakviKLEQNYRSTQNILDAANAV-------------IANNPGRL----GKNLWT 309
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 505 MGGQKQPALTYwlqEADDkplpkgeyltrmAEATASQI-QTILTQAQQGqaclvngekqkaVQAGDIAVLVRTGSEGRMV 583
Cdd:COG0210 310 DNGEGEKVRLY---VAPD------------EEEEARFVaDEIRELHEEG------------VPLSDIAVLYRTNAQSRAL 362
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 584 KQALADQGIAsVYLSNRDSVFTSSVAQDLQRLLQAVLTPENDRALRASLASELFALDAASLDAL-----NNDEVVWE--- 655
Cdd:COG0210 363 EEALRRAGIP-YRVVGGLRFYERAEIKDLLAYLRLLANPDDDVALLRILNVPRRGIGAATLERLreaarEEGISLLEalr 441
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 656 -------------NAVNEFKEY-RKLWVQRGVLP---MLRAVISKRHIAERLLEEgassqgeNGERVLTDLMHIGELLQQ 718
Cdd:COG0210 442 dlgelaglsgraaKALRRFAELlEALRAAAERLPleeLLEALLDESGYEEELREE-------AGEEAERRLENLEELVDA 514
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 719 ASN--ELDSDHGLLRWLAQ-SISDAENGLGGSDDQiqrlesernlVQIVTIHKSKGLEYDLVFLPF----VFSYREASEa 791
Cdd:COG0210 515 AARfeERNPGASLEAFLEElALLSDLDAADEDEDA----------VTLMTLHAAKGLEFPVVFLVGleegLFPHQRSLD- 583
|
810 820 830 840
....*....|....*....|....*....|....*....|...
gi 758852163 792 kyydaandrtvlditgndasmkqaDKERLAEDLRLIYVALTRA 834
Cdd:COG0210 584 ------------------------DEEELEEERRLFYVAITRA 602
|
|
| UvrD-helicase |
pfam00580 |
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural ... |
28-448 |
1.88e-38 |
|
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural domains. The Rep family function as dimers. REP helicases catalyze ATP dependent unwinding of double stranded DNA to single stranded DNA. Swiss:P23478, Swiss:P08394 have large insertions near to the carboxy-terminus relative to other members of the family.
Pssm-ID: 395462 [Multi-domain] Cd Length: 267 Bit Score: 145.08 E-value: 1.88e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 28 PLHGARLIEASAGTGKTFTIAGLYLRLLLGHGsaetrhrvpLTVDQILVVTFTEAATAELRDRIRARIhdariafargqs 107
Cdd:pfam00580 11 HLGGPLLVLAGAGSGKTRVLTERIAYLILEGG---------IDPEEILAVTFTNKAAREMKERILKLL------------ 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 108 sdpviqpllnefddhkqaaeillqAERQMDEAAVYTIHGFCQRMLTQNAFESGsrFNNEFVTDESHLKAQVVADywrrnf 187
Cdd:pfam00580 70 ------------------------GKAELSELNISTFHSFCLRILRKYANRIG--LLPNFSILDELDQLALLKE------ 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 188 yplpftlageirqlwsspsALLSDISNYltgaplslsvpamkgslaDLHTENLKKIDELKAQWRESQDDfftlisdsdin 267
Cdd:pfam00580 118 -------------------LLEKDRLNL------------------DPKLLRKLELKELISKAKNRLLS----------- 149
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 268 krsytkkslptwLEAVNAWAATettgyDYPDKLEKFAQnvllektpkgsapqhavfeaietflanpislkapllahaiEH 347
Cdd:pfam00580 150 ------------PEELQQGAAD-----PRDKLAAEFYQ----------------------------------------EY 172
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 348 CRVMLANAKnqkqwLSFDDLL---TQLSasidtDESELLAARIRTLYPVAMIDEFQDTDPLQYSIFSRIYLNDPEcgLFM 424
Cdd:pfam00580 173 QERLKENNA-----LDFDDLLlltLELL-----RSDPELLEAYRERFKYILVDEFQDTNPIQYRLLKLLAGGHEN--LFL 240
|
410 420
....*....|....*....|....
gi 758852163 425 IGDPKQAIYGFRGADIFTYIKARN 448
Cdd:pfam00580 241 VGDPDQSIYGFRGADIENILKFEK 264
|
|
| PRK13909 |
PRK13909 |
RecB-like helicase; |
36-840 |
5.50e-24 |
|
RecB-like helicase;
Pssm-ID: 237554 [Multi-domain] Cd Length: 910 Bit Score: 109.29 E-value: 5.50e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 36 EASAGTGKTFTIAGLYLRLLLGHGSAetrhrvpltvDQILVVTFTEAATAELRDRIrariHDARIAFARGQSSdPVIQPL 115
Cdd:PRK13909 4 KASAGSGKTFALSVRFLALLFKGANP----------SEILALTFTKKAANEMKERI----IDTLLNLEKEKEE-SELNEL 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 116 LNEFddHKQAAEILLQAERQMD-----EAAVYTIHGFCQRMLTQNAFESGsrFNNEFVTDEShLKAQVVADywrrnfypl 190
Cdd:PRK13909 69 EEKL--GLSKEELLNKRDKVYQeflnsELKISTIDAFFQKILRKFCLNLG--LSPDFSIKED-TKEELNEK--------- 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 191 pFTLAGEIRQLWSSpSALLSDISNYLTGAPLSLsvpamkgsLADLHTEN--LKKIDelKAQWRESQDDFFTLISDSDINK 268
Cdd:PRK13909 135 -FLSALSKEELLEL-LAFIKQCESKKNNSFFEL--------LEKLYEKNneLKLFE--KAKNPIEFDEEKFLEELRSLKQ 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 269 RSYTKKSLPTwleavNAWAATETtgydypDKLEKFAQNVLLEKTPKGSapqHAVFE--AIETFLANPISLKAPLLAHAIE 346
Cdd:PRK13909 203 QIQSIETASK-----NAKKAFKK------EDFEELLNSSKTWLEKESE---YRYFKklYNEELDAEFEELKNALKRYYDA 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 347 HCRVMLA----------NAKNQ----KQWLSFDD-------LLTQlsasiDTDESELLAARIRTLYPVAMIDEFQDTDPL 405
Cdd:PRK13909 269 KENYKLSklfkllqlykEAKNElnkkKNALDFDDiskkvyeLLGE-----EEIDKDFLYFRLDSKISHILIDEFQDTSVL 343
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 406 QYSIF--------SRIYLNDpECGLFMIGDPKQAIYGFRG--ADIFTYIKARNQVsAHYTLGTNWRSSADMVQAVNQVFA 475
Cdd:PRK13909 344 QYKILlplideikSGEGQKK-FRSFFYVGDVKQSIYRFRGgkKELFDKVSKDFKQ-KVDNLDTNYRSAPLIVDFVNEVFK 421
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 476 LpdspfiydsDIPFLPVKYSPNAEKriwtmGGqkqpaltYW--LQEADDKPLpkgeyltrMAEATASQIQTILtqaqqgq 553
Cdd:PRK13909 422 K---------KYKNYKTQYAEQHKS-----GG-------YVevVEVADESEE--------LLEQLLQEIQFLL------- 465
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 554 aclvngekQKAVQAGDIAVLVRTGSEGRMVKQALADQ-GIasvylsnrdSVFTSSVAQDLQRllqavltpENDRALRASL 632
Cdd:PRK13909 466 --------EKGIDPDDIAILCWTNDDALEIKEFLQEQfGI---------KAVTESSAKLINQ--------PEVKALIEAL 520
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 633 aseLFALDAASLDALNNDEVVWENAVnefKEYRKLWVQRGVLPMLRAVISKRHIAE----RLLEEgaSSQGENgervltd 708
Cdd:PRK13909 521 ---KYCLFGEEIYKHNVLKLLGKEPD---KIPSFLPKEESVAEFVKKLIEELKLYDenllKFLEL--ASGYED------- 585
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 709 lmhIGELLqqasNELDSdhgllrwLAQSISDAENglggsddqiqrleserNLVQIVTIHKSKGLEYDLVFL--------- 779
Cdd:PRK13909 586 ---IEEFL----FKLEP-------CDKEIASEES----------------KGVQIMTVHKSKGLEFEHVIVcdrlgkpns 635
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 758852163 780 ---PFVFSYrEASEAK--YYDAANdRTVLDitGNDASMKQADKERLAEDLR-LIYVALTRAVYACFI 840
Cdd:PRK13909 636 dssNLLFEY-DGIELWqiYYRIKG-RENFD--KDYARALEKEKALKYEEEInVLYVAFTRAKNSLIV 698
|
|
| DEXQc_UvrD |
cd17932 |
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch ... |
359-460 |
9.21e-21 |
|
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. UvrD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350690 [Multi-domain] Cd Length: 189 Bit Score: 91.42 E-value: 9.21e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 359 KQWLSFDDLLTQLSASIDTDESelLAARIRTLYPVAMIDEFQDTDPLQYSIFSRiyLNDPECGLFMIGDPKQAIYGFRGA 438
Cdd:cd17932 90 RRYGDFDDLLLYALELLEENPD--VREKLQSRFRYILVDEYQDTNPLQYELLKL--LAGDGKNLFVVGDDDQSIYGFRGA 165
|
90 100
....*....|....*....|....
gi 758852163 439 DIFTYIKARNQ--VSAHYTLGTNW 460
Cdd:cd17932 166 DPENILDFEKDfpDAKVIKLEENY 189
|
|
| SF1_C_UvrD |
cd18807 |
C-terminal helicase domain of UvrD family helicases; UvrD is a highly conserved helicase ... |
750-841 |
2.82e-18 |
|
C-terminal helicase domain of UvrD family helicases; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. This family also includes ATP-dependent helicase/nuclease AddA and helicase/nuclease RecBCD subunit RecB, among others. UvrD family helicases are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350194 [Multi-domain] Cd Length: 150 Bit Score: 83.05 E-value: 2.82e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 750 QIQRLESERnLVQIVTIHKSKGLEYDLVFLPFVFSYREASEAKYydaandrtvlditgndaSMKQADKERLAEDLRLIYV 829
Cdd:cd18807 76 QARVIEEAL-RVTLMTIHASKGLEFPVVFIVGLGEGFIPSDASY-----------------HAAKEDEERLEEERRLLYV 137
|
90
....*....|..
gi 758852163 830 ALTRAVYACFIG 841
Cdd:cd18807 138 ALTRAKKELYLV 149
|
|
| DEXQc_UvrD |
cd17932 |
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch ... |
31-156 |
4.83e-16 |
|
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. UvrD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350690 [Multi-domain] Cd Length: 189 Bit Score: 77.56 E-value: 4.83e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 31 GARLIEASAGTGKTFTIAGLYLRLLLghgsaetRHRVPltVDQILVVTFTEAATAELRDRIRARIHDARiafargqssdp 110
Cdd:cd17932 13 GPLLVLAGAGSGKTRVLTHRIAYLIL-------EGGVP--PERILAVTFTNKAAKEMRERLRKLLGEQL----------- 72
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 758852163 111 viqpllnefddhkqaaeillqaerqMDEAAVYTIHGFCQRMLTQNA 156
Cdd:cd17932 73 -------------------------ASGVWIGTFHSFALRILRRYG 93
|
|
| UvrD_C |
pfam13361 |
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety ... |
682-840 |
1.03e-09 |
|
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety of helicase enzymes. This domain has a AAA-like structural fold.
Pssm-ID: 433145 [Multi-domain] Cd Length: 377 Bit Score: 62.04 E-value: 1.03e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 682 SKRHIAERLLEEGAS-----SQGENGERVLTDLMH----IGELLQQASNELDSDHGLLRWLAQSISDAENGLGGSDDqiq 752
Cdd:pfam13361 229 LKKPVGDSLQVHGFSdeflqENGETPAEALRDFLEklenLRELYSILREYDDIEETPEPEDALRNFLEIATLSNSEL--- 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 753 RLESERNLVQIVTIHKSKGLEYDLVFLpfvfsyreaseakyYDAANDRTvlditgnDASMKQADKERLAEDLRLIYVALT 832
Cdd:pfam13361 306 EGSDIKERIPIMTIHQAKGLEFDTVFL--------------AGLEEGIF-------PSYRSIKDEGNLEEERRLFYVAIT 364
|
....*...
gi 758852163 833 RAVYACFI 840
Cdd:pfam13361 365 RAKKRLYI 372
|
|
| SF1_C |
cd18786 |
C-terminal helicase domain of superfamily 1 DEAD/H-box helicases; Superfamily (SF)1 family ... |
753-842 |
3.31e-09 |
|
C-terminal helicase domain of superfamily 1 DEAD/H-box helicases; Superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Similar to SF2 helicases, they do not form toroidal, predominantly hexameric structures like SF3-6. SF1 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350173 [Multi-domain] Cd Length: 89 Bit Score: 55.14 E-value: 3.31e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 753 RLESERNLVQIVTIHKSKGLEYDLVFLPFVfsyreaseakyydaandrtvlditgndasmkqadkERLAEDLRLIYVALT 832
Cdd:cd18786 35 LDEFDLQLVGAITIDSSQGLTFDVVTLYLP-----------------------------------TANSLTPRRLYVALT 79
|
90
....*....|
gi 758852163 833 RAVYACFIGA 842
Cdd:cd18786 80 RARKRLVIYD 89
|
|
| uvrD |
PRK11773 |
DNA-dependent helicase II; Provisional |
395-475 |
1.28e-06 |
|
DNA-dependent helicase II; Provisional
Pssm-ID: 236976 [Multi-domain] Cd Length: 721 Bit Score: 52.95 E-value: 1.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 395 MIDEFQDTDPLQYSiFSRIyLNDPECGLFMIGDPKQAIYGFRGADIFTYIKARNQVSAHYT--LGTNWRSSADMVQAVNQ 472
Cdd:PRK11773 218 LVDEFQDTNAIQYA-WIRL-LAGDTGKVMIVGDDDQSIYGWRGAQVENIQRFLNDFPGAETirLEQNYRSTANILKAANA 295
|
...
gi 758852163 473 VFA 475
Cdd:PRK11773 296 LIA 298
|
|
| PRK10919 |
PRK10919 |
ATP-dependent DNA helicase Rep; Provisional |
362-834 |
1.11e-05 |
|
ATP-dependent DNA helicase Rep; Provisional
Pssm-ID: 182838 [Multi-domain] Cd Length: 672 Bit Score: 49.84 E-value: 1.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 362 LSFDDLLTQLSASIDTDES--ELLAARIRTLypvaMIDEFQDTDPLQYSIFSriYLNDPECGLFMIGDPKQAIYGFRGAD 439
Cdd:PRK10919 181 LDFDDLILLPTLLLQRNEEvrERWQNKIRYL----LVDEYQDTNTSQYELVK--LLVGSRARFTVVGDDDQSIYSWRGAR 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 440 IFTYIKARNQVSAHYT--LGTNWRSSADMVQAVNQVFAlpDSPFIYdsdipflpvkyspnaEKRIWTmggqkqpALTYwl 517
Cdd:PRK10919 255 PQNLVLLSQDFPALQVikLEQNYRSSGRILKAANILIA--NNPHVF---------------EKRLFS-------ELGY-- 308
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 518 qeaddkplpkgeyltrmaeatASQIQTILTQAQQGQACLVNGEK-----QKAVQAGDIAVLVRTGSEGRMVKQALADQGI 592
Cdd:PRK10919 309 ---------------------GDELKVLSANNEEHEAERVTGELiahhfVNKTQYKDYAILYRGNHQSRVFEKFLMQNRI 367
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 593 aSVYLSNRDSVFTSSVAQDLQRLLQAVLTPENDRALRASLASELFALDAASLDALNNdevvWENAVNEfkeyrklwvqrg 672
Cdd:PRK10919 368 -PYKISGGTSFFSRPEIKDLLAYLRVLTNPDDDSAFLRIVNTPKREIGPATLQKLGE----WAMTRNK------------ 430
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 673 vlPMLRAVIS---KRHIAERLLEEgassqgengervLTDLMH-IGELLQQASNE-----LDSDHGL--LRWLAQSISDAE 741
Cdd:PRK10919 431 --SLFTASFDmglSQTLSGRGYES------------LTRFTHwLAEIQRLAEREpvaavRDLIHGIdyESWLYETSPSPK 496
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 742 NG-----------------LGGSD-----------------DQIQRLESERNL--VQIVTIHKSKGLEYDLVFLpfvFSY 785
Cdd:PRK10919 497 AAemrmknvnqlfswmtemLEGSEldepmtltqvvtrftlrDMMERGESEEELdqVQLMTLHASKGLEFPYVYL---VGM 573
|
490 500 510 520
....*....|....*....|....*....|....*....|....*....
gi 758852163 786 REAseakyydaandrtvldITGNDASMkqaDKERLAEDLRLIYVALTRA 834
Cdd:PRK10919 574 EEG----------------LLPHQSSI---DEDNIDEERRLAYVGITRA 603
|
|
| helD |
PRK11054 |
DNA helicase IV; Provisional |
395-461 |
3.92e-05 |
|
DNA helicase IV; Provisional
Pssm-ID: 182930 [Multi-domain] Cd Length: 684 Bit Score: 48.02 E-value: 3.92e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 758852163 395 MIDEFQDTDPLQYSIFSRIYLNDPECGLFMIGDPKQAIYGFRGADI--FTYIKARNQVSAHYTLGTNWR 461
Cdd:PRK11054 435 LVDEFQDISPQRAALLAALRKQNSQTTLFAVGDDWQAIYRFSGADLslTTAFHERFGEGDRCHLDTTYR 503
|
|
| AAA_19 |
pfam13245 |
AAA domain; |
362-436 |
9.35e-05 |
|
AAA domain;
Pssm-ID: 433059 [Multi-domain] Cd Length: 136 Bit Score: 43.75 E-value: 9.35e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 758852163 362 LSFDDLLTqlsASIDTDESELLAARirtlypVAMIDEFQDTD-PLQYSIFSRIYlndPECGLFMIGDPKQAIYGFR 436
Cdd:pfam13245 73 LGFDDLEA---GGFLRDEEEPLDGD------LLIVDEFSMVDlPLAYRLLKALP---DGAQLLLVGDPDQLPSVGP 136
|
|
| HelD |
COG3973 |
DNA helicase IV [Replication, recombination and repair]; |
761-835 |
1.19e-03 |
|
DNA helicase IV [Replication, recombination and repair];
Pssm-ID: 443173 [Multi-domain] Cd Length: 699 Bit Score: 43.31 E-value: 1.19e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 758852163 761 VQIVTIHKSKGLEYDLVFLPfvfsyreaseakyydaandrtvlditgnDASMKQADKERlaeDLRLIYVALTRAV 835
Cdd:COG3973 639 VVVLPAYLAKGLEFDAVVVV----------------------------DPDEIVYESPR---GRRLLYVALTRAT 682
|
|
| AAA_19 |
pfam13245 |
AAA domain; |
34-136 |
1.55e-03 |
|
AAA domain;
Pssm-ID: 433059 [Multi-domain] Cd Length: 136 Bit Score: 39.89 E-value: 1.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 34 LIEASAGTGKTFTIAGLYLRLLLGHGSAetrhrvpltvDQILVVTFTEAATAELRDRIRARIHdariAFARGQSSDPVIQ 113
Cdd:pfam13245 15 LLTGGPGTGKTTTIRHIVALLVALGGVS----------FPILLAAPTGRAAKRLSERTGLPAS----TIHRLLGFDDLEA 80
|
90 100
....*....|....*....|...
gi 758852163 114 PLLNEFDDHKQAAEILLQAERQM 136
Cdd:pfam13245 81 GGFLRDEEEPLDGDLLIVDEFSM 103
|
|
| PDDEXK_1 |
pfam12705 |
PD-(D/E)XK nuclease superfamily; Members of this family belong to the PD-(D/E)XK nuclease ... |
984-1179 |
1.74e-03 |
|
PD-(D/E)XK nuclease superfamily; Members of this family belong to the PD-(D/E)XK nuclease superfamily
Pssm-ID: 432731 [Multi-domain] Cd Length: 250 Bit Score: 41.75 E-value: 1.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 984 GTFLHSLFEEIeftqpatteentqIILGLMESEQLDEewlpILQQLIDTVLVTPLDGKSLLLNQKAPSQRLVEMEFLLpi 1063
Cdd:pfam12705 37 GTLVHAALERF-------------YRWGRLPEEDLEE----LLQALLEELWPELGLQSEILPRLPWLAGRLRRRLERM-- 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 1064 evlsAPALNRVIQRHDPLSAKAGDLGFQTVQGMLKGFIDLV-FEHQGKYYVLDWKSnhlgddvthyhGEALKSAMADH-R 1141
Cdd:pfam12705 98 ----LRRLAEWLRARRGFRPVAVELGFGGTTVRLVGRIDRVdLDGEGYLRIIDYKT-----------GSAPPQSEDLDlY 162
|
170 180 190
....*....|....*....|....*....|....*...
gi 758852163 1142 YDLQYQIYALALHRflrsrlaNYQYEQHFGGVYYLFLR 1179
Cdd:pfam12705 163 EGLQLLLYLLALAA-------GEKALGGPAGALYLRLD 193
|
|
| AAA_25 |
pfam13481 |
AAA domain; This AAA domain is found in a wide variety of presumed DNA repair proteins. |
12-126 |
3.85e-03 |
|
AAA domain; This AAA domain is found in a wide variety of presumed DNA repair proteins.
Pssm-ID: 463892 [Multi-domain] Cd Length: 193 Bit Score: 40.06 E-value: 3.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758852163 12 DRTEQPQPTPLEPMTFPLHGARLIEASAGTGKTFTIAGLYLRLLLGHGSAETRHRV-PLTVdqiLVVTFtEAATAELRDR 90
Cdd:pfam13481 15 LAAPPPPRRWLIKGLLPAGGLGLLAGAPGTGKTTLALDLAAAVATGKPWLGGPRVPeQGKV---LYVSA-EGPADELRRR 90
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 758852163 91 IRA----RIHDARIAFARGQSSDPVIQ-----PLLNEFDDHKQAA 126
Cdd:pfam13481 91 LRAagadLDLPARLLFLSLVESLPLFFldrggPLLDADVDALEAA 135
|
|
| |
