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Conserved domains on  [gi|757741561|ref|WP_042965269|]
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cell envelope integrity protein TolA [Escherichia coli]

Protein Classification

cell envelope integrity protein TolA( domain architecture ID 11484310)

cell envelope integrity protein TolA is part of the Tol-Pal system that plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 1-379 1.03e-100

cell envelope integrity inner membrane protein TolA; Provisional


:

Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 303.27  E-value: 1.03e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757741561   1 MSKATEQNDKLKRAIIISAVLHVILFAALIWSSFDENIEASAGGGGGSSIDAVMVDSGAVVEQYKRMQSQESSAKRSDEQ 80
Cdd:PRK09510   1 MSKATEQNDKLKRAIIISVVLHIILFALLIWSSFDENIEASGGGGGGSVIDAVMVDPGAVVEQYNRQQQQQKSAKRAEEQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757741561  81 RKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKQAEEAA-------KQAELKQKQAEEAAAKAAADAKAKAEADA 153
Cdd:PRK09510  81 RKKKEQQQAEELQQKQAAEQERLKQLEKERLAAQEQKKQAEEAAkqaalkqKQAEEAAAKAAAAAKAKAEAEAKRAAAAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757741561 154 KAAEEAAKKAAADAKKKAEAEAAKAAAEAQKKAEAAAAALKKKAEAAEAAAAEARKKAATEAAEKAKAEAEKKAAAEKAA 233
Cdd:PRK09510 161 KKAAAEAKKKAEAEAAKKAAAEAKKKAEAEAAAKAAAEAKKKAEAEAKKKAAAEAKKKAAAEAKAAAAKAAAEAKAAAEK 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757741561 234 ADKKAAAEKAAAAKAAAEADDIFGELSSGKNAPKTGGGAKGNNASPAGSGNTKNNGASGADINNYAGQIKSAIESKFYDA 313
Cdd:PRK09510 241 AAAAKAAEKAAAAKAAAEVDDLFGGLDSGKNAPKTGGGAKGNGAQGAGAGNGKKGGASGADIDQYAGQIKSAIQSKFYDA 320

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 757741561 314 SSYAGKTCTLRIKLAPDGMLLDIKPEGGDPALCQAALAAAKLAKIPKPPSQAVYEVFKNAPLDFKP 379
Cdd:PRK09510 321 SSYAGKTCTLRIKLAPDGTLLDIKKEGGDPALCQAALAAAKTAKIPKPPSQEVYEKFKNAPLDFKP 386
 
Name Accession Description Interval E-value
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 1-379 1.03e-100

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 303.27  E-value: 1.03e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757741561   1 MSKATEQNDKLKRAIIISAVLHVILFAALIWSSFDENIEASAGGGGGSSIDAVMVDSGAVVEQYKRMQSQESSAKRSDEQ 80
Cdd:PRK09510   1 MSKATEQNDKLKRAIIISVVLHIILFALLIWSSFDENIEASGGGGGGSVIDAVMVDPGAVVEQYNRQQQQQKSAKRAEEQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757741561  81 RKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKQAEEAA-------KQAELKQKQAEEAAAKAAADAKAKAEADA 153
Cdd:PRK09510  81 RKKKEQQQAEELQQKQAAEQERLKQLEKERLAAQEQKKQAEEAAkqaalkqKQAEEAAAKAAAAAKAKAEAEAKRAAAAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757741561 154 KAAEEAAKKAAADAKKKAEAEAAKAAAEAQKKAEAAAAALKKKAEAAEAAAAEARKKAATEAAEKAKAEAEKKAAAEKAA 233
Cdd:PRK09510 161 KKAAAEAKKKAEAEAAKKAAAEAKKKAEAEAAAKAAAEAKKKAEAEAKKKAAAEAKKKAAAEAKAAAAKAAAEAKAAAEK 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757741561 234 ADKKAAAEKAAAAKAAAEADDIFGELSSGKNAPKTGGGAKGNNASPAGSGNTKNNGASGADINNYAGQIKSAIESKFYDA 313
Cdd:PRK09510 241 AAAAKAAEKAAAAKAAAEVDDLFGGLDSGKNAPKTGGGAKGNGAQGAGAGNGKKGGASGADIDQYAGQIKSAIQSKFYDA 320

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 757741561 314 SSYAGKTCTLRIKLAPDGMLLDIKPEGGDPALCQAALAAAKLAKIPKPPSQAVYEVFKNAPLDFKP 379
Cdd:PRK09510 321 SSYAGKTCTLRIKLAPDGTLLDIKKEGGDPALCQAALAAAKTAKIPKPPSQEVYEKFKNAPLDFKP 386
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 12-379 6.04e-41

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 147.30  E-value: 6.04e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757741561   12 KRAIIISAVLHVILFAALIWSSFDENIEASAGGGGGSsIDAVMVDSGAVVEQYKRMQSQESSAKRSDEQRKMKEQQAAEE 91
Cdd:TIGR02794   1 RRAFLLSLLLHILLLGLLILGSLYHSVKPEPGGGAEI-IQAVLVDPGAVAQQANRIQQQKKPAAKKEQERQKKLEQQAEE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757741561   92 LREKQAAEQERLKQLeKERLAAQEQKKQAEEAAKQAELkqkqaEEAAAKAAADAKAKAEADAKAAEEAAKKAAADAKKKA 171
Cdd:TIGR02794  80 AEKQRAAEQARQKEL-EQRAAAEKAAKQAEQAAKQAEE-----KQKQAEEAKAKQAAEAKAKAEAEAERKAKEEAAKQAE 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757741561  172 EAEAAKAAAEAQKKAEAAAAALKKKAEAAEAAAAEARKKAATEAAEKAKAEAEKKAAAEKAAADKKAAAEKAAAAKAAAE 251
Cdd:TIGR02794 154 EEAKAKAAAEAKKKAEEAKKKAEAEAKAKAEAEAKAKAEEAKAKAEAAKAKAAAEAAAKAEAEAAAAAAAEAERKADEAE 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757741561  252 ADDIFGeLSSGKNAPKTGGGAKgnnaspagsgntknnGASGADINNYAGQIKSAIESKFYDASSYAGKTCTLRIKLAPDG 331
Cdd:TIGR02794 234 LGDIFG-LASGSNAEKQGGARG---------------AAAGSEVDKYAAIIQQAIQQNLYDDPSFRGKTCRLRIRLAPDG 297

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 757741561  332 MLLDIKPEGGDPALCQAALA-AAKLAKIPKPPSQAVYEVFKNAPLDFKP 379
Cdd:TIGR02794 298 TLLSVTKSSGDPALCQAALAaVAKAAKLPMPPSDPVYEEFKNINLTFKP 346
TolA pfam06519
TolA C-terminal; This family consists of several bacterial TolA proteins as well as two ...
 285-377 4.10e-40

TolA C-terminal; This family consists of several bacterial TolA proteins as well as two eukaryotic proteins of unknown function. Tol proteins are involved in the translocation of group A colicins. Colicins are bacterial protein toxins, which are active against Escherichia coli and other related species (See pfam01024). TolA is anchored to the cytoplasmic membrane by a single membrane spanning segment near the N-terminus, leaving most of the protein exposed to the periplasm.


Pssm-ID: 399492 [Multi-domain]  Cd Length: 94  Bit Score: 137.17  E-value: 4.10e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757741561  285 TKNNGASGADINNYAGQIKSAIESKFYDASSYAGKTCTLRIKLAPDGMLLDIKPEGGDPALCQAALAA-AKLAKIPKPPS 363
Cdd:pfam06519   1 AAGSGASGAEVDRYAGQIKQAIQSRFLKDDSFAGKTCRVRIKLAPDGTLISVKVEGGDPALCQAAKAAvAKTAKIPKPPS 80

                          90
                  ....*....|....
gi 757741561  364 QAVYEVFKNAPLDF 377
Cdd:pfam06519  81 QDVYEKFKNINLDF 94
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
62-128 7.64e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 41.68  E-value: 7.64e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 757741561  62 EQYKRMQSQESSAKRSDEQRKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAE 128
Cdd:COG4717  153 ERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQ 219
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 59-129 8.20e-03

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 37.56  E-value: 8.20e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 757741561  59 AVVEQYkrMQSQESSAK---RSDEQRKMKEQQAAEELREKQAAEQERlkQLEKERLAAQEQKKQAEEAAKQAEL 129
Cdd:cd16269  170 EVLQEF--LQSKEAEAEailQADQALTEKEKEIEAERAKAEAAEQER--KLLEEQQRELEQKLEDQERSYEEHL 239
 
Name Accession Description Interval E-value
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 1-379 1.03e-100

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 303.27  E-value: 1.03e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757741561   1 MSKATEQNDKLKRAIIISAVLHVILFAALIWSSFDENIEASAGGGGGSSIDAVMVDSGAVVEQYKRMQSQESSAKRSDEQ 80
Cdd:PRK09510   1 MSKATEQNDKLKRAIIISVVLHIILFALLIWSSFDENIEASGGGGGGSVIDAVMVDPGAVVEQYNRQQQQQKSAKRAEEQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757741561  81 RKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKQAEEAA-------KQAELKQKQAEEAAAKAAADAKAKAEADA 153
Cdd:PRK09510  81 RKKKEQQQAEELQQKQAAEQERLKQLEKERLAAQEQKKQAEEAAkqaalkqKQAEEAAAKAAAAAKAKAEAEAKRAAAAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757741561 154 KAAEEAAKKAAADAKKKAEAEAAKAAAEAQKKAEAAAAALKKKAEAAEAAAAEARKKAATEAAEKAKAEAEKKAAAEKAA 233
Cdd:PRK09510 161 KKAAAEAKKKAEAEAAKKAAAEAKKKAEAEAAAKAAAEAKKKAEAEAKKKAAAEAKKKAAAEAKAAAAKAAAEAKAAAEK 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757741561 234 ADKKAAAEKAAAAKAAAEADDIFGELSSGKNAPKTGGGAKGNNASPAGSGNTKNNGASGADINNYAGQIKSAIESKFYDA 313
Cdd:PRK09510 241 AAAAKAAEKAAAAKAAAEVDDLFGGLDSGKNAPKTGGGAKGNGAQGAGAGNGKKGGASGADIDQYAGQIKSAIQSKFYDA 320

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 757741561 314 SSYAGKTCTLRIKLAPDGMLLDIKPEGGDPALCQAALAAAKLAKIPKPPSQAVYEVFKNAPLDFKP 379
Cdd:PRK09510 321 SSYAGKTCTLRIKLAPDGTLLDIKKEGGDPALCQAALAAAKTAKIPKPPSQEVYEKFKNAPLDFKP 386
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 12-379 6.04e-41

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 147.30  E-value: 6.04e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757741561   12 KRAIIISAVLHVILFAALIWSSFDENIEASAGGGGGSsIDAVMVDSGAVVEQYKRMQSQESSAKRSDEQRKMKEQQAAEE 91
Cdd:TIGR02794   1 RRAFLLSLLLHILLLGLLILGSLYHSVKPEPGGGAEI-IQAVLVDPGAVAQQANRIQQQKKPAAKKEQERQKKLEQQAEE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757741561   92 LREKQAAEQERLKQLeKERLAAQEQKKQAEEAAKQAELkqkqaEEAAAKAAADAKAKAEADAKAAEEAAKKAAADAKKKA 171
Cdd:TIGR02794  80 AEKQRAAEQARQKEL-EQRAAAEKAAKQAEQAAKQAEE-----KQKQAEEAKAKQAAEAKAKAEAEAERKAKEEAAKQAE 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757741561  172 EAEAAKAAAEAQKKAEAAAAALKKKAEAAEAAAAEARKKAATEAAEKAKAEAEKKAAAEKAAADKKAAAEKAAAAKAAAE 251
Cdd:TIGR02794 154 EEAKAKAAAEAKKKAEEAKKKAEAEAKAKAEAEAKAKAEEAKAKAEAAKAKAAAEAAAKAEAEAAAAAAAEAERKADEAE 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757741561  252 ADDIFGeLSSGKNAPKTGGGAKgnnaspagsgntknnGASGADINNYAGQIKSAIESKFYDASSYAGKTCTLRIKLAPDG 331
Cdd:TIGR02794 234 LGDIFG-LASGSNAEKQGGARG---------------AAAGSEVDKYAAIIQQAIQQNLYDDPSFRGKTCRLRIRLAPDG 297

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 757741561  332 MLLDIKPEGGDPALCQAALA-AAKLAKIPKPPSQAVYEVFKNAPLDFKP 379
Cdd:TIGR02794 298 TLLSVTKSSGDPALCQAALAaVAKAAKLPMPPSDPVYEEFKNINLTFKP 346
TolA pfam06519
TolA C-terminal; This family consists of several bacterial TolA proteins as well as two ...
 285-377 4.10e-40

TolA C-terminal; This family consists of several bacterial TolA proteins as well as two eukaryotic proteins of unknown function. Tol proteins are involved in the translocation of group A colicins. Colicins are bacterial protein toxins, which are active against Escherichia coli and other related species (See pfam01024). TolA is anchored to the cytoplasmic membrane by a single membrane spanning segment near the N-terminus, leaving most of the protein exposed to the periplasm.


Pssm-ID: 399492 [Multi-domain]  Cd Length: 94  Bit Score: 137.17  E-value: 4.10e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757741561  285 TKNNGASGADINNYAGQIKSAIESKFYDASSYAGKTCTLRIKLAPDGMLLDIKPEGGDPALCQAALAA-AKLAKIPKPPS 363
Cdd:pfam06519   1 AAGSGASGAEVDRYAGQIKQAIQSRFLKDDSFAGKTCRVRIKLAPDGTLISVKVEGGDPALCQAAKAAvAKTAKIPKPPS 80

                          90
                  ....*....|....
gi 757741561  364 QAVYEVFKNAPLDF 377
Cdd:pfam06519  81 QDVYEKFKNINLDF 94
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
62-128 7.64e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 41.68  E-value: 7.64e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 757741561  62 EQYKRMQSQESSAKRSDEQRKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAE 128
Cdd:COG4717  153 ERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQ 219
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 68-129 1.49e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 40.69  E-value: 1.49e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 757741561  68 QSQESSAKRSDEQRKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAEL 129
Cdd:COG1196  297 LARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEA 358
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 62-128 1.96e-03

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 40.32  E-value: 1.96e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 757741561   62 EQYKRMQSQESSAKRSDEQRKMKEQQAAEELR-EKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAE 128
Cdd:pfam15709 359 EQRRLQQEQLERAEKMREELELEQQRRFEEIRlRKQRLEEERQRQEEEERKQRLQLQAAQERARQQQE 426
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 62-127 2.97e-03

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 39.55  E-value: 2.97e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 757741561   62 EQYKRMQSQESSAKRSDEQRKMKE---QQAAEELREKQAAEQERLKQL-------EKERLAAQEQKKQAEEAAKQA 127
Cdd:pfam15709 433 QELQRKKQQEEAERAEAEKQRQKElemQLAEEQKRLMEMAEEERLEYQrqkqeaeEKARLEAEERRQKEEEAARLA 508
CCDC47 pfam07946
PAT complex subunit CCDC47; This family represents CCDC47 proteins which are a component of ...
 76-127 3.55e-03

PAT complex subunit CCDC47; This family represents CCDC47 proteins which are a component of the PAT complex, an endoplasmic reticulum (ER)-resident membrane multiprotein complex that facilitates multi-pass membrane proteins insertion into membranes. The PAT complex, formed by CCDC47 and Asterix proteins, acts as an intramembrane chaperone by directly interacting with nascent transmembrane domains (TMDs), releasing its substrates upon correct folding, and is needed for optimal biogenesis of multi-pass membrane proteins. CCDC47 is required to maintain the stability of Asterix. CCDC47 is associated with various membrane-associated processes and is component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. It is also involved in the regulation of calcium ion homeostasis in the ER, being also required for proper protein degradation via the ERAD (ER-associated degradation) pathway.


Pssm-ID: 462322  Cd Length: 323  Bit Score: 39.09  E-value: 3.55e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 757741561   76 RSDEQ---RKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKQAE-EAAKQA 127
Cdd:pfam07946 266 REEEIekiKKAAEEERAEEAQEKKEEAKKKEREEKLAKLSPEEQRKYEEkERKKEQ 321
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 62-129 3.55e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.53  E-value: 3.55e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 757741561  62 EQYKRMQSQESSAKRSDEQRKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAEL 129
Cdd:COG1196  417 ERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLE 484
PTZ00121 PTZ00121
MAEBL; Provisional
 61-128 3.62e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 39.74  E-value: 3.62e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 757741561   61 VEQYKRMQSQESSAKRSDEQ-RKMKEQQAAEELREK--QAAEQERLKQLEKERLAAQEQKKQAEEAAKQAE 128
Cdd:PTZ00121 1430 KKKADEAKKKAEEAKKADEAkKKAEEAKKAEEAKKKaeEAKKADEAKKKAEEAKKADEAKKKAEEAKKKAD 1500
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 68-129 4.37e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.15  E-value: 4.37e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 757741561  68 QSQESSAKRSDEQRKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAEL 129
Cdd:COG1196  381 LEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEE 442
hsdR PRK11448
type I restriction enzyme EcoKI subunit R; Provisional
 60-127 5.48e-03

type I restriction enzyme EcoKI subunit R; Provisional


Pssm-ID: 236912 [Multi-domain]  Cd Length: 1123  Bit Score: 38.78  E-value: 5.48e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 757741561   60 VVEQYKRMQSQESSAKRSDEQRKMKEQQAAEeLREKQAAEQERLKQLEKERLAA-QEQKKQAEEAAKQA 127
Cdd:PRK11448  158 LELQAREKAQSQALAEAQQQELVALEGLAAE-LEEKQQELEAQLEQLQEKAAETsQERKQKRKEITDQA 225
PTZ00121 PTZ00121
MAEBL; Provisional
 67-129 5.66e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 38.97  E-value: 5.66e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 757741561   67 MQSQESSAKRSDE-QRKMKEQQAAEELREK--QAAEQERLKQLEKERLAAQEQKKQAEEAAKQAEL 129
Cdd:PTZ00121 1410 LKKAAAAKKKADEaKKKAEEKKKADEAKKKaeEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEA 1475
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 63-129 6.93e-03

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 38.39  E-value: 6.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757741561   63 QYKRMQSQESSAKRSDEQRKMKEQQAAEE---------------LREKQAAEQERLKQLEKERLAAQEQKKQA-EEAAKQ 126
Cdd:pfam15709 436 QRKKQQEEAERAEAEKQRQKELEMQLAEEqkrlmemaeeerleyQRQKQEAEEKARLEAEERRQKEEEAARLAlEEAMKQ 515


                  ...
gi 757741561  127 AEL 129
Cdd:pfam15709 516 AQE 518
Radial_spoke_3 pfam06098
Radial spoke protein 3; This family consists of several radial spoke protein 3 (RSP3) ...
 78-126 7.55e-03

Radial spoke protein 3; This family consists of several radial spoke protein 3 (RSP3) sequences. Eukaryotic cilia and flagella present in diverse types of cells perform motile, sensory, and developmental functions in organizms from protists to humans. They are centred by precisely organized, microtubule-based structures, the axonemes. The axoneme consists of two central singlet microtubules, called the central pair, and nine outer doublet microtubules. These structures are well-conserved during evolution. The outer doublet microtubules, each composed of A and B sub-fibres, are connected to each other by nexin links, while the central pair is held at the centre of the axoneme by radial spokes. The radial spokes are T-shaped structures extending from the A-tubule of each outer doublet microtubule to the centre of the axoneme. Radial spoke protein 3 (RSP3), is present at the proximal end of the spoke stalk and helps in anchoring the radial spoke to the outer doublet. It is thought that radial spokes regulate the activity of inner arm dynein through protein phosphorylation and dephosphorylation.


Pssm-ID: 461827  Cd Length: 286  Bit Score: 38.00  E-value: 7.55e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 757741561   78 DEQRKMKEQQAA-EELREKQAAEQERL------KQLEKERLAAQ--EQKKQAEEAAKQ 126
Cdd:pfam06098 153 EELANLREQQRAfEELRNAELAEVQRLeeqerrLREEKERRIAQqrEALKKEKETAEK 210
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 61-129 7.79e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 38.18  E-value: 7.79e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 757741561   61 VEQYKRMQSQESSAKRSDEQRKMKEQQAAEELR-EKQA---AEQERL---KQLEKERLaAQEQKKQAEEAAKQAEL 129
Cdd:pfam17380 296 MEQERLRQEKEEKAREVERRRKLEEAEKARQAEmDRQAaiyAEQERMameRERELERI-RQEERKRELERIRQEEI 370
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 59-129 8.20e-03

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 37.56  E-value: 8.20e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 757741561  59 AVVEQYkrMQSQESSAK---RSDEQRKMKEQQAAEELREKQAAEQERlkQLEKERLAAQEQKKQAEEAAKQAEL 129
Cdd:cd16269  170 EVLQEF--LQSKEAEAEailQADQALTEKEKEIEAERAKAEAAEQER--KLLEEQQRELEQKLEDQERSYEEHL 239
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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