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Conserved domains on  [gi|757682115|ref|WP_042912646|]
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gamma-glutamyltransferase [Pseudomonas aeruginosa]

Protein Classification

gamma-glutamyltransferase family protein( domain architecture ID 10470232)

gamma-glutamyltransferase family protein exhibits gamma-glutamyltranspeptidase and/or cephalosporin acylase and/or glutathione hydrolase activity, all involving the hydrolytic splitting of a peptide-like C-N bond

EC:  3.-.-.-
Gene Ontology:  GO:0016787
MEROPS:  T3
PubMed:  11563810|22527720
SCOP:  4000420

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
G_glu_transpept pfam01019
Gamma-glutamyltranspeptidase;
98-562 2.62e-179

Gamma-glutamyltranspeptidase;


:

Pssm-ID: 425991  Cd Length: 499  Bit Score: 515.61  E-value: 2.62e-179
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115   98 PTYRFLDARERAPKAAYADMYrrNGKVDPRLSVDGPLAAAIPGLPAALVELSSRYGRKPLADNLVPAIRLAVDGVSVDRI 177
Cdd:pfam01019  45 GKVLVIDARETAPAAATKDMF--DGKGDSKLSLTGGLAVGVPGEVAGLAEAHKRYGRLPWADLLEPAIKLARDGFPVSPA 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115  178 YRDRAAMRLEAMRKDPETARIFLDKGGIPDEWNLLRQPQLARTLERLGRYGRIGFYEGETADKLLTGVRAGGGIWSAADL 257
Cdd:pfam01019 123 LARALARAEERLRADPGLRKIFLPTGRVLKAGELLKQPALAKTLELIAEEGPDAFYRGELAQQLVADLQANGGIITAEDL 202
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115  258 RDYRVIERRPLEVKLanGRELISAPPPSAGGVALAQSLQMLEQLPWQK-AEPVQRAHYVLEVLRRAYRDRGL-LGDPDFV 335
Cdd:pfam01019 203 ANYRVKIREPLSADY--GGYTVYSPPPSSGGIALLQILNILEGFDLSSlLNSAEYLHLLIEAMKLAYADRTRyLGDPDFV 280
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115  336 ANPLPSLLAPDYLKRLAAGIDPRRATPSsalpeaPAWREGDHTTHFAVIDAQGNAVAATLSVNLPFGAAFTVPGTGVVLN 415
Cdd:pfam01019 281 PVPVENLLSPEYAKERAKLINPNAAFPS------SYAPEDGGTTHFSVVDRDGNAVSFTSTINLGFGSGVVVPGTGILLN 354
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115  416 NEMDDFAadTQGANSYGLAGSQANAVAAGKRPLSSMSPSFLES-PTDFAAFGTPGGSRIPSMVLISMLQYFD-GRPVGQW 493
Cdd:pfam01019 355 NEMDDFS--TPPGNAFGLDPSPANAIAPGKRPLSSMAPTIVLDdGKPVLVVGAPGGSRIISAVLQVIVNVLDlGLDLQQA 432
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 757682115  494 VAAPRYHHQYkPDVVEYEPRaFSDAEAAELRRRGYQLKRLERSYGNQQVLYWDKRSGRVDAASDPRGIG 562
Cdd:pfam01019 433 VDAPRIHHQL-PDVLEVEPG-FPEEVLAELEARGHKVKVVEDSSSVGAIQIVRRTGGVLYAASDPRRDG 499
 
Name Accession Description Interval E-value
G_glu_transpept pfam01019
Gamma-glutamyltranspeptidase;
98-562 2.62e-179

Gamma-glutamyltranspeptidase;


Pssm-ID: 425991  Cd Length: 499  Bit Score: 515.61  E-value: 2.62e-179
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115   98 PTYRFLDARERAPKAAYADMYrrNGKVDPRLSVDGPLAAAIPGLPAALVELSSRYGRKPLADNLVPAIRLAVDGVSVDRI 177
Cdd:pfam01019  45 GKVLVIDARETAPAAATKDMF--DGKGDSKLSLTGGLAVGVPGEVAGLAEAHKRYGRLPWADLLEPAIKLARDGFPVSPA 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115  178 YRDRAAMRLEAMRKDPETARIFLDKGGIPDEWNLLRQPQLARTLERLGRYGRIGFYEGETADKLLTGVRAGGGIWSAADL 257
Cdd:pfam01019 123 LARALARAEERLRADPGLRKIFLPTGRVLKAGELLKQPALAKTLELIAEEGPDAFYRGELAQQLVADLQANGGIITAEDL 202
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115  258 RDYRVIERRPLEVKLanGRELISAPPPSAGGVALAQSLQMLEQLPWQK-AEPVQRAHYVLEVLRRAYRDRGL-LGDPDFV 335
Cdd:pfam01019 203 ANYRVKIREPLSADY--GGYTVYSPPPSSGGIALLQILNILEGFDLSSlLNSAEYLHLLIEAMKLAYADRTRyLGDPDFV 280
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115  336 ANPLPSLLAPDYLKRLAAGIDPRRATPSsalpeaPAWREGDHTTHFAVIDAQGNAVAATLSVNLPFGAAFTVPGTGVVLN 415
Cdd:pfam01019 281 PVPVENLLSPEYAKERAKLINPNAAFPS------SYAPEDGGTTHFSVVDRDGNAVSFTSTINLGFGSGVVVPGTGILLN 354
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115  416 NEMDDFAadTQGANSYGLAGSQANAVAAGKRPLSSMSPSFLES-PTDFAAFGTPGGSRIPSMVLISMLQYFD-GRPVGQW 493
Cdd:pfam01019 355 NEMDDFS--TPPGNAFGLDPSPANAIAPGKRPLSSMAPTIVLDdGKPVLVVGAPGGSRIISAVLQVIVNVLDlGLDLQQA 432
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 757682115  494 VAAPRYHHQYkPDVVEYEPRaFSDAEAAELRRRGYQLKRLERSYGNQQVLYWDKRSGRVDAASDPRGIG 562
Cdd:pfam01019 433 VDAPRIHHQL-PDVLEVEPG-FPEEVLAELEARGHKVKVVEDSSSVGAIQIVRRTGGVLYAASDPRRDG 499
Ggt COG0405
Gamma-glutamyltranspeptidase [Amino acid transport and metabolism];
40-560 6.49e-168

Gamma-glutamyltranspeptidase [Amino acid transport and metabolism];


Pssm-ID: 440174  Cd Length: 507  Bit Score: 486.87  E-value: 6.49e-168
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115  40 AVATPHPAATVAGLETLANGGNafdaaaaiaaalavaEPygsglggggffllrQAG-------------AQPTYRFLDAR 106
Cdd:COG0405    1 MVATAHPLASQAGLEILRAGGNavdaavaaaaalavvEP--------------HSSgiggggfaliydaKDGKVTALDGR 66
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115 107 ERAPKAAYADMYRRNGKVDPrlsVDGPLAAAIPGLPAALVELSSRYGRKPLADNLVPAIRLAVDGVSVDRIYRDRAAMRL 186
Cdd:COG0405   67 GTAPAAATPDMYLDAGDEIP---VRGPLAVGVPGTVAGWEAAHERYGTLPLAELLAPAIRLAEDGFPVSPRLAALLAAAA 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115 187 EAMRKDPETARIFLDKGGIPDEWNLLRQPQLARTLERLGRYGRIGFYEGETADKLLTGVRAGGGIWSAADLRDYRVIERR 266
Cdd:COG0405  144 ERLARDPGAAAIFLPDGRPPKAGDILRQPDLAATLRRIAEEGADAFYRGEIAEAIVAAVQAAGGLLTLEDLAAYRAEWRE 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115 267 PLEVKLaNGRELISAPPPSAgGVALAQSLQMLEQLPWQKAEP--VQRAHYVLEVLRRAYRDRGL-LGDPDFVANPLPSLL 343
Cdd:COG0405  224 PLSGTY-RGYTVYSMPPPSQ-GIALLQILNILEGFDLAALGPdsAEYVHLLAEAMKLAFADRDRyLGDPDFVDVPVEGLL 301
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115 344 APDYLKRLAAGIDPRRATPsSALPEAPAWREGDHTTHFAVIDAQGNAVAATLSVNLPFGAAFTVPGTGVVLNNEMDDFAA 423
Cdd:COG0405  302 SPAYAAERAALIDPDRATP-SPRPGDPTGPESGDTTHLSVVDRDGNAVSLTQSIYGGFGSGVVVPGTGFLLNNRGDDFSL 380
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115 424 DTQGansyglagsqANAVAAGKRPLSSMSPSFLESP-TDFAAFGTPGGSRIPSMVLISMLQYFD-GRPVGQWVAAPRYHH 501
Cdd:COG0405  381 DPGH----------PNALAPGKRPRSTMSPTIVLKDgKPVLVFGSPGGSRIPQTVLQVLLNVLDfGMNPQEAVDAPRWHH 450
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 757682115 502 QYKPDVVEYEPRaFSDAEAAELRRRGYQLKRLERSYGNQQVLYWDkRSGRVDAASDPRG 560
Cdd:COG0405  451 QGLPDTLELEPR-FPPAVIAALRARGHKVEVVPDWSGGAQAILRD-PDGVLEGAADPRR 507
g_glut_trans TIGR00066
gamma-glutamyltranspeptidase; Also called gamma-glutamyltranspeptidase (ggt). Some members of ...
41-559 1.79e-103

gamma-glutamyltranspeptidase; Also called gamma-glutamyltranspeptidase (ggt). Some members of this family have antibiotic synthesis or resistance activities. In the case of a cephalosporin acylase from Pseudomonas sp., the enzyme was shown to retain some gamma-glutamyltranspeptidase activity. Other, more distantly related proteins have ggt-related activities and score below the trusted cutoff. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs]


Pssm-ID: 129176  Cd Length: 516  Bit Score: 321.72  E-value: 1.79e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115   41 VATPHPAATVAGLETLANGGNAFDAAAAIAAALAVAEPYGSGLGGGGFFLLRQAGAQPTYRFlDARERAPKAAYADMYR- 119
Cdd:TIGR00066   3 VASLHALASEIGEDILKEGGNAFDAAVAVGLALAVVEPFMTGLGGGGFMLISGKKTKDTTAI-DFRERAPAKATRDMFLd 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115  120 RNGKVDPRLSVDGPLAAAIPGLPAALVELSSRYGRKPLADNLVPAIRLAVDGVSVDRIYRDRAAMRLEAMRKDPETAR-I 198
Cdd:TIGR00066  82 KSGNPLPGKSLTGGLAIGVPGTVAGLEAALKKYGTLPLKDLIEPAIKLARNGFPINEALADTLELYEEVLLTTKEDSKdI 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115  199 FLDKGGIPDEWNLLRQPQLARTLERLGRYGRIGFYEGETADKLLTGVRAGGGIWSAADLRDYRVIERRPLEVKLaNGREL 278
Cdd:TIGR00066 162 FNPTGKPLKEGDTLVQKDLAKSLELIAENGPDAFYKGDIAESIIDTLQKNGGIMTKKDLAAYDVEIRKPLSGDY-RGYQV 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115  279 ISAPPPSAGGVALAQSLQMLE-----QLPWQKAEPVqraHYVLEVLRRAYRDRG-LLGDPDFVANPLPSLLAPDYLKRLA 352
Cdd:TIGR00066 241 YTTPPPSSGGIHLLQALNILEnfdlsQYGDGSAETY---QLLAEAMKLSYADRSrYLGDPEFVDVPLEELLDKRYAKELA 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115  353 AGIDPRRATPSSAL-PEAPAWREGDHTTHFAVIDAQGNAVAATLSVNLPFGAAFTVPGTGVVLNNEMDDFAADTQGansy 431
Cdd:TIGR00066 318 QSIKINKVDPKSTIyPGAYQPNEGSQTTHFSVVDRDGNAVSLTTTINLEFGSGVHAPDTGILLNNEMDDFSLKPGG---- 393
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115  432 glagsqANAVAAGKRPLSSMSPSFL---ESPtdFAAFGTPGGSRIPSMVLISMLQYFD-GRPVGQWVAAPRYHHQYKPDV 507
Cdd:TIGR00066 394 ------ANAVEPNKRPLSSMAPTIVlkdGKP--DLVVGSPGGSRIITTVLQTIVRHIDyGMPLAEAVSEPRIHHQWLPDE 465
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|...
gi 757682115  508 VEYEPRaFSDAEAAELRRRGYQLKRLE-RSYGNQQVLYWDkRSGRVDAASDPR 559
Cdd:TIGR00066 466 LRLEKG-FPDDVLQLLKDMGHKVTLKEvFPMGVVQAIRVD-PEGWLYGVSDPR 516
ggt PRK09615
gamma-glutamyltranspeptidase; Reviewed
37-561 4.08e-88

gamma-glutamyltranspeptidase; Reviewed


Pssm-ID: 181992  Cd Length: 581  Bit Score: 284.11  E-value: 4.08e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115  37 QQAAVATPHPAATVAGLETLANGGNAFDAAAAIAAALAVAEPYGSGLGGGGFFLLRQAGAQPTYrfLDARERAPKAAYAD 116
Cdd:PRK09615  48 KQGMVASVDATATQVGVDILKQGGNAVDAAVAVGYALAVTHPQAGNLGGGGFMLLRTKNGNTTA--IDFREMAPAKATRD 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115 117 MY-RRNGKVDPRLSVDGPLAAAIPGLPAALVELSSRYGRKPLADNLVPAIRLAVDGVSV-DRIYRDRAAMRLEAMRKDPE 194
Cdd:PRK09615 126 MFlDDQGNPDSKKSLTSHLASGTPGTVAGFSLALDKYGTMPLNKVVQPAFKLARDGFIVnDALADDLKTYGSEVLPNHEN 205
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115 195 TARIFLDKGGIPDEWNLLRQPQLARTLERLGRYGRIGFYEGETADKLLTGVRAGGGIWSAADLRDYRVIERRPLEVKLaN 274
Cdd:PRK09615 206 SKAIFWKEGEPLKKGDKLVQANLAKSLEMIAENGPDAFYKGTIADQIAQEMQKNGGLITKEDLAAYKAVERTPISGDY-R 284
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115 275 GRELISAPPPSAGGVALAQSLQMLEQLPWQK-----AEPVQrahYVLEVLRRAYRDRG-LLGDPDFVANPLPSLLAPDYL 348
Cdd:PRK09615 285 GYQVYSMPPPSSGGIHIVQILNILENFDMKKygfgsADAMQ---IMAEAEKYAYADRSeYLGDPDFVKVPWQALTNKAYA 361
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115 349 KRLAAGIDPRRATPSSAL-PEAPAWREGDHTTHFAVIDAQGNAVAATLSVNLPFGAAFTVPGTGVVLNNEMDDFAADTQG 427
Cdd:PRK09615 362 KSIADQIDINKAKPSSEIrPGKLAPYESNQTTHFSVVDKDGNAVAVTYTLNTTFGTGIVAGNSGILLNNQMDDFSAKPGV 441
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115 428 ANSYGLAGSQANAVAAGKRPLSSMSPSFL-ESPTDFAAFGTPGGSRIPSMVLISMLQYFD-GRPVGQWVAAPRYHHQYKP 505
Cdd:PRK09615 442 PNVYGLVGGDANAVGPNKRPLSSMSPTIVvKDGKTWLVTGSPGGSRIITTVLQMVVNSIDyGMNVAEATNAPRFHHQWLP 521
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 757682115 506 DVVEYEpRAFSDAEAAELRRRGYQLKRLERSYGNQQVLYwdKRSGRVDAASDPRGI 561
Cdd:PRK09615 522 DELRVE-KGFSPDTLKLLEAKGQKVALKEAMGSTQSIMV--GPDGELYGASDPRSV 574
 
Name Accession Description Interval E-value
G_glu_transpept pfam01019
Gamma-glutamyltranspeptidase;
98-562 2.62e-179

Gamma-glutamyltranspeptidase;


Pssm-ID: 425991  Cd Length: 499  Bit Score: 515.61  E-value: 2.62e-179
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115   98 PTYRFLDARERAPKAAYADMYrrNGKVDPRLSVDGPLAAAIPGLPAALVELSSRYGRKPLADNLVPAIRLAVDGVSVDRI 177
Cdd:pfam01019  45 GKVLVIDARETAPAAATKDMF--DGKGDSKLSLTGGLAVGVPGEVAGLAEAHKRYGRLPWADLLEPAIKLARDGFPVSPA 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115  178 YRDRAAMRLEAMRKDPETARIFLDKGGIPDEWNLLRQPQLARTLERLGRYGRIGFYEGETADKLLTGVRAGGGIWSAADL 257
Cdd:pfam01019 123 LARALARAEERLRADPGLRKIFLPTGRVLKAGELLKQPALAKTLELIAEEGPDAFYRGELAQQLVADLQANGGIITAEDL 202
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115  258 RDYRVIERRPLEVKLanGRELISAPPPSAGGVALAQSLQMLEQLPWQK-AEPVQRAHYVLEVLRRAYRDRGL-LGDPDFV 335
Cdd:pfam01019 203 ANYRVKIREPLSADY--GGYTVYSPPPSSGGIALLQILNILEGFDLSSlLNSAEYLHLLIEAMKLAYADRTRyLGDPDFV 280
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115  336 ANPLPSLLAPDYLKRLAAGIDPRRATPSsalpeaPAWREGDHTTHFAVIDAQGNAVAATLSVNLPFGAAFTVPGTGVVLN 415
Cdd:pfam01019 281 PVPVENLLSPEYAKERAKLINPNAAFPS------SYAPEDGGTTHFSVVDRDGNAVSFTSTINLGFGSGVVVPGTGILLN 354
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115  416 NEMDDFAadTQGANSYGLAGSQANAVAAGKRPLSSMSPSFLES-PTDFAAFGTPGGSRIPSMVLISMLQYFD-GRPVGQW 493
Cdd:pfam01019 355 NEMDDFS--TPPGNAFGLDPSPANAIAPGKRPLSSMAPTIVLDdGKPVLVVGAPGGSRIISAVLQVIVNVLDlGLDLQQA 432
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 757682115  494 VAAPRYHHQYkPDVVEYEPRaFSDAEAAELRRRGYQLKRLERSYGNQQVLYWDKRSGRVDAASDPRGIG 562
Cdd:pfam01019 433 VDAPRIHHQL-PDVLEVEPG-FPEEVLAELEARGHKVKVVEDSSSVGAIQIVRRTGGVLYAASDPRRDG 499
Ggt COG0405
Gamma-glutamyltranspeptidase [Amino acid transport and metabolism];
40-560 6.49e-168

Gamma-glutamyltranspeptidase [Amino acid transport and metabolism];


Pssm-ID: 440174  Cd Length: 507  Bit Score: 486.87  E-value: 6.49e-168
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115  40 AVATPHPAATVAGLETLANGGNafdaaaaiaaalavaEPygsglggggffllrQAG-------------AQPTYRFLDAR 106
Cdd:COG0405    1 MVATAHPLASQAGLEILRAGGNavdaavaaaaalavvEP--------------HSSgiggggfaliydaKDGKVTALDGR 66
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115 107 ERAPKAAYADMYRRNGKVDPrlsVDGPLAAAIPGLPAALVELSSRYGRKPLADNLVPAIRLAVDGVSVDRIYRDRAAMRL 186
Cdd:COG0405   67 GTAPAAATPDMYLDAGDEIP---VRGPLAVGVPGTVAGWEAAHERYGTLPLAELLAPAIRLAEDGFPVSPRLAALLAAAA 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115 187 EAMRKDPETARIFLDKGGIPDEWNLLRQPQLARTLERLGRYGRIGFYEGETADKLLTGVRAGGGIWSAADLRDYRVIERR 266
Cdd:COG0405  144 ERLARDPGAAAIFLPDGRPPKAGDILRQPDLAATLRRIAEEGADAFYRGEIAEAIVAAVQAAGGLLTLEDLAAYRAEWRE 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115 267 PLEVKLaNGRELISAPPPSAgGVALAQSLQMLEQLPWQKAEP--VQRAHYVLEVLRRAYRDRGL-LGDPDFVANPLPSLL 343
Cdd:COG0405  224 PLSGTY-RGYTVYSMPPPSQ-GIALLQILNILEGFDLAALGPdsAEYVHLLAEAMKLAFADRDRyLGDPDFVDVPVEGLL 301
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115 344 APDYLKRLAAGIDPRRATPsSALPEAPAWREGDHTTHFAVIDAQGNAVAATLSVNLPFGAAFTVPGTGVVLNNEMDDFAA 423
Cdd:COG0405  302 SPAYAAERAALIDPDRATP-SPRPGDPTGPESGDTTHLSVVDRDGNAVSLTQSIYGGFGSGVVVPGTGFLLNNRGDDFSL 380
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115 424 DTQGansyglagsqANAVAAGKRPLSSMSPSFLESP-TDFAAFGTPGGSRIPSMVLISMLQYFD-GRPVGQWVAAPRYHH 501
Cdd:COG0405  381 DPGH----------PNALAPGKRPRSTMSPTIVLKDgKPVLVFGSPGGSRIPQTVLQVLLNVLDfGMNPQEAVDAPRWHH 450
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 757682115 502 QYKPDVVEYEPRaFSDAEAAELRRRGYQLKRLERSYGNQQVLYWDkRSGRVDAASDPRG 560
Cdd:COG0405  451 QGLPDTLELEPR-FPPAVIAALRARGHKVEVVPDWSGGAQAILRD-PDGVLEGAADPRR 507
g_glut_trans TIGR00066
gamma-glutamyltranspeptidase; Also called gamma-glutamyltranspeptidase (ggt). Some members of ...
41-559 1.79e-103

gamma-glutamyltranspeptidase; Also called gamma-glutamyltranspeptidase (ggt). Some members of this family have antibiotic synthesis or resistance activities. In the case of a cephalosporin acylase from Pseudomonas sp., the enzyme was shown to retain some gamma-glutamyltranspeptidase activity. Other, more distantly related proteins have ggt-related activities and score below the trusted cutoff. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs]


Pssm-ID: 129176  Cd Length: 516  Bit Score: 321.72  E-value: 1.79e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115   41 VATPHPAATVAGLETLANGGNAFDAAAAIAAALAVAEPYGSGLGGGGFFLLRQAGAQPTYRFlDARERAPKAAYADMYR- 119
Cdd:TIGR00066   3 VASLHALASEIGEDILKEGGNAFDAAVAVGLALAVVEPFMTGLGGGGFMLISGKKTKDTTAI-DFRERAPAKATRDMFLd 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115  120 RNGKVDPRLSVDGPLAAAIPGLPAALVELSSRYGRKPLADNLVPAIRLAVDGVSVDRIYRDRAAMRLEAMRKDPETAR-I 198
Cdd:TIGR00066  82 KSGNPLPGKSLTGGLAIGVPGTVAGLEAALKKYGTLPLKDLIEPAIKLARNGFPINEALADTLELYEEVLLTTKEDSKdI 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115  199 FLDKGGIPDEWNLLRQPQLARTLERLGRYGRIGFYEGETADKLLTGVRAGGGIWSAADLRDYRVIERRPLEVKLaNGREL 278
Cdd:TIGR00066 162 FNPTGKPLKEGDTLVQKDLAKSLELIAENGPDAFYKGDIAESIIDTLQKNGGIMTKKDLAAYDVEIRKPLSGDY-RGYQV 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115  279 ISAPPPSAGGVALAQSLQMLE-----QLPWQKAEPVqraHYVLEVLRRAYRDRG-LLGDPDFVANPLPSLLAPDYLKRLA 352
Cdd:TIGR00066 241 YTTPPPSSGGIHLLQALNILEnfdlsQYGDGSAETY---QLLAEAMKLSYADRSrYLGDPEFVDVPLEELLDKRYAKELA 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115  353 AGIDPRRATPSSAL-PEAPAWREGDHTTHFAVIDAQGNAVAATLSVNLPFGAAFTVPGTGVVLNNEMDDFAADTQGansy 431
Cdd:TIGR00066 318 QSIKINKVDPKSTIyPGAYQPNEGSQTTHFSVVDRDGNAVSLTTTINLEFGSGVHAPDTGILLNNEMDDFSLKPGG---- 393
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115  432 glagsqANAVAAGKRPLSSMSPSFL---ESPtdFAAFGTPGGSRIPSMVLISMLQYFD-GRPVGQWVAAPRYHHQYKPDV 507
Cdd:TIGR00066 394 ------ANAVEPNKRPLSSMAPTIVlkdGKP--DLVVGSPGGSRIITTVLQTIVRHIDyGMPLAEAVSEPRIHHQWLPDE 465
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|...
gi 757682115  508 VEYEPRaFSDAEAAELRRRGYQLKRLE-RSYGNQQVLYWDkRSGRVDAASDPR 559
Cdd:TIGR00066 466 LRLEKG-FPDDVLQLLKDMGHKVTLKEvFPMGVVQAIRVD-PEGWLYGVSDPR 516
ggt PRK09615
gamma-glutamyltranspeptidase; Reviewed
37-561 4.08e-88

gamma-glutamyltranspeptidase; Reviewed


Pssm-ID: 181992  Cd Length: 581  Bit Score: 284.11  E-value: 4.08e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115  37 QQAAVATPHPAATVAGLETLANGGNAFDAAAAIAAALAVAEPYGSGLGGGGFFLLRQAGAQPTYrfLDARERAPKAAYAD 116
Cdd:PRK09615  48 KQGMVASVDATATQVGVDILKQGGNAVDAAVAVGYALAVTHPQAGNLGGGGFMLLRTKNGNTTA--IDFREMAPAKATRD 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115 117 MY-RRNGKVDPRLSVDGPLAAAIPGLPAALVELSSRYGRKPLADNLVPAIRLAVDGVSV-DRIYRDRAAMRLEAMRKDPE 194
Cdd:PRK09615 126 MFlDDQGNPDSKKSLTSHLASGTPGTVAGFSLALDKYGTMPLNKVVQPAFKLARDGFIVnDALADDLKTYGSEVLPNHEN 205
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115 195 TARIFLDKGGIPDEWNLLRQPQLARTLERLGRYGRIGFYEGETADKLLTGVRAGGGIWSAADLRDYRVIERRPLEVKLaN 274
Cdd:PRK09615 206 SKAIFWKEGEPLKKGDKLVQANLAKSLEMIAENGPDAFYKGTIADQIAQEMQKNGGLITKEDLAAYKAVERTPISGDY-R 284
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115 275 GRELISAPPPSAGGVALAQSLQMLEQLPWQK-----AEPVQrahYVLEVLRRAYRDRG-LLGDPDFVANPLPSLLAPDYL 348
Cdd:PRK09615 285 GYQVYSMPPPSSGGIHIVQILNILENFDMKKygfgsADAMQ---IMAEAEKYAYADRSeYLGDPDFVKVPWQALTNKAYA 361
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115 349 KRLAAGIDPRRATPSSAL-PEAPAWREGDHTTHFAVIDAQGNAVAATLSVNLPFGAAFTVPGTGVVLNNEMDDFAADTQG 427
Cdd:PRK09615 362 KSIADQIDINKAKPSSEIrPGKLAPYESNQTTHFSVVDKDGNAVAVTYTLNTTFGTGIVAGNSGILLNNQMDDFSAKPGV 441
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115 428 ANSYGLAGSQANAVAAGKRPLSSMSPSFL-ESPTDFAAFGTPGGSRIPSMVLISMLQYFD-GRPVGQWVAAPRYHHQYKP 505
Cdd:PRK09615 442 PNVYGLVGGDANAVGPNKRPLSSMSPTIVvKDGKTWLVTGSPGGSRIITTVLQMVVNSIDyGMNVAEATNAPRFHHQWLP 521
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 757682115 506 DVVEYEpRAFSDAEAAELRRRGYQLKRLERSYGNQQVLYwdKRSGRVDAASDPRGI 561
Cdd:PRK09615 522 DELRVE-KGFSPDTLKLLEAKGQKVALKEAMGSTQSIMV--GPDGELYGASDPRSV 574
PLN02198 PLN02198
glutathione gamma-glutamylcysteinyltransferase
8-565 1.87e-56

glutathione gamma-glutamylcysteinyltransferase


Pssm-ID: 177849  Cd Length: 573  Bit Score: 199.53  E-value: 1.87e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115   8 VRTlvAACGLSLLSLAAHADS-FRGDAHAPQQAAVATPHPAATVAGLETLANGGNAFDAAAAIAAALAVAEPYGSGLGGG 86
Cdd:PLN02198   4 VRT--VTIVLFIIAFLQNAAAqKRQQSIVASHGAVATDDGRCSVIGMNVLREGGNAIDASVAAALCLGVVSPASSGIGGG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115  87 GFFLLRQAGAQPTYrfLDARERAPKAAYADMYRRNgkvdPRLSVDGPLAAAIPGLPAALVELSSRYGRKPLADNLVPAIR 166
Cdd:PLN02198  82 AFTLIKLANGEEIA--YDSRETAPLSATENMYGGN----VELKKKGALSVGVPGEVAGLFTAWKQHGKLPWKRLVRPAEK 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115 167 LAVDGVSVDRIYRDRAAMRLEAMRKDPETARIFLDKGGIPDEWNLLRQPQLARTLERLGRYGRIGFYEGETADKLLTGVR 246
Cdd:PLN02198 156 LAAEGFKISKYLYMQMNATRSDILADKGLSDLFVSNGELKKPGTICHNPKLALTLRLIGEYGPKAFYNGTVGVNLVRDIQ 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115 247 AGGGIWSAADLRDYRVIERRPLEVKLAnGRELISAPPPSAGGVALAQSLQMLEQ--LPWQKAEPVQrAHYVLEVLRRAYR 324
Cdd:PLN02198 236 KSGGIITLKDLQSYRVKVKEPLSADIL-GYRVLGMPPPSSGGAAMMLILNILAQygIPSGVSGPLG-VHRLIEALKHAFA 313
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115 325 DRGLLGDPDF--VANPLPSLLAPDYLKRLAAGI------DPRRAtpssalpeAPAWRE-GDH-TTHFAVIDAQGNAVAAT 394
Cdd:PLN02198 314 VRMNLGDPDFvdVTKVVSDMLSPKFAQDLKSKIndnktfDPKHY--------GGRWNQiDDHgTSHLSIIDSERNAVSMT 385
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115 395 LSVNLPFGAAFTVPGTGVVLNNEMDDFAADTQ-GANSYGLAGSQANAVAAGKRPLSSMSPSF-LESPTDFAAFGTPGGSR 472
Cdd:PLN02198 386 STINGYFGALMLSPSTGIVLNNEMDDFSIPMKsGGNLDVPPPAPANFIRPGKRPLSSMTPTIvLKDGKVKAAVGASGGAN 465
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115 473 IPSMVLISMLQYF--DGRPVGQwVAAPRYHHQYKPDVVEYE--PRAFSD------AEAAELRRRGYQLKRLERSYGNQQV 542
Cdd:PLN02198 466 IIAGTTEVYLNHFflKMDPLSS-VLAPRIYHQLIPNRASYEnwTTVYNDhfeipkATRVVLEKKGHVLSPIAGGTIAQFI 544
                        570       580
                 ....*....|....*....|....*..
gi 757682115 543 LYWDKRS----GRVDAASDPRGIGYSS 565
Cdd:PLN02198 545 VQESGENsggrSELVAVSDPRKGGFPS 571
PLN02180 PLN02180
gamma-glutamyl transpeptidase 4
103-533 2.62e-48

gamma-glutamyl transpeptidase 4


Pssm-ID: 177836  Cd Length: 639  Bit Score: 178.33  E-value: 2.62e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115 103 LDARERAPKAAYADMYrrngKVDPRLSVDGPLAAAIPGLPAALVELSSRYGRKPLADNLVPAIRLAVDGVSVDRIYRDRA 182
Cdd:PLN02180 146 FDMRETAPLAASKDMY----KNDASAKSLGALSMGVPGEIAGLYEAWKRYGRLPWKPLFEPAIELARDGFVVHPYLGKAI 221
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115 183 AMRLEAMRKDPETARIFLDKGGIPDEWNLLRQPQLARTLERLGRYGRIGFYEGETADKLLTGVRAGGGIWSAADLRDYRV 262
Cdd:PLN02180 222 SSHAAMILKDPGLRSVFSRNGQVLKPGETCYNPELAQSLETISEQGPGAFYNGTIGEKLVKDVKKAGGIITMDDLRSYEV 301
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115 263 IERRPLEVKLAnGRELISAPPPSAGGVALAQSLQMLEQLP--WQKAEPVQRAHYVLEVLRRAYRDRGLLGDPDFV--ANP 338
Cdd:PLN02180 302 LVTDAMSVDVM-GYTIHGMPPPSGGTLGFSMVIDILDSYSnlYTASGRELGLHRLIEAMKHMFAARMDLGDPEFVniTNA 380
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115 339 LPSLLAPDYLKRLAAGIDPRRATPSSALPEAPAWREGDHTTHFAVIDAQGNAVAATLSVNLPFGAAFTVPGTGVVLNNEM 418
Cdd:PLN02180 381 MNQMLSKAHAEEIQKRIFDNTTFPPEYYLNRWSQLRDQGTSHFCIVDADRNSVSMTSTVNYGFGAGVLSPSTGIVLNNEM 460
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757682115 419 DDFAADTQGANSYgLAGSQANAVAAGKRPLSSMSPSFLESPTDF-AAFGTPGGSRIPSMVLISMLQYF--DGRPvGQWVA 495
Cdd:PLN02180 461 DDFSTPAEITPDM-LPPAPTNFIEPNKRPLSSMTPLVITKDGEFvAALGGAGGMHIIPAVLQVFLNCFvlNMKP-KEAVE 538
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*.
gi 757682115 496 APRYHHQYKPDVVEYEPR--------AFSDAEAAELRRRGYQLKRL 533
Cdd:PLN02180 539 SARIYHRLIPNVVSYENFtaingdhiGVSEDTKMFLAERGHELKAL 584
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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