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Conserved domains on  [gi|75677565|ref|NP_001028722|]
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volume-regulated anion channel subunit LRRC8B [Mus musculus]

Protein Classification

Pannexin_like and LRR domain-containing protein( domain architecture ID 12117038)

Pannexin_like and LRR domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-334 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


:

Pssm-ID: 463622  Cd Length: 345  Bit Score: 530.65  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565     1 MITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGALQLTQSRVLC-----CLPCKVEFDNQCAVPWDLLKG 75
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVClpcleSPPSTASLDDSYANSLSPTQS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565    76 SENASSNSGLLLPLPLRIQNDLHRQQYSYIDAVCYEKQLHWFAKFFPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVSI 155
Cdd:pfam12534  81 APTVSSPSASMIPEPKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565   156 LHKCFDSPWTTRALSETVAEQSVRPLKLSKSKTLL-----STSGGSADIDASKQSLPYPQPGLESPGIE-SPTSSVLDKK 229
Cdd:pfam12534 161 LGKCFDSPWTTRALSETSGEDSEEKKQRLEGNTVLpkvssSSSLSSSDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDKK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565   230 EGEQAKAIFEKVKRFRLHVEQRDIIYRVYLKQIIVKVILFVLIITYVPYFLSYITLEIDCSIDVQAFTGYKRYQCVYSLA 309
Cdd:pfam12534 241 EGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLA 320

                         330       340
                  ....*....|....*....|....*
gi 75677565   310 EIFKVLASFYVILVMLYGLTSSYSL 334
Cdd:pfam12534 321 FLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
471-802 3.14e-34

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 135.83  E-value: 3.14e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565 471 YHSSLVVDHPALAFLEENLRILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSSLHLEGFQDLKNLRTLYLKSSLS 550
Cdd:COG4886   6 LSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLL 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565 551 RIPQVVTDLLPSLQKLSLDNegsklvvLNNLKKMVNLKSLELLSCDLERIPHSIFSLNNLHELDLKENNLKTVEEiiSFQ 630
Cdd:COG4886  86 LLGLTDLGDLTNLTELDLSG-------NEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE--PLG 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565 631 HLPSLSCLKLWHNNIAYIPAQIGALSNLEQLFLGHNNIESLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLTNLQYFAVT 710
Cdd:COG4886 157 NLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLS 236

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565 711 NNNIEMLPDgLFQCKKLQCLLLGRNSLTDLSPLvGELSNLTHLELTGNYLETLPVELEGCQSLKRSCLIVEDSLLNSLPL 790
Cdd:COG4886 237 NNQLTDLPE-LGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELL 314

                       330
                ....*....|..
gi 75677565 791 PVAERLQTCLDK 802
Cdd:COG4886 315 ILLLLLTTLLLL 326
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-334 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 530.65  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565     1 MITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGALQLTQSRVLC-----CLPCKVEFDNQCAVPWDLLKG 75
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVClpcleSPPSTASLDDSYANSLSPTQS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565    76 SENASSNSGLLLPLPLRIQNDLHRQQYSYIDAVCYEKQLHWFAKFFPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVSI 155
Cdd:pfam12534  81 APTVSSPSASMIPEPKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565   156 LHKCFDSPWTTRALSETVAEQSVRPLKLSKSKTLL-----STSGGSADIDASKQSLPYPQPGLESPGIE-SPTSSVLDKK 229
Cdd:pfam12534 161 LGKCFDSPWTTRALSETSGEDSEEKKQRLEGNTVLpkvssSSSLSSSDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDKK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565   230 EGEQAKAIFEKVKRFRLHVEQRDIIYRVYLKQIIVKVILFVLIITYVPYFLSYITLEIDCSIDVQAFTGYKRYQCVYSLA 309
Cdd:pfam12534 241 EGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLA 320

                         330       340
                  ....*....|....*....|....*
gi 75677565   310 EIFKVLASFYVILVMLYGLTSSYSL 334
Cdd:pfam12534 321 FLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
471-802 3.14e-34

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 135.83  E-value: 3.14e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565 471 YHSSLVVDHPALAFLEENLRILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSSLHLEGFQDLKNLRTLYLKSSLS 550
Cdd:COG4886   6 LSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLL 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565 551 RIPQVVTDLLPSLQKLSLDNegsklvvLNNLKKMVNLKSLELLSCDLERIPHSIFSLNNLHELDLKENNLKTVEEiiSFQ 630
Cdd:COG4886  86 LLGLTDLGDLTNLTELDLSG-------NEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE--PLG 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565 631 HLPSLSCLKLWHNNIAYIPAQIGALSNLEQLFLGHNNIESLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLTNLQYFAVT 710
Cdd:COG4886 157 NLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLS 236

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565 711 NNNIEMLPDgLFQCKKLQCLLLGRNSLTDLSPLvGELSNLTHLELTGNYLETLPVELEGCQSLKRSCLIVEDSLLNSLPL 790
Cdd:COG4886 237 NNQLTDLPE-LGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELL 314

                       330
                ....*....|..
gi 75677565 791 PVAERLQTCLDK 802
Cdd:COG4886 315 ILLLLLTTLLLL 326
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 512-767 9.82e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 81.82  E-value: 9.82e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565  512 LKELYLSGCVLPEQLSSLhlegFQDLKNLRTLYLKSS-LS-RIPQVVTDLLPSLQKLSLDNegsklvvlNNLKKMVNLKS 589
Cdd:PLN00113  71 VVSIDLSGKNISGKISSA----IFRLPYIQTINLSNNqLSgPIPDDIFTTSSSLRYLNLSN--------NNFTGSIPRGS 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565  590 LELL-SCDLE------RIPHSIFSLNNLHELDLKENNLktVEEI-ISFQHLPSLSCLKLWHNN-IAYIPAQIGALSNLEQ 660
Cdd:PLN00113 139 IPNLeTLDLSnnmlsgEIPNDIGSFSSLKVLDLGGNVL--VGKIpNSLTNLTSLEFLTLASNQlVGQIPRELGQMKSLKW 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565  661 LFLGHNNIE-SLPLQLFLCTKLHYLDLSYNHLTF-IPEEIQYLTNLQYFAVTNNNIE-MLPDGLFQCKKLQCLLLGRNSL 737
Cdd:PLN00113 217 IYLGYNNLSgEIPYEIGGLTSLNHLDLVYNNLTGpIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSL 296

                        250       260       270
                 ....*....|....*....|....*....|..
gi 75677565  738 TDLSP-LVGELSNLTHLELTGNYLE-TLPVEL 767
Cdd:PLN00113 297 SGEIPeLVIQLQNLEILHLFSNNFTgKIPVAL 328
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 609-758 2.15e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.12  E-value: 2.15e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565 609 NLHELDLKENNLKTVEeiiSFQHLPSLSCLKLWHNNIAYIPaQIGALSNLEQLFLGHNNIESLPlQLFLCTKLHYLDLSY 688
Cdd:cd21340  25 NLKVLYLYDNKITKIE---NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRISVVE-GLENLTNLEELHIEN 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565 689 NHL------TFIPEEIQYLTN-LQYFAVTNNNIEMLpDGLFQCKKLQCLLLGRN---SLTDLSPLVGELSNLTHLELTGN 758
Cdd:cd21340 100 QRLppgeklTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNqisDLEELLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
702-760 2.28e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 2.28e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 75677565   702 TNLQYFAVTNNNIEMLPDGLFQ-CKKLQCLLLGRNSLTDLSP--LVGeLSNLTHLELTGNYL 760
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSPgaFSG-LPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-334 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 530.65  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565     1 MITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGALQLTQSRVLC-----CLPCKVEFDNQCAVPWDLLKG 75
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVClpcleSPPSTASLDDSYANSLSPTQS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565    76 SENASSNSGLLLPLPLRIQNDLHRQQYSYIDAVCYEKQLHWFAKFFPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVSI 155
Cdd:pfam12534  81 APTVSSPSASMIPEPKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565   156 LHKCFDSPWTTRALSETVAEQSVRPLKLSKSKTLL-----STSGGSADIDASKQSLPYPQPGLESPGIE-SPTSSVLDKK 229
Cdd:pfam12534 161 LGKCFDSPWTTRALSETSGEDSEEKKQRLEGNTVLpkvssSSSLSSSDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDKK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565   230 EGEQAKAIFEKVKRFRLHVEQRDIIYRVYLKQIIVKVILFVLIITYVPYFLSYITLEIDCSIDVQAFTGYKRYQCVYSLA 309
Cdd:pfam12534 241 EGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLA 320

                         330       340
                  ....*....|....*....|....*
gi 75677565   310 EIFKVLASFYVILVMLYGLTSSYSL 334
Cdd:pfam12534 321 FLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
471-802 3.14e-34

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 135.83  E-value: 3.14e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565 471 YHSSLVVDHPALAFLEENLRILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSSLHLEGFQDLKNLRTLYLKSSLS 550
Cdd:COG4886   6 LSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLL 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565 551 RIPQVVTDLLPSLQKLSLDNegsklvvLNNLKKMVNLKSLELLSCDLERIPHSIFSLNNLHELDLKENNLKTVEEiiSFQ 630
Cdd:COG4886  86 LLGLTDLGDLTNLTELDLSG-------NEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE--PLG 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565 631 HLPSLSCLKLWHNNIAYIPAQIGALSNLEQLFLGHNNIESLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLTNLQYFAVT 710
Cdd:COG4886 157 NLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLS 236

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565 711 NNNIEMLPDgLFQCKKLQCLLLGRNSLTDLSPLvGELSNLTHLELTGNYLETLPVELEGCQSLKRSCLIVEDSLLNSLPL 790
Cdd:COG4886 237 NNQLTDLPE-LGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELL 314

                       330
                ....*....|..
gi 75677565 791 PVAERLQTCLDK 802
Cdd:COG4886 315 ILLLLLTTLLLL 326
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
539-789 1.08e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 113.49  E-value: 1.08e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565 539 NLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELLSCDLERIPHSIFSLNNLHELDLKEN 618
Cdd:COG4886   2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565 619 NLKTVEEIISFQHLPSLSCLKLWHNNiayipaQIGALSNLEQLFLGHNNIESLPLQLFLCTKLHYLDLSYNHLTFIPEEI 698
Cdd:COG4886  82 LSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPL 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565 699 QYLTNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGRNSLTDLSPLVGELSNLTHLELTGNYLETLPVELEGCQSLKRscL 778
Cdd:COG4886 156 GNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLET--L 233

                       250
                ....*....|.
gi 75677565 779 IVEDSLLNSLP 789
Cdd:COG4886 234 DLSNNQLTDLP 244
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
368-797 1.48e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 98.08  E-value: 1.48e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565 368 FILHLADQYDPLYSKRFSIFLSEVSENKLKQINLNNEWTVERLKSKLVKNSQDKVELHLFMLNGLPDNVFELTEMEVLSL 447
Cdd:COG4886   3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565 448 ELipEVKLPAAVAQLVNLRELHVYHSslvvdhPALAFLEeNLRILRLKFTEMGKIPRWVFHLKNLKELYLSGCvlpeQLS 527
Cdd:COG4886  83 SL--LLLGLTDLGDLTNLTELDLSGN------EELSNLT-NLESLDLSGNQLTDLPEELANLTNLKELDLSNN----QLT 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565 528 SLHlEGFQDLKNLRTLYLKS-SLSRIPQVVTDLlPSLQKLSLDNegSKLVVL-NNLKKMVNLKSLELLSCDLERIPHSIF 605
Cdd:COG4886 150 DLP-EPLGNLTNLKSLDLSNnQLTDLPEELGNL-TNLKELDLSN--NQITDLpEPLGNLTNLEELDLSGNQLTDLPEPLA 225

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565 606 SLNNLHELDLKENNLKTVEEIisfQHLPSLSCLKLWHNNIAYIPAqIGALSNLEQLFLGHNNIESLPLQ-LFLCTKLHYL 684
Cdd:COG4886 226 NLTNLETLDLSNNQLTDLPEL---GNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTDLKLKeLELLLGLNSL 301

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565 685 DLSYNHLTFIPEEIQYLTNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGRNSLTDLSPLVGELSNLTHLELTGNYLETLP 764
Cdd:COG4886 302 LLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLT 381

                       410       420       430
                ....*....|....*....|....*....|...
gi 75677565 765 VELEGCQSLKRSCLIVEDSLLNSLPLPVAERLQ 797
Cdd:COG4886 382 LALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
338-743 4.88e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.46  E-value: 4.88e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565 338 LRSSLKQYSFEALREKSNYSDIPDVKNDFAFILHLADQYDPLYSKRFSIFLSEVSENKLKQINLNNEWTVERLKSKLVKN 417
Cdd:COG4886  12 LLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTD 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565 418 SQDKVELHLFMLNGlPDNVFELTEMEVLSLELIPEVKLPAAVAQLVNLRELHVYHSSLVVDHPALAFLEeNLRILRLKFT 497
Cdd:COG4886  92 LGDLTNLTELDLSG-NEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLT-NLKSLDLSNN 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565 498 EMGKIPRWVFHLKNLKELYLSGCvlpeQLSSLHLEgFQDLKNLRTLYL-KSSLSRIPQVVTDlLPSLQKLSLDNegSKLV 576
Cdd:COG4886 170 QLTDLPEELGNLTNLKELDLSNN----QITDLPEP-LGNLTNLEELDLsGNQLTDLPEPLAN-LTNLETLDLSN--NQLT 241

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565 577 VLNNLKKMVNLKSLELLSCDLERIPHSiFSLNNLHELDLKENNLKT--VEEIISFQHLPSLSCLKLWHNNIAYIPAQIGA 654
Cdd:COG4886 242 DLPELGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQLTDlkLKELELLLGLNSLLLLLLLLNLLELLILLLLL 320

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565 655 LSNLEQLFLGHNN---IESLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLTNLQYFAVTNNNIEMLPDGLFQCKKLQCLL 731
Cdd:COG4886 321 TTLLLLLLLLKGLlvtLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGV 400

                       410
                ....*....|..
gi 75677565 732 LGRNSLTDLSPL 743
Cdd:COG4886 401 LLLTLALLDAVN 412
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 512-767 9.82e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 81.82  E-value: 9.82e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565  512 LKELYLSGCVLPEQLSSLhlegFQDLKNLRTLYLKSS-LS-RIPQVVTDLLPSLQKLSLDNegsklvvlNNLKKMVNLKS 589
Cdd:PLN00113  71 VVSIDLSGKNISGKISSA----IFRLPYIQTINLSNNqLSgPIPDDIFTTSSSLRYLNLSN--------NNFTGSIPRGS 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565  590 LELL-SCDLE------RIPHSIFSLNNLHELDLKENNLktVEEI-ISFQHLPSLSCLKLWHNN-IAYIPAQIGALSNLEQ 660
Cdd:PLN00113 139 IPNLeTLDLSnnmlsgEIPNDIGSFSSLKVLDLGGNVL--VGKIpNSLTNLTSLEFLTLASNQlVGQIPRELGQMKSLKW 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565  661 LFLGHNNIE-SLPLQLFLCTKLHYLDLSYNHLTF-IPEEIQYLTNLQYFAVTNNNIE-MLPDGLFQCKKLQCLLLGRNSL 737
Cdd:PLN00113 217 IYLGYNNLSgEIPYEIGGLTSLNHLDLVYNNLTGpIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSL 296

                        250       260       270
                 ....*....|....*....|....*....|..
gi 75677565  738 TDLSP-LVGELSNLTHLELTGNYLE-TLPVEL 767
Cdd:PLN00113 297 SGEIPeLVIQLQNLEILHLFSNNFTgKIPVAL 328
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
485-795 7.40e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 72.42  E-value: 7.40e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565  485 LEENLRILRLKFTEMGKIPRWVfhlknlkelylsgcvlPEQLSSLHLEGfQDLK--------NLRTLYLKSS-LSRIPQV 555
Cdd:PRK15370 176 LKNNKTELRLKILGLTTIPACI----------------PEQITTLILDN-NELKslpenlqgNIKTLYANSNqLTSIPAT 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565  556 VTDllpSLQKLSLDnegsklvvLNNLKKMVnlkslellscdlERIPHSifslnnLHELDLKENNLKTVEEiisfqHLPS- 634
Cdd:PRK15370 239 LPD---TIQEMELS--------INRITELP------------ERLPSA------LQSLDLFHNKISCLPE-----NLPEe 284

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565  635 LSCLKLWHNNIAYIPAQIGalSNLEQLFLGHNNIESLPLQLFLctKLHYLDLSYNHLTFIPEEIQylTNLQYFAVTNNNI 714
Cdd:PRK15370 285 LRYLSVYDNSIRTLPAHLP--SGITHLNVQSNSLTALPETLPP--GLKTLEAGENALTSLPASLP--PELQVLDVSKNQI 358

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565  715 EMLPDGLfqCKKLQCLLLGRNSLTDLSPLVGelSNLTHLELTGNYLETLPVEL-----EGCQSLKrscLIVEDSllnslp 789
Cdd:PRK15370 359 TVLPETL--PPTITTLDVSRNALTNLPENLP--AALQIMQASRNNLVRLPESLphfrgEGPQPTR---IIVEYN------ 425


                 ....*.
gi 75677565  790 lPVAER 795
Cdd:PRK15370 426 -PFSER 430
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 455-773 1.01e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 72.19  E-value: 1.01e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565  455 LPAAVAQLVNLRELHVYHSSLVVDHPALAFLEENLRILRL---KFTemGKIPRWVFHLKNLKELYLSGCVLPEQLSSLHL 531
Cdd:PLN00113 228 IPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLyqnKLS--GPIPPSIFSLQKLISLDLSDNSLSGEIPELVI 305

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565  532 EgfqdLKNLRTLYLKSS--LSRIPQVVTDLlPSLQKLSL-DNEGS-----------KLVVL----NNLKKMV-------- 585
Cdd:PLN00113 306 Q----LQNLEILHLFSNnfTGKIPVALTSL-PRLQVLQLwSNKFSgeipknlgkhnNLTVLdlstNNLTGEIpeglcssg 380

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565  586 NLKSLELLSCDLE-RIPHSIFSLNNLHELDLKENNLkTVEEIISFQHLPSLSCLKLWHNNI-AYIPAQIGALSNLEQLFL 663
Cdd:PLN00113 381 NLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSF-SGELPSEFTKLPLVYFLDISNNNLqGRINSRKWDMPSLQMLSL 459

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565  664 GHNNIESLPLQLFLCTKLHYLDLSYNHLT-FIPEEIQYLTNLQYFAVTNNNIE-MLPDGLFQCKKLQCLLLGRNSLTDLS 741
Cdd:PLN00113 460 ARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSGQI 539

                        330       340       350
                 ....*....|....*....|....*....|....
gi 75677565  742 PL-VGELSNLTHLELTGNYLE-TLPVELEGCQSL 773
Cdd:PLN00113 540 PAsFSEMPVLSQLDLSQNQLSgEIPKNLGNVESL 573
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 500-775 1.58e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 71.42  E-value: 1.58e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565  500 GKIPRWVFHLKNLKELYLSGCVLpeqlsslhlegfqdlknlrtlylkssLSRIPQVVTDlLPSLQKLSLDNEGSKLVVLN 579
Cdd:PLN00113 154 GEIPNDIGSFSSLKVLDLGGNVL--------------------------VGKIPNSLTN-LTSLEFLTLASNQLVGQIPR 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565  580 NLKKMVNLKSLELLSCDLE-RIPHSIFSLNNLHELDLKENNLktveeiisfqhlpslsclklwhnnIAYIPAQIGALSNL 658
Cdd:PLN00113 207 ELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVYNNL------------------------TGPIPSSLGNLKNL 262

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565  659 EQLFLGHNNIE-SLPLQLFLCTKLHYLDLSYNHLTF-IPEEIQYLTNLQYFAVTNNNIE-MLPDGLFQCKKLQCLLLGRN 735
Cdd:PLN00113 263 QYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSGeIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWSN 342

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 75677565  736 SLT----------------DLSP--LVGEL-------SNLTHLELTGNYLET-LPVELEGCQSLKR 775
Cdd:PLN00113 343 KFSgeipknlgkhnnltvlDLSTnnLTGEIpeglcssGNLFKLILFSNSLEGeIPKSLGACRSLRR 408
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 609-758 2.15e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.12  E-value: 2.15e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565 609 NLHELDLKENNLKTVEeiiSFQHLPSLSCLKLWHNNIAYIPaQIGALSNLEQLFLGHNNIESLPlQLFLCTKLHYLDLSY 688
Cdd:cd21340  25 NLKVLYLYDNKITKIE---NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRISVVE-GLENLTNLEELHIEN 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565 689 NHL------TFIPEEIQYLTN-LQYFAVTNNNIEMLpDGLFQCKKLQCLLLGRN---SLTDLSPLVGELSNLTHLELTGN 758
Cdd:cd21340 100 QRLppgeklTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNqisDLEELLDLLSSWPSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 488-773 2.12e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 67.57  E-value: 2.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565  488 NLRILRLKFTE-MGKIPRWVFHLKNLKELYLSGCVLPEQLSSlhleGFQDLKNLRTLYLK-SSLS-RIPQVVTDLLpSLQ 564
Cdd:PLN00113 165 SLKVLDLGGNVlVGKIPNSLTNLTSLEFLTLASNQLVGQIPR----ELGQMKSLKWIYLGyNNLSgEIPYEIGGLT-SLN 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565  565 KLSLdnegsklvVLNNLKKMV-----NLKSLELLSCDLER----IPHSIFSLNNLHELDLKENNL--KTVEEIISFQH-- 631
Cdd:PLN00113 240 HLDL--------VYNNLTGPIpsslgNLKNLQYLFLYQNKlsgpIPPSIFSLQKLISLDLSDNSLsgEIPELVIQLQNle 311

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565  632 -------------------LPSLSCLKLWHNNIA-YIPAQIGALSNLEQLFLGHNNI-----ESL--------------- 671
Cdd:PLN00113 312 ilhlfsnnftgkipvaltsLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLtgeipEGLcssgnlfklilfsns 391

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565  672 -----PLQLFLCTKLHYLDLSYNHLTF-IPEEIQYLTNLQYFAVTNNNI---------EM----------------LPDg 720
Cdd:PLN00113 392 legeiPKSLGACRSLRRVRLQDNSFSGeLPSEFTKLPLVYFLDISNNNLqgrinsrkwDMpslqmlslarnkffggLPD- 470

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 75677565  721 LFQCKKLQCLLLGRNSLTDLSPL-VGELSNLTHLELTGNYLE-TLPVELEGCQSL 773
Cdd:PLN00113 471 SFGSKRLENLDLSRNQFSGAVPRkLGSLSELMQLKLSENKLSgEIPDELSSCKKL 525
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 607-775 2.17e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.42  E-value: 2.17e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565 607 LNNLHELDLKENNLKTVEEIISFqhlPSLSCLKLWHNNIAYIPaQIGALSNLEQLFLGHNNIESLPlQLFLCTKLHYLDL 686
Cdd:cd21340   1 LKRITHLYLNDKNITKIDNLSLC---KNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYL 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565 687 SYNHLTFIpEEIQYLTNLQYFAVTNNNiemLPDG---LFQC-------KKLQCLLLGRNSLTDLSPLVGeLSNLTHLELT 756
Cdd:cd21340  76 GGNRISVV-EGLENLTNLEELHIENQR---LPPGeklTFDPrslaalsNSLRVLNISGNNIDSLEPLAP-LRNLEQLDAS 150

                       170       180
                ....*....|....*....|..
gi 75677565 757 GNYL---ETLPVELEGCQSLKR 775
Cdd:cd21340 151 NNQIsdlEELLDLLSSWPSLRE 172
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
578-797 6.93e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 62.79  E-value: 6.93e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565  578 LNNLKKMVNLKSLELLScdlerIPHSIfsLNNLHELDLKENNLKTVEEIISfqhlPSLSCLKLWHNNIAYIPAQIGalSN 657
Cdd:PRK15370 176 LKNNKTELRLKILGLTT-----IPACI--PEQITTLILDNNELKSLPENLQ----GNIKTLYANSNQLTSIPATLP--DT 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565  658 LEQLFLGHNNIESLPLQLflCTKLHYLDLSYNHLTFIPEEIQylTNLQYFAVTNNNIEMLPDGLfqckklqclllgrnsl 737
Cdd:PRK15370 243 IQEMELSINRITELPERL--PSALQSLDLFHNKISCLPENLP--EELRYLSVYDNSIRTLPAHL---------------- 302

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 75677565  738 tdlsPlvgelSNLTHLELTGNYL----ETLPVELEgcqslkrsCLIVEDSLLNSLPLPVAERLQ 797
Cdd:PRK15370 303 ----P-----SGITHLNVQSNSLtalpETLPPGLK--------TLEAGENALTSLPASLPPELQ 349
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 428-692 8.17e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.01  E-value: 8.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565  428 MLNG-LPDNVFELTEMevLSLEL--------IPEVklpaaVAQLVNLRELHVYHSSLVVDHP-ALAFLEEnLRILRL--- 494
Cdd:PLN00113 271 KLSGpIPPSIFSLQKL--ISLDLsdnslsgeIPEL-----VIQLQNLEILHLFSNNFTGKIPvALTSLPR-LQVLQLwsn 342

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565  495 KFTemGKIPRWVFHLKNLKELYLSGCVLPEQLSslhlEGFQDLKNLRTLYLKS-SL-SRIPQVVTDLlPSLQKLSLDNEG 572
Cdd:PLN00113 343 KFS--GEIPKNLGKHNNLTVLDLSTNNLTGEIP----EGLCSSGNLFKLILFSnSLeGEIPKSLGAC-RSLRRVRLQDNS 415

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565  573 SKLVVLNNLKKMVNLKSLELLSCDLE-RIPHSIFSLNNLHELDLKENNLktveeiisFQHLP------SLSCLKLWHNNI 645
Cdd:PLN00113 416 FSGELPSEFTKLPLVYFLDISNNNLQgRINSRKWDMPSLQMLSLARNKF--------FGGLPdsfgskRLENLDLSRNQF 487

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 75677565  646 A-YIPAQIGALSNLEQLFLGHNNIES-LPLQLFLCTKLHYLDLSYNHLT 692
Cdd:PLN00113 488 SgAVPRKLGSLSELMQLKLSENKLSGeIPDELSSCKKLVSLDLSHNQLS 536
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 531-760 2.85e-07

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 53.64  E-value: 2.85e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565 531 LEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSL--QKLSLDNEGS-KLVVLNNLKKMVNLKSLELLSCDLERIPHSIFSL 607
Cdd:COG5238 128 EDSLILYLALPRRINLIQVLKDPLGGNAVHLLGlaARLGLLAAISmAKALQNNSVETVYLGCNQIGDEGIEELAEALTQN 207

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565 608 NNLHELDLKENNL--KTVEEIIS-FQHLPSLSCLKLWHNNI--AYIPAQIGAL---SNLEQLFLGHNNI-----ESLPLQ 674
Cdd:COG5238 208 TTVTTLWLKRNPIgdEGAEILAEaLKGNKSLTTLDLSNNQIgdEGVIALAEALknnTTVETLYLSGNQIgaegaIALAKA 287

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565 675 LFLCTKLHYLDLSYNHLTFipeeiqyltnlqyfavtnNNIEMLPDGLFQCKKLQCLLLGRNSLTD-----LSPLVGELSN 749
Cdd:COG5238 288 LQGNTTLTSLDLSVNRIGD------------------EGAIALAEGLQGNKTLHTLNLAYNGIGAqgaiaLAKALQENTT 349

                       250
                ....*....|.
gi 75677565 750 LTHLELTGNYL 760
Cdd:COG5238 350 LHSLDLSDNQI 360
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 410-790 5.01e-07

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 53.73  E-value: 5.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565   410 LKSKLVKNSQDKVELHLFMLNGLPDNVFELtEMEVLSLElipevKLPAAVAQLVNLRELHVYHSSLVVDHPALAfLEENL 489
Cdd:PLN03210  587 LPPKLRLLRWDKYPLRCMPSNFRPENLVKL-QMQGSKLE-----KLWDGVHSLTGLRNIDLRGSKNLKEIPDLS-MATNL 659

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565   490 RILRL-KFTEMGKIPRWVFHLKNLKELYLSGC----VLP-----EQLSSLHLEGFQDLKNLRTLYLKSSLSRIPQVVTDL 559
Cdd:PLN03210  660 ETLKLsDCSSLVELPSSIQYLNKLEDLDMSRCenleILPtginlKSLYRLNLSGCSRLKSFPDISTNISWLDLDETAIEE 739

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565   560 LPSlqKLSLDNegSKLVVLNNLKKMVNLKSLELLSCDLERIPHSifslnnLHELDLkENNLKTVEEIISFQHLPSLSCLK 639
Cdd:PLN03210  740 FPS--NLRLEN--LDELILCEMKSEKLWERVQPLTPLMTMLSPS------LTRLFL-SDIPSLVELPSSIQNLHKLEHLE 808

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565   640 LWH-NNIAYIPAQIGaLSNLEQLFLGH-NNIESLPlqlFLCTKLHYLDLSYNHLTFIPEEIQYLTNLQYFAVTN-NNIEM 716
Cdd:PLN03210  809 IENcINLETLPTGIN-LESLESLDLSGcSRLRTFP---DISTNISDLNLSRTGIEEVPWWIEKFSNLSFLDMNGcNNLQR 884

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565   717 LPDGLFQCKKLQ------CLLLGRNSLTDLSPLVGELSNLTHLELTgnylETLPVELEGCQSLKRSCLIVEDSLLNSLPL 790
Cdd:PLN03210  885 VSLNISKLKHLEtvdfsdCGALTEASWNGSPSEVAMATDNIHSKLP----STVCINFINCFNLDQEALLQQQSIFKQLIL 960
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 508-618 7.42e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.94  E-value: 7.42e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565 508 HLKNLKELYLSGcvlpEQLSslHLEGFQDLKNLRTLYLKS-------SLSRIPQVVTDLLPSLQKLSLdnEGSKLVVLNN 580
Cdd:cd21340  66 NLVNLKKLYLGG----NRIS--VVEGLENLTNLEELHIENqrlppgeKLTFDPRSLAALSNSLRVLNI--SGNNIDSLEP 137

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 75677565 581 LKKMVNLKSLELLSCDLERIP---HSIFSLNNLHELDLKEN 618
Cdd:cd21340 138 LAPLRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGN 178
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 597-777 6.49e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.89  E-value: 6.49e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565 597 LERIPHSIFSLNNLHELDLKENNL--KTVEEIISFQHLPSLSCLKLWHNNIAYIPAQI--GAL----SNLEQLFLGHNNI 668
Cdd:cd00116  70 LQSLLQGLTKGCGLQELDLSDNALgpDGCGVLESLLRSSSLQELKLNNNGLGDRGLRLlaKGLkdlpPALEKLVLGRNRL 149

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565 669 -----ESLPLQLFLCTKLHYLDLSYNHLTfiPEEIQYLT------------NLQYFAVTNNNIEMLPDGLFQCKKLQCLL 731
Cdd:cd00116 150 egascEALAKALRANRDLKELNLANNGIG--DAGIRALAeglkancnlevlDLNNNGLTDEGASALAETLASLKSLEVLN 227

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 75677565 732 LGRNSLTD------LSPLVGELSNLTHLELTGNYLetlpvELEGCQSLKRSC 777
Cdd:cd00116 228 LGDNNLTDagaaalASALLSPNISLLTLSLSCNDI-----TDDGAKDLAEVL 274
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 508-692 2.15e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.32  E-value: 2.15e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565 508 HLKNLKELYLSGcvlpEQLSSLhlEGFQDLKNLRTLYLksSLSRIpQVVTDL--LPSLQKLSLDNegsklvvlnnlkkmV 585
Cdd:cd21340  44 FLTNLTHLYLQN----NQIEKI--ENLENLVNLKKLYL--GGNRI-SVVEGLenLTNLEELHIEN--------------Q 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565 586 NLKSLELLSCDleriPHSIFSL-NNLHELDLKENNLKTVEEiisfqhlpsLSCLKlwhnniayipaqigalsNLEQLFLG 664
Cdd:cd21340 101 RLPPGEKLTFD----PRSLAALsNSLRVLNISGNNIDSLEP---------LAPLR-----------------NLEQLDAS 150

                       170       180       190
                ....*....|....*....|....*....|.
gi 75677565 665 HNNIESL-PLQLFL--CTKLHYLDLSYNHLT 692
Cdd:cd21340 151 NNQISDLeELLDLLssWPSLRELDLTGNPVC 181
LRR_8 pfam13855
Leucine rich repeat;
702-760 2.28e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 2.28e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 75677565   702 TNLQYFAVTNNNIEMLPDGLFQ-CKKLQCLLLGRNSLTDLSP--LVGeLSNLTHLELTGNYL 760
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSPgaFSG-LPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
586-645 4.02e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 4.02e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 75677565   586 NLKSLELLSCDLERIPHSIFS-LNNLHELDLKENNLKTVEEiISFQHLPSLSCLKLWHNNI 645
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
633-691 4.48e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 4.48e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 75677565   633 PSLSCLKLWHNNIAYI-PAQIGALSNLEQLFLGHNNIESLPLQLFLC-TKLHYLDLSYNHL 691
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
633-773 7.27e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 43.23  E-value: 7.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565  633 PSLSCLKLWHNNIAYIPAqigALSNLEQLFLGHNNIESLPLqlfLCTKLHYLDLSYNHLTFIPEEIQYLTNLQYFAVTNN 712
Cdd:PRK15387 302 PGLQELSVSDNQLASLPA---LPSELCKLWAYNNQLTSLPT---LPSGLQELSVSDNQLASLPTLPSELYKLWAYNNRLT 375

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 75677565  713 NIEMLPDGLFQckklqcLLLGRNSLTDLSPLVGELSNLThleLTGNYLETLPVELEGCQSL 773
Cdd:PRK15387 376 SLPALPSGLKE------LIVSGNRLTSLPVLPSELKELM---VSGNRLTSLPMLPSGLLSL 427
LRR_8 pfam13855
Leucine rich repeat;
679-737 1.17e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 1.17e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 75677565   679 TKLHYLDLSYNHLTFIPEEI-QYLTNLQYFAVTNNNIEMLPDGLFQC-KKLQCLLLGRNSL 737
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
511-570 1.62e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 1.62e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 75677565   511 NLKELYLSGCvlpeQLSSLHLEGFQDLKNLRTLYLKS-SLSRIPQVVTDLLPSLQKLSLDN 570
Cdd:pfam13855   2 NLRSLDLSNN----RLTSLDDGAFKGLSNLKVLDLSNnLLTTLSPGAFSGLPSLRYLDLSG 58
PLN03150 PLN03150
hypothetical protein; Provisional
 693-769 2.45e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 41.34  E-value: 2.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565  693 FIPEEIQYLTNLQYFAVTNNNIE-MLPDGLFQCKKLQCLLLGRNSLTDLSP-LVGELSNLTHLELTGNYLE-TLPVELEG 769
Cdd:PLN03150 433 FIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNGSIPeSLGQLTSLRILNLNGNSLSgRVPAALGG 512
LRR_8 pfam13855
Leucine rich repeat;
488-545 3.94e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 3.94e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 75677565   488 NLRILRLKFTEMGKI-PRWVFHLKNLKELYLSGcvlpEQLSSLHLEGFQDLKNLRTLYL 545
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSN----NLLTTLSPGAFSGLPSLRYLDL 56
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 529-774 7.42e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 39.86  E-value: 7.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565   529 LHLEGFQDLKNLrtLYLKSSLSR----------IPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKmvNLKSLELLSCDLE 598
Cdd:PLN03210  549 IHENAFKGMRNL--LFLKFYTKKwdqkkevrwhLPEGFDYLPPKLRLLRWDKYPLRCMPSNFRPE--NLVKLQMQGSKLE 624

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565   599 RIPHSIFSLNNLHELDL-KENNLKtveEIISFQHLPSLSCLKLWH-NNIAYIPAQIGALSNLEQLFL-GHNNIESLP--- 672
Cdd:PLN03210  625 KLWDGVHSLTGLRNIDLrGSKNLK---EIPDLSMATNLETLKLSDcSSLVELPSSIQYLNKLEDLDMsRCENLEILPtgi 701

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677565   673 -------LQLFLCTKLH----------YLDLSYNHLTFIPEEIQyLTNLQYFAVTNNNIEMLPDGLFQCKKLQCLL---L 732
Cdd:PLN03210  702 nlkslyrLNLSGCSRLKsfpdistnisWLDLDETAIEEFPSNLR-LENLDELILCEMKSEKLWERVQPLTPLMTMLspsL 780

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 75677565   733 GRNSLTDLSPLV---GELSNLTHLELTG----NYLETLP----------VELEGCQSLK 774
Cdd:PLN03210  781 TRLFLSDIPSLVelpSSIQNLHKLEHLEiencINLETLPtginleslesLDLSGCSRLR 839
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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