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Conserved domains on  [gi|755545657|ref|XP_011242878|]
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centrosomal protein of 72 kDa isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 42-144 1.50e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 70.20  E-value: 1.50e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755545657  42 ITHLGNSLMHLtalkslDLSRNSLVSLEGIQYLVSLESLNLYYNCISSLAEVFR-LHTLLELQDVDFRLNPVVKNeSDYR 120
Cdd:cd21340  115 LAALSNSLRVL------NISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDlLSSWPSLRELDLTGNPVCKK-PKYR 187

                         90       100
                 ....*....|....*....|....
gi 755545657 121 LFVVHMLPKLRQLDDRPVRESERK 144
Cdd:cd21340  188 DKIILASKSLEVLDGKEITDTERQ 211
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
476-631 1.65e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


:

Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 44.51  E-value: 1.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755545657 476 LSLENKTLQSRLAEQQQQYTATVTKMTAELNNTKRELDTLRQHLDKSLEENSHLKSLLYNVKKEVKTADTS-TALTLQIT 554
Cdd:COG4372   18 LRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQlQAAQAELA 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755545657 555 GLQASMKQLSGEVVELKQHVEH----YDKIQELTQMLQESHSSL---VSTNEHLLQELSRTRAQHRAEVEQMRWSFQEFK 627
Cdd:COG4372   98 QAQEELESLQEEAEELQEELEElqkeRQDLEQQRKQLEAQIAELqseIAEREEELKELEEQLESLQEELAALEQELQALS 177


                 ....
gi 755545657 628 KTTA 631
Cdd:COG4372  178 EAEA 181
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 42-144 1.50e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 70.20  E-value: 1.50e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755545657  42 ITHLGNSLMHLtalkslDLSRNSLVSLEGIQYLVSLESLNLYYNCISSLAEVFR-LHTLLELQDVDFRLNPVVKNeSDYR 120
Cdd:cd21340  115 LAALSNSLRVL------NISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDlLSSWPSLRELDLTGNPVCKK-PKYR 187

                         90       100
                 ....*....|....*....|....
gi 755545657 121 LFVVHMLPKLRQLDDRPVRESERK 144
Cdd:cd21340  188 DKIILASKSLEVLDGKEITDTERQ 211
LRR_9 pfam14580
Leucine-rich repeat;
51-150 2.81e-11

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 62.47  E-value: 2.81e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755545657   51 HLTALKSLDLSRNSLVSL-EGI-QYLVSLESLNLYYNCISSLAEVFRLHTLLELQDVDFRLNPVVkNESDYRLFVVHMLP 128
Cdd:pfam14580  62 LLRRLKTLLLNNNRICRIgEGLgEALPNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVT-NKPHYRLYVIYKVP 140

                          90       100
                  ....*....|....*....|..
gi 755545657  129 KLRQLDDRPVRESERKASQLHF 150
Cdd:pfam14580 141 QLRLLDFRKVKQKERQAAEKMF 162
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
26-112 1.14e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.72  E-value: 1.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755545657  26 LAELRSLSIPGTyqeKITHLGNSLMHLTALKSLDLSRNSLVSLEGIQYLVSLESLNLYYNCISSLAEVFRLHtllELQDV 105
Cdd:COG4886  204 LTNLEELDLSGN---QLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLT---NLKTL 277


                 ....*..
gi 755545657 106 DFRLNPV 112
Cdd:COG4886  278 DLSNNQL 284
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
476-631 1.65e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 44.51  E-value: 1.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755545657 476 LSLENKTLQSRLAEQQQQYTATVTKMTAELNNTKRELDTLRQHLDKSLEENSHLKSLLYNVKKEVKTADTS-TALTLQIT 554
Cdd:COG4372   18 LRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQlQAAQAELA 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755545657 555 GLQASMKQLSGEVVELKQHVEH----YDKIQELTQMLQESHSSL---VSTNEHLLQELSRTRAQHRAEVEQMRWSFQEFK 627
Cdd:COG4372   98 QAQEELESLQEEAEELQEELEElqkeRQDLEQQRKQLEAQIAELqseIAEREEELKELEEQLESLQEELAALEQELQALS 177


                 ....
gi 755545657 628 KTTA 631
Cdd:COG4372  178 EAEA 181
LRRcap smart00446
occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich ...
 117-134 1.39e-03

occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich repeats in "sds22-like" and "typical" LRR-containing proteins.


Pssm-ID: 197729  Cd Length: 19  Bit Score: 36.13  E-value: 1.39e-03
                           10
                   ....*....|....*...
gi 755545657   117 SDYRLFVVHMLPKLRQLD 134
Cdd:smart00446   2 AHYREKVIELLPQLRKLD 19
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 479-589 1.43e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 41.93  E-value: 1.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755545657  479 ENKTLQSR---LAEQQQQYTATVTKMTAELNNTKRELDTLRQHLDKSLEENSHLKSLLYNVKKEVKTADTstaltlQITG 555
Cdd:TIGR04523 212 KNKSLESQiseLKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNK------KIKE 285

                          90       100       110
                  ....*....|....*....|....*....|....
gi 755545657  556 LQASMKQLSGEVVELKQhvehyDKIQELTQMLQE 589
Cdd:TIGR04523 286 LEKQLNQLKSEISDLNN-----QKEQDWNKELKS 314
ClyA_Cry6Aa-like cd22656
Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes ...
 443-560 4.87e-03

Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes pesticidal Cry6Aa toxin from Bacillus thuringiensis, one of the many parasporal crystal (Cry) toxins produced during the sporulation phase of growth. Many of these proteins are toxic to numerous insect species and have been effectively used as proteinaceous insecticides to directly kill insect pests; some have been used to control insect growth on transgenic agricultural plants. Cry6Aa exists as a protoxin, which is activated by cleavage using trypsin. Structure studies for Cry6Aa support a mechanism of action by pore formation, similar to cytolysin A (ClyA)-type alpha pore-forming toxins (alpha-PFTs) such as HblB, and bioassay and mutation studies show that Cry6Aa is an active pore-forming toxin. Cry6Aa shows atypical features compared to other members of alpha-PFTs, including internal repeat sequences and small loop regions within major alpha helices.


Pssm-ID: 439154 [Multi-domain]  Cd Length: 309  Bit Score: 39.66  E-value: 4.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755545657 443 EAFLAQAKHVLSSLQEF-TATRD------------SSALEKEGIGYLSLENKTLQSRLAEQQQQYTAtvtKMTAELNNTK 509
Cdd:cd22656  131 KKYQDKAAKVVDKLTDFeNQTEKdqtaletlekalKDLLTDEGGAIARKEIKDLQKELEKLNEEYAA---KLKAKIDELK 207

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 755545657 510 RELDTLRQHLdksleenshlksllynvKKEVKTADTSTALTLQITGLQASM 560
Cdd:cd22656  208 ALIADDEAKL-----------------AAALRLIADLTAADTDLDNLLALI 241
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 42-144 1.50e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 70.20  E-value: 1.50e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755545657  42 ITHLGNSLMHLtalkslDLSRNSLVSLEGIQYLVSLESLNLYYNCISSLAEVFR-LHTLLELQDVDFRLNPVVKNeSDYR 120
Cdd:cd21340  115 LAALSNSLRVL------NISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDlLSSWPSLRELDLTGNPVCKK-PKYR 187

                         90       100
                 ....*....|....*....|....
gi 755545657 121 LFVVHMLPKLRQLDDRPVRESERK 144
Cdd:cd21340  188 DKIILASKSLEVLDGKEITDTERQ 211
LRR_9 pfam14580
Leucine-rich repeat;
51-150 2.81e-11

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 62.47  E-value: 2.81e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755545657   51 HLTALKSLDLSRNSLVSL-EGI-QYLVSLESLNLYYNCISSLAEVFRLHTLLELQDVDFRLNPVVkNESDYRLFVVHMLP 128
Cdd:pfam14580  62 LLRRLKTLLLNNNRICRIgEGLgEALPNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVT-NKPHYRLYVIYKVP 140

                          90       100
                  ....*....|....*....|..
gi 755545657  129 KLRQLDDRPVRESERKASQLHF 150
Cdd:pfam14580 141 QLRLLDFRKVKQKERQAAEKMF 162
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
26-112 1.14e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.72  E-value: 1.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755545657  26 LAELRSLSIPGTyqeKITHLGNSLMHLTALKSLDLSRNSLVSLEGIQYLVSLESLNLYYNCISSLAEVFRLHtllELQDV 105
Cdd:COG4886  204 LTNLEELDLSGN---QLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLT---NLKTL 277


                 ....*..
gi 755545657 106 DFRLNPV 112
Cdd:COG4886  278 DLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
26-102 3.91e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.18  E-value: 3.91e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755545657  26 LAELRSLSIPGTyqeKITHLGNSLMHLTALKSLDLSRNSLVSL-EGIQYLVSLESLNLYYNCISSLAEVF-RLHTLLEL 102
Cdd:COG4886  135 LTNLKELDLSNN---QLTDLPEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLPEPLgNLTNLEEL 210
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
26-102 2.14e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.87  E-value: 2.14e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755545657  26 LAELRSLSIPGTyqeKITHLGNSLMHLTALKSLDLSRNSLVSL-EGIQYLVSLESLNLYYNCISSLAEVFRLHTLLEL 102
Cdd:COG4886  181 LTNLKELDLSNN---QITDLPEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEEL 255
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
26-102 6.30e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 55.32  E-value: 6.30e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755545657  26 LAELRSLSIPGTyqeKITHLGNSLMHLTALKSLDLSRNSLVSL-EGIQYLVSLESLNLYYNCISSL-AEVFRLHTLLEL 102
Cdd:COG4886  112 LTNLESLDLSGN---QLTDLPEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKEL 187
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
26-90 1.37e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.92  E-value: 1.37e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755545657  26 LAELRSLSIPGTyqeKITHLGnSLMHLTALKSLDLSRNSLVSLEGIQYLVSLESLNLYYNCISSL 90
Cdd:COG4886  227 LTNLETLDLSNN---QLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDL 287
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
476-631 1.65e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 44.51  E-value: 1.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755545657 476 LSLENKTLQSRLAEQQQQYTATVTKMTAELNNTKRELDTLRQHLDKSLEENSHLKSLLYNVKKEVKTADTS-TALTLQIT 554
Cdd:COG4372   18 LRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQlQAAQAELA 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755545657 555 GLQASMKQLSGEVVELKQHVEH----YDKIQELTQMLQESHSSL---VSTNEHLLQELSRTRAQHRAEVEQMRWSFQEFK 627
Cdd:COG4372   98 QAQEELESLQEEAEELQEELEElqkeRQDLEQQRKQLEAQIAELqseIAEREEELKELEEQLESLQEELAALEQELQALS 177


                 ....
gi 755545657 628 KTTA 631
Cdd:COG4372  178 EAEA 181
LRR_8 pfam13855
Leucine rich repeat;
28-85 6.09e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 6.09e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755545657   28 ELRSLSIPGTYqekITHLGN-SLMHLTALKSLDLSRNSLVSLEG--IQYLVSLESLNLYYN 85
Cdd:pfam13855   2 NLRSLDLSNNR---LTSLDDgAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 40-103 1.16e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.92  E-value: 1.16e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755545657  40 EKITHLGNslmhLTALKSLDLSRNSLVSLEGIQYLVSLESLNLYYNCISSLAEVFRLHTLLELQ 103
Cdd:cd21340   37 TKIENLEF----LTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELH 96
LRRcap smart00446
occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich ...
 117-134 1.39e-03

occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich repeats in "sds22-like" and "typical" LRR-containing proteins.


Pssm-ID: 197729  Cd Length: 19  Bit Score: 36.13  E-value: 1.39e-03
                           10
                   ....*....|....*...
gi 755545657   117 SDYRLFVVHMLPKLRQLD 134
Cdd:smart00446   2 AHYREKVIELLPQLRKLD 19
LRR_8 pfam13855
Leucine rich repeat;
55-90 1.40e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 1.40e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 755545657   55 LKSLDLSRNSLVSLEG--IQYLVSLESLNLYYNCISSL 90
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTL 40
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 479-589 1.43e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 41.93  E-value: 1.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755545657  479 ENKTLQSR---LAEQQQQYTATVTKMTAELNNTKRELDTLRQHLDKSLEENSHLKSLLYNVKKEVKTADTstaltlQITG 555
Cdd:TIGR04523 212 KNKSLESQiseLKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNK------KIKE 285

                          90       100       110
                  ....*....|....*....|....*....|....
gi 755545657  556 LQASMKQLSGEVVELKQhvehyDKIQELTQMLQE 589
Cdd:TIGR04523 286 LEKQLNQLKSEISDLNN-----QKEQDWNKELKS 314
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 53-85 1.78e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 1.78e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 755545657   53 TALKSLDLSRNSLVSLEGIQYLVSLESLNLYYN 85
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGN 33
ClyA_Cry6Aa-like cd22656
Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes ...
 443-560 4.87e-03

Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes pesticidal Cry6Aa toxin from Bacillus thuringiensis, one of the many parasporal crystal (Cry) toxins produced during the sporulation phase of growth. Many of these proteins are toxic to numerous insect species and have been effectively used as proteinaceous insecticides to directly kill insect pests; some have been used to control insect growth on transgenic agricultural plants. Cry6Aa exists as a protoxin, which is activated by cleavage using trypsin. Structure studies for Cry6Aa support a mechanism of action by pore formation, similar to cytolysin A (ClyA)-type alpha pore-forming toxins (alpha-PFTs) such as HblB, and bioassay and mutation studies show that Cry6Aa is an active pore-forming toxin. Cry6Aa shows atypical features compared to other members of alpha-PFTs, including internal repeat sequences and small loop regions within major alpha helices.


Pssm-ID: 439154 [Multi-domain]  Cd Length: 309  Bit Score: 39.66  E-value: 4.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755545657 443 EAFLAQAKHVLSSLQEF-TATRD------------SSALEKEGIGYLSLENKTLQSRLAEQQQQYTAtvtKMTAELNNTK 509
Cdd:cd22656  131 KKYQDKAAKVVDKLTDFeNQTEKdqtaletlekalKDLLTDEGGAIARKEIKDLQKELEKLNEEYAA---KLKAKIDELK 207

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 755545657 510 RELDTLRQHLdksleenshlksllynvKKEVKTADTSTALTLQITGLQASM 560
Cdd:cd22656  208 ALIADDEAKL-----------------AAALRLIADLTAADTDLDNLLALI 241
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 475-620 5.11e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.92  E-value: 5.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755545657 475 YLSLENKTLQSRLAEQQQQYTATVTKM---TAELNNTKRELDTLRQHLDKSLEENSHLKSLLYNVKKEVKTADTS-TALT 550
Cdd:COG1196  229 LLLLKLRELEAELEELEAELEELEAELeelEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDiARLE 308

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755545657 551 LQITGLQASMKQLSGEVVELKQHVE-HYDKIQELTQMLQESHSSLVSTNEHLLQELSRTRAQHRAEVEQMR 620
Cdd:COG1196  309 ERRRELEERLEELEEELAELEEELEeLEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEE 379
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
469-619 7.02e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 39.61  E-value: 7.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755545657 469 EKEGIGYLSLENKTLQSRLAEQQQQYTATvtkmTAELNNTKRELDTLRQHLDKSLEENShlksllynvkkEVKTADTSTA 548
Cdd:COG3206  203 QKNGLVDLSEEAKLLLQQLSELESQLAEA----RAELAEAEARLAALRAQLGSGPDALP-----------ELLQSPVIQQ 267

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755545657 549 LTLQITGLQASMKQLSG-------EVVELKQHVEHYDK-IQELTQMLQESHSSLVSTNEHLLQELSRTRAQHRAEVEQM 619
Cdd:COG3206  268 LRAQLAELEAELAELSArytpnhpDVIALRAQIAALRAqLQQEAQRILASLEAELEALQAREASLQAQLAQLEARLAEL 346
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
479-604 9.41e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 38.73  E-value: 9.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755545657 479 ENKTLQSRLAEQQQQYTAT---VTKMTAELNNTKRELDTLRQHLDKSLEENSHLKSLLYNVKKEVKTADTSTALTL-QIT 554
Cdd:COG4372   74 ELEQLEEELEELNEQLQAAqaeLAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREeELK 153

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 755545657 555 GLQASMKQLSGEVVELKQHVEHYDK---IQELTQMLQESHSSLVSTNEHLLQE 604
Cdd:COG4372  154 ELEEQLESLQEELAALEQELQALSEaeaEQALDELLKEANRNAEKEEELAEAE 206
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 481-620 9.43e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 38.37  E-value: 9.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755545657 481 KTLQSRLAEQQQQYTA---TVTKMTAELNNTKRELDTLRQHLDKSLEENSHLKSLLynvkKEVKTADTSTALTLQITGLQ 557
Cdd:COG1579   27 KELPAELAELEDELAAleaRLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQL----GNVRNNKEYEALQKEIESLK 102

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755545657 558 ASMKQLSGEVVELKQHVEHYDKIQELtqmLQESHSSLVSTNEHLLQELSRTRAQHRAEVEQMR 620
Cdd:COG1579  103 RRISDLEDEILELMERIEELEEELAE---LEAELAELEAELEEKKAELDEELAELEAELEELE 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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