DNA primase large subunit isoform X2 [Mus musculus]
DNA primase large subunit( domain architecture ID 10164070)
DNA primase large subunit is the regulatory subunit of the DNA primase complex and a component of the DNA polymerase alpha complex (called the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis
List of domain hits
Name | Accession | Description | Interval | E-value | ||||
PriL_PriS_Eukaryotic | cd07322 | Eukaryotic core primase: Large subunit, PriL; Primases synthesize the RNA primers required for ... |
16-236 | 1.13e-132 | ||||
Eukaryotic core primase: Large subunit, PriL; Primases synthesize the RNA primers required for DNA replication. Primases are grouped into two classes, bacteria/bacteriophage and archaeal/eukaryotic. The proteins in the two classes differ in structure and the replication apparatus components. Archaeal/eukaryotic core primase is a heterodimeric enzyme consisting of a small catalytic subunit (PriS) and a large subunit (PriL). In eukaryotic organisms, a heterotetrameric enzyme formed by DNA polymerase alpha, the B subunit and two primase subunits has primase activity. Although the catalytic activity resides within PriS, the PriL subunit is essential for primase function as disruption of the PriL gene in yeast is lethal. PriL is composed of two structural domains. Several functions have been proposed for PriL such as stabilization of the PriS, involvement in synthesis initiation, improvement of primase processivity, determination of product size and transfer of the products to DNA polymerase alpha. : Pssm-ID: 143474 [Multi-domain] Cd Length: 390 Bit Score: 381.22 E-value: 1.13e-132
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Name | Accession | Description | Interval | E-value | ||||
PriL_PriS_Eukaryotic | cd07322 | Eukaryotic core primase: Large subunit, PriL; Primases synthesize the RNA primers required for ... |
16-236 | 1.13e-132 | ||||
Eukaryotic core primase: Large subunit, PriL; Primases synthesize the RNA primers required for DNA replication. Primases are grouped into two classes, bacteria/bacteriophage and archaeal/eukaryotic. The proteins in the two classes differ in structure and the replication apparatus components. Archaeal/eukaryotic core primase is a heterodimeric enzyme consisting of a small catalytic subunit (PriS) and a large subunit (PriL). In eukaryotic organisms, a heterotetrameric enzyme formed by DNA polymerase alpha, the B subunit and two primase subunits has primase activity. Although the catalytic activity resides within PriS, the PriL subunit is essential for primase function as disruption of the PriL gene in yeast is lethal. PriL is composed of two structural domains. Several functions have been proposed for PriL such as stabilization of the PriS, involvement in synthesis initiation, improvement of primase processivity, determination of product size and transfer of the products to DNA polymerase alpha. Pssm-ID: 143474 [Multi-domain] Cd Length: 390 Bit Score: 381.22 E-value: 1.13e-132
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DNA_primase_lrg | pfam04104 | Eukaryotic and archaeal DNA primase, large subunit; DNA primase is the polymerase that ... |
14-233 | 1.65e-70 | ||||
Eukaryotic and archaeal DNA primase, large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. DNA primase is a heterodimer of two subunits, the small subunit Pri1 (48 kDa in yeast), and the large subunit Pri2 (58 kDa in the yeast S. cerevisiae). The large subunit of DNA primase forms interactions with the small subunit and the structure implicates that it is not directly involved in catalysis, but plays roles in correctly positioning the primase/DNA complex, and in the transfer of RNA to DNA polymerase. Pssm-ID: 397980 Cd Length: 222 Bit Score: 217.31 E-value: 1.65e-70
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PRI2 | COG2219 | Eukaryotic-type DNA primase, large subunit [Replication, recombination and repair]; |
55-154 | 1.59e-09 | ||||
Eukaryotic-type DNA primase, large subunit [Replication, recombination and repair]; Pssm-ID: 441821 [Multi-domain] Cd Length: 346 Bit Score: 58.01 E-value: 1.59e-09
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PRK02249 | PRK02249 | DNA primase regulatory subunit PriL; |
19-154 | 9.82e-08 | ||||
DNA primase regulatory subunit PriL; Pssm-ID: 179392 [Multi-domain] Cd Length: 343 Bit Score: 52.28 E-value: 9.82e-08
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Name | Accession | Description | Interval | E-value | ||||
PriL_PriS_Eukaryotic | cd07322 | Eukaryotic core primase: Large subunit, PriL; Primases synthesize the RNA primers required for ... |
16-236 | 1.13e-132 | ||||
Eukaryotic core primase: Large subunit, PriL; Primases synthesize the RNA primers required for DNA replication. Primases are grouped into two classes, bacteria/bacteriophage and archaeal/eukaryotic. The proteins in the two classes differ in structure and the replication apparatus components. Archaeal/eukaryotic core primase is a heterodimeric enzyme consisting of a small catalytic subunit (PriS) and a large subunit (PriL). In eukaryotic organisms, a heterotetrameric enzyme formed by DNA polymerase alpha, the B subunit and two primase subunits has primase activity. Although the catalytic activity resides within PriS, the PriL subunit is essential for primase function as disruption of the PriL gene in yeast is lethal. PriL is composed of two structural domains. Several functions have been proposed for PriL such as stabilization of the PriS, involvement in synthesis initiation, improvement of primase processivity, determination of product size and transfer of the products to DNA polymerase alpha. Pssm-ID: 143474 [Multi-domain] Cd Length: 390 Bit Score: 381.22 E-value: 1.13e-132
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DNA_primase_lrg | pfam04104 | Eukaryotic and archaeal DNA primase, large subunit; DNA primase is the polymerase that ... |
14-233 | 1.65e-70 | ||||
Eukaryotic and archaeal DNA primase, large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. DNA primase is a heterodimer of two subunits, the small subunit Pri1 (48 kDa in yeast), and the large subunit Pri2 (58 kDa in the yeast S. cerevisiae). The large subunit of DNA primase forms interactions with the small subunit and the structure implicates that it is not directly involved in catalysis, but plays roles in correctly positioning the primase/DNA complex, and in the transfer of RNA to DNA polymerase. Pssm-ID: 397980 Cd Length: 222 Bit Score: 217.31 E-value: 1.65e-70
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PRI2 | COG2219 | Eukaryotic-type DNA primase, large subunit [Replication, recombination and repair]; |
55-154 | 1.59e-09 | ||||
Eukaryotic-type DNA primase, large subunit [Replication, recombination and repair]; Pssm-ID: 441821 [Multi-domain] Cd Length: 346 Bit Score: 58.01 E-value: 1.59e-09
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PRK02249 | PRK02249 | DNA primase regulatory subunit PriL; |
19-154 | 9.82e-08 | ||||
DNA primase regulatory subunit PriL; Pssm-ID: 179392 [Multi-domain] Cd Length: 343 Bit Score: 52.28 E-value: 9.82e-08
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Blast search parameters | ||||
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