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Conserved domains on  [gi|755144531|ref|WP_042494539|]
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threonine/serine exporter family protein [Weissella sagaensis]

Protein Classification

threonine/serine exporter family protein( domain architecture ID 10581889)

threonine/serine exporter family protein similar to ThrE, a membrane protein involved in the export of threonine and serine

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ThrE_2 pfam12821
Threonine/Serine exporter, ThrE; ThrE_2 is a family of membrane proteins involved in the ...
 7-133 4.45e-32

Threonine/Serine exporter, ThrE; ThrE_2 is a family of membrane proteins involved in the export of threonine and serine. L-threonine, L-serine are both substrates for the exporter. The exporter exhibits nine-ten predicted transmembrane-spanning helices with long charged C and N termini and an amphipathic helix present within the N terminus. L-Threonine can be made by the amino acid-producing bacterium Corynebacterium glutamicum, but the potential for amino acid formation can be considerably improved by reducing its intracellular degradation into glycine and increasing its export by this exporter. Members of the family are found in Bacteria, Archaea, and the fungal kingdoms, and the family can exist either as a single long polypeptide chain or as two short polypeptides. All family members show an extended hydrophilic N-terminal domain with weak sequence similarity to portions of hydrolases (proteases, peptidases, and glycosidases); this suggests that since this region is cytoplasmic to the membrane it may be generating the transport substrate, so may imply that threonine may not be the primary substrate and the ThrE has a subsidiary function.


:

Pssm-ID: 432807  Cd Length: 129  Bit Score: 110.30  E-value: 4.45e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755144531    7 FIFSFLSTVGFGIITNVPRRVLLYAGMTGAFGWTVYLLAESVTSNLILPNFLAALTIGLLGNVAAIRVKAPVNMIYVPSL 86
Cdd:pfam12821   2 LIFAFIATLGFGILFNVPKRALFYAGIGGAVGWLVYLLLMHFGSSIALASFLAALAIGLLSEIFARRLKAPVTVFLVPGI 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 755144531   87 VSLVPGVIIYTSLKEFALGNYMHAGQNLVKTLVIALAIDIGFAIAES 133
Cdd:pfam12821  82 IPLVPGGGAYNTMYYLVQGNYALAVSYGLETLFIAGAIALGLVLVSL 128
 
Name Accession Description Interval E-value
ThrE_2 pfam12821
Threonine/Serine exporter, ThrE; ThrE_2 is a family of membrane proteins involved in the ...
 7-133 4.45e-32

Threonine/Serine exporter, ThrE; ThrE_2 is a family of membrane proteins involved in the export of threonine and serine. L-threonine, L-serine are both substrates for the exporter. The exporter exhibits nine-ten predicted transmembrane-spanning helices with long charged C and N termini and an amphipathic helix present within the N terminus. L-Threonine can be made by the amino acid-producing bacterium Corynebacterium glutamicum, but the potential for amino acid formation can be considerably improved by reducing its intracellular degradation into glycine and increasing its export by this exporter. Members of the family are found in Bacteria, Archaea, and the fungal kingdoms, and the family can exist either as a single long polypeptide chain or as two short polypeptides. All family members show an extended hydrophilic N-terminal domain with weak sequence similarity to portions of hydrolases (proteases, peptidases, and glycosidases); this suggests that since this region is cytoplasmic to the membrane it may be generating the transport substrate, so may imply that threonine may not be the primary substrate and the ThrE has a subsidiary function.


Pssm-ID: 432807  Cd Length: 129  Bit Score: 110.30  E-value: 4.45e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755144531    7 FIFSFLSTVGFGIITNVPRRVLLYAGMTGAFGWTVYLLAESVTSNLILPNFLAALTIGLLGNVAAIRVKAPVNMIYVPSL 86
Cdd:pfam12821   2 LIFAFIATLGFGILFNVPKRALFYAGIGGAVGWLVYLLLMHFGSSIALASFLAALAIGLLSEIFARRLKAPVTVFLVPGI 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 755144531   87 VSLVPGVIIYTSLKEFALGNYMHAGQNLVKTLVIALAIDIGFAIAES 133
Cdd:pfam12821  82 IPLVPGGGAYNTMYYLVQGNYALAVSYGLETLFIAGAIALGLVLVSL 128
YjjB COG3610
Uncharacterized membrane protein YjjB, DUF3815 family [Function unknown];
1-136 5.30e-32

Uncharacterized membrane protein YjjB, DUF3815 family [Function unknown];


Pssm-ID: 442828  Cd Length: 150  Bit Score: 111.06  E-value: 5.30e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755144531   1 MTILTGFIFSFLSTVGFGIITNVPRRVLLYAGMTGAFGWTVYLLAESVTSNLILPNFLAALTIGLLGNVAAIRVKAPVNM 80
Cdd:COG3610    4 LPLLLQLLAAFVAAVGFAVLFNAPRRALLWAGLGGALGWLVYLLLLDLGLGPVLATFVAALVVGLLAELLARRLKAPATV 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 755144531  81 IYVPSLVSLVPGVIIYTSLKEFALGNYMHAGQNLVKTLVIALAIDIGFAIAESLFK 136
Cdd:COG3610   84 FTVPGIIPLVPGSGAYRAMYALVEGDYLAALSNGLEALLIAGALAAGLLLGSLLAR 139
PRK09917 PRK09917
threonine/serine exporter;
2-99 4.40e-04

threonine/serine exporter;


Pssm-ID: 182143  Cd Length: 157  Bit Score: 38.21  E-value: 4.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755144531   2 TILTGFIFSFLSTVGFGIITNVPRRVLLYAGMTGAFGWTVYLLAESVTSNLILPNFLAALTIGLLGNVAAIRVKAPVNMI 81
Cdd:PRK09917   9 ALAQDMILAAIPAVGFAMVFNVPVRALRWCALLGAIGHGSRMLMMTSGLNIEWSTFMASMLVGTIGIQWSRWYLAHPKVF 88

                         90
                 ....*....|....*...
gi 755144531  82 YVPSLVSLVPGVIIYTSL 99
Cdd:PRK09917  89 TVAAVIPMFPGISAYTAM 106
 
Name Accession Description Interval E-value
ThrE_2 pfam12821
Threonine/Serine exporter, ThrE; ThrE_2 is a family of membrane proteins involved in the ...
 7-133 4.45e-32

Threonine/Serine exporter, ThrE; ThrE_2 is a family of membrane proteins involved in the export of threonine and serine. L-threonine, L-serine are both substrates for the exporter. The exporter exhibits nine-ten predicted transmembrane-spanning helices with long charged C and N termini and an amphipathic helix present within the N terminus. L-Threonine can be made by the amino acid-producing bacterium Corynebacterium glutamicum, but the potential for amino acid formation can be considerably improved by reducing its intracellular degradation into glycine and increasing its export by this exporter. Members of the family are found in Bacteria, Archaea, and the fungal kingdoms, and the family can exist either as a single long polypeptide chain or as two short polypeptides. All family members show an extended hydrophilic N-terminal domain with weak sequence similarity to portions of hydrolases (proteases, peptidases, and glycosidases); this suggests that since this region is cytoplasmic to the membrane it may be generating the transport substrate, so may imply that threonine may not be the primary substrate and the ThrE has a subsidiary function.


Pssm-ID: 432807  Cd Length: 129  Bit Score: 110.30  E-value: 4.45e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755144531    7 FIFSFLSTVGFGIITNVPRRVLLYAGMTGAFGWTVYLLAESVTSNLILPNFLAALTIGLLGNVAAIRVKAPVNMIYVPSL 86
Cdd:pfam12821   2 LIFAFIATLGFGILFNVPKRALFYAGIGGAVGWLVYLLLMHFGSSIALASFLAALAIGLLSEIFARRLKAPVTVFLVPGI 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 755144531   87 VSLVPGVIIYTSLKEFALGNYMHAGQNLVKTLVIALAIDIGFAIAES 133
Cdd:pfam12821  82 IPLVPGGGAYNTMYYLVQGNYALAVSYGLETLFIAGAIALGLVLVSL 128
YjjB COG3610
Uncharacterized membrane protein YjjB, DUF3815 family [Function unknown];
1-136 5.30e-32

Uncharacterized membrane protein YjjB, DUF3815 family [Function unknown];


Pssm-ID: 442828  Cd Length: 150  Bit Score: 111.06  E-value: 5.30e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755144531   1 MTILTGFIFSFLSTVGFGIITNVPRRVLLYAGMTGAFGWTVYLLAESVTSNLILPNFLAALTIGLLGNVAAIRVKAPVNM 80
Cdd:COG3610    4 LPLLLQLLAAFVAAVGFAVLFNAPRRALLWAGLGGALGWLVYLLLLDLGLGPVLATFVAALVVGLLAELLARRLKAPATV 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 755144531  81 IYVPSLVSLVPGVIIYTSLKEFALGNYMHAGQNLVKTLVIALAIDIGFAIAESLFK 136
Cdd:COG3610   84 FTVPGIIPLVPGSGAYRAMYALVEGDYLAALSNGLEALLIAGALAAGLLLGSLLAR 139
ThrE pfam06738
Putative threonine/serine exporter; ThrE is a family of bacterial and Archaeal proteins that ...
 8-135 2.38e-07

Putative threonine/serine exporter; ThrE is a family of bacterial and Archaeal proteins that catalyze the export of L-threonine from the cell. UniProtKB:Q79VD1 has been characterized as being necessary for this export. The domain exhibits 10 putative TMs and catalyzes the proton-motive-force-dependent efflux of threonine and serine.


Pssm-ID: 461997  Cd Length: 241  Bit Score: 47.90  E-value: 2.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755144531    8 IFSFLSTVGFGIITNVPRRVLLYAGMTGAFGWTVYLLAESVTSNLILPNFLAALTIGLLGNVAA-IRVKAPVNMIYVPSL 86
Cdd:pfam06738 113 LAAGLASAAFALLFGGDWIDFLVAFLAGGLGGLLRLVLNRRGLNSFFFEAVAAFVASLLALLAVsLGLGINPDAIIIGSI 192

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 755144531   87 VSLVPGVIIYTSLKEFALGNYMHAGQNLVKTLVIALAIDIGFAIAESLF 135
Cdd:pfam06738 193 MLLVPGLPLTNAVRDLIAGDLVSGLARLVEAILIALAIAFGIALALALL 241
PRK09917 PRK09917
threonine/serine exporter;
2-99 4.40e-04

threonine/serine exporter;


Pssm-ID: 182143  Cd Length: 157  Bit Score: 38.21  E-value: 4.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755144531   2 TILTGFIFSFLSTVGFGIITNVPRRVLLYAGMTGAFGWTVYLLAESVTSNLILPNFLAALTIGLLGNVAAIRVKAPVNMI 81
Cdd:PRK09917   9 ALAQDMILAAIPAVGFAMVFNVPVRALRWCALLGAIGHGSRMLMMTSGLNIEWSTFMASMLVGTIGIQWSRWYLAHPKVF 88

                         90
                 ....*....|....*...
gi 755144531  82 YVPSLVSLVPGVIIYTSL 99
Cdd:PRK09917  89 TVAAVIPMFPGISAYTAM 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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