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Conserved domains on  [gi|752687074|ref|WP_041334992|]
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MULTISPECIES: MFS transporter [Bacillus]

Protein Classification

MFS transporter( domain architecture ID 11457990)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0005886|GO:0016020|GO:0022857|GO:0055085
PubMed:  26098515|9529885|26758938|23403214
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
52-341 2.37e-14

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


:

Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 73.85  E-value: 2.37e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074  52 LAIYNLSIVTMQPItfylAGRLAKKIDRVFILRFGVIFLAAFYLSVLLAGETAAsrLVLIGAVLGVGYGFYWLAFNVLTF 131
Cdd:COG2814   51 VTAYLLGAALGAPL----AGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWL--LLAARFLQGLGAGALFPAALALIA 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074 132 EITEPDTRDFFNGFMGILSSSAGMIGPIVAGFVISRLenntGYTVIFSLSLSLFALAVVMS-FFLKRRESKGRFMLSKVF 210
Cdd:COG2814  125 DLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF----GWRWVFLVNAVLALLALLLLlRLLPESRPAARARLRGSL 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074 211 GERHSNMNWRRITNAHFFQGLREGIFVFLISVFVFIETN-SELALGTFGLVNSAVSFFAYYFASRLIKKKARKKSILLGG 289
Cdd:COG2814  201 RELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGlSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGL 280

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 752687074 290 LILYGALFLILFHMSFSTLLTYGVFIAIGYPLLLVPYVSLTYDVIGHARHAR 341
Cdd:COG2814  281 LLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGR 332
 
Name Accession Description Interval E-value
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
52-341 2.37e-14

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 73.85  E-value: 2.37e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074  52 LAIYNLSIVTMQPItfylAGRLAKKIDRVFILRFGVIFLAAFYLSVLLAGETAAsrLVLIGAVLGVGYGFYWLAFNVLTF 131
Cdd:COG2814   51 VTAYLLGAALGAPL----AGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWL--LLAARFLQGLGAGALFPAALALIA 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074 132 EITEPDTRDFFNGFMGILSSSAGMIGPIVAGFVISRLenntGYTVIFSLSLSLFALAVVMS-FFLKRRESKGRFMLSKVF 210
Cdd:COG2814  125 DLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF----GWRWVFLVNAVLALLALLLLlRLLPESRPAARARLRGSL 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074 211 GERHSNMNWRRITNAHFFQGLREGIFVFLISVFVFIETN-SELALGTFGLVNSAVSFFAYYFASRLIKKKARKKSILLGG 289
Cdd:COG2814  201 RELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGlSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGL 280

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 752687074 290 LILYGALFLILFHMSFSTLLTYGVFIAIGYPLLLVPYVSLTYDVIGHARHAR 341
Cdd:COG2814  281 LLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGR 332
MFS_1 pfam07690
Major Facilitator Superfamily;
17-341 2.46e-13

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 70.91  E-value: 2.46e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074   17 LLFLLTIGGLYSLGIALSNTFVNVYLWKQSGKFIDLAIYNLSIVTMQPitfyLAGRLAKKIDRVFILRFGVIFLAAFYLS 96
Cdd:pfam07690   3 LAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQP----LAGRLSDRFGRRRVLLIGLLLFALGLLL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074   97 VLLAGETAAsrLVLIGAVLGVGYGFYWLAFNVLTFEITEPDTRDFFNGFMGILSSSAGMIGPIVAGFVISRLenntGYTV 176
Cdd:pfam07690  79 LLFASSLWL--LLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF----GWRA 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074  177 IFSLSLSLFALAVVMSFFLKRR-------ESKGRFMLSKVFGERHSNMNWRRITNAHFFQGLREGIFVFLISVFVFIETN 249
Cdd:pfam07690 153 AFLILAILSLLAAVLLLLPRPPpeskrpkPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGL 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074  250 SELALGTFGLVNSAVSFFAYYFASRLIKKKARKKSILLG-GLILYGALFLILFHMSFSTLLTYGVFIAIG--YPLLLVPY 326
Cdd:pfam07690 233 SALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLAlLLLILAALGLLLLSLTLSSLWLLLALLLLGfgFGLVFPAL 312

                         330
                  ....*....|....*
gi 752687074  327 VSLTYDVIGHARHAR 341
Cdd:pfam07690 313 NALVSDLAPKEERGT 327
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 65-341 4.30e-12

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 67.23  E-value: 4.30e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074  65 ITFYLAGRLAKKIDRVFILRFGVIFLAAFYLSVLLAGETAAsrLVLIGAVLGVGYGFYWLAFNVLTFEITEPDTRDFFNG 144
Cdd:cd17489   46 LARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVAL--LLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIG 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074 145 FMGILSSSAGMIGPIVAGFVIsrleNNTGYTVIFSLSLSLFALAVVMSFFLKRR--ESKGRFMLSKVFGERHSNMNWRRI 222
Cdd:cd17489  124 YYGLATTLAMALGPALGLFLY----QHLGFAVLFIVAAVLALLALLLVFLVKDPppVAAEEAEAGTRAFRRLVEKKVLPP 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074 223 TNAHFFQGLREGIFVFLISVFVfIETNSELAlGTFGLVNSAVSFFAYYFASRLIKKKARKKSILLGGLILYGALFLILFH 302
Cdd:cd17489  200 ALILFLASIAYGAISTFLPLYA-AERGISNA-GLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFA 277

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 752687074 303 MSFSTLLTYGVFIAIGYPLLLVPYVSLTYDVIGHARHAR 341
Cdd:cd17489  278 GSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGA 316
 
Name Accession Description Interval E-value
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
52-341 2.37e-14

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 73.85  E-value: 2.37e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074  52 LAIYNLSIVTMQPItfylAGRLAKKIDRVFILRFGVIFLAAFYLSVLLAGETAAsrLVLIGAVLGVGYGFYWLAFNVLTF 131
Cdd:COG2814   51 VTAYLLGAALGAPL----AGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWL--LLAARFLQGLGAGALFPAALALIA 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074 132 EITEPDTRDFFNGFMGILSSSAGMIGPIVAGFVISRLenntGYTVIFSLSLSLFALAVVMS-FFLKRRESKGRFMLSKVF 210
Cdd:COG2814  125 DLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF----GWRWVFLVNAVLALLALLLLlRLLPESRPAARARLRGSL 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074 211 GERHSNMNWRRITNAHFFQGLREGIFVFLISVFVFIETN-SELALGTFGLVNSAVSFFAYYFASRLIKKKARKKSILLGG 289
Cdd:COG2814  201 RELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGlSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGL 280

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 752687074 290 LILYGALFLILFHMSFSTLLTYGVFIAIGYPLLLVPYVSLTYDVIGHARHAR 341
Cdd:COG2814  281 LLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGR 332
MFS_1 pfam07690
Major Facilitator Superfamily;
17-341 2.46e-13

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 70.91  E-value: 2.46e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074   17 LLFLLTIGGLYSLGIALSNTFVNVYLWKQSGKFIDLAIYNLSIVTMQPitfyLAGRLAKKIDRVFILRFGVIFLAAFYLS 96
Cdd:pfam07690   3 LAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQP----LAGRLSDRFGRRRVLLIGLLLFALGLLL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074   97 VLLAGETAAsrLVLIGAVLGVGYGFYWLAFNVLTFEITEPDTRDFFNGFMGILSSSAGMIGPIVAGFVISRLenntGYTV 176
Cdd:pfam07690  79 LLFASSLWL--LLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF----GWRA 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074  177 IFSLSLSLFALAVVMSFFLKRR-------ESKGRFMLSKVFGERHSNMNWRRITNAHFFQGLREGIFVFLISVFVFIETN 249
Cdd:pfam07690 153 AFLILAILSLLAAVLLLLPRPPpeskrpkPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGL 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074  250 SELALGTFGLVNSAVSFFAYYFASRLIKKKARKKSILLG-GLILYGALFLILFHMSFSTLLTYGVFIAIG--YPLLLVPY 326
Cdd:pfam07690 233 SALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLAlLLLILAALGLLLLSLTLSSLWLLLALLLLGfgFGLVFPAL 312

                         330
                  ....*....|....*
gi 752687074  327 VSLTYDVIGHARHAR 341
Cdd:pfam07690 313 NALVSDLAPKEERGT 327
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 65-341 4.30e-12

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 67.23  E-value: 4.30e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074  65 ITFYLAGRLAKKIDRVFILRFGVIFLAAFYLSVLLAGETAAsrLVLIGAVLGVGYGFYWLAFNVLTFEITEPDTRDFFNG 144
Cdd:cd17489   46 LARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVAL--LLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIG 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074 145 FMGILSSSAGMIGPIVAGFVIsrleNNTGYTVIFSLSLSLFALAVVMSFFLKRR--ESKGRFMLSKVFGERHSNMNWRRI 222
Cdd:cd17489  124 YYGLATTLAMALGPALGLFLY----QHLGFAVLFIVAAVLALLALLLVFLVKDPppVAAEEAEAGTRAFRRLVEKKVLPP 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074 223 TNAHFFQGLREGIFVFLISVFVfIETNSELAlGTFGLVNSAVSFFAYYFASRLIKKKARKKSILLGGLILYGALFLILFH 302
Cdd:cd17489  200 ALILFLASIAYGAISTFLPLYA-AERGISNA-GLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFA 277

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 752687074 303 MSFSTLLTYGVFIAIGYPLLLVPYVSLTYDVIGHARHAR 341
Cdd:cd17489  278 GSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGA 316
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 52-329 3.01e-11

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 64.52  E-value: 3.01e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074  52 LAIYNLSIVTMQPItfylAGRLAKKIDRVFILRFGVIFLAAFYLSVLLAGETAAsrLVLIGAVLGVGYGFYWLAFNVLTF 131
Cdd:cd17325   37 VAAYALAQLLFSPP----AGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQ--LLLARFLQGLASAAVWPAAMALIA 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074 132 EITEPDTRDFFNGFMGILSSSAGMIGPIVAGFVISRLenntGYTVIFSLSLSLFALAVVMSFFLKRRES----KGRFMLS 207
Cdd:cd17325  111 DIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL----GYRAPFLVCAALALLALVLALLLLPEPRpppnKRAVSAA 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074 208 KVFGERHSNMNWRRI---TNAHFFQGLREGIFVFLISVFVFIETN-SELALGTFGLVNSAVSFFAYYFASRLIKKKARKK 283
Cdd:cd17325  187 RLRSGLRLLLRDRRLlalFLAIFVLAFAFGALEPFLPLYAAELGGlSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKP 266

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 752687074 284 SILLGGLILYGALFLILFHMSFSTLLTYGVFIAIGYPLLLVPYVSL 329
Cdd:cd17325  267 LILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLAL 312
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
25-372 7.79e-11

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 63.77  E-value: 7.79e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074  25 GLYSLGIALSNTFVNVYLWK--QSGKFIDLA-------IYNLSIVTMQPITFYLAGRLAKKIDR--VFILRFGVIFLAAF 93
Cdd:COG2211   16 GLGDLGLNLAFGLLSAYLLYfyTDVLGLSAAlvglillVARLWDAITDPLIGALSDRTRTRWGRrrPWILIGAIPLALSF 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074  94 YLSVLLAGETAASRLVLIGA---VLGVGYGFYWLAFNVLTFEIT-EPDTRDFFNGFMGILSSSAGMIGPIVAGFVISRLE 169
Cdd:COG2211   96 VLLFTAPDLSPTGKLIYALVtylLLGLAYTLVNIPYSALGAELTpDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFG 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074 170 NNT--GYTVIFSLSLSLFALAVVMSFFL---KRRESKGRFMLSKVFGERHSNMNWRRITNAHFFQGLREGIF-VFLISVF 243
Cdd:COG2211  176 GDAalGYRLTALIFAVLGLLAFLLTFFGtkeRPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVaALLLYYF 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074 244 VFIETNSELALGTFGLVNSAVSFFAYYFASRLIKKKARKKSILLgGLILYGALFLILF---HMSFSTLLTYGVFIAIGYP 320
Cdd:COG2211  256 KYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFII-GLLLAALGLLLLFflgPGNLWLLLVLAALAGIGLG 334

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 752687074 321 LLLVPYVSLTYDVIGHARHARKARIE--YIVLREMFLNAGRIVSILCFLLIMAL 372
Cdd:COG2211  335 AILVLPWAMLADVVDYDEWKTGRRREglYFGIFTFAIKLGQALAGALAGLLLAL 388
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 20-324 5.57e-10

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 60.52  E-value: 5.57e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074  20 LLTIGGLYSLGIALSNTFVNVYLWKQSGKFIDLAIYNLSIVTMQPITFYLAGRLAKKIDRVFILRFGVIFLAAFylSVLL 99
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALG--ALLF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074 100 AGETAASRLVLIGAVLGVGYGFYWLAFNVLTFEITEPDTRDFFNGFMGILSSSAGMIGPIVAGFVISRLEnnTGYTVIFS 179
Cdd:cd06174   79 AFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLG--FGWRAVFL 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074 180 LSLSLFALAVVMSFFLKRRESKGR---------FMLSKVFGERHSNMNWRRITNAHFFQGLREGIFVFLISVFVFIETN- 249
Cdd:cd06174  157 IAAALALLAAILLLLVVPDPPESArakneeassKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGl 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074 250 SELALGTFGLVNSAVSFFAYYFASRLIKKKARKKSILLGGLILYGALFLILFHMSFSTLLT-----YGVFIAIGYPLLLV 324
Cdd:cd06174  237 SVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLlllllLGFGLGGLLPLSFA 316
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 17-318 4.91e-09

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 57.62  E-value: 4.91e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074  17 LLFLLTIGGLYSLGIALSNTFVNVYLWKQSGKFIDLA--IYNLSIVTMQPITFYlAGRLAKKIDRVFILRFGVIFLAAFY 94
Cdd:cd17329    1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVglVLALSAVAGIVASLI-GGRLADRFGRKPVMLAGLLLRALGF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074  95 LSVLLAGETAasrLVLIGAVL-GVGYGFYWLAFNVLTFEITEPDTRDFFNGFMGILSSSAGMIGPIVAGFVIsrlenNTG 173
Cdd:cd17329   80 ALLGFAHSPW---LFAIALVLtGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLL-----LYS 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074 174 YTVIFSLSLSLFALAVVMSFFLKRRESKGRFMLSKVFGERhsnmNWRRITNAHFFQGLREGIFVFLISVFVF-------- 245
Cdd:cd17329  152 FRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILR----GYKIVLRDRAFLLFLLASFLISLIYFQLestlpvyv 227

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 752687074 246 --IETNSELALGTFGLVNSAVSFFAYYFASRLIKKKARKKSILLGGLILYGALFLILFHMSFSTLLTYGVFIAIG 318
Cdd:cd17329  228 veILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLG 302
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
2-193 5.21e-09

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 57.99  E-value: 5.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074   2 SKLKKVIGDVDVNKGLLFLLTIGGLYSLGIALSNTFVN---VYLWKQSGKFIdlAIYNLSIVTMQPITFYLAGRLAKKID 78
Cdd:COG2211  215 VSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLyyfKYVLGLSAALV--GLLLALYFLAALLGAPLWPRLAKRFG 292

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074  79 RVFILRFGVIFLAAFYLSVLLAGETAASRLVLIGAVLGVGYGFYWLAFNVLTFEITEPDTRD-------FFNGFMGILSS 151
Cdd:COG2211  293 KKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKtgrrregLYFGIFTFAIK 372

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 752687074 152 SAGMIGPIVAGFVISRLENNTGYT----VIFSLSLSLFALAVVMSF 193
Cdd:COG2211  373 LGQALAGALAGLLLALFGYVAGAAqspsALTGIRLLFFLLPAVLLL 418
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 2-196 5.49e-09

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 57.59  E-value: 5.49e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074   2 SKLKKVIGDVDVNKGLLFLLTIGGLYSLGIALSNTFVNVYLwKQSGKF--IDLAIYNLSIVTMQPITFYLAGRLAKKIDR 79
Cdd:cd17325  186 ARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYA-AELGGLspAQIGLLFGAQGLASALSQPPAGKLSDRIGR 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074  80 VFILRFGVIFLAAFYLSVLLAGETAAsrLVLIGAVLGVGYGFYWLAFNVLTFEITEPDTRDFFNGFMGILSSSAGMIGPI 159
Cdd:cd17325  265 KPLILIGLLLSAVALLLLPLATSFWL--LLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPL 342

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 752687074 160 VAGFVISRLenntGYTVIFSLSLSLFALAVVMSFFLK 196
Cdd:cd17325  343 LGGFLYDAF----GFATPFLAAAALLLLAAVLFLLLR 375
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 52-187 2.79e-07

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 52.23  E-value: 2.79e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074  52 LAIYNLSIVTMQpitfYLAGRLAKKIDRVFILRFGVIFLAAFYLSVLLAGETAAsrLVLIGAVLGVGYGFYWLAFNVLTF 131
Cdd:cd17329  242 LALNALLIVLLQ----FPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAV--LILAMIVLTLGEMLVFPAVQTLVA 315

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 752687074 132 EITEPDTRDFFNGFMGILSSSAGMIGPIVAGFVISRLENNTGYTVIFSLSLSLFAL 187
Cdd:cd17329  316 ALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAAL 371
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 2-196 2.88e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 52.21  E-value: 2.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074   2 SKLKKVIGDVDVNKGLLFLLTIGGLYSLGIALSNTFVNVY----LWKQSGKFidLAIYNLSIVTMQPITfylaGRLAKKI 77
Cdd:cd17489  181 AEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYaaerGISNAGLF--FTVYAIALLLSRPFS----GKLSDRK 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074  78 DRVFILRFGVIFLAAFYlsVLLAGETAASRLVLIGAVLGVGYGFYWLAFNVLTFEITEPDTRDFFNGFMGILSSSAGMIG 157
Cdd:cd17489  255 GPKTVIIPGLLLLALGL--LLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLG 332

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 752687074 158 PIVAGFVISrlenNTGYTVIFSLSLSLFALAVVMSFFLK 196
Cdd:cd17489  333 GLLLGLVAE----LFGYRAMFLLAAVVVLLALVLYIFLL 367
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 69-318 4.57e-06

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 48.38  E-value: 4.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074  69 LAGRLAKKIDRVFILRFGVIFLAAFYLSVLLAGETAASRLVLIGA---VLGVGYGFYWLAFNVLTFEITEPDTRDFFNGF 145
Cdd:cd06173   53 FAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVlafLLGIASAFFGPARQALLPELVPKEQLVRANAL 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074 146 MGILSSSAGMIGPIVAGFVISRLenntGYTVIFSLSLSLFALAVVMSFFLKRRE-----SKGRFMLSKVFGERHSNMNWR 220
Cdd:cd06173  133 NSLATQLARIIGPALGGLLVALL----GPGGAFAINALSFLLSALLLLFIRRPPpaapgESSSLLLRDLREGLRYLRRSP 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074 221 RITNAHFFQGLREGIFVFLISVFV-FIETNSELALGTFGLVNSAVS---FFAYYFASRLIKKKARKKSILLGGLILygAL 296
Cdd:cd06173  209 LLRLLLLALALFALLGGALTVLLPlLAKEVLGGGAAGYGLLLAAFGvgaLLGALLLGRLSKRRRRGRLLLIGALLL--GL 286

                        250       260
                 ....*....|....*....|..
gi 752687074 297 FLILFHMSFSTLLTYGVFIAIG 318
Cdd:cd06173  287 ALLVLGLSPSLWLLLAALFLLG 308
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
68-201 5.02e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 48.33  E-value: 5.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074  68 YLAGRLAKKIDR--VFILRFGVIFLAAFYLSVLLAGETAAsrLVLIGAVLGVGYGFYWLAFNVLTFEITEPDTRDFFNGF 145
Cdd:COG2271  234 LLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLPSPAL--AIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGL 311

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 752687074 146 MGILSSSAGMIGPIVAGFVISRlennTGYTVIFSLSLSLFALAVVMSFFLKRRESK 201
Cdd:COG2271  312 VNTFGFLGGALGPLLVGYLLDA----TGYQAAFLLLAALALLAALLALLLLRETRK 363
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 79-327 6.66e-06

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 47.98  E-value: 6.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074  79 RVFILRFGVIFLAAFYL--SVLLAGETAASRLVLI-GAVLGVGYGFYWLAFNVLTFEITE-PDTRDFFNGFMGILSSSAG 154
Cdd:cd17332   70 RPWLLWGAIPLALLFVLlfTTPDGSGTGKLIYALItYILLDLLYTLVNIPYTALIPELTDdPEERTSLTSWRMFFATIGG 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074 155 MIGPIVAGFVISRLENNTGYTVIFSLSLSLFALAVVMSFFL---------KRRESKGRFMLSKVFGERHSNMNWRRITNA 225
Cdd:cd17332  150 LLVTVLPPPLVAYFGGGNASRGYFLTALIIGIIGIILLLICffgtrervvPPEEEKSKLPLLKSLKALLKNRPFLILLLA 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074 226 HFFQ----GLREGIFVFLIsVFVFIETNSELALGTFGLVNSAVSFFAYYFASRLIKKKArkksILLGGLILYGALFLILF 301
Cdd:cd17332  230 YLLYflafNIVNTVLVYYF-KYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKK----AFFIGLLLAILGLLLLF 304

                        250       260
                 ....*....|....*....|....*.
gi 752687074 302 HMSFSTLLTYGVFIAIGYPLLLVPYV 327
Cdd:cd17332  305 FLPPGNLVLILVLAVLAGIGYGGANL 330
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
65-323 2.09e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 46.39  E-value: 2.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074  65 ITFYLAGRLAKKIDRVFILRFGVIFLAAFYLSVLLAGETAAsrLVLIGAVLGVGYGFYWLAFNVLTFEItEPDTRDFFNG 144
Cdd:COG0738   58 LASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPL--LLLALFLLGLGLGLLDVAANPYVAAL-GPETAASRLN 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074 145 FMGILSSSAGMIGPIVAGFVISR---LENNTGYTVIFSLSLSLFALAVVMSFFLKRRESKGRFMLSKVFGERHSNMNWRR 221
Cdd:COG0738  135 LLHAFFSLGALLGPLLGGLLILLglsLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLL 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074 222 ITNAHFFQGLREGIFVFLISVFVFIETNSELALGTFGLVNSAVSFFA-YYFASRLIKKKARKK----SILLGGLILYGAL 296
Cdd:COG0738  215 GGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIgRFLGGFLLKRFGPVRllrlSALLAAVGLLLAL 294

                        250       260
                 ....*....|....*....|....*..
gi 752687074 297 FLILFHMSFSTLLTYGVFIAIGYPLLL 323
Cdd:COG0738  295 LAPGPWLALIGLALVGLGLSLMFPTIF 321
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 69-196 2.97e-05

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 46.03  E-value: 2.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074  69 LAGRLAKKIDRVFILRFGVIFLAAFYLSVLLAGETAASrLVLIGAVLGVGYGFYWLAFNVLTFEITEPDTRDFFNGFMGI 148
Cdd:cd17504  236 LAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWA-LVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTV 314

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 752687074 149 LSSSAGMIGPIVAGFVIS---------RLENNTGYTVIFSLSLSLFALAVVMSFFLK 196
Cdd:cd17504  315 LRTIGSAIGPAIAGAILTtytvsitsgGVPTEGAYVLAFLIGAALALAALLLSLLIP 371
MFS_1 pfam07690
Major Facilitator Superfamily;
17-158 4.01e-05

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 45.49  E-value: 4.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074   17 LLFLLTIGGLYSLGIALSNTFVNVYLWKQSGKFIDLAIYNLSIVTMQPitfyLAGRLAKKIDRVFILRFGVIFLAAFYLS 96
Cdd:pfam07690 206 LLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRL----LLGRLSDRLGRRRRLLLALLLLILAALG 281

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 752687074   97 VLLAGETAASRLVLIGAVL-GVGYGFYWLAFNVLTFEITEPDTRDFFNGFMGILSSSAGMIGP 158
Cdd:pfam07690 282 LLLLSLTLSSLWLLLALLLlGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 8-193 4.47e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 45.50  E-value: 4.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074   8 IGDVDVNKGLLFLLTIGGLYSLGIALSNTFVNVYLWKQSGKFIDLAIYNLSIVTMQPITFYLAGR--LAKKIDRVFILRF 85
Cdd:cd06174  196 LKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGllSDRLIGRKPLLLI 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074  86 GVIFLAAFYLSVLLAGETAAsrLVLIGAVLGVGYGFYWLAFNVLTFEITEPDTRDFFNGFMGILSSSAGMIGPIVAGFVI 165
Cdd:cd06174  276 GLLLMALGLALLLLAPSLLL--LLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLL 353

                        170       180
                 ....*....|....*....|....*...
gi 752687074 166 SRlenNTGYTVIFSLSLSLFALAVVMSF 193
Cdd:cd06174  354 AA---TFGLTGAFLVLAVLLLLAAILLL 378
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
52-318 2.11e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 43.32  E-value: 2.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074  52 LAIYNLSIVTMQPItfylAGRLAKKIDRVFILRFGVIFLAAFYLSVLLAGETAAsrLVLIGAVLGVGYGFYWLAFNVLTF 131
Cdd:COG2271   51 ASAFFLGYALGQIP----AGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQ--LLLLRFLLGLGEAGFFPAALKLIA 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074 132 EITEPDTRDFFNGFMGILSSSAGMIGPIVAGFVISRLenntGYTVIFSLSLSLFALAVVMSFFLkrreskgrFMLSKVfg 211
Cdd:COG2271  125 EWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF----GWRAAFLILGLPGLLLALLRFWL--------LALAYF-- 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074 212 erhsnmnwrritnahFFQGLREGIFVFLISVFVFIETNSELALGTFGLVNSAVSFFAYYFASRLIKKKARKKSILLGGLI 291
Cdd:COG2271  191 ---------------LVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGL 255

                        250       260
                 ....*....|....*....|....*..
gi 752687074 292 LYGALFLILFHMSFSTLLTYGVFIAIG 318
Cdd:COG2271  256 LLAALALLLLALLPSPALAIALLFLAG 282
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 15-194 5.40e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 41.82  E-value: 5.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074  15 KGLLFLLTIGGLYSLGIALSNTFVNVYLWKQSG-KFIDLAIYNLSIVTMQPITFYLAGRLAKKIDRVFILRFGVIFLAAF 93
Cdd:cd17316  177 RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGlSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGIL 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074  94 YLSVLLAGETAASRLVLIGAVLGVGYGFYWLAFNVLTFEITEPDTRDFFNGFmgilSSSAGMIGPIVAGFVISRLENNTG 173
Cdd:cd17316  257 ALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGL----SYNLGRLGGGGAPPLIALLLASTG 332

                        170       180
                 ....*....|....*....|.
gi 752687074 174 YTVIFSLSLSLFALAVVMSFF 194
Cdd:cd17316  333 GTGVPALILALLAIVALIVAL 353
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
69-201 6.51e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 41.76  E-value: 6.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074  69 LAGRLAKKIDRVFILRFGVIFLAAFYLSVLLAGETAASRLVLIGAVLGVGYGF---YWLAFNVLtfeitePDTRDFFNGF 145
Cdd:COG0738  265 LGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFptiFSLALDGL------GKRTAAAVSA 338

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 752687074 146 MGILSSSAGMIGPIVAGFVISRlennTGYTVIFSLSLSLFALAVVMSFFLKRRESK 201
Cdd:COG0738  339 VLIMGIVGGAIGPPLIGFLADA----FGLRAAFLVPLVCYLLILLLALALKRKRRK 390
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 2-121 1.28e-03

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 40.67  E-value: 1.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074   2 SKLKKVIGDVDVNKGLLFLLTIGGLYSLGIALSNTFVNVYLWKQSGKFIDLAIYNLSIVTMQPITFYLAGRLAKKIDRVF 81
Cdd:cd17332  208 LPLLKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKK 287

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 752687074  82 ILRFGVIFLAAFYLSVLLAGETAASRLVLIGAVLGVGYGF 121
Cdd:cd17332  288 AFFIGLLLAILGLLLLFFLPPGNLVLILVLAVLAGIGYGG 327
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
17-201 1.40e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 40.63  E-value: 1.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074  17 LLFLLTIGGLYSLGIALSNTFVNVYLWKQsgkfIDLAIYNLSIVTMQPITFYLAGRLAKKIDRVFILRFGVIFLAAFYLS 96
Cdd:COG2223  212 LLYFGTFGSFIGFSSWLPPYLVDQFGLSA----ATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLL 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074  97 VLLAGETAASrLVLIGAVLGVGYGFYWLAFNVLTFEITEPDTRDFFNGFMGILSSSAGMIGPIVAGFVISRLENntgYTV 176
Cdd:COG2223  288 LALALGSLWL-FLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGS---YTA 363

                        170       180
                 ....*....|....*....|....*
gi 752687074 177 IFSLSLSLFALAVVMSFFLKRRESK 201
Cdd:COG2223  364 AFLVFAVLALVALVLTLLLYRRPRR 388
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
17-154 1.71e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 40.34  E-value: 1.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074  17 LLFLLTIGGLYSLGIALSNTFVNVYLWKQSGKFIDLAIYNLSIVTMQPitfyLAGRLAKKIDRVFILRFGVIFLAAFYLS 96
Cdd:COG2814  214 LLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGAL----LAGRLADRFGRRRLLLIGLLLLALGLLL 289

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 752687074  97 VLLAGETAAsrLVLIGAVLGVGYGFYWLAFNVLTFEITEPDTRDFFNGFMGILSSSAG 154
Cdd:COG2814  290 LALAGSLWL--LLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 52-323 1.74e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 40.25  E-value: 1.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074  52 LAIYNLSIVtmqpITFYLAGRLAKKIDRVFILRFGVIFLAAFYLSVLLAGETAAsrlVLIG-AVLGVGYGFYWLAFNVLT 130
Cdd:cd17473   41 LTLPALFIA----LFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYA---LLASrALLGIGVAGIMTLATALI 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074 131 FEITEPDTRDFFNGFMGILSSSAGMIGPIVAGFVISrlennTGYTVIFSLSLSLFALAVVMSFFLKRRESKGRFMLSKVF 210
Cdd:cd17473  114 GDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-----IGWRAPFLVYLLALPVLILVLLFLPEPARKSKSAASPGA 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074 211 GERHSnMNWRRITNAHFFqglregifVFLISVFVFIE-TNSELALGTFGLVNSAVSFFAYYFAS----------RLIKKK 279
Cdd:cd17473  189 ATAAA-LPWKRVLPIYFL--------AFLAMLLFYVIpIQLPFLLQERGGGSAALIGLALAIASlagaigallfGRLKRR 259

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 752687074 280 ARKKSILLGGLILYGALFLILFHMSFSTLLTYGVFIA-IGYPLLL 323
Cdd:cd17473  260 LGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAgLGFGLLL 304
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
16-318 1.83e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 40.25  E-value: 1.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074  16 GLLFLLTIGGLYSLGIaLSNTFVNVYLWKQSGKFIDLAIYNLSIVTMQPItfylAGRLAKKIDRVFILRFGVIFLAAFYL 95
Cdd:COG2223   11 TLAFFLAFGVWYLWSV-LAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIP----LGFLVDRFGPRRVLLIGLLLLGIGLL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074  96 SVLLAGETAAsrLVLIGAVLGVGYGFYWLAFNVLTFEITEPDTRDFFNGfmgiLSSSAGMIGPIVAGFVISRLENNTGYT 175
Cdd:COG2223   86 LLALAVSYWL--LLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALG----LAAGGGNLGAAVAAFLAPLLIAAFGWR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074 176 VIFSLSLSLFALAVVMSFFLKRRESKGRFMLSK--------VFGERHsnmnWRRITNAHFFQGlreGIFVFLISVFV-FI 246
Cdd:COG2223  160 NAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKaslrdqleALRDPR----FWLLSLLYFGTF---GSFIGFSSWLPpYL 232

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 752687074 247 ETNSELALGTFGLVNSAVSFF---AYYFASRLIKKKARKKsILLGGLILYGALFLILFHMSFSTLLTYGVFIAIG 318
Cdd:COG2223  233 VDQFGLSAATAGLLAALFALLgalGRPLGGWLSDRIGGRR-VLLIVFALMALGLLLLALALGSLWLFLVLFLLLG 306
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 55-331 1.93e-03

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 40.25  E-value: 1.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074  55 YNLSIVTMQPITFYLAGRLAKKidRVFILRfgvifLAAFYLSVLLAG-ETAASRLVLIGAVLGVGYGFYW-LAFNVLtFE 132
Cdd:cd17503   40 YLLALAIMIPLSGWLADRFGTR--RLFLTA-----LALFTLGSLLCGlAPNLASLIIFRILQGFGGGVLIpLAQTIL-LR 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074 133 ITEPDTRDFFNGFMGILSSSAGMIGPIVAGFVIsrleNNTGYTVIFSLSLSLFALAVVMSFFLKRReskgrfmlskVFGE 212
Cdd:cd17503  112 IYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLT----DNLSWRWIFYINLPIGILALLLAPLLDLR----------LFKD 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074 213 RhsnmNWRRITNAHFFQGLREGIFVFLISVFVFI-----ETNSELALGTFGLvnsaVSFFAYYFASRLIKKKARKKSILL 287
Cdd:cd17503  178 R----NFTLGLLLSFLLGLGLFGAMFLLPLYLQNvlgysAFESGLVLAPGGL----ASAILSPLVGRLLDKFGPRLLLLA 249

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 752687074 288 GGLILYGALFLILF---HMSFSTLLTYGVFIAIGYPLLLVPYVSLTY 331
Cdd:cd17503  250 GLLLLALGTLLLAFltpDTSLWLIILPLFIRGLGMGLVFMPLNTLAL 296
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 64-307 2.02e-03

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 39.79  E-value: 2.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074  64 PITFYLAGRLAKKIDRVFILRFGVIFLAAFYLSVLLAGETAAsrLVLIGAVLGVGYGFYWLAFNVLTFEITEPDTRDFFN 143
Cdd:COG0477   63 AIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPEL--LIAARALQGIGAGGLMPGALALIAELFPARERGRAL 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074 144 GFMGILSSSAGMIGPIVAGFVISRLenntGYTVIFSLSLSLFALAVVMSFFLKrrESKGRFMLSKVFGERHSnmnWRRIT 223
Cdd:COG0477  141 GLWGAAIGLGLALGPLLGGLLVAAL----GWRWIFLINAPLGLLALVLRLRLP--ESRGLLLALLALALAAL---LLAAL 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074 224 NAHFFQGLREGIFVFLISVFVFIETNSELALGTFGLVNSAVSFFAYYFASRLIKKKARKKSILLGGLILYGALFLILFHM 303
Cdd:COG0477  212 ALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLL 291


                 ....
gi 752687074 304 SFST 307
Cdd:COG0477  292 ALLL 295
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 69-329 4.53e-03

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 39.10  E-value: 4.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074  69 LAGRLAKKIDRVFILrfgVIFLAAFYLSVLLAGETAASRLVLIG-AVLGVGYGFYWLAFNVLTFEITEPDTRdffnGFMG 147
Cdd:cd17504   50 ILGRLGDLYGRKKVL---LIVLAIYTAGSLLAAFAPNLPVLIAGrALQGIGGAVFPLAFALVREEFPPERVP----VAQG 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074 148 ILSSSAG---MIGPIVAGFVIsrleNNTGYTVIFSLSLSLFALAVVMSFFLKRRESKGRFMLSkvfgerhSNMnwrritn 224
Cdd:cd17504  123 ILSATFGigaGIGLPLGGWIV----QHLGWRWIFWTAAPVAVLLAALVPLIDLRLLRRRNVLL-------ANI------- 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074 225 AHFFQGLreGIFVFLISVFVFIETNSELALG----TFGLV---NSAVSFFAYYFASRLIKKKARKKSILLGGLI-LYGAL 296
Cdd:cd17504  185 TALLAGF--GMFMVFQLLPQLLQLPTPTGFGlgitEAGLLllpGALVMLIAGPLAGRLIARVGPRRVLLIGLVIsAVGLL 262

                        250       260       270
                 ....*....|....*....|....*....|...
gi 752687074 297 FLILFHMSFSTLLTYGVFIAIGYPLLLVPYVSL 329
Cdd:cd17504  263 LLALLHSSLWALVVALLLIGIGLGLAFASLPNI 295
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 69-328 6.79e-03

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 38.44  E-value: 6.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074  69 LAGRLAKKIDRVFILRFGVIFLAAFylSVLLAGETAASRLVLIGAVLGVGYGFYWLAFNVLTFEITEPDTRDFFNGFMGI 148
Cdd:cd17371   53 LGGILADRFGRVRVLVITILLFAVF--TLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQS 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074 149 LSSSAGMIGPIVAGFVISRLENNTGYTVIFSLSLSLFALAVVMSFFLK-----------RRESKGRFMLSKVFGERHSNM 217
Cdd:cd17371  131 GWAVGWLLATLLAALLFPLLPPEIAWRVLFLLGALPALLVLFIRRFVKeppqwqaaraaRRHFADRPSLRELFSPPLLRT 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752687074 218 NWRRITNAHFFQGLREGIFVFLISvfvFIETNSELALGTFGLVNS---AVSFFAYYFASRLIKKKARKKSILLGGLILYG 294
Cdd:cd17371  211 TLLASLLATGALGGYYGITTWLPS---YLTGERGLSFEGSAGYLVvtiLGGFLGYLAGGFLADRIGRRNNFALFALGSAI 287

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 752687074 295 ALFLILF-HMSFSTLLTYGV---FIAIGYPLLLVPYVS 328
Cdd:cd17371  288 SILLYFFlPLSPTLILILGFplgFFASGPFSGMGAYLT 325
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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