|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
1-477 |
0e+00 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 891.82 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 1 MAAKRPFSLATRLTFFISLATIIAFFAFTWIMIHSVKAHFEERDVHDLRQLSTTLETVLNHADYPQARRLEIVRNIIAGY 80
Cdd:PRK09835 4 KPFQRPFSLATRLTFFISLATIAAFFAFTWIMIHSVKVHFAEQDINDLKQISATLERVLNHPDETQARRLMTLEDIVAGY 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 81 ANVFICLDDGQGNILFQSPDGPDLSHMLSTPGLAMQLRDGNVISWTDPQPRKMVHDNHPMETRAWRLIMLPLGKQADGKP 160
Cdd:PRK09835 84 SNVLISLADSHGKTVYHSPGAPDLREFVRDAIPDKDARGGEVFLWSGPTPMMPGHGHGHMEHSNWRMIALPVGPLVDGKP 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 161 AYHLLMALSIDFHLHYINELKAKLISAATIISLLIIAIVLFVVYQGHKPIRQISRQIQNITSRDLDVRLDPQAVPIELER 240
Cdd:PRK09835 164 IYTLLIALSIDFHLHYINDLKNKLIMTASVISLLIVFIVLLAVHKGHAPIRSVSRQIQNITSKDLDVRLDPQTVPIELEQ 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 241 LALSFNHMLERIEDVFTRQSNFSADIAHEIRTPITNLVTQTEIALSQSRSQQELEEVLYSNLEEFSRMSRMVSDMLFLAQ 320
Cdd:PRK09835 244 LVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEIALSQSRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQ 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 321 ADNNQLIPEQQALDLADEVHKVFEFFEAWAEEKAVALRFVGSHCRVTGDPLMLRRAISNLLSNAIRYTPAGQAVTIQLSE 400
Cdd:PRK09835 324 ADNNQLIPEKKMLDLADEVGKVFDFFEAWAEERGVELRFVGDPCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQE 403
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 751262903 401 SAETIRLVVENPGTPIAAEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVSAHHGSVAVQSDRRSTRFIVVLPK 477
Cdd:PRK09835 404 VDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDARGTRFVISLPR 480
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
6-476 |
2.65e-167 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 479.58 E-value: 2.65e-167
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 6 PFSLATRLTFFISLATIIAFFAFTWIMIHSVKAHFEERDVHDLRQLSTTLETVLNHADYPQ---ARRLEIVRNIIAGYAN 82
Cdd:TIGR01386 1 PRSLTLRLALLFAAVTALVFALSGFMLYSSLERHFEERDREELQGKLEQVRRFLRDPADLDediKRLQEKIDDLLVGHSD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 83 VFICLDDGQGNILFQSPDGPDLSHmLSTPGLAMQLRDgnviswtdPQPRKMVHDNHPMEtrawRLIMLPLGKqadGKPAY 162
Cdd:TIGR01386 81 LALSILNPDGRLLFERAQGAALVP-AVAANDALLELD--------QADAKMTHYRSILR----SVAALPGGK---GRKPV 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 163 HLLMALSIDFHLHYINELKAKLISAATIISLLIIAIVLFVVYQGHKPIRQISRQIQNITSRDLDVRLDPQAVPIELERLA 242
Cdd:TIGR01386 145 QITVALDINAHTHLLDALRKWLILIAVLLVLLTALLGWWITRLGLEPLRRLSAVAARISPESLDQRLDPSRAPAELRELA 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 243 LSFNHMLERIEDVFTRQSNFSADIAHEIRTPITNLVTQTEIALSQSRSQQELEEVLYSNLEEFSRMSRMVSDMLFLAQAD 322
Cdd:TIGR01386 225 QSFNAMLGRLEDAFQRLSQFSADLAHELRTPLTNLLGQTQVALSQPRTGEEYREVLESNLEELERLSRMVSDMLFLARAD 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 323 NNQLIPEQQALDLADEVHKVFEFFEAWAEEKAVALRFVGShCRVTGDPLMLRRAISNLLSNAIRYTPAGQAVTIQLSESA 402
Cdd:TIGR01386 305 NGQLALERVRLDLAAELAKVAEYFEPLAEERGVRIRVEGE-GLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRS 383
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 751262903 403 ETIRLVVENPGTPIAAEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVSAHHGSVAVQSDRRSTRFIVVLP 476
Cdd:TIGR01386 384 DEVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDGKTRFILRFP 457
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
140-477 |
6.80e-70 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 227.51 E-value: 6.80e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 140 METRAWRLIMLPLGKQADGKPAYHLLMALSIDFHLHYINELKAKLISAATIISLLIIAIVLFVVYQGHKPIRQISRQIQN 219
Cdd:COG5002 46 LLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELL 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 220 ITSRDLDVRLDPQAVPIELERLALSFNHMLERIEDVFTRQSNFSADIAHEIRTPITNLVTQTEIALSQ-SRSQQELEEVL 298
Cdd:COG5002 126 LLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGaADDPEERREYL 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 299 YSNLEEFSRMSRMVSDMLFLAQADNNQLIPEQQALDLADEVHKVFEFFEAWAEEKAVALRF--VGSHCRVTGDPLMLRRA 376
Cdd:COG5002 206 EIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELdlPEDPLLVLGDPDRLEQV 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 377 ISNLLSNAIRYTPAGQAVTIQLSESAETIRLVVENPGTPIAAEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVSAH 456
Cdd:COG5002 286 LTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAH 365
|
330 340
....*....|....*....|..
gi 751262903 457 HGSVAVQSDRRS-TRFIVVLPK 477
Cdd:COG5002 366 GGRIWVESEPGKgTTFTITLPL 387
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
164-477 |
3.89e-65 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 213.23 E-value: 3.89e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 164 LLMALSIDFHLHYINELKAKLISAATIISLLIIAIVLFVVYQGHKPIRQISRQIQNITSRDLDVRLDPQAVPIELERLAL 243
Cdd:COG0642 15 LLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 244 SFNHMLERIEDVFTRQSNFSADIAHEIRTPITNLVTQTEIALSQ-SRSQQELEEVLYSNLEefsRMSRMVSDMLFLAQAD 322
Cdd:COG0642 95 LLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEElDEEQREYLETILRSAD---RLLRLINDLLDLSRLE 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 323 NNQLIPEQQALDLADEVHKVFEFFEAWAEEKAVALRFV--GSHCRVTGDPLMLRRAISNLLSNAIRYTPAGQAVTIQLSE 400
Cdd:COG0642 172 AGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDlpDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRR 251
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 751262903 401 SAETIRLVVENPGTPIAAEHLPRLFDRFYRVDPSrqRKGEGSGIGLAIVKSIVSAHHGSVAVQSDR-RSTRFIVVLPK 477
Cdd:COG0642 252 EGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPS--RRGGGTGLGLAIVKRIVELHGGTIEVESEPgKGTTFTVTLPL 327
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
246-477 |
1.20e-59 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 195.90 E-value: 1.20e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 246 NHMLERIEDVFTRQSNFSADIAHEIRTPITNLVTQTEIALSQ-SRSQQELEEVLYSNLEEFSRMSRMVSDMLFLAQADNN 324
Cdd:COG2205 3 EEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEeDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLESG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 325 QLIPEQQALDLADEVHKVFEFFEAWAEEKAVALRFV--GSHCRVTGDPLMLRRAISNLLSNAIRYTPAGQAVTIQLSESA 402
Cdd:COG2205 83 KLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDlpPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREG 162
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 751262903 403 ETIRLVVENPGTPIAAEHLPRLFDRFYRVDpsRQRKGEGSGIGLAIVKSIVSAHHGSVAVQSDRRS-TRFIVVLPK 477
Cdd:COG2205 163 DGVRISVSDNGPGIPEEELERIFERFYRGD--NSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGgTTFTVTLPL 236
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
176-462 |
4.51e-40 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 150.38 E-value: 4.51e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 176 YINELKAKLISAATIISLLIIAIVLFVVYQGHKPIRQISRQIQNITsrdldvrlDPQAVPI------ELERLALSFNHML 249
Cdd:PRK11100 176 FIKRSERRILWAGALLLGIALLIGAGVVWWLNRSIRRLTRYADAVT--------EGKPVPLpklgssELRELAQALESMR 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 250 ERIEDvftRQ--SNFSADIAHEIRTPITNLVTQTEIaLSQSRSQQELEEVLYSNLEEFSRMSRMVSDMLFLAQADNNQLI 327
Cdd:PRK11100 248 VKLEG---KAyvEQYVQTLTHELKSPLAAIRGAAEL-LQEDPPPEDRARFTGNILTQSARLQQLIDRLLELARLEQRQEL 323
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 328 PEQQALDLADEVHKVFEFFEAWAEEKAVALRFVGSHCRVTGDPLMLRRAISNLLSNAIRYTPAGQAVTIQLSESAETIRL 407
Cdd:PRK11100 324 EVLEPVALAALLEELVEAREAQAAAKGITLRLRPDDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVAL 403
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 751262903 408 VVENPGTPIAAEHLPRLFDRFY---RvdPSRQRKgeGSGIGLAIVKSIVSAHHGSVAV 462
Cdd:PRK11100 404 SVEDQGPGIPDYALPRIFERFYslpR--PANGRK--STGLGLAFVREVARLHGGEVTL 457
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
144-460 |
6.23e-38 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 144.02 E-value: 6.23e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 144 AWRLIMLplgKQADGKpaYHLL----------MALSIdfhlhyineLKAKLISaaTIISLLIIAIVLFV-VYQGHKPIRQ 212
Cdd:PRK10337 128 LWRFVWL---TSPDGK--YRIVvgqeweyredMALAI---------VAGQLIP--WLVALPIMLIILMVlLGRELAPLKK 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 213 ISRQIQnITSRDLDVRLDPQAVPIELERLALSFNHMLERIEDVFTRQSNFSADIAHEIRTPITNLVTQTEIA-LSQSRSQ 291
Cdd:PRK10337 192 LALALR-MRDPDSETPLNATGVPSEVRPLVEALNQLFARTHAMMVRERRFTSDAAHELRSPLAALKVQTEVAqLSDDDPQ 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 292 qeLEEVLYSNLEE-FSRMSRMVSDMLFLAQADNNQLIPEQQALDLADEVHK-VFEFFE-AWAEEKAVALRFVGSHCRVTG 368
Cdd:PRK10337 271 --ARKKALLQLHAgIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSaVMDIYHtAQQAGIDVRLTLNAHPVIRTG 348
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 369 DPLMLRRAISNLLSNAIRYTPAGQAVTIQLSESaetiRLVVENPGTPIAAEHLPRLFDRFYRvdPSRQRKgEGSGIGLAI 448
Cdd:PRK10337 349 QPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNAR----NFTVRDNGPGVTPEALARIGERFYR--PPGQEA-TGSGLGLSI 421
|
330
....*....|..
gi 751262903 449 VKSIVSAHHGSV 460
Cdd:PRK10337 422 VRRIAKLHGMNV 433
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
189-477 |
1.40e-37 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 140.90 E-value: 1.40e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 189 TIISLlIIAIVL---FVVyqghkPIRQISRQIQNITSRDLDVRLDPQAV-PIELERLALSFNHMLERIEDVFTRQSNFSA 264
Cdd:NF012226 70 SVISL-IIGMKLaqrFIV-----PINFLADAAKKISQGDLSARAEDSQIhSAEISELMHNFNDMAQKLESSVKNAQVWNA 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 265 DIAHEIRTPITNLvtqteialsQSRSQQ------ELEEVLYSN-LEEFSRMSRMVSDMLFLAQADNNQLIPEQQALDLAD 337
Cdd:NF012226 144 AIAHELRTPITIL---------QGRLQGildgvfEPDPALFKSlLNQVEGLSHLVEDLRTLSLVENQQLRLNYESVDLKD 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 338 EVHKVFEFFEAWAEEKAVALRFVGSHCRVTGDPLMLRRAISNLLSNAIRYTPAGQaVTIQLSESAETIRLVVENPGTPIA 417
Cdd:NF012226 215 SIEKVLKMFEDRLEQAQLTIVLNLTATPVFCDRRRIEQVLIALIDNAIRYANAGK-LKISSSVIQDDWILQIEDEGPGIA 293
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 418 AEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVSAHHGSVAVQSDRRSTRFIVVLPK 477
Cdd:NF012226 294 EEYQQDLFNPFFRLEQSRNKEFGGTGLGLAVVHAIVIAHKGSIEYSNSQGNSVFTIKLPA 353
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
159-476 |
1.92e-37 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 142.66 E-value: 1.92e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 159 KPAYHLLMALSIDFhlhYINELKAKLISAAtiISLLIIAIVLFVVYQG-HKPIRQISRQIQNITSRDLDVRLDPQAVPiE 237
Cdd:NF012163 145 SPVERLTRNTDINF---DSQQKRASWLIVA--LALLLAALAAFLLARGlLAPVKRLVEATHRLAAGDYTTRVTPTSND-E 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 238 LERLALSFNHMLERIEDVFTRQSNFSADIAHEIRTPITnlVTQTEIALSQSRSQQELEEVLYSNLEEFSRMSRMVSDMLF 317
Cdd:NF012163 219 LGKLAQDFNQLASTLEKNEQMRRDFMADISHELRTPLA--VLRAELEAIQDGIRKFTPESLDSLQAEVGTLTKLVDDLHD 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 318 LAQADNNQLIPEQQALDLADEVHKVFEFFEAWAEEKAVALRFVG-SHCRVTGDPLMLRRAISNLLSNAIRYTPAGQAVTI 396
Cdd:NF012163 297 LSMSDEGALAYQKASVDLVPLLEVEGGAFRERFASAGLELEVSLpDSSLVFGDRDRLMQLFNNLLENSLRYTDSGGSLHI 376
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 397 QLSESAETIRLVVENPGTPIAAEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVSAHHGSV-AVQSDRRSTRFIVVL 475
Cdd:NF012163 377 SASQRPKEVTLTVADSAPGVSDEQLARLFERFYRVEVSRNRASGGSGLGLAISLNIVQAHGGTLhAAHSPLGGLRIVVTL 456
|
.
gi 751262903 476 P 476
Cdd:NF012163 457 P 457
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
261-477 |
3.02e-36 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 138.99 E-value: 3.02e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 261 NFSADIAHEIRTPITNLVTQTEIALSQSRSQQELEEVLYSNLEEFSRMSRMVSDMLFL------AQADNNQL--IP---- 328
Cdd:PRK11006 206 NFFANVSHELRTPLTVLQGYLEMMQDQPLEGALREKALHTMREQTQRMEGLVKQLLTLskieaaPTIDLNEKvdVPmmlr 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 329 --EQQALDLADEVHK-VFEffeawaeekavalrfVGSHCRVTGDPLMLRRAISNLLSNAIRYTPAGQAVTIQLSESAETI 405
Cdd:PRK11006 286 vlEREAQTLSQGKHTiTFE---------------VDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPQGA 350
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 751262903 406 RLVVENPGTPIAAEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVSAHHGSVAVQSDR-RSTRFIVVLPK 477
Cdd:PRK11006 351 EFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVgKGTRFSFVLPE 423
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
160-476 |
5.09e-34 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 132.80 E-value: 5.09e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 160 PAYHLLMALSIDFHLHYINELKakLISAATIISL-LIIAIVLFVVYQGH-KPIRQISRQIQNITSRDLDVR--LDPQAvp 235
Cdd:PRK10604 114 PRSHYVLAVGPVPYLYYLHQMR--LLDIALLALIgLSLAFPVFLWMRPHwQDMLKLEAAAQRLGDGHLAERihFDEGS-- 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 236 iELERLALSFNHMLERIEDVFTRQSNFSADIAHEIRTPITNLvtQTEIALSQSRSQQELEEVlysNlEEFSRMSRMVSDM 315
Cdd:PRK10604 190 -SLERLGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRL--RYRLEMSDNLSAAESQAL---N-RDIGQLEALIEEL 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 316 LFLAQADNNQLIPEQQALDLADEVHKVFEFFEAWAEEKAVALRFVGSHCRVTGDPLMLRRAISNLLSNAIRYtpAGQAVT 395
Cdd:PRK10604 263 LTYARLDRPQNELHLSEPDLPAWLSTHLADIQAVTPEKTVRLDTPHQGDYGALDMRLMERVLDNLLNNALRY--AHSRVR 340
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 396 IQLSESAETIRLVVENPGTPIAAEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVSAHHGSVAV-QSDRRSTRFIVV 474
Cdd:PRK10604 341 VSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCdESELGGARFSFS 420
|
..
gi 751262903 475 LP 476
Cdd:PRK10604 421 WP 422
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
373-475 |
5.06e-33 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 120.79 E-value: 5.06e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 373 LRRAISNLLSNAIRYTPAGQAVTIQLSESAETIRLVVENPGTPIAAEHLPRLFDRFYRVDPSRQrkGEGSGIGLAIVKSI 452
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSRE--GGGTGLGLAIVRRI 78
|
90 100
....*....|....*....|....
gi 751262903 453 VSAHHGSVAVQSDRRS-TRFIVVL 475
Cdd:cd00075 79 VEAHGGRITVESEPGGgTTFTVTL 102
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
368-477 |
3.37e-32 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 118.91 E-value: 3.37e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 368 GDPLMLRRAISNLLSNAIRYTPAGQAVTIQLSESAETIRLVVENPGTPIAAEHLPRLFDRFYRVDPsRQRKGEGSGIGLA 447
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|.
gi 751262903 448 IVKSIVSAHHGSVAVQSDRRS-TRFIVVLPK 477
Cdd:smart00387 80 IVKKLVELHGGEISVESEPGGgTTFTITLPL 110
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
266-477 |
6.51e-32 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 126.62 E-value: 6.51e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 266 IAHEIRTPITNlvtqteIALSQSRSQQELEEVLYSNLEEF-----------SRMSRMVSDMLFLAQADNNQLipeqQALD 334
Cdd:COG5000 208 IAHEIKNPLTP------IQLSAERLRRKLADKLEEDREDLeraldtiirqvDRLKRIVDEFLDFARLPEPQL----EPVD 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 335 LADEVHKVFEFFEAWAEEKAVALRF--VGSHCRVTGDPLMLRRAISNLLSNAIRYTPAGQAVTIQLSESAETIRLVVENP 412
Cdd:COG5000 278 LNELLREVLALYEPALKEKDIRLELdlDPDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDN 357
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 751262903 413 GTPIAAEHLPRLFDRFYrvdpsrQRKGEGSGIGLAIVKSIVSAHHGSVAVQSDRRS-TRFIVVLPK 477
Cdd:COG5000 358 GPGIPEEVLERIFEPFF------TTKPKGTGLGLAIVKKIVEEHGGTIELESRPGGgTTFTIRLPL 417
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
263-476 |
1.24e-30 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 121.83 E-value: 1.24e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 263 SADIAHEIRTPITNLVTQTEIA---LSQSRSQQELEEVLYSNLEEFSRMSRMVSDMLFLAQADNnqliPEQQALDLADEV 339
Cdd:COG4191 146 AAGIAHEINNPLAAILGNAELLrrrLEDEPDPEELREALERILEGAERAAEIVRSLRAFSRRDE----EEREPVDLNELI 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 340 HKVFEFFEAWAEEKAVALRFVGSH--CRVTGDPLMLRRAISNLLSNAIRYTPAGQA--VTIQLSESAETIRLVVENPGTP 415
Cdd:COG4191 222 DEALELLRPRLKARGIEVELDLPPdlPPVLGDPGQLEQVLLNLLINAIDAMEEGEGgrITISTRREGDYVVISVRDNGPG 301
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 751262903 416 IAAEHLPRLFDRFYrvdpSRQRKGEGSGIGLAIVKSIVSAHHGSVAVQSDR-RSTRFIVVLP 476
Cdd:COG4191 302 IPPEVLERIFEPFF----TTKPVGKGTGLGLSISYGIVEKHGGRIEVESEPgGGTTFTITLP 359
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
1-477 |
3.47e-30 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 122.97 E-value: 3.47e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 1 MAAKRPFSLATRLTFFISLATIIAFFAFTWIMIHSVKAHFEERDVHDLRQLSTTLETVLNHADYPQARRLEIVRNIIAGY 80
Cdd:COG4251 17 LLLLLLLLLLVLLLALALLLLLALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALALLLLLLLLELALVLLAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 81 ANVFICLDDGQGNILFQSPDGPDLSHMLSTPGLAMQLRDGNVISWTDPQPRKMVHDNHPMETRAWRLIMLPLGKQADGKP 160
Cdd:COG4251 97 LLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALA 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 161 AYHLLMALSIDFHLHYINELKAKLISAATIISLLIIAIVLFVVYQGHKPIRQISRQIQNITSRDLDVRLDPQAVPIELER 240
Cdd:COG4251 177 ELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLE 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 241 LALSFNHMLERIEDVFT--RQSN-----FSADIAHEIRTPITNLVTQTEIAlsqsrsQQELEEVLYSNLEEF-------- 305
Cdd:COG4251 257 LRLELEELEEELEERTAelERSNeeleqFAYVASHDLREPLRKISGFSQLL------EEDYGDKLDEEGREYlerirdaa 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 306 SRMSRMVSDMLFLAQADNNQLIPEQqaLDLADEVHKVFEFFEAWAEEKAVALRfVGSHCRVTGDPLMLRRAISNLLSNAI 385
Cdd:COG4251 331 ERMQALIDDLLAYSRVGRQELEFEP--VDLNELLEEVLEDLEPRIEERGAEIE-VGPLPTVRGDPTLLRQVFQNLISNAI 407
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 386 RYTPAGQAVTIQLS--ESAETIRLVVENPGTPIAAEHLPRLFDRFYRVDPSRQRkgEGSGIGLAIVKSIVSAHHGSVAVQ 463
Cdd:COG4251 408 KYSRPGEPPRIEIGaeREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRDEY--EGTGIGLAIVKKIVERHGGRIWVE 485
|
490
....*....|....*
gi 751262903 464 SDR-RSTRFIVVLPK 477
Cdd:COG4251 486 SEPgEGATFYFTLPK 500
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
191-476 |
1.46e-29 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 120.51 E-value: 1.46e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 191 ISLLIIAIVLFVVYQGH-KPIRQISRQIQNITSRDLDVRLDPQAVPiELERLALSFNHM---LERIEDVftrQSNFSADI 266
Cdd:PRK10549 172 LSTLLAALATFLLARGLlAPVKRLVEGTHKLAAGDFTTRVTPTSRD-ELGRLAQDFNQLastLEKNEQM---RRDFMADI 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 267 AHEIRTPITNLVTQTEiALsQSRSQQELEEVLYSNLEEFSRMSRMVSDMLFLAQADNNQLIPEQQALDLADEVHKVFEFF 346
Cdd:PRK10549 248 SHELRTPLAVLRGELE-AI-QDGVRKFTPESVASLQAEVGTLTKLVDDLHQLSLSDEGALAYRKTPVDLVPLLEVAGGAF 325
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 347 EAWAEEKAVALRF-VGSHCRVTGDPLMLRRAISNLLSNAIRYTPAGQAVTIQLSESAETIRLVVENPGTPIAAEHLPRLF 425
Cdd:PRK10549 326 RERFASRGLTLQLsLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLF 405
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 751262903 426 DRFYRVDPSRQRKGEGSGIGLAIVKSIVSAHHGSV-AVQSDRRSTRFIVVLP 476
Cdd:PRK10549 406 ERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIiAAHSPFGGVSITVELP 457
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
175-477 |
2.64e-29 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 117.76 E-value: 2.64e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 175 HYINELKAKLIsaatIISLLIIAIVLFVVYQGHK----PIRQISRQIQNITSRDLDvRLDPQAVPIELERLALSFNHMLE 250
Cdd:PRK10755 54 KEIREAVASLL----VPSLVMVSLTLLICFQAVRwitrPLAELQKELEARTADNLT-PIAIHSSTLEIEAVTSALNQLVS 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 251 RIEDVFTRQSNFSADIAHEIRTPITNLVTQTEIaLSQSRSQQEleEVLYSNLEefsRMSRMVSDMLFLAQADNNQLIPEQ 330
Cdd:PRK10755 129 RLTSTLDQERLFTADVAHELRTPLAGIRLHLEL-LEKQHHIDV--APLIARLD---QMMHTVEQLLQLARAGQSFSSGHY 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 331 QALDLADEVHK-VFEFFEAWAEEKAVALRF--VGSHCRVTGDPLMLRRAISNLLSNAIRYTPAGQAVTIQLSESAETIRL 407
Cdd:PRK10755 203 QTVKLLEDVILpSQDELSEMLEQRQQTLLLpeSAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGAVL 282
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 751262903 408 VVENPGTPIAAEHLPRLFDRFYRVDpsrQRKGeGSGIGLAIVKSIVSAHHGSVAVQ--SDRRSTRFIVVLPK 477
Cdd:PRK10755 283 AVEDEGPGIDESKCGELSKAFVRMD---SRYG-GIGLGLSIVSRITQLHHGQFFLQnrQERSGTRAWVWLPK 350
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
368-476 |
1.47e-27 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 105.91 E-value: 1.47e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 368 GDPLMLRRAISNLLSNAIRYTPAGQAVTIQLSEsAETIRLVVENPGTPIAAEHLPRLFDRFYRVDpsrQRKGEGSGIGLA 447
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSE-GGELTLTVEDNGIGIPPEDLPRIFEPFSTAD---KRGGGGTGLGLS 76
|
90 100 110
....*....|....*....|....*....|
gi 751262903 448 IVKSIVSAHHGSVAVQS-DRRSTRFIVVLP 476
Cdd:pfam02518 77 IVRKLVELLGGTITVESePGGGTTVTLTLP 106
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
369-476 |
2.82e-27 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 105.24 E-value: 2.82e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 369 DPLMLRRAISNLLSNAIRYTPAGQAVTIQLSESAETIRLVVENPGTPIAAEHLPRLFDRFYRVDPSRQRKGEGSGIGLAI 448
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 751262903 449 VKSIVSAHHGSV-AVQSDRRSTRFIVVLP 476
Cdd:cd16946 81 CHNIALAHGGTIsAEHSPLGGLRLVLTLP 109
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
373-476 |
1.65e-26 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 103.05 E-value: 1.65e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 373 LRRAISNLLSNAIRYTPAGQAVTIQLSESAETIRLVVENPGTPIAAEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSI 452
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHV 80
|
90 100
....*....|....*....|....*
gi 751262903 453 VSAHHGSVAVQSDR-RSTRFIVVLP 476
Cdd:cd16952 81 MSRHDARLLIASELgKGSRFTCLFP 105
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
12-476 |
3.04e-26 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 110.79 E-value: 3.04e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 12 RLTFFISLAT-IIAFFAFTW-------IMIHsvkaHFEERDVHDLrqlsttletvlnhADYPQARRLEIVRNIIAGYANv 83
Cdd:PRK09470 2 RLPMINSLTArIFAIFWLTLalvlmlvLMLP----KLDSRQMTEL-------------LDSEQRQGLMIEQHIEAELAN- 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 84 ficlDDGQGNILFQ---------SPDGPDLshMLSTPglamqlrDGNVISwTDPQPRKMVH------DN--HPMETRAWR 146
Cdd:PRK09470 64 ----DPPNDLMWWRrlfraidkwAPPGQRL--LLVTS-------EGRIIG-AERSEMQAVRnfigqsDNadHPQKKKYGR 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 147 LIMLPLGKQADGKPAYHLLMALSIDF-HLHYINELKAK--LISAATIisLLIIAIVLFVVYQGHKPIRQISRQIQNITSR 223
Cdd:PRK09470 130 VEIVGPFSVRDGEDNYQLYLIRPANSpQSDFINLLFDRplLLLLVTM--LVSTPLLLWLAWSLAKPARKLKNAADEVAQG 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 224 DLDVRLDPQAVPIELERLALSFNHMLERIEDVFTRQSNFSADIAHEIRTPITNLVTQTEIALSQSRSQQELEEVlysnlE 303
Cdd:PRK09470 208 NLRQHPELETGPQEFRQAGASFNQMVTALERMMTSQQRLLSDISHELRTPLTRLQLATALLRRRQGESKELERI-----E 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 304 -EFSRMSRMVSDMLFLA--QADNNQLIPEQQALDLADEVHKVFEFfEAwaEEKAVALRFVGSHCR--VTGDPLMLRRAIS 378
Cdd:PRK09470 283 tEAQRLDSMINDLLVLSrnQQKNHLERETFKANSLWSEVLEDAKF-EA--EQMGKSLTVSAPPGPwpINGNPNALASALE 359
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 379 NLLSNAIRYTpaGQAVTIQLSESAETIRLVVENPGTPIAAEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVSAHHG 458
Cdd:PRK09470 360 NIVRNALRYS--HTKIEVAFSVDKDGLTITVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRG 437
|
490
....*....|....*....
gi 751262903 459 SV-AVQSDRRSTRFIVVLP 476
Cdd:PRK09470 438 WVkAEDSPLGGLRLTIWLP 456
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
366-463 |
7.24e-24 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 95.94 E-value: 7.24e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 366 VTGDPLMLRRAISNLLSNAIRYTPAGQAVTIQLSESAETIrLVVENPGTPIAAEHLPRLFDRFYRVDPsrqRKGEGSGIG 445
Cdd:cd16940 7 VQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGAV-IRVEDNGPGIDEEELEALFERFYRSDG---QNYGGSGLG 82
|
90
....*....|....*...
gi 751262903 446 LAIVKSIVSAHHGSVAVQ 463
Cdd:cd16940 83 LSIVKRIVELHGGQIFLG 100
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
373-476 |
1.23e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 95.15 E-value: 1.23e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 373 LRRAISNLLSNAIRYTPAGQAVTIQLSESAETIRLVVENPGTPIAAEHLPRLFDRFYRVDPSrqRKGEGSGIGLAIVKSI 452
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNS--RNTEGAGLGLSIAKAI 78
|
90 100
....*....|....*....|....
gi 751262903 453 VSAHHGSVAVQSDRRSTRFIVVLP 476
Cdd:cd16923 79 IELHGGSASAEYDDNHDLFKVRLP 102
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
373-476 |
8.99e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 92.94 E-value: 8.99e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 373 LRRAISNLLSNAIRYTPAGQ-AVTIQL---SESAETIRLVVENPGTPIAAEHLPRLFDRFYRVDPSRQRKGEGSGIGLAI 448
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEGEvTLRVSLeeeEEDGVQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 751262903 449 VKSIVSAHHGSVAVQS-DRRSTRFIVVLP 476
Cdd:cd16922 81 SKKLVELMGGDISVESePGQGSTFTFTLP 109
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
261-476 |
1.24e-22 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 100.25 E-value: 1.24e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 261 NFSADIAHEIRTP---ITNLVTQTEIALSQSRSQQELEEVLYSnleEFSRMSRMVSDMLFLAQADNNQLipeqQALDLAD 337
Cdd:PRK10364 239 HLAAGVAHEIRNPlssIKGLAKYFAERAPAGGEAHQLAQVMAK---EADRLNRVVSELLELVKPTHLAL----QAVDLND 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 338 EVHKVFEFFEAWAEEKAVALRFVGSHC--RVTGDPLMLRRAISNLLSNAIRYTPAGQAVTIQLSESAETIRLVVENPGTP 415
Cdd:PRK10364 312 LINHSLQLVSQDANSREIQLRFTANDTlpEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKG 391
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 751262903 416 IAAEHLPRLFDRFYRVdpsrqrKGEGSGIGLAIVKSIVSAHHGSVAVQSDR-RSTRFIVVLP 476
Cdd:PRK10364 392 IAADQLEAIFTPYFTT------KAEGTGLGLAVVHNIVEQHGGTIQVASQEgKGATFTLWLP 447
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
266-476 |
1.50e-22 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 98.77 E-value: 1.50e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 266 IAHEIRTPITNLVTQTEIaLSQSRSQQELEEVLYSNLEEFSRMSRMVSDMLFLAQadnnQLIPEQQALDLADEVHKVFEF 345
Cdd:COG3852 142 LAHEIRNPLTGIRGAAQL-LERELPDDELREYTQLIIEEADRLNNLVDRLLSFSR----PRPPEREPVNLHEVLERVLEL 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 346 FEA-WAEEKAVALRFVGSHCRVTGDPLMLRRAISNLLSNAIRYTPAG----------QAVTIQLSESAETIRLVVENPGT 414
Cdd:COG3852 217 LRAeAPKNIRIVRDYDPSLPEVLGDPDQLIQVLLNLVRNAAEAMPEGgtitirtrveRQVTLGGLRPRLYVRIEVIDNGP 296
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 751262903 415 PIAAEHLPRLFDRFYRvdpsrqRKGEGSGIGLAIVKSIVSAHHGSVAVQS-DRRSTRFIVVLP 476
Cdd:COG3852 297 GIPEEILDRIFEPFFT------TKEKGTGLGLAIVQKIVEQHGGTIEVESePGKGTTFRIYLP 353
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
262-476 |
7.51e-22 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 96.78 E-value: 7.51e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 262 FSADIAHEIRTPITNLVTQTEIaLSQSRSQQELEEVLYSNLEEFSRMSRMVSDMLFLAQADNNQLipeqQALDLADEVHK 341
Cdd:COG5807 150 LAAGIAHEIRNPLTSIKGFLQL-LQESREDSEREEYFNIIISEIDRINTIITELLVLSKPKKFNF----KKLNLNDVLED 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 342 VFEFFEAWAEEKAVALR--FVGSHCRVTGDPLMLRRAISNLLSNAIRYTPAGQAVTIQLSESAETIRLVVENPGTPIAAE 419
Cdd:COG5807 225 VIALLSTEAILKNISIKydLADDEPVINGDKNQLKQVFINLIKNAIEAMETGGNITIKTYVEGDFVVISVKDEGIGIPEE 304
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 751262903 420 HLPRLFDRFYRVdpsrqrKGEGSGIGLAIVKSIVSAHHGSVAVQSD-RRSTRFIVVLP 476
Cdd:COG5807 305 VLEKIGEPFFTT------KEEGTGLGLSICKKIIEEHNGTIEVESKpGKGTTFTIYLP 356
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
369-463 |
3.35e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 85.59 E-value: 3.35e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 369 DPLMLRRAISNLLSNAIRYTPAGQAVTIQLSESAETIRLVVENPGTPIAAEHLPRLFDRFYRVD-PSRQRKgeGSGIGLA 447
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPrPHSGQK--STGLGLA 78
|
90
....*....|....*.
gi 751262903 448 IVKSIVSAHHGSVAVQ 463
Cdd:cd16945 79 FVQEVAQLHGGRITLR 94
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
373-477 |
5.02e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 85.07 E-value: 5.02e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 373 LRRAISNLLSNAIRYTPagQAVTIQLSESAETIRLVVENPGTPIAAEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSI 452
Cdd:cd16949 1 LARALENVLRNALRYSP--SKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERA 78
|
90 100
....*....|....*....|....*.
gi 751262903 453 VSAHHGSV-AVQSDRRSTRFIVVLPK 477
Cdd:cd16949 79 IEQHGGKIkASNRKPGGLRVRIWLPA 104
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
262-477 |
6.47e-20 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 92.34 E-value: 6.47e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 262 FSADIAHEIRTPITNLVTQTEIALSQSRSQQELeevlYSN--LEEFSRMSRMVSDMLFLA--QADNNQLIpeqqalDLAD 337
Cdd:COG5809 273 LAAGIAHEIRNPLTSLKGFIQLLKDTIDEEQKT----YLDimLSELDRIESIISEFLVLAkpQAIKYEPK------DLNT 342
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 338 EVHKVFEFFEAWAEEKAVALR--FVGSHCRVTGDPLMLRRAISNLLSNAIRYTPAGQAVTIQLSESAET-IRLVVENPGT 414
Cdd:COG5809 343 LIEEVIPLLQPQALLKNVQIEleLEDDIPDILGDENQLKQVFINLLKNAIEAMPEGGNITIETKAEDDDkVVISVTDEGC 422
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 751262903 415 PIAAEHLPRLFDRFYrvdpsrQRKGEGSGIGLAIVKSIVSAHHGSVAVQSDR-RSTRFIVVLPK 477
Cdd:COG5809 423 GIPEERLKKLGEPFY------TTKEKGTGLGLMVSYKIIEEHGGKITVESEVgKGTTFSITLPI 480
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
264-476 |
1.30e-19 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 91.57 E-value: 1.30e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 264 ADIAHEIRTPITNLVTQTEIaLSQSRSQQELEEVLYSNLEEFSRMSRMVSDMLFLAQADNNQLIPeqqaLDLADEVHKVF 343
Cdd:PRK11360 395 AGVAHEIRNPLTAIRGYVQI-WRQQTSDPPSQEYLSVVLREVDRLNKVIDQLLEFSRPRESQWQP----VSLNALVEEVL 469
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 344 EFFEAwaEEKAVALRFVGSHCR----VTGDPLMLRRAISNLLSNAIRYTPAGQAVTIQL-SESAETIRLVVENPGTPIAA 418
Cdd:PRK11360 470 QLFQT--AGVQARVDFETELDNelppIWADPELLKQVLLNILINAVQAISARGKIRIRTwQYSDGQVAVSIEDNGCGIDP 547
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 751262903 419 EHLPRLFDRFYRVDPSrqrkgeGSGIGLAIVKSIVSAHHGSVAVQSD-RRSTRFIVVLP 476
Cdd:PRK11360 548 ELLKKIFDPFFTTKAK------GTGLGLALSQRIINAHGGDIEVESEpGVGTTFTLYLP 600
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
164-476 |
1.65e-19 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 90.31 E-value: 1.65e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 164 LLMALSIDFHLHYINELKAKLISAATIISLLIIAIVLFVVYQghkpirqISRQIQNITSRDldvrldpqavpiELERLal 243
Cdd:COG5806 137 FLSALLLLLLAIIFIADISELLDFILYFIIIQLLAMLIAVYL-------IENLIENILLRK------------ELQRA-- 195
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 244 sfnhmlERIEDVftrqSNFSADIAHEIRTPITnlVTQ--TEIALSQSRSQQELEEVLYSNLEEFSRMSRMVSDMLFLAQA 321
Cdd:COG5806 196 ------EKLEVV----SELAASIAHEVRNPLT--VVRgfIQLLQEPELSDEKRKQYIRIALEELDRAEAIITDYLTFAKP 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 322 DNNQLipeqQALDLADEVHKVFEFFEAWAEEKAVALRfvgSHCR----VTGDPLMLRRAISNLLSNAIRYTPAGQAVTIQ 397
Cdd:COG5806 264 QPEKL----EKIDVSEELEHVIDVLSPYANMNNVEIQ---TELEpglyIEGDRQKLQQCLINIIKNGIEAMPNGGTLTID 336
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 398 LSESAETIRLVVENPGTPIAAEHLPRLFDRFYRVdpsrqrKGEGSGIGLAIVKSIVSAHHGSVAVQSD-RRSTRFIVVLP 476
Cdd:COG5806 337 VSIDKNKVIISIKDTGVGMTKEQLERLGEPYFST------KEKGTGLGTMVSYRIIEAMNGTIRVESEvGKGTTFTITLP 410
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
245-467 |
2.05e-19 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 90.35 E-value: 2.05e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 245 FNHMLERIEDVFTRQSNFSADIAHEIRTPITNLVTQTEIalsQSRSQQELEEVLYSNLEEfsrMSRMVSDmlFLAQADNN 324
Cdd:PRK09467 215 FNQMAAGIKQLEDDRTLLMAGVSHDLRTPLTRIRLATEM---MSEEDGYLAESINKDIEE---CNAIIEQ--FIDYLRTG 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 325 QLIPEQQAlDLADEVHKVfeffeAWAE---EKAVALRFVGSHCRVTGDPLMLRRAISNLLSNAIRYTpAGQaVTIQLSES 401
Cdd:PRK09467 287 QEMPMEMA-DLNALLGEV-----IAAEsgyEREIETALQPGPIEVPMNPIAIKRALANLVVNAARYG-NGW-IKVSSGTE 358
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 751262903 402 AETIRLVVENPGTPIAAEHLPRLFDRFYRVDpsRQRKGEGSGIGLAIVKSIVSAHHGSVAVQSDRR 467
Cdd:PRK09467 359 GKRAWFQVEDDGPGIPPEQLKHLFQPFTRGD--SARGSSGTGLGLAIVKRIVDQHNGKVELGNSEE 422
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
373-476 |
9.82e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 81.32 E-value: 9.82e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 373 LRRAISNLLSNAIRYtpAGQAVTIQLSESAETIRLVVENPGTPIAAEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSI 452
Cdd:cd16939 1 MARALDNLLRNALRY--AHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRV 78
|
90 100
....*....|....*....|....*
gi 751262903 453 VSAHHGSVAV-QSDRRSTRFIVVLP 476
Cdd:cd16939 79 ALWHGGHVECdDSELGGACFRLTWP 103
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
259-464 |
2.60e-18 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 88.30 E-value: 2.60e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 259 QSNFSADIAHEIRTPIT------NLVTQTEIALSQsrsQQELEEVLYSNleefSRMSRMVSDMLFLAQADNNQLIPEQQA 332
Cdd:TIGR02956 464 KSAFLATMSHEIRTPLNgilgtlELLGDTGLTSQQ---QQYLQVINRSG----ESLLDILNDILDYSKIEAGHLSISPRP 536
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 333 LDLADEVHKVFEFFEAWAEEKAVALRFVGS----HCRVtGDPLMLRRAISNLLSNAIRYTPAGQaVTIQLSESAE-TIRL 407
Cdd:TIGR02956 537 FDLNALLDDVHHLMVSRAQLKGIQLRLNIPeqlpNWWQ-GDGPRIRQVLINLVGNAIKFTDRGS-VVLRVSLNDDsSLLF 614
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 751262903 408 VVENPGTPIAAEHLPRLFDRFYRVDpSRQRKGeGSGIGLAIVKSIVSAHHGSVAVQS 464
Cdd:TIGR02956 615 EVEDTGCGIAEEEQATLFDAFTQAD-GRRRSG-GTGLGLAISQRLVEAMDGELGVES 669
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
189-476 |
2.12e-17 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 85.46 E-value: 2.12e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 189 TIISLLIIAIVLFVVYQghkpiRQISRQIQNITSR-------DLDVRLdPQAVPIELERLALSFNHML------------ 249
Cdd:PRK15347 302 ALLILVLLTSVLFLLLR-----RYLAKPLWRFVDIinktgpaALEPRL-PENRLDELGSIAKAYNQLLdtlneqydtlen 375
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 250 ---ERI----------EDVFTRQSNFSADIAHEIRTPIT------NLVTQTEIALSQsrsQQELEEVLYS---------N 301
Cdd:PRK15347 376 kvaERTqalaeakqraEQANKRKSEHLTTISHEIRTPLNgvlgalELLQNTPLTAEQ---MDLADTARQCtlsllaiinN 452
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 302 LEEFSRMsrmvsdmlflaQADNNQLIPEQQA-LDLADEVHKVFEffeAWAEEKAVALR-FVGSHCRVTG--DPLMLRRAI 377
Cdd:PRK15347 453 LLDFSRI-----------ESGQMTLSLEETAlLPLLDQAMLTIQ---GPAQSKSLTLRtFVGAHVPLYLhlDSLRLRQIL 518
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 378 SNLLSNAIRYTPAGQavtIQLSESAETIRLV--VENPGTPIAAEHLPRLFDRFYRVDPSRQrkgeGSGIGLAIVKSIVSA 455
Cdd:PRK15347 519 VNLLGNAVKFTETGG---IRLRVKRHEQQLCftVEDTGCGIDIQQQQQIFTPFYQADTHSQ----GTGLGLTIASSLAKM 591
|
330 340
....*....|....*....|..
gi 751262903 456 HHGSVAVQSD-RRSTRFIVVLP 476
Cdd:PRK15347 592 MGGELTLFSTpGVGSCFSLVLP 613
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
263-477 |
3.07e-17 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 84.01 E-value: 3.07e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 263 SADIAHEIRTPITNLvtQTEIALSQSrSQQELEEVLYSNLEEFSRMSRMVSDMLFLAQADNNQLipeqQALDLADEVHKV 342
Cdd:COG5805 291 AAGIAHEIRNPLTSI--KGFLQLLQP-GIEDKEEYFDIMLSELDRIESIISEFLALAKPQAVNK----EKENINELIQDV 363
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 343 FEFFEAWAEEKAVALRFVGSH--CRVTGDPLMLRRAISNLLSNAIRYTPAGQAVTIQLSESAETIRLVVENPGTPIAAEH 420
Cdd:COG5805 364 VTLLETEAILHNIQIRLELLDedPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEER 443
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 751262903 421 LPRLFDRFYRVdpsrqrKGEGSGIGLAIVKSIVSAHHGSVAVQSDR-RSTRFIVVLPK 477
Cdd:COG5805 444 LKKLGEPFFTT------KEKGTGLGLMVSYKIIENHNGTIDIDSKVgKGTTFTITLPL 495
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
370-476 |
3.87e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 76.69 E-value: 3.87e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 370 PLMLRRAISNLLSNAIRYTPAGQAVTIQLSESAETIRLVVENPGTPIAAEHLPRLFDRFYRVDPSrqrkGEGSGIGLAIV 449
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPV----GEGTGLGLSLS 76
|
90 100
....*....|....*....|....*...
gi 751262903 450 KSIVSAHHGSVAVQSDR-RSTRFIVVLP 476
Cdd:cd16943 77 YRIIQKHGGTIRVASVPgGGTRFTIILP 104
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
350-477 |
4.02e-17 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 82.97 E-value: 4.02e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 350 AEEKAVALRfVGSHCRVTGDPL---MLRRAISNLLSNAIRYTPAGQA----VTIQLSESAETIRLVVENPGTPIAAEHLP 422
Cdd:COG3290 257 ARERGIDLT-IDIDSDLPDLPLsdtDLVTILGNLLDNAIEAVEKLPEeerrVELSIRDDGDELVIEVEDSGPGIPEELLE 335
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 751262903 423 RLFDRFYrvdPSRqrKGEGSGIGLAIVKSIVSAHHGSVAVQS-DRRSTRFIVVLPK 477
Cdd:COG3290 336 KIFERGF---STK--LGEGRGLGLALVKQIVEKYGGTIEVESeEGEGTVFTVRLPK 386
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
373-475 |
5.90e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 76.78 E-value: 5.90e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 373 LRRAISNLLSNAIRYTPAGQAVTIQLSESAETIRLVVENPGTPIAAEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSI 452
Cdd:cd16947 21 LQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQGNGLGLTITKRL 100
|
90 100
....*....|....*....|....
gi 751262903 453 VSAHHGSVAVQSD-RRSTRFIVVL 475
Cdd:cd16947 101 AESMGGSIYVNSKpYEKTVFTVTL 124
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
259-476 |
1.02e-16 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 83.25 E-value: 1.02e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 259 QSNFSADIAHEIRTPITNLVTQTEIALSQSRSQQELEEVLYSNLEEFSRMSRMVSDMLFLAQADNNQLIPEQQALDLADE 338
Cdd:PRK09959 712 KSQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIESGNYQLQPQWVDIPTL 791
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 339 VHKVFEFFEAWAEEKAVALRFVGS---HCRVTGDPLMLRRAISNLLSNAIRYTPAGqAVTIQLS-----ESAETIRLVVE 410
Cdd:PRK09959 792 VQNTCHSFGAIAASKSIALSCSSTfpdHYLVKIDPQAFKQVLSNLLSNALKFTTEG-AVKITTSlghidDNHAVIKMTIM 870
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 751262903 411 NPGTPIAAEHLPRLFDRFYRVDPSRQRKGegSGIGLAIVKSIVSAHHGSVAVQSDRR-STRFIVVLP 476
Cdd:PRK09959 871 DSGSGLSQEEQQQLFKRYSQTSAGRQQTG--SGLGLMICKELIKNMQGDLSLESHPGiGTTFTITIP 935
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
369-462 |
1.26e-16 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 75.61 E-value: 1.26e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 369 DPLMLRRAISNLLSNAIRYTPAGQAVTIQLSES-AETIRLVVENPGTPIAAEHLPRLFDRFYRVDPSRQRKGEGSGIGLA 447
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKFrLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLS 80
|
90
....*....|....*
gi 751262903 448 IVKSIVSAHHGSVAV 462
Cdd:cd16925 81 IVKEFVELHGGTVTV 95
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
373-460 |
1.91e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 74.79 E-value: 1.91e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 373 LRRAISNLLSNAIRYtpAGQAVTIQLSESAETIRLVVENPGTPIAAEHLPRLFDRFYRVDPSrqRKGEGSGIGLAIVKSI 452
Cdd:cd16950 1 LKRVLSNLVDNALRY--GGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNA--RGTSGTGLGLAIVQRI 76
|
....*...
gi 751262903 453 VSAHHGSV 460
Cdd:cd16950 77 SDAHGGSL 84
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
238-476 |
3.46e-16 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 81.62 E-value: 3.46e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 238 LERLALSFNHMLERI--EDVFTRQSNFSAdIAHEIRTPITNLVTQTEI-----ALSQSRSQQELEEVLYSNLEefsrMSR 310
Cdd:PRK10490 642 LERLTLTASEEQARLasEREQLRNALLAA-LSHDLRTPLTVLFGQAEIltldlASEGSPHARQASEIRQQVLN----TTR 716
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 311 MVSDMLFLA--QADNNQLIPEQQALDlaDEVHKVFEFFEAWAEEKAVALRFVGSHCRVTGDPLMLRRAISNLLSNAIRYT 388
Cdd:PRK10490 717 LVNNLLDMAriQSGGFNLRKEWLTLE--EVVGSALQMLEPGLSGHPINLSLPEPLTLIHVDGPLFERVLINLLENAVKYA 794
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 389 PAGQAVTIQLSESAETIRLVVENPGTPIAAEHLPRLFDRFYRVDpsRQRKGEGSGIGLAIVKSIVSAHHGSV-AVQSDRR 467
Cdd:PRK10490 795 GAQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGN--KESAIPGVGLGLAICRAIVEVHGGTIwAENRPEG 872
|
....*....
gi 751262903 468 STRFIVVLP 476
Cdd:PRK10490 873 GACFRVTLP 881
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
369-463 |
3.91e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 74.04 E-value: 3.91e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 369 DPLMLRRAISNLLSNAIRYTPAGQAVTIQLSESAETIRLVVENPGTPIAAEHLPRLFDRFYRVDPSRQRKGEgSGIGLAI 448
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGH-YGMGLYI 79
|
90
....*....|....*
gi 751262903 449 VKSIVSAHHGSVAVQ 463
Cdd:cd16975 80 AKNLVEKHGGSLIIE 94
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
373-476 |
4.27e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 73.90 E-value: 4.27e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 373 LRRAISNLLSNAIRYTPAGQ--AVTIQLSESAETIRLVVENPGTPIAAEHLPRLFDRFYRVDPsrQRKGEGSGIGLAIVK 450
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRppRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHS--REEYEGTGVGLAIVR 78
|
90 100
....*....|....*....|....*..
gi 751262903 451 SIVSAHHGSVAVQSDR-RSTRFIVVLP 476
Cdd:cd16921 79 KIIERHGGRIWLESEPgEGTTFYFTLP 105
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
266-465 |
3.06e-15 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 77.30 E-value: 3.06e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 266 IAHEIRTPIT--NLVTQTeIALSQSRSQQELEEVLYSNLEEFSR-----MSRMVSDMLFLAQADNNQLIPEQQALDLADE 338
Cdd:PRK09303 158 LAHDLRTPLTaaSLALET-LELGQIDEDTELKPALIEQLQDQARrqleeIERLITDLLEVGRTRWEALRFNPQKLDLGSL 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 339 VHKVFEFFEAWAEEKAVALR--FVGSHCRVTGDPLMLRRAISNLLSNAIRYTPAGQAVTIQ-LSESAETIRLVVENPGTP 415
Cdd:PRK09303 237 CQEVILELEKRWLAKSLEIQtdIPSDLPSVYADQERIRQVLLNLLDNAIKYTPEGGTITLSmLHRTTQKVQVSICDTGPG 316
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 751262903 416 IAAEHLPRLFDRFYRVDPSRQRkgEGSGIGLAIVKSIVSAHHGSVAVQSD 465
Cdd:PRK09303 317 IPEEEQERIFEDRVRLPRDEGT--EGYGIGLSVCRRIVRVHYGQIWVDSE 364
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
373-476 |
6.46e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 67.98 E-value: 6.46e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 373 LRRAISNLLSNAIRYTPAGQA-VTIQLSESAETIRLVVENPGTPIAAEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKS 451
Cdd:cd16953 1 LGQVLRNLIGNAISFSPPDTGrITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQHSGLGLSISRQ 80
|
90 100 110
....*....|....*....|....*....|
gi 751262903 452 IVSAHHGSVAVQSDR-----RSTRFIVVLP 476
Cdd:cd16953 81 IIEAHGGISVAENHNqpgqvIGARFTVQLP 110
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
368-476 |
1.77e-13 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 73.08 E-value: 1.77e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 368 GDPLMLRRAISNLLSNAIRYTPAGqAVTIQLSESAETIRLVVENPGTPIAAEHLPRLFDRFYRVDPSRQRKGEGSGIGLA 447
Cdd:PRK10841 558 GDPMRLQQVISNLLSNAIKFTDTG-CIVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLA 636
|
90 100 110
....*....|....*....|....*....|
gi 751262903 448 IVKSIVSAHHGSVAVQSDRR-STRFIVVLP 476
Cdd:PRK10841 637 ICEKLINMMDGDISVDSEPGmGSQFTIRIP 666
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
373-476 |
2.67e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 66.15 E-value: 2.67e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 373 LRRAISNLLSNAIRYTPAGQAVTIQLSESAETIRLVVENPGTPIAAEHLPRLFDRFYRVDPSRQRKgEGSGIGLAIVKSI 452
Cdd:cd16948 6 LSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQ-ESTGMGLYLVKKL 84
|
90 100
....*....|....*....|....*
gi 751262903 453 VSAHHGSVAVQSDRRS-TRFIVVLP 476
Cdd:cd16948 85 CDKLGHKIDVESEVGEgTTFTITFP 109
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
227-476 |
7.57e-12 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 67.78 E-value: 7.57e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 227 VRLDPQAVPIElERLALSfnhmlERIEDVFTrqsnFSADIAHEIRTPITNLVTQTEIALSQSRSQQELEEVLYSNLEEFS 306
Cdd:PRK13837 428 RRLETERDALE-RRLEHA-----RRLEAVGT----LASGIAHNFNNILGAILGYAEMALNKLARHSRAARYIDEIISAGA 497
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 307 RMSRMVSDMLFLAQADNNQLIPeqqaLDLADEVHKVFEFFEA-WAEEKAVALRFVGSHCRVTGDPLMLRRAISNLLSNAI 385
Cdd:PRK13837 498 RARLIIDQILAFGRKGERNTKP----FDLSELVTEIAPLLRVsLPPGVELDFDQDQEPAVVEGNPAELQQVLMNLCSNAA 573
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 386 RYTPAGQAVTIQLSESA---------------ETIRLVVENPGTPIAAEHLPRLFDRFYRVdpsrqRKGeGSGIGLAIVK 450
Cdd:PRK13837 574 QAMDGAGRVDISLSRAKlrapkvlshgvlppgRYVLLRVSDTGAGIDEAVLPHIFEPFFTT-----RAG-GTGLGLATVH 647
|
250 260
....*....|....*....|....*..
gi 751262903 451 SIVSAHHGSVAVQSD-RRSTRFIVVLP 476
Cdd:PRK13837 648 GIVSAHAGYIDVQSTvGRGTRFDVYLP 674
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
262-476 |
1.64e-11 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 66.50 E-value: 1.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 262 FSADIAHEIRTPITNLVTQTEIALsqsrsQQELeevlysNLEEFSRMSRM-VS---------DMLFLAQADNNQLIPEQQ 331
Cdd:PRK11091 286 FISTISHELRTPLNGIVGLSRILL-----DTEL------TAEQRKYLKTIhVSaitlgnifnDIIDMDKMERRKLQLDNQ 354
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 332 ALDLADEVHKVFEFFEAWAEEKAvaLRFVGS------HcRVTGDPLMLRRAISNLLSNAIRYTPAGQAVTIQLSESAETI 405
Cdd:PRK11091 355 PIDFTDFLADLENLSGLQAEQKG--LRFDLEpllplpH-KVITDGTRLRQILWNLISNAVKFTQQGGVTVRVRYEEGDML 431
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 751262903 406 RLVVENPGTPIAAEHLPRLFDRFYRV-DPSRQRKGEGSGIGLAIVKSIVSAHHGSVAVQSDR-RSTRFIVVLP 476
Cdd:PRK11091 432 TFEVEDSGIGIPEDELDKIFAMYYQVkDSHGGKPATGTGIGLAVSKRLAQAMGGDITVTSEEgKGSCFTLTIH 504
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
162-477 |
1.69e-11 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 65.81 E-value: 1.69e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 162 YHLLMALSIDFHLHYINELKAKLISAATIISLLIIAIVLFVVYQGHKPIRQISRQIQNITSRDLdVRLDPQAvPIELERL 241
Cdd:COG2972 137 WTLVSLIPKSELFRGLFSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDL-VRLEVSG-NDEIGIL 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 242 ALSFNHMLERIEDVFTRQSNFSADIAH-EIRtpitNLVTQ-----------TEIALSQSRSQQELEEVLYSnleeFSRMS 309
Cdd:COG2972 215 ARSFNEMVERIKELIEEVYELELEKKEaELK----ALQAQinphflfntlnSIRWLAELEDPEEAEEMLEA----LSKLL 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 310 RMVSDmlflaqaDNNQLIPEQQALDLAD---EVHKV-----FEFFEAWAEEkavalrfvgshcrvTGDPLMLRRAISNLL 381
Cdd:COG2972 287 RYSLS-------KGDELVTLEEELELIKsylEIQKLrfgdrLEVEIEIDEE--------------LLDLLIPKLILQPLV 345
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 382 SNAIRY----TPAGQAVTIQLSESAETIRLVVENPGTPIAAEHLPRLFDRFyrvdpsrQRKGEGSGIGLAIVKSIVSAHH 457
Cdd:COG2972 346 ENAIEHgiepKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL-------SSKGEGRGIGLRNVRERLKLYY 418
|
330 340
....*....|....*....|....
gi 751262903 458 GSVAV----QSDRRSTRFIVVLPK 477
Cdd:COG2972 419 GEEYGleieSEPGEGTTVTIRIPL 442
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
373-476 |
5.52e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 59.33 E-value: 5.52e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 373 LRRAISNLLSNAIR----YTPAGQAVTIQLSESAE-TIRLVVENPGTPIAAEHLPRLFDRFYRVdpsrqrKGEGSGIGLA 447
Cdd:cd16920 1 IQQVLINLVRNGIEamseGGCERRELTIRTSPADDrAVTISVKDTGPGIAEEVAGQLFDPFYTT------KSEGLGMGLS 74
|
90 100 110
....*....|....*....|....*....|
gi 751262903 448 IVKSIVSAHHGSV-AVQSDRRSTRFIVVLP 476
Cdd:cd16920 75 ICRSIIEAHGGRLsVESPAGGGATFQFTLP 104
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
258-320 |
1.43e-10 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 56.84 E-value: 1.43e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 751262903 258 RQSNFSADIAHEIRTPITNLVTQTEIALSQSRSQQELEEVLYSNLEEFSRMSRMVSDMLFLAQ 320
Cdd:cd00082 3 AKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
258-324 |
2.70e-10 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 56.07 E-value: 2.70e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 751262903 258 RQSNFSADIAHEIRTPITNLVTQTEIaLSQSRSQQELEEVLYSNLEEFSRMSRMVSDMLFLAQADNN 324
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLEL-LRDEKLDEEQREYLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
379-475 |
2.70e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 55.33 E-value: 2.70e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 379 NLLSNAIRYtpAGQAVTIQLSESAETIRLVVENPGTPIAAEHLPRLFDRFYRVDPSRQrkgeGSGIGLAIVKSIVSAHHG 458
Cdd:cd16954 44 NLLDNACKW--CLEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDEQRP----GQGLGLAIAKEIVEQYGG 117
|
90
....*....|....*...
gi 751262903 459 SVAVQSDRRS-TRFIVVL 475
Cdd:cd16954 118 ELSLSDSPLGgARFEVVF 135
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
258-324 |
4.52e-09 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 52.57 E-value: 4.52e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 751262903 258 RQSNFSADIAHEIRTPITNLVTQTEIALSQSRSQQElEEVLYSNLEEFSRMSRMVSDMLFLAQADNN 324
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQ-REYLETILREAERLLRLINDLLDLSRIEAG 66
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
193-462 |
1.06e-08 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 57.34 E-value: 1.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 193 LLIIAIVLFVVYQGHKPIRQISRQIQNIT--SRDldvRLDPQAvPIELERLALSFNHMLERIEDVFTRQSNFSADIAHEI 270
Cdd:PRK10815 202 LLVIPLLWLAAWWSLRPIEALAKQVRELEegERE---QLDPNP-PRELTSLVRNLNRLLKNERERYTKYRTTLTDLTHSL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 271 RTPITnlVTQTeiALSQSRSQQEL--EEVLYSNLEEFSRMSRMVSDMLFLA--QADNNQLIPEQQA----LD-LADEVHK 341
Cdd:PRK10815 278 KTPLA--VLQS--TLRSLRSGKQMsvEQAEPIMLEQISRISQQIGYYLHRAsmRSEHNLLSRELHSvaplLDnLTSALNK 353
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 342 VFEffeawaeEKAVALR--------FVGSH---CRVTGdplmlrraisNLLSNAIRYTPagQAVTIQLSESAETIRLVVE 410
Cdd:PRK10815 354 VYQ-------RKGVNITldispeitFVGEKndfMEVMG----------NVLDNACKYCL--EFVEISARQTDEHLHIVVE 414
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 751262903 411 N--PGTPIAAEHLprLFDRFYRVDPSRqrkgEGSGIGLAIVKSIVSAHHGSVAV 462
Cdd:PRK10815 415 DdgPGIPESKREL--IFDRGQRADTLR----PGQGLGLSVAREITEQYEGKISA 462
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
379-464 |
1.39e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 52.46 E-value: 1.39e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 379 NLLSNAirYTPAGQ----AVTIQLSESAETIRLVVENPGTPIAAEHLPRLFDRFYRVDPSrqrkGEGSGIGLAIVKSIVS 454
Cdd:cd16976 7 NLLQNA--LDAMGKvenpRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPV----GKGTGLGLSISYGIVE 80
|
90
....*....|
gi 751262903 455 AHHGSVAVQS 464
Cdd:cd16976 81 EHGGRLSVAN 90
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
366-475 |
2.05e-08 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 56.78 E-value: 2.05e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 366 VTGDPLMLRRAISNLLSNAIRYTPAGQ-AVTIQLSESAE---TIRLVVENPGTPIAAEHLPRLFDRFYRVDPSRQRKGEG 441
Cdd:PRK11107 402 VIGDPLRLQQIITNLVGNAIKFTESGNiDILVELRALSNtkvQLEVQIRDTGIGISERQQSQLFQAFRQADASISRRHGG 481
|
90 100 110
....*....|....*....|....*....|....*..
gi 751262903 442 SGIGLAIVKSIVSAHHGSVAVQS--DRRST-RFIVVL 475
Cdd:PRK11107 482 TGLGLVITQKLVNEMGGDISFHSqpNRGSTfWFHLPL 518
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
208-252 |
3.76e-08 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 49.37 E-value: 3.76e-08
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 751262903 208 KPIRQISRQIQNITSRDLDVRLDPQAvPIELERLALSFNHMLERI 252
Cdd:cd06225 2 RPLRRLTEAARRIAEGDLDVRVPVRS-KDEIGELARAFNQMAERL 45
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
208-254 |
5.61e-08 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 49.17 E-value: 5.61e-08
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 751262903 208 KPIRQISRQIQNITSRDLDVRLDPQAVPiELERLALSFNHMLERIED 254
Cdd:smart00304 5 RPLRRLAEAAQRIADGDLTVRLPVDGRD-EIGELARAFNEMADRLEE 50
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
373-476 |
9.33e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 50.09 E-value: 9.33e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 373 LRRAISNLLSNAIRYTPAGQ-----------AVTIQLSESAETIRLVVENPGTPIAAEHLPRLFDrfyrvdPSRQRKGEG 441
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGSGgeiilrtrtqrQVTLGHPRHRLALRVSVIDNGPGIPPDLQDTIFY------PMVSGRENG 74
|
90 100 110
....*....|....*....|....*....|....*
gi 751262903 442 SGIGLAIVKSIVSAHHGSVAVQSDRRSTRFIVVLP 476
Cdd:cd16918 75 TGLGLAIAQNIVSQHGGVIECDSQPGHTVFSVSLP 109
|
|
| HAMP |
pfam00672 |
HAMP domain; |
201-254 |
1.31e-07 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 48.00 E-value: 1.31e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 751262903 201 FVVYQGHKPIRQISRQIQNITSRDLDVRLDPQAvPIELERLALSFNHMLERIED 254
Cdd:pfam00672 1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSG-RDEIGELARAFNQMAERLRE 53
|
|
| HATPase_c_5 |
pfam14501 |
GHKL domain; This family represents the structurally related ATPase domains of histidine ... |
369-465 |
3.88e-07 |
|
GHKL domain; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 433996 [Multi-domain] Cd Length: 102 Bit Score: 48.37 E-value: 3.88e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 369 DPLMLRRAISNLLSNAI---RYTPAGQAVTIQLSESAETIRLVVENPgtpiaAEHLPRLFDRFyrvdPSRQRKGEGSGIG 445
Cdd:pfam14501 2 SDVDLCVIFGNLLDNAIeacSKIDDNRFIRLKIREKQNFLIIRIENT-----YEGELKFEGKL----PSTKTKGDGHGIG 72
|
90 100
....*....|....*....|
gi 751262903 446 LAIVKSIVSAHHGSVAVQSD 465
Cdd:pfam14501 73 LKSIRRIVKKYGGNLSTEIE 92
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
232-476 |
8.94e-07 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 51.44 E-value: 8.94e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 232 QAVPIELERLALSFNHMLERIEDVFTRQSNFSADIAHEIRTPITNLVTQTEI-----ALSQSR--------SQQELEEVL 298
Cdd:PRK11466 417 KARTAELQELVIEHRQARAEAEKASQAKSAFLAAMSHEIRTPLYGILGTAQLladnpALNAQRddlraitdSGESLLTIL 496
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 299 -----YSNLEEFSRmSRMVSDMLFlaqaDNNQLIpeQQALDLADEvhKVFEFFEAWAEEKAVALRfvgshCRVTGDPLML 373
Cdd:PRK11466 497 ndildYSAIEAGGK-NVSVSDEPF----EPRPLL--ESTLQLMSG--RVKGRPIRLATDIADDLP-----TALMGDPRRI 562
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 374 RRAISNLLSNAIRYTPAGqAVTIQLSESAETIRLVVENPGTPIAAEHLPRLFDRFYRVDPSRQrkgeGSGIGLAIVKSIV 453
Cdd:PRK11466 563 RQVITNLLSNALRFTDEG-SIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKRG----GTGLGLTISSRLA 637
|
250 260
....*....|....*....|....
gi 751262903 454 SAHHGSVAVQSD-RRSTRFIVVLP 476
Cdd:PRK11466 638 QAMGGELSATSTpEVGSCFCLRLP 661
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
179-314 |
1.29e-06 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 50.79 E-value: 1.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 179 ELKAKLISAATIISLLIIAIVLFVVYQGHKPIRQISRQIQNITSRDLDVRLDPQAVPiELERLALSFNHMLERIEDVFTR 258
Cdd:COG0840 179 LALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKD-EIGQLADAFNRMIENLRELVGQ 257
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 751262903 259 QSNFS---ADIAHEIRTPITNLVTQTEialsqsRSQQELEEVLySNLEEFSRMSRMVSD 314
Cdd:COG0840 258 VRESAeqvASASEELAASAEELAAGAE------EQAASLEETA-AAMEELSATVQEVAE 309
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
369-476 |
2.97e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 45.99 E-value: 2.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 369 DPLMLRRAISNLLSNAI-----RYTPAGQaVTIQLSESAET-IRLVVENPGTPIAAEHLPRLFDrfyrvdPSRQRKGEGS 442
Cdd:cd16944 1 DTTQISQVLTNILKNAAeaiegRPSDVGE-VRIRVEADQDGrIVLIVCDNGKGFPREMRHRATE------PYVTTRPKGT 73
|
90 100 110
....*....|....*....|....*....|....*
gi 751262903 443 GIGLAIVKSIVSAHHGSVAVQS-DRRSTRFIVVLP 476
Cdd:cd16944 74 GLGLAIVKKIMEEHGGRISLSNrEAGGACIRIILP 108
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
266-464 |
5.51e-06 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 48.91 E-value: 5.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 266 IAHEIRTPITNLVT---QTEIALSQSRSQQELEEVLY-SNLEEfsRMSRMVSDMLFLAQADNNQLipeqQALDLADEVHK 341
Cdd:COG4192 440 LAHELNQPLNAMSMylfSAKKALEQENYAQLPTSLDKiEGLIE--RMDKIIKSLRQFSRKSDTPL----QPVDLRQVIEQ 513
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 342 VFEFFEAWAEEKAVALRFVGSHcRVTGDPLMLRRAISNLLSNAIRYTPAGQAVTIQLSESAETIRLVVENPGT--PIAae 419
Cdd:COG4192 514 AWELVESRAKPQQITLHIPDDL-MVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNgwPLV-- 590
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 751262903 420 hlPRLFDRFYrvdpsrQRKGEGSGIGLAIVKSIVSAHHGSVAVQS 464
Cdd:COG4192 591 --DKLFTPFT------TTKEVGLGLGLSICRSIMQQFGGDLYLAS 627
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
354-476 |
1.96e-05 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 44.13 E-value: 1.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 354 AVALRFVGSHCRVTGDPLMLRR----AISNLLSNAIRYTPAGQA---VTIQLSESAETIRLVVENPGTPIAAEHLPrlfd 426
Cdd:COG2172 12 GLARRAVRALLRELGLDEDDADdlvlAVSEAVTNAVRHAYGGDPdgpVEVELELDPDGLEIEVRDEGPGFDPEDLP---- 87
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 751262903 427 rfyrvDPSRQRKgeGSGIGLAIVKSIVSahhgSVAVQSDRRSTRFIVVLP 476
Cdd:COG2172 88 -----DPYSTLA--EGGRGLFLIRRLMD----EVEYESDPGGTTVRLVKR 126
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
328-476 |
2.11e-05 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 45.76 E-value: 2.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 328 PEQQALDLADEVHKVFEFFEAwAEEKAVALRFVGSHCRVTGDP-LMLRRAISNLLSNAIRYTPAGQaVTIQLSESAETIR 406
Cdd:COG4585 118 PALDDLGLAAALEELAERLLR-AAGIRVELDVDGDPDRLPPEVeLALYRIVQEALTNALKHAGATR-VTVTLEVDDGELT 195
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 751262903 407 LVVENPGTPIAAEHLPrlfdrfyrvdpsrqrkgeGSGIGLAIVKSIVSAHHGSVAVQSDRRS-TRFIVVLP 476
Cdd:COG4585 196 LTVRDDGVGFDPEAAP------------------GGGLGLRGMRERAEALGGTLTIGSAPGGgTRVRATLP 248
|
|
| PRK10935 |
PRK10935 |
nitrate/nitrite two-component system sensor histidine kinase NarQ; |
170-248 |
7.08e-05 |
|
nitrate/nitrite two-component system sensor histidine kinase NarQ;
Pssm-ID: 236800 [Multi-domain] Cd Length: 565 Bit Score: 45.23 E-value: 7.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 170 ID---FHLHYINELKAKLISAATIISL-LIIAIVLFVVY----QGHKPIRQI---SRQIQNitsRDLD-VRLDPQAvPIE 237
Cdd:PRK10935 132 IDlfvLALQHFAERKLILLAAISLLGLiLILTLVFFTVRftrrQVVAPLNQLvtaSQQIEK---GQFDhIPLDTTL-PNE 207
|
90
....*....|.
gi 751262903 238 LERLALSFNHM 248
Cdd:PRK10935 208 LGLLAKAFNQM 218
|
|
| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
376-453 |
8.22e-04 |
|
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 38.40 E-value: 8.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 376 AISNLLSNAIRYTPA---GQAVTIQLSESAETIRLVVENPGTPiaaehlprlFDRFYRVDPSRQRKgeGSGIGLAIVKSI 452
Cdd:cd16936 4 AVSEAVTNAVRHAYRhdgPGPVRLELDLDPDRLRVEVTDSGPG---------FDPLRPADPDAGLR--EGGRGLALIRAL 72
|
.
gi 751262903 453 V 453
Cdd:cd16936 73 M 73
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
331-476 |
1.45e-03 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 41.04 E-value: 1.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 331 QALDLADEVHKVFEFFEAWAEEKAVALRFVGSHCRVTGD---PLMLrrAISNLLSNAIRY----TPAGQaVTIQLSESAE 403
Cdd:COG3920 357 EGVDLRDYLRELLEPLRDSYGGRGIRIELDGPDVELPADaavPLGL--ILNELVTNALKHaflsGEGGR-IRVSWRREDG 433
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 751262903 404 TIRLVVENPGTPIaaehlprlfdrfyrvdPSRQRKGEGSGIGLAIVKSIVSAHHGSVAVQSDRRsTRFIVVLP 476
Cdd:COG3920 434 RLRLTVSDNGVGL----------------PEDVDPPARKGLGLRLIRALVRQLGGTLELDRPEG-TRVRITFP 489
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
160-475 |
1.51e-03 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 41.02 E-value: 1.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 160 PAYHLLMALSIDFHLHYINELKAKLISAATIISLLIIAIVLFVVYQG-HKPIRQISRQIQNITSRDLDVRLDPQAVPiEL 238
Cdd:COG3850 95 LLLLLLLLLLLLLLLLLAAAINRKLALLRLLLALLLALLLAYLLRRRiVRPLRRLTQAAERIARGDFDARVPVSGRD-EL 173
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 239 ERLALSFNHMLERIEDVF------TRQSNFSADIAHEIRTPITNLVTQTEIALSQSRSQQELEEVLYSNLEEFSRMSRMV 312
Cdd:COG3850 174 GTLARAFNRMADELQELYaeleeeEELEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAESEL 253
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 313 SDMLFLAQADNNQLIPEQQALDLADEVHKVFEFFEAWAEEKAVALRFVGSHCRVTGDPLMLRRAISNLLSNAIRYTPAGQ 392
Cdd:COG3850 254 LALNILAGLLELLLALLLLLLASALLLLELELLALLLELVELLALAAAEEALLLLVELAALLLLLLLQAIANASLLLIAL 333
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 393 AVTIQLSESAETIRLVVENPGTPIAAEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVSAHHGSVAVQSDRRSTRFI 472
Cdd:COG3850 334 ASVVAALLELASILALQAALEAAAAGAALAAAAAAAGLARALAQAGADAAEALGLLAEASEGAAGQGAGLVDVEGGVAGE 413
|
...
gi 751262903 473 VVL 475
Cdd:COG3850 414 GGL 416
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
373-476 |
2.58e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 37.74 E-value: 2.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 373 LRRAISNLLSNAIRYTPAGQAVTIQLSE---------------SAETIRLVVENPGTPIAAEHLPRLFDRFYRVDPSrqr 437
Cdd:cd16919 1 LELAILNLAVNARDAMPEGGRLTIETSNqrvdadyalnyrdliPGNYVCLEVSDTGSGMPAEVLRRAFEPFFTTKEV--- 77
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 751262903 438 kGEGSGIGLAIVKSIVSAHHGSVAVQSDR-RSTRFIVVLP 476
Cdd:cd16919 78 -GKGTGLGLSMVYGFVKQSGGHLRIYSEPgVGTTVRIYLP 116
|
|
| HATPase_AgrC-ComD-like |
cd16935 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
369-475 |
2.82e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.
Pssm-ID: 340412 [Multi-domain] Cd Length: 134 Bit Score: 37.94 E-value: 2.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 369 DPLMLRRAISNLLSNAI---RYTPAGQA---VTIQLSESAETIRlvVENPgtpiAAEHLPRLFDRFYRvdpsrQRKGEGS 442
Cdd:cd16935 33 SPLDLCIIFGNLLDNAIeacAKIDKENRfihLKIRQKKGFLIIS--IENS----YEGELKKKNGLFLS-----TKKDKNH 101
|
90 100 110
....*....|....*....|....*....|...
gi 751262903 443 GIGLAIVKSIVSAHHGSVAVQSDRRSTRFIVVL 475
Cdd:cd16935 102 GIGLKSIREIVKKYNGNLSIEYENGIFTLSILL 134
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
364-464 |
4.81e-03 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 39.27 E-value: 4.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 364 CRVtgDPLMLRRAISNLLSNAIRYTPAGQAVTIQ----LSESAETI--------RLV---VENPGTPIAAEHLPRLFDRF 428
Cdd:PRK13557 271 CRI--DPTQAEVALLNVLINARDAMPEGGRVTIRtrnvEIEDEDLAmyhglppgRYVsiaVTDTGSGMPPEILARVMDPF 348
|
90 100 110
....*....|....*....|....*....|....*.
gi 751262903 429 YrvdpSRQRKGEGSGIGLAIVKSIVSAHHGSVAVQS 464
Cdd:PRK13557 349 F----TTKEEGKGTGLGLSMVYGFAKQSGGAVRIYS 380
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
184-448 |
6.20e-03 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 39.33 E-value: 6.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 184 LISAATIISLLIIAIVLFVVYQGHKPIRQISRQIQNITSRDLDVRLDPQAVPiELERLALSFNHMLERIEDVFTRQSNFS 263
Cdd:COG2770 214 LLLLALLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSRKD-EIGELARAFNRMADSLRESIEEAEEEE 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 264 ADIAHEIRTPITNLVTQTEIALSQSRSQQELEEVLYSNLEEFSRMSRMVSDMLFLAQADNNQLIPEQQALDLADEVHKVF 343
Cdd:COG2770 293 ELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAE 372
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751262903 344 EFFEAWAEEKAVALRFVGSHCRVTGDPLMLRRAISNLLSNAIRYTPAGQAVTIQLSESAETIRLVVENPGTPIAAEHLPR 423
Cdd:COG2770 373 LLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVLALLALALLALAAAAAAAEAAAAALELAAAAIAAAAAAE 452
|
250 260
....*....|....*....|....*
gi 751262903 424 LFDRFYRVDPSRQRKGEGSGIGLAI 448
Cdd:COG2770 453 AEGGLAELEAEELVAAAEALLLLAA 477
|
|
| |
