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Conserved domains on  [gi|751130472|ref|NP_001291375|]
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lysocardiolipin acyltransferase 1 isoform 3 [Homo sapiens]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 10870651)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid

CATH:  1.10.1200.50
EC:  2.3.1.-
Gene Ontology:  GO:0016746|GO:0008654|GO:0006644
PubMed:  18287005|18931347|18718904|37611890
SCOP:  4003349

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 1-124 3.38e-53

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


:

Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 170.50  E-value: 3.38e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130472   1 MQAAAYIFIHRKWKDDKSHFEDMIDYFCDIHEPLQLLIFPEGTDLTENSKSRSNAFAEKNGLQKYEYVLHPRTTGFTFVV 80
Cdd:cd07990   72 WQLGEFIFLKRKWEKDEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKERSQEFAEKNGLPPLKHVLLPRTKGFVAIL 151

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 751130472  81 DRLREGknLDAVHDITVAYPHNIPQSEKHLLQGDFPREIHFHVH 124
Cdd:cd07990  152 ETLRDA--VDAVYDVTIAYPDGKPPSEQRLLLGGKPREVHVHVR 193
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 109-183 1.13e-16

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


:

Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 72.22  E-value: 1.13e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 751130472  109 HLLQGdFPREIHFHVHRYPIDTLPTSKEDLQLWCHKRWEEKEERLRSFYQgEKNFYFTGQSVIPPCKSELRVLVV 183
Cdd:pfam16076   1 SLLNG-KPSEVHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYE-TGTFFPGKEHIIPRRLKSLLVFIF 73
 
Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 1-124 3.38e-53

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 170.50  E-value: 3.38e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130472   1 MQAAAYIFIHRKWKDDKSHFEDMIDYFCDIHEPLQLLIFPEGTDLTENSKSRSNAFAEKNGLQKYEYVLHPRTTGFTFVV 80
Cdd:cd07990   72 WQLGEFIFLKRKWEKDEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKERSQEFAEKNGLPPLKHVLLPRTKGFVAIL 151

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 751130472  81 DRLREGknLDAVHDITVAYPHNIPQSEKHLLQGDFPREIHFHVH 124
Cdd:cd07990  152 ETLRDA--VDAVYDVTIAYPDGKPPSEQRLLLGGKPREVHVHVR 193
PLN02510 PLN02510
probable 1-acyl-sn-glycerol-3-phosphate acyltransferase
 6-203 1.25e-34

probable 1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178126 [Multi-domain]  Cd Length: 374  Bit Score: 127.51  E-value: 1.25e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130472   6 YIFIHRKWKDDKSHFEDMIDYFCDIHEPLQLLIFPEGTDLTENSKSRSNAFAEKNGLQKYEYVLHPRTTGFTFVVDRLRE 85
Cdd:PLN02510 145 FIPVERKWEVDEPNIRQMLSSFKDPRDPLWLALFPEGTDYTEAKCQRSQKFAAEHGLPILNNVLLPKTKGFVSCLQELRC 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130472  86 gkNLDAVHDITVAYPHNIPQSEKHLLQGDfPREIHFHVHRYPIDTLPTSKEDLQLWCHKRWEEKEERLRSFYqgeKNFYF 165
Cdd:PLN02510 225 --SLDAVYDVTIGYKHRCPSFLDNVFGID-PSEVHIHIRRIPLKQIPTSEDEVSAWLMDRFQLKDQLLSDFY---AQGHF 298

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 751130472 166 TGQSV-----IPPCKSELrVLVVKLLSILYWTLFSPAMCLLIY 203
Cdd:PLN02510 299 PNEGTegelsTLKCLANF-LAVIALTTVFTYLTLFSSVWFKIY 340
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 109-183 1.13e-16

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 72.22  E-value: 1.13e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 751130472  109 HLLQGdFPREIHFHVHRYPIDTLPTSKEDLQLWCHKRWEEKEERLRSFYQgEKNFYFTGQSVIPPCKSELRVLVV 183
Cdd:pfam16076   1 SLLNG-KPSEVHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYE-TGTFFPGKEHIIPRRLKSLLVFIF 73
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 1-77 5.04e-04

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 38.88  E-value: 5.04e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 751130472     1 MQAAAYIFIHRKWKDDKSHFedMIDYFCDIHEPLQLLIFPEGTDLTENSKSRSNAFAEKNGLQKYEYVLhPRTTGFT 77
Cdd:smart00563  45 LRLLGAIFIDRSNGRKARAA--LREAVELLKEGEWLLIFPEGTRSRPGKLLPFKKGAARLALEAGVPIV-PVAIRGT 118
 
Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 1-124 3.38e-53

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 170.50  E-value: 3.38e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130472   1 MQAAAYIFIHRKWKDDKSHFEDMIDYFCDIHEPLQLLIFPEGTDLTENSKSRSNAFAEKNGLQKYEYVLHPRTTGFTFVV 80
Cdd:cd07990   72 WQLGEFIFLKRKWEKDEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKERSQEFAEKNGLPPLKHVLLPRTKGFVAIL 151

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 751130472  81 DRLREGknLDAVHDITVAYPHNIPQSEKHLLQGDFPREIHFHVH 124
Cdd:cd07990  152 ETLRDA--VDAVYDVTIAYPDGKPPSEQRLLLGGKPREVHVHVR 193
PLN02510 PLN02510
probable 1-acyl-sn-glycerol-3-phosphate acyltransferase
 6-203 1.25e-34

probable 1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178126 [Multi-domain]  Cd Length: 374  Bit Score: 127.51  E-value: 1.25e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130472   6 YIFIHRKWKDDKSHFEDMIDYFCDIHEPLQLLIFPEGTDLTENSKSRSNAFAEKNGLQKYEYVLHPRTTGFTFVVDRLRE 85
Cdd:PLN02510 145 FIPVERKWEVDEPNIRQMLSSFKDPRDPLWLALFPEGTDYTEAKCQRSQKFAAEHGLPILNNVLLPKTKGFVSCLQELRC 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130472  86 gkNLDAVHDITVAYPHNIPQSEKHLLQGDfPREIHFHVHRYPIDTLPTSKEDLQLWCHKRWEEKEERLRSFYqgeKNFYF 165
Cdd:PLN02510 225 --SLDAVYDVTIGYKHRCPSFLDNVFGID-PSEVHIHIRRIPLKQIPTSEDEVSAWLMDRFQLKDQLLSDFY---AQGHF 298

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 751130472 166 TGQSV-----IPPCKSELrVLVVKLLSILYWTLFSPAMCLLIY 203
Cdd:PLN02510 299 PNEGTegelsTLKCLANF-LAVIALTTVFTYLTLFSSVWFKIY 340
PLN02380 PLN02380
1-acyl-sn-glycerol-3-phosphate acyltransferase
 1-221 1.19e-23

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178006 [Multi-domain]  Cd Length: 376  Bit Score: 97.89  E-value: 1.19e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130472   1 MQAAAYIFIHRKWKDDKSHFEDMIDYFCDIHEPLQLLIFPEGTDLTENSKSRSNAFAEKNGLQKYEYVLHPRTTGFTFVV 80
Cdd:PLN02380 132 MWFSEYVFLERSWAKDENTLKSGFQRLKDFPRPFWLALFVEGTRFTQAKLLAAQEYAASRGLPVPRNVLIPRTKGFVSAV 211

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130472  81 DRLREgkNLDAVHDITVAYPHNIPQ-SEKHLLQGDfPREIHFHVHRYPIDTLPTSKEDLQLWCHKRWEEKEERLRSFyqg 159
Cdd:PLN02380 212 SNMRS--FVPAIYDVTVAVPKGQPApTMLRIFRGQ-SSVVHVHIKRHSMKELPETDDGIAQWCKDVFVAKDALLDKH--- 285

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 751130472 160 EKNFYFTGQSVIP---PCKSelrvlvvkLLSILYWTlfspamCLLIY-LYSLVKWYFI------ITIVIFVL 221
Cdd:PLN02380 286 FAEDTFGDQEYQDigrPKKS--------LIVVISWA------CLLILgAIKFLQWLSLlsswkgIASLAAGL 343
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 109-183 1.13e-16

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 72.22  E-value: 1.13e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 751130472  109 HLLQGdFPREIHFHVHRYPIDTLPTSKEDLQLWCHKRWEEKEERLRSFYQgEKNFYFTGQSVIPPCKSELRVLVV 183
Cdd:pfam16076   1 SLLNG-KPSEVHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYE-TGTFFPGKEHIIPRRLKSLLVFIF 73
PRK14014 PRK14014
putative acyltransferase; Provisional
 31-162 2.18e-09

putative acyltransferase; Provisional


Pssm-ID: 237584 [Multi-domain]  Cd Length: 301  Bit Score: 56.78  E-value: 2.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130472  31 HEPLQLLIFPEGTDLTENSKSRSNAfaeknglqKYEYVLHPRTTGFTFVVDRLreGKNLDAVHDITVAYPHNIPqSEKHL 110
Cdd:PRK14014 172 RMPTTIVNFVEGTRFTPEKHQQQQS--------PYQHLLKPKAGGIAFALNAM--GEQFDGLLDVTIVYPDGRP-SFWDL 240

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130472 111 LQGDfPREIHFHVHRYPIDTL--------PTSKEDLQLWCHKRWEEKEERLRSFYQGEKN 162
Cdd:PRK14014 241 LSGR-VKKIVVHVRLLPIPEEligdyfndKEFRRRFQQWLNQLWQEKDQLIEQLLAQYNQ 299
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 1-77 5.04e-04

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 38.88  E-value: 5.04e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 751130472     1 MQAAAYIFIHRKWKDDKSHFedMIDYFCDIHEPLQLLIFPEGTDLTENSKSRSNAFAEKNGLQKYEYVLhPRTTGFT 77
Cdd:smart00563  45 LRLLGAIFIDRSNGRKARAA--LREAVELLKEGEWLLIFPEGTRSRPGKLLPFKKGAARLALEAGVPIV-PVAIRGT 118
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 1-123 7.88e-03

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 36.24  E-value: 7.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130472   1 MQAAAYIFIHRKW-KDDKSHFEDMIDYFCDIHEplQLLIFPEGTDLTEnsksrsnafaEKNGLQKYEYVLHP-RTTGFTF 78
Cdd:cd06551   70 FTRLGAFSVDRDSpRSAAKSLKYVARLLSKPGS--VVWIFPEGTRTRR----------DKRPLQFKPGVAHLaEKAGVPI 137

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 751130472  79 VVDRLREGKNL-DAVHDITVAYPHNIPQSEKH---LLQGDFPREIHFHV 123
Cdd:cd06551  138 VPVALRYTFELfEQFPEIFVRIGPPIPYAETAlgeELAAELANRLTRLL 186
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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