histone-fold domain found in protein Dr1 and similar proteins; Dr1, also called down-regulator of transcription 1 or negative cofactor 2-beta (NC2-beta), is a TATA-binding protein-associated phosphoprotein and inhibitor of class II gene transcription. It forms a heterodimer with DRAP1. The association of the Dr1/DRAP1 heterodimer with TBP results in functional repression of both activated and basal transcription of class II genes. Dr1 can bind to DNA on its own. Dr1 is a component of the ADA2A-containing complex (ATAC) that has histone acetyltransferase activity on histones H3 and H4.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749723695  20 SSEKRLPKSVIVKALRGGL-GGAKLESDTRELIYTICEEFVKHLVSITLEQSDKVNKKVLAPEHVFAALKEMGYDQHIMK 98
Cdd:cd22905    1 DDDLSLPKATVNKLIKEVLpPDMRVSKDTRELILECCTEFIHLISSEANEICEKEKKKTISPEHVLKALENLGFGEYIEE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 749723695  99 LTEFTQDYNQKMSDRKKKIKLLRdgfKNSGTRQSLVNEQADLIQAAEERRKE 150
Cdd:cd22905   81 VEEALEDHKEEAKKRPKKSNKLK---KSGLTEEELLREQQELFAQARERQES 129

histone-fold domain found in protein Dr1 and similar proteins; Dr1, also called down-regulator of transcription 1 or negative cofactor 2-beta (NC2-beta), is a TATA-binding protein-associated phosphoprotein and inhibitor of class II gene transcription. It forms a heterodimer with DRAP1. The association of the Dr1/DRAP1 heterodimer with TBP results in functional repression of both activated and basal transcription of class II genes. Dr1 can bind to DNA on its own. Dr1 is a component of the ADA2A-containing complex (ATAC) that has histone acetyltransferase activity on histones H3 and H4.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749723695  20 SSEKRLPKSVIVKALRGGL-GGAKLESDTRELIYTICEEFVKHLVSITLEQSDKVNKKVLAPEHVFAALKEMGYDQHIMK 98
Cdd:cd22905    1 DDDLSLPKATVNKLIKEVLpPDMRVSKDTRELILECCTEFIHLISSEANEICEKEKKKTISPEHVLKALENLGFGEYIEE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 749723695  99 LTEFTQDYNQKMSDRKKKIKLLRdgfKNSGTRQSLVNEQADLIQAAEERRKE 150
Cdd:cd22905   81 VEEALEDHKEEAKKRPKKSNKLK---KSGLTEEELLREQQELFAQARERQES 129

Histone-like transcription factor (CBF/NF-Y) and archaeal histone; This family includes archaebacterial histones and histone like transcription factors from eukaryotes.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 749723695   24 RLPKSVIVKALRGGLGGAKLESDTRELIYTICEEFVKHLVSITLEQSDKVNKKVLAPEHVFAAL 87
Cdd:pfam00808   2 ELPIARVKRIMKSDPDAGRISQDAKELIAECVEEFIEFVASEAAEICNKAGRKTINPEHIKQAV 65

histone-fold domain found in protein Dr1 and similar proteins; Dr1, also called down-regulator of transcription 1 or negative cofactor 2-beta (NC2-beta), is a TATA-binding protein-associated phosphoprotein and inhibitor of class II gene transcription. It forms a heterodimer with DRAP1. The association of the Dr1/DRAP1 heterodimer with TBP results in functional repression of both activated and basal transcription of class II genes. Dr1 can bind to DNA on its own. Dr1 is a component of the ADA2A-containing complex (ATAC) that has histone acetyltransferase activity on histones H3 and H4.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749723695  20 SSEKRLPKSVIVKALRGGL-GGAKLESDTRELIYTICEEFVKHLVSITLEQSDKVNKKVLAPEHVFAALKEMGYDQHIMK 98
Cdd:cd22905    1 DDDLSLPKATVNKLIKEVLpPDMRVSKDTRELILECCTEFIHLISSEANEICEKEKKKTISPEHVLKALENLGFGEYIEE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 749723695  99 LTEFTQDYNQKMSDRKKKIKLLRdgfKNSGTRQSLVNEQADLIQAAEERRKE 150
Cdd:cd22905   81 VEEALEDHKEEAKKRPKKSNKLK---KSGLTEEELLREQQELFAQARERQES 129

histone-fold domain found in DNA polymerase epsilon subunit 3 (POLE3) and similar proteins; POLE3, also called arsenic-transactivated protein (AsTP), chromatin accessibility complex 17 kDa protein (CHRAC-17), DNA polymerase II subunit 3, or DNA polymerase epsilon subunit p17, may participate in DNA repair and in chromosomal DNA replication. It is an accessory component of the DNA polymerase epsilon complex, which consists of four subunits: the catalytic subunit POLE and the accessory subunits POLE2, POLE3 and POLE4. It forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1. In fungi, POLE3 has been named as DNA polymerase epsilon subunit D (DPB4, also known as DNA polymerase II subunit D). DPB4 acts as an accessory component of the DNA polymerase epsilon (DNA polymerase II) that consists of POL2, DPB2, DPB3 and DPB4, and participates in chromosomal DNA replication. It also functions as a component of the ISW2 complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749723695  24 RLPKSVIVKALRGGLG-GAKLESDTRELIYTICEEFVKHLVSITLEQSDKVNKKVLAPEHVFAALKEMGYDQHIMKLTEF 102
Cdd:cd22928    4 ELPRAVITRIIKEALPeGVQVSKDARLALSRAATVFILYLTAAANEIAKSNKRKTISADDVLKALEELEFDEFVPPLKEE 83

                 ....
gi 749723695 103 TQDY 106
Cdd:cd22928   84 LEAY 87