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Conserved domains on  [gi|748983008|ref|NP_001291289|]
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cilia- and flagella-associated protein 74 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SMC_N super family cl47134
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 54-353 4.80e-08

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


The actual alignment was detected with superfamily member TIGR02169:

Pssm-ID: 481474 [Multi-domain]  Cd Length: 1164  Bit Score: 58.16  E-value: 4.80e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008    54 KELDTDADKLKKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRrdLIDKQQeavaaeiateeeagnma 133
Cdd:TIGR02169  684 EGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKER--LEELEE----------------- 744

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   134 avgRLQAVSRrlfaELENERDLQSRTEAVLKESENTMWHIEIQEGRLEA------FRTADRE--EVEATGRRLQVRAAE- 204
Cdd:TIGR02169  745 ---DLSSLEQ----EIENVKSELKELEARIEELEEDLHKLEEALNDLEArlshsrIPEIQAElsKLEEEVSRIEARLREi 817

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   205 -------QLCR---EQEALGKVERNRLLRIRKSLNTQK--ELGLRHQKLLEDArKNHKVAVRFLKASLGRIREQEKKEEM 272
Cdd:TIGR02169  818 eqklnrlTLEKeylEKEIQELQEQRIDLKEQIKSIEKEieNLNGKKEELEEEL-EELEAALRDLESRLGDLKKERDELEA 896

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   273 ECHEyMRRRmdavvalKGSISANRDTLRKFQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVH---QRRRQELEAQKR 349
Cdd:TIGR02169  897 QLRE-LERK-------IEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPEEELSLedvQAELQRVEEEIR 968


                   ....
gi 748983008   350 AFEE 353
Cdd:TIGR02169  969 ALEP 972
 
Name Accession Description Interval E-value
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 54-353 4.80e-08

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 58.16  E-value: 4.80e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008    54 KELDTDADKLKKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRrdLIDKQQeavaaeiateeeagnma 133
Cdd:TIGR02169  684 EGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKER--LEELEE----------------- 744

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   134 avgRLQAVSRrlfaELENERDLQSRTEAVLKESENTMWHIEIQEGRLEA------FRTADRE--EVEATGRRLQVRAAE- 204
Cdd:TIGR02169  745 ---DLSSLEQ----EIENVKSELKELEARIEELEEDLHKLEEALNDLEArlshsrIPEIQAElsKLEEEVSRIEARLREi 817

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   205 -------QLCR---EQEALGKVERNRLLRIRKSLNTQK--ELGLRHQKLLEDArKNHKVAVRFLKASLGRIREQEKKEEM 272
Cdd:TIGR02169  818 eqklnrlTLEKeylEKEIQELQEQRIDLKEQIKSIEKEieNLNGKKEELEEEL-EELEAALRDLESRLGDLKKERDELEA 896

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   273 ECHEyMRRRmdavvalKGSISANRDTLRKFQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVH---QRRRQELEAQKR 349
Cdd:TIGR02169  897 QLRE-LERK-------IEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPEEELSLedvQAELQRVEEEIR 968


                   ....
gi 748983008   350 AFEE 353
Cdd:TIGR02169  969 ALEP 972
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 54-361 2.62e-07

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 54.54  E-value: 2.62e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008    54 KELDTDADKLKKKTAEDRTQAFHLRQnlsALDKMHEEQElftekmrgELRACRQRRDLIDKQQeavaaeiateeeagnma 133
Cdd:pfam13868   51 EERERALEEEEEKEEERKEERKRYRQ---ELEEQIEERE--------QKRQEEYEEKLQEREQ----------------- 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   134 avgrLQAVSRRLfaELENERDLQSRTEAVLKESEntmwhiEIQEG--RLEAFRTADREEVEATGRRLQVRAAEQLCREQE 211
Cdd:pfam13868  103 ----MDEIVERI--QEEDQAEAEEKLEKQRQLRE------EIDEFneEQAEWKELEKEEEREEDERILEYLKEKAEREEE 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   212 ALGKVERnrlLRIRKSLNTQKelgLRHQKLLEDARKNHKVAVRFLKAslgrIREQEKKEEMECHEYMRRRMDAVVALKGS 291
Cdd:pfam13868  171 REAEREE---IEEEKEREIAR---LRAQQEKAQDEKAERDELRAKLY----QEEQERKERQKEREEAEKKARQRQELQQA 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   292 ----ISANRDTLRKFQAWDR----------AKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQELEAQKRAFEEEQKL 357
Cdd:pfam13868  241 reeqIELKERRLAEEAEREEeefermlrkqAEDEEIEQEEAEKRRMKRLEHRRELEKQIEEREEQRAAEREEELEEGERL 320


                   ....
gi 748983008   358 RKQE 361
Cdd:pfam13868  321 REEE 324
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 133-365 1.92e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 53.02  E-value: 1.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008  133 AAVGRLQAVSRRLfAELENERDLQSRTEAVLkESENTMWHIEIQEGRLEafRTADREEVEATGRRLQVRAAEQL-CREQE 211
Cdd:COG1196   229 LLLLKLRELEAEL-EELEAELEELEAELEEL-EAELAELEAELEELRLE--LEELELELEEAQAEEYELLAELArLEQDI 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008  212 ALGKVERNRLLRIRKSLNTQKELGLRHQKLLEDARKNHKVAVRFLKASLGRIREQEKKEEmecheymRRRMDAVVALKGS 291
Cdd:COG1196   305 ARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAE-------EALLEAEAELAEA 377

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 748983008  292 ISANRDTLRKFQAWDRAKAELAEQRVQAEKKAILAQGRDAfrhlVHQRRRQELEAQKRAFEEEQKLRKQEIISR 365
Cdd:COG1196   378 EEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLE----RLEEELEELEEALAELEEEEEEEEEALEEA 447
PTZ00121 PTZ00121
MAEBL; Provisional
 60-372 5.09e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 51.68  E-value: 5.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   60 ADKLKKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGElracrqrrDLIDKQQEAVAaeiateeeagnmAAVGRLQ 139
Cdd:PTZ00121 1393 ADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKAD--------EAKKKAEEAKK------------ADEAKKK 1452

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008  140 AVSRRLFAELENERDLQSRTEAVLKESENTMWHIEIQEGRLEAFRTAD--REEVEATGRRLQVRAAEQLCREQEALGKVE 217
Cdd:PTZ00121 1453 AEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADeaKKAAEAKKKADEAKKAEEAKKADEAKKAEE 1532

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008  218 RNRLLRIRKSLNTQKELGLRHQKLLEDARKNHKVavrflkaslgrirEQEKKEEMECHEYMRRrmdAVVALKGSISANRD 297
Cdd:PTZ00121 1533 AKKADEAKKAEEKKKADELKKAEELKKAEEKKKA-------------EEAKKAEEDKNMALRK---AEEAKKAEEARIEE 1596

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008  298 TLRKFQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQELEAQKRA-----FEEEQKLRKQEiisriLKEEAE 372
Cdd:PTZ00121 1597 VMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAeelkkAEEENKIKAAE-----EAKKAE 1671
 
Name Accession Description Interval E-value
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 54-353 4.80e-08

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 58.16  E-value: 4.80e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008    54 KELDTDADKLKKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRrdLIDKQQeavaaeiateeeagnma 133
Cdd:TIGR02169  684 EGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKER--LEELEE----------------- 744

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   134 avgRLQAVSRrlfaELENERDLQSRTEAVLKESENTMWHIEIQEGRLEA------FRTADRE--EVEATGRRLQVRAAE- 204
Cdd:TIGR02169  745 ---DLSSLEQ----EIENVKSELKELEARIEELEEDLHKLEEALNDLEArlshsrIPEIQAElsKLEEEVSRIEARLREi 817

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   205 -------QLCR---EQEALGKVERNRLLRIRKSLNTQK--ELGLRHQKLLEDArKNHKVAVRFLKASLGRIREQEKKEEM 272
Cdd:TIGR02169  818 eqklnrlTLEKeylEKEIQELQEQRIDLKEQIKSIEKEieNLNGKKEELEEEL-EELEAALRDLESRLGDLKKERDELEA 896

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   273 ECHEyMRRRmdavvalKGSISANRDTLRKFQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVH---QRRRQELEAQKR 349
Cdd:TIGR02169  897 QLRE-LERK-------IEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPEEELSLedvQAELQRVEEEIR 968


                   ....
gi 748983008   350 AFEE 353
Cdd:TIGR02169  969 ALEP 972
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 54-361 2.62e-07

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 54.54  E-value: 2.62e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008    54 KELDTDADKLKKKTAEDRTQAFHLRQnlsALDKMHEEQElftekmrgELRACRQRRDLIDKQQeavaaeiateeeagnma 133
Cdd:pfam13868   51 EERERALEEEEEKEEERKEERKRYRQ---ELEEQIEERE--------QKRQEEYEEKLQEREQ----------------- 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   134 avgrLQAVSRRLfaELENERDLQSRTEAVLKESEntmwhiEIQEG--RLEAFRTADREEVEATGRRLQVRAAEQLCREQE 211
Cdd:pfam13868  103 ----MDEIVERI--QEEDQAEAEEKLEKQRQLRE------EIDEFneEQAEWKELEKEEEREEDERILEYLKEKAEREEE 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   212 ALGKVERnrlLRIRKSLNTQKelgLRHQKLLEDARKNHKVAVRFLKAslgrIREQEKKEEMECHEYMRRRMDAVVALKGS 291
Cdd:pfam13868  171 REAEREE---IEEEKEREIAR---LRAQQEKAQDEKAERDELRAKLY----QEEQERKERQKEREEAEKKARQRQELQQA 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   292 ----ISANRDTLRKFQAWDR----------AKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQELEAQKRAFEEEQKL 357
Cdd:pfam13868  241 reeqIELKERRLAEEAEREEeefermlrkqAEDEEIEQEEAEKRRMKRLEHRRELEKQIEEREEQRAAEREEELEEGERL 320


                   ....
gi 748983008   358 RKQE 361
Cdd:pfam13868  321 REEE 324
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 133-365 1.92e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 53.02  E-value: 1.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008  133 AAVGRLQAVSRRLfAELENERDLQSRTEAVLkESENTMWHIEIQEGRLEafRTADREEVEATGRRLQVRAAEQL-CREQE 211
Cdd:COG1196   229 LLLLKLRELEAEL-EELEAELEELEAELEEL-EAELAELEAELEELRLE--LEELELELEEAQAEEYELLAELArLEQDI 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008  212 ALGKVERNRLLRIRKSLNTQKELGLRHQKLLEDARKNHKVAVRFLKASLGRIREQEKKEEmecheymRRRMDAVVALKGS 291
Cdd:COG1196   305 ARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAE-------EALLEAEAELAEA 377

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 748983008  292 ISANRDTLRKFQAWDRAKAELAEQRVQAEKKAILAQGRDAfrhlVHQRRRQELEAQKRAFEEEQKLRKQEIISR 365
Cdd:COG1196   378 EEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLE----RLEEELEELEEALAELEEEEEEEEEALEEA 447
PTZ00121 PTZ00121
MAEBL; Provisional
 60-372 5.09e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 51.68  E-value: 5.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   60 ADKLKKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGElracrqrrDLIDKQQEAVAaeiateeeagnmAAVGRLQ 139
Cdd:PTZ00121 1393 ADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKAD--------EAKKKAEEAKK------------ADEAKKK 1452

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008  140 AVSRRLFAELENERDLQSRTEAVLKESENTMWHIEIQEGRLEAFRTAD--REEVEATGRRLQVRAAEQLCREQEALGKVE 217
Cdd:PTZ00121 1453 AEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADeaKKAAEAKKKADEAKKAEEAKKADEAKKAEE 1532

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008  218 RNRLLRIRKSLNTQKELGLRHQKLLEDARKNHKVavrflkaslgrirEQEKKEEMECHEYMRRrmdAVVALKGSISANRD 297
Cdd:PTZ00121 1533 AKKADEAKKAEEKKKADELKKAEELKKAEEKKKA-------------EEAKKAEEDKNMALRK---AEEAKKAEEARIEE 1596

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008  298 TLRKFQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQELEAQKRA-----FEEEQKLRKQEiisriLKEEAE 372
Cdd:PTZ00121 1597 VMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAeelkkAEEENKIKAAE-----EAKKAE 1671
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 137-366 1.14e-05

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 50.12  E-value: 1.14e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   137 RLQAVSRRLFAELENERDLQSRTEAVLKESE-NTMWHIEIQEGRLEAFRTADREEVEATGRRLQVRAAEQLCREQEALGK 215
Cdd:pfam17380  300 RLRQEKEEKAREVERRRKLEEAEKARQAEMDrQAAIYAEQERMAMERERELERIRQEERKRELERIRQEEIAMEISRMRE 379

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   216 VERNRLLRIRKSLNTQKEL-GLRHQKLLEDARKN-------------------HKVAVRFLKASLGRIREQEKKEEMECH 275
Cdd:pfam17380  380 LERLQMERQQKNERVRQELeAARKVKILEEERQRkiqqqkvemeqiraeqeeaRQREVRRLEEERAREMERVRLEEQERQ 459

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   276 EYMRR-RMDAVVALKGSISANRDTlRKFQAWDRAKAELAEQRVQAEKKAILAQGR------------------DAFRHLV 336
Cdd:pfam17380  460 QQVERlRQQEEERKRKKLELEKEK-RDRKRAEEQRRKILEKELEERKQAMIEEERkrkllekemeerqkaiyeEERRREA 538

                          250       260       270
                   ....*....|....*....|....*....|
gi 748983008   337 HQRRRQELEAQKRAFEEEQKLRKQEIISRI 366
Cdd:pfam17380  539 EEERRKQQEMEERRRIQEQMRKATEERSRL 568
PTZ00121 PTZ00121
MAEBL; Provisional
 181-356 3.80e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 48.98  E-value: 3.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008  181 EAFRTADREEVEATGRRLQVRAAEQL-----CREQEALGKVERNRllRIRKSLNTQKELGLRHQKLLEDARKNHKVAVRf 255
Cdd:PTZ00121 1168 EARKAEDAKKAEAARKAEEVRKAEELrkaedARKAEAARKAEEER--KAEEARKAEDAKKAEAVKKAEEAKKDAEEAKK- 1244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008  256 lkASLGRIREQEKKEEMECHEYMRRRMDAVvalKGSISANRDTLRKFQAWDRA----KAELAEQRVQAEKKAILAQGRDA 331
Cdd:PTZ00121 1245 --AEEERNNEEIRKFEEARMAHFARRQAAI---KAEEARKADELKKAEEKKKAdeakKAEEKKKADEAKKKAEEAKKADE 1319

                         170       180
                  ....*....|....*....|....*
gi 748983008  332 FRHLVHQRRRQELEAQKRAFEEEQK 356
Cdd:PTZ00121 1320 AKKKAEEAKKKADAAKKKAEEAKKA 1344
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 53-349 4.95e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 48.39  E-value: 4.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   53 VKELDTDADKLKKKTAEDRTQAFHLRQNLSALDK-MHEEQELF------TEKMRGELRACRQRRDLIDKQQEavaaeiat 125
Cdd:COG1196   248 LEELEAELEELEAELAELEAELEELRLELEELELeLEEAQAEEyellaeLARLEQDIARLEERRRELEERLE-------- 319

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008  126 eeeagnmaavgRLQAVSRRLFAELENERDLQSRTEAVLKESEntmwhiEIQEGRLEAFRTADREEVEATGRRLQVRAAEQ 205
Cdd:COG1196   320 -----------ELEEELAELEEELEELEEELEELEEELEEAE------EELEEAEAELAEAEEALLEAEAELAEAEEELE 382

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008  206 LCREQEAlgkverNRLLRIRKSLNTQKELGLRHQKLLEDaRKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAV 285
Cdd:COG1196   383 ELAEELL------EALRAAAELAAQLEELEEAEEALLER-LERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELE 455

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 748983008  286 VALKGSISANRDTLRKFQAWDRAKAELAEQRVQAE-KKAILAQGRDAFRHLVHQRRRQELEAQKR 349
Cdd:COG1196   456 EEEEALLELLAELLEEAALLEAALAELLEELAEAAaRLLLLLEAEADYEGFLEGVKAALLLAGLR 520
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 91-360 1.78e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 46.47  E-value: 1.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   91 QELFTEKMRGELRACRQRRDLIDKQQEAVAaeiateeeagnmAAVGRLQAVSRRLFAELEN-ERDLQSRTEAVLKESEnt 169
Cdd:COG1196   216 RELKEELKELEAELLLLKLRELEAELEELE------------AELEELEAELEELEAELAElEAELEELRLELEELEL-- 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008  170 mwhiEIQEGRLEAFRTADREEVEATGRRLQVRAAEQLCREQEALgkveRNRLLRIRKSLNTQKELGLRHQKLLEDARKNH 249
Cdd:COG1196   282 ----ELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEEL----EEELAELEEELEELEEELEELEEELEEAEEEL 353

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008  250 KVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISANRDTLRKFQAWDRAKAELAEQRVQAEKKAILAQGR 329
Cdd:COG1196   354 EEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAEL 433

                         250       260       270
                  ....*....|....*....|....*....|.
gi 748983008  330 DAFRHLVHQRRRQELEAQKRAFEEEQKLRKQ 360
Cdd:COG1196   434 EEEEEEEEEALEEAAEEEAELEEEEEALLEL 464
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 53-361 2.67e-04

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 46.10  E-value: 2.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   53 VKELDTDADKLKKKTAE---DRTQAFHLRQNLSALDKMHEeQELFTEKMRGELRACRQRRDLIDKQQEAVAAEIATEEEA 129
Cdd:COG3096   787 LEELRAERDELAEQYAKasfDVQKLQRLHQAFSQFVGGHL-AVAFAPDPEAELAALRQRRSELERELAQHRAQEQQLRQQ 865

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008  130 GNmAAVGRLQAVSRRL-FAELENERDLQSRTEAV------LKESENTMW----HIEIQEGRLEAFRT---------ADRE 189
Cdd:COG3096   866 LD-QLKEQLQLLNKLLpQANLLADETLADRLEELreeldaAQEAQAFIQqhgkALAQLEPLVAVLQSdpeqfeqlqADYL 944

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008  190 EVEATGRRLQVR--AAEQLCREQEALGKVERNRLLRIRKSLNTQkelgLRHQklLEDArknhkvavrflKASLGRIREQE 267
Cdd:COG3096   945 QAKEQQRRLKQQifALSEVVQRRPHFSYEDAVGLLGENSDLNEK----LRAR--LEQA-----------EEARREAREQL 1007

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008  268 KKEEMECHEYMRRRMDavvaLKGSISANRDTLRKFqawdraKAELAEQRVQAEKKA-ILAQGRDAFRH--LVHQR-RRQE 343
Cdd:COG3096  1008 RQAQAQYSQYNQVLAS----LKSSRDAKQQTLQEL------EQELEELGVQADAEAeERARIRRDELHeeLSQNRsRRSQ 1077

                         330       340
                  ....*....|....*....|...
gi 748983008  344 LEAQKRAFEEE-----QKLRKQE 361
Cdd:COG3096  1078 LEKQLTRCEAEmdslqKRLRKAE 1100
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
50-367 3.44e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 44.89  E-value: 3.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   50 SSSVKELDTDADKLKKKTAEDRTQAFHLRQNLSALdkmheEQELftEKMRGELRACRQRRDLIDKQqeavaaeiateeea 129
Cdd:COG4372    30 SEQLRKALFELDKLQEELEQLREELEQAREELEQL-----EEEL--EQARSELEQLEEELEELNEQ-------------- 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008  130 gnMAAVGRLQAVSRRLFAELENERD-LQSRTEAVLKESENtmwhIEIQEGRLEAFRTADREEVEATGRRLQvRAAEQLCR 208
Cdd:COG4372    89 --LQAAQAELAQAQEELESLQEEAEeLQEELEELQKERQD----LEQQRKQLEAQIAELQSEIAEREEELK-ELEEQLES 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008  209 EQEALGKVERNRLLRIRKSLNTQKElglrhqKLLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVAL 288
Cdd:COG4372   162 LQEELAALEQELQALSEAEAEQALD------ELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLAL 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008  289 KGSISANRDTLRKFQA------WDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQELEAQKRAFEEEQKLRKQEI 362
Cdd:COG4372   236 SALLDALELEEDKEELleevilKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALED 315


                  ....*
gi 748983008  363 ISRIL 367
Cdd:COG4372   316 ALLAA 320
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
24-362 6.40e-04

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 44.65  E-value: 6.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   24 RDELEDPEfdikcllQEAEDDVDPgHSSSVKELDTDADKLKKKTAEDRTQAFHLRQNLSALDKmheeqELftEKMRGELR 103
Cdd:PRK02224  316 REELEDRD-------EELRDRLEE-CRVAAQAHNEEAESLREDADDLEERAEELREEAAELES-----EL--EEAREAVE 380

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008  104 ACRQRRDLIDKQqeavaaeiateeEAGNMAAVG----RLQAVSRRLFAELENERDLQSR---TEAVLKESENTmwhieIQ 176
Cdd:PRK02224  381 DRREEIEELEEE------------IEELRERFGdapvDLGNAEDFLEELREERDELREReaeLEATLRTARER-----VE 443

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008  177 EGR--LEAFR-----------------TADREEVEATGRRLQVRAAEQLCREQ-----EALGKVERnrllRIRKSLNTQK 232
Cdd:PRK02224  444 EAEalLEAGKcpecgqpvegsphvetiEEDRERVEELEAELEDLEEEVEEVEErleraEDLVEAED----RIERLEERRE 519

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008  233 ELglrhQKLLEDARKnhKVAVRFLKASLGRIREQEKKEEMECHEymrrrmDAVVALKGSISANRDTLRKFqawDRAKAEL 312
Cdd:PRK02224  520 DL----EELIAERRE--TIEEKRERAEELRERAAELEAEAEEKR------EAAAEAEEEAEEAREEVAEL---NSKLAEL 584

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 748983008  313 AEQRVQAEKKAILAQGRDAFRHLVHQRR-----RQELEAQKRAFEEEQKLRKQEI 362
Cdd:PRK02224  585 KERIESLERIRTLLAAIADAEDEIERLRekreaLAELNDERRERLAEKRERKREL 639
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 24-357 1.03e-03

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 43.79  E-value: 1.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008    24 RDELEDPEFDIKCLLQEAEDDVDPGHSSSVKELDT-DADKLKKKTAEDRTQAF--HLRQNLSALDKMHEEQelfTEKMRG 100
Cdd:pfam15709  272 DSVVEDPWLSSKYDAEESQVSIDGRSSPTQTFVVTgNMESEEERSEEDPSKALleKREQEKASRDRLRAER---AEMRRL 348

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   101 ELRACRQRRDLIDKQQEAVaaeiateeeagnmaavgrlQAVSRRLFAELENERdlQSRTEAvlkesentmwhIEIQEGRL 180
Cdd:pfam15709  349 EVERKRREQEEQRRLQQEQ-------------------LERAEKMREELELEQ--QRRFEE-----------IRLRKQRL 396

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   181 EAFRtaDREEVEATGRRLQVRAAEQLCREQealgkvernrllrirkslntQKELglrHQKLLEDARKNHKVAVRFLKASl 260
Cdd:pfam15709  397 EEER--QRQEEEERKQRLQLQAAQERARQQ--------------------QEEF---RRKLQELQRKKQQEEAERAEAE- 450

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   261 griREQEKKEEMECHEYMRRRMDAVvalkgsisanrdtlrkfqawDRAKAELAEQRVQAEKKAILAqgrdafrhlVHQRR 340
Cdd:pfam15709  451 ---KQRQKELEMQLAEEQKRLMEMA--------------------EEERLEYQRQKQEAEEKARLE---------AEERR 498

                          330
                   ....*....|....*..
gi 748983008   341 RQELEAQKRAFEEEQKL 357
Cdd:pfam15709  499 QKEEEAARLALEEAMKQ 515
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 67-362 1.38e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 43.67  E-value: 1.38e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008    67 TAEDRTQafhLRQNLSALDKMHEEQELFT---EKMRGELRACRQRRDlidkqqeavaaeiateeeagnmAAVGRLQAVSR 143
Cdd:pfam12128  459 TPELLLQ---LENFDERIERAREEQEAANaevERLQSELRQARKRRD----------------------QASEALRQASR 513

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   144 RLfaeleneRDLQSRTEAVlkesentMWHIEIQEGRLEAF-RTADREEVEATGRrlqVRAAEQLCREQ------EALGKV 216
Cdd:pfam12128  514 RL-------EERQSALDEL-------ELQLFPQAGTLLHFlRKEAPDWEQSIGK---VISPELLHRTDldpevwDGSVGG 576

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   217 ERN------RLLRIR--KSLNTQKELGLRHQKL---LEDARKNHKVAVRFLKASLGRIREQEKKEEmecheymrrrmDAV 285
Cdd:pfam12128  577 ELNlygvklDLKRIDvpEWAASEEELRERLDKAeeaLQSAREKQAAAEEQLVQANGELEKASREET-----------FAR 645

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 748983008   286 VALKGsisaNRDTLRKFQAWDRAKAELAEQRVQAEKKAIlaqgrdafrhlvhQRRRQELEAQKRAFEEEQKLRKQEI 362
Cdd:pfam12128  646 TALKN----ARLDLRRLFDEKQSEKDKKNKALAERKDSA-------------NERLNSLEAQLKQLDKKHQAWLEEQ 705
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
136-367 1.47e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 43.22  E-value: 1.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008  136 GRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIEIQEGRLEAFRTADREEVEATGRRLQVRAAEQlcreqealgk 215
Cdd:COG4717    63 GRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQ---------- 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008  216 vERNRLLRIRKSLNTQKELGLRHQKLLEDARKnhkvAVRFLKASLGRIREQEKKEEMECHEYMRRRMdavvalkgsisan 295
Cdd:COG4717   133 -ELEALEAELAELPERLEELEERLEELRELEE----ELEELEAELAELQEELEELLEQLSLATEEEL------------- 194

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 748983008  296 RDTLRKFQAWDRAKAEL--AEQRVQAEKKAIlaqgrdafrhlvhQRRRQELEAQKRAFEEEQKLRKQEIISRIL 367
Cdd:COG4717   195 QDLAEELEELQQRLAELeeELEEAQEELEEL-------------EEELEQLENELEAAALEERLKEARLLLLIA 255
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 172-366 1.51e-03

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 42.60  E-value: 1.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   172 HIEIQEGRLEAFRTADREEVEATGRRLQV---RAAEQLCRE-QEALGKVERNRLLRIRKSLNTQKELglrHQKLLEDARK 247
Cdd:pfam13868   12 NSKLLAAKCNKERDAQIAEKKRIKAEEKEeerRLDEMMEEErERALEEEEEKEEERKEERKRYRQEL---EEQIEEREQK 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   248 NHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISANRDtLRKFQAWDRAKAELAEQRVQAekkailaq 327
Cdd:pfam13868   89 RQEEYEEKLQEREQMDEIVERIQEEDQAEAEEKLEKQRQLREEIDEFNEE-QAEWKELEKEEEREEDERILE-------- 159

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 748983008   328 grdafrhlvHQRRRQELEAQKRAFEEEQKLRKQEIISRI 366
Cdd:pfam13868  160 ---------YLKEKAEREEEREAEREEIEEEKEREIARL 189
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 53-359 1.73e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 43.13  E-value: 1.73e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008    53 VKELDTDADKLK--KKTAEdRTQAFHLR-QNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEIATEeea 129
Cdd:TIGR02169  193 IDEKRQQLERLRreREKAE-RYQALLKEkREYEGYELLKEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLE--- 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   130 gnmAAVGRLQAVSRRLFAELENE-RDLQSRTEAVLKESENTMWHIEIQEGRLEafrTADREEVEATGRRLQVRA-AEQLC 207
Cdd:TIGR02169  269 ---EIEQLLEELNKKIKDLGEEEqLRVKEKIGELEAEIASLERSIAEKERELE---DAEERLAKLEAEIDKLLAeIEELE 342

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   208 REQEALgKVERNRLLRIRKSLNTQKELgLRHQklLEDARKNHKVAVRFLKA------SLGRIREQEKKEEMECHEYMRRR 281
Cdd:TIGR02169  343 REIEEE-RKRRDKLTEEYAELKEELED-LRAE--LEEVDKEFAETRDELKDyrekleKLKREINELKRELDRLQEELQRL 418

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   282 MDAVVALKGSISANRDTLRKFQA-WDRAKAELAEQRVQAEK-KAILAQGRDAFRHL----------VHQRRRQ--ELEAQ 347
Cdd:TIGR02169  419 SEELADLNAAIAGIEAKINELEEeKEDKALEIKKQEWKLEQlAADLSKYEQELYDLkeeydrvekeLSKLQRElaEAEAQ 498

                          330
                   ....*....|..
gi 748983008   348 KRAFEEEQKLRK 359
Cdd:TIGR02169  499 ARASEERVRGGR 510
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 142-361 2.64e-03

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 42.25  E-value: 2.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   142 SRRLFAELENERDLQSRteavLKESENTMWHIEIQEGRLEafrtadREEveatGRRLQVRAAEQLCREQEALGKVERNRL 221
Cdd:pfam15709  321 SKALLEKREQEKASRDR----LRAERAEMRRLEVERKRRE------QEE----QRRLQQEQLERAEKMREELELEQQRRF 386

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   222 LRIRKSLNTQKELGLRHQkllEDARKNHkvavRFLKASLGRIREQEKKEEMECHEYMRRRmdavvalkgsisaNRDTLRK 301
Cdd:pfam15709  387 EEIRLRKQRLEEERQRQE---EEERKQR----LQLQAAQERARQQQEEFRRKLQELQRKK-------------QQEEAER 446

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   302 FQAWDRAKAELAEQRvqAEKKAILAQGRDAFRhLVHQRRRQELEAQKRAFEEEQKLRKQE 361
Cdd:pfam15709  447 AEAEKQRQKELEMQL--AEEQKRLMEMAEEER-LEYQRQKQEAEEKARLEAEERRQKEEE 503
DUF4659 pfam15558
Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins ...
 62-370 6.95e-03

Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins in this family are typically between 427 and 674 amino acids in length. There are two completely conserved residues (D and I) that may be functionally important.


Pssm-ID: 464768 [Multi-domain]  Cd Length: 374  Bit Score: 40.79  E-value: 6.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008    62 KLKK--KTAEDRTQAFHLRQNLSALDKMHEEQElftEKMRGELRACRQRRDLIDKQQEAvaaeiateeeagnmaavgrlq 139
Cdd:pfam15558   16 RHKEeqRMRELQQQAALAWEELRRRDQKRQETL---ERERRLLLQQSQEQWQAEKEQRK--------------------- 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   140 avsRRLFAELENERDLQSRtEAVLKESENTMwHIEIQEGRLEafRTADREEVEATGRRLQvraAEQLCREQEALGKV--E 217
Cdd:pfam15558   72 ---ARLGREERRRADRREK-QVIEKESRWRE-QAEDQENQRQ--EKLERARQEAEQRKQC---QEQRLKEKEEELQAlrE 141

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   218 RNRLLRIRKSLNTqkelglRHQKLLEDARKNHKVAVRFLKAslgRIREQEKKEEMECHEYMRRRMdavvaLKGSISAN-- 295
Cdd:pfam15558  142 QNSLQLQERLEEA------CHKRQLKEREEQKKVQENNLSE---LLNHQARKVLVDCQAKAEELL-----RRLSLEQSlq 207

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   296 -----------------RDTLRK----FQawdRAK--AELAEQRVQAEKKAiLAQGRDafRHLVHQRRRQELEAQKRAFE 352
Cdd:pfam15558  208 rsqenyeqlveerhrelREKAQKeeeqFQ---RAKwrAEEKEEERQEHKEA-LAELAD--RKIQQARQVAHKTVQDKAQR 281

                          330
                   ....*....|....*...
gi 748983008   353 EEQKLRKQEIISRILKEE 370
Cdd:pfam15558  282 ARELNLEREKNHHILKLK 299
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 208-365 9.22e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 40.69  E-value: 9.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008  208 REQEALGKVE--RNRLLRIR----------KSLNTQKELGLRHQKLLEDARKNHK----VAVRFLKASLGRIREQEKKEE 271
Cdd:COG1196   173 RKEEAERKLEatEENLERLEdilgelerqlEPLERQAEKAERYRELKEELKELEAelllLKLRELEAELEELEAELEELE 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008  272 MEcheyMRRRMDAVVALKGSISANRDTLRKFQawDRAKAELAEQRVQAEKKAILAQGRDafrhlVHQRRRQELEAQKRAF 351
Cdd:COG1196   253 AE----LEELEAELAELEAELEELRLELEELE--LELEEAQAEEYELLAELARLEQDIA-----RLEERRRELEERLEEL 321

                         170
                  ....*....|....
gi 748983008  352 EEEQKLRKQEIISR 365
Cdd:COG1196   322 EEELAELEEELEEL 335
Caldesmon pfam02029
Caldesmon;
150-365 9.76e-03

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 40.62  E-value: 9.76e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   150 ENERDLQSRTEAVLKESENTMWHIEIQEGRLEAFRTADREEvEATGRRLQVRAAEQLCREQEalgKVERNRLLRIRKSLN 229
Cdd:pfam02029  124 RLGRYKEEETEIREKEYQENKWSTEVRQAEEEGEEEEDKSE-EAEEVPTENFAKEEVKDEKI---KKEKKVKYESKVFLD 199

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983008   230 TQKELGLRHQKLLEDARKNHKVAVRFLKASLGRIREQEKKEEMECH-----EYMRRRMDAvvalkgsiSANRDTLRKFQA 304
Cdd:pfam02029  200 QKRGHPEVKSQNGEEEVTKLKVTTKRRQGGLSQSQEREEEAEVFLEaeqklEELRRRRQE--------KESEEFEKLRQK 271

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 748983008   305 WDRAKAELAE-QRVQAEKKAILAQGRdafrhlvhQRRRQElEAQKRAFEEEQKLRKQEIISR 365
Cdd:pfam02029  272 QQEAELELEElKKKREERRKLLEEEE--------QRRKQE-EAERKLREEEEKRRMKEEIER 324
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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