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Conserved domains on  [gi|748714426|ref|WP_039972546|]
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MULTISPECIES: L-fucose:H+ symporter permease [Pseudoalteromonas]

Protein Classification

sugar MFS transporter( domain architecture ID 13024430)

sugar major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of sugar substrates including glucose, galactose, mannose and fucose

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_FucP_like cd17394
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ...
 20-418 2.13e-131

Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340952 [Multi-domain]  Cd Length: 401  Bit Score: 384.27  E-value: 2.13e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426  20 FILLVLCFAAWGAAANMTDPLVKVFSKIFTMSSVQSALVQFSYYGAYFCLAIPAAYINKRFSYKVGVLTGLGMAAMGAFM 99
Cdd:cd17394    1 LALVTSLFFLWGFATNLNDILIPQFKNIFDLSNFQASLVQFAFFGAYFIMAIPAGMLIKRYGYKKGILLGLGLYAIGALL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 100 FYPASQAMTYGFFLAALFILAGGLSILETSANPYVMGMGNEQSATRRLNLAQSFNPVGTNIGVFLAATLILPSLNTATSD 179
Cdd:cd17394   81 FIPAASLRTYGLFLIALFVLASGLALLQTAANPYVTVLGPEETAARRLNLAQAFNSLGSTIAPLFGSYLILSGIPSTATA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 180 ERsSMTTSQLKNIISAELDAVMVPYVGMACVLVFIWLAIAFTKTPDfCKKKQVSKHvDFKPAFKRLFKNTHYRFGVIAQF 259
Cdd:cd17394  161 LA-AMSAAELQAYKTAELASVQLPYLGIALVLLLLAVLILLSKLPE-IEAAEAEAL-GSKGTLLRLLKNPHLRLGVLAIF 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 260 FNVAAQTCVWTFTIQYVMEA-LNTNEVSGGTILQYSMITFLVSRFVMTWLMGFIRPAKLLMATSLIAMMLCIYMVQMPNI 338
Cdd:cd17394  238 FYVGAEVAIWSFLINYLMEYiAGLTETSAATFVSYYWGGFMVGRFLGTALLKKISPKKLLAVFALLGLLLLLGAIFTGGM 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 339 SGVWALVCISACLSLMFPTIYAIALHGLGDDAKLGAAGLVMAILGGAIVPVIQAVFI-DTYSVAFSYMVPAGCFIVVAAY 417
Cdd:cd17394  318 VALYALVLVGFFNSIMFPTIFSLALKGLGKHTKTGSGLLVMAIVGGAVVPLIQGAVAdDAAGLRIAFLVPLLCFAYILFY 397


                 .
gi 748714426 418 A 418
Cdd:cd17394  398 G 398
 
Name Accession Description Interval E-value
MFS_FucP_like cd17394
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ...
 20-418 2.13e-131

Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340952 [Multi-domain]  Cd Length: 401  Bit Score: 384.27  E-value: 2.13e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426  20 FILLVLCFAAWGAAANMTDPLVKVFSKIFTMSSVQSALVQFSYYGAYFCLAIPAAYINKRFSYKVGVLTGLGMAAMGAFM 99
Cdd:cd17394    1 LALVTSLFFLWGFATNLNDILIPQFKNIFDLSNFQASLVQFAFFGAYFIMAIPAGMLIKRYGYKKGILLGLGLYAIGALL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 100 FYPASQAMTYGFFLAALFILAGGLSILETSANPYVMGMGNEQSATRRLNLAQSFNPVGTNIGVFLAATLILPSLNTATSD 179
Cdd:cd17394   81 FIPAASLRTYGLFLIALFVLASGLALLQTAANPYVTVLGPEETAARRLNLAQAFNSLGSTIAPLFGSYLILSGIPSTATA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 180 ERsSMTTSQLKNIISAELDAVMVPYVGMACVLVFIWLAIAFTKTPDfCKKKQVSKHvDFKPAFKRLFKNTHYRFGVIAQF 259
Cdd:cd17394  161 LA-AMSAAELQAYKTAELASVQLPYLGIALVLLLLAVLILLSKLPE-IEAAEAEAL-GSKGTLLRLLKNPHLRLGVLAIF 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 260 FNVAAQTCVWTFTIQYVMEA-LNTNEVSGGTILQYSMITFLVSRFVMTWLMGFIRPAKLLMATSLIAMMLCIYMVQMPNI 338
Cdd:cd17394  238 FYVGAEVAIWSFLINYLMEYiAGLTETSAATFVSYYWGGFMVGRFLGTALLKKISPKKLLAVFALLGLLLLLGAIFTGGM 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 339 SGVWALVCISACLSLMFPTIYAIALHGLGDDAKLGAAGLVMAILGGAIVPVIQAVFI-DTYSVAFSYMVPAGCFIVVAAY 417
Cdd:cd17394  318 VALYALVLVGFFNSIMFPTIFSLALKGLGKHTKTGSGLLVMAIVGGAVVPLIQGAVAdDAAGLRIAFLVPLLCFAYILFY 397


                 .
gi 748714426 418 A 418
Cdd:cd17394  398 G 398
fucP TIGR00885
L-fucose:H+ symporter permease; This family describes the L-fucose permease in bacteria. ...
 17-418 4.64e-121

L-fucose:H+ symporter permease; This family describes the L-fucose permease in bacteria. L-fucose(6-deoxy-L-galactose) is a monosaccharide found in glycoproteins and cell wall polysaccharides. L-fucose is used in bacteria through an inducible pathway mediated by atleast four enzymes: a permease, isomerase, kinase and an aldolase which are encoded by fucP, fucI, fucK, fucA respectively. The fuc genes belong to a regulon comprising of four linked operons: fucO, fucA, fucPIK and fucR. The positive regulator is encoded by fucR, whose protein responds to fuculose-1-phosphate, which acts as an effector. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 211614  Cd Length: 408  Bit Score: 358.40  E-value: 4.64e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426   17 VVPFILLVLCFAAWGAAANMTDPLVKVFSKIFTMSSVQSALVQFSYYGAYFCLAIPAAYINKRFSYKVGVLTGLGMAAMG 96
Cdd:TIGR00885   2 IIPFALITSLFALWGFANDITNPMVPQFQQAFTLTAFQAALVQSAFYGGYFIMAIPAAIFMKKLSYKAGILLGLFLYALG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426   97 AFMFYPASQAMTYGFFLAALFILAGGLSILETSANPYVMGMGNEQSATRRLNLAQSFNPVGTNIGVFLAATLILPSLNTA 176
Cdd:TIGR00885  82 AFLFWPAAEIMNYTLFLVGLFILTAGLGFLETAANPYILVMGPESTATRRLNLAQSFNPFGSIIGMVVAQQLILSNLPHQ 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426  177 TSDERSSMTTSQLKNIISAELDAVMVPYVGMACVLVFIWLAIAFTKTPDFckKKQVSKHVDFKPAFKRLFKNTHYRFGVI 256
Cdd:TIGR00885 162 SQDVLDKLSPEELSAIKHSDLASVQTPYMIIGAVVLAVALLIMLTKMPAL--NHSDAKQISFSASLSRLARIRHYREGVI 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426  257 AQFFNVAAQTCVWTFTIQYVMEALNTNEVsgGTILQY---SMITFLVSRFVMTWLMGFIRPAKLLMATSLIAMMLCIYMV 333
Cdd:TIGR00885 240 AQFFYVGVQIMCWTFIIQYAVRLIPGMTA--GFAANYnigAMVIFFISRFIGTWLISYLAAHKVLMAYAIIGMALCLGSI 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426  334 QMPNISGVWALVCISACLSLMFPTIYAIALHGLGDDAKLGAAGLVMAILGGAIVPVIQAVFIDTYSVA------FSYMVP 407
Cdd:TIGR00885 318 FAGGHVGLYCLTLCSAFMSLMFPTIYGIALKGLGQDTKYGAAGLVMAIIGGGIVPPLQGFIIDMKEIAaapavnTSFILP 397

                         410
                  ....*....|.
gi 748714426  408 AGCFIVVAAYA 418
Cdd:TIGR00885 398 LLCFAVIFIYG 408
PRK10133 PRK10133
L-fucose:H+ symporter permease;
13-420 2.16e-80

L-fucose:H+ symporter permease;


Pssm-ID: 182260 [Multi-domain]  Cd Length: 438  Bit Score: 254.82  E-value: 2.16e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426  13 SKEMVVPFILLVLCFAAWGAAANMTDPLVKVFSKIFTMSSVQSALVQFSYYGAYFCLAIPAAYINKRFSYKVGVLTGLGM 92
Cdd:PRK10133  21 SRSYIIPFALLCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIITGLFL 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426  93 AAMGAFMFYPASQAMTYGFFLAALFILAGGLSILETSANPYVMGMGNEQSATRRLNLAQSFNPVGTNIGVFLAATLILPS 172
Cdd:PRK10133 101 YALGAALFWPAAEIMNYTLFLVGLFIIAAGLGCLETAANPFVTVLGPESSGHFRLNLAQTFNSFGAIIAVVFGQSLILSN 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 173 LNTATSDERSSMTTSQLKNIISAELDAVMVPYVGMACVLVFIWLAIAFTKTPDF-CKKKQVSKHVDFKPAFKRLFKNTHY 251
Cdd:PRK10133 181 VPHQSQDVLDKMTPEQLSAYKHSLVLSVQTPYMIIVAIVLLVALLIMLTKFPALqSDNHSDAKQGSFSASLSRLARIRHW 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 252 RFGVIAQFFNVAAQTCVWTFTIQYVMEAL-NTNEVSGGTILQYSMITFLVSRFVMTWLMGFIRPAKLLMATSLIAMMLCI 330
Cdd:PRK10133 261 RWAVLAQFCYVGAQTACWSYLIRYAVEEIpGMTAGFAANYLTGTMVCFFIGRFTGTWLISRFAPHKVLAAYALIAMALCL 340

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 331 YMVQMPNISGVWALVCISACLSLMFPTIYAIALHGLGDDAKLGAAGLVMAILGGAIV-PVIQAVFIDTYSVAFSYMVPAG 409
Cdd:PRK10133 341 ISAFAGGHVGLIALTLCSAFMSIQYPTIFSLGIKNLGQDTKYGSSFIVMTIIGGGIVtPVMGFVSDAAGNIPTAELIPAL 420

                        410
                 ....*....|.
gi 748714426 410 CFIVVAAYAAF 420
Cdd:PRK10133 421 CFAVIFIFARF 431
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
13-420 9.11e-77

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 243.99  E-value: 9.11e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426  13 SKEMVVPFILLVLCFAAWGAAANMTDPLVKVFSKIFTMSSVQSALVQFSYYGAYFCLAIPAAYINKRFSYKVGVLTGLGM 92
Cdd:COG0738    3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426  93 AAMGAFMFypaSQAMTYGFFLAALFILAGGLSILETSANPYVMGMGNEqSATRRLNLAQSFNPVGTNIGVFLAATLILPS 172
Cdd:COG0738   83 MALGLLLF---ALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPE-TAASRLNLLHAFFSLGALLGPLLGGLLILLG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 173 LNTAtsderssmttsqlkniisaeldaVMVPYVGMACVLVFIWLAIAFTKTPDFckKKQVSKHVDFKPAFKRLFKNTHYR 252
Cdd:COG0738  159 LSLS-----------------------WHLPYLILAVLLLLLALLFLRSKLPEI--EEEEEEAAGSAASLKSLLKNPRLL 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 253 FGVIAQFFNVAAQTCVWTFTIQYVMEALNTNEVSGGTILQYSMITFLVSRFVMTWLMGFIRPAKLLMATSLIAMMLCIYM 332
Cdd:COG0738  214 LGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLA 293

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 333 VQMPN-ISGVWALVCISACLSLMFPTIYAIALHGLGDD-AKLGAAGLVMAILGGAIVPVIQAVFIDTYSVAFSYMVPAGC 410
Cdd:COG0738  294 LLAPGpWLALIGLALVGLGLSLMFPTIFSLALDGLGKRtAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVC 373

                        410
                 ....*....|
gi 748714426 411 FIVVAAYAAF 420
Cdd:COG0738  374 YLLILLLALA 383
MFS_1 pfam07690
Major Facilitator Superfamily;
20-388 3.63e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 48.57  E-value: 3.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426   20 FILLVLCFAAWGAAANMtdpLVKVFSKIFTMSSVQSALVQFSYYGAYFCLAIPAAYINKRFSYKVGVLTGLGMAAMGAFM 99
Cdd:pfam07690   2 FLAAFLAALGRSLLGPA---LPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426  100 FYPASqamTYGFFLAALFILAGGLSILETSANPYVMGMGNEQSATRRLNLAQSFNPVGTNIGVFLAATLIlpslntATSD 179
Cdd:pfam07690  79 LLFAS---SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA------SLFG 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426  180 ERSSMttsqlkniisaeldAVMVPYVGMACVLVFIWLAIAFTKTPDFCKKKQVSKHVDFKPAFKRLFknthyrFGVIAQF 259
Cdd:pfam07690 150 WRAAF--------------LILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPV------LWLLLAL 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426  260 FNVAAQTCVWTFTIQYVMEALNTNEVSGGTILQYSMITFLVSRFVMTWLMGFIRPAKLLMATSLIAMMLCIYMVQMPNIS 339
Cdd:pfam07690 210 LLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTL 289

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 748714426  340 G----VWALVCISACLSLMFPTIYAIALHGLGDDAKLGAAGLVMAI--LGGAIVP 388
Cdd:pfam07690 290 SslwlLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAgsLGGALGP 344
 
Name Accession Description Interval E-value
MFS_FucP_like cd17394
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ...
 20-418 2.13e-131

Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340952 [Multi-domain]  Cd Length: 401  Bit Score: 384.27  E-value: 2.13e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426  20 FILLVLCFAAWGAAANMTDPLVKVFSKIFTMSSVQSALVQFSYYGAYFCLAIPAAYINKRFSYKVGVLTGLGMAAMGAFM 99
Cdd:cd17394    1 LALVTSLFFLWGFATNLNDILIPQFKNIFDLSNFQASLVQFAFFGAYFIMAIPAGMLIKRYGYKKGILLGLGLYAIGALL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 100 FYPASQAMTYGFFLAALFILAGGLSILETSANPYVMGMGNEQSATRRLNLAQSFNPVGTNIGVFLAATLILPSLNTATSD 179
Cdd:cd17394   81 FIPAASLRTYGLFLIALFVLASGLALLQTAANPYVTVLGPEETAARRLNLAQAFNSLGSTIAPLFGSYLILSGIPSTATA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 180 ERsSMTTSQLKNIISAELDAVMVPYVGMACVLVFIWLAIAFTKTPDfCKKKQVSKHvDFKPAFKRLFKNTHYRFGVIAQF 259
Cdd:cd17394  161 LA-AMSAAELQAYKTAELASVQLPYLGIALVLLLLAVLILLSKLPE-IEAAEAEAL-GSKGTLLRLLKNPHLRLGVLAIF 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 260 FNVAAQTCVWTFTIQYVMEA-LNTNEVSGGTILQYSMITFLVSRFVMTWLMGFIRPAKLLMATSLIAMMLCIYMVQMPNI 338
Cdd:cd17394  238 FYVGAEVAIWSFLINYLMEYiAGLTETSAATFVSYYWGGFMVGRFLGTALLKKISPKKLLAVFALLGLLLLLGAIFTGGM 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 339 SGVWALVCISACLSLMFPTIYAIALHGLGDDAKLGAAGLVMAILGGAIVPVIQAVFI-DTYSVAFSYMVPAGCFIVVAAY 417
Cdd:cd17394  318 VALYALVLVGFFNSIMFPTIFSLALKGLGKHTKTGSGLLVMAIVGGAVVPLIQGAVAdDAAGLRIAFLVPLLCFAYILFY 397


                 .
gi 748714426 418 A 418
Cdd:cd17394  398 G 398
fucP TIGR00885
L-fucose:H+ symporter permease; This family describes the L-fucose permease in bacteria. ...
 17-418 4.64e-121

L-fucose:H+ symporter permease; This family describes the L-fucose permease in bacteria. L-fucose(6-deoxy-L-galactose) is a monosaccharide found in glycoproteins and cell wall polysaccharides. L-fucose is used in bacteria through an inducible pathway mediated by atleast four enzymes: a permease, isomerase, kinase and an aldolase which are encoded by fucP, fucI, fucK, fucA respectively. The fuc genes belong to a regulon comprising of four linked operons: fucO, fucA, fucPIK and fucR. The positive regulator is encoded by fucR, whose protein responds to fuculose-1-phosphate, which acts as an effector. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 211614  Cd Length: 408  Bit Score: 358.40  E-value: 4.64e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426   17 VVPFILLVLCFAAWGAAANMTDPLVKVFSKIFTMSSVQSALVQFSYYGAYFCLAIPAAYINKRFSYKVGVLTGLGMAAMG 96
Cdd:TIGR00885   2 IIPFALITSLFALWGFANDITNPMVPQFQQAFTLTAFQAALVQSAFYGGYFIMAIPAAIFMKKLSYKAGILLGLFLYALG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426   97 AFMFYPASQAMTYGFFLAALFILAGGLSILETSANPYVMGMGNEQSATRRLNLAQSFNPVGTNIGVFLAATLILPSLNTA 176
Cdd:TIGR00885  82 AFLFWPAAEIMNYTLFLVGLFILTAGLGFLETAANPYILVMGPESTATRRLNLAQSFNPFGSIIGMVVAQQLILSNLPHQ 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426  177 TSDERSSMTTSQLKNIISAELDAVMVPYVGMACVLVFIWLAIAFTKTPDFckKKQVSKHVDFKPAFKRLFKNTHYRFGVI 256
Cdd:TIGR00885 162 SQDVLDKLSPEELSAIKHSDLASVQTPYMIIGAVVLAVALLIMLTKMPAL--NHSDAKQISFSASLSRLARIRHYREGVI 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426  257 AQFFNVAAQTCVWTFTIQYVMEALNTNEVsgGTILQY---SMITFLVSRFVMTWLMGFIRPAKLLMATSLIAMMLCIYMV 333
Cdd:TIGR00885 240 AQFFYVGVQIMCWTFIIQYAVRLIPGMTA--GFAANYnigAMVIFFISRFIGTWLISYLAAHKVLMAYAIIGMALCLGSI 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426  334 QMPNISGVWALVCISACLSLMFPTIYAIALHGLGDDAKLGAAGLVMAILGGAIVPVIQAVFIDTYSVA------FSYMVP 407
Cdd:TIGR00885 318 FAGGHVGLYCLTLCSAFMSLMFPTIYGIALKGLGQDTKYGAAGLVMAIIGGGIVPPLQGFIIDMKEIAaapavnTSFILP 397

                         410
                  ....*....|.
gi 748714426  408 AGCFIVVAAYA 418
Cdd:TIGR00885 398 LLCFAVIFIYG 408
PRK10133 PRK10133
L-fucose:H+ symporter permease;
13-420 2.16e-80

L-fucose:H+ symporter permease;


Pssm-ID: 182260 [Multi-domain]  Cd Length: 438  Bit Score: 254.82  E-value: 2.16e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426  13 SKEMVVPFILLVLCFAAWGAAANMTDPLVKVFSKIFTMSSVQSALVQFSYYGAYFCLAIPAAYINKRFSYKVGVLTGLGM 92
Cdd:PRK10133  21 SRSYIIPFALLCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIITGLFL 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426  93 AAMGAFMFYPASQAMTYGFFLAALFILAGGLSILETSANPYVMGMGNEQSATRRLNLAQSFNPVGTNIGVFLAATLILPS 172
Cdd:PRK10133 101 YALGAALFWPAAEIMNYTLFLVGLFIIAAGLGCLETAANPFVTVLGPESSGHFRLNLAQTFNSFGAIIAVVFGQSLILSN 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 173 LNTATSDERSSMTTSQLKNIISAELDAVMVPYVGMACVLVFIWLAIAFTKTPDF-CKKKQVSKHVDFKPAFKRLFKNTHY 251
Cdd:PRK10133 181 VPHQSQDVLDKMTPEQLSAYKHSLVLSVQTPYMIIVAIVLLVALLIMLTKFPALqSDNHSDAKQGSFSASLSRLARIRHW 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 252 RFGVIAQFFNVAAQTCVWTFTIQYVMEAL-NTNEVSGGTILQYSMITFLVSRFVMTWLMGFIRPAKLLMATSLIAMMLCI 330
Cdd:PRK10133 261 RWAVLAQFCYVGAQTACWSYLIRYAVEEIpGMTAGFAANYLTGTMVCFFIGRFTGTWLISRFAPHKVLAAYALIAMALCL 340

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 331 YMVQMPNISGVWALVCISACLSLMFPTIYAIALHGLGDDAKLGAAGLVMAILGGAIV-PVIQAVFIDTYSVAFSYMVPAG 409
Cdd:PRK10133 341 ISAFAGGHVGLIALTLCSAFMSIQYPTIFSLGIKNLGQDTKYGSSFIVMTIIGGGIVtPVMGFVSDAAGNIPTAELIPAL 420

                        410
                 ....*....|.
gi 748714426 410 CFIVVAAYAAF 420
Cdd:PRK10133 421 CFAVIFIFARF 431
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
13-420 9.11e-77

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 243.99  E-value: 9.11e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426  13 SKEMVVPFILLVLCFAAWGAAANMTDPLVKVFSKIFTMSSVQSALVQFSYYGAYFCLAIPAAYINKRFSYKVGVLTGLGM 92
Cdd:COG0738    3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426  93 AAMGAFMFypaSQAMTYGFFLAALFILAGGLSILETSANPYVMGMGNEqSATRRLNLAQSFNPVGTNIGVFLAATLILPS 172
Cdd:COG0738   83 MALGLLLF---ALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPE-TAASRLNLLHAFFSLGALLGPLLGGLLILLG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 173 LNTAtsderssmttsqlkniisaeldaVMVPYVGMACVLVFIWLAIAFTKTPDFckKKQVSKHVDFKPAFKRLFKNTHYR 252
Cdd:COG0738  159 LSLS-----------------------WHLPYLILAVLLLLLALLFLRSKLPEI--EEEEEEAAGSAASLKSLLKNPRLL 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 253 FGVIAQFFNVAAQTCVWTFTIQYVMEALNTNEVSGGTILQYSMITFLVSRFVMTWLMGFIRPAKLLMATSLIAMMLCIYM 332
Cdd:COG0738  214 LGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLA 293

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 333 VQMPN-ISGVWALVCISACLSLMFPTIYAIALHGLGDD-AKLGAAGLVMAILGGAIVPVIQAVFIDTYSVAFSYMVPAGC 410
Cdd:COG0738  294 LLAPGpWLALIGLALVGLGLSLMFPTIFSLALDGLGKRtAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVC 373

                        410
                 ....*....|
gi 748714426 411 FIVVAAYAAF 420
Cdd:COG0738  374 YLLILLLALA 383
gluP TIGR01272
glucose/galactose transporter; This model describes the glucose/galactose transporter in ...
 100-417 9.05e-38

glucose/galactose transporter; This model describes the glucose/galactose transporter in bacteria. This belongs to the larger facilitator superfamily. Disruption of the loci leads to the total loss of glucose or galactose uptake in E.coli. Putative transporters in other bacterial species were isolated by functional complementation, which restored it functional activity. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273531 [Multi-domain]  Cd Length: 310  Bit Score: 139.26  E-value: 9.05e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426  100 FYPASQAMTYGFFLAALFILAGGLSILETSANPYVMGMGNEQSATRRLNLAQSFNPVGTNIGVFLAATLILpslnTATSD 179
Cdd:TIGR01272   1 FGPAASQRYYVLFLGALFVLASGLTILQVAANPYVSILGPIETAASRLALTQAFNKLGTTVAPLFGGSLIL----SGAGD 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426  180 ERSSMTTsqlkniISAELDAVMVPYVGMACVLVFIWLAIAFTKTPDFCKKKQVSKHVDFKPAFKRLFKNTHYRFGVIAQF 259
Cdd:TIGR01272  77 LSMQVAT------ANAEAAKVHTPYLLLAGALAVLAIIFAFLPLPELQEADVARVSSGDTTQKTSAFQFTHLVLGALGIF 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426  260 FNVAAQTCVWTFTIQYVME--ALNTNEVSGGTILQYSMITFLVSRFVMTWLMGFIRPAKLLMATSLIAMMLCIYMVQMPN 337
Cdd:TIGR01272 151 VYVGAEVSAGSFLVNFLSDphALGLPEDQAAHFTAYTWGGAMVGRFIGSAVMPMISQGRYLAFNAFLAVLLSIGAALTHG 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426  338 ISGVWALVCISACLSLMFPTIYAIALHGLGDDAKLGAAGLVMAILGGAIVPVIQAVFIDTYSVAFSYMVPAGCFIVVAAY 417
Cdd:TIGR01272 231 YVAMWFVLALGLFNSIMFPTIFSLALNALGRHTSQGSGILCLAIVGGAIVPLLQGSLADCLGIQLAFALPVPCYLYILFY 310
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 25-415 1.16e-27

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 112.80  E-value: 1.16e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426  25 LCFAAWGAAANMTDPLVKVFSKIFTMSSVQSALVQFSYYGAYFCLAIPAAYINKRFSYKVGVLTGLGMAAMGAFMFYPAS 104
Cdd:cd17333    3 ISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATP 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 105 QamtYGFFLAALFILAGGLSILETSANPYVMGMGNEQSATRrLNLAQSFNPVGTNIGVFLAATLILPSLNtatsderssm 184
Cdd:cd17333   83 S---IYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATR-LNVLHGFFGLGALIGPLIATSLLTSELS---------- 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 185 ttsqlkniisaeldaVMVPYVGMACVLVFIWLAIAFTKTPDFCKKK-QVSKHVDFKPAFKRLFKNTHYRFGVIAQFFNVA 263
Cdd:cd17333  149 ---------------WSWAYLIIGLIYLLLAILILLTLFPELPSARnPQQSVGAFSASASRLLRNPSIILGALALFLYVG 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 264 AQTCVWTFTIQYVMEALNTNEVSGGTILQYSMITFLVSRFVMTWLMGFIRPAKLLMATSLIAMMLCIYMVQMPN-ISGVW 342
Cdd:cd17333  214 AETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTlVVGLV 293

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 748714426 343 ALVCISACLSLMFPTIYAIALHGLGD-DAKLGAAGLVMAILGGAIVPVIQAVFIDTYSVAFSYMVPAGCFIVVA 415
Cdd:cd17333  294 ATALLGLFMAALFPTILSLGISNLPYaKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIF 367
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 23-415 6.11e-17

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 82.09  E-value: 6.11e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426  23 LVLCFAAWGAAANMTDPLVKVFSKIFTMSSVQSALVQFSYYGAYFCLAIPAAYINKRFSYKVGVLTGLGMAAMGAFMFYP 102
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 103 ASQamtYGFFLAALFILAGGLSILETSANPYVMGMGNEQSATRRLNLAQSFNPVGTNIGVFLAATLILpslntatsders 182
Cdd:cd06174   81 APS---FWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAS------------ 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 183 smttsqlknIISAELDAVMVPYVGMACVLVFIWLAIAFTKTPDFCKKKQVSKHVDFKPAFKRLFKNTHYRFGVIAQFFNV 262
Cdd:cd06174  146 ---------SLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVN 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 263 AAQTCVWTFTIQYVMEALNTNEVSGGTILQYSMITFLVSRFVMTWLMGFIRPAKLLMATSLIAMMLC--IYMVQMPNISG 340
Cdd:cd06174  217 LAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGlaLLLLAPSLLLL 296

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 748714426 341 VWALVCISACLSLMFPTIYAIALHGLGDDAKLGAAGLVMAI--LGGAIVPVIQAVFID-TYSVAFSYMVPAGCFIVVA 415
Cdd:cd06174  297 LLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFgfLGGAIGPLLAGFLLAaTFGLTGAFLVLAVLLLLAA 374
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
10-386 4.08e-12

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 66.92  E-value: 4.08e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426  10 PLVSKEMVVPFILLVLCFAAWGAAANMTDPLVKVFSKIFTMSSVQSALVQFSYYGAYFCLAIPAAYINKRFSYKVGVLTG 89
Cdd:COG2814    2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426  90 LGMAAMGAFMfypASQAMTYGFFLAALFILAGGLSILETSANPYVMGMGNEQSATRRLNLAQSFNPVGTNIGVFLAATLi 169
Cdd:COG2814   82 LLLFALGSLL---CALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLL- 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 170 lpslntatsderssmttsqlkniisAELDAVMVPYVGMACVLVFIWLAIAFtktpdFCKKKQVSKHVDFKPAFKRLFKNT 249
Cdd:COG2814  158 -------------------------ADLFGWRWVFLVNAVLALLALLLLLR-----LLPESRPAARARLRGSLRELLRRP 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 250 HYRFGVIAQFFNVAAQTCVWTFTIQYVMEALNTNEVSGGTILQYSMITFLVSRFVMTWLMGFIRPAKLLMATSLIAMMLC 329
Cdd:COG2814  208 RLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGL 287

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 748714426 330 IYMVQMPNISGVWALVCI-SACLSLMFPTIYAIALHGLGDDAKLGAAGLVMAILGGAI 386
Cdd:COG2814  288 LLLALAGSLWLLLLALFLlGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 23-420 1.48e-09

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 59.51  E-value: 1.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426  23 LVLCFAAWGAAANMTDPLVKVFSKIFTMSSVQSALVQFSYYGAYFCLAIPAAYINKRFSYKVGVLTGLGMAAMGAFMFyp 102
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLF-- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 103 aSQAMTYGFFLAALFILAGGLSILETSANPYVMGMGNEQSATRRLNLAQSFNPVGTNIGVFLAAtlilpslntatsders 182
Cdd:cd17325   79 -AFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGG---------------- 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 183 smttsqlknIISAELDAVMVPYVGMACVLVFIWLAIAFTKTPDFCKKKQVSKHVDFKPAFKRLFKNTHYRFGVIAQFFNV 262
Cdd:cd17325  142 ---------LLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLA 212

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 263 AAQTCVWTFTIQYVMEALNTNEVSGGTILQYSMITFLVSRFVMTWLMgFIRPAKLLMATSLIAMMLCIYMV-QMPNISGV 341
Cdd:cd17325  213 FAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLS-DRIGRKPLILIGLLLSAVALLLLpLATSFWLL 291

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 342 WAL-VCISACLSLMFPTIYAIalhgLGDDAKLGAAGLVMAI------LGGAIVPVIQAVFIDTYSVAFSYMVPAGCFIVV 414
Cdd:cd17325  292 LLLlALLGLGLGLVFPATLAL----LADIVPPEGRGTAMGLfntafsLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLA 367


                 ....*.
gi 748714426 415 AAYAAF 420
Cdd:cd17325  368 AVLFLL 373
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
85-361 5.28e-09

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 57.99  E-value: 5.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426  85 GVLTGLGMAAMgaFMFYPASQAMTYGFFLAALFILAGGLSILETsanPYVmGMGNEQSATRRL-NLAQSFNPVGTNIGVF 163
Cdd:COG2211   88 AIPLALSFVLL--FTAPDLSPTGKLIYALVTYLLLGLAYTLVNI---PYS-ALGAELTPDYEErTRLSSWRFAFAGLGGL 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 164 LAATLILPSLNTATSDERSSMTtsqlkniisaeldavMVPYVGMACVLVFIWLAIAFTKTPDFCKKKQVSkhvdFKPAFK 243
Cdd:COG2211  162 LASVLPPPLVAAFGGDAALGYR---------------LTALIFAVLGLLAFLLTFFGTKERPVPEEEKVS----LKESLK 222

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 244 RLFKNTHYRFGVIAQFFNVAAQTCVWTFTIQYVMEALNTNEVSGGTILQYSMITFLVSRFVMTWLMGFIRPAKLLMATSL 323
Cdd:COG2211  223 ALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLL 302

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 748714426 324 --IAMMLCIYMVQMPNISGVWALVCIS-ACLSLMFPTIYAI 361
Cdd:COG2211  303 laALGLLLLFFLGPGNLWLLLVLAALAgIGLGAILVLPWAM 343
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
20-428 1.79e-07

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 52.96  E-value: 1.79e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426  20 FILLVLCFAAWGAAAnmtdPLVKVFSKIFTMSSVQSALVQFSYYGAYFCLAIPAAYINKRFSYKVGVLTGLGMAAMGAFM 99
Cdd:COG2223   11 TLAFFLAFGVWYLWS----VLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 100 fypASQAMTYGFFLAALFILAGGLSILETSANPYVMGMgneqSATRRLNLAQSFNPVGTNIGVFLAATLILPSLNTatsd 179
Cdd:COG2223   87 ---LALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKW----FPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAA---- 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 180 erssmttsqlkniisaeLDAVMVPYVGMACVLVFIWLAIAFTKTPDfcKKKQVSKHVDFKpAFKRLFKNTHYRFGVIAQF 259
Cdd:COG2223  156 -----------------FGWRNAFLILGILLLVVAVLAWLFLRDPP--AGAAAAAKASLR-DQLEALRDPRFWLLSLLYF 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 260 FNVAAQTCVWTFTIQYVMEALNTNEVSGGTILQYSMITFLVSRFVMTWLMGFIRPAKLLMATSLIAMMLCIYMVQMPN-- 337
Cdd:COG2223  216 GTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGsl 295

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 338 ISGVWALVCISACLSLMFPTIYAIALHGLGDDAKLGAAGLVMAI--LGGAIVPVIQAVFIDTYSVAFSYMVPAGCFIVVA 415
Cdd:COG2223  296 WLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAggLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVA 375

                        410
                 ....*....|...
gi 748714426 416 AYAAFDLKAKVRT 428
Cdd:COG2223  376 LVLTLLLYRRPRR 388
MFS_1 pfam07690
Major Facilitator Superfamily;
20-388 3.63e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 48.57  E-value: 3.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426   20 FILLVLCFAAWGAAANMtdpLVKVFSKIFTMSSVQSALVQFSYYGAYFCLAIPAAYINKRFSYKVGVLTGLGMAAMGAFM 99
Cdd:pfam07690   2 FLAAFLAALGRSLLGPA---LPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426  100 FYPASqamTYGFFLAALFILAGGLSILETSANPYVMGMGNEQSATRRLNLAQSFNPVGTNIGVFLAATLIlpslntATSD 179
Cdd:pfam07690  79 LLFAS---SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA------SLFG 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426  180 ERSSMttsqlkniisaeldAVMVPYVGMACVLVFIWLAIAFTKTPDFCKKKQVSKHVDFKPAFKRLFknthyrFGVIAQF 259
Cdd:pfam07690 150 WRAAF--------------LILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPV------LWLLLAL 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426  260 FNVAAQTCVWTFTIQYVMEALNTNEVSGGTILQYSMITFLVSRFVMTWLMGFIRPAKLLMATSLIAMMLCIYMVQMPNIS 339
Cdd:pfam07690 210 LLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTL 289

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 748714426  340 G----VWALVCISACLSLMFPTIYAIALHGLGDDAKLGAAGLVMAI--LGGAIVP 388
Cdd:pfam07690 290 SslwlLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAgsLGGALGP 344
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
20-420 8.94e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 47.56  E-value: 8.94e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426  20 FILLVLCFAAWGAAANMTDPLVKVFSKIFTMSSVQSALVQFSYYGAYFCLAIPAAYINKRFSYKVGVLTGLGMAAMGAFM 99
Cdd:COG2271   12 LALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 100 FypaSQAMTYGFFLAALFILAGGLSILETSANPYVmgmgNEQSATRRLNLAQSFNPVGTNIGVFLAATLIlpslntatsd 179
Cdd:COG2271   92 F---GFATSFWQLLLLRFLLGLGEAGFFPAALKLI----AEWFPPKERGRALGIFNAGGPLGGALAPPLL---------- 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 180 erssmttsqlkniisaeldAVMVPYVG------MACVLVFIWLAIAFtktpdfckkkqvskhvdfkpafkrlfknthyRF 253
Cdd:COG2271  155 -------------------GWLLAAFGwraaflILGLPGLLLALLRF-------------------------------WL 184

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 254 GVIAQFFNVAAQTCVWTFTIQYVMEALNTNEVSGGTILQYSMITFLVSRFVMTWLMG-FIRPAKLLMATSLIAMMLCIYM 332
Cdd:COG2271  185 LALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDrLGRRRKLVLAIGLLLAALALLL 264

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 333 VQM--PNISGVWALVCISACLSLMFPTIYAIALHGLGDDAKLGAAGLVMAI--LGGAIVPVIQAVFIDTYSVAFSYMVPA 408
Cdd:COG2271  265 LALlpSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFgfLGGALGPLLVGYLLDATGYQAAFLLLA 344

                        410
                 ....*....|..
gi 748714426 409 GCFIVVAAYAAF 420
Cdd:COG2271  345 ALALLAALLALL 356
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 22-416 1.75e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 43.31  E-value: 1.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426  22 LLVLCFAAWGAAAN--MTDPLVKVFSKIFTMSSVQSALVQFSYYGAYFCLAIPAAYINKRFSYKVGVLTGLGMAAMGAFM 99
Cdd:cd17324    1 LLALALAAFAIGTTeyVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 100 fypASQAMTYGFFLAALFILAGGLSILETSANPYVMGMGNEQSATRRLNLAQSFNPVGTNIGVFLAAtlilpslntatsd 179
Cdd:cd17324   81 ---AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGG------------- 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 180 erssmttsqlknIISAELDAVMVPY-VGMACVLVFIWLAIAFTKTPDFckkkqVSKHVDFKPAFKRLFKNTHYRFGVIAQ 258
Cdd:cd17324  145 ------------LLGQLLGWRAAFLaIAVLALLAALLLWRLLPSLPPK-----KPGSLGLLSSLLLLLRNPRLRLAYLIT 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 259 FFNVAAQTCVWTFTIQYVME-ALNTNEVSGGTILQYSMITFLVSRFVMTWLMGFIRPAKLLMATSLIAMMLCIYMVQMPN 337
Cdd:cd17324  208 FLLFGGFFALYTYLAPFLTDvPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSP 287

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 338 ISGVWALVCISACLSLMFPTIYAIALHgLGDDAKLGAAGLVMAI--LGGAIVPVIQAVFIDTYSVAfsyMVPAGCFIVVA 415
Cdd:cd17324  288 LLLLVGLVLWGLGFFAAHSALQTRVLR-LAPEARGLASSLYLAAynLGGALGAALGGLVLDHGGWA---GVGWVGAALLL 363


                 .
gi 748714426 416 A 416
Cdd:cd17324  364 L 364
MFS_1 pfam07690
Major Facilitator Superfamily;
19-161 9.01e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 41.25  E-value: 9.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426   19 PFILLVLCFAAWGAAANMTDPLVKVFSKIFTMSSVQSALVQFSYYGAYFCLAIPAAYINKRFSYKVGVLTGLGMAAMGAF 98
Cdd:pfam07690 201 PVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAAL 280

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 748714426   99 MFYPASQAMTYGFFLAALFILAGGLSILETSANPYVMGMGNEQSATRRLNLAQSFNPVGTNIG 161
Cdd:pfam07690 281 GLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 89-416 1.72e-03

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 40.30  E-value: 1.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426  89 GLGMAAMGAfMFYPASQAMTYGFFLAALFILAGGLSILETSANPYVMGMGNEqsatRRLNLAQSFNPVGTNIGVFLAAtL 168
Cdd:cd17475   65 AVGLLLMGA-AALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPP----RERGLAMGIRQTGVPLGGALAA-A 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 169 ILPSLNTATSdERSSMTTSQLKNIISAeldavmvpyvgmacVLVFIWlaiaFTKTPDFCKKKQVSKHVdfKPAFKRLFKN 248
Cdd:cd17475  139 LLPPLALHYG-WRAAFVVAGLVSILAA--------------VLFWLF----YREPPAASAATESASTL--LRSLKEVLRN 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 249 THYRFGVIAQFFNVAAQTCVWTFTIQYVMEALNTNEVSGGTILQYSMITFLVSRFVMTWL---MGFIRPAKLLMATSLIA 325
Cdd:cd17475  198 RDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVsdrVFGGRRRPVLVITAAIA 277

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 326 MMLCIYMVQMPNISGVWALVCISACLSLMFPTIYAIALHGLGDDAKLGAAGLVMAI------LGGAIVPVIQAVFID-TY 398
Cdd:cd17475  278 AAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLantinfIGIAIGPPLFGLLVDaTH 357

                        330
                 ....*....|....*...
gi 748714426 399 SVAFSYMVPAGCFIVVAA 416
Cdd:cd17475  358 SYAPAWLALALLLVLAAL 375
MFS_1 pfam07690
Major Facilitator Superfamily;
256-434 2.96e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 39.71  E-value: 2.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426  256 IAQFFNVAAQTCVWTFTIQYVMEALNTNEVSGGTILQYSMITFLVSRFVMTWLMGFIRPAKLLMATSLIAMMLCIYMVQM 335
Cdd:pfam07690   3 LAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426  336 PNISGVWAL-VCISACLSLMFPTIYAIALHGLGDDAKLGAAGLVMAI--LGGAIVPVIQAVFIDTYSVAFSYMVPAGCFI 412
Cdd:pfam07690  83 SSLWLLLVLrVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGfgLGAALGPLLGGLLASLFGWRAAFLILAILSL 162

                         170       180
                  ....*....|....*....|..
gi 748714426  413 VVAAYAAFDLKAKVRTFNKTSP 434
Cdd:pfam07690 163 LAAVLLLLPRPPPESKRPKPAE 184
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
1-419 5.56e-03

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 38.70  E-value: 5.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426   1 MTTHTHTKAPLVSKEMVVPFILLVLCFAAWGAAANMTDPLVKVFSKIFTMSSVQSALVQFSYYGAYFCLAIPAAYINKRF 80
Cdd:COG2807    1 MSTTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426  81 SYKVGVLTGLGMAAMGAFMFYPASQamTYGFFLAALFILAGglsiletsanpyvMGMGN-------EQSATRRLNLAQSF 153
Cdd:COG2807   81 GLERTLLLALLLLAAGLLLRSLAPS--VALLLAGTALIGAG-------------IAVGNvllpgliKRWFPDRVGLMTGL 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 154 NPVGTNIGVFLAATLILPsLNTATSderssmttsqlkniISAELDAVMVPyvgmACVLVFIWLAIAFTKTPDfckkkqvS 233
Cdd:COG2807  146 YTAAMGLGAALAAGLTVP-LAAALG--------------WRGALAVWALL----ALLALLLWLPLLRRRPAA-------A 199

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 234 KHVDFKPAFKRLFKNTHYRFGVIAQFFNVAAQTCVWTFTIQYVMEAlNTNEVSGGTILQYSMITFLVSRFVMTWLMGFIR 313
Cdd:COG2807  200 AAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDA-GLSAATAGLLLSLFQLAGIPGSLLVPLLADRLG 278

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748714426 314 PAKLLMATSLIAMML-CIYMVQMPNISGVWALVCISACLSLMFPTIYAIALHGLGDDAKLGAA-GLVMAI--LGGAIVPV 389
Cdd:COG2807  279 DRRPLLLLLGLLGLAgLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAALsGMAQSVgyLLAALGPL 358

                        410       420       430
                 ....*....|....*....|....*....|...
gi 748714426 390 IQAVFID---TYSVAFSYMVPAGCFIVVAAYAA 419
Cdd:COG2807  359 LVGALHDatgSWTAALLLLAALAVLMLVAGLLA 391
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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