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Conserved domains on  [gi|74762781|sp|Q9UM44|]
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RecName: Full=HERV-H LTR-associating protein 2; AltName: Full=Human endogenous retrovirus-H long terminal repeat-associating protein 2; Flags: Precursor

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_HHLA2 cd16091
Immunoglobulin Variable (IgV) domain in HERV-H LTR-associating 2 (HHLA2); The members here are ...
 33-138 2.39e-56

Immunoglobulin Variable (IgV) domain in HERV-H LTR-associating 2 (HHLA2); The members here are composed of the immunoglobulin variable (IgV) region in HERV-H LTR-associating 2 (HHLA2; also known as B7-H7/B7 homolog 7). HHLA2 is a member of the B7 family of immune regulatory proteins. Mature human HHLA2 consists of an extracellular domain (ECD) with three immunoglobulin-like domains, a transmembrane segment, and a cytoplasmic domain. HHLA2 is widely expressed in human cancers including non-small cell lung carcinoma (NSCLS), triple negative breast cancer (TNBC), and melanoma, but has limited expression on normal tissues. Interestingly, unlike other members of B7 family, HHLA2 is not expressed in mice or rats. HHLA2 functions as a T cell coinhibitory molecules as it inhibits the proliferation of activated CD4(+) and CD8(+) T cells and their cytokine production. Furthermore, HHLA2 is constitutively expressed on the surface of human monocytes and is induced on B cells after stimulation, however it is not inducible on T cells.


:

Pssm-ID: 409512  Cd Length: 107  Bit Score: 180.66  E-value: 2.39e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762781  33 PMNEQIVIGRLDEDIILPSSFERGSEVVIHWKYQDS-YKVHSYYKGSDHLESQDPRYANRTSLFYNEIQNGNASLFFRRV 111
Cdd:cd16091   1 AVSEVIVVCLLSEDCILPCSFTPGSEVVIHWYKQDSdIKVHSYYYGKDQLESQDQRYRNRTSLFKDQISNGNASLLLRRV 80

                        90       100
                ....*....|....*....|....*..
gi 74762781 112 SLLDEGIYTCYVGTAIQVITNKVVLKV 138
Cdd:cd16091  81 QLQDEGRYKCYTSTIIGNQESFVNLKV 107
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 231-330 2.11e-15

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


:

Pssm-ID: 462230  Cd Length: 109  Bit Score: 71.72  E-value: 2.11e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762781   231 LHKMQSEHVSLSCQpvNDYFSPNQDFKVTWSRMKSG--TFSVLAYYlSSSQNTIINESRFSWNKeLINQSDFSMNLMDLN 308
Cdd:pfam07686   6 VTVALGGSVTLPCT--YSSSMSEASTSVYWYRQPPGkgPTFLIAYY-SNGSEEGVKKGRFSGRG-DPSNGDGSLTIQNLT 81

                          90       100
                  ....*....|....*....|....*...
gi 74762781   309 LSDSGEYLCNISSDEY------TLLTIH 330
Cdd:pfam07686  82 LSDSGTYTCAVIPSGEgvfgkgTRLTVL 109
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 140-220 1.26e-05

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd00098:

Pssm-ID: 472250  Cd Length: 95  Bit Score: 43.60  E-value: 1.26e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762781 140 VFLTPVMKYEKRNTNSFLICSVLSVYPRPI-ITWKMDNTPISENNMEETGSL---DSFSINSPLNIT----GSNSSYECT 211
Cdd:cd00098   2 VTLLPPSPEEKGGGKVTLVCLVSGFYPKDItVTWLKNGVPLTSGVSTSSPVEpndGTYSVTSSLTVPpsdwDEGATYTCV 81


                ....*....
gi 74762781 212 IENSLLKQT 220
Cdd:cd00098  82 VTHESLKSP 90
 
Name Accession Description Interval E-value
IgV_HHLA2 cd16091
Immunoglobulin Variable (IgV) domain in HERV-H LTR-associating 2 (HHLA2); The members here are ...
 33-138 2.39e-56

Immunoglobulin Variable (IgV) domain in HERV-H LTR-associating 2 (HHLA2); The members here are composed of the immunoglobulin variable (IgV) region in HERV-H LTR-associating 2 (HHLA2; also known as B7-H7/B7 homolog 7). HHLA2 is a member of the B7 family of immune regulatory proteins. Mature human HHLA2 consists of an extracellular domain (ECD) with three immunoglobulin-like domains, a transmembrane segment, and a cytoplasmic domain. HHLA2 is widely expressed in human cancers including non-small cell lung carcinoma (NSCLS), triple negative breast cancer (TNBC), and melanoma, but has limited expression on normal tissues. Interestingly, unlike other members of B7 family, HHLA2 is not expressed in mice or rats. HHLA2 functions as a T cell coinhibitory molecules as it inhibits the proliferation of activated CD4(+) and CD8(+) T cells and their cytokine production. Furthermore, HHLA2 is constitutively expressed on the surface of human monocytes and is induced on B cells after stimulation, however it is not inducible on T cells.


Pssm-ID: 409512  Cd Length: 107  Bit Score: 180.66  E-value: 2.39e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762781  33 PMNEQIVIGRLDEDIILPSSFERGSEVVIHWKYQDS-YKVHSYYKGSDHLESQDPRYANRTSLFYNEIQNGNASLFFRRV 111
Cdd:cd16091   1 AVSEVIVVCLLSEDCILPCSFTPGSEVVIHWYKQDSdIKVHSYYYGKDQLESQDQRYRNRTSLFKDQISNGNASLLLRRV 80

                        90       100
                ....*....|....*....|....*..
gi 74762781 112 SLLDEGIYTCYVGTAIQVITNKVVLKV 138
Cdd:cd16091  81 QLQDEGRYKCYTSTIIGNQESFVNLKV 107
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 231-330 2.11e-15

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 71.72  E-value: 2.11e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762781   231 LHKMQSEHVSLSCQpvNDYFSPNQDFKVTWSRMKSG--TFSVLAYYlSSSQNTIINESRFSWNKeLINQSDFSMNLMDLN 308
Cdd:pfam07686   6 VTVALGGSVTLPCT--YSSSMSEASTSVYWYRQPPGkgPTFLIAYY-SNGSEEGVKKGRFSGRG-DPSNGDGSLTIQNLT 81

                          90       100
                  ....*....|....*....|....*...
gi 74762781   309 LSDSGEYLCNISSDEY------TLLTIH 330
Cdd:pfam07686  82 LSDSGTYTCAVIPSGEgvfgkgTRLTVL 109
IGv smart00406
Immunoglobulin V-Type;
239-317 3.20e-07

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 47.76  E-value: 3.20e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762781    239 VSLSCQpvndyFSPNQ--DFKVTWSRMKSGTFSVLAYYLSSSQNTIINES---RFSWNKELiNQSDFSMNLMDLNLSDSG 313
Cdd:smart00406   2 VTLSCK-----FSGSTfsSYYVSWVRQPPGKGLEWLGYIGSNGSSYYQESykgRFTISKDT-SKNDVSLTISNLRVEDTG 75


                   ....
gi 74762781    314 EYLC 317
Cdd:smart00406  76 TYYC 79
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 39-138 9.74e-07

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 47.07  E-value: 9.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762781    39 VIGRLDEDIILP---SSFERGSEVVIHWKYQDSYKVHS----YYKGSDHLESQDPRYANRTSlfyneIQNGNASLFFRRV 111
Cdd:pfam07686   6 VTVALGGSVTLPctySSSMSEASTSVYWYRQPPGKGPTfliaYYSNGSEEGVKKGRFSGRGD-----PSNGDGSLTIQNL 80

                          90       100
                  ....*....|....*....|....*...
gi 74762781   112 SLLDEGIYTCYVGTA-IQVITNKVVLKV 138
Cdd:pfam07686  81 TLSDSGTYTCAVIPSgEGVFGKGTRLTV 108
IgC1 cd00098
Immunoglobulin Constant-1 (C1)-set domain; The members here are composed of C1-set domains, ...
 140-220 1.26e-05

Immunoglobulin Constant-1 (C1)-set domain; The members here are composed of C1-set domains, classical Ig-like domains resembling the antibody constant domain. Members of the IgC1 family are components of immunoglobulin, T-cell receptors, CD1 cell surface glycoproteins, secretory glycoproteins A/C, and major histocompatibility complex (MHC) class I/II molecules. In immunoglobulins, each chain is composed of one variable domain (IgV) and one or more IgC domains. These names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. The IgV domain is responsible for antigen binding, while the IgC domain is involved in oligomerization and molecular interactions. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other strands by G, F, C, and C'.


Pssm-ID: 409354  Cd Length: 95  Bit Score: 43.60  E-value: 1.26e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762781 140 VFLTPVMKYEKRNTNSFLICSVLSVYPRPI-ITWKMDNTPISENNMEETGSL---DSFSINSPLNIT----GSNSSYECT 211
Cdd:cd00098   2 VTLLPPSPEEKGGGKVTLVCLVSGFYPKDItVTWLKNGVPLTSGVSTSSPVEpndGTYSVTSSLTVPpsdwDEGATYTCV 81


                ....*....
gi 74762781 212 IENSLLKQT 220
Cdd:cd00098  82 VTHESLKSP 90
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 231-325 8.67e-05

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 41.55  E-value: 8.67e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762781 231 LHKMQSEHVSLSCQpvndYFSPNQDFKVTWSRMKSGTFSVLAYYLSSSQNTIIN--ESRFSWNKELinQSDFSMNLMDLN 308
Cdd:cd00099   8 LSVQEGESVTLSCE----VSSSFSSTYIYWYRQKPGQGPEFLIYLSSSKGKTKGgvPGRFSGSRDG--TSSFSLTISNLQ 81

                        90       100
                ....*....|....*....|.
gi 74762781 309 LSDSGEYLC----NISSDEYT 325
Cdd:cd00099  82 PEDSGTYYCavseSGGTDKLT 102
C1-set pfam07654
Immunoglobulin C1-set domain;
140-214 3.08e-04

Immunoglobulin C1-set domain;


Pssm-ID: 462221  Cd Length: 85  Bit Score: 39.16  E-value: 3.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762781   140 VFLTPVMKYEKRNTNSfLICSVLSVYPRPI-ITWKMDNTPISENNMEETGSLD---SFSINSPLNITGSN----SSYECT 211
Cdd:pfam07654   1 VYVFPPSPEELGKPNT-LTCLVTGFYPPDItVTWLKNGQEVTEGVKTTPPSPNsdwTYQLSSYLTVTPSDwesgDEYTCR 79


                  ...
gi 74762781   212 IEN 214
Cdd:pfam07654  80 VEH 82
 
Name Accession Description Interval E-value
IgV_HHLA2 cd16091
Immunoglobulin Variable (IgV) domain in HERV-H LTR-associating 2 (HHLA2); The members here are ...
 33-138 2.39e-56

Immunoglobulin Variable (IgV) domain in HERV-H LTR-associating 2 (HHLA2); The members here are composed of the immunoglobulin variable (IgV) region in HERV-H LTR-associating 2 (HHLA2; also known as B7-H7/B7 homolog 7). HHLA2 is a member of the B7 family of immune regulatory proteins. Mature human HHLA2 consists of an extracellular domain (ECD) with three immunoglobulin-like domains, a transmembrane segment, and a cytoplasmic domain. HHLA2 is widely expressed in human cancers including non-small cell lung carcinoma (NSCLS), triple negative breast cancer (TNBC), and melanoma, but has limited expression on normal tissues. Interestingly, unlike other members of B7 family, HHLA2 is not expressed in mice or rats. HHLA2 functions as a T cell coinhibitory molecules as it inhibits the proliferation of activated CD4(+) and CD8(+) T cells and their cytokine production. Furthermore, HHLA2 is constitutively expressed on the surface of human monocytes and is induced on B cells after stimulation, however it is not inducible on T cells.


Pssm-ID: 409512  Cd Length: 107  Bit Score: 180.66  E-value: 2.39e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762781  33 PMNEQIVIGRLDEDIILPSSFERGSEVVIHWKYQDS-YKVHSYYKGSDHLESQDPRYANRTSLFYNEIQNGNASLFFRRV 111
Cdd:cd16091   1 AVSEVIVVCLLSEDCILPCSFTPGSEVVIHWYKQDSdIKVHSYYYGKDQLESQDQRYRNRTSLFKDQISNGNASLLLRRV 80

                        90       100
                ....*....|....*....|....*..
gi 74762781 112 SLLDEGIYTCYVGTAIQVITNKVVLKV 138
Cdd:cd16091  81 QLQDEGRYKCYTSTIIGNQESFVNLKV 107
IgV_B7-H3 cd20934
Immunoglobulin Variable (IgV) domain of B7-H3, a member of the B7 family of immune checkpoint ...
 36-123 6.29e-21

Immunoglobulin Variable (IgV) domain of B7-H3, a member of the B7 family of immune checkpoint molecules; The members here are composed of the immunoglobulin variable (IgV) domain of B7-H3 also known as CD276), a member of the B7 family of immune checkpoint molecules. B7-H3 is an important immune checkpoint member of the B7 family and shares homology with other B7 ligands such as programmed death ligand 1 (PD-L1). The B7 family molecules interact with CD28 on T-cells to provide co-stimulatory signals that regulate T-cell activation and T-helper cell differentiation. Although B7-H3 has been shown to have both co-stimulatory and co-inhibitory effects on T-cell responses, the most current studies describe B7-H3 as a T cell inhibitor that promotes tumor aggressiveness and proliferation. Moreover, B7-H3 is highly overexpressed on a wide range of human solid cancers and promotes tumor growth, metastasis, and drug resistance. Thus, B7-H3 expression in tumors often correlates with both negative prognosis and poor clinical outcome in cancer patients. B7-H3 protein contains a predicted signal peptide, V- and C-like Ig domains (IgV and IgC), a transmembrane region, and an intracellular tail.


Pssm-ID: 409528  Cd Length: 115  Bit Score: 87.27  E-value: 6.29e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762781  36 EQIVIGRLDEDIILPSSF--ERG---SEVVIHWKYQDSYK-VHSYYKGSDHLESQDPRYANRTSLFYNEIQNGNASLFFR 109
Cdd:cd20934   4 EDPVVALVGTDATLRCSFspEPGfslAQLSVFWQLTDTKQlVHSFTESQDQGRDQGSAYANRTALFPDLLAQGNASLRLQ 83

                        90
                ....*....|....
gi 74762781 110 RVSLLDEGIYTCYV 123
Cdd:cd20934  84 RVRVADEGSYTCFV 97
IgV_B7-H4 cd20984
Immunoglobulin Variable (IgV) domain of B7-H4; The members here are composed of the ...
 33-126 1.83e-20

Immunoglobulin Variable (IgV) domain of B7-H4; The members here are composed of the immunoglobulin variable (IgV) domain of B7-H4 (also known as B7-S1, B7x, or Vtcn1). B7-H4 is one of the B7 family of immune-regulatory ligands that act as negative regulators of T cell function; it contains one IgV domain and one IgC domain. The B7-family consists of structurally related cell-surface protein ligands, which bind to receptors on lymphocytes that regulate immune responses. The binding of B7-H4 to unidentified receptors results in the inhibition of TCR-mediated T cell proliferation, cell-cycle progression and IL-2 production. As a co-inhibitory molecule, B7-H4 is widely expressed in tumor tissues and its expression is significantly associated with poor prognosis in human cancers such as glioma, pancreatic cancer, oral squamous cell carcinoma, renal cell carcinoma, and lung cancer.


Pssm-ID: 409576  Cd Length: 110  Bit Score: 86.11  E-value: 1.83e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762781  33 PMNEQIVIGRLDEDIILPSSFE---RGSEVVIHW-KYQDSYKVHSYYKGSDHLESQDPRYANRTSLFYNEIQNGNASLFF 108
Cdd:cd20984   1 TVTAKHLAGNIGEDGILSCTFTpdiKLSDIVIQWlKEGDSGLVHEFKEGKDELSRQSPMFRGRTSLFADQVHVGNASLRL 80

                        90
                ....*....|....*...
gi 74762781 109 RRVSLLDEGIYTCYVGTA 126
Cdd:cd20984  81 KNVQLTDAGTYLCIISNS 98
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 231-330 2.11e-15

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 71.72  E-value: 2.11e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762781   231 LHKMQSEHVSLSCQpvNDYFSPNQDFKVTWSRMKSG--TFSVLAYYlSSSQNTIINESRFSWNKeLINQSDFSMNLMDLN 308
Cdd:pfam07686   6 VTVALGGSVTLPCT--YSSSMSEASTSVYWYRQPPGkgPTFLIAYY-SNGSEEGVKKGRFSGRG-DPSNGDGSLTIQNLT 81

                          90       100
                  ....*....|....*....|....*...
gi 74762781   309 LSDSGEYLCNISSDEY------TLLTIH 330
Cdd:pfam07686  82 LSDSGTYTCAVIPSGEgvfgkgTRLTVL 109
IgV_MOG_like cd05713
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here ...
 66-122 2.75e-10

Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here are composed of the immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG). MOG, a minor component of the myelin sheath, is an important CNS-specific autoantigen, linked to the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). It is a transmembrane protein having an extracellular Ig domain. MOG is expressed in the CNS on the outermost lamellae of the myelin sheath, and on the surface of oligodendrocytes, and may participate in the completion, compaction, and/or maintenance of myelin. This group also includes butyrophilin (BTN). BTN is the most abundant protein in bovine milk-fat globule membrane (MFGM).


Pssm-ID: 409378  Cd Length: 114  Bit Score: 57.20  E-value: 2.75e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 74762781  66 QDSYKVHSYYKGSDHLESQDPRYANRTSLFYNEIQNGNASLFFRRVSLLDEGIYTCY 122
Cdd:cd05713  41 QFSPVVHLYRDGQDQEEEQMPEYRGRTELLKDAIAEGSVALRIHNVRPSDEGQYTCF 97
IGv smart00406
Immunoglobulin V-Type;
239-317 3.20e-07

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 47.76  E-value: 3.20e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762781    239 VSLSCQpvndyFSPNQ--DFKVTWSRMKSGTFSVLAYYLSSSQNTIINES---RFSWNKELiNQSDFSMNLMDLNLSDSG 313
Cdd:smart00406   2 VTLSCK-----FSGSTfsSYYVSWVRQPPGKGLEWLGYIGSNGSSYYQESykgRFTISKDT-SKNDVSLTISNLRVEDTG 75


                   ....
gi 74762781    314 EYLC 317
Cdd:smart00406  76 TYYC 79
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 39-138 9.74e-07

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 47.07  E-value: 9.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762781    39 VIGRLDEDIILP---SSFERGSEVVIHWKYQDSYKVHS----YYKGSDHLESQDPRYANRTSlfyneIQNGNASLFFRRV 111
Cdd:pfam07686   6 VTVALGGSVTLPctySSSMSEASTSVYWYRQPPGKGPTfliaYYSNGSEEGVKKGRFSGRGD-----PSNGDGSLTIQNL 80

                          90       100
                  ....*....|....*....|....*...
gi 74762781   112 SLLDEGIYTCYVGTA-IQVITNKVVLKV 138
Cdd:pfam07686  81 TLSDSGTYTCAVIPSgEGVFGKGTRLTV 108
IgV_CD86 cd16087
Immunoglobulin variable domain (IgV) in Cluster of Differentiation (CD) 86; The members here ...
 57-123 2.65e-06

Immunoglobulin variable domain (IgV) in Cluster of Differentiation (CD) 86; The members here are composed of the immunoglobulin variable region (IgV) in the Cluster of Differentiation (CD) 86). Glycoproteins B7-1 (also known as cluster of differentiation (CD) 80) and B7-2 (also known as CD86) are expressed on antigen-presenting cells and deliver the co-stimulatory signal through CD28 and CTLA-4 (also known as CD152) on T cells. signaling through CD28 augments the T-cell response, whereas CTLA-4 signaling attenuates it. The CTLA-4 and B7-2 monomers are both two-layer beta-sandwiches that display the chain topology characteristic of the immunoglobulin variable (V-type) domains present in antigen receptors. The front and back sheets of B7-2 are composed of AGFCC'C" and BED strands, respectively. Members of the IgV family are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond.


Pssm-ID: 409508  Cd Length: 108  Bit Score: 45.78  E-value: 2.65e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 74762781  57 SEVVIHWKYQDSYKVHSYYKGSDHLESQDPRYANRTSLfyneiQNGNASLFFRRVSLLDEGIYTCYV 123
Cdd:cd16087  26 SELVVFWQDQKKLVLYELYLGKEKLDNVNSKYIGRTSF-----DQENWTLQLHNVQIKDQGTYQCFI 87
IgV_PDl1 cd20947
Immunoglobulin Variable (IgV) domain of Programmed death ligand 1 (PD-L1); The members here ...
 59-134 6.25e-06

Immunoglobulin Variable (IgV) domain of Programmed death ligand 1 (PD-L1); The members here are composed of the immunoglobulin variable (IgV) domain of Programmed death ligand 1 (PD-L1; also known as Cluster of Differentiation 274 (CD274)). PD-L1 is a cell-surface ligand that competes with PD-L2 for binding to the immunosuppressive receptor programmed death-1 (PD-1). PD-1 is a member of the B7 family that plays an important role in negatively regulating immune responses upon interaction with its two ligands, PD-L1 or PD-L2. Like PD-L2, PD-L1 interacts with PD-1 and suppresses T cell proliferation and cytokine production. The PD-1 receptor is expressed on the surface of activated T cells, while PD-L1 is expressed on cancer cells. When PD-1 and PD-L1 bind together, they form a molecular shield protecting tumor cells from being destroyed by the immune system. Thus, inhibiting the binding of PD-L1 to PD-1 with an antibody leads to killing of tumor cells by T cells. PD-1 inhibitors (such as Pembrolizumab, Nivolumab, and Cemiplimab) and PD-L1 inhibitors (such as Atezolizumab, Avelumab, and Durvalumab ) are an emerging class of immunotherapy that stimulate lymphocytes against tumor cells.


Pssm-ID: 409539  Cd Length: 110  Bit Score: 44.92  E-value: 6.25e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 74762781  59 VVIHWKYQDSyKVHSYYKGSDHLESQDPRYANRTSLFYNEIQNGNASLFFRRVSLLDEGIYTC---YVGTAIQVITNKV 134
Cdd:cd20947  33 LIVYWEMEDK-NIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCmisYGGADYKRITVKV 110
IgC1 cd00098
Immunoglobulin Constant-1 (C1)-set domain; The members here are composed of C1-set domains, ...
 140-220 1.26e-05

Immunoglobulin Constant-1 (C1)-set domain; The members here are composed of C1-set domains, classical Ig-like domains resembling the antibody constant domain. Members of the IgC1 family are components of immunoglobulin, T-cell receptors, CD1 cell surface glycoproteins, secretory glycoproteins A/C, and major histocompatibility complex (MHC) class I/II molecules. In immunoglobulins, each chain is composed of one variable domain (IgV) and one or more IgC domains. These names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. The IgV domain is responsible for antigen binding, while the IgC domain is involved in oligomerization and molecular interactions. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other strands by G, F, C, and C'.


Pssm-ID: 409354  Cd Length: 95  Bit Score: 43.60  E-value: 1.26e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762781 140 VFLTPVMKYEKRNTNSFLICSVLSVYPRPI-ITWKMDNTPISENNMEETGSL---DSFSINSPLNIT----GSNSSYECT 211
Cdd:cd00098   2 VTLLPPSPEEKGGGKVTLVCLVSGFYPKDItVTWLKNGVPLTSGVSTSSPVEpndGTYSVTSSLTVPpsdwDEGATYTCV 81


                ....*....
gi 74762781 212 IENSLLKQT 220
Cdd:cd00098  82 VTHESLKSP 90
IgV_CAR_like cd20960
Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and ...
 44-137 4.80e-05

Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins; The members here are composed of the Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins. CAR, which is encoded by human CXADR gene, is a cell adhesion molecule of the Immunoglobulin (Ig) superfamily. The CAR acts as a type I membrane receptor for group B1-B6 coxsackie viruses and subgroup C adenoviruses. For instance, adenovirus interacts with the coxsackievirus and adenovirus receptor to enter epithelial airway cells. The CAR is also shown to be involved in physiological processes such as neuronal and heart development, epithelial tight junction integrity, and tumor suppression. The CAR is a component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. The CAR is also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. The CAR is composed of one V-set and one C2-set Ig module, a single transmembrane helix, and an intracellular domain. This group belongs to the V-set of IgSF domains, having A, B, E and D strands in one beta-sheet and A', G, F, C, C' and C" in the other


Pssm-ID: 409552  Cd Length: 114  Bit Score: 42.44  E-value: 4.80e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762781  44 DEDIILPSSFERGSEVV----IHWKYQDSYKVHSY---YKGSDHLESQDPRYANRTSlFYNEIQNGNASLFFRRVSLLDE 116
Cdd:cd20960  15 GENVTLPCHHQLGLEDQgtldIEWLLLPSDKVEKVvitYSGDRVYNHYYPALKGRVA-FTSNDLSGDASLNISNLKLSDT 93

                        90       100
                ....*....|....*....|.
gi 74762781 117 GIYTCYVGTAIQVITNKVVLK 137
Cdd:cd20960  94 GTYQCKVKKAPGYAWSKITLI 114
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 231-325 8.67e-05

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 41.55  E-value: 8.67e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762781 231 LHKMQSEHVSLSCQpvndYFSPNQDFKVTWSRMKSGTFSVLAYYLSSSQNTIIN--ESRFSWNKELinQSDFSMNLMDLN 308
Cdd:cd00099   8 LSVQEGESVTLSCE----VSSSFSSTYIYWYRQKPGQGPEFLIYLSSSKGKTKGgvPGRFSGSRDG--TSSFSLTISNLQ 81

                        90       100
                ....*....|....*....|.
gi 74762781 309 LSDSGEYLC----NISSDEYT 325
Cdd:cd00099  82 PEDSGTYYCavseSGGTDKLT 102
C1-set pfam07654
Immunoglobulin C1-set domain;
140-214 3.08e-04

Immunoglobulin C1-set domain;


Pssm-ID: 462221  Cd Length: 85  Bit Score: 39.16  E-value: 3.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762781   140 VFLTPVMKYEKRNTNSfLICSVLSVYPRPI-ITWKMDNTPISENNMEETGSLD---SFSINSPLNITGSN----SSYECT 211
Cdd:pfam07654   1 VYVFPPSPEELGKPNT-LTCLVTGFYPPDItVTWLKNGQEVTEGVKTTPPSPNsdwTYQLSSYLTVTPSDwesgDEYTCR 79


                  ...
gi 74762781   212 IEN 214
Cdd:pfam07654  80 VEH 82
IgV_1_PVR_like cd05718
First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 ...
 39-125 3.12e-04

First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 and necl-5), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and nectin-like protein 5 (necl-5)). Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), that result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and CD155-gamma are secreted; CD155-alpha and CD155-delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon" with a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the first Ig-like domain of nectin-1 (also known as poliovirus receptor related protein(PVRL)1; CD111), nectin-3 (also known as PVRL 3), nectin-4 (also known as PVRL4; LNIR receptor)and DNAX accessory molecule 1 (DNAM-1; CD226).


Pssm-ID: 409383  Cd Length: 113  Bit Score: 40.12  E-value: 3.12e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762781  39 VIGRLDEDIILPSSFERGSEVVI--------HWKYQDSYKVHSYYKGSDHLESqdprYANRTSLFYNEIQNGNASLFFRR 110
Cdd:cd05718   9 VTGFLGGSVTLPCSLTSPGTTKItqvtwmkiGAGSSQNVAVFHPQYGPSVPNP----YAERVEFLAARLGLRNATLRIRN 84

                        90
                ....*....|....*
gi 74762781 111 VSLLDEGIYTCYVGT 125
Cdd:cd05718  85 LRVEDEGNYICEFAT 99
IgV_TCR_beta cd05899
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here ...
 233-322 3.53e-04

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here are composed of the immunoglobulin (Ig) variable domain of the beta chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the alpha chain of alpha/beta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409480  Cd Length: 110  Bit Score: 39.96  E-value: 3.53e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762781 233 KMQSEHVSLSCQPVNDYFSpnqdfkVTWSRMKSG-TFSVLAYYLSSSQNTIIN--ESRFSWNKEliNQSDFSMNLMDLNL 309
Cdd:cd05899  10 KRRGQSVTLRCSQKSGHDN------MYWYRQDPGkGLQLLFYSYGGGLNEEGDlpGDRFSASRP--SLTRSSLTIKSAEP 81

                        90
                ....*....|...
gi 74762781 310 SDSGEYLCNISSD 322
Cdd:cd05899  82 EDSAVYLCASSLG 94
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 237-334 1.38e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 37.48  E-value: 1.38e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762781    237 EHVSLSCQpvndyFSPNQDFKVTWSRmksgtfsvlayylsSSQNTIINESRFSWNKeliNQSDFSMNLMDLNLSDSGEYL 316
Cdd:smart00410  10 ESVTLSCE-----ASGSPPPEVTWYK--------------QGGKLLAESGRFSVSR---SGSTSTLTISNVTPEDSGTYT 67

                           90
                   ....*....|....*...
gi 74762781    317 CNISSDEYTLLTIHTVHV 334
Cdd:smart00410  68 CAATNSSGSASSGTTLTV 85
IgC1_CD1 cd21029
Immunoglobulin domain of Cluster of Differentiation (CD) 1; member of the C1-set of Ig ...
 157-225 1.86e-03

Immunoglobulin domain of Cluster of Differentiation (CD) 1; member of the C1-set of Ig superfamily (IgSF) domains; The members here are composed of the immunoglobulin domain of Cluster of Differentiation (CD) 1. CD1 family of transmembrane glycoproteins, are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. They mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes (CD1a, CD1b, CD1c, CD1d, and CD1e) organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. CD1a localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternative splicing results in multiple transcript variants. Immunoglobulin (Ig) domain of major histocompatibility complex (MHC) class I alpha chain. Class I MHC proteins bind antigenic peptide fragments and present them to CD8+ T lymphocytes. Class I molecules consist of a transmembrane alpha chain and a small chain called the beta-2-microglobulin. The alpha chain contains three extracellular domains, two of which fold together to form the peptide-binding cleft (alpha1 and alpha2), and one which has an Ig fold (alpha3). Peptide binding to class I molecules occurs in the endoplasmic reticulum (ER) and involves both chaperones and dedicated factors to assist in peptide loading. Class I MHC molecules are expressed on most nucleated cells. C1-set Ig domains have one beta sheet that is formed by strands A, B, E, and D and the other strands by G, F, C, and C'.


Pssm-ID: 409620  Cd Length: 93  Bit Score: 37.30  E-value: 1.86e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 74762781 157 LICSVLSVYPRPI-ITWKMDNTPISeNNMEETGSL----DSFSINSPLNIT-GSNSSYECTIENSLLKQTWTGRW 225
Cdd:cd21029  20 LSCHVTGFYPRPIeVTWLRDGQEQM-DGTQSGGILpnhdGTYQLRKTLDIApGEGAGYSCRVDHSSLKQDLIVYW 93
IgI_7_Dscam cd20954
Seventh immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar ...
 51-138 2.06e-03

Seventh immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the seventh immunoglobulin domain of the Drosophila melanogaster Down syndrome cell adhesion molecule (DSCAM) protein and similar proteins. Down syndrome cell adhesion molecule (DSCAM) is a cell adhesion molecule that plays critical roles in neural development, including axon guidance and branching, axon target recognition, self-avoidance and synaptic formation. DSCAM belongs to the immunoglobulin superfamily and contributes to defects in the central nervous system in Down syndrome patients. Vertebrate DSCAMs differ from Drosophila Dscam1 in that they lack the extensive alternative splicing that occurs in the insect gene. Drosophila melanogaster Dscam has 38,016 isoforms generated by the alternative splicing of four variable exon clusters, which allows every neuron in the fly to display a distinctive set of Dscam proteins on its cell surface. Drosophila Dscam1 is a cell-surface protein that plays important roles in neural development and axon tiling of neurons. It is shown that thousands of isoforms bind themselves through specific homophilic (self-binding) interactions, a process which mediates cellular self-recognition. Drosophila Dscam2 is also alternatively spliced and plays a key role in the development of two visual system neurons, monopolar cells L1 and L2. This group is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand.


Pssm-ID: 409546 [Multi-domain]  Cd Length: 96  Bit Score: 37.29  E-value: 2.06e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762781  51 SSFERGSEVVIHWKYQDSYKVHSYYK---GSDHLESQDPRYANRTSLFyneiqnGNASLFFRRVSLLDEGIYTCYVGTAI 127
Cdd:cd20954  11 ANVAAGQDVMLHCQADGFPTPTVTWKkatGSTPGEYKDLLYDPNVRIL------PNGTLVFGHVQKENEGHYLCEAKNGI 84

                        90
                ....*....|..
gi 74762781 128 QVITNKVV-LKV 138
Cdd:cd20954  85 GSGLSKVIfLKV 96
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 157-214 2.89e-03

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 36.39  E-value: 2.89e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 74762781   157 LICSVLSvYPRPIITWKMDNTPISENNMEETGSLDSFSInspLNITGSNSS----YECTIEN 214
Cdd:pfam13927  21 LTCEATG-SPPPTITWYKNGEPISSGSTRSRSLSGSNST---LTISNVTRSdagtYTCVASN 78
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 157-220 4.30e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 35.77  E-value: 4.30e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 74762781 157 LICSVlSVYPRPIITWKMDNTPISENNMEETGSLDSFSInspLNITGSNSS----YECTIENSLLKQT 220
Cdd:cd00096   3 LTCSA-SGNPPPTITWYKNGKPLPPSSRDSRRSELGNGT---LTISNVTLEdsgtYTCVASNSAGGSA 66
IgV_B7-H2 cd20935
Immunoglobulin Variable (IgV) domain of B7-H2 (B7 homolog 2); The members here are composed of ...
 57-123 7.20e-03

Immunoglobulin Variable (IgV) domain of B7-H2 (B7 homolog 2); The members here are composed of the immunoglobulin variable (IgV) domain of B7-H2 (B7 homolog 2 also known as ICOSL (inducible T cell costimulator ligand) or CD275). B7-H2 is a ligand for the T-cell-specific cell surface receptor ICOS and acts as a costimulatory signal for T-cell proliferation and cytokine secretion. The interaction of ICOS with ICOSL (B7-H2) regulates T cell activation and expansion, is involved in T cell dependent B cell activation, and T-helper cell differentiation. It is a member of the B7 family of immune regulatory proteins and shares homology with other B7 ligands, such as B7-1, B7-2, B7-H1 (PD-L1), PD-L2, and B7-H3. The extracellular domains of B7 proteins contain two Ig-like domains and all members have short cytoplasmic domains. These ligands are typically expressed on antigen presenting cells (such as macrophages, B cells and dendritic cells) and have the ability to regulate T-cell proliferation and function. Tumor cells are also capable of expressing the B7 family members in order to evade immune surveillance.


Pssm-ID: 409529  Cd Length: 113  Bit Score: 35.99  E-value: 7.20e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 74762781  57 SEVVIHWKYQDSYKVHSYY-KGSDHLESQDPRYANRTSLFYNEIQNGNASLFFRRVSLLDEGIYTCYV 123
Cdd:cd20935  26 NDLYVYWQISESETVVTYHlPQNSSLENVDSHYRNRALLSLDSMKQGDFSLRLFNVTPQDEQKFHCLV 93
I-set pfam07679
Immunoglobulin I-set domain;
165-220 7.68e-03

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 35.31  E-value: 7.68e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762781   165 YPRPIITWKMDNTPISEN---NMEETGSLDSFSINsplNITGSNS-SYECTIENSLLKQT 220
Cdd:pfam07679  27 TPDPEVSWFKDGQPLRSSdrfKVTYEGGTYTLTIS---NVQPDDSgKYTCVATNSAGEAE 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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