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Conserved domains on  [gi|74762612|sp|Q8TCA0|]
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RecName: Full=Leucine-rich repeat-containing protein 20

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
26-156 1.30e-19

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.99  E-value: 1.30e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762612  26 TLDLAECKLVSFPIGIYKvLRNvsgqIHLITLANNELKSLTSKFmTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDLS 105
Cdd:COG4886 117 SLDLSGNQLTDLPEELAN-LTN----LKELDLSNNQLTDLPEPL-GNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLS 190

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 74762612 106 RNQFQDFPEQLTALPALETINLEENEIVDVPVEkLAAMPALRSINLRFNPL 156
Cdd:COG4886 191 NNQITDLPEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQL 240
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
26-156 1.30e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.99  E-value: 1.30e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762612  26 TLDLAECKLVSFPIGIYKvLRNvsgqIHLITLANNELKSLTSKFmTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDLS 105
Cdd:COG4886 117 SLDLSGNQLTDLPEELAN-LTN----LKELDLSNNQLTDLPEPL-GNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLS 190

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 74762612 106 RNQFQDFPEQLTALPALETINLEENEIVDVPVEkLAAMPALRSINLRFNPL 156
Cdd:COG4886 191 NNQITDLPEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQL 240
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 74-161 4.00e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.94  E-value: 4.00e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762612  74 SQLRELHLEGNflhRLPSEVS---------ALQH-LKAIDLSRNQFQDfPEQLTALPALETINLEENEIVDVP--VEKLA 141
Cdd:cd21340  90 TNLEELHIENQ---RLPPGEKltfdprslaALSNsLRVLNISGNNIDS-LEPLAPLRNLEQLDASNNQISDLEelLDLLS 165

                        90       100
                ....*....|....*....|
gi 74762612 142 AMPALRSINLRFNPLNAEVR 161
Cdd:cd21340 166 SWPSLRELDLTGNPVCKKPK 185
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
7-184 4.09e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 52.01  E-value: 4.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762612    7 EAVARVARKVNETVESGSDTLDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKFMttfSQLRELHLEGNFL 86
Cdd:PRK15370 156 EAPAKEAANREEAVQRMRDCLKNNKTELRLKILGLTTIPACIPEQITTLILDNNELKSLPENLQ---GNIKTLYANSNQL 232

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762612   87 HRLPSEVSalQHLKAIDLSRNQFQDFPEQLTAlpALETINLEENEI-------------VDVPVEKLAAMPA-----LRS 148
Cdd:PRK15370 233 TSIPATLP--DTIQEMELSINRITELPERLPS--ALQSLDLFHNKIsclpenlpeelryLSVYDNSIRTLPAhlpsgITH 308

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 74762612  149 INLRFNPLNAEVRVIAPPLikfDMLMSPEGARAPLP 184
Cdd:PRK15370 309 LNVQSNSLTALPETLPPGL---KTLEAGENALTSLP 341
LRR_8 pfam13855
Leucine rich repeat;
74-132 2.84e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 2.84e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74762612    74 SQLRELHLEGNFLHRLPSEV-SALQHLKAIDLSRNQFQDF-PEQLTALPALETINLEENEI 132
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
26-156 1.30e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.99  E-value: 1.30e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762612  26 TLDLAECKLVSFPIGIYKvLRNvsgqIHLITLANNELKSLTSKFmTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDLS 105
Cdd:COG4886 117 SLDLSGNQLTDLPEELAN-LTN----LKELDLSNNQLTDLPEPL-GNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLS 190

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 74762612 106 RNQFQDFPEQLTALPALETINLEENEIVDVPVEkLAAMPALRSINLRFNPL 156
Cdd:COG4886 191 NNQITDLPEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQL 240
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
26-156 3.53e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.75  E-value: 3.53e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762612  26 TLDLAECKLVSFPigiyKVLRNVSgQIHLITLANNELKSLtSKFMTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDLS 105
Cdd:COG4886 140 ELDLSNNQLTDLP----EPLGNLT-NLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLS 213

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 74762612 106 RNQFQDFPEQLTALPALETINLEENEIVDVPveKLAAMPALRSINLRFNPL 156
Cdd:COG4886 214 GNQLTDLPEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
23-157 7.53e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.20  E-value: 7.53e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762612  23 GSDTLDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTskfmttfsQLRELHLEGNFLHRLPSEVSALQHLKAI 102
Cdd:COG4886  70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLT--------NLESLDLSGNQLTDLPEELANLTNLKEL 141

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 74762612 103 DLSRNQFQDFPEQLTALPALETINLEENEIVDVPVEkLAAMPALRSINLRFNPLN 157
Cdd:COG4886 142 DLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQIT 195
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
26-173 3.25e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.10  E-value: 3.25e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762612  26 TLDLAECKLVSFPIGIYKvLRNvsgqIHLITLANNELKSLtSKFMTTFSQLRELHLEGNFLHRLPsEVSALQHLKAIDLS 105
Cdd:COG4886 186 ELDLSNNQITDLPEPLGN-LTN----LEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLS 258

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 74762612 106 RNQFQDFPEqLTALPALETINLEENEIVDVPVEKLAAMPALRSINLRFNPLNAEVRVIAPPLIKFDML 173
Cdd:COG4886 259 NNQLTDLPP-LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLL 325
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 74-161 4.00e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.94  E-value: 4.00e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762612  74 SQLRELHLEGNflhRLPSEVS---------ALQH-LKAIDLSRNQFQDfPEQLTALPALETINLEENEIVDVP--VEKLA 141
Cdd:cd21340  90 TNLEELHIENQ---RLPPGEKltfdprslaALSNsLRVLNISGNNIDS-LEPLAPLRNLEQLDASNNQISDLEelLDLLS 165

                        90       100
                ....*....|....*....|
gi 74762612 142 AMPALRSINLRFNPLNAEVR 161
Cdd:cd21340 166 SWPSLRELDLTGNPVCKKPK 185
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
7-184 4.09e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 52.01  E-value: 4.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762612    7 EAVARVARKVNETVESGSDTLDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKFMttfSQLRELHLEGNFL 86
Cdd:PRK15370 156 EAPAKEAANREEAVQRMRDCLKNNKTELRLKILGLTTIPACIPEQITTLILDNNELKSLPENLQ---GNIKTLYANSNQL 232

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762612   87 HRLPSEVSalQHLKAIDLSRNQFQDFPEQLTAlpALETINLEENEI-------------VDVPVEKLAAMPA-----LRS 148
Cdd:PRK15370 233 TSIPATLP--DTIQEMELSINRITELPERLPS--ALQSLDLFHNKIsclpenlpeelryLSVYDNSIRTLPAhlpsgITH 308

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 74762612  149 INLRFNPLNAEVRVIAPPLikfDMLMSPEGARAPLP 184
Cdd:PRK15370 309 LNVQSNSLTALPETLPPGL---KTLEAGENALTSLP 341
PLN03150 PLN03150
hypothetical protein; Provisional
 89-160 9.34e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.89  E-value: 9.34e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 74762612   89 LPSEVSALQHLKAIDLSRNQFQ-DFPEQLTALPALETINLEENEIVDVPVEKLAAMPALRSINLRFNPLNAEV 160
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRV 506
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 52-160 1.05e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.92  E-value: 1.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762612   52 IHLITLANNELKSLTSKFMTTFSQLRELHLEGN-FLHRLPsEVSALQHLKAIDLSRNQFQD-FPEQLTALPALETINLEE 129
Cdd:PLN00113 430 VYFLDISNNNLQGRINSRKWDMPSLQMLSLARNkFFGGLP-DSFGSKRLENLDLSRNQFSGaVPRKLGSLSELMQLKLSE 508

                         90       100       110
                 ....*....|....*....|....*....|.
gi 74762612  130 NEIVDVPVEKLAAMPALRSINLRFNPLNAEV 160
Cdd:PLN00113 509 NKLSGEIPDELSSCKKLVSLDLSHNQLSGQI 539
LRR_8 pfam13855
Leucine rich repeat;
74-132 2.84e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 2.84e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74762612    74 SQLRELHLEGNFLHRLPSEV-SALQHLKAIDLSRNQFQDF-PEQLTALPALETINLEENEI 132
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
97-156 3.11e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 3.11e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74762612    97 QHLKAIDLSRNQFQDF-PEQLTALPALETINLEENEIVDVPVEKLAAMPALRSINLRFNPL 156
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
19-182 1.35e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 44.77  E-value: 1.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762612   19 TVESGSDTLDLAECKLVSFPI---GIYKV---------LRNVSGQIHLITLANNELKSLTskfmTTFSQLRELHLEGNFL 86
Cdd:PRK15387 339 TLPSGLQELSVSDNQLASLPTlpsELYKLwaynnrltsLPALPSGLKELIVSGNRLTSLP----VLPSELKELMVSGNRL 414

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762612   87 HRLPSEVSALQHLKaidLSRNQFQDFPEQLTALPALETINLEENEIVDvpveklAAMPALRSInlrfnplnAEVRVIAPP 166
Cdd:PRK15387 415 TSLPMLPSGLLSLS---VYRNQLTRLPESLIHLSSETTVNLEGNPLSE------RTLQALREI--------TSAPGYSGP 477

                        170
                 ....*....|....*.
gi 74762612  167 LIKFDMlmspEGARAP 182
Cdd:PRK15387 478 IIRFDM----AGASAP 489
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 22-156 2.88e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.42  E-value: 2.88e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762612  22 SGSDTLDLAECKLVSFPIGIYKVLRNVSGQIHLItLANNEL---------KSLTSKFMttfsQLRELHLEGNFLH----- 87
Cdd:cd00116  81 CGLQELDLSDNALGPDGCGVLESLLRSSSLQELK-LNNNGLgdrglrllaKGLKDLPP----ALEKLVLGRNRLEgasce 155

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 74762612  88 RLPSEVSALQHLKAIDLSRNQFQDF-----PEQLTALPALETINLEENEIVDVPVEKLAA----MPALRSINLRFNPL 156
Cdd:cd00116 156 ALAKALRANRDLKELNLANNGIGDAgiralAEGLKANCNLEVLDLNNNGLTDEGASALAEtlasLKSLEVLNLGDNNL 233
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 76-159 2.94e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.42  E-value: 2.94e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762612  76 LRELHLEGNFLH-----RLPSEVSALQHLKAIDLSRNQF-----QDFPEQLTALPALETINLEENEIVDVPVEKLA-AMP 144
Cdd:cd00116 167 LKELNLANNGIGdagirALAEGLKANCNLEVLDLNNNGLtdegaSALAETLASLKSLEVLNLGDNNLTDAGAAALAsALL 246

                        90
                ....*....|....*....
gi 74762612 145 A----LRSINLRFNPLNAE 159
Cdd:cd00116 247 SpnisLLTLSLSCNDITDD 265
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
10-148 7.92e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 39.38  E-value: 7.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762612   10 ARVARKVNETVESGSDTLDLAECKLVSFPigiykvlRNVSGQIHLITLANNELKSLTSkfmtTFSQLRELHLEGNFLHRL 89
Cdd:PRK15387 189 AAVVQKMRACLNNGNAVLNVGESGLTTLP-------DCLPAHITTLVIPDNNLTSLPA----LPPELRTLEVSGNQLTSL 257

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 74762612   90 PS------EVS----ALQHLKAIDLSRNQFQDFPEQLTALPALETiNLEENEIVDvpvEKLAAMPALRS 148
Cdd:PRK15387 258 PVlppgllELSifsnPLTHLPALPSGLCKLWIFGNQLTSLPVLPP-GLQELSVSD---NQLASLPALPS 322
PLN03150 PLN03150
hypothetical protein; Provisional
 57-130 1.49e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 38.64  E-value: 1.49e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 74762612   57 LANNELKSLTSKFMTTFSQLRELHLEGNFLH-RLPSEVSALQHLKAIDLSRNQFQ-DFPEQLTALPALETINLEEN 130
Cdd:PLN03150 425 LDNQGLRGFIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGN 500
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 57-160 2.04e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 38.29  E-value: 2.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762612   57 LANNELKSLTSKFMTTFSQLRELHLEGNFL-HRLPSEVSALQHLKAIDLSRNQFQ-DFPEQLTALPALETINLEENEIV- 133
Cdd:PLN00113 147 LSNNMLSGEIPNDIGSFSSLKVLDLGGNVLvGKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLGYNNLSg 226

                         90       100
                 ....*....|....*....|....*..
gi 74762612  134 DVPVEkLAAMPALRSINLRFNPLNAEV 160
Cdd:PLN00113 227 EIPYE-IGGLTSLNHLDLVYNNLTGPI 252
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 41-160 3.27e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 37.52  E-value: 3.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762612   41 IYKVLRNVSGQI-----------HLITLANNelksLTSKFMTTFSQLRELHL----EGNFLHRLPSEVSALQHLKAIDLS 105
Cdd:PLN00113 217 IYLGYNNLSGEIpyeiggltslnHLDLVYNN----LTGPIPSSLGNLKNLQYlflyQNKLSGPIPPSIFSLQKLISLDLS 292

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 74762612  106 RNQFQ-DFPEQLTALPALETINLEENEIVDVPVEKLAAMPALRSINLRFNPLNAEV 160
Cdd:PLN00113 293 DNSLSgEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEI 348
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 2-159 3.77e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 36.95  E-value: 3.77e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762612   2 LKKMGEA-VARVARKVNETVESgsdtLDLAECKL---VSFPIGiyKVLRnVSGQIHLITLANNELKS----LTSKFMTTF 73
Cdd:cd00116 120 LGDRGLRlLAKGLKDLPPALEK----LVLGRNRLegaSCEALA--KALR-ANRDLKELNLANNGIGDagirALAEGLKAN 192

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762612  74 SQLRELHLEGNFLHR-----LPSEVSALQHLKAIDLSRNQFQDFP--EQLTALPA----LETINLEENEIVDVPVEKLA- 141
Cdd:cd00116 193 CNLEVLDLNNNGLTDegasaLAETLASLKSLEVLNLGDNNLTDAGaaALASALLSpnisLLTLSLSCNDITDDGAKDLAe 272

                       170       180
                ....*....|....*....|.
gi 74762612 142 ---AMPALRSINLRFNPLNAE 159
Cdd:cd00116 273 vlaEKESLLELDLRGNKFGEE 293
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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