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Conserved domains on  [gi|74761374|sp|Q9H069|]
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RecName: Full=Dynein regulatory complex subunit 3; AltName: Full=Leucine-rich repeat-containing protein 48

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 42-188 6.93e-21

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 91.00  E-value: 6.93e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761374  42 FKDVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRI 121
Cdd:cd21340   1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761374 122 SKIDSLDALVK------------------------------LQVLSLGNNRIDNMMNIIYLRRfkcLRTLSLSRNPISEA 171
Cdd:cd21340  81 SVVEGLENLTNleelhienqrlppgekltfdprslaalsnsLRVLNISGNNIDSLEPLAPLRN---LEQLDASNNQISDL 157

                       170
                ....*....|....*..
gi 74761374 172 EDykmfICAYLPDLMYL 188
Cdd:cd21340 158 EE----LLDLLSSWPSL 170
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 42-188 6.93e-21

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 91.00  E-value: 6.93e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761374  42 FKDVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRI 121
Cdd:cd21340   1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761374 122 SKIDSLDALVK------------------------------LQVLSLGNNRIDNMMNIIYLRRfkcLRTLSLSRNPISEA 171
Cdd:cd21340  81 SVVEGLENLTNleelhienqrlppgekltfdprslaalsnsLRVLNISGNNIDSLEPLAPLRN---LEQLDASNNQISDL 157

                       170
                ....*....|....*..
gi 74761374 172 EDykmfICAYLPDLMYL 188
Cdd:cd21340 158 EE----LLDLLSSWPSL 170
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
59-296 3.88e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.20  E-value: 3.88e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761374  59 DNLWQFENLRKLQLDNNIIEKI-EGLENLAHLVWLDLSFNNIETI-EGLDTLVNLEDLSLFNNRISKIDSLDALVKLQVL 136
Cdd:COG4886 176 EELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEEL 255

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761374 137 SLGNNRIDNMMNIIYLRRfkcLRTLSLSRNPISEAEDYKMFICAYLPDLMYLDYRRIDDHTKKLAEAKHQYSIDELKHQE 216
Cdd:COG4886 256 DLSNNQLTDLPPLANLTN---LKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKG 332

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761374 217 NLMQAQLEDEQAQREELEKHKTAFVEHLNGSFLFDSMYAEDSEGNNLSYLPGVGELLETYKDKFVIICVNIFEYGLKQQE 296
Cdd:COG4886 333 LLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVN 412
LRR_9 pfam14580
Leucine-rich repeat;
68-202 7.17e-13

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 66.71  E-value: 7.17e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761374    68 RKLQLDNNIIEKIEGL-ENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKI-DSLD-ALVKLQVLSLGNNRID 144
Cdd:pfam14580  22 RELDLRGYKIPIIENLgATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLGeALPNLTELILTNNNLQ 101

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 74761374   145 NMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICAYLPDLMYLDYRRIDDHTKKLAE 202
Cdd:pfam14580 102 ELGDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAE 159
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 42-188 6.93e-21

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 91.00  E-value: 6.93e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761374  42 FKDVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRI 121
Cdd:cd21340   1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761374 122 SKIDSLDALVK------------------------------LQVLSLGNNRIDNMMNIIYLRRfkcLRTLSLSRNPISEA 171
Cdd:cd21340  81 SVVEGLENLTNleelhienqrlppgekltfdprslaalsnsLRVLNISGNNIDSLEPLAPLRN---LEQLDASNNQISDL 157

                       170
                ....*....|....*..
gi 74761374 172 EDykmfICAYLPDLMYL 188
Cdd:cd21340 158 EE----LLDLLSSWPSL 170
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 54-199 2.44e-19

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 86.76  E-value: 2.44e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761374  54 NILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDL------------------S 115
Cdd:cd21340  35 KITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELhienqrlppgekltfdprS 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761374 116 LF------------NNRISKIDSLDALVKLQVLSLGNNRIDNMMNII-YLRRFKCLRTLSLSRNPISEAEDYKMFICAYL 182
Cdd:cd21340 115 LAalsnslrvlnisGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNPVCKKPKYRDKIILAS 194

                       170
                ....*....|....*..
gi 74761374 183 PDLMYLDYRRIDDHTKK 199
Cdd:cd21340 195 KSLEVLDGKEITDTERQ 211
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
59-296 3.88e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.20  E-value: 3.88e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761374  59 DNLWQFENLRKLQLDNNIIEKI-EGLENLAHLVWLDLSFNNIETI-EGLDTLVNLEDLSLFNNRISKIDSLDALVKLQVL 136
Cdd:COG4886 176 EELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEEL 255

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761374 137 SLGNNRIDNMMNIIYLRRfkcLRTLSLSRNPISEAEDYKMFICAYLPDLMYLDYRRIDDHTKKLAEAKHQYSIDELKHQE 216
Cdd:COG4886 256 DLSNNQLTDLPPLANLTN---LKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKG 332

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761374 217 NLMQAQLEDEQAQREELEKHKTAFVEHLNGSFLFDSMYAEDSEGNNLSYLPGVGELLETYKDKFVIICVNIFEYGLKQQE 296
Cdd:COG4886 333 LLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVN 412
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-170 6.12e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.81  E-value: 6.12e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761374  49 QLDFRNILRIDNLWQFENLRKLQLDNNIIEKI-EGLENLAHLVWLDLSFNNIETI-EGLDTLVNLEDLSLFNNRISKI-D 125
Cdd:COG4886  97 NLTELDLSGNEELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpE 176

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 74761374 126 SLDALVKLQVLSLGNNRIDNMMNIIYlrRFKCLRTLSLSRNPISE 170
Cdd:COG4886 177 ELGNLTNLKELDLSNNQITDLPEPLG--NLTNLEELDLSGNQLTD 219
LRR_9 pfam14580
Leucine-rich repeat;
68-202 7.17e-13

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 66.71  E-value: 7.17e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761374    68 RKLQLDNNIIEKIEGL-ENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKI-DSLD-ALVKLQVLSLGNNRID 144
Cdd:pfam14580  22 RELDLRGYKIPIIENLgATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLGeALPNLTELILTNNNLQ 101

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 74761374   145 NMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICAYLPDLMYLDYRRIDDHTKKLAE 202
Cdd:pfam14580 102 ELGDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAE 159
LRR_8 pfam13855
Leucine rich repeat;
66-121 2.55e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 2.55e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761374    66 NLRKLQLDNNIIEKIEG--LENLAHLVWLDLSFNNIETIEG--LDTLVNLEDLSLFNNRI 121
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
88-143 1.19e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 1.19e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761374    88 HLVWLDLSFNNIETIEG--LDTLVNLEDLSLFNNRISKI--DSLDALVKLQVLSLGNNRI 143
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLspGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
47-152 8.60e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.92  E-value: 8.60e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761374  47 SLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIET--IEGLDTLVNLEDLSLFNNRISKI 124
Cdd:COG4886 232 TLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDlkLKELELLLGLNSLLLLLLLLNLL 311

                        90       100
                ....*....|....*....|....*...
gi 74761374 125 DSLDALVKLQVLSLGNNRIDNMMNIIYL 152
Cdd:COG4886 312 ELLILLLLLTTLLLLLLLLKGLLVTLTT 339
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 110-145 1.23e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.54  E-value: 1.23e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 74761374   110 NLEDLSLFNNRISKIDSLDALVKLQVLSL-GNNRIDN 145
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLsGNNKITD 38
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 88-128 1.69e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.15  E-value: 1.69e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 74761374    88 HLVWLDLSFNNIETIEGLDTLVNLEDLSL-FNNRISKIDSLD 128
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLsGNNKITDLSDLA 43
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 66-106 5.44e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.61  E-value: 5.44e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 74761374    66 NLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNN-IETIEGLD 106
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNkITDLSDLA 43
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-170 8.67e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.84  E-value: 8.67e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761374  40 ILFKDVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNN 119
Cdd:COG4886  27 LLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN 106

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 74761374 120 riskiDSLDALVKLQVLSLGNNRIDNMmnIIYLRRFKCLRTLSLSRNPISE 170
Cdd:COG4886 107 -----EELSNLTNLESLDLSGNQLTDL--PEELANLTNLKELDLSNNQLTD 150
LRR_8 pfam13855
Leucine rich repeat;
110-168 3.83e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 3.83e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 74761374   110 NLEDLSLFNNRISKID--SLDALVKLQVLSLGNNRIdnmmNIIY---LRRFKCLRTLSLSRNPI 168
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDdgAFKGLSNLKVLDLSNNLL----TTLSpgaFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
47-99 3.83e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 3.83e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 74761374    47 SLQLDFRNILRIDNLW--QFENLRKLQLDNNIIEKIEG--LENLAHLVWLDLSFNNI 99
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAfkGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 67-177 5.05e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.26  E-value: 5.05e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761374  67 LRKLQLDNN------IIEKIEGLENLAHLVWLDLSFNNIETI------EGLDTLVNLEDLSLFNNRISKID-------SL 127
Cdd:cd00116 167 LKELNLANNgigdagIRALAEGLKANCNLEVLDLNNNGLTDEgasalaETLASLKSLEVLNLGDNNLTDAGaaalasaLL 246

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 74761374 128 DALVKLQVLSLGNNRI---DNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMF 177
Cdd:cd00116 247 SPNISLLTLSLSCNDItddGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLA 299
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 66-170 6.57e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.00  E-value: 6.57e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761374  66 NLRKLQLDNNIIEK------IEGLENLAHLVWLDLSFNNI------ETIEGLDTLVNLEDLSLFNNRISK------IDSL 127
Cdd:COG5238 265 TVETLYLSGNQIGAegaialAKALQGNTTLTSLDLSVNRIgdegaiALAEGLQGNKTLHTLNLAYNGIGAqgaialAKAL 344

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 74761374 128 DALVKLQVLSLGNNRIDN--MMNII-YLRRFKCLRTLSLSRNPISE 170
Cdd:COG5238 345 QENTTLHSLDLSDNQIGDegAIALAkYLEGNTTLRELNLGKNNIGK 390
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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