Izumo sperm-egg fusion, Ig domain-associated; This IZUMO family is a domain just upstream of the immunoglobulin domain on Izumo proteins in higher eukaryotes. The actual function of this region of the Izumo proteins is not known. The full-length protein is a molecule with a single immunoglobulin (Ig) domain. It is thought that Izumo proteins bind to putative Izumo receptors on the oocyte. Izumo is not detectable on the surface of fresh sperm but becomes exposed only after an exocytotic process, the acrosome reaction, has occurred. Studies have shown that knock-out mice (Izumo-/- males) were sterile despite normal mating behaviour and ejaculation, indicating the importance of the protein in fertilization. There are cysteine residues thought to form a disulphide bridge. Izumo is a typical type I membrane glycoprotein with one immunoglobulin-like domain and a putative N-glycoside link motif (Asn 204). There is a conserved GCL sequence motif. Izumo expression has been found to be testis-specific.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74738278    21 CLQCDPLVLEALGHLRSALIPSRF-QLEQLQARAGAVLMGMEgpfFRDYALNVFVGKVETNQLDLVASFVKNQTQHLMGN 99
Cdd:pfam15005   1 CLQCDPSVVEALKSLRGDLVPSHLpHRKQLMERQQALLLDFS---FKDYALNAFLGVVDEDTLDKVAWSLKNDLKRLTDS 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 74738278   100 SLKDEPLLEELVTLRANVIKEFKKVLISYELKACNPKLCRLLKEEVLDCLHCQRITPKCIHKKYC 164
Cdd:pfam15005  78 DLKGEPLLKELLWMRQNQKKKLKKALKEFQKEACCPNKCGVMLQPVLDCWTCQKITHKCFKGKYC 142

Izumo sperm-egg fusion, Ig domain-associated; This IZUMO family is a domain just upstream of the immunoglobulin domain on Izumo proteins in higher eukaryotes. The actual function of this region of the Izumo proteins is not known. The full-length protein is a molecule with a single immunoglobulin (Ig) domain. It is thought that Izumo proteins bind to putative Izumo receptors on the oocyte. Izumo is not detectable on the surface of fresh sperm but becomes exposed only after an exocytotic process, the acrosome reaction, has occurred. Studies have shown that knock-out mice (Izumo-/- males) were sterile despite normal mating behaviour and ejaculation, indicating the importance of the protein in fertilization. There are cysteine residues thought to form a disulphide bridge. Izumo is a typical type I membrane glycoprotein with one immunoglobulin-like domain and a putative N-glycoside link motif (Asn 204). There is a conserved GCL sequence motif. Izumo expression has been found to be testis-specific.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74738278    21 CLQCDPLVLEALGHLRSALIPSRF-QLEQLQARAGAVLMGMEgpfFRDYALNVFVGKVETNQLDLVASFVKNQTQHLMGN 99
Cdd:pfam15005   1 CLQCDPSVVEALKSLRGDLVPSHLpHRKQLMERQQALLLDFS---FKDYALNAFLGVVDEDTLDKVAWSLKNDLKRLTDS 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 74738278   100 SLKDEPLLEELVTLRANVIKEFKKVLISYELKACNPKLCRLLKEEVLDCLHCQRITPKCIHKKYC 164
Cdd:pfam15005  78 DLKGEPLLKELLWMRQNQKKKLKKALKEFQKEACCPNKCGVMLQPVLDCWTCQKITHKCFKGKYC 142

Izumo sperm-egg fusion, Ig domain-associated; This IZUMO family is a domain just upstream of the immunoglobulin domain on Izumo proteins in higher eukaryotes. The actual function of this region of the Izumo proteins is not known. The full-length protein is a molecule with a single immunoglobulin (Ig) domain. It is thought that Izumo proteins bind to putative Izumo receptors on the oocyte. Izumo is not detectable on the surface of fresh sperm but becomes exposed only after an exocytotic process, the acrosome reaction, has occurred. Studies have shown that knock-out mice (Izumo-/- males) were sterile despite normal mating behaviour and ejaculation, indicating the importance of the protein in fertilization. There are cysteine residues thought to form a disulphide bridge. Izumo is a typical type I membrane glycoprotein with one immunoglobulin-like domain and a putative N-glycoside link motif (Asn 204). There is a conserved GCL sequence motif. Izumo expression has been found to be testis-specific.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74738278    21 CLQCDPLVLEALGHLRSALIPSRF-QLEQLQARAGAVLMGMEgpfFRDYALNVFVGKVETNQLDLVASFVKNQTQHLMGN 99
Cdd:pfam15005   1 CLQCDPSVVEALKSLRGDLVPSHLpHRKQLMERQQALLLDFS---FKDYALNAFLGVVDEDTLDKVAWSLKNDLKRLTDS 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 74738278   100 SLKDEPLLEELVTLRANVIKEFKKVLISYELKACNPKLCRLLKEEVLDCLHCQRITPKCIHKKYC 164
Cdd:pfam15005  78 DLKGEPLLKELLWMRQNQKKKLKKALKEFQKEACCPNKCGVMLQPVLDCWTCQKITHKCFKGKYC 142