NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|74730447|sp|Q8TBB5|]
View 

RecName: Full=Kelch domain-containing protein 4

Protein Classification

Kelch repeat-containing protein( domain architecture ID 11459646)

Kelch repeat-containing protein, member of a superfamily of proteins with diverse functions

CATH:  2.120.10.80
Gene Ontology:  GO:0005515
PubMed:  10603472|31442578|24959344
SCOP:  3000448

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
59-342 1.31e-28

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 114.48  E-value: 1.31e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74730447  59 PPPSPRLNASLSVHPEKdelILFGGEYFNGQktfLYNELYVYNTRKDTWTKVDiPSPPPRRCAHQAVVVpqgGGQLWVFG 138
Cdd:COG3055   8 DLPTPRSEAAAALLDGK---VYVAGGLSGGS---ASNSFEVYDPATNTWSELA-PLPGPPRHHAAAVAQ---DGKLYVFG 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74730447 139 GEFASPNGEQFyhYKDLWVLHLATKTWEQVKSTggPSGRSGHRMVAWKRQLILFGGFHESTrdyiYYNDVYAFNLDTFTW 218
Cdd:COG3055  78 GFTGANPSSTP--LNDVYVYDPATNTWTKLAPM--PTPRGGATALLLDGKIYVVGGWDDGG----NVAWVEVYDPATGTW 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74730447 219 SKLSPSgtgPTPRSGCQMSVTPQGGIVVYGGyskqrvkkdvdkgtRHSDMFLLKpedgredkwvWTRMNPSgvkPTPRSG 298
Cdd:COG3055 150 TQLAPL---PTPRDHLAAAVLPDGKILVIGG--------------RNGSGFSNT----------WTTLAPL---PTARAG 199

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 74730447 299 FSVAmAPNHQTLFFGGvcdeeeeeslSGEFFNDLYFYDATRNRW 342
Cdd:COG3055 200 HAAA-VLGGKILVFGG----------ESGFSDEVEAYDPATNTW 232
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
59-342 1.31e-28

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 114.48  E-value: 1.31e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74730447  59 PPPSPRLNASLSVHPEKdelILFGGEYFNGQktfLYNELYVYNTRKDTWTKVDiPSPPPRRCAHQAVVVpqgGGQLWVFG 138
Cdd:COG3055   8 DLPTPRSEAAAALLDGK---VYVAGGLSGGS---ASNSFEVYDPATNTWSELA-PLPGPPRHHAAAVAQ---DGKLYVFG 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74730447 139 GEFASPNGEQFyhYKDLWVLHLATKTWEQVKSTggPSGRSGHRMVAWKRQLILFGGFHESTrdyiYYNDVYAFNLDTFTW 218
Cdd:COG3055  78 GFTGANPSSTP--LNDVYVYDPATNTWTKLAPM--PTPRGGATALLLDGKIYVVGGWDDGG----NVAWVEVYDPATGTW 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74730447 219 SKLSPSgtgPTPRSGCQMSVTPQGGIVVYGGyskqrvkkdvdkgtRHSDMFLLKpedgredkwvWTRMNPSgvkPTPRSG 298
Cdd:COG3055 150 TQLAPL---PTPRDHLAAAVLPDGKILVIGG--------------RNGSGFSNT----------WTTLAPL---PTARAG 199

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 74730447 299 FSVAmAPNHQTLFFGGvcdeeeeeslSGEFFNDLYFYDATRNRW 342
Cdd:COG3055 200 HAAA-VLGGKILVFGG----------ESGFSDEVEAYDPATNTW 232
PLN02193 PLN02193
nitrile-specifier protein
 77-313 2.30e-18

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 87.70  E-value: 2.30e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74730447   77 ELILFGGEY--FNGQKTFLYNELYVYNTRKDT------WTKVDIPSPPP-RRCAHQavvVPQGGGQLWVFGGEFaSPNGE 147
Cdd:PLN02193 115 KFVLQGGKIvgFHGRSTDVLHSLGAYISLPSTpkllgkWIKVEQKGEGPgLRCSHG---IAQVGNKIYSFGGEF-TPNQP 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74730447  148 QFYHykdLWVLHLATKTWEQVKSTGGPSGRS--GHRMVAWKRQLILFGGFHESTRdyiyYNDVYAFNLDTFTWSKLSPSG 225
Cdd:PLN02193 191 IDKH---LYVFDLETRTWSISPATGDVPHLSclGVRMVSIGSTLYVFGGRDASRQ----YNGFYSFDTTTNEWKLLTPVE 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74730447  226 TGPTPRSGCQMSVTPQgGIVVYGGYS-KQRVK-----KDVDKGTRH----SDMFLLKPEDGRE----DKWV--------- 282
Cdd:PLN02193 264 EGPTPRSFHSMAADEE-NVYVFGGVSaTARLKtldsyNIVDKKWFHcstpGDSFSIRGGAGLEvvqgKVWVvygfngcev 342

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 74730447  283 ------------WTRMNPSGVKPTPRSGFSVAMAPNHQTLFFG 313
Cdd:PLN02193 343 ddvhyydpvqdkWTQVETFGVRPSERSVFASAAVGKHIVIFGG 385
Kelch_4 pfam13418
Galactose oxidase, central domain;
63-117 6.16e-08

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 49.15  E-value: 6.16e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 74730447    63 PRLNASLSVHPeKDELILFGGEYFNGQktfLYNELYVYNTRKDTWTKVdiPSPPP 117
Cdd:pfam13418   1 PRAYHTSTSIP-DDTIYLFGGEGEDGT---LLSDLWVFDLSTNEWTRL--GSLPS 49
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
59-342 1.31e-28

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 114.48  E-value: 1.31e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74730447  59 PPPSPRLNASLSVHPEKdelILFGGEYFNGQktfLYNELYVYNTRKDTWTKVDiPSPPPRRCAHQAVVVpqgGGQLWVFG 138
Cdd:COG3055   8 DLPTPRSEAAAALLDGK---VYVAGGLSGGS---ASNSFEVYDPATNTWSELA-PLPGPPRHHAAAVAQ---DGKLYVFG 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74730447 139 GEFASPNGEQFyhYKDLWVLHLATKTWEQVKSTggPSGRSGHRMVAWKRQLILFGGFHESTrdyiYYNDVYAFNLDTFTW 218
Cdd:COG3055  78 GFTGANPSSTP--LNDVYVYDPATNTWTKLAPM--PTPRGGATALLLDGKIYVVGGWDDGG----NVAWVEVYDPATGTW 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74730447 219 SKLSPSgtgPTPRSGCQMSVTPQGGIVVYGGyskqrvkkdvdkgtRHSDMFLLKpedgredkwvWTRMNPSgvkPTPRSG 298
Cdd:COG3055 150 TQLAPL---PTPRDHLAAAVLPDGKILVIGG--------------RNGSGFSNT----------WTTLAPL---PTARAG 199

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 74730447 299 FSVAmAPNHQTLFFGGvcdeeeeeslSGEFFNDLYFYDATRNRW 342
Cdd:COG3055 200 HAAA-VLGGKILVFGG----------ESGFSDEVEAYDPATNTW 232
PLN02193 PLN02193
nitrile-specifier protein
 77-313 2.30e-18

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 87.70  E-value: 2.30e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74730447   77 ELILFGGEY--FNGQKTFLYNELYVYNTRKDT------WTKVDIPSPPP-RRCAHQavvVPQGGGQLWVFGGEFaSPNGE 147
Cdd:PLN02193 115 KFVLQGGKIvgFHGRSTDVLHSLGAYISLPSTpkllgkWIKVEQKGEGPgLRCSHG---IAQVGNKIYSFGGEF-TPNQP 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74730447  148 QFYHykdLWVLHLATKTWEQVKSTGGPSGRS--GHRMVAWKRQLILFGGFHESTRdyiyYNDVYAFNLDTFTWSKLSPSG 225
Cdd:PLN02193 191 IDKH---LYVFDLETRTWSISPATGDVPHLSclGVRMVSIGSTLYVFGGRDASRQ----YNGFYSFDTTTNEWKLLTPVE 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74730447  226 TGPTPRSGCQMSVTPQgGIVVYGGYS-KQRVK-----KDVDKGTRH----SDMFLLKPEDGRE----DKWV--------- 282
Cdd:PLN02193 264 EGPTPRSFHSMAADEE-NVYVFGGVSaTARLKtldsyNIVDKKWFHcstpGDSFSIRGGAGLEvvqgKVWVvygfngcev 342

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 74730447  283 ------------WTRMNPSGVKPTPRSGFSVAMAPNHQTLFFG 313
Cdd:PLN02193 343 ddvhyydpvqdkWTQVETFGVRPSERSVFASAAVGKHIVIFGG 385
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
43-253 2.97e-18

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 84.82  E-value: 2.97e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74730447  43 FQTLDAKRTQTVELPcPPPSPRLNASLSVHPEkDELILFGGEYFNGQKTFLYNELYVYNTRKDTWTKvdIPSPPPRRCAH 122
Cdd:COG3055  40 FEVYDPATNTWSELA-PLPGPPRHHAAAVAQD-GKLYVFGGFTGANPSSTPLNDVYVYDPATNTWTK--LAPMPTPRGGA 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74730447 123 QAVVVpqgGGQLWVFGGEFASPngeqfyHYKDLWVLHLATKTWEQVKS--------------------TGG--------- 173
Cdd:COG3055 116 TALLL---DGKIYVVGGWDDGG------NVAWVEVYDPATGTWTQLAPlptprdhlaaavlpdgkilvIGGrngsgfsnt 186

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74730447 174 -------PSGRSGHRMVAWKRQLILFGGFHEstrdyiYYNDVYAFNLDTFTWSKLspsGTGPTPRSGcQMSVTPQGGIVV 246
Cdd:COG3055 187 wttlaplPTARAGHAAAVLGGKILVFGGESG------FSDEVEAYDPATNTWTAL---GELPTPRHG-HAAVLTDGKVYV 256


                ....*..
gi 74730447 247 YGGYSKQ 253
Cdd:COG3055 257 IGGETKP 263
PLN02153 PLN02153
epithiospecifier protein
 61-342 3.86e-13

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 70.79  E-value: 3.86e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74730447   61 PSPRLNASLSVhpEKDELILFGGEYFNGQKtfLYNELYVYNTRKDTWTKVDIPSPPPRrCAHQAVVVPQGGGQLWVFGGE 140
Cdd:PLN02153  20 PGPRCSHGIAV--VGDKLYSFGGELKPNEH--IDKDLYVFDFNTHTWSIAPANGDVPR-ISCLGVRMVAVGTKLYIFGGR 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74730447  141 FASPNGEQFYHYKDLwvlhlaTKTWE---QVKSTGGPSGRSGHRMVAWKRQLILFGGFHES--TRDYIYYNDVYAFNLDT 215
Cdd:PLN02153  95 DEKREFSDFYSYDTV------KNEWTfltKLDEEGGPEARTFHSMASDENHVYVFGGVSKGglMKTPERFRTIEAYNIAD 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74730447  216 FTWSKLSPSGTGPTPRSGCQMSVTpQGGIVVYGGYSKQRVKKDVDKGTRHSDMFLlKPEDGRedkwvWTRMNPSGVKPTP 295
Cdd:PLN02153 169 GKWVQLPDPGENFEKRGGAGFAVV-QGKIWVVYGFATSILPGGKSDYESNAVQFF-DPASGK-----WTEVETTGAKPSA 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 74730447  296 RSGFSVAMAPNHQTLFFGGVCDEEEEESLSGEFFNDLYFYDATRNRW 342
Cdd:PLN02153 242 RSVFAHAVVGKYIIIFGGEVWPDLKGHLGPGTLSNEGYALDTETLVW 288
Kelch_4 pfam13418
Galactose oxidase, central domain;
63-117 6.16e-08

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 49.15  E-value: 6.16e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 74730447    63 PRLNASLSVHPeKDELILFGGEYFNGQktfLYNELYVYNTRKDTWTKVdiPSPPP 117
Cdd:pfam13418   1 PRAYHTSTSIP-DDTIYLFGGEGEDGT---LLSDLWVFDLSTNEWTRL--GSLPS 49
Kelch_3 pfam13415
Galactose oxidase, central domain;
75-127 7.31e-08

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 48.83  E-value: 7.31e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 74730447    75 KDELILFGGEYFNGQKtfLYNELYVYNTRKDTWTKVDiPSPPPRRCaHQAVVV 127
Cdd:pfam13415   1 GDKLYIFGGLGFDGQT--RLNDLYVYDLDTNTWTQIG-DLPPPRSG-HSATYI 49
PLN02153 PLN02153
epithiospecifier protein
 70-249 1.76e-06

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 49.98  E-value: 1.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74730447   70 SVHPEKDELILFGGEYFNGQKTF--LYNELYVYNTRKDTWTKVDIPSPPPRRCAHQAVVVPQGggQLWVFGGeFAS---P 144
Cdd:PLN02153 132 SMASDENHVYVFGGVSKGGLMKTpeRFRTIEAYNIADGKWVQLPDPGENFEKRGGAGFAVVQG--KIWVVYG-FATsilP 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74730447  145 NGEQFYHYKDLWVLHLATKTWEQVKSTGG-PSGRSGHRMVAWKRQLILFGGfhESTRDY-------IYYNDVYAFNLDTF 216
Cdd:PLN02153 209 GGKSDYESNAVQFFDPASGKWTEVETTGAkPSARSVFAHAVVGKYIIIFGG--EVWPDLkghlgpgTLSNEGYALDTETL 286

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 74730447  217 TWSKLSPSGTGPTPR---SGCQMSVTPQGGIVVYGG 249
Cdd:PLN02153 287 VWEKLGECGEPAMPRgwtAYTTATVYGKNGLLMHGG 322
Kelch_3 pfam13415
Galactose oxidase, central domain;
186-238 2.03e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 44.59  E-value: 2.03e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 74730447   186 KRQLILFGGFHESTRDYiyYNDVYAFNLDTFTWSKLspsGTGPTPRSGCQMSV 238
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTR--LNDLYVYDLDTNTWTQI---GDLPPPRSGHSATY 48
Kelch_3 pfam13415
Galactose oxidase, central domain;
131-184 4.82e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 43.82  E-value: 4.82e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 74730447   131 GGQLWVFGGEFASPNGeqfyHYKDLWVLHLATKTWEQVKSTggPSGRSGHRMVA 184
Cdd:pfam13415   1 GDKLYIFGGLGFDGQT----RLNDLYVYDLDTNTWTQIGDL--PPPRSGHSATY 48
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 174-216 6.94e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 42.94  E-value: 6.94e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 74730447   174 PSGRSGHRMVAWKRQLILFGGFheSTRDYIYYNDVYAFNLDTF 216
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGY--TGGEGQPSDDVYVLSLPTF 41
Kelch_4 pfam13418
Galactose oxidase, central domain;
176-226 1.36e-05

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 42.21  E-value: 1.36e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 74730447   176 GRSGHRMVAW-KRQLILFGGFhesTRDYIYYNDVYAFNLDTFTWSKLSPSGT 226
Cdd:pfam13418   1 PRAYHTSTSIpDDTIYLFGGE---GEDGTLLSDLWVFDLSTNEWTRLGSLPS 49
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
217-345 2.65e-05

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 45.92  E-value: 2.65e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74730447 217 TWSKLSPSgtgPTPRSGCQMsVTPQGGIVVYGGYSKqrvkkdvdkGTRHSDMFLLKPEDGRedkwvWTRMNPsgvKPTPR 296
Cdd:COG3055   2 TWSSLPDL---PTPRSEAAA-ALLDGKVYVAGGLSG---------GSASNSFEVYDPATNT-----WSELAP---LPGPP 60

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 74730447 297 SGFSVAMAPNHQTLFFGGvcdeEEEESLSGEFFNDLYFYDATRNRWFEG 345
Cdd:COG3055  61 RHHAAAVAQDGKLYVFGG----FTGANPSSTPLNDVYVYDPATNTWTKL 105
PRK14131 PRK14131
N-acetylneuraminate epimerase;
163-313 5.59e-05

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 45.39  E-value: 5.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74730447  163 KTWEQVKS-TGGPsgRSGHRMVAWKRQLILFGGFHESTRD--YIYYNDVYAFNLDTFTWSKL---SPSGTgptprSGcQM 236
Cdd:PRK14131  62 KGWTKIAAfPGGP--REQAVAAFIDGKLYVFGGIGKTNSEgsPQVFDDVYKYDPKTNSWQKLdtrSPVGL-----AG-HV 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74730447  237 SVTPQGG-IVVYGGYSKQ----------RVKKDVDKGTR-HSDMFLLKPEDgredkWVWTR----MNPS-------GVKP 293
Cdd:PRK14131 134 AVSLHNGkAYITGGVNKNifdgyfedlaAAGKDKTPKDKiNDAYFDKKPED-----YFFNKevlsYDPStnqwknaGESP 208

                        170       180
                 ....*....|....*....|.
gi 74730447  294 -TPRSGFSVAMAPNHQTLFFG 313
Cdd:PRK14131 209 fLGTAGSAVVIKGNKLWLING 229
PLN02153 PLN02153
epithiospecifier protein
 165-315 6.17e-05

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 45.36  E-value: 6.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74730447  165 WEQVKSTGG--PSGRSGHRMVAWKRQLILFGGfhESTRDYIYYNDVYAFNLDTFTWSKLSPSGTGPTPRS-GCQMsVTPQ 241
Cdd:PLN02153   9 WIKVEQKGGkgPGPRCSHGIAVVGDKLYSFGG--ELKPNEHIDKDLYVFDFNTHTWSIAPANGDVPRISClGVRM-VAVG 85

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 74730447  242 GGIVVYGGYSKQRVKKDvdkgtrhsdmflLKPEDGREDKWVW-TRMNPSGvKPTPRSGFSVAMAPNHqTLFFGGV 315
Cdd:PLN02153  86 TKLYIFGGRDEKREFSD------------FYSYDTVKNEWTFlTKLDEEG-GPEARTFHSMASDENH-VYVFGGV 146
Kelch_4 pfam13418
Galactose oxidase, central domain;
117-170 1.95e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 39.13  E-value: 1.95e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 74730447   117 PRRCaHQAVVVPqgGGQLWVFGGEfaSPNGEQfyhYKDLWVLHLATKTWEQVKS 170
Cdd:pfam13418   1 PRAY-HTSTSIP--DDTIYLFGGE--GEDGTL---LSDLWVFDLSTNEWTRLGS 46
Kelch_6 pfam13964
Kelch motif;
119-168 2.75e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 38.86  E-value: 2.75e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 74730447   119 RCAHQAVVVpqgGGQLWVFGGefaspNGEQFYHYKDLWVLHLATKTWEQV 168
Cdd:pfam13964   2 RTFHSVVSV---GGYIYVFGG-----YTNASPALNKLEVYNPLTKSWEEL 43
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 177-223 4.19e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 37.98  E-value: 4.19e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 74730447   177 RSGHRMVAWKRQLILFGGFHESTRDyiyyNDVYAFNLDTFTWSKLSP 223
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSL----NSVEVYDPETNTWSKLPS 44
Kelch_4 pfam13418
Galactose oxidase, central domain;
230-286 1.51e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 36.44  E-value: 1.51e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 74730447   230 PRSGCQMSVTPQGGIVVYGGYSkqrvkkdvDKGTRHSDMFLLKPEDGRedkwvWTRM 286
Cdd:pfam13418   1 PRAYHTSTSIPDDTIYLFGGEG--------EDGTLLSDLWVFDLSTNE-----WTRL 44
PRK14131 PRK14131
N-acetylneuraminate epimerase;
76-252 1.52e-03

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 40.77  E-value: 1.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74730447   76 DELILFGG--EYFNGQKTFLYNELYVYNTRKDTWTKVDipSPPPRRCAHQAVVVPQgGGQLWVFGGEfaspNGEQFYHYk 153
Cdd:PRK14131  85 GKLYVFGGigKTNSEGSPQVFDDVYKYDPKTNSWQKLD--TRSPVGLAGHVAVSLH-NGKAYITGGV----NKNIFDGY- 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74730447  154 dlwvlhlatktWEQVKSTGGPSGrsghrmvawKRQLILFGGFHESTRDYIYYNDVYAFNLDTFTWSKLspsgtGPTPRSG 233
Cdd:PRK14131 157 -----------FEDLAAAGKDKT---------PKDKINDAYFDKKPEDYFFNKEVLSYDPSTNQWKNA-----GESPFLG 211

                        170       180
                 ....*....|....*....|.
gi 74730447  234 -CQMSVTPQGG-IVVYGGYSK 252
Cdd:PRK14131 212 tAGSAVVIKGNkLWLINGEIK 232
Kelch_6 pfam13964
Kelch motif;
177-231 8.39e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 34.62  E-value: 8.39e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 74730447   177 RSGHRMVAWKRQLILFGGfheSTRDYIYYNDVYAFNLDTFTWSKLSPSgtgPTPR 231
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGG---YTNASPALNKLEVYNPLTKSWEELPPL---PTPR 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH