|
Name |
Accession |
Description |
Interval |
E-value |
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
1-433 |
2.44e-145 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 420.71 E-value: 2.44e-145
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 1 MSFTDLGLPEWLNESLSNMAITKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPMLAEWSKDPCG-IFGLVLTPTR 79
Cdd:COG0513 2 MSFADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRLDPSRPRaPQALILAPTR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 80 ELAIQIAEQFTALGANMNIRVALIYGGVDMVKQSLELQKMPHFVIATPGRLADHIRSSgedTIRgFRRVRYVVMDEADRL 159
Cdd:COG0513 82 ELALQVAEELRKLAKYLGLRVATVYGGVSIGRQIRALKRGVDIVVATPGRLLDLIERG---ALD-LSGVETLVLDEADRM 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 160 LTPGFVPDLKTCMDLLPdpSKRQTLLFTATVTDAVRALKDRTGEKgpPFIHEIASDIAVPSTLTQSYLFLPGYVREAYLW 239
Cdd:COG0513 158 LDMGFIEDIERILKLLP--KERQTLLFSATMPPEIRKLAKRYLKN--PVRIEVAPENATAETIEQRYYLVDKRDKLELLR 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 240 AILTHPDNEKksAIIFVNRTQTAETLRRMLMALDVKTASLHSEMRQQERVNALGRFRAQAARVLVATDVASRGLDIPTVE 319
Cdd:COG0513 234 RLLRDEDPER--AIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDVS 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 320 MVINFDLPADADDYIHRVGRTARAGRKGQSVSLVTERDVTRVTNIEERVGTKMEKYDlIEDDKVVEEYLTPASTAKRQAV 399
Cdd:COG0513 312 HVINYDLPEDPEDYVHRIGRTGRAGAEGTAISLVTPDERRLLRAIEKLIGQKIEEEE-LPGFEPVEEKRLERLKPKIKEK 390
|
410 420 430
....*....|....*....|....*....|....
gi 74659870 400 LDMEAENFGERKRIQRKKagldvdmKSKNKKPKR 433
Cdd:COG0513 391 LKGKKAGRGGRPGPKGER-------KARRGKRRR 417
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
3-211 |
1.46e-112 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 329.19 E-value: 1.46e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 3 FTDLGLPEWLNESLSNMAITKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPMLAEWSKDPCGIFGLVLTPTRELA 82
Cdd:cd17955 1 FEDLGLSSWLVKQCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPILQRLSEDPYGIFALVLTPTRELA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 83 IQIAEQFTALGANMNIRVALIYGGVDMVKQSLELQKMPHFVIATPGRLADHIRSSGeDTIRGFRRVRYVVMDEADRLLTP 162
Cdd:cd17955 81 YQIAEQFRALGAPLGLRCCVIVGGMDMVKQALELSKRPHIVVATPGRLADHLRSSD-DTTKVLSRVKFLVLDEADRLLTG 159
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 74659870 163 GFVPDLKTCMDLLpdPSKRQTLLFTATVTDAVRALKDRTGEKgpPFIHE 211
Cdd:cd17955 160 SFEDDLATILSAL--PPKRQTLLFSATLTDALKALKELFGNK--PFFWE 204
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
1-442 |
6.64e-82 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 258.72 E-value: 6.64e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 1 MSFTDLGLPEWLNESLSNMAITKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPMLAEWSKDPCGIFG----LVLT 76
Cdd:PRK11192 1 TTFSELELDESLLEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQHLLDFPRRKSGppriLILT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 77 PTRELAIQIAEQFTALGANMNIRVALIYGGVDMVKQSLELQKMPHFVIATPGRLADHIRSSGEDTirgfRRVRYVVMDEA 156
Cdd:PRK11192 81 PTRELAMQVADQARELAKHTHLDIATITGGVAYMNHAEVFSENQDIVVATPGRLLQYIKEENFDC----RAVETLILDEA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 157 DRLLTPGFVPDLKTcmdlLPDPSK--RQTLLFTAT-----VTD-AVRALKDrtgekgPPFIHeiasdiAVPST-----LT 223
Cdd:PRK11192 157 DRMLDMGFAQDIET----IAAETRwrKQTLLFSATlegdaVQDfAERLLND------PVEVE------AEPSRrerkkIH 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 224 QSYLFLPGYVRE-AYLWAILTHPDNEKksAIIFVNRTQTAETLRRMLMALDVKTASLHSEMRQQERVNALGRFRAQAARV 302
Cdd:PRK11192 221 QWYYRADDLEHKtALLCHLLKQPEVTR--SIVFVRTRERVHELAGWLRKAGINCCYLEGEMVQAKRNEAIKRLTDGRVNV 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 303 LVATDVASRGLDIPTVEMVINFDLPADADDYIHRVGRTARAGRKGQSVSLVTERDVtrvtnieeRVGTKMEKYdlIEDD- 381
Cdd:PRK11192 299 LVATDVAARGIDIDDVSHVINFDMPRSADTYLHRIGRTGRAGRKGTAISLVEAHDH--------LLLGKIERY--IEEPl 368
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 74659870 382 --KVVEEyLTPAStakrqavldmEAENFGERKRIQRKKAGLDVDMKSKNKKPKRVAKGKSDKK 442
Cdd:PRK11192 369 kaRVIDE-LRPKT----------KAPSEKKTGKPSKKVLAKRAEKKEKEKEKPKVKKRHRDTK 420
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
1-377 |
6.23e-80 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 254.73 E-value: 6.23e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 1 MSFTDLGLPEWLNESLSNMAITKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPMLAEWSKDPCGIFGLVLTPTRE 80
Cdd:PRK11776 4 TAFSTLPLPPALLANLNELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLLQKLDVKRFRVQALVLCPTRE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 81 LAIQIAEQFTALGANM-NIRVALIYGGVDMVKQSLELQKMPHFVIATPGRLADHIRssgedtiRG---FRRVRYVVMDEA 156
Cdd:PRK11776 84 LADQVAKEIRRLARFIpNIKVLTLCGGVPMGPQIDSLEHGAHIIVGTPGRILDHLR-------KGtldLDALNTLVLDEA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 157 DRLLTPGFVPDLKTCMDLLpdPSKRQTLLFTATVTDAVRALKDRTgEKGPPFIHEIASDIAvpSTLTQSYLFLPGYVREA 236
Cdd:PRK11776 157 DRMLDMGFQDAIDAIIRQA--PARRQTLLFSATYPEGIAAISQRF-QRDPVEVKVESTHDL--PAIEQRFYEVSPDERLP 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 237 YLWAILTH--PDnekkSAIIFVNRTQTAETLRRMLMALDVKTASLHSEMRQQERVNALGRFRAQAARVLVATDVASRGLD 314
Cdd:PRK11776 232 ALQRLLLHhqPE----SCVVFCNTKKECQEVADALNAQGFSALALHGDLEQRDRDQVLVRFANRSCSVLVATDVAARGLD 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 74659870 315 IPTVEMVINFDLPADADDYIHRVGRTARAGRKGQSVSLVTERDVTRVTNIEERVGTKMEKYDL 377
Cdd:PRK11776 308 IKALEAVINYELARDPEVHVHRIGRTGRAGSKGLALSLVAPEEMQRANAIEDYLGRKLNWEPL 370
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
12-197 |
2.74e-73 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 228.48 E-value: 2.74e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 12 LNESLSNMAITKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPMLAEWSKDPC----GIFGLVLTPTRELAIQIAE 87
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLPEPKkkgrGPQALVLAPTRELAMQIAE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 88 QFTALGANMNIRVALIYGGVDMVKQSLELQKMPHFVIATPGRLADHIRssgEDTIRgFRRVRYVVMDEADRLLTPGFVPD 167
Cdd:cd00268 81 VARKLGKGTGLKVAAIYGGAPIKKQIEALKKGPDIVVGTPGRLLDLIE---RGKLD-LSNVKYLVLDEADRMLDMGFEED 156
|
170 180 190
....*....|....*....|....*....|
gi 74659870 168 LKTCMDLLpdPSKRQTLLFTATVTDAVRAL 197
Cdd:cd00268 157 VEKILSAL--PKDRQTLLFSATLPEEVKEL 184
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
2-354 |
2.77e-72 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 236.98 E-value: 2.77e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 2 SFTDLGLPEWLNESLSNMAITKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPMLAEWSKDPCGIFG-----LVLT 76
Cdd:PTZ00110 131 SFEYTSFPDYILKSLKNAGFTEPTPIQVQGWPIALSGRDMIGIAETGSGKTLAFLLPAIVHINAQPLLRYGdgpivLVLA 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 77 PTRELAIQIAEQFTALGANMNIRVALIYGGVDMVKQSLELQKMPHFVIATPGRLADHIrssgEDTIRGFRRVRYVVMDEA 156
Cdd:PTZ00110 211 PTRELAEQIREQCNKFGASSKIRNTVAYGGVPKRGQIYALRRGVEILIACPGRLIDFL----ESNVTNLRRVTYLVLDEA 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 157 DRLLTPGFVPDLKTCMDLL-PDpskRQTLLFTATVTDAVRALKDRTGEKGPPFIHEIASDIAVPSTLTQSYLFLPGYVRE 235
Cdd:PTZ00110 287 DRMLDMGFEPQIRKIVSQIrPD---RQTLMWSATWPKEVQSLARDLCKEEPVHVNVGSLDLTACHNIKQEVFVVEEHEKR 363
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 236 AYLWAILTHPDNEKKSAIIFVNRTQTAETLRRMLMALDVKTASLHSEMRQQERVNALGRFRAQAARVLVATDVASRGLDI 315
Cdd:PTZ00110 364 GKLKMLLQRIMRDGDKILIFVETKKGADFLTKELRLDGWPALCIHGDKKQEERTWVLNEFKTGKSPIMIATDVASRGLDV 443
|
330 340 350
....*....|....*....|....*....|....*....
gi 74659870 316 PTVEMVINFDLPADADDYIHRVGRTARAGRKGQSVSLVT 354
Cdd:PTZ00110 444 KDVKYVINFDFPNQIEDYVHRIGRTGRAGAKGASYTFLT 482
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
1-365 |
1.49e-71 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 237.44 E-value: 1.49e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 1 MSFTDLGLPEWLNESLSNMAITKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPMLAEWSKDPCGIFGLVLTPTRE 80
Cdd:PRK11634 6 TTFADLGLKAPILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLHNLDPELKAPQILVLAPTRE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 81 LAIQIAEQFTALGANMN-IRVALIYGGVDMVKQSLELQKMPHFVIATPGRLADHIRSSGEDtirgFRRVRYVVMDEADRL 159
Cdd:PRK11634 86 LAVQVAEAMTDFSKHMRgVNVVALYGGQRYDVQLRALRQGPQIVVGTPGRLLDHLKRGTLD----LSKLSGLVLDEADEM 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 160 LTPGFVPDLKTCMDLLPDpsKRQTLLFTATVTDAVRALKDRtgekgppFIHE-----IASDIAVPSTLTQSYLFLPGYVR 234
Cdd:PRK11634 162 LRMGFIEDVETIMAQIPE--GHQTALFSATMPEAIRRITRR-------FMKEpqevrIQSSVTTRPDISQSYWTVWGMRK 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 235 EAYLWAILTHPDNEkkSAIIFV---NRT-QTAETLRRMlmalDVKTASLHSEMRQQERVNALGRFRAQAARVLVATDVAS 310
Cdd:PRK11634 233 NEALVRFLEAEDFD--AAIIFVrtkNATlEVAEALERN----GYNSAALNGDMNQALREQTLERLKDGRLDILIATDVAA 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 74659870 311 RGLDIPTVEMVINFDLPADADDYIHRVGRTARAGRKGQSVSLVTERDVTRVTNIE 365
Cdd:PRK11634 307 RGLDVERISLVVNYDIPMDSESYVHRIGRTGRAGRAGRALLFVENRERRLLRNIE 361
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
2-197 |
9.29e-71 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 222.19 E-value: 9.29e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 2 SFTDLGLPEWLNESLSNMAITKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPMLAEWSKDPCGIFGLVLTPTREL 81
Cdd:cd17954 1 TFKELGVCEELCEACEKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILQALLENPQRFFALVLAPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 82 AIQIAEQFTALGANMNIRVALIYGGVDMVKQSLELQKMPHFVIATPGRLADHIrssgEDTiRGF--RRVRYVVMDEADRL 159
Cdd:cd17954 81 AQQISEQFEALGSSIGLKSAVLVGGMDMMAQAIALAKKPHVIVATPGRLVDHL----ENT-KGFslKSLKFLVMDEADRL 155
|
170 180 190
....*....|....*....|....*....|....*...
gi 74659870 160 LTPGFVPDLKTCMDLLpdPSKRQTLLFTATVTDAVRAL 197
Cdd:cd17954 156 LNMDFEPEIDKILKVI--PRERTTYLFSATMTTKVAKL 191
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
1-406 |
5.51e-68 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 226.37 E-value: 5.51e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 1 MSFTDLGLPEWLNESLSNMAITKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAF---------AAPMLAEwsKDPCGIF 71
Cdd:PRK04537 9 LTFSSFDLHPALLAGLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFlvavmnrllSRPALAD--RKPEDPR 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 72 GLVLTPTRELAIQIAEQFTALGANMNIRVALIYGGVDMVKQSLELQKMPHFVIATPGRLADHIRssgEDTIRGFRRVRYV 151
Cdd:PRK04537 87 ALILAPTRELAIQIHKDAVKFGADLGLRFALVYGGVDYDKQRELLQQGVDVIIATPGRLIDYVK---QHKVVSLHACEIC 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 152 VMDEADRLLTPGFVPDLKTCMDLLPDPSKRQTLLFTATvtdavraLKDRTGEKGPPFIHEIASDIAVPSTLT-----QSY 226
Cdd:PRK04537 164 VLDEADRMFDLGFIKDIRFLLRRMPERGTRQTLLFSAT-------LSHRVLELAYEHMNEPEKLVVETETITaarvrQRI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 227 LFLPGYVREAYLWAILTHpdNEKKSAIIFVNRTQTAETLRRMLMALDVKTASLHSEMRQQERVNALGRFRAQAARVLVAT 306
Cdd:PRK04537 237 YFPADEEKQTLLLGLLSR--SEGARTMVFVNTKAFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVAT 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 307 DVASRGLDIPTVEMVINFDLPADADDYIHRVGRTARAGRKGQSVSLVTERDVTRVTNIEERVGTKmekydlIEDDKVVEE 386
Cdd:PRK04537 315 DVAARGLHIDGVKYVYNYDLPFDAEDYVHRIGRTARLGEEGDAISFACERYAMSLPDIEAYIEQK------IPVEPVTAE 388
|
410 420
....*....|....*....|
gi 74659870 387 YLTPASTAKRQAVLDMEAEN 406
Cdd:PRK04537 389 LLTPLPRPPRVPVEGEEADD 408
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
3-373 |
4.76e-63 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 210.92 E-value: 4.76e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 3 FTDLGLPEWLNESLSNMAITKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPMLAEWSKDPCG-------IFGLVL 75
Cdd:PRK01297 89 FHDFNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLISIINQLLQTPPPkerymgePRALII 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 76 TPTRELAIQIAEQFTALGANMNIRVALIYGGVDMVKQSLELQ-KMPHFVIATPGRLADHIRssgedtiRG---FRRVRYV 151
Cdd:PRK01297 169 APTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEaRFCDILVATPGRLLDFNQ-------RGevhLDMVEVM 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 152 VMDEADRLLTPGFVPDLKTCMDLLPDPSKRQTLLFTATVTDAVRAL-KDRTGEkgpPFIHEIASDIAVPSTLTQSYLFLP 230
Cdd:PRK01297 242 VLDEADRMLDMGFIPQVRQIIRQTPRKEERQTLLFSATFTDDVMNLaKQWTTD---PAIVEIEPENVASDTVEQHVYAVA 318
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 231 GYVREAYLWAILThpDNEKKSAIIFVNRTQTAETLRRMLMALDVKTASLHSEMRQQERVNALGRFRAQAARVLVATDVAS 310
Cdd:PRK01297 319 GSDKYKLLYNLVT--QNPWERVMVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGFREGKIRVLVATDVAG 396
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 74659870 311 RGLDIPTVEMVINFDLPADADDYIHRVGRTARAGRKGQSVSLVTERDVTRVTNIEERVGTKME 373
Cdd:PRK01297 397 RGIHIDGISHVINFTLPEDPDDYVHRIGRTGRAGASGVSISFAGEDDAFQLPEIEELLGRKIS 459
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
3-380 |
4.04e-62 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 207.13 E-value: 4.04e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 3 FTDLGLPEWLNESLSNMAITKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPML-------AEWSKDPCGIFGLVL 75
Cdd:PRK04837 10 FSDFALHPQVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTATFhyllshpAPEDRKVNQPRALIM 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 76 TPTRELAIQIAEQFTALGANMNIRVALIYGGVDMVKQSLELQKMPHFVIATPGRLADHIRSSgedtIRGFRRVRYVVMDE 155
Cdd:PRK04837 90 APTRELAVQIHADAEPLAQATGLKLGLAYGGDGYDKQLKVLESGVDILIGTTGRLIDYAKQN----HINLGAIQVVVLDE 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 156 ADRLLTPGFVPDLKTCMDLLPDPSKRQTLLFTATVTDAVRAL---------------KDRTGekgppfiHEIASDIAVPS 220
Cdd:PRK04837 166 ADRMFDLGFIKDIRWLFRRMPPANQRLNMLFSATLSYRVRELafehmnnpeyvevepEQKTG-------HRIKEELFYPS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 221 TLTQSYLFLPGYVREaylWailthPDNekksAIIFVNRTQTAETLRRMLMALDVKTASLHSEMRQQERVNALGRFRAQAA 300
Cdd:PRK04837 239 NEEKMRLLQTLIEEE---W-----PDR----AIIFANTKHRCEEIWGHLAADGHRVGLLTGDVAQKKRLRILEEFTRGDL 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 301 RVLVATDVASRGLDIPTVEMVINFDLPADADDYIHRVGRTARAGRKGQSVSLVTERDVTRVTNIEERVG--TKMEKYD-- 376
Cdd:PRK04837 307 DILVATDVAARGLHIPAVTHVFNYDLPDDCEDYVHRIGRTGRAGASGHSISLACEEYALNLPAIETYIGhsIPVSKYDsd 386
|
....*
gi 74659870 377 -LIED 380
Cdd:PRK04837 387 aLLTD 391
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
1-361 |
1.59e-60 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 203.89 E-value: 1.59e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 1 MSFTDLGLPEWLNESLSNMAITKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPMLAEWSKDPCGIFG------LV 74
Cdd:PRK10590 1 MSFDSLGLSPDILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLITRQPHAKGrrpvraLI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 75 LTPTRELAIQIAEQFTALGANMNIRVALIYGGVDMVKQSLELQKMPHFVIATPGRLADHIRSSGEDtirgFRRVRYVVMD 154
Cdd:PRK10590 81 LTPTRELAAQIGENVRDYSKYLNIRSLVVFGGVSINPQMMKLRGGVDVLVATPGRLLDLEHQNAVK----LDQVEILVLD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 155 EADRLLTPGFVPDLKTCMDLLPdpSKRQTLLFTATVTDAVRALKDRTGEKgpPFIHEIASDIAVPSTLTQSYLFLPGYvR 234
Cdd:PRK10590 157 EADRMLDMGFIHDIRRVLAKLP--AKRQNLLFSATFSDDIKALAEKLLHN--PLEIEVARRNTASEQVTQHVHFVDKK-R 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 235 EAYLWAILTHPDNEKKsAIIFVNRTQTAETLRRMLMALDVKTASLHSEMRQQERVNALGRFRAQAARVLVATDVASRGLD 314
Cdd:PRK10590 232 KRELLSQMIGKGNWQQ-VLVFTRTKHGANHLAEQLNKDGIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDIAARGLD 310
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 74659870 315 IPTVEMVINFDLPADADDYIHRVGRTARAGRKGQSVSLVTE------RDVTRV 361
Cdd:PRK10590 311 IEELPHVVNYELPNVPEDYVHRIGRTGRAAATGEALSLVCVdehkllRDIEKL 363
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
25-197 |
2.00e-56 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 183.98 E-value: 2.00e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 25 SAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPMLAEWSKDPCGIFGLVLTPTRELAIQIAEQFTALGANMNIRVALIY 104
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDNGPQALVLAPTRELAEQIYEELKKLGKGLGLKVASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 105 GGVDMVKQSLELQKmPHFVIATPGRLADHIRSSgedtiRGFRRVRYVVMDEADRLLTPGFVPDLKTCMDLLpdPSKRQTL 184
Cdd:pfam00270 81 GGDSRKEQLEKLKG-PDILVGTPGRLLDLLQER-----KLLKNLKLLVLDEAHRLLDMGFGPDLEEILRRL--PKKRQIL 152
|
170
....*....|...
gi 74659870 185 LFTATVTDAVRAL 197
Cdd:pfam00270 153 LLSATLPRNLEDL 165
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
222-353 |
9.53e-55 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 178.08 E-value: 9.53e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 222 LTQSYLFLPGYVREAYLWAILTHpDNEKKSAIIFVNRTQTAETLRRMLMALDVKTASLHSEMRQQERVNALGRFRAQAAR 301
Cdd:cd18787 1 IKQLYVVVEEEEKKLLLLLLLLE-KLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVR 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 74659870 302 VLVATDVASRGLDIPTVEMVINFDLPADADDYIHRVGRTARAGRKGQSVSLV 353
Cdd:cd18787 80 VLVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
2-374 |
7.68e-54 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 184.64 E-value: 7.68e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 2 SFTDLGLPEWLNESLSNMAITKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAF--AAPMLAEWSKDPCGIfgLVLTPTR 79
Cdd:PTZ00424 29 SFDALKLNEDLLRGIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFviAALQLIDYDLNACQA--LILAPTR 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 80 ELAIQIAEQFTALGANMNIRVALIYGGVDMVKQSLELQKMPHFVIATPGRLADHI--RSSGEDTIRGFrrvryvVMDEAD 157
Cdd:PTZ00424 107 ELAQQIQKVVLALGDYLKVRCHACVGGTVVRDDINKLKAGVHMVVGTPGRVYDMIdkRHLRVDDLKLF------ILDEAD 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 158 RLLTPGFVPDLKTCMDLLPdpSKRQTLLFTATVTDAVRALKDRtgekgppFIHEiasdiavPSTL--TQSYLFLPGyVRE 235
Cdd:PTZ00424 181 EMLSRGFKGQIYDVFKKLP--PDVQVALFSATMPNEILELTTK-------FMRD-------PKRIlvKKDELTLEG-IRQ 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 236 AYL------WAILTHPDNEKK----SAIIFVNRTQTAETLRRMLMALDVKTASLHSEMRQQERVNALGRFRAQAARVLVA 305
Cdd:PTZ00424 244 FYVavekeeWKFDTLCDLYETltitQAIIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLIT 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 74659870 306 TDVASRGLDIPTVEMVINFDLPADADDYIHRVGRTARAGRKGQSVSLVTERDVTRVTNIEERVGTKMEK 374
Cdd:PTZ00424 324 TDLLARGIDVQQVSLVINYDLPASPENYIHRIGRSGRFGRKGVAINFVTPDDIEQLKEIERHYNTQIEE 392
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
2-189 |
8.72e-52 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 173.83 E-value: 8.72e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 2 SFTDLGLPEWLNESLSNMAITKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPMLAEWSKDPCGI----------F 71
Cdd:cd17967 1 SFEEAGLRELLLENIKRAGYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIISKLLEDGPPSvgrgrrkaypS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 72 GLVLTPTRELAIQIAEQFTALGANMNIRVALIYGGVDMVKQSLELQKMPHFVIATPGRLADHIrssgEDTIRGFRRVRYV 151
Cdd:cd17967 81 ALILAPTRELAIQIYEEARKFSYRSGVRSVVVYGGADVVHQQLQLLRGCDILVATPGRLVDFI----ERGRISLSSIKFL 156
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 74659870 152 VMDEADRLLTPGFVPDLKTCMDL--LPDPSKRQTLLFTAT 189
Cdd:cd17967 157 VLDEADRMLDMGFEPQIRKIVEHpdMPPKGERQTLMFSAT 196
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
16-197 |
2.79e-50 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 168.97 E-value: 2.79e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 16 LSNMAITKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPMLAEWSKDPCGIFG---LVLTPTRELAIQIAEQFTAL 92
Cdd:cd17947 5 LSSLGFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPILERLLYRPKKKAAtrvLVLVPTRELAMQCFSVLQQL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 93 GANMNIRVALIYGGVDMVKQSLELQKMPHFVIATPGRLADHIRSSGEDTIRGfrrVRYVVMDEADRLLTPGFVPDLKTCM 172
Cdd:cd17947 85 AQFTDITFALAVGGLSLKAQEAALRARPDIVIATPGRLIDHLRNSPSFDLDS---IEILVLDEADRMLEEGFADELKEIL 161
|
170 180
....*....|....*....|....*
gi 74659870 173 DLLpdPSKRQTLLFTATVTDAVRAL 197
Cdd:cd17947 162 RLC--PRTRQTMLFSATMTDEVKDL 184
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
14-191 |
7.59e-50 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 169.34 E-value: 7.59e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 14 ESLSNMAITKPSAIQKACIPQIMK-GKDCIGGARTGSGKTIAFAAPMLA----------EWSKDPcGIFGLVLTPTRELA 82
Cdd:cd17946 3 RALADLGFSEPTPIQALALPAAIRdGKDVIGAAETGSGKTLAFGIPILErllsqkssngVGGKQK-PLRALILTPTRELA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 83 IQIAEQFTALGANMNIRVALIYGGVDMVKQSLELQKMPHFVIATPGRLADHIrSSGEDTIRGFRRVRYVVMDEADRLLTP 162
Cdd:cd17946 82 VQVKDHLKAIAKYTNIKIASIVGGLAVQKQERLLKKRPEIVVATPGRLWELI-QEGNEHLANLKSLRFLVLDEADRMLEK 160
|
170 180 190
....*....|....*....|....*....|....
gi 74659870 163 GFVPDLKTCMDLLPDPS-----KRQTLLFTATVT 191
Cdd:cd17946 161 GHFAELEKILELLNKDRagkkrKRQTFVFSATLT 194
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
1-357 |
1.77e-48 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 173.05 E-value: 1.77e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 1 MSFTDLGLPEWLNESLSNMAITKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPMLA-------EWSKDPCGIFGL 73
Cdd:PLN00206 121 LSFSSCGLPPKLLLNLETAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTASFLVPIISrcctirsGHPSEQRNPLAM 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 74 VLTPTRELAIQIAEQFTALGANMNIRVALIYGGVDMVKQSLELQKMPHFVIATPGRLADhIRSSGEDTIRGfrrVRYVVM 153
Cdd:PLN00206 201 VLTPTRELCVQVEDQAKVLGKGLPFKTALVVGGDAMPQQLYRIQQGVELIVGTPGRLID-LLSKHDIELDN---VSVLVL 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 154 DEADRLLTPGFVPDLKTCMDLLPDPskrQTLLFTATVTDAVralkdrtgEKgppFIHEIASDIAVPS---------TLTQ 224
Cdd:PLN00206 277 DEVDCMLERGFRDQVMQIFQALSQP---QVLLFSATVSPEV--------EK---FASSLAKDIILISignpnrpnkAVKQ 342
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 225 SYLFLPGYVREAYLWAILTHPDNEKKSAIIFVNRTQTAETLRRML-MALDVKTASLHSEMRQQERVNALGRFRAQAARVL 303
Cdd:PLN00206 343 LAIWVETKQKKQKLFDILKSKQHFKPPAVVFVSSRLGADLLANAItVVTGLKALSIHGEKSMKERREVMKSFLVGEVPVI 422
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 74659870 304 VATDVASRGLDIPTVEMVINFDLPADADDYIHRVGRTARAGRKGQSVSLVTERD 357
Cdd:PLN00206 423 VATGVLGRGVDLLRVRQVIIFDMPNTIKEYIHQIGRASRMGEKGTAIVFVNEED 476
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
2-200 |
3.20e-47 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 161.78 E-value: 3.20e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 2 SFTDLGLPEWLNESLSNMAITKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPMLAE-----WSKDPCGIFGLVLT 76
Cdd:cd17953 13 KWSQCGLSEKVLDLIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFRHikdqrPVKPGEGPIGLIMA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 77 PTRELAIQIAEQFTALGANMNIRVALIYGGVDMVKQSLELQKMPHFVIATPGRLADhIRSSGEDTIRGFRRVRYVVMDEA 156
Cdd:cd17953 93 PTRELALQIYVECKKFSKALGLRVVCVYGGSGISEQIAELKRGAEIVVCTPGRMID-ILTANNGRVTNLRRVTYVVLDEA 171
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 74659870 157 DRLLTPGFVPDL-KTCMDLLPDpskRQTLLFTATVTDAVRALKDR 200
Cdd:cd17953 172 DRMFDMGFEPQImKIVNNIRPD---RQTVLFSATFPRKVEALARK 213
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
2-189 |
3.01e-46 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 158.62 E-value: 3.01e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 2 SFTDLGLPEWLNESLSNMAITKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPMLaEWSKDPCGIFG---LVLTPT 78
Cdd:cd17959 2 GFQSMGLSPPLLRAIKKKGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMI-EKLKAHSPTVGaraLILSPT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 79 RELAIQIAEQFTALGANMNIRVALIYGGVDMVKQSLELQKMPHFVIATPGRLADHIRssgEDTIRgFRRVRYVVMDEADR 158
Cdd:cd17959 81 RELALQTLKVTKELGKFTDLRTALLVGGDSLEEQFEALASNPDIIIATPGRLLHLLV---EMNLK-LSSVEYVVFDEADR 156
|
170 180 190
....*....|....*....|....*....|.
gi 74659870 159 LLTPGFVPDLKTCMDLLPDpsKRQTLLFTAT 189
Cdd:cd17959 157 LFEMGFAEQLHEILSRLPE--NRQTLLFSAT 185
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
14-197 |
3.02e-45 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 156.71 E-value: 3.02e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 14 ESLSNMAITKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPMLAEWSKDPC--------GIFGLVLTPTRELAIQI 85
Cdd:cd17945 3 RVIRKLGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYISRLPPldeetkddGPYALILAPTRELAQQI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 86 AEQFTALGANMNIRVALIYGGVDMVKQSLELQKMPHFVIATPGRLADHIrssgEDTIRGFRRVRYVVMDEADRLLTPGFV 165
Cdd:cd17945 83 EEETQKFAKPLGIRVVSIVGGHSIEEQAFSLRNGCEILIATPGRLLDCL----ERRLLVLNQCTYVVLDEADRMIDMGFE 158
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 74659870 166 PDLKTCMDLLPDPSK------------------RQTLLFTATVTDAVRAL 197
Cdd:cd17945 159 PQVTKILDAMPVSNKkpdteeaeklaasgkhryRQTMMFTATMPPAVEKI 208
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
14-209 |
2.46e-44 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 153.89 E-value: 2.46e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 14 ESLSNMAITKPSAIQKACIPQIM-KGKDCIGGARTGSGKTIAFAAP----MLAEWSK-DPCGIFGLVLTPTRELAIQIAE 87
Cdd:cd17964 7 KALTRMGFETMTPVQQKTLKPILsTGDDVLARAKTGTGKTLAFLLPaiqsLLNTKPAgRRSGVSALIISPTRELALQIAA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 88 QFTALGANM-NIRVALIYGGVDMVKQSLELQKM-PHFVIATPGRLADHIRSSGedTIRGFRRVRYVVMDEADRLLTPGFV 165
Cdd:cd17964 87 EAKKLLQGLrKLRVQSAVGGTSRRAELNRLRRGrPDILVATPGRLIDHLENPG--VAKAFTDLDYLVLDEADRLLDMGFR 164
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 74659870 166 PDLKTCMDLLPDPS--KRQTLLFTATVTDAVRALKDRTGEKGPPFI 209
Cdd:cd17964 165 PDLEQILRHLPEKNadPRQTLLFSATVPDEVQQIARLTLKKDYKFI 210
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
1-229 |
9.32e-44 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 153.97 E-value: 9.32e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 1 MSFTDLGLPEWLNESLSNMAITKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPMLAEWSKDpcGIFG-------- 72
Cdd:cd18052 43 LTFEEANLCETLLKNIRKAGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPVLTGMMKE--GLTAssfsevqe 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 73 ---LVLTPTRELAIQI---AEQFTalgANMNIRVALIYGGVDMVKQSLELQKMPHFVIATPGRLADHIrssGEDTIrGFR 146
Cdd:cd18052 121 pqaLIVAPTRELANQIfleARKFS---YGTCIRPVVVYGGVSVGHQIRQIEKGCHILVATPGRLLDFI---GRGKI-SLS 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 147 RVRYVVMDEADRLLTPGFVPDLKTCMDLLPDPSK--RQTLLFTATVtdavralkdrtgekgPPFIHEIASDIavpstLTQ 224
Cdd:cd18052 194 KLKYLILDEADRMLDMGFGPEIRKLVSEPGMPSKedRQTLMFSATF---------------PEEIQRLAAEF-----LKE 253
|
....*
gi 74659870 225 SYLFL 229
Cdd:cd18052 254 DYLFL 258
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
17-201 |
1.46e-43 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 151.97 E-value: 1.46e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 17 SNMAITKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPMLAEWSKDPC------GIFGLVLTPTRELAIQIAEQFT 90
Cdd:cd17949 7 SKMGIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLLSLEPrvdrsdGTLALVLVPTRELALQIYEVLE 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 91 ALGANM-NIRVALIYGGVDMVKQSLELQKMPHFVIATPGRLADHIRSSgedtiRGFR--RVRYVVMDEADRLLTPGFVPD 167
Cdd:cd17949 87 KLLKPFhWIVPGYLIGGEKRKSEKARLRKGVNILIATPGRLLDHLKNT-----QSFDvsNLRWLVLDEADRLLDMGFEKD 161
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 74659870 168 LKTCMDLL-----------PDPSKRQTLLFTATVTDAVRALKDRT 201
Cdd:cd17949 162 ITKILELLddkrskaggekSKPSRRQTVLVSATLTDGVKRLAGLS 206
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
14-197 |
2.20e-42 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 148.29 E-value: 2.20e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 14 ESLSNMAITKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPMLAEWSKDPC-----GIFGLVLTPTRELAIQIAEQ 88
Cdd:cd17966 3 DELKRQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAIVHINAQPPlergdGPIVLVLAPTRELAQQIQQE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 89 FTALGANMNIRVALIYGGVDMVKQSLELQKMPHFVIATPGRLADhIRSSGEDTIrgfRRVRYVVMDEADRLLTPGFVPDL 168
Cdd:cd17966 83 ANKFGGSSRLRNTCVYGGAPKGPQIRDLRRGVEICIATPGRLID-FLDQGKTNL---RRVTYLVLDEADRMLDMGFEPQI 158
|
170 180 190
....*....|....*....|....*....|
gi 74659870 169 -KTCMDLLPDpskRQTLLFTATVTDAVRAL 197
Cdd:cd17966 159 rKIVDQIRPD---RQTLMWSATWPKEVRRL 185
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
21-224 |
4.85e-42 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 147.64 E-value: 4.85e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 21 ITKPSAIQKACIPQIMKG-KDCIGGARTGSGKTIAFAAPMLAEWSKDPCGIFgLVLTPTRELAIQIAEQFTALGANMNIR 99
Cdd:smart00487 6 FEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEALKRGKGGRV-LVLVPTRELAEQWAEELKKLGPSLGLK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 100 VALIYGGVDMVKQSLELQK-MPHFVIATPGRLADHIRSSGEDtirgFRRVRYVVMDEADRLLTPGFVPDLKTCMDLLpdP 178
Cdd:smart00487 85 VVGLYGGDSKREQLRKLESgKTDILVTTPGRLLDLLENDKLS----LSNVDLVILDEAHRLLDGGFGDQLEKLLKLL--P 158
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 74659870 179 SKRQTLLFTATVTDAVRALKDRTGEKgppfIHEIASDIAVPSTLTQ 224
Cdd:smart00487 159 KNVQLLLLSATPPEEIENLLELFLND----PVFIDVGFTPLEPIEQ 200
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
14-202 |
1.70e-41 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 146.18 E-value: 1.70e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 14 ESLSNMAITKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPML-------AEWSKDpcGIFGLVLTPTRELAIQI- 85
Cdd:cd17960 3 DVVAELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVLeillkrkANLKKG--QVGALIISPTRELATQIy 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 86 --AEQFTALGANmNIRVALIYGGVDMVKQ-SLELQKMPHFVIATPGRLADHIRSSGEdtIRGFRRVRYVVMDEADRLLTP 162
Cdd:cd17960 81 evLQSFLEHHLP-KLKCQLLIGGTNVEEDvKKFKRNGPNILVGTPGRLEELLSRKAD--KVKVKSLEVLVLDEADRLLDL 157
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 74659870 163 GFVPDLKTCMDLLpdPSKRQTLLFTATVTDAVRALKdRTG 202
Cdd:cd17960 158 GFEADLNRILSKL--PKQRRTGLFSATQTDAVEELI-KAG 194
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
12-197 |
3.30e-41 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 145.25 E-value: 3.30e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 12 LNESLSNMAITKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPMLAEWSKDPC-----GIFGLVLTPTRELAIQIA 86
Cdd:cd17952 1 LLNAIRKQEYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLVHIMDQRElekgeGPIAVIVAPTRELAQQIY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 87 EQFTALGANMNIRVALIYGGVDMVKQSLELQKMPHFVIATPGRLADHIRSSGEDtirgFRRVRYVVMDEADRLLTPGFVP 166
Cdd:cd17952 81 LEAKKFGKAYNLRVVAVYGGGSKWEQAKALQEGAEIVVATPGRLIDMVKKKATN----LQRVTYLVLDEADRMFDMGFEY 156
|
170 180 190
....*....|....*....|....*....|..
gi 74659870 167 DLKTCMD-LLPDpskRQTLLFTATVTDAVRAL 197
Cdd:cd17952 157 QVRSIVGhVRPD---RQTLLFSATFKKKIEQL 185
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
22-197 |
3.52e-41 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 145.13 E-value: 3.52e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 22 TKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPML-----AEWSKDPcGIFGLVLTPTRELAIQIAEQFTALGANM 96
Cdd:cd17941 11 IKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLeklyrERWTPED-GLGALIISPTRELAMQIFEVLRKVGKYH 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 97 NIRVALIYGGVDMVKQSLELQKMpHFVIATPGRLADHIRssgEDTIRGFRRVRYVVMDEADRLLTPGFVPDLKTCMDLLp 176
Cdd:cd17941 90 SFSAGLIIGGKDVKEEKERINRM-NILVCTPGRLLQHMD---ETPGFDTSNLQMLVLDEADRILDMGFKETLDAIVENL- 164
|
170 180
....*....|....*....|.
gi 74659870 177 dPSKRQTLLFTATVTDAVRAL 197
Cdd:cd17941 165 -PKSRQTLLFSATQTKSVKDL 184
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
2-189 |
1.41e-39 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 142.49 E-value: 1.41e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 2 SFTDLGLPEWLNESLSNMAITKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPMLAEWSKDPCG------------ 69
Cdd:cd18051 22 TFSDLDLGEIIRNNIELARYTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPILSQIYEQGPGeslpsesgyygr 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 70 ----IFGLVLTPTRELAIQIAEQFTALGANMNIRVALIYGGVDMVKQSLELQKMPHFVIATPGRLADHIrssgEDTIRGF 145
Cdd:cd18051 102 rkqyPLALVLAPTRELASQIYDEARKFAYRSRVRPCVVYGGADIGQQMRDLERGCHLLVATPGRLVDML----ERGKIGL 177
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 74659870 146 RRVRYVVMDEADRLLTPGFVPDLKTCM--DLLPDPSKRQTLLFTAT 189
Cdd:cd18051 178 DYCKYLVLDEADRMLDMGFEPQIRRIVeqDTMPPTGERQTLMFSAT 223
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
15-209 |
1.81e-38 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 137.88 E-value: 1.81e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 15 SLSNMAITKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPMLAEWSK----DPCGIFGLVLTPTRELAIQIAEQFT 90
Cdd:cd17942 4 AIEEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPAIELLYKlkfkPRNGTGVIIISPTRELALQIYGVAK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 91 ALGANMNIRVALIYGGVDMVKQSLELQKMPHFVIATPGRLADHIRSSGEDTirgFRRVRYVVMDEADRLLTPGFVPDLKT 170
Cdd:cd17942 84 ELLKYHSQTFGIVIGGANRKAEAEKLGKGVNILVATPGRLLDHLQNTKGFL---YKNLQCLIIDEADRILEIGFEEEMRQ 160
|
170 180 190
....*....|....*....|....*....|....*....
gi 74659870 171 CMDLLpdPSKRQTLLFTATVTDAVRALKDRTGEKGPPFI 209
Cdd:cd17942 161 IIKLL--PKRRQTMLFSATQTRKVEDLARISLKKKPLYV 197
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
16-197 |
9.43e-38 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 136.18 E-value: 9.43e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 16 LSNMA---ITKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPMLAEW--SKDPCGIFGLVLTPTRELAIQIAEQFT 90
Cdd:cd17957 2 LNNLEesgYREPTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQKLgkPRKKKGLRALILAPTRELASQIYRELL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 91 ALGANMNIRVALIYGGvDMVKQSLELQKMPHF--VIATPGRLADHIRSSGEDtirgFRRVRYVVMDEADRLLTPGFVPDL 168
Cdd:cd17957 82 KLSKGTGLRIVLLSKS-LEAKAKDGPKSITKYdiLVSTPLRLVFLLKQGPID----LSSVEYLVLDEADKLFEPGFREQT 156
|
170 180
....*....|....*....|....*....
gi 74659870 169 KTCMDLLPDPSKRQTlLFTATVTDAVRAL 197
Cdd:cd17957 157 DEILAACTNPNLQRS-LFSATIPSEVEEL 184
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
15-189 |
2.66e-37 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 135.16 E-value: 2.66e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 15 SLSNMAITKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPM----LAEWSKDPC----GIFGLVLTPTRELAIQ-- 84
Cdd:cd17951 4 GLKKKGIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPLimfaLEQEKKLPFikgeGPYGLIVCPSRELARQth 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 85 -IAEQFTAL---GANMNIRVALIYGGVDMVKQSLELQKMPHFVIATPGRLADHIrssgEDTIRGFRRVRYVVMDEADRLL 160
Cdd:cd17951 84 eVIEYYCKAlqeGGYPQLRCLLCIGGMSVKEQLEVIRKGVHIVVATPGRLMDML----NKKKINLDICRYLCLDEADRMI 159
|
170 180
....*....|....*....|....*....
gi 74659870 161 TPGFVPDLKTCMDLLpdPSKRQTLLFTAT 189
Cdd:cd17951 160 DMGFEEDIRTIFSYF--KGQRQTLLFSAT 186
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
15-198 |
6.32e-37 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 134.25 E-value: 6.32e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 15 SLSNMAITKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPML-------AEWSKDPcGIFGLVLTPTRELAIQIAE 87
Cdd:cd17961 8 AIAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIqkilkakAESGEEQ-GTRALILVPTRELAQQVSK 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 88 QFTALGANMN--IRVALIYGGVDMVKQSLELQKMPHFVIATPGRLADHIRSSgedTIRGFRRVRYVVMDEADRLLTPGFV 165
Cdd:cd17961 87 VLEQLTAYCRkdVRVVNLSASSSDSVQRALLAEKPDIVVSTPARLLSHLESG---SLLLLSTLKYLVIDEADLVLSYGYE 163
|
170 180 190
....*....|....*....|....*....|...
gi 74659870 166 PDLKTCMDLLpdPSKRQTLLFTATVTDAVRALK 198
Cdd:cd17961 164 EDLKSLLSYL--PKNYQTFLMSATLSEDVEALK 194
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
3-200 |
3.40e-36 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 132.04 E-value: 3.40e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 3 FTDLGLPEWLNESLSNMAITKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPMLAEWSKDPCGIFGLVLTPTRELA 82
Cdd:cd17940 1 FEDYGLKRELLMGIFEKGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIPILEKIDPKKDVIQALILVPTRELA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 83 IQIAEQFTALGANMNIRVALIYGGVDMVKQSLELQKMPHFVIATPGRLADHIRSSgedtIRGFRRVRYVVMDEADRLLTP 162
Cdd:cd17940 81 LQTSQVCKELGKHMGVKVMVTTGGTSLRDDIMRLYQTVHVLVGTPGRILDLAKKG----VADLSHCKTLVLDEADKLLSQ 156
|
170 180 190
....*....|....*....|....*....|....*...
gi 74659870 163 GFVPDLKTCMDLLpdPSKRQTLLFTATVTDAVRALKDR 200
Cdd:cd17940 157 DFQPIIEKILNFL--PKERQILLFSATFPLTVKNFMDR 192
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
23-194 |
3.21e-35 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 129.37 E-value: 3.21e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 23 KPSAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPMLAEWSKDPCGIFGLVLTPTRELAIQIAEQFTALGANMNIRVAL 102
Cdd:cd17939 19 KPSAIQQRAIVPIIKGRDVIAQAQSGTGKTATFSIGALQRIDTTVRETQALVLAPTRELAQQIQKVVKALGDYMGVKVHA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 103 IYGGVDMVKQSLELQKMPHFVIATPGRLADHIRSSGEDTirgfRRVRYVVMDEADRLLTPGFVPDLKTCMDLLpdPSKRQ 182
Cdd:cd17939 99 CIGGTSVREDRRKLQYGPHIVVGTPGRVFDMLQRRSLRT----DKIKMFVLDEADEMLSRGFKDQIYDIFQFL--PPETQ 172
|
170
....*....|..
gi 74659870 183 TLLFTATVTDAV 194
Cdd:cd17939 173 VVLFSATMPHEV 184
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
14-199 |
4.83e-35 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 128.74 E-value: 4.83e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 14 ESLSNMAITKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPMLAEWSKDPC------GIFGLVLTPTRELAIQIAE 87
Cdd:cd17958 3 KEIKKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPGFIHLDLQPIpreqrnGPGVLVLTPTRELALQIEA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 88 QFTALGANmNIRVALIYGGVDMVKQSLELQKMPHFVIATPGRLADHIRSSGEDtirgFRRVRYVVMDEADRLLTPGFVPD 167
Cdd:cd17958 83 ECSKYSYK-GLKSVCVYGGGNRNEQIEDLSKGVDIIIATPGRLNDLQMNNVIN----LKSITYLVLDEADRMLDMGFEPQ 157
|
170 180 190
....*....|....*....|....*....|...
gi 74659870 168 L-KTCMDLLPDpskRQTLLFTATVTDAVRALKD 199
Cdd:cd17958 158 IrKILLDIRPD---RQTIMTSATWPDGVRRLAQ 187
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
2-196 |
1.10e-33 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 125.54 E-value: 1.10e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 2 SFTDLGLPEWLNESLSNMAITKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPMLAEWSKDPCGIFGLVLTPTREL 81
Cdd:cd17950 3 GFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQQLEPVDGQVSVLVICHTREL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 82 AIQIAEQFTALGANM-NIRVALIYGGVDMVKQSLELQ-KMPHFVIATPGRLADHIRSSGEDTirgfRRVRYVVMDEADRL 159
Cdd:cd17950 83 AFQISNEYERFSKYMpNVKTAVFFGGVPIKKDIEVLKnKCPHIVVGTPGRILALVREKKLKL----SHVKHFVLDECDKM 158
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 74659870 160 LTpgfvpDLKTCMDL----LPDPSKRQTLLFTATVTDAVRA 196
Cdd:cd17950 159 LE-----QLDMRRDVqeifRATPHDKQVMMFSATLSKEIRP 194
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
1-199 |
3.22e-33 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 125.12 E-value: 3.22e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 1 MSFTDLGLPEWLNESLSNMAITKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPMLAEWSKDPC-----GIFGLVL 75
Cdd:cd18049 24 LNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFlergdGPICLVL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 76 TPTRELAIQIAEQFTALGANMNIRVALIYGGVDMVKQSLELQKMPHFVIATPGRLADHIRSSGEDtirgFRRVRYVVMDE 155
Cdd:cd18049 104 APTRELAQQVQQVAAEYGRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKTN----LRRCTYLVLDE 179
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 74659870 156 ADRLLTPGFVPDLKTCMDLL-PDpskRQTLLFTATVTDAVRALKD 199
Cdd:cd18049 180 ADRMLDMGFEPQIRKIVDQIrPD---RQTLMWSATWPKEVRQLAE 221
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
2-199 |
1.00e-31 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 122.04 E-value: 1.00e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 2 SFTDLGLPEWLNESLSNMAITKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPMLAEWSKDPC-----GIFGLVLT 76
Cdd:cd18050 63 AFHQANFPQYVMDVLLDQNFKEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQPYlergdGPICLVLA 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 77 PTRELAIQIAEQFTALGANMNIRVALIYGGVDMVKQSLELQKMPHFVIATPGRLADHIRSSGEDtirgFRRVRYVVMDEA 156
Cdd:cd18050 143 PTRELAQQVQQVADDYGKSSRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKTN----LRRCTYLVLDEA 218
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 74659870 157 DRLLTPGFVPDLKTCMD-LLPDpskRQTLLFTATVTDAVRALKD 199
Cdd:cd18050 219 DRMLDMGFEPQIRKIVDqIRPD---RQTLMWSATWPKEVRQLAE 259
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
12-191 |
1.56e-30 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 117.73 E-value: 1.56e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 12 LNESLSNMAITKPSAIQKACIPQIMKGKDCIGG---------ARTGSGKTIAFAAPMLAEWSKDP-CGIFGLVLTPTREL 81
Cdd:cd17956 1 LLKNLQNNGITSAFPVQAAVIPWLLPSSKSTPPyrpgdlcvsAPTGSGKTLAYVLPIVQALSKRVvPRLRALIVVPTKEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 82 AIQIAEQFTALGANMNIRVALIYGGVDMVKQSLELQKMPHF--------VIATPGRLADHIRSSgedtiRGF--RRVRYV 151
Cdd:cd17956 81 VQQVYKVFESLCKGTGLKVVSLSGQKSFKKEQKLLLVDTSGrylsrvdiLVATPGRLVDHLNST-----PGFtlKHLRFL 155
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 74659870 152 VMDEADRLL------------------TPGFVPDLKTCMDLLPDPSKRQTLLFTATVT 191
Cdd:cd17956 156 VIDEADRLLnqsfqdwletvmkalgrpTAPDLGSFGDANLLERSVRPLQKLLFSATLT 213
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
247-344 |
7.12e-30 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 111.92 E-value: 7.12e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 247 NEKKSAIIFVNRTQTAEtLRRMLMALDVKTASLHSEMRQQERVNALGRFRAQAARVLVATDVASRGLDIPTVEMVINFDL 326
Cdd:pfam00271 13 ERGGKVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLPDVDLVINYDL 91
|
90
....*....|....*...
gi 74659870 327 PADADDYIHRVGRTARAG 344
Cdd:pfam00271 92 PWNPASYIQRIGRAGRAG 109
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
3-194 |
9.93e-30 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 114.47 E-value: 9.93e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 3 FTDLGLPEWLNESLSNMAITKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPMLAEWSKDPCGIFGLVLTPTRELA 82
Cdd:cd18046 1 FDDMNLKESLLRGIYAYGFEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKTATFSISILQQIDTSLKATQALVLAPTRELA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 83 IQIAEQFTALGANMNIRVALIYGGVDMVKQSLELQKMPHFVIATPGRLADHIRssgedtiRGFRRVRYV---VMDEADRL 159
Cdd:cd18046 81 QQIQKVVMALGDYMGIKCHACIGGTSVRDDAQKLQAGPHIVVGTPGRVFDMIN-------RRYLRTDYIkmfVLDEADEM 153
|
170 180 190
....*....|....*....|....*....|....*
gi 74659870 160 LTPGFVPDLKTCMDLLpdPSKRQTLLFTATVTDAV 194
Cdd:cd18046 154 LSRGFKDQIYDIFQKL--PPDTQVVLLSATMPNDV 186
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
8-215 |
1.88e-29 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 113.82 E-value: 1.88e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 8 LPEWLNESLSNMAITKPSAIQKACIPQIMKG--KDCIGGARTGSGKTIAFAAPMLaewSK-DPCGIF--GLVLTPTRELA 82
Cdd:cd17963 1 LKPELLKGLYAMGFNKPSKIQETALPLILSDppENLIAQSQSGTGKTAAFVLAML---SRvDPTLKSpqALCLAPTRELA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 83 IQIAEQFTALGANMNIRVALIYGGVDmVKQSLELQKmpHFVIATPGRLADHIRSSGEDTirgfRRVRYVVMDEADRLL-T 161
Cdd:cd17963 78 RQIGEVVEKMGKFTGVKVALAVPGND-VPRGKKITA--QIVIGTPGTVLDWLKKRQLDL----KKIKILVLDEADVMLdT 150
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 74659870 162 PGFVPDLKTCMDLLPDPSkrQTLLFTATVTDAVRAlkdrtgekgppFIHEIASD 215
Cdd:cd17963 151 QGHGDQSIRIKRMLPRNC--QILLFSATFPDSVRK-----------FAEKIAPN 191
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
14-189 |
2.96e-29 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 113.13 E-value: 2.96e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 14 ESLSNMAITKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPMLAEWSKDPCGIFGLVLTPTRELAIQIAEQFTALG 93
Cdd:cd17943 3 EGLKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALESLDLERRHPQVLILAPTREIAVQIHDVFKKIG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 94 ANM-NIRVALIYGGVDmVKQSLELQKMPHFVIATPGRLA-----DHIRSSgedtirgfrRVRYVVMDEADRLLTPGFVPD 167
Cdd:cd17943 83 KKLeGLKCEVFIGGTP-VKEDKKKLKGCHIAVGTPGRIKqlielGALNVS---------HVRLFVLDEADKLMEGSFQKD 152
|
170 180
....*....|....*....|..
gi 74659870 168 LKTCMDLLpdPSKRQTLLFTAT 189
Cdd:cd17943 153 VNWIFSSL--PKNKQVIAFSAT 172
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
3-200 |
5.17e-29 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 112.80 E-value: 5.17e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 3 FTDLGL-PEwLNESLSNMAITKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPMLAEwskdpcgIFGLVLTPTREL 81
Cdd:cd17938 1 FEELGVmPE-LIKAVEELDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVLQI-------VVALILEPSREL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 82 AIQIAEQFTALGANMN---IRVALIYGGVDMVKQSLELQKMPHFVIATPGRLADHIRSSGEDtirgFRRVRYVVMDEADR 158
Cdd:cd17938 73 AEQTYNCIENFKKYLDnpkLRVALLIGGVKAREQLKRLESGVDIVVGTPGRLEDLIKTGKLD----LSSVRFFVLDEADR 148
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 74659870 159 LLTPGfvpDLKTCMDL---LP----DPSKRQTLLFTATV-TDAVRALKDR 200
Cdd:cd17938 149 LLSQG---NLETINRIynrIPkitsDGKRLQVIVCSATLhSFEVKKLADK 195
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
12-200 |
1.55e-26 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 105.71 E-value: 1.55e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 12 LNESLSNMAITKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPMLA---EWSKDPCgifGLVLTPTRELAIQIAEQ 88
Cdd:cd17962 1 LSSNLKKAGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIrclTEHRNPS---ALILTPTRELAVQIEDQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 89 FTALGANM-NIRVALIYGGVDMVKQSLELQKMPHFVIATPGRLADHIRssgEDTIRgFRRVRYVVMDEADRLLTPGFvpd 167
Cdd:cd17962 78 AKELMKGLpPMKTALLVGGLPLPPQLYRLQQGVKVIIATPGRLLDILK---QSSVE-LDNIKIVVVDEADTMLKMGF--- 150
|
170 180 190
....*....|....*....|....*....|....
gi 74659870 168 LKTCMDLLPD-PSKRQTLLFTATVTDAVRALKDR 200
Cdd:cd17962 151 QQQVLDILENiSHDHQTILVSATIPRGIEQLAGQ 184
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
12-165 |
3.91e-26 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 105.53 E-value: 3.91e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 12 LNESLSNMAITKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPM---LAEWSKDPCGIF----GLVLTPTRELAIQ 84
Cdd:cd17948 1 LVEILQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIiqrLLRYKLLAEGPFnaprGLVITPSRELAEQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 85 IAEQFTALGANMNIRVALIYGGVDMvkqslELQKMPHF-----VIATPGRLADHIRSSgedtIRGFRRVRYVVMDEADRL 159
Cdd:cd17948 81 IGSVAQSLTEGLGLKVKVITGGRTK-----RQIRNPHFeevdiLVATPGALSKLLTSR----IYSLEQLRHLVLDEADTL 151
|
....*.
gi 74659870 160 LTPGFV 165
Cdd:cd17948 152 LDDSFN 157
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
3-194 |
8.35e-26 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 103.70 E-value: 8.35e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 3 FTDLGLPEWLNESLSNMAITKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPMLAEWSKDPCGIFGLVLTPTRELA 82
Cdd:cd18045 1 FETMGLREDLLRGIYAYGFEKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSISVLQCLDIQVRETQALILSPTRELA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 83 IQIAEQFTALGANMNIRVALIYGGVDMVKQSLELQKMPHFVIATPGRLADHIRssgEDTIRgFRRVRYVVMDEADRLLTP 162
Cdd:cd18045 81 VQIQKVLLALGDYMNVQCHACIGGTSVGDDIRKLDYGQHIVSGTPGRVFDMIR---RRSLR-TRHIKMLVLDEADEMLNK 156
|
170 180 190
....*....|....*....|....*....|..
gi 74659870 163 GFVPDLKTCMDLLpdPSKRQTLLFTATVTDAV 194
Cdd:cd18045 157 GFKEQIYDVYRYL--PPATQVVLVSATLPQDI 186
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
263-344 |
1.10e-25 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 99.59 E-value: 1.10e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 263 ETLRRMLMALDVKTASLHSEMRQQERVNALGRFRAQAARVLVATDVASRGLDIPTVEMVINFDLPADADDYIHRVGRTAR 342
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGR 80
|
..
gi 74659870 343 AG 344
Cdd:smart00490 81 AG 82
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
27-194 |
6.39e-23 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 96.07 E-value: 6.39e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 27 IQKACIPQIMKGKDCIGGARTGSGKTIAFAAPMLAEWSKDPCGIFG------LVLTPTRELAIQIAEQFTALGANMNirV 100
Cdd:cd17944 16 IQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIEKLQEDQQPRKRgrapkvLVLAPTRELANQVTKDFKDITRKLS--V 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 101 ALIYGGVDMVKQSLELQKMPHFVIATPGRLADHIRSSGEDtirgFRRVRYVVMDEADRLLTPGFVPDLKtcmDLLPDPSK 180
Cdd:cd17944 94 ACFYGGTPYQQQIFAIRNGIDILVGTPGRIKDHLQNGRLD----LTKLKHVVLDEVDQMLDMGFAEQVE---EILSVSYK 166
|
170 180
....*....|....*....|
gi 74659870 181 R------QTLLFTATVTDAV 194
Cdd:cd17944 167 KdsednpQTLLFSATCPDWV 186
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
47-442 |
3.06e-20 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 93.17 E-value: 3.06e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 47 TGSGKTIAFAAPMLAEWSKDPCgifgLVLTPTRELAIQIAEQFTALganmnIRVALIYGGvdmvkqslELQKMPHFVIAT 126
Cdd:COG1061 109 TGTGKTVLALALAAELLRGKRV----LVLVPRRELLEQWAEELRRF-----LGDPLAGGG--------KKDSDAPITVAT 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 127 PGRLADHIRssgEDTIRgfRRVRYVVMDEADRLLTPGFvpdlKTCMDLLPdPSKRqtLLFTATV--TDAVRALKDRTGEK 204
Cdd:COG1061 172 YQSLARRAH---LDELG--DRFGLVIIDEAHHAGAPSY----RRILEAFP-AAYR--LGLTATPfrSDGREILLFLFDGI 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 205 ---------------GPPFIHEIASDIavpSTLTQSYLFLPGYVREAYL------WAILT-----HPDNEKksAIIFVNR 258
Cdd:COG1061 240 vyeyslkeaiedgylAPPEYYGIRVDL---TDERAEYDALSERLREALAadaerkDKILRellreHPDDRK--TLVFCSS 314
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 259 TQTAETLRRMLMALDVKTASLHSEMRQQERVNALGRFRAQAARVLVATDVASRGLDIPTVEMVINFDLPADADDYIHRVG 338
Cdd:COG1061 315 VDHAEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELRILVTVDVLNEGVDVPRLDVAILLRPTGSPREFIQRLG 394
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 339 RTARAGRKGQSVS---LVTERDVTRVTNIEERVGTKMEKYDLIEDDKVVEEYLTPASTAKRQAVLDMEAENFGERKRIQR 415
Cdd:COG1061 395 RGLRPAPGKEDALvydFVGNDVPVLEELAKDLRDLAGYRVEFLDEEESEELALLIAVKPALEVKGELEEELLEELELLED 474
|
410 420
....*....|....*....|....*..
gi 74659870 416 KKAGLDVDMKSKNKKPKRVAKGKSDKK 442
Cdd:COG1061 475 ALLLVLAELLLLELLALALELLELAKA 501
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
247-436 |
1.74e-15 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 78.62 E-value: 1.74e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 247 NEKKSAIIFVNRTQTAETLRRMLMALDVKT------ASLHSE--MRQQERVNALGRFRAQAARVLVATDVASRGLDIPTV 318
Cdd:COG1111 351 NPDSRIIVFTQYRDTAEMIVEFLSEPGIKAgrfvgqASKEGDkgLTQKEQIEILERFRAGEFNVLVATSVAEEGLDIPEV 430
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 319 EMVINFDLPADADDYIHRVGRTARaGRKGQSVSLVTE--RDvTRVTNIEERVGTKMEKyDLIEDDKVVEEYLTPASTAKR 396
Cdd:COG1111 431 DLVIFYEPVPSEIRSIQRKGRTGR-KREGRVVVLIAKgtRD-EAYYWSSRRKEKKMKS-ILKKLKKLLDKQEKEKLKESA 507
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 74659870 397 QAVLDmEAENFGERKRIQRKKAGLDVDMKSKNKKPKRVAK 436
Cdd:COG1111 508 QATLD-EFESIKELAEDEINEKDLDEIESSENGAHVDWRE 546
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
38-189 |
5.83e-15 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 71.67 E-value: 5.83e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 38 GKDCIGGARTGSGKTIAFAAPMLAEWSKDPCGIfgLVLTPTRELAIQIAEQFTALgANMNIRVALIYGGVDMVKQSLELQ 117
Cdd:cd00046 1 GENVLITAPTGSGKTLAALLAALLLLLKKGKKV--LVLVPTKALALQTAERLREL-FGPGIRVAVLVGGSSAEEREKNKL 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 74659870 118 KMPHFVIATPGRLADHIRSSGEdtiRGFRRVRYVVMDEADRLLTPGFVPDLKTCMDLLPDPSKRQTLLFTAT 189
Cdd:cd00046 78 GDADIIIATPDMLLNLLLREDR---LFLKDLKLIIVDEAHALLIDSRGALILDLAVRKAGLKNAQVILLSAT 146
|
|
| SF2_C_dicer |
cd18802 |
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ... |
243-343 |
1.35e-14 |
|
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350189 [Multi-domain] Cd Length: 142 Bit Score: 70.70 E-value: 1.35e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 243 THPDNEKKSAIIFVNRTQTAETLRRML-----------------MALDVKTASLHSEMRQQERVnaLGRFRAQAARVLVA 305
Cdd:cd18802 19 YFPKTPDFRGIIFVERRATAVVLSRLLkehpstlafircgfligRGNSSQRKRSLMTQRKQKET--LDKFRDGELNLLIA 96
|
90 100 110
....*....|....*....|....*....|....*...
gi 74659870 306 TDVASRGLDIPTVEMVINFDLPADADDYIHRVGRtARA 343
Cdd:cd18802 97 TSVLEEGIDVPACNLVIRFDLPKTLRSYIQSRGR-ARA 133
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
247-357 |
4.01e-14 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 74.52 E-value: 4.01e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 247 NEKKSAIIFVNRTQTAETLRRMLMALDVKT------ASLHSE--MRQQERVNALGRFRAQAARVLVATDVASRGLDIPTV 318
Cdd:PRK13766 363 NPDSRIIVFTQYRDTAEKIVDLLEKEGIKAvrfvgqASKDGDkgMSQKEQIEILDKFRAGEFNVLVSTSVAEEGLDIPSV 442
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 74659870 319 EMVINFDLPADADDYIHRVGRTARaGRKGQSVSLVTE--RD 357
Cdd:PRK13766 443 DLVIFYEPVPSEIRSIQRKGRTGR-QEEGRVVVLIAKgtRD 482
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
12-190 |
9.00e-14 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 70.87 E-value: 9.00e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 12 LNESLSNMAITKPSAIQKACIPQIMK---------GKDCIGG-------ARTGSGKTIAFAAPML-------AEWS---- 64
Cdd:cd17965 19 LKGSNKTDEEIKPSPIQTLAIKKLLKtlmrkvtkqTSNEEPKlevfllaAETGSGKTLAYLAPLLdylkrqeQEPFeeae 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 65 ------KDPCGIFGLVLTPTRELAIQIAEQFTALGANMNIRVALIYGGVD-MVKQSLELQKMP-HFVIATPGRLAdhirS 136
Cdd:cd17965 99 eeyesaKDTGRPRSVILVPTHELVEQVYSVLKKLSHTVKLGIKTFSSGFGpSYQRLQLAFKGRiDILVTTPGKLA----S 174
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 74659870 137 SGEDTIRGFRRVRYVVMDEADRLLTPGFVPDLKTCMDLLPDpsKRQTLLFTATV 190
Cdd:cd17965 175 LAKSRPKILSRVTHLVVDEADTLFDRSFLQDTTSIIKRAPK--LKHLILCSATI 226
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
2-200 |
3.66e-13 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 68.51 E-value: 3.66e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 2 SFTDLGLPEWLNESLSNMAITKPSAIQKACIPQIMKG--KDCIGGARTGSGKTIAFAAPMLAEWSKDPCGIFGLVLTPTR 79
Cdd:cd18048 19 SFEELHLKEELLRGIYAMGFNRPSKIQENALPMMLADppQNLIAQSQSGTGKTAAFVLAMLSRVDALKLYPQCLCLSPTF 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 80 ELAIQ---IAEQFTALGANMNIRVAL----IYGGVDMVKQslelqkmphFVIATPGRLAD---HIRSSGEDTIRGFrrvr 149
Cdd:cd18048 99 ELALQtgkVVEEMGKFCVGIQVIYAIrgnrPGKGTDIEAQ---------IVIGTPGTVLDwcfKLRLIDVTNISVF---- 165
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 74659870 150 yvVMDEADRLL-TPGFVPD---LKTCMdllpdPSKRQTLLFTATVTDAVRALKDR 200
Cdd:cd18048 166 --VLDEADVMInVQGHSDHsvrVKRSM-----PKECQMLLFSATFEDSVWAFAER 213
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
8-156 |
1.38e-12 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 69.86 E-value: 1.38e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 8 LPEWLNES----LSNMAITKPSAIQKACIPQIMKGKDCIGGARTGSGKTIAFAAPMLAEWSKDPcGIFGLVLTPTRELAi 83
Cdd:COG1205 37 WPDWLPPElraaLKKRGIERLYSHQAEAIEAARAGKNVVIATPTASGKSLAYLLPVLEALLEDP-GATALYLYPTKALA- 114
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 74659870 84 qiAEQFTAL-----GANMNIRVALIYGGVDMVKQSlELQKMPHFVIATPGRLADHIRSSGEDTIRGFRRVRYVVMDEA 156
Cdd:COG1205 115 --RDQLRRLrelaeALGLGVRVATYDGDTPPEERR-WIREHPDIVLTNPDMLHYGLLPHHTRWARFFRNLRYVVIDEA 189
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
28-358 |
7.42e-12 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 67.09 E-value: 7.42e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 28 QKACIPQIMKGKDCIGGARTGSGKTIAF--AAPMLAewskdpcGIfGLVLTPtreLaiqIA------EQFTALGanmnIR 99
Cdd:COG0514 22 QEEIIEAVLAGRDALVVMPTGGGKSLCYqlPALLLP-------GL-TLVVSP---L---IAlmkdqvDALRAAG----IR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 100 VALIYGGVDM-----VKQSLELQKMpHFVIATPGRLADhirssgEDTIRGFRRVR--YVVMDEA--------DrlltpgF 164
Cdd:COG0514 84 AAFLNSSLSAeerreVLRALRAGEL-KLLYVAPERLLN------PRFLELLRRLKisLFAIDEAhcisqwghD------F 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 165 VPD---LKTCMDLLPDPskrQTLLFTATVTDAVRAlkdrtgekgppfihEIAS--DIAVPSTLTQS-------YLFLPGY 232
Cdd:COG0514 151 RPDyrrLGELRERLPNV---PVLALTATATPRVRA--------------DIAEqlGLEDPRVFVGSfdrpnlrLEVVPKP 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 233 VREAYLWaILTH-PDNEKKSAIIFVNRTQTAETLRRMLMALDVKTASLHSEMRQQERVNALGRFRAQAARVLVATdVA-S 310
Cdd:COG0514 214 PDDKLAQ-LLDFlKEHPGGSGIVYCLSRKKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEVDVIVAT-IAfG 291
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 74659870 311 RGLDIPTVEMVINFDLPADADDYIHRVGRTARAGRKGQSVSLVTERDV 358
Cdd:COG0514 292 MGIDKPDVRFVIHYDLPKSIEAYYQEIGRAGRDGLPAEALLLYGPEDV 339
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
252-352 |
1.44e-11 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 61.99 E-value: 1.44e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 252 AIIFVNRTQTAETLRRMLMAL-------------DVKTASLHSEMRQQErvnALGRFRAQAARVLVATDVASRGLDIPTV 318
Cdd:cd18801 33 VIIFSEFRDSAEEIVNFLSKIrpgiratrfigqaSGKSSKGMSQKEQKE---VIEQFRKGGYNVLVATSIGEEGLDIGEV 109
|
90 100 110
....*....|....*....|....*....|....
gi 74659870 319 EMVINFDLPADADDYIHRVGRTARaGRKGQSVSL 352
Cdd:cd18801 110 DLIICYDASPSPIRMIQRMGRTGR-KRQGRVVVL 142
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
44-156 |
5.47e-11 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 61.12 E-value: 5.47e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 44 GARTGSGKT-IAFAApMLAEWSKDPCGIfgLVLTPTRELAIQIAEQFTALGANMNIRVALIYGgvDMVKQSLELQKmPHF 122
Cdd:cd17921 23 SAPTSSGKTlIAELA-ILRALATSGGKA--VYIAPTRALVNQKEADLRERFGPLGKNVGLLTG--DPSVNKLLLAE-ADI 96
|
90 100 110
....*....|....*....|....*....|....
gi 74659870 123 VIATPGRLADHIRSSGEdtiRGFRRVRYVVMDEA 156
Cdd:cd17921 97 LVATPEKLDLLLRNGGE---RLIQDVRLVVVDEA 127
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
2-200 |
2.00e-10 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 60.12 E-value: 2.00e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 2 SFTDLGLPEWLNESLSNMAITKPSAIQKACIPQIMKG--KDCIGGARTGSGKTIAFAAPMLA------EWSKDPCgifgl 73
Cdd:cd18047 2 SFEELRLKPQLLQGVYAMGFNRPSKIQENALPLMLAEppQNLIAQSQSGTGKTAAFVLAMLSqvepanKYPQCLC----- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 74 vLTPTRELAIQIAEQFTALGaNMNIRVALIYgGVDMVKQSLELQKMPHFVIATPGRLADH-IRSSGEDTirgfRRVRYVV 152
Cdd:cd18047 77 -LSPTYELALQTGKVIEQMG-KFYPELKLAY-AVRGNKLERGQKISEQIVIGTPGTVLDWcSKLKFIDP----KKIKVFV 149
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 74659870 153 MDEADRLL-TPGFVPDLKTCMDLLPDPSkrQTLLFTATVTDAVRALKDR 200
Cdd:cd18047 150 LDEADVMIaTQGHQDQSIRIQRMLPRNC--QMLLFSATFEDSVWKFAQK 196
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
250-348 |
6.92e-10 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 56.83 E-value: 6.92e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 250 KSAIIFVNRTQTAETLRRMLMALDVKTASLHSEMRQQERVNALGRFRAQAARVLVATDVASRGLDIPTVEMVINFDLPAD 329
Cdd:cd18794 31 GSGIIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLRDKIQVIVATVAFGMGIDKPDVRFVIHYSLPKS 110
|
90
....*....|....*....
gi 74659870 330 ADDYIHRVGrtaRAGRKGQ 348
Cdd:cd18794 111 MESYYQESG---RAGRDGL 126
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
247-338 |
2.04e-09 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 55.56 E-value: 2.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 247 NEKksAIIFVNRTQTAETLRRMLMALDVKTASLHSEMRQQERVNALGRFRA--QAARVLVATDVASRGLDIPTVEMVINF 324
Cdd:cd18793 27 GEK--VLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEdpDIRVFLLSTKAGGVGLNLTAANRVILY 104
|
90 100
....*....|....*....|
gi 74659870 325 DL---PAD---ADDYIHRVG 338
Cdd:cd18793 105 DPwwnPAVeeqAIDRAHRIG 124
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
252-344 |
1.17e-08 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 51.55 E-value: 1.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 252 AIIFVNRTQTAETLRRMLmaldvktaslhsemrqqervnalgrfraqaaRVLVATDVASRGLDIPTVEMVINFDLPADAD 331
Cdd:cd18785 6 IIVFTNSIEHAEEIASSL-------------------------------EILVATNVLGEGIDVPSLDTVIFFDPPSSAA 54
|
90
....*....|...
gi 74659870 332 DYIHRVGRTARAG 344
Cdd:cd18785 55 SYIQRVGRAGRGG 67
|
|
| DEXHc_RecQ |
cd17920 |
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ... |
28-196 |
1.34e-07 |
|
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.
Pssm-ID: 350678 [Multi-domain] Cd Length: 200 Bit Score: 51.77 E-value: 1.34e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 28 QKACIPQIMKGKDCIGGARTGSGKTIAFAAPMLAEwskDPCGIfglVLTPTRELaiqIAEQFTALgANMNIRVALIYGGV 107
Cdd:cd17920 17 QLEAINAVLAGRDVLVVMPTGGGKSLCYQLPALLL---DGVTL---VVSPLISL---MQDQVDRL-QQLGIRAAALNSTL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 108 DMVKQSLELQKMP----HFVIATPGRLA-DHIRSSgEDTIRGFRRVRYVVMDEADRLLTPG--FVPD---LKTCMDLLPD 177
Cdd:cd17920 87 SPEEKREVLLRIKngqyKLLYVTPERLLsPDFLEL-LQRLPERKRLALIVVDEAHCVSQWGhdFRPDylrLGRLRRALPG 165
|
170
....*....|....*....
gi 74659870 178 PskrQTLLFTATVTDAVRA 196
Cdd:cd17920 166 V---PILALTATATPEVRE 181
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
38-155 |
3.70e-07 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 49.89 E-value: 3.70e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 38 GKDCIGGARTGSGKTIAFAAPMLAEWSKDPC-GIFGLVLTPTRELaiqIAEQFTAL-----GANMNIRVALIYGGVDMVK 111
Cdd:cd17922 1 GRNVLIAAPTGSGKTEAAFLPALSSLADEPEkGVQVLYISPLKAL---INDQERRLeepldEIDLEIPVAVRHGDTSQSE 77
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 74659870 112 QSLELQKMPHFVIATPGRLadHIRSSGEDTIRGFRRVRYVVMDE 155
Cdd:cd17922 78 KAKQLKNPPGILITTPESL--ELLLVNKKLRELFAGLRYVVVDE 119
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
248-380 |
8.12e-07 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 51.38 E-value: 8.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 248 EKKSAIIFVNRTQTAETLRRMLMALDVKTASLHSEMRQQERVNALGRFRAQ--AARVLVATDVASRGLDIPTVEMVINFD 325
Cdd:COG0553 548 EGEKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGpeAPVFLISLKAGGEGLNLTAADHVIHYD 627
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 74659870 326 L---PADADDyihrvgRTARAGRKGQsvslvtERDVTrVTN------IEERV-GTKMEKYDLIED 380
Cdd:COG0553 628 LwwnPAVEEQ------AIDRAHRIGQ------TRDVQ-VYKlvaegtIEEKIlELLEEKRALAES 679
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
26-156 |
1.42e-06 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 48.35 E-value: 1.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 26 AIQKACipqimKGKDCIGGARTGSGKTIAFAAPMLAEWSKDPcGIFGLVLTPTRELAIQIAEQFTALGANM--NIRVALI 103
Cdd:cd17923 8 AIEAAR-----AGRSVVVTTGTASGKSLCYQLPILEALLRDP-GSRALYLYPTKALAQDQLRSLRELLEQLglGIRVATY 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 74659870 104 YGGVDMVKQSLELQKMPHFVIATPGRLadH---IRSSGEDtIRGFRRVRYVVMDEA 156
Cdd:cd17923 82 DGDTPREERRAIIRNPPRILLTNPDML--HyalLPHHDRW-ARFLRNLRYVVLDEA 134
|
|
| SF2_C_UvrB |
cd18790 |
C-terminal helicase domain of the UvrB family helicases; Excinuclease ABC subunit B (or UvrB) ... |
262-342 |
1.19e-05 |
|
C-terminal helicase domain of the UvrB family helicases; Excinuclease ABC subunit B (or UvrB) plays a central role in nucleotide excision repair (NER). Together with other components of the NER system, like UvrA, UvrC, UvrD (helicase II), and DNA polymerase I, it recognizes and cleaves damaged DNA in a multistep ATP-dependent reaction. UvrB is critical for the second phase of damage recognition by verifying the nature of the damage and forming the pre-incision complex. Its ATPase site becomes activated in the presence of UvrA and damaged DNA. Its activity is strand destabilization via distortion of the DNA at lesion site, with very limited DNA unwinding. UvrB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350177 [Multi-domain] Cd Length: 171 Bit Score: 45.31 E-value: 1.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 262 AETLRRMLMALDVKTASLHSEMRQQERVNALGRFRAQAARVLVATDVASRGLDIPTVEMVINFDlpADADDY-------I 334
Cdd:cd18790 40 AEDLTEYLQELGVKVRYLHSEIDTLERVEIIRDLRLGEFDVLVGINLLREGLDLPEVSLVAILD--ADKEGFlrsetslI 117
|
....*...
gi 74659870 335 HRVGRTAR 342
Cdd:cd18790 118 QTIGRAAR 125
|
|
| Cas3_I |
cd09639 |
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short ... |
247-387 |
2.27e-05 |
|
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I
Pssm-ID: 187770 [Multi-domain] Cd Length: 353 Bit Score: 46.27 E-value: 2.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 247 NEKKSAIIFVNRTQTAETLRRMLMAL--DVKTASLHSEMRQQERVNA----LGRFRAQAARVLVATDVASRGLDIptvem 320
Cdd:cd09639 216 KKGGSVAIIVNTVDRAQEFYQQLKEKgpEEEIMLIHSRFTEKDRAKKeaelLLEFKKSEKFVIVATQVIEASLDI----- 290
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 74659870 321 viNFDL----PADADDYIHRVGRTARAGRKgqsvslvTERDVTRVTNIEERVGTKMEKYDLIED-DKVVEEY 387
Cdd:cd09639 291 --SVDVmiteLAPIDSLIQRLGRLHRYGEK-------NGEEVYIITDAPDGKGQKPYPYDLVERtIELLEEG 353
|
|
| SF2_C_EcoAI-like |
cd18799 |
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family ... |
248-322 |
2.84e-05 |
|
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family is composed of helicase restriction enzymes, including the HsdR subunit of restriction-modification enzymes such as Escherichia coli type I restriction enzyme EcoAI R protein (R.EcoAI). The EcoAI enzyme recognizes 5'-GAGN(7)GTCA-3'. The HsdR or R subunit is required for both nuclease and ATPase activities, but not for modification. These proteins are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350186 [Multi-domain] Cd Length: 116 Bit Score: 43.32 E-value: 2.84e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 74659870 248 EKKSAIIFVNRTQTAETLRRMLMALDVKTASLHSEMRQQER-VNALGRFRAQ--AARVLVATDVASRGLDIPTVEMVI 322
Cdd:cd18799 5 VEIKTLIFCVSIEHAEFMAEAFNEAGIDAVALNSDYSDRERgDEALILLFFGelKPPILVTVDLLTTGVDIPEVDNVV 82
|
|
| uvrb |
TIGR00631 |
excinuclease ABC, B subunit; All proteins in this family for wich functions are known are DNA ... |
262-436 |
2.84e-05 |
|
excinuclease ABC, B subunit; All proteins in this family for wich functions are known are DNA helicases that function in the nucleotide excision repair and are endonucleases that make the 3' incision next to DNA damage. They are part of a pathway requiring UvrA, UvrB, UvrC, and UvrD homologs. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University) [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273185 [Multi-domain] Cd Length: 655 Bit Score: 46.52 E-value: 2.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 262 AETLRRMLMALDVKTASLHSEMRQQERVNALGRFRAQAARVLVATDVASRGLDIPTVEMVINFDlpADADDY-------I 334
Cdd:TIGR00631 455 AEDLTDYLKELGIKVRYLHSEIDTLERVEIIRDLRLGEFDVLVGINLLREGLDLPEVSLVAILD--ADKEGFlrserslI 532
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 335 HRVGRTARAGRkGQSV---SLVTErDVTRVTNIEERVGTKMEKYDLieddkvvEEYLTPASTAKR-QAVLDMEAENfgER 410
Cdd:TIGR00631 533 QTIGRAARNVN-GKVImyaDKITD-SMQKAIEETERRRKIQMAYNE-------EHGITPQTIRKPiRDILDIELKE--KE 601
|
170 180
....*....|....*....|....*.
gi 74659870 411 KRIQRKKAGLDVDMKSKNKKPKRVAK 436
Cdd:TIGR00631 602 DAAKKKKKGEDLSDLSKKELKKLIKQ 627
|
|
| SF2_C_TRCF |
cd18810 |
C-terminal helicase domain of the transcription-repair coupling factor; Transcription-repair ... |
256-366 |
3.83e-05 |
|
C-terminal helicase domain of the transcription-repair coupling factor; Transcription-repair coupling factor (TrcF) dissociates transcription elongation complexes blocked at nonpairing lesions and mediates recruitment of DNA repair proteins. TrcF is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350197 [Multi-domain] Cd Length: 151 Bit Score: 43.49 E-value: 3.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 256 VNRTQTAETLRRMLMAL--DVKTASLHSEMRQQERVNALGRFRAQAARVLVATDVASRGLDIPTVEMVINFDlpAD---- 329
Cdd:cd18810 32 HNRIESIEKLATQLRQLvpEARIAIAHGQMTENELEEVMLEFAKGEYDILVCTTIIESGIDIPNANTIIIER--ADkfgl 109
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 74659870 330 ADDYIHRvGRTARAGRKGQSVSLV------TERDVTRVTNIEE 366
Cdd:cd18810 110 AQLYQLR-GRVGRSKERAYAYFLYpdqkklTEDALKRLEAIQE 151
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
47-189 |
4.47e-05 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 43.45 E-value: 4.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 47 TGSGKT-IAFAAPmlAEWSKDPCgifgLVLTPTRELAIQIAEQFTALgaNMNIRVALIYGGVDMVKQSLELqkmphfVIA 125
Cdd:cd17926 27 TGSGKTlTALALI--AYLKELRT----LIVVPTDALLDQWKERFEDF--LGDSSIGLIGGGKKKDFDDANV------VVA 92
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 74659870 126 TPgrlaDHIRSSGEDTIRGFRRVRYVVMDEADRLLTPGFVpdlktcmDLLPDPSKRQTLLFTAT 189
Cdd:cd17926 93 TY----QSLSNLAEEEKDLFDQFGLLIVDEAHHLPAKTFS-------EILKELNAKYRLGLTAT 145
|
|
| SF2_C_XPB |
cd18789 |
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex ... |
244-348 |
4.82e-05 |
|
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex helicase XPB (xeroderma pigmentosum type B) subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350176 [Multi-domain] Cd Length: 153 Bit Score: 43.39 E-value: 4.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 244 HPDNEKksAIIFvnrTQTAETLRRMlmALDVKTASLHSEMRQQERVNALGRFRAQAARVLVATDVASRGLDIP--TVEMV 321
Cdd:cd18789 46 HEQGDK--IIVF---TDNVEALYRY--AKRLLKPFITGETPQSEREEILQNFREGEYNTLVVSKVGDEGIDLPeaNVAIQ 118
|
90 100
....*....|....*....|....*..
gi 74659870 322 INFdLPADADDYIHRVGRTARAGRKGQ 348
Cdd:cd18789 119 ISG-HGGSRRQEAQRLGRILRPKKGGG 144
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
250-347 |
4.99e-05 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 45.47 E-value: 4.99e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 250 KSAIIFVNRTQTAETLRRMLMALDVKTASLHSEMRQQERVNALGRFRAQAARVLVATDVASRGLDIPTVEMVINFDLPAD 329
Cdd:PRK11057 237 KSGIIYCNSRAKVEDTAARLQSRGISAAAYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGMGINKPNVRFVVHFDIPRN 316
|
90
....*....|....*...
gi 74659870 330 ADDYIHrvgRTARAGRKG 347
Cdd:PRK11057 317 IESYYQ---ETGRAGRDG 331
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
26-155 |
6.62e-05 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 43.88 E-value: 6.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 26 AIQKACIPQIMKG-KDCIGGARTGSGKTIAFAAPMLAEWSKDPCGIFGLVLT----PTRELAIQIAEQFTALGANMNIRV 100
Cdd:cd18023 4 RIQSEVFPDLLYSdKNFVVSAPTGSGKTVLFELAILRLLKERNPLPWGNRKVvyiaPIKALCSEKYDDWKEKFGPLGLSC 83
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 74659870 101 ALIYGGVDMvKQSLELQKMpHFVIATPGRLaDHIRSSGEDTIRGFRRVRYVVMDE 155
Cdd:cd18023 84 AELTGDTEM-DDTFEIQDA-DIILTTPEKW-DSMTRRWRDNGNLVQLVALVLIDE 135
|
|
| SF2_C_RecG_TRCF |
cd18792 |
C-terminal helicase domain of the RecG family helicases; The DEAD-like helicase RecG family ... |
244-344 |
1.45e-04 |
|
C-terminal helicase domain of the RecG family helicases; The DEAD-like helicase RecG family contains recombination factor RecG and transcription-repair coupling factor TrcF. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350179 [Multi-domain] Cd Length: 160 Bit Score: 42.25 E-value: 1.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 244 HPDNEKKSAIIFVNRTQTAETLRRMLMalDVKTASLHSEMRQQERVNALGRFRAQAARVLVATDVASRGLDIPTVE-MVI 322
Cdd:cd18792 33 YPRIEESEKLDLKSIEALAEELKELVP--EARVALLHGKMTEDEKEAVMLEFREGEYDILVSTTVIEVGIDVPNANtMII 110
|
90 100 110
....*....|....*....|....*....|
gi 74659870 323 NfdlpaDADDY----IH----RVGRTARAG 344
Cdd:cd18792 111 E-----DADRFglsqLHqlrgRVGRGKHQS 135
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
47-189 |
2.23e-04 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 41.50 E-value: 2.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 47 TGSGKTIAFAAPMLAEWSKDPCGIFgLVLTPTRELAIQIAEQFTALGANMNIRVALIYGGvdmvKQSLELQKMPHFVIaT 126
Cdd:pfam04851 32 TGSGKTLTAAKLIARLFKKGPIKKV-LFLVPRKDLLEQALEEFKKFLPNYVEIGEIISGD----KKDESVDDNKIVVT-T 105
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 74659870 127 PGRLADHIRSSGEDTIRGFRRVryVVMDEADRLLTPGFvpdlKTCMDLLPDPskrqTLL-FTAT 189
Cdd:pfam04851 106 IQSLYKALELASLELLPDFFDV--IIIDEAHRSGASSY----RNILEYFKPA----FLLgLTAT 159
|
|
| PRK13767 |
PRK13767 |
ATP-dependent helicase; Provisional |
28-155 |
2.85e-04 |
|
ATP-dependent helicase; Provisional
Pssm-ID: 237497 [Multi-domain] Cd Length: 876 Bit Score: 43.34 E-value: 2.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 28 QKACIPQIMKGKDCIGGARTGSGKTI-AFAAPM-----LAEWSKDPCGIFGLVLTPTRELA--IQ---------IAEQFT 90
Cdd:PRK13767 37 QRYAIPLIHEGKNVLISSPTGSGKTLaAFLAIIdelfrLGREGELEDKVYCLYVSPLRALNndIHrnleeplteIREIAK 116
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 74659870 91 ALGANM-NIRVALIYGGVDmvkqSLELQKM----PHFVIATPGRLADHIRSSgedtirGFRR----VRYVVMDE 155
Cdd:PRK13767 117 ERGEELpEIRVAIRTGDTS----SYEKQKMlkkpPHILITTPESLAILLNSP------KFREklrtVKWVIVDE 180
|
|
| DEXHc_RecQ4-like |
cd18018 |
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) ... |
28-221 |
1.41e-03 |
|
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations cause Rothmund-Thomson/RAPADILINO/Baller-Gerold syndrome.
Pssm-ID: 350776 [Multi-domain] Cd Length: 201 Bit Score: 39.93 E-value: 1.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 28 QKACIPQIMKGKDCIGGARTGSGKTIAFAAPMLAEWSKDPCgiFGLVLTPTRELaiqIAEQFTALGAnmNIRVALIYGGV 107
Cdd:cd18018 17 QEEAIARLLSGRSTLVVLPTGAGKSLCYQLPALLLRRRGPG--LTLVVSPLIAL---MKDQVDALPR--AIKAAALNSSL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 108 DMVKQSLELQKMP----HFVIATPGRLADhirSSGEDTIRGFRRVRYVVMDEADRLLTPG--FVPD-LKTCMDLLPDPSK 180
Cdd:cd18018 90 TREERRRILEKLRagevKILYVSPERLVN---ESFRELLRQTPPISLLVVDEAHCISEWShnFRPDyLRLCRVLRELLGA 166
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 74659870 181 RQTLLFTATVTDAVralkdrtgekgppfIHEIASDIAVPST 221
Cdd:cd18018 167 PPVLALTATATKRV--------------VEDIASHLGIPES 193
|
|
| DEXHc_RecG |
cd17992 |
DEXH/Q-box helicase domain of RecG; ATP-dependent DNA helicase RecG plays a critical role in ... |
48-168 |
2.75e-03 |
|
DEXH/Q-box helicase domain of RecG; ATP-dependent DNA helicase RecG plays a critical role in recombination and DNA repair. It is a member of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350750 [Multi-domain] Cd Length: 225 Bit Score: 39.05 E-value: 2.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 48 GSGKTI-AFAAPMLAEWSkdpcGIFGLVLTPTRELAIQIAEQFTALGANMNIRVALIYGGV-----DMVKQSLELQKmPH 121
Cdd:cd17992 76 GSGKTVvAALAMLAAVEN----GYQVALMAPTEILAEQHYDSLKKLLEPLGIRVALLTGSTkakekREILEKIASGE-ID 150
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 74659870 122 FVIATPGRLADHIRssgedtirgFRRVRYVVMDEADR--------LLTPGFVPDL 168
Cdd:cd17992 151 IVIGTHALIQEDVE---------FHNLGLVIIDEQHRfgveqrlkLREKGETPHV 196
|
|
| cas3_core |
TIGR01587 |
CRISPR-associated helicase Cas3; This model represents the highly conserved core region of an ... |
247-346 |
4.24e-03 |
|
CRISPR-associated helicase Cas3; This model represents the highly conserved core region of an alignment of Cas3, a protein found in association with CRISPR repeat elements in a broad range of bacteria and archaea. Cas3 appears to be a helicase, with regions found by pfam00270 (DEAD/DEAH box helicase) and pfam00271 (Helicase conserved C-terminal domain). Some but not all members have an N-terminal HD domain region (pfam01966) that is not included within this model.
Pssm-ID: 273707 [Multi-domain] Cd Length: 359 Bit Score: 38.97 E-value: 4.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 247 NEKKSAIIFVNRTQTAETLRRMLMAL--DVKTASLHSEMRQQERVNALGR-----FRAQAARVLVATDVASRGLDIPTVE 319
Cdd:TIGR01587 220 KKGGSIAIIVNTVDRAQEFYQQLKEKapEEEIILYHSRFTEKDRAKKEAEllremKKSNEKFVIVATQVIEASLDISADV 299
|
90 100
....*....|....*....|....*..
gi 74659870 320 MVINfdlPADADDYIHRVGRTARAGRK 346
Cdd:TIGR01587 300 MITE---LAPIDSLIQRLGRLHRYGRK 323
|
|
| SF2_C_RecG |
cd18811 |
C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a ... |
234-339 |
5.14e-03 |
|
C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a critical role in recombination and DNA repair. RecG helps process Holliday junction intermediates to mature products by catalyzing branch migration. It is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350198 [Multi-domain] Cd Length: 159 Bit Score: 37.71 E-value: 5.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 234 REAYLWAILTHpDNEKKSAiifVNRTQTAETLRRMLMAlDVKTASLHSEMRQQERVNALGRFRAQAARVLVATDVASRGL 313
Cdd:cd18811 27 RQAYVIYPLIE-ESEKLDL---KAAVAMYEYLKERFRP-ELNVGLLHGRLKSDEKDAVMAEFREGEVDILVSTTVIEVGV 101
|
90 100 110
....*....|....*....|....*....|....*.
gi 74659870 314 DIP--TVeMVINfdlpaDADDY----IH----RVGR 339
Cdd:cd18811 102 DVPnaTV-MVIE-----DAERFglsqLHqlrgRVGR 131
|
|
| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
47-156 |
9.91e-03 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 37.25 E-value: 9.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659870 47 TGSGKTiaFAAPMLAEWSKDPCGIFG------LVLTPTRELAIQiaeQFTALGANMNIRVALIYG--GVDMVKQSLELQK 118
Cdd:cd18034 25 TGSGKT--LIAVMLIKEMGELNRKEKnpkkraVFLVPTVPLVAQ---QAEAIRSHTDLKVGEYSGemGVDKWTKERWKEE 99
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 74659870 119 M--PHFVIATPGRLADHIRssgedtiRGF---RRVRYVVMDEA 156
Cdd:cd18034 100 LekYDVLVMTAQILLDALR-------HGFlslSDINLLIFDEC 135
|
|
| |
