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Conserved domains on  [gi|745999830|ref|YP_009114638|]
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NADH dehydrogenase subunit 6 (mitochondrion) [Propithecus edwardsi]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009569)

NADH dehydrogenase subunit 6 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 5.08e-71

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 214421  Cd Length: 175  Bit Score: 211.97  E-value: 5.08e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999830   1 MAYVVFMLSVGFVLGFMSFSSKPSPIYGGVGLIVSGAVGCGMVMNFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999830  81 TWGSSVVIWGALLLGSVMELLVMMLMVGCEGLG-GVGFISLENWITFMDKEVGVVREDSLGVTALYGKTSWFVMIAAWSL 159
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEvVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|...
gi 745999830 160 FVSVLIVIEIIRG 172
Cdd:MTH00109 162 FIGVFVIIEITRG 174
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 5.08e-71

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 211.97  E-value: 5.08e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999830   1 MAYVVFMLSVGFVLGFMSFSSKPSPIYGGVGLIVSGAVGCGMVMNFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999830  81 TWGSSVVIWGALLLGSVMELLVMMLMVGCEGLG-GVGFISLENWITFMDKEVGVVREDSLGVTALYGKTSWFVMIAAWSL 159
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEvVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|...
gi 745999830 160 FVSVLIVIEIIRG 172
Cdd:MTH00109 162 FIGVFVIIEITRG 174
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
21-169 4.76e-09

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 52.12  E-value: 4.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999830   21 SKPSPIYGGVGLIVSGAVGCGMVMNFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEYPETWGSSVVIWGALLLGSVmeL 100
Cdd:pfam00499   5 TSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGLL--L 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 745999830  101 LVMMLMVgceglggvgFISLENWITFMDKEVGVVREDSLGVtALYGKTSWFVMIAAWSLFVSVLIVIEI 169
Cdd:pfam00499  83 LALLLLV---------LLSASLTPAAAAAAPDVGNIEAIGE-LLFTDYLLPFELASVLLLVALVGAIVL 141
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 5.08e-71

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 211.97  E-value: 5.08e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999830   1 MAYVVFMLSVGFVLGFMSFSSKPSPIYGGVGLIVSGAVGCGMVMNFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999830  81 TWGSSVVIWGALLLGSVMELLVMMLMVGCEGLG-GVGFISLENWITFMDKEVGVVREDSLGVTALYGKTSWFVMIAAWSL 159
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEvVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|...
gi 745999830 160 FVSVLIVIEIIRG 172
Cdd:MTH00109 162 FIGVFVIIEITRG 174
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 1-172 6.93e-33

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 114.85  E-value: 6.93e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999830   1 MAYVVFMLSVGFVLGFMSFSSKPSPIYGGVGLIVSGAVGCGMVMNFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00138   1 MTYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999830  81 TWGSSVViwgallLGSVMELLVMMLMVGCEGLGGVGFISlenWITFMD-KEVGVVREDSLGVTALYGKTSWFVMIAAWSL 159
Cdd:MTH00138  81 SWGSWSV------LGYVVGYLVGVVLAAGLFWGGWYEGS---WVVVDElKEFSVLRGDVGGVALMYSSGGGMLVICAWVL 151

                        170
                 ....*....|...
gi 745999830 160 FVSVLIVIEIIRG 172
Cdd:MTH00138 152 LLTLFVVLELTRG 164
ND6 MTH00065
NADH dehydrogenase subunit 6; Provisional
 1-172 3.98e-32

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214415  Cd Length: 172  Bit Score: 113.02  E-value: 3.98e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999830   1 MAYVVFMLSVGFVLGFMSFSSKPSPIYGGVGLIVSGAVGCGMVMNFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00065   1 MMYLGFLGMLGLVVGLVAVASNPSPYFAALGLVLGAVCGCLVLVELGVSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999830  81 TWGSSVVIWgaLLLGSVMELLVMMLMVGCeglggvgFISLENWITFMDKEVGVVREDSLGVTALYGKTSWFVMIAAWSLF 160
Cdd:MTH00065  81 AWGSWSVLV--YVLFYLLLLIVGYILFGC-------NFSLEFLFTNYDTEFSVVGYDWGGVGLMYSSGGWFLMISGWVLL 151

                        170
                 ....*....|..
gi 745999830 161 VSVLIVIEIIRG 172
Cdd:MTH00065 152 LTLFVVLEVTRG 163
ND6 MTH00115
NADH dehydrogenase subunit 6; Provisional
 1-172 1.18e-24

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214424  Cd Length: 174  Bit Score: 93.66  E-value: 1.18e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999830   1 MAYVVFMLSVGFVLGFMSFSSKPSPIYGGVGLIVSGAVGCGMVMNFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00115   1 MMYFVFLLGVCFVLGVVGVASNPSPYYGVVSLVLASVFGCGVLVSLGGSFVSLVLFLVYLGGMLVVFAYSVSLAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999830  81 TWGSSVVIWGALLLGSVMeLLVMMLMVGCEGLGGVGFISLENWitfmdkEVGVVREDSLGVTALYGKTSWFVMIAAWSLF 160
Cdd:MTH00115  81 AWGDWGVVGYVVGFVLVV-VVVGVVVGGLWGMEGVGVVTVDSG------GLFVVRLDFSGVSLFYSSGGGGLLVCGWGLL 153

                        170
                 ....*....|..
gi 745999830 161 VSVLIVIEIIRG 172
Cdd:MTH00115 154 LTLFVVLELVRG 165
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 1-172 5.19e-16

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 71.17  E-value: 5.19e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999830   1 MAYVVFMLSVGFVLGFMSFSSKPSPIYGGVGLIVSGAVGCGMVMNFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00214   1 MLYFVFLLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999830  81 TWGSSVVIWGALLLGSVMELLVMMLMVGCEGLGGVGFISLENwitfmdkevgvvrEDSLGVTALYGKTSWFVMIAAWSLF 160
Cdd:MTH00214  81 SWGGWSVLLFFLFYLLGLGFVGFYFYGGWEMLSWMGVDEANN-------------LDLSGVSDLYSRGFFLLLLGGVVLF 147

                        170
                 ....*....|..
gi 745999830 161 VSVLIVIEIIRG 172
Cdd:MTH00214 148 LVLFVVLELVRG 159
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
21-169 4.76e-09

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 52.12  E-value: 4.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999830   21 SKPSPIYGGVGLIVSGAVGCGMVMNFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEYPETWGSSVVIWGALLLGSVmeL 100
Cdd:pfam00499   5 TSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGLL--L 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 745999830  101 LVMMLMVgceglggvgFISLENWITFMDKEVGVVREDSLGVtALYGKTSWFVMIAAWSLFVSVLIVIEI 169
Cdd:pfam00499  83 LALLLLV---------LLSASLTPAAAAAAPDVGNIEAIGE-LLFTDYLLPFELASVLLLVALVGAIVL 141
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 24-172 1.77e-08

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 51.06  E-value: 1.77e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999830  24 SPIYGGVGLIVSGAVGCGMVMNFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEYPETWGSSVVIWGALLLGSvmellvm 103
Cdd:MTH00045  22 SPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVYSSALSAERYPSVSNLGEVLVLSLLLSL------- 94

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999830 104 mlmvgceglggVGFISLENWITFMDKEVGVVREDSL-GVTALYGKTSWFVMIAAWSLFVSVLIVIEIIRG 172
Cdd:MTH00045  95 -----------WVFISFDNFLELSNNNWSLVSLSDLvGSSELYNSGGLYLLLGGFILLVALVVALVISFG 153
ND6 MTH00212
NADH dehydrogenase subunit 6; Provisional
 7-127 1.97e-03

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214460  Cd Length: 160  Bit Score: 36.91  E-value: 1.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999830   7 MLSVGFVLGFMsFSSKPSPIYGGVGLIVSGAVGCGMVMNFGGSFVGLMVFLIYLGGMLVVFGYTTAMAteeyPETWGSSV 86
Cdd:MTH00212   6 LLSLLLLLMLL-FPLSAHPLTLGVSLLLSSLLSCLIITMESNSWYGYILFLIYIGGLLVLFGYMVALS----PNEHLFFK 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 745999830  87 VIWGALLLGSVMELLVMMLMV-GCEGLGGVGFISLENWITFM 127
Cdd:MTH00212  81 KYFKGFGMILISLNLYLLLMTlGSSNFSPMLNLKLELNVSKI 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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