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Conserved domains on  [gi|745999816|ref|YP_009114625|]
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NADH dehydrogenase subunit 6 (mitochondrion) [Varecia variegata]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009569)

NADH dehydrogenase subunit 6 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 2.73e-71

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 214421  Cd Length: 175  Bit Score: 212.74  E-value: 2.73e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999816   1 MMYVMFLLSVLFVLGFMGISSKPSPIYGGVGLIVSGGVGCGIVMGFGGSFMGLMMFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999816  81 TWGSSIVIWGVLLLGVGLELFVVVWMVNHISLGILDSFGSIEDWVIFGGKEGGVVREDSLGVASLYNFTSSFMAVAGWSL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|..
gi 745999816 161 FISVLIVVEIVR 172
Cdd:MTH00109 162 FIGVFVIIEITR 173
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 2.73e-71

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 212.74  E-value: 2.73e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999816   1 MMYVMFLLSVLFVLGFMGISSKPSPIYGGVGLIVSGGVGCGIVMGFGGSFMGLMMFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999816  81 TWGSSIVIWGVLLLGVGLELFVVVWMVNHISLGILDSFGSIEDWVIFGGKEGGVVREDSLGVASLYNFTSSFMAVAGWSL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|..
gi 745999816 161 FISVLIVVEIVR 172
Cdd:MTH00109 162 FIGVFVIIEITR 173
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
17-117 3.98e-07

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 46.73  E-value: 3.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999816   17 MGISSKPSPIYGGVGLIVSGGVGCGIVMGFGGSFMGLMMFLIYLGGMLVVFGYTTAM-ATEEYPETWGSSIVIWGVLLLG 95
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLlLAEEEPEKLRSGLPLAALLLGL 80

                          90       100
                  ....*....|....*....|..
gi 745999816   96 VGLELFVVVWMVNHISLGILDS 117
Cdd:pfam00499  81 LLLALLLLVLLSASLTPAAAAA 102
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 2.73e-71

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 212.74  E-value: 2.73e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999816   1 MMYVMFLLSVLFVLGFMGISSKPSPIYGGVGLIVSGGVGCGIVMGFGGSFMGLMMFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999816  81 TWGSSIVIWGVLLLGVGLELFVVVWMVNHISLGILDSFGSIEDWVIFGGKEGGVVREDSLGVASLYNFTSSFMAVAGWSL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|..
gi 745999816 161 FISVLIVVEIVR 172
Cdd:MTH00109 162 FIGVFVIIEITR 173
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 1-172 2.59e-35

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 121.02  E-value: 2.59e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999816   1 MMYVMFLLSVLFVLGFMGISSKPSPIYGGVGLIVSGGVGCGIVMGFGGSFMGLMMFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00138   1 MTYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999816  81 TWGSSIVIWGVLLLGVGLELFVVVWMVN--HISLGILDSFgsiedwvifggKEGGVVREDSLGVASLYNFTSSFMAVAGW 158
Cdd:MTH00138  81 SWGSWSVLGYVVGYLVGVVLAAGLFWGGwyEGSWVVVDEL-----------KEFSVLRGDVGGVALMYSSGGGMLVICAW 149

                        170
                 ....*....|....
gi 745999816 159 SLFISVLIVVEIVR 172
Cdd:MTH00138 150 VLLLTLFVVLELTR 163
ND6 MTH00065
NADH dehydrogenase subunit 6; Provisional
 1-172 3.17e-31

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214415  Cd Length: 172  Bit Score: 110.71  E-value: 3.17e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999816   1 MMYVMFLLSVLFVLGFMGISSKPSPIYGGVGLIVSGGVGCGIVMGFGGSFMGLMMFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00065   1 MMYLGFLGMLGLVVGLVAVASNPSPYFAALGLVLGAVCGCLVLVELGVSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999816  81 TWGSsiviWGVLLLGVGLELFVVVWMVnhislgILDSFGSIEDWVIFGGKEGGVVREDSLGVASLYNFTSSFMAVAGWSL 160
Cdd:MTH00065  81 AWGS----WSVLVYVLFYLLLLIVGYI------LFGCNFSLEFLFTNYDTEFSVVGYDWGGVGLMYSSGGWFLMISGWVL 150

                        170
                 ....*....|..
gi 745999816 161 FISVLIVVEIVR 172
Cdd:MTH00065 151 LLTLFVVLEVTR 162
ND6 MTH00115
NADH dehydrogenase subunit 6; Provisional
 1-172 1.29e-26

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214424  Cd Length: 174  Bit Score: 99.05  E-value: 1.29e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999816   1 MMYVMFLLSVLFVLGFMGISSKPSPIYGGVGLIVSGGVGCGIVMGFGGSFMGLMMFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00115   1 MMYFVFLLGVCFVLGVVGVASNPSPYYGVVSLVLASVFGCGVLVSLGGSFVSLVLFLVYLGGMLVVFAYSVSLAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999816  81 TWGSSIVIWGVLLLGVGLELFVVVWmvnhisLGILDSFGSIEDWVIFGGkeGGVVREDSLGVASLYNFTSSFMAVAGWSL 160
Cdd:MTH00115  81 AWGDWGVVGYVVGFVLVVVVVGVVV------GGLWGMEGVGVVTVDSGG--LFVVRLDFSGVSLFYSSGGGGLLVCGWGL 152

                        170
                 ....*....|..
gi 745999816 161 FISVLIVVEIVR 172
Cdd:MTH00115 153 LLTLFVVLELVR 164
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 1-172 1.34e-15

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 70.02  E-value: 1.34e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999816   1 MMYVMFLLSVLFVLGFMGISSKPSPIYGGVGLIVSGGVGCGIVMGFGGSFMGLMMFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00214   1 MLYFVFLLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999816  81 TWGSSIVIWGvlllgvglelfvVVWMVNHISLGILDSFGSIEDWVIFGGKEGGVVreDSLGVASLYNFTSSFMAVAGWSL 160
Cdd:MTH00214  81 SWGGWSVLLF------------FLFYLLGLGFVGFYFYGGWEMLSWMGVDEANNL--DLSGVSDLYSRGFFLLLLGGVVL 146

                        170
                 ....*....|..
gi 745999816 161 FISVLIVVEIVR 172
Cdd:MTH00214 147 FLVLFVVLELVR 158
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 1-172 8.13e-08

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 49.13  E-value: 8.13e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999816   1 MMYVMFLLSVLFVLGFMGISSkpSPIYGGVGLIVSGGVGCGIVMGFGGSFMGLMMFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00045   1 MVFYLFLILMLFGSTLVFYSL--SPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVYSSALSAERYPS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999816  81 TWGSSIVIwgvlllgvGLELFVVVWMvnhislgildsFGSIEDWVIFGGKEGGVVREDSL-GVASLYNFTSSFMAVAGWS 159
Cdd:MTH00045  79 VSNLGEVL--------VLSLLLSLWV-----------FISFDNFLELSNNNWSLVSLSDLvGSSELYNSGGLYLLLGGFI 139

                        170
                 ....*....|...
gi 745999816 160 LFISVLIVVEIVR 172
Cdd:MTH00045 140 LLVALVVALVISF 152
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
17-117 3.98e-07

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 46.73  E-value: 3.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999816   17 MGISSKPSPIYGGVGLIVSGGVGCGIVMGFGGSFMGLMMFLIYLGGMLVVFGYTTAM-ATEEYPETWGSSIVIWGVLLLG 95
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLlLAEEEPEKLRSGLPLAALLLGL 80

                          90       100
                  ....*....|....*....|..
gi 745999816   96 VGLELFVVVWMVNHISLGILDS 117
Cdd:pfam00499  81 LLLALLLLVLLSASLTPAAAAA 102
ND6 MTH00212
NADH dehydrogenase subunit 6; Provisional
 2-78 2.80e-04

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214460  Cd Length: 160  Bit Score: 39.22  E-value: 2.80e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 745999816   2 MYVMFLLSVLFVLGFMGISSKpSPIYGGVGLIVSGGVGCGIVMGFGGSFMGLMMFLIYLGGMLVVFGYTTAMATEEY 78
Cdd:MTH00212   1 MLLSLLLSLLLLLMLLFPLSA-HPLTLGVSLLLSSLLSCLIITMESNSWYGYILFLIYIGGLLVLFGYMVALSPNEH 76
ND6 MTH00152
NADH dehydrogenase subunit 6; Provisional
 2-74 5.14e-03

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214437  Cd Length: 163  Bit Score: 35.63  E-value: 5.14e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 745999816   2 MYVMFLLSVLFVLGFMGISSKpSPIYGGVGLIVSGGVGCGIVMGFGGSFMGLMMFLIYLGGMLVVFGYTTAMA 74
Cdd:MTH00152   1 MSLMILLSVCFSLFLLLPLSK-QPLSLGLVLLLLSLFVCVEIGLTLSSWYGYLLFLVYVGGLLVMFAYVVSLS 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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