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Conserved domains on  [gi|745999813|ref|YP_009114622|]
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NADH dehydrogenase subunit 4L (mitochondrion) [Varecia variegata]

Protein Classification

NADH-ubiquinone oxidoreductase chain 4L( domain architecture ID 10009568)

NADH-ubiquinone oxidoreductase chain 4L is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) and is believed to belong to the minimal assembly required for catalysis; Complex I functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.51e-38

NADH dehydrogenase subunit 4L; Provisional


:

Pssm-ID: 177169  Cd Length: 98  Bit Score: 123.89  E-value: 1.51e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999813  1 MPSIFINIILAFIIALLGMLIFRSHLMSSLLCLESMMLSMFILSTLTILSLHLTTSFMMPILLLVFAACEAAVGLALLVT 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 745999813 81 VSNTYGLDYIQNLNLLQC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.51e-38

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 123.89  E-value: 1.51e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999813  1 MPSIFINIILAFIIALLGMLIFRSHLMSSLLCLESMMLSMFILSTLTILSLHLTTSFMMPILLLVFAACEAAVGLALLVT 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 745999813 81 VSNTYGLDYIQNLNLLQC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
3-98 3.34e-10

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 51.80  E-value: 3.34e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999813   3 SIFINIILAFIIALLGMLiFRSHLMSSLLCLESMMLSMFILSTLTILSLHLTTSFMMPILLLVFAACEAAVGLALLVTVS 82
Cdd:pfam00420  1 AYLLLSGLLFLIGLYGLL-LRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|....*.
gi 745999813  83 NTYGLDYIQNLNLLQC 98
Cdd:pfam00420 80 RTHGTDDVDSLNLLKG 95
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.51e-38

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 123.89  E-value: 1.51e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999813  1 MPSIFINIILAFIIALLGMLIFRSHLMSSLLCLESMMLSMFILSTLTILSLHLTTSFMMPILLLVFAACEAAVGLALLVT 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 745999813 81 VSNTYGLDYIQNLNLLQC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 11-98 1.65e-22

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177185  Cd Length: 98  Bit Score: 83.48  E-value: 1.65e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999813 11 AFIIALLGMLIFRSHLMSSLLCLESMMLSMFILSTLTILSLHLTTSFMMPILLLVFAACEAAVGLALLVTVSNTYGLDYI 90
Cdd:MTH00126 11 AFILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAAPMLLLAFSACEASAGLALLVATARTHGTDRL 90


                ....*...
gi 745999813 91 QNLNLLQC 98
Cdd:MTH00126 91 QNLNLLQC 98
ND4L MTH00125
NADH dehydrogenase subunit 4L; Provisional
 1-98 3.59e-22

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177184  Cd Length: 98  Bit Score: 82.59  E-value: 3.59e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999813  1 MPSIFINIILAFIIALLGMLIFRSHLMSSLLCLESMMLSMFILSTLTILSLHLTTSFMMPILLLVFAACEAAVGLALLVT 80
Cdd:MTH00125  1 MTPTHFSLYTAFMLSLLGLSFHRTHLMSALLCLESMMLSLFIMLSLWPITTQTPSFTPMPIILLTFSACEAGTGLALLVA 80

                        90
                ....*....|....*...
gi 745999813 81 VSNTYGLDYIQNLNLLQC 98
Cdd:MTH00125 81 TTRTHGSDHLKNLNLLQC 98
ND4L MTH00067
NADH dehydrogenase subunit 4L; Provisional
 1-98 2.78e-18

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177139  Cd Length: 98  Bit Score: 72.71  E-value: 2.78e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999813  1 MPSIFINIILAFIIALLGMLIFRSHLMSSLLCLESMMLSMFILSTLTILSLHLTTSFMMPILLLVFAACEAAVGLALLVT 80
Cdd:MTH00067  1 MSPTYFTFYSAFLLGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWSTQFESLSYFSLPMFMLTFSACEASTGLALMVA 80

                        90
                ....*....|....*...
gi 745999813 81 VSNTYGLDYIQNLNLLQC 98
Cdd:MTH00067 81 TTRTHGTDHLKNLNLLQC 98
ND4L MTH00181
NADH dehydrogenase subunit 4L; Provisional
 9-96 6.83e-13

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214450  Cd Length: 93  Bit Score: 58.80  E-value: 6.83e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999813  9 ILAFIIALLGMLIFRSHLMSSLLCLESMMLSMFILSTLTILSLHLTTSFMMPILLLVFAACEAAVGLALLVTVSNTYGLD 88
Cdd:MTH00181  6 ISAFILLLLGLSLYKTHLLSLLLCLEGMMLFLFLLLALFSLLSSSSSMLMFGLILLTFSACEAVLGLSLLVATNRTHGSD 85


                ....*...
gi 745999813 89 YIQNLNLL 96
Cdd:MTH00181 86 HLLKFNLL 93
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
3-98 3.34e-10

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 51.80  E-value: 3.34e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999813   3 SIFINIILAFIIALLGMLiFRSHLMSSLLCLESMMLSMFILSTLTILSLHLTTSFMMPILLLVFAACEAAVGLALLVTVS 82
Cdd:pfam00420  1 AYLLLSGLLFLIGLYGLL-LRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|....*.
gi 745999813  83 NTYGLDYIQNLNLLQC 98
Cdd:pfam00420 80 RTHGTDDVDSLNLLKG 95
ND4L MTH00043
NADH dehydrogenase subunit 4L; Validated
 1-97 5.99e-10

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 214410  Cd Length: 98  Bit Score: 51.46  E-value: 5.99e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999813  1 MPSIFINIILAFIIALLGMLIFRSHLMSSLLCLESMMLSMFILSTLTILSLHLTTSFMMPILLLVFAACEAAVGLALLVT 80
Cdd:MTH00043  1 MNIILIIILSSFFLGLLGILINRLHLLSILLCLELLLISLFLNISIWSLNYGNFSNLSFSLLLLTLSACEASIGLSLMVL 80

                        90
                ....*....|....*..
gi 745999813 81 VSNTYGLDYIQNLNLLQ 97
Cdd:MTH00043 81 LSRNHNSDLVASLNLLQ 97
ND4L MTH00188
NADH dehydrogenase subunit 4L; Provisional
 3-98 1.13e-08

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177237  Cd Length: 97  Bit Score: 48.05  E-value: 1.13e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999813  3 SIFINIILAFIIALLGMLIFRSHLMSSLLCLESMMLSMFILstLTILSLHLTTSFMMPILLLVFAACEAAVGLALLVTVS 82
Cdd:MTH00188  4 SMILVILLFVVLGLFTFLLNRKHLLMLLLSLEAIMLSLFWF--LLVGLSYMEKELYLSLVLLTFAACEASVGLALLVSLI 81

                        90
                ....*....|....*.
gi 745999813 83 NTYGLDYIQNLNLLQC 98
Cdd:MTH00188 82 RSHGSDYVSSLNLIKC 97
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 3-92 1.58e-06

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 42.45  E-value: 1.58e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999813  3 SIFINIILAFIIALLGMLIFRSHLMSSLLCLESMMLSMFILstLTILSLHLTTSFMMPILLLVFAACEAAVGLALLVTVS 82
Cdd:MTH00162  2 MMLLIFLFMFFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFL--LFLYLSFFNYELYFLLFFLTFSVCEGALGLSILVSMI 79

                        90
                ....*....|
gi 745999813 83 NTYGLDYIQN 92
Cdd:MTH00162 80 RSHGNDYFSS 89
ND4L MTH00013
NADH dehydrogenase subunit 4L; Validated
 1-98 4.10e-06

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 133655  Cd Length: 97  Bit Score: 41.28  E-value: 4.10e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999813  1 MPSIFINIILAFIIALLGMLIFRSHLMSSLLCLESMMLSMFILsTLTILSLHLTTSFMMPILLLVFAACEAAVGLALLVT 80
Cdd:MTH00013  1 MMSPLFILSISPFISMFNLSLQRKHLLMSLLSLEAMILSLALF-IPLSLMFANQVNGMLAIVLLTFGACEASLGLSLLVL 79

                        90
                ....*....|....*...
gi 745999813 81 VSNTYGLDYIQNLNLLQC 98
Cdd:MTH00013 80 MTRSYGNDMLKSLTSNKC 97
ND4L MTH00149
NADH dehydrogenase subunit 4L; Provisional
 1-98 2.87e-05

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214434  Cd Length: 97  Bit Score: 39.06  E-value: 2.87e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999813  1 MPSIFINIILAFIIALLGMLIFRSHLMSSLLCLESMMLSMFILSTLTilSLHLTTSFMMPILLLVFAACEAAVGLALLVT 80
Cdd:MTH00149  2 MFMLLLLSLFGFLMGVFALLFQYKHLLSILLSLEALMLSLLVMMFSS--SGLISFSSYLFLIILTFGACEASLGLSLLVS 79

                        90
                ....*....|....*...
gi 745999813 81 VSNTYGLDYIQNLNLLQC 98
Cdd:MTH00149 80 LIRLHGNDYVSSLSSLKF 97
ND4L MTH00180
NADH dehydrogenase subunit 4L; Provisional
 9-97 2.47e-03

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177231  Cd Length: 99  Bit Score: 34.24  E-value: 2.47e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999813  9 ILAFIIALLGMLIFRSHLMSSLLCLESMMLSMFILSTLTILSLHLTTSFMMPILLLVFAACEAAVGLALLVTVSNTYGLD 88
Cdd:MTH00180 10 IILFILGVLGIVLNRSNLIIMLMSIELMLLAISLLFLINSVAIDNLIGQIFTIMILTVAAAESAIGLAILVAYYRIRGTI 89


                ....*....
gi 745999813 89 YIQNLNLLQ 97
Cdd:MTH00180 90 AVKSLNLLR 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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