NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|745851104|gb|AJD76132|]
View 

polyprotein, partial [Hepacivirus hominis]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
HCV_NS1 super family cl03263
Hepatitis C virus non-structural protein E2/NS1; The hypervariable region of the E2/NS1 region ...
 60-160 8.41e-61

Hepatitis C virus non-structural protein E2/NS1; The hypervariable region of the E2/NS1 region of hepatitis C virus varies greatly between viral isolates. E2 is thought to encode a structurally unconstrained envelope protein.


The actual alignment was detected with superfamily member pfam01560:

Pssm-ID: 110557  Cd Length: 344  Bit Score: 191.22  E-value: 8.41e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745851104   60 HVTGGMAARNTFTLTSLFHMGPQQKIQLVNTNGSWHINRTALNCNDSLNTGFLAALFYTHRFNSSGCPERMASCLTIDQF 139
Cdd:pfam01560   1 HVTGGSAARTTRGLVSLFSPGAKQNIQLINTNGSWHINRTALNCNDSLQTGFLASLFYTHRFNSSGCPERLASCRSIDDF 80

                          90       100
                  ....*....|....*....|.
gi 745851104  140 DQGWGPVTYAEPNSSDQRPYC 160
Cdd:pfam01560  81 RQGWGPITYEETNPEDQRPYC 101
HCV_env super family cl03255
Hepatitis C virus envelope glycoprotein E1;
1-56 4.77e-28

Hepatitis C virus envelope glycoprotein E1;


The actual alignment was detected with superfamily member pfam01539:

Pssm-ID: 110536  Cd Length: 190  Bit Score: 102.65  E-value: 4.77e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 745851104    1 SPTTALVVSQLLRIPQAIVDMVAGAHWGVLAGLAYYSMVGNWAKVLIVMLLFAGVD 56
Cdd:pfam01539 135 SPTATMILAYALRVPEAVLDIIAGAHWGVLFGLAYFSMQGAWAKVLVILLLFAGVD 190
 
Name Accession Description Interval E-value
HCV_NS1 pfam01560
Hepatitis C virus non-structural protein E2/NS1; The hypervariable region of the E2/NS1 region ...
 60-160 8.41e-61

Hepatitis C virus non-structural protein E2/NS1; The hypervariable region of the E2/NS1 region of hepatitis C virus varies greatly between viral isolates. E2 is thought to encode a structurally unconstrained envelope protein.


Pssm-ID: 110557  Cd Length: 344  Bit Score: 191.22  E-value: 8.41e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745851104   60 HVTGGMAARNTFTLTSLFHMGPQQKIQLVNTNGSWHINRTALNCNDSLNTGFLAALFYTHRFNSSGCPERMASCLTIDQF 139
Cdd:pfam01560   1 HVTGGSAARTTRGLVSLFSPGAKQNIQLINTNGSWHINRTALNCNDSLQTGFLASLFYTHRFNSSGCPERLASCRSIDDF 80

                          90       100
                  ....*....|....*....|.
gi 745851104  140 DQGWGPVTYAEPNSSDQRPYC 160
Cdd:pfam01560  81 RQGWGPITYEETNPEDQRPYC 101
HCV_env pfam01539
Hepatitis C virus envelope glycoprotein E1;
1-56 4.77e-28

Hepatitis C virus envelope glycoprotein E1;


Pssm-ID: 110536  Cd Length: 190  Bit Score: 102.65  E-value: 4.77e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 745851104    1 SPTTALVVSQLLRIPQAIVDMVAGAHWGVLAGLAYYSMVGNWAKVLIVMLLFAGVD 56
Cdd:pfam01539 135 SPTATMILAYALRVPEAVLDIIAGAHWGVLFGLAYFSMQGAWAKVLVILLLFAGVD 190
 
Name Accession Description Interval E-value
HCV_NS1 pfam01560
Hepatitis C virus non-structural protein E2/NS1; The hypervariable region of the E2/NS1 region ...
 60-160 8.41e-61

Hepatitis C virus non-structural protein E2/NS1; The hypervariable region of the E2/NS1 region of hepatitis C virus varies greatly between viral isolates. E2 is thought to encode a structurally unconstrained envelope protein.


Pssm-ID: 110557  Cd Length: 344  Bit Score: 191.22  E-value: 8.41e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745851104   60 HVTGGMAARNTFTLTSLFHMGPQQKIQLVNTNGSWHINRTALNCNDSLNTGFLAALFYTHRFNSSGCPERMASCLTIDQF 139
Cdd:pfam01560   1 HVTGGSAARTTRGLVSLFSPGAKQNIQLINTNGSWHINRTALNCNDSLQTGFLASLFYTHRFNSSGCPERLASCRSIDDF 80

                          90       100
                  ....*....|....*....|.
gi 745851104  140 DQGWGPVTYAEPNSSDQRPYC 160
Cdd:pfam01560  81 RQGWGPITYEETNPEDQRPYC 101
HCV_env pfam01539
Hepatitis C virus envelope glycoprotein E1;
1-56 4.77e-28

Hepatitis C virus envelope glycoprotein E1;


Pssm-ID: 110536  Cd Length: 190  Bit Score: 102.65  E-value: 4.77e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 745851104    1 SPTTALVVSQLLRIPQAIVDMVAGAHWGVLAGLAYYSMVGNWAKVLIVMLLFAGVD 56
Cdd:pfam01539 135 SPTATMILAYALRVPEAVLDIIAGAHWGVLFGLAYFSMQGAWAKVLVILLLFAGVD 190
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH