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Conserved domains on  [gi|743896193|ref|XP_011041371|]
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PREDICTED: cysteine proteinase inhibitor 6-like [Populus euphratica]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CY super family cl09238
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 51-124 1.59e-21

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


The actual alignment was detected with superfamily member pfam16845:

Pssm-ID: 447698  Cd Length: 83  Bit Score: 84.78  E-value: 1.59e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 743896193   51 IDSLARFAVQEHNKKENAILEFVRVLKAKEQVVAGKLYHLTLEAIDA-GNNKMYEVKVWVKPWMNFKQLQEFKHV 124
Cdd:pfam16845   9 VVEIAKFAVSEHNKQSKANLVFVKVVKGETQVVSGTNYRLVIAAKDGgGATKNYEAVVWEKPWEHFRSLTSFKAL 83
CY super family cl09238
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 142-186 8.97e-04

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


The actual alignment was detected with superfamily member smart00043:

Pssm-ID: 447698  Cd Length: 107  Bit Score: 37.79  E-value: 8.97e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 743896193   142 GWQSVPTNDLEVQDAANHAVKSIQKRSNSLspYELVEILLAKAKV 186
Cdd:smart00043   5 GPSDVPPNDPEVQEAADFAVAEYNKKSNDK--YELRVIKVVSAKS 47
 
Name Accession Description Interval E-value
SQAPI pfam16845
Aspartic acid proteinase inhibitor; SQAPI, aspartic acid inhibitor first isolated from squash, ...
 51-124 1.59e-21

Aspartic acid proteinase inhibitor; SQAPI, aspartic acid inhibitor first isolated from squash, inhibits a wide range of aspartic proteinases. This particular family of PAAPIs (proteinaceous aspartic acid inhibitors) seems to have evolved quite recently from an ancestral cystatin. Structurally it consists of a four-stranded anti-parallel beta-sheet gripping an alpha-helix in much the same manner that a hand grips a tennis racket. The unstructured N-terminus and the loop connecting beta-strands 1 and 2 are important for pepsin inhibition, but the loop connecting strands 3 and 4 is not.


Pssm-ID: 407092  Cd Length: 83  Bit Score: 84.78  E-value: 1.59e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 743896193   51 IDSLARFAVQEHNKKENAILEFVRVLKAKEQVVAGKLYHLTLEAIDA-GNNKMYEVKVWVKPWMNFKQLQEFKHV 124
Cdd:pfam16845   9 VVEIAKFAVSEHNKQSKANLVFVKVVKGETQVVSGTNYRLVIAAKDGgGATKNYEAVVWEKPWEHFRSLTSFKAL 83
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 36-124 3.56e-19

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 79.39  E-value: 3.56e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743896193    36 LGGVHDCkgSQNSAEIDSLARFAVQEHNKKENAILEF--VRVLKAKEQVVAGKLYHLTLEAID----------------A 97
Cdd:smart00043   3 LGGPSDV--PPNDPEVQEAADFAVAEYNKKSNDKYELrvIKVVSAKSQVVAGTNYYLKVEVGEtnckklsvdlencpflD 80

                           90       100
                   ....*....|....*....|....*..
gi 743896193    98 GNNKMYEVKVWVKPWMNFKQLQEFKHV 124
Cdd:smart00043  81 QGEKFCTAKVWEKPWENKIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 47-123 1.96e-17

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 74.82  E-value: 1.96e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743896193  47 NSAEIDSLARFAVQEHNKKENA-ILEFVRVLKAKEQVVAGKLYHLTLEAIDA-------------------GNNKMYEVK 106
Cdd:cd00042    9 NDPEVQELADFAVAEYNKKSNDkYLEFFKVLSAKSQVVAGTNYYITVEAGDTnckkssvpldcpdcklleeGKKKFCTAK 88

                         90
                 ....*....|....*..
gi 743896193 107 VWVKPWMNFKQLQEFKH 123
Cdd:cd00042   89 VWEKPWENFKELLSFKC 105
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 142-186 8.97e-04

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 37.79  E-value: 8.97e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 743896193   142 GWQSVPTNDLEVQDAANHAVKSIQKRSNSLspYELVEILLAKAKV 186
Cdd:smart00043   5 GPSDVPPNDPEVQEAADFAVAEYNKKSNDK--YELRVIKVVSAKS 47
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 142-187 1.08e-03

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 37.45  E-value: 1.08e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 743896193 142 GWQSVPTNDLEVQDAANHAVKSIQKRSNSlSPYELVEILLAKAKVI 187
Cdd:cd00042    2 GPSDIPANDPEVQELADFAVAEYNKKSND-KYLEFFKVLSAKSQVV 46
 
Name Accession Description Interval E-value
SQAPI pfam16845
Aspartic acid proteinase inhibitor; SQAPI, aspartic acid inhibitor first isolated from squash, ...
 51-124 1.59e-21

Aspartic acid proteinase inhibitor; SQAPI, aspartic acid inhibitor first isolated from squash, inhibits a wide range of aspartic proteinases. This particular family of PAAPIs (proteinaceous aspartic acid inhibitors) seems to have evolved quite recently from an ancestral cystatin. Structurally it consists of a four-stranded anti-parallel beta-sheet gripping an alpha-helix in much the same manner that a hand grips a tennis racket. The unstructured N-terminus and the loop connecting beta-strands 1 and 2 are important for pepsin inhibition, but the loop connecting strands 3 and 4 is not.


Pssm-ID: 407092  Cd Length: 83  Bit Score: 84.78  E-value: 1.59e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 743896193   51 IDSLARFAVQEHNKKENAILEFVRVLKAKEQVVAGKLYHLTLEAIDA-GNNKMYEVKVWVKPWMNFKQLQEFKHV 124
Cdd:pfam16845   9 VVEIAKFAVSEHNKQSKANLVFVKVVKGETQVVSGTNYRLVIAAKDGgGATKNYEAVVWEKPWEHFRSLTSFKAL 83
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 36-124 3.56e-19

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 79.39  E-value: 3.56e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743896193    36 LGGVHDCkgSQNSAEIDSLARFAVQEHNKKENAILEF--VRVLKAKEQVVAGKLYHLTLEAID----------------A 97
Cdd:smart00043   3 LGGPSDV--PPNDPEVQEAADFAVAEYNKKSNDKYELrvIKVVSAKSQVVAGTNYYLKVEVGEtnckklsvdlencpflD 80

                           90       100
                   ....*....|....*....|....*..
gi 743896193    98 GNNKMYEVKVWVKPWMNFKQLQEFKHV 124
Cdd:smart00043  81 QGEKFCTAKVWEKPWENKIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 47-123 1.96e-17

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 74.82  E-value: 1.96e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743896193  47 NSAEIDSLARFAVQEHNKKENA-ILEFVRVLKAKEQVVAGKLYHLTLEAIDA-------------------GNNKMYEVK 106
Cdd:cd00042    9 NDPEVQELADFAVAEYNKKSNDkYLEFFKVLSAKSQVVAGTNYYITVEAGDTnckkssvpldcpdcklleeGKKKFCTAK 88

                         90
                 ....*....|....*..
gi 743896193 107 VWVKPWMNFKQLQEFKH 123
Cdd:cd00042   89 VWEKPWENFKELLSFKC 105
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 37-122 6.09e-14

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 65.05  E-value: 6.09e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743896193   37 GGVHDCKGsqNSAEIDSLARFAVQEHNKKE-NAILEFVRVLKAKEQVVAGKLYHLTLEAIDA---GNNKMYEVKVWV-KP 111
Cdd:pfam00031   1 GGLSPIPD--NSPELQEALDFALAEYNAKTdNYYFELVEVKRAKSQVVAGTNYFIKVEVGETdcsKSKKLLEDCPLLdEK 78

                          90
                  ....*....|.
gi 743896193  112 WMNFKQLQEFK 122
Cdd:pfam00031  79 WLGLCSAQVYK 89
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 142-186 8.97e-04

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 37.79  E-value: 8.97e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 743896193   142 GWQSVPTNDLEVQDAANHAVKSIQKRSNSLspYELVEILLAKAKV 186
Cdd:smart00043   5 GPSDVPPNDPEVQEAADFAVAEYNKKSNDK--YELRVIKVVSAKS 47
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 142-187 1.08e-03

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 37.45  E-value: 1.08e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 743896193 142 GWQSVPTNDLEVQDAANHAVKSIQKRSNSlSPYELVEILLAKAKVI 187
Cdd:cd00042    2 GPSDIPANDPEVQELADFAVAEYNKKSND-KYLEFFKVLSAKSQVV 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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