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Conserved domains on  [gi|742799298|ref|NP_001290371|]
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protein HEXIM2 isoform 1 [Homo sapiens]

Protein Classification

HEXIM domain-containing protein( domain architecture ID 10633900)

HEXIM domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HEXIM pfam15313
Hexamethylene bis-acetamide-inducible protein; HEXIM is a transcriptional regulator that ...
 102-227 4.69e-60

Hexamethylene bis-acetamide-inducible protein; HEXIM is a transcriptional regulator that functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA it sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. HEXIM may also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.


:

Pssm-ID: 464638  Cd Length: 136  Bit Score: 187.28  E-value: 4.69e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799298  102 WRPYLELSWAEKQQRDERQSQRASRVREEMFAKGQPVAPYNTTQFLMNDRDPEEPNLDVPHGISHPGSSGESEAGDS--- 178
Cdd:pfam15313   1 WKPYSKLSWEEKKQLDERETQRASRVRAEMFAKGQPVAPYNTTQFLMDDHDKEEPDLNTELGPRRSRSRGSSFDSSSedd 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 742799298  179 -------DGRGRAHGEFQRKDFSETYERFHTESLQGRSKQELVRDYLELEKRLSQA 227
Cdd:pfam15313  81 yfesepdEDLGSDGGEFLEKDFSETYERYHAERLQNMSKQELIQEYLELEKKLSQL 136
YabA super family cl47350
Regulator of replication initiation timing YabA [Replication, recombination and repair];
216-271 2.42e-04

Regulator of replication initiation timing YabA [Replication, recombination and repair];


The actual alignment was detected with superfamily member COG4467:

Pssm-ID: 443564 [Multi-domain]  Cd Length: 107  Bit Score: 39.47  E-value: 2.42e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 742799298 216 DYLELEKRLSQAEEetrRLQQLQactgqqscRQVEELAAEVQRLRTENQRLRQENQ 271
Cdd:COG4467    2 DKKELFDRLSELEE---QLGELL--------KELGELKDEVAELLEENARLRIENE 46
 
Name Accession Description Interval E-value
HEXIM pfam15313
Hexamethylene bis-acetamide-inducible protein; HEXIM is a transcriptional regulator that ...
 102-227 4.69e-60

Hexamethylene bis-acetamide-inducible protein; HEXIM is a transcriptional regulator that functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA it sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. HEXIM may also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.


Pssm-ID: 464638  Cd Length: 136  Bit Score: 187.28  E-value: 4.69e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799298  102 WRPYLELSWAEKQQRDERQSQRASRVREEMFAKGQPVAPYNTTQFLMNDRDPEEPNLDVPHGISHPGSSGESEAGDS--- 178
Cdd:pfam15313   1 WKPYSKLSWEEKKQLDERETQRASRVRAEMFAKGQPVAPYNTTQFLMDDHDKEEPDLNTELGPRRSRSRGSSFDSSSedd 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 742799298  179 -------DGRGRAHGEFQRKDFSETYERFHTESLQGRSKQELVRDYLELEKRLSQA 227
Cdd:pfam15313  81 yfesepdEDLGSDGGEFLEKDFSETYERYHAERLQNMSKQELIQEYLELEKKLSQL 136
YabA COG4467
Regulator of replication initiation timing YabA [Replication, recombination and repair];
216-271 2.42e-04

Regulator of replication initiation timing YabA [Replication, recombination and repair];


Pssm-ID: 443564 [Multi-domain]  Cd Length: 107  Bit Score: 39.47  E-value: 2.42e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 742799298 216 DYLELEKRLSQAEEetrRLQQLQactgqqscRQVEELAAEVQRLRTENQRLRQENQ 271
Cdd:COG4467    2 DKKELFDRLSELEE---QLGELL--------KELGELKDEVAELLEENARLRIENE 46
 
Name Accession Description Interval E-value
HEXIM pfam15313
Hexamethylene bis-acetamide-inducible protein; HEXIM is a transcriptional regulator that ...
 102-227 4.69e-60

Hexamethylene bis-acetamide-inducible protein; HEXIM is a transcriptional regulator that functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA it sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. HEXIM may also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.


Pssm-ID: 464638  Cd Length: 136  Bit Score: 187.28  E-value: 4.69e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799298  102 WRPYLELSWAEKQQRDERQSQRASRVREEMFAKGQPVAPYNTTQFLMNDRDPEEPNLDVPHGISHPGSSGESEAGDS--- 178
Cdd:pfam15313   1 WKPYSKLSWEEKKQLDERETQRASRVRAEMFAKGQPVAPYNTTQFLMDDHDKEEPDLNTELGPRRSRSRGSSFDSSSedd 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 742799298  179 -------DGRGRAHGEFQRKDFSETYERFHTESLQGRSKQELVRDYLELEKRLSQA 227
Cdd:pfam15313  81 yfesepdEDLGSDGGEFLEKDFSETYERYHAERLQNMSKQELIQEYLELEKKLSQL 136
YabA COG4467
Regulator of replication initiation timing YabA [Replication, recombination and repair];
216-271 2.42e-04

Regulator of replication initiation timing YabA [Replication, recombination and repair];


Pssm-ID: 443564 [Multi-domain]  Cd Length: 107  Bit Score: 39.47  E-value: 2.42e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 742799298 216 DYLELEKRLSQAEEetrRLQQLQactgqqscRQVEELAAEVQRLRTENQRLRQENQ 271
Cdd:COG4467    2 DKKELFDRLSELEE---QLGELL--------KELGELKDEVAELLEENARLRIENE 46
FtsB COG2919
Cell division protein FtsB [Cell cycle control, cell division, chromosome partitioning];
236-276 1.67e-03

Cell division protein FtsB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442163 [Multi-domain]  Cd Length: 96  Bit Score: 37.17  E-value: 1.67e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 742799298 236 QLQACTGQQSCRQVEELAAEVQRLRTENQRLRQENQMWNRE 276
Cdd:COG2919   18 QYHLWFGDGGLLAYRELRQEIAELEAENAKLKARNAELEAE 58
ZapB COG3074
Cell division protein ZapB, interacts with FtsZ [Cell cycle control, cell division, chromosome ...
 219-276 2.07e-03

Cell division protein ZapB, interacts with FtsZ [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442308 [Multi-domain]  Cd Length: 79  Bit Score: 36.49  E-value: 2.07e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 742799298 219 ELEKRLSQAEEETRRLQ----QLQAcTGQQSCRQVEELAAEVQRLRTENQRLRQENQMWNRE 276
Cdd:COG3074    8 ELEAKVQQAVDTIELLQmeveELKE-KNEELEQENEELQSENEELQSENEQLKTENAEWQER 68
COG4026 COG4026
Uncharacterized conserved protein, contains TOPRIM domain, potential nuclease [General ...
 204-283 6.75e-03

Uncharacterized conserved protein, contains TOPRIM domain, potential nuclease [General function prediction only];


Pssm-ID: 443204 [Multi-domain]  Cd Length: 287  Bit Score: 37.40  E-value: 6.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799298 204 SLQG-RSKQELVRDYLELEKRLSQAEEETRRLQQlqactgqqscrQVEELAAEVQRLRTENQRLRQENQMWNREGCRCDE 282
Cdd:COG4026  123 SLQNiPEYNELREELLELKEKIDEIAKEKEKLTK-----------ENEELESELEELREEYKKLREENSILEEEFDNIKS 191


                 .
gi 742799298 283 E 283
Cdd:COG4026  192 E 192
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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