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Conserved domains on  [gi|74271890|ref|NP_001028204|]
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fas apoptotic inhibitory molecule 1 isoform c [Homo sapiens]

Protein Classification

FAIM1 domain-containing protein( domain architecture ID 10536459)

FAIM1 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FAIM1 pfam06905
Fas apoptotic inhibitory molecule (FAIM1); This family consists of several fas apoptotic ...
 4-176 4.69e-114

Fas apoptotic inhibitory molecule (FAIM1); This family consists of several fas apoptotic inhibitory molecule (FAIM1) proteins. FAIM expression is upregulated in B cells by anti-Ig treatment that induces Fas-resistance, and overexpression of FAIM diminishes sensitivity to Fas-mediated apoptosis of B and non-B cell lines. FAIM1 is highly evolutionarily conserved and is widely expressed in murine tissues, suggesting that FAIM plays an important role in cellular physiology.


:

Pssm-ID: 462035  Cd Length: 172  Bit Score: 321.05  E-value: 4.69e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74271890     4 LVAVWDVALSDGVHKIEFEHGTTSGKRVVYVDGKEEIRKEWMFKLVGKETFYVGaaKTKATINIDAISGFAYEYTLEING 83
Cdd:pfam06905   1 LVAVWDVPLSDGVHKIEFEHGTTTGKRVIRVDGKEVLRRDWMFKLVGKETFKIG--GTKCTIRIEAVSGFAYEYTLEVNG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74271890    84 KSLKKYMEDRSKTTNTWVLHMDGENFRIVLEKDAMDVWCNGKKLETAGEFVDDGTETHFSIGNHDCYIKAVSSGKRKEGI 163
Cdd:pfam06905  79 KSLKKFKENQSKTLKTWEPTIDGKEYRIVLEKDTMDVWVNGQKVETAGEFVDDGTETHFTLGDTPCYIKAVSSGKKKEGI 158

                         170
                  ....*....|...
gi 74271890   164 IHTLIVDNREIPE 176
Cdd:pfam06905 159 IHSLYVNNTEIPE 171
 
Name Accession Description Interval E-value
FAIM1 pfam06905
Fas apoptotic inhibitory molecule (FAIM1); This family consists of several fas apoptotic ...
 4-176 4.69e-114

Fas apoptotic inhibitory molecule (FAIM1); This family consists of several fas apoptotic inhibitory molecule (FAIM1) proteins. FAIM expression is upregulated in B cells by anti-Ig treatment that induces Fas-resistance, and overexpression of FAIM diminishes sensitivity to Fas-mediated apoptosis of B and non-B cell lines. FAIM1 is highly evolutionarily conserved and is widely expressed in murine tissues, suggesting that FAIM plays an important role in cellular physiology.


Pssm-ID: 462035  Cd Length: 172  Bit Score: 321.05  E-value: 4.69e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74271890     4 LVAVWDVALSDGVHKIEFEHGTTSGKRVVYVDGKEEIRKEWMFKLVGKETFYVGaaKTKATINIDAISGFAYEYTLEING 83
Cdd:pfam06905   1 LVAVWDVPLSDGVHKIEFEHGTTTGKRVIRVDGKEVLRRDWMFKLVGKETFKIG--GTKCTIRIEAVSGFAYEYTLEVNG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74271890    84 KSLKKYMEDRSKTTNTWVLHMDGENFRIVLEKDAMDVWCNGKKLETAGEFVDDGTETHFSIGNHDCYIKAVSSGKRKEGI 163
Cdd:pfam06905  79 KSLKKFKENQSKTLKTWEPTIDGKEYRIVLEKDTMDVWVNGQKVETAGEFVDDGTETHFTLGDTPCYIKAVSSGKKKEGI 158

                         170
                  ....*....|...
gi 74271890   164 IHTLIVDNREIPE 176
Cdd:pfam06905 159 IHSLYVNNTEIPE 171
 
Name Accession Description Interval E-value
FAIM1 pfam06905
Fas apoptotic inhibitory molecule (FAIM1); This family consists of several fas apoptotic ...
 4-176 4.69e-114

Fas apoptotic inhibitory molecule (FAIM1); This family consists of several fas apoptotic inhibitory molecule (FAIM1) proteins. FAIM expression is upregulated in B cells by anti-Ig treatment that induces Fas-resistance, and overexpression of FAIM diminishes sensitivity to Fas-mediated apoptosis of B and non-B cell lines. FAIM1 is highly evolutionarily conserved and is widely expressed in murine tissues, suggesting that FAIM plays an important role in cellular physiology.


Pssm-ID: 462035  Cd Length: 172  Bit Score: 321.05  E-value: 4.69e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74271890     4 LVAVWDVALSDGVHKIEFEHGTTSGKRVVYVDGKEEIRKEWMFKLVGKETFYVGaaKTKATINIDAISGFAYEYTLEING 83
Cdd:pfam06905   1 LVAVWDVPLSDGVHKIEFEHGTTTGKRVIRVDGKEVLRRDWMFKLVGKETFKIG--GTKCTIRIEAVSGFAYEYTLEVNG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74271890    84 KSLKKYMEDRSKTTNTWVLHMDGENFRIVLEKDAMDVWCNGKKLETAGEFVDDGTETHFSIGNHDCYIKAVSSGKRKEGI 163
Cdd:pfam06905  79 KSLKKFKENQSKTLKTWEPTIDGKEYRIVLEKDTMDVWVNGQKVETAGEFVDDGTETHFTLGDTPCYIKAVSSGKKKEGI 158

                         170
                  ....*....|...
gi 74271890   164 IHTLIVDNREIPE 176
Cdd:pfam06905 159 IHSLYVNNTEIPE 171
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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