F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 74220552  13 LESLPTDPLLLILSFVDYRDLINCCYVSRRLSQLSTHDPLWRRHCKKYW 61
Cdd:cd22084   1 LDDLPSDPLLNILSFLDYRDLISCSQVCRRLNQLCSHDPLWKRLCKKYW 49

CO2+/MG2+ efflux protein ApaG; Reviewed

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74220552  279 ATTGDITVSVSTSFLPELSSVHPPHYFFTYRIRIE-MSRDALpekacQLDSRYWRITNAKGDVEEVQGPGVVGEFPIISP 357
Cdd:PRK05461   4 AVTYGIEVSVQPRYLEEQSDPEEGRYVFAYTITIEnLGRVPV-----QLLSRHWLITDANGRVQEVRGEGVVGEQPVLAP 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 74220552  358 GRIYEYTSCTTFSTTSGYMEGYYTFHflyfkD---KVFNVAIPRFHMACP 404
Cdd:PRK05461  79 GESFEYTSGAVLETPSGTMQGHYQMV-----DedgERFEVPIPPFRLAVP 123

F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 74220552  13 LESLPTDPLLLILSFVDYRDLINCCYVSRRLSQLSTHDPLWRRHCKKYW 61
Cdd:cd22084   1 LDDLPSDPLLNILSFLDYRDLISCSQVCRRLNQLCSHDPLWKRLCKKYW 49

SMI1 / KNR4 family (SUKH-1); Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation. Genome contextual information showed that SMI1 are primary immunity proteins in bacterial toxin systems.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74220552   121 GAREEDLDAVEAQIGCKLPDDYRCSYRIHNGQKLVVPG--LLGSMALSNHYRSEDLLDVDtaagGFQQRQGLKYCLpLTF 198
Cdd:pfam09346   1 PATEEEIQEFEKELGVKLPEDYREFLLKTNGGGGLFEGldLLPLEEIEEEYEDLLAEDSL----YFIREWGLPEGL-IPF 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 74220552   199 CiHTGLSQYIAVEAAEGRNKNEVFYQCPDqmarnpaAIDMFIIGATFTDWF 249
Cdd:pfam09346  76 A-DDGGGDYLCLDLRDGGEEGQVYFWDED-------DDELKLVADSFEEFL 118

SMI1 / KNR4 family; Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74220552    121 GAREEDLDAVEAQIGCKLPDDYRCSYRIHNGQKLVV---PGLLGSMALSNHYRSEDLLDVDTAAGGFQQRQGLKYCLPLT 197
Cdd:smart00860   1 PATEEEIAELEKKLGIKLPEDYKEFLLLYNGGELGGsaeLPLGGLSLLDLLELEAAIEDQEEIDSDIEEEEYALPGWLIF 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 74220552    198 FCIHTGLSQYIAVEAAEGRNKNEVFYQCPDQMARNPaaidmFIIGATFTDWF 249
Cdd:smart00860  81 IADGGGGGILIDLDDGPGGEGGEVGVILFGDDDDEK-----YVVADSFEEFL 127

CO2+/MG2+ efflux protein ApaG; Reviewed

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74220552  279 ATTGDITVSVSTSFLPELSSVHPPHYFFTYRIRIE-MSRDALpekacQLDSRYWRITNAKGDVEEVQGPGVVGEFPIISP 357
Cdd:PRK05461   4 AVTYGIEVSVQPRYLEEQSDPEEGRYVFAYTITIEnLGRVPV-----QLLSRHWLITDANGRVQEVRGEGVVGEQPVLAP 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 74220552  358 GRIYEYTSCTTFSTTSGYMEGYYTFHflyfkD---KVFNVAIPRFHMACP 404
Cdd:PRK05461  79 GESFEYTSGAVLETPSGTMQGHYQMV-----DedgERFEVPIPPFRLAVP 123

F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 74220552  13 LESLPTDPLLLILSFVDYRDLINCCYVSRRLSQLSTHDPLWRRHCKKYW 61
Cdd:cd22084   1 LDDLPSDPLLNILSFLDYRDLISCSQVCRRLNQLCSHDPLWKRLCKKYW 49

SMI1 / KNR4 family (SUKH-1); Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation. Genome contextual information showed that SMI1 are primary immunity proteins in bacterial toxin systems.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74220552   121 GAREEDLDAVEAQIGCKLPDDYRCSYRIHNGQKLVVPG--LLGSMALSNHYRSEDLLDVDtaagGFQQRQGLKYCLpLTF 198
Cdd:pfam09346   1 PATEEEIQEFEKELGVKLPEDYREFLLKTNGGGGLFEGldLLPLEEIEEEYEDLLAEDSL----YFIREWGLPEGL-IPF 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 74220552   199 CiHTGLSQYIAVEAAEGRNKNEVFYQCPDqmarnpaAIDMFIIGATFTDWF 249
Cdd:pfam09346  76 A-DDGGGDYLCLDLRDGGEEGQVYFWDED-------DDELKLVADSFEEFL 118

SMI1 / KNR4 family; Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74220552    121 GAREEDLDAVEAQIGCKLPDDYRCSYRIHNGQKLVV---PGLLGSMALSNHYRSEDLLDVDTAAGGFQQRQGLKYCLPLT 197
Cdd:smart00860   1 PATEEEIAELEKKLGIKLPEDYKEFLLLYNGGELGGsaeLPLGGLSLLDLLELEAAIEDQEEIDSDIEEEEYALPGWLIF 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 74220552    198 FCIHTGLSQYIAVEAAEGRNKNEVFYQCPDQMARNPaaidmFIIGATFTDWF 249
Cdd:smart00860  81 IADGGGGGILIDLDDGPGGEGGEVGVILFGDDDDEK-----YVVADSFEEFL 127

F-box domain found in F-box/WD repeat-containing protein 4 (FBXW4) and similar proteins; FBXW4, also called dactylin, or F-box and WD-40 domain-containing protein 4, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is likely to be involved in key signaling pathways crucial for normal limb development. It may participate in Wnt signaling and act as a novel tumor suppressor that regulates important cellular processes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 74220552  12 TLESLPTDPLLLILSFVDYRDLINCCYVSRRLSQLSTHDPLWRRHCK 58
Cdd:cd20090   1 PLLDLPDDLLFLIFSYLDPASLGRLSQVCRRLYRLISRDAVWRRIAR 47

F-box domain found in F-box only protein 15 (FBXO15) and similar proteins; FBXO15, also called FBX15, has a novel dual molecular function by controlling transcriptional repression and being part of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligases, which is essential for stress response, gliotoxin production and virulence in the opportunistic human pathogen Aspergillus fumigatus. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 74220552  13 LESLPTDPLLLILSFVDYRDLINCCYVSRRLSQLSTHDPLWRRHCK 58
Cdd:cd22093   1 IERLPSEILLKILSYLDASSLLCISCVNKLFYQLANDNALWRKLYS 46

F-box domain found in F-box only protein 4 (FBXO4) and similar proteins; FBXO4, also called FBX4, is a specific substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that catalyzes the ubiquitination and subsequent degradation of cyclin D1 and Trx1. It recognizes TERF1 and promotes its ubiquitination together with UBE2D1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 74220552  12 TLESLPTDPLLLILSFVDYRDLINCCYVSRRLSQLSTHDPLWRRHC 57
Cdd:cd22085   2 LLNHLPIDLQLYILSFLSPHDLCQLGLTSHYWHTLVRDPLLWRYFL 47

F-box domain found in F-box/WD repeat-containing protein 12 (FBXW12) and similar proteins; FBXW12, also called F-box and WD-40 domain-containing protein 12, or F-box only protein 35 (FBXO35), is the substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It functions as an epithelial growth suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 74220552  15 SLPTDPLLLILSFVDYRDLINCCYVSRRLSQLSTHDPLWRRHC 57
Cdd:cd22137   2 QLPDLPMLRIFSFLDAFSLLQAAQVNKQWNKVADSDYLWRNLC 44

F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar proteins; SpPof1, also called F-box/WD repeat-containing protein pof1, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is required for the inactivation of zip1 via ubiquitination. This subfamily also includes Saccharomyces cerevisiae methionine-requiring protein 30 (ScMET30, also called E3 ubiquitin ligase complex SCF(Met30) subunit MET30), Aspergillus niger sulfur controller B (AnSCONB, also called sulfur metabolite repression control protein B) and Neurospora crassa sulfur controller 2 (NcSCON2, also called sulfur metabolite repression control protein 2). ScMET30 acts as a transcriptional inhibitor that negatively regulates the expression of sulfur amino acid biosynthesis genes. It controls cell cycle function (being required for the G1/S transition and M-phase but not the S-phase), sulfur metabolism, and methionine biosynthesis as part of the E3 ubiquitin ligase complex SCF(Met30). AnSCONB and NcSCON2 are components of the SCF (sconB/scon-2) E3 ubiquitin ligase complexes involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 74220552  13 LESLPTDPLLLILSFVDYRDLINCCYVSRRLSQLSTHDPLWRRHC 57
Cdd:cd22147   2 LSALPVELSLKILSYLDAKSLCRAAQVSKKWRNLADDDELWKRMC 46

F-box domain found in F-box only proteins FBXO6, FBXO44 and similar proteins; This subfamily includes FBXO6 and FBXO44. FBXO6, also called FBX6, F-box protein that recognizes sugar chains 2 (FBS2), or F-box/G-domain protein 2 (FBG2), is a substrate-recognition component of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. It is involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins, by recognizing and binding sugar chains on unfolded glycoproteins that are retro-translocated into the cytosol and promoting their ubiquitination and subsequent degradation. FBXO6 can recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. It also recognizes sulfated glycans. FBXO6 is involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. FBXO44, also called FBXO6A, FBX44, or F-box/G-domain protein 3 (FBG3), is a substrate-recognition component of an SCF-type E3 ubiquitin ligase complex. It interacts with SKP1 and CUL1. FBXO44 mediates BRCA1 ubiquitination and degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74220552  11 LTLESLPTDPLLLILSFVDYRDLI-NC---CYVSRRLSQLSThdpLWRRHCKKYWLISEEEKaGKSQCWR 76
Cdd:cd22168   2 LTISDLPEDVLLEILSLVPARDLIlSCrlvCSRWRDLVDLPT---LWKRKCQREGFILKDWD-GPPKDWK 67

F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called FBX41, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a novel central nervous system (CNS)-specific F-box protein that localizes to the centrosome and the cytoplasm of neurons and promotes neuronal migration. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 74220552  13 LESLPT-DPLLLILSFVDYRDLINCCYVSRRLSQLSTHDPLWRRHC 57
Cdd:cd22109   2 LESLRRrDALFCVFSYLDTKSLLRCAEVCREWRDVSRHPALWQRVC 47

F-box domain found in F-box only protein 36 (FBXO36) and similar proteins; FBXO36, also called FBX36, likely functions as the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 74220552  13 LESLPTDPLLLILSFVDYRDLINCCYVSRRLSQLSTHDPLWRR 55
Cdd:cd22106   1 LVRLPDKLLLYIISYLDLEDIARLSQTSKRFKKLCNSDELWEK 43

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 22 (AtSKIP22) and similar proteins; AtSKIP22, also called F-box protein SKIP22, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with SKP1A/ASK1 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 74220552  13 LESLPTDPLLLILSFVDYRDLINCCYVSRRLSQLSTHDPLWRRHC 57
Cdd:cd22165   2 LMRLPTELKLKILELLPGVDLARMACVCSELRFLASNDDLWKQKF 46

F-box domain found in F-box only protein 1 (FBXO1) and similar proteins; FBXO1, also called FBX1, or cyclin-F, is a substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 74220552  12 TLESLPTDPLLLILSFVDYRDLINCCYVSRRLSQL-STHDPLWRR 55
Cdd:cd22082   1 TLWSLPEEVLLHILKGLPIKDLLNMRAVHSRFKDLiDSNPSLWAN 45

F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called FBX48, is one of the paralogs of the F-box only protein 7 (FBXO7), which is the causative gene for PARK15 (also known as Parkinsonian-pyramidal disease, PPD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 74220552  13 LESLPTDPLLLILSFVDYRDLINCCYVSRRLSQL-STHDPLWRRHC 57
Cdd:cd22113   1 IELLPPEMSLRIFSQLDVQSLCRASQTCKTWNDLiENSDYLWRPHC 46