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Conserved domains on  [gi|74180854|dbj|BAE25631|]
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unnamed protein product [Mus musculus]

Protein Classification

uracil-xanthine permease family protein( domain architecture ID 10789278)

uracil-xanthine permease family protein similar to xanthine permease and uracil permease, which mediate the transport of xanthine and uracil, respectively

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
UraA COG2233
Xanthine/uracil permease [Nucleotide transport and metabolism]; Xanthine/uracil permease is ...
37-529 2.99e-86

Xanthine/uracil permease [Nucleotide transport and metabolism]; Xanthine/uracil permease is part of the Pathway/BioSystem: Pyrimidine degradation


:

Pssm-ID: 441834  Cd Length: 439  Bit Score: 275.47  E-value: 2.99e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854  37 DMLYKIEDVPPWYLCILLGFQHYLTCFSGTIAVPFLLAEALcvGRDQHMVSQLIGTIFTCVGITTLIQTT-VGIRLPLFQ 115
Cdd:COG2233   8 GLVYGVDERPPLGQTLLLGLQHVLAMFGATVLVPLIVGGAL--GLSAAQTALLISAALFVSGIGTLLQLLgTGGRLPIVL 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854 116 ASAFAFLVPaksILAlerwkcpseeeIYGNWSMPLntshiwhprireVQGAIMVSSMVEVVIGLMGlpGALLSYIGPLTV 195
Cdd:COG2233  86 GSSFAFIAP---IIA-----------IGAAYGLAA------------ALGGIIVAGLVYILLGLLI--KRIRRLFPPVVT 137
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854 196 TPTVSLIGLSVFQAAGDRAG-----------SHWGISACSILLIVLFSQYLRnltfllpvyrwgkgltlfrvQIFKMFPI 264
Cdd:COG2233 138 GTVVMLIGLSLAPVAINMAAggpgapdfgspQNLLLALVTLAVILLLSVFGK--------------------GFLRRISI 197
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854 265 VLAIMTVWLLCYVLTLTDvlpadptvygFQARTDArgdimaisPWIRIPYPCQWGLPTVTVAAVLGMFSATLAGIIESIG 344
Cdd:COG2233 198 LIGIVVGYIVALLLGMVD----------FSPVAEA--------PWFALPTPFPFGLPTFDLGAILTMLPVALVTIAETIG 259
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854 345 DYYACARLAGAPPPPvHAINRGIFTEGICCIIAGLLGTGnGSTSSSPNIGVLGITKVGSRRVVQYGAGIMLILGAIGKFT 424
Cdd:COG2233 260 DILAVGEITGRDITD-PRLGRGLLGDGLATMLAGLFGGF-PNTTYSENIGVIALTGVYSRYVVAVAAVILILLGLFPKLG 337
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854 425 ALFASLPDPILGGMFCTLFGMITAVGLSNLQFVDMNSSRNLFVLGFSMFFGL---TLPNYLDSNPGAINTgipevdqilt 501
Cdd:COG2233 338 ALIATIPSPVLGGATIVLFGMIAASGIRILVNVDFSNPRNLLIVAVSLGLGLgvtGVPGALATLPATLGP---------- 407
                       490       500
                ....*....|....*....|....*...
gi 74180854 502 vLLTTEMFVGGCLAFILDNTVPGSPEER 529
Cdd:COG2233 408 -LFLSGIALGALVAILLNLLLPGKKEEE 434
 
Name Accession Description Interval E-value
UraA COG2233
Xanthine/uracil permease [Nucleotide transport and metabolism]; Xanthine/uracil permease is ...
37-529 2.99e-86

Xanthine/uracil permease [Nucleotide transport and metabolism]; Xanthine/uracil permease is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 441834  Cd Length: 439  Bit Score: 275.47  E-value: 2.99e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854  37 DMLYKIEDVPPWYLCILLGFQHYLTCFSGTIAVPFLLAEALcvGRDQHMVSQLIGTIFTCVGITTLIQTT-VGIRLPLFQ 115
Cdd:COG2233   8 GLVYGVDERPPLGQTLLLGLQHVLAMFGATVLVPLIVGGAL--GLSAAQTALLISAALFVSGIGTLLQLLgTGGRLPIVL 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854 116 ASAFAFLVPaksILAlerwkcpseeeIYGNWSMPLntshiwhprireVQGAIMVSSMVEVVIGLMGlpGALLSYIGPLTV 195
Cdd:COG2233  86 GSSFAFIAP---IIA-----------IGAAYGLAA------------ALGGIIVAGLVYILLGLLI--KRIRRLFPPVVT 137
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854 196 TPTVSLIGLSVFQAAGDRAG-----------SHWGISACSILLIVLFSQYLRnltfllpvyrwgkgltlfrvQIFKMFPI 264
Cdd:COG2233 138 GTVVMLIGLSLAPVAINMAAggpgapdfgspQNLLLALVTLAVILLLSVFGK--------------------GFLRRISI 197
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854 265 VLAIMTVWLLCYVLTLTDvlpadptvygFQARTDArgdimaisPWIRIPYPCQWGLPTVTVAAVLGMFSATLAGIIESIG 344
Cdd:COG2233 198 LIGIVVGYIVALLLGMVD----------FSPVAEA--------PWFALPTPFPFGLPTFDLGAILTMLPVALVTIAETIG 259
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854 345 DYYACARLAGAPPPPvHAINRGIFTEGICCIIAGLLGTGnGSTSSSPNIGVLGITKVGSRRVVQYGAGIMLILGAIGKFT 424
Cdd:COG2233 260 DILAVGEITGRDITD-PRLGRGLLGDGLATMLAGLFGGF-PNTTYSENIGVIALTGVYSRYVVAVAAVILILLGLFPKLG 337
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854 425 ALFASLPDPILGGMFCTLFGMITAVGLSNLQFVDMNSSRNLFVLGFSMFFGL---TLPNYLDSNPGAINTgipevdqilt 501
Cdd:COG2233 338 ALIATIPSPVLGGATIVLFGMIAASGIRILVNVDFSNPRNLLIVAVSLGLGLgvtGVPGALATLPATLGP---------- 407
                       490       500
                ....*....|....*....|....*...
gi 74180854 502 vLLTTEMFVGGCLAFILDNTVPGSPEER 529
Cdd:COG2233 408 -LFLSGIALGALVAILLNLLLPGKKEEE 434
Xan_ur_permease pfam00860
Permease family; This family includes permeases for diverse substrates such as xanthine, ...
52-479 5.52e-76

Permease family; This family includes permeases for diverse substrates such as xanthine, uracil and vitamin C. However many members of this family are functionally uncharacterized and may transport other substrates. Members of this family have ten predicted transmembrane helices.


Pssm-ID: 395690 [Multi-domain]  Cd Length: 389  Bit Score: 246.82  E-value: 5.52e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854    52 ILLGFQHYLTCFSGTIAVPFLLAEALCVGRDQhmVSQLIGTIFTCVGITTLIQTT-VGIRLPLFQASAFAFlVPAKSILA 130
Cdd:pfam00860   4 LLLGLQHLLAMFAATIVVPLLVGDALGLGAED--LAQLISATFLASGIGTLLQTLiFGIRLPIYLGSSFAF-VTALMIAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854   131 lerwkcpseeeiygnwsmplnTSHIWHPRIREVQGAIMVSSMVEVVIGLMGLPGALLSYIGPLTVTPTVSLIGLSVFQAA 210
Cdd:pfam00860  81 ---------------------GLADWGIALAGLFGAVLVAGVLFTLISFTGLRGRLARLFPPVVTGPVVLLIGLSLAPIA 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854   211 GDRAGSHWGISACSILLivlfsqYLRNLTFLLPVYRWGKGLTLFRVQIFKMFPIVLAIMTVWLLCYVLTLTDVLPadptv 290
Cdd:pfam00860 140 VKGAGGGWAIADGLTVG------LLDLLGLAVVVLAVILLLSVFLKGFFRQGPILIGIIAGWLLALFMGIVNFSP----- 208
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854   291 ygfqartdargdIMAISPWIRIPYPCQWGLPTVTVAAVLGMFSATLAGIIESIGDYYACARLAGAPPPPVHAINRGIFTE 370
Cdd:pfam00860 209 ------------EVMDAPWFQLPHPFPFGTPLFNPGLILTMLAVALVAIVESTGDIRAVAKVSGRDLKPKPDLRRGLLAD 276
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854   371 GICCIIAGLLGTgNGSTSSSPNIGVLGITKVGSRRVVQYGAGIMLILGAIGKFTALFASLPDPILGGMFCTLFGMITAVG 450
Cdd:pfam00860 277 GLATLLSGLFGA-FPTTTYAENIGVVALTKVYSRRVGVTAGVILILLGLIPKFAALFSSIPSPVLGGVMLVMFGMIAGSG 355
                         410       420
                  ....*....|....*....|....*....
gi 74180854   451 LSNLQFVDMNSSRNLFVLGFSMFFGLTLP 479
Cdd:pfam00860 356 VSNLITVDLDSARNLLIIAVSLVLGLGIS 384
pbuX TIGR03173
xanthine permease; All the seed members of this model are observed adjacent to genes for ...
55-491 7.13e-50

xanthine permease; All the seed members of this model are observed adjacent to genes for either xanthine phosphoribosyltransferase (for the conversion of xanthine to guanine, GenProp0696) or genes for the conversion of xanthine to urate and its concomitant catabolism (GenProp0640, GenProp0688, GenProp0686 and GenProp0687). A number of sequences scoring higher than trusted to this model are found in different genomic contexts, and the possibility exist that these transport related compounds in addition to or instead of xanthine itself. The outgroup to this family are sequences which are characterized as uracil permeases or are adjacent to established uracil phosphoribosyltransferases.


Pssm-ID: 274468  Cd Length: 406  Bit Score: 178.10  E-value: 7.13e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854    55 GFQHYLTCFSGTIAVPFLLAEALCVGRDQhmVSQLIGTIFTCVGITTLIQTT----VGIRLPLFQASAFAFLVPAKSILA 130
Cdd:TIGR03173   1 GLQHVLAMYAGAVAVPLIVGGALGLSAEQ--TAYLISADLFACGIATLIQTLgigpFGIRLPVVQGVSFAAVGPMIAIGA 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854   131 lerwkcpseeeIYGnwsmplntshiwhprIREVQGAIMVSSMVEVVIGlmGLPGALLSYIGPLtVTPTV-SLIGLSVFQA 209
Cdd:TIGR03173  79 -----------GDG---------------LGAIFGAVIVAGLFVILLA--PFFSKLVRFFPPV-VTGTViTLIGLSLMPV 129
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854   210 AGDRAG-----------SHWGISACSILLIVLFsqylrnltfllpvYRWGKGLtlfrvqiFKMFPIVLAIMTVWLLCYVL 278
Cdd:TIGR03173 130 AINWAAggagapdfgspQNLGLALLTLVIILLL-------------NRFGKGF-------LRSIAVLIGLVVGTIVAAAL 189
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854   279 TLTDvlpadptvygFQARTDArgdimaisPWIRIPYPCQWGLPTVTVAAVLGMFSATLAGIIESIGDYYACARLAGAPPP 358
Cdd:TIGR03173 190 GMVD----------FSGVAEA--------PWFALPTPFHFGAPTFDLVAILTMIIVYLVSMVETTGDFLALGEITGRKIT 251
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854   359 PvHAINRGIFTEGICCIIAGLLGTgNGSTSSSPNIGVLGITKVGSRRVVQYGAGIMLILGAIGKFTALFASLPDPILGGM 438
Cdd:TIGR03173 252 E-KDLAGGLRADGLGSALGGLFNT-FPYTSFSQNVGLVQLTGVKSRYVVAAAGVILVLLGLFPKLAALVASIPQPVLGGA 329
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 74180854   439 FCTLFGMITAVGLSNLQFVDMNSSRNLFVLGFSMFFGL---TLPNYLDSNPGAINT 491
Cdd:TIGR03173 330 GLVMFGMVAASGIRILSKVDFDRRRNLLIVAVSLGLGLgptVVPEFFSQLPAWAQT 385
PRK10720 PRK10720
uracil transporter; Provisional
40-471 2.44e-19

uracil transporter; Provisional


Pssm-ID: 236744  Cd Length: 428  Bit Score: 90.86  E-value: 2.44e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854   40 YKIEDVPPWYLCILLGFQHYLTCFSGTIAVPFLLaealcvGRDQhmvsqliGTIFTCVGITTLIQTTVGI-RLPLFQASA 118
Cdd:PRK10720   5 IGVSERPPLLQTIPLSLQHLFAMFGATVLVPILF------HINP-------ATVLLFNGIGTLLYLFICKgKIPAYLGSS 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854  119 FAFLVPAKSILALErwkcpseeeiygnwsmplntshiwhprIREVQGAImvssmveVVIGLMGLPGALLSYIG------- 191
Cdd:PRK10720  72 FAFISPVLLLLPLG---------------------------YEVALGGF-------IMCGVLFCLVALIVKKAgtgwldv 117
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854  192 ---PLTVTPTVSLIGLSVFQAAGDRAGSHWGISACSILLIVLFSQYLRNLTFLlpvyrwgkGLTLFRvQIFKMFPIVLAI 268
Cdd:PRK10720 118 lfpPAAMGAIVAVIGLELAGVAAGMAGLLPAEGQTPDSKTIIISMVTLAVTVL--------GSVLFR-GFLAIIPILIGV 188
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854  269 MTVWLLCYVLTLTDVLPadptvygfqartdargdiMAISPWIRIPypcQWGLPTVTVAAVLGMFSATLAGIIESIGDYYA 348
Cdd:PRK10720 189 LVGYALSFAMGMVDTTP------------------IIEAHWFALP---TFYTPRFEWFAILTILPAALVVIAEHVGHLVV 247
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854  349 CARLAGAPPPPVHAINRGIFTEGICCIIAGLLGtGNGSTSSSPNIGVLGITKVGSRRVVQYGAGIMLILGAIGKFTALFA 428
Cdd:PRK10720 248 TANIVKKDLLRDPGLHRSMFANGLSTVISGFFG-STPNTTYGENIGVMAITRVYSTWVIGGAAIIAILLSCVGKLAAAIQ 326
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 74180854  429 SLPDPILGGMFCTLFGMITAVGLSNL--QFVDMNSSRNL------FVLGFS 471
Cdd:PRK10720 327 AIPLPVMGGVSLLLYGVIGASGIRVLieSKVDYNKAQNLiltsviLIIGVS 377
NCS2_1 NF037981
purine/pyrimidine permease; Proteins of this family usually have 14 transmembrane domains. ...
52-475 8.00e-04

purine/pyrimidine permease; Proteins of this family usually have 14 transmembrane domains. They belong to the NSC2 superfamily transporters. They are specific purine and/or pyrimidine permeases.


Pssm-ID: 468300  Cd Length: 419  Bit Score: 42.27  E-value: 8.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854   52 ILLGFQHYLTCFSGTIAVPFLLAEALcvGRDQHMVSQLIGTIFTCVGITTLIQTTVGIRLPLFQAsafaflvPAK---SI 128
Cdd:NF037981   4 FLGGLQWMAFMIAASIAAPIAIADLF--HLNPAETAGLVQRTIFVLGIAGLLQALFGHRLPINEG-------PAGlwwGV 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854  129 LAlerwkcpseeeIYGNWSMPLNTSHIwhPRIREVQGAIMVSSMVEVVIGLMGLpgallsyIGPLTV--TPTVSLIGLS- 205
Cdd:NF037981  75 FT-----------IYAGLVGTLYSTNI--ETLQALQGAMLVSGVFFFLLSVTGL-------IDKLAVlfTPVVTFIYLLl 134
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854  206 -VFQAAGDRAGSHWGISACSI---LLIVLFSQYLRNLTFLLpvyrwgkglTLFRVQIFKMFPIVLAIMTVWLLCYVLTLT 281
Cdd:NF037981 135 lVLQLSGSFIKGMMGIGYEGNevdPLVFLLSLVVIILTFYF---------SRHKIKWIRQYSILLSLAGGWLLFALFGKA 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854  282 DVLPADPtvygfqartdargdimaiSPWIRIPYPCQWGLPTVTVAAVLGMFSATL---AGIIESIGDYYACARLAGAPPP 358
Cdd:NF037981 206 PAIAHTG------------------GSIISLPELFVFGPPVFDSGLIVTSFFITLlliANMLASIRVMEEVLKKFGKIEV 267
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854  359 PVHAINRGiFTEGICCIIAGLLGTgNGSTSSSPNIGVLGITKVGSRRVVQYGAGIMLILGAIGKFTALFASLPDPIlgGM 438
Cdd:NF037981 268 SERYRQAG-FASGINQLLGGLFSA-IGSVPISGAAGFVATTGIPSLKPFIIGSLLVVIISLFPPLMNIFASLPAPV--GY 343
                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 74180854  439 FCTLFGMITAVGLSNLQF-VDMNSSRNLFVLGFSMFFG 475
Cdd:NF037981 344 AVTFVVFSKMVGLAFGELdKEENKERARFVIGIALLAG 381
 
Name Accession Description Interval E-value
UraA COG2233
Xanthine/uracil permease [Nucleotide transport and metabolism]; Xanthine/uracil permease is ...
37-529 2.99e-86

Xanthine/uracil permease [Nucleotide transport and metabolism]; Xanthine/uracil permease is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 441834  Cd Length: 439  Bit Score: 275.47  E-value: 2.99e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854  37 DMLYKIEDVPPWYLCILLGFQHYLTCFSGTIAVPFLLAEALcvGRDQHMVSQLIGTIFTCVGITTLIQTT-VGIRLPLFQ 115
Cdd:COG2233   8 GLVYGVDERPPLGQTLLLGLQHVLAMFGATVLVPLIVGGAL--GLSAAQTALLISAALFVSGIGTLLQLLgTGGRLPIVL 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854 116 ASAFAFLVPaksILAlerwkcpseeeIYGNWSMPLntshiwhprireVQGAIMVSSMVEVVIGLMGlpGALLSYIGPLTV 195
Cdd:COG2233  86 GSSFAFIAP---IIA-----------IGAAYGLAA------------ALGGIIVAGLVYILLGLLI--KRIRRLFPPVVT 137
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854 196 TPTVSLIGLSVFQAAGDRAG-----------SHWGISACSILLIVLFSQYLRnltfllpvyrwgkgltlfrvQIFKMFPI 264
Cdd:COG2233 138 GTVVMLIGLSLAPVAINMAAggpgapdfgspQNLLLALVTLAVILLLSVFGK--------------------GFLRRISI 197
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854 265 VLAIMTVWLLCYVLTLTDvlpadptvygFQARTDArgdimaisPWIRIPYPCQWGLPTVTVAAVLGMFSATLAGIIESIG 344
Cdd:COG2233 198 LIGIVVGYIVALLLGMVD----------FSPVAEA--------PWFALPTPFPFGLPTFDLGAILTMLPVALVTIAETIG 259
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854 345 DYYACARLAGAPPPPvHAINRGIFTEGICCIIAGLLGTGnGSTSSSPNIGVLGITKVGSRRVVQYGAGIMLILGAIGKFT 424
Cdd:COG2233 260 DILAVGEITGRDITD-PRLGRGLLGDGLATMLAGLFGGF-PNTTYSENIGVIALTGVYSRYVVAVAAVILILLGLFPKLG 337
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854 425 ALFASLPDPILGGMFCTLFGMITAVGLSNLQFVDMNSSRNLFVLGFSMFFGL---TLPNYLDSNPGAINTgipevdqilt 501
Cdd:COG2233 338 ALIATIPSPVLGGATIVLFGMIAASGIRILVNVDFSNPRNLLIVAVSLGLGLgvtGVPGALATLPATLGP---------- 407
                       490       500
                ....*....|....*....|....*...
gi 74180854 502 vLLTTEMFVGGCLAFILDNTVPGSPEER 529
Cdd:COG2233 408 -LFLSGIALGALVAILLNLLLPGKKEEE 434
Xan_ur_permease pfam00860
Permease family; This family includes permeases for diverse substrates such as xanthine, ...
52-479 5.52e-76

Permease family; This family includes permeases for diverse substrates such as xanthine, uracil and vitamin C. However many members of this family are functionally uncharacterized and may transport other substrates. Members of this family have ten predicted transmembrane helices.


Pssm-ID: 395690 [Multi-domain]  Cd Length: 389  Bit Score: 246.82  E-value: 5.52e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854    52 ILLGFQHYLTCFSGTIAVPFLLAEALCVGRDQhmVSQLIGTIFTCVGITTLIQTT-VGIRLPLFQASAFAFlVPAKSILA 130
Cdd:pfam00860   4 LLLGLQHLLAMFAATIVVPLLVGDALGLGAED--LAQLISATFLASGIGTLLQTLiFGIRLPIYLGSSFAF-VTALMIAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854   131 lerwkcpseeeiygnwsmplnTSHIWHPRIREVQGAIMVSSMVEVVIGLMGLPGALLSYIGPLTVTPTVSLIGLSVFQAA 210
Cdd:pfam00860  81 ---------------------GLADWGIALAGLFGAVLVAGVLFTLISFTGLRGRLARLFPPVVTGPVVLLIGLSLAPIA 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854   211 GDRAGSHWGISACSILLivlfsqYLRNLTFLLPVYRWGKGLTLFRVQIFKMFPIVLAIMTVWLLCYVLTLTDVLPadptv 290
Cdd:pfam00860 140 VKGAGGGWAIADGLTVG------LLDLLGLAVVVLAVILLLSVFLKGFFRQGPILIGIIAGWLLALFMGIVNFSP----- 208
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854   291 ygfqartdargdIMAISPWIRIPYPCQWGLPTVTVAAVLGMFSATLAGIIESIGDYYACARLAGAPPPPVHAINRGIFTE 370
Cdd:pfam00860 209 ------------EVMDAPWFQLPHPFPFGTPLFNPGLILTMLAVALVAIVESTGDIRAVAKVSGRDLKPKPDLRRGLLAD 276
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854   371 GICCIIAGLLGTgNGSTSSSPNIGVLGITKVGSRRVVQYGAGIMLILGAIGKFTALFASLPDPILGGMFCTLFGMITAVG 450
Cdd:pfam00860 277 GLATLLSGLFGA-FPTTTYAENIGVVALTKVYSRRVGVTAGVILILLGLIPKFAALFSSIPSPVLGGVMLVMFGMIAGSG 355
                         410       420
                  ....*....|....*....|....*....
gi 74180854   451 LSNLQFVDMNSSRNLFVLGFSMFFGLTLP 479
Cdd:pfam00860 356 VSNLITVDLDSARNLLIIAVSLVLGLGIS 384
pbuX TIGR03173
xanthine permease; All the seed members of this model are observed adjacent to genes for ...
55-491 7.13e-50

xanthine permease; All the seed members of this model are observed adjacent to genes for either xanthine phosphoribosyltransferase (for the conversion of xanthine to guanine, GenProp0696) or genes for the conversion of xanthine to urate and its concomitant catabolism (GenProp0640, GenProp0688, GenProp0686 and GenProp0687). A number of sequences scoring higher than trusted to this model are found in different genomic contexts, and the possibility exist that these transport related compounds in addition to or instead of xanthine itself. The outgroup to this family are sequences which are characterized as uracil permeases or are adjacent to established uracil phosphoribosyltransferases.


Pssm-ID: 274468  Cd Length: 406  Bit Score: 178.10  E-value: 7.13e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854    55 GFQHYLTCFSGTIAVPFLLAEALCVGRDQhmVSQLIGTIFTCVGITTLIQTT----VGIRLPLFQASAFAFLVPAKSILA 130
Cdd:TIGR03173   1 GLQHVLAMYAGAVAVPLIVGGALGLSAEQ--TAYLISADLFACGIATLIQTLgigpFGIRLPVVQGVSFAAVGPMIAIGA 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854   131 lerwkcpseeeIYGnwsmplntshiwhprIREVQGAIMVSSMVEVVIGlmGLPGALLSYIGPLtVTPTV-SLIGLSVFQA 209
Cdd:TIGR03173  79 -----------GDG---------------LGAIFGAVIVAGLFVILLA--PFFSKLVRFFPPV-VTGTViTLIGLSLMPV 129
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854   210 AGDRAG-----------SHWGISACSILLIVLFsqylrnltfllpvYRWGKGLtlfrvqiFKMFPIVLAIMTVWLLCYVL 278
Cdd:TIGR03173 130 AINWAAggagapdfgspQNLGLALLTLVIILLL-------------NRFGKGF-------LRSIAVLIGLVVGTIVAAAL 189
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854   279 TLTDvlpadptvygFQARTDArgdimaisPWIRIPYPCQWGLPTVTVAAVLGMFSATLAGIIESIGDYYACARLAGAPPP 358
Cdd:TIGR03173 190 GMVD----------FSGVAEA--------PWFALPTPFHFGAPTFDLVAILTMIIVYLVSMVETTGDFLALGEITGRKIT 251
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854   359 PvHAINRGIFTEGICCIIAGLLGTgNGSTSSSPNIGVLGITKVGSRRVVQYGAGIMLILGAIGKFTALFASLPDPILGGM 438
Cdd:TIGR03173 252 E-KDLAGGLRADGLGSALGGLFNT-FPYTSFSQNVGLVQLTGVKSRYVVAAAGVILVLLGLFPKLAALVASIPQPVLGGA 329
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 74180854   439 FCTLFGMITAVGLSNLQFVDMNSSRNLFVLGFSMFFGL---TLPNYLDSNPGAINT 491
Cdd:TIGR03173 330 GLVMFGMVAASGIRILSKVDFDRRRNLLIVAVSLGLGLgptVVPEFFSQLPAWAQT 385
ncs2 TIGR00801
uracil-xanthine permease; The Nucleobase:Cation Symporter-2 (NCS2) Family (TC 2.A.40) Most of ...
46-518 4.06e-42

uracil-xanthine permease; The Nucleobase:Cation Symporter-2 (NCS2) Family (TC 2.A.40) Most of the functionally characterized members of the NCS2 family are transporters specific for nucleobases including both purines and pyrimidines. However, two closely related rat members of the family, SVCT1 and SVCT2, localized to different tissues of the body, cotransport L-ascorbate and Na+ with a high degree of specificity and high affinity for the vitamin. The NCS2 family appears to be distantly related to the NCS1 family (TC #2.A.39). [Transport and binding proteins, Nucleosides, purines and pyrimidines]


Pssm-ID: 273276  Cd Length: 412  Bit Score: 156.69  E-value: 4.06e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854    46 PPWYLCILLGFQHYLTCFSGTIAVPFLLAEALCVGRDQHMvsqLIGTIFTCVGITTLIQ---TTVGIRLPLFQASAFAFL 122
Cdd:TIGR00801   2 PPLLQTIFLSLQHLLAMFAGAVLVPLLVGIALGLSAELQY---LVSIALLTSGVGTLLQlfrTGGFIGLPSVLGSSFAFI 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854   123 VPakSILALERWKCPseeEIYGnwsmplntshiwhprirevqGAIMVSSMVEVVIGLMGLPGALLSYIGPLTVT-PTVSL 201
Cdd:TIGR00801  79 AP--MIMIGSGLGVP---AIYG--------------------ALIATGLLYFLVSFIIKKLGPLLDRLFPPVVTgPVVML 133
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854   202 IGLSVFQAAGDRAGSHWGISACSILLIVLFSqyLRNLTFLLPVYRWGKGLtlfrvqiFKMFPIVLAIMTVWLLCYVLTLT 281
Cdd:TIGR00801 134 IGLSLIPVAIDNAAGGEGAATYGSLENLGLA--FVVLALIILLNRFFKGF-------LKSISILIGILVGYILALAMGLV 204
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854   282 DvlpadptvygFQARTDArgdimaisPWIRIPYPCQWGlPTVTVAAVLGMFSATLAGIIESIGDYYACARLAGAPPPPVH 361
Cdd:TIGR00801 205 D----------FSPVIEA--------PWFSLPTPFTFP-PSFEWPAILTMLPVAIVTLVESIGDITATADVSGRDLSGDP 265
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854   362 AINRGIFTEGICCIIAGLLGtGNGSTSSSPNIGVLGITKVGSRRVVqYGAGIMLI-LGAIGKFTALFASLPDPILGGMFC 440
Cdd:TIGR00801 266 RLHRGVLADGLATLIGGLFG-SFPNTTFAQNIGVIALTRVASRWVI-VGAAVILIaLGLVPKIAALITSIPSPVLGGAML 343
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 74180854   441 TLFGMITAVGLSNLQFVDMNSSRNLFVLGFSMFFGLTLpnyldsnpgainTGIPEVDQILTVLLTTEMFVGGCLAFIL 518
Cdd:TIGR00801 344 VMFGMVAASGIRILSRSKLDFRRNLLIIAASVGLGLGV------------TGVPDIFGNLPLLLLSGIALAGIVAILL 409
PRK10720 PRK10720
uracil transporter; Provisional
40-471 2.44e-19

uracil transporter; Provisional


Pssm-ID: 236744  Cd Length: 428  Bit Score: 90.86  E-value: 2.44e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854   40 YKIEDVPPWYLCILLGFQHYLTCFSGTIAVPFLLaealcvGRDQhmvsqliGTIFTCVGITTLIQTTVGI-RLPLFQASA 118
Cdd:PRK10720   5 IGVSERPPLLQTIPLSLQHLFAMFGATVLVPILF------HINP-------ATVLLFNGIGTLLYLFICKgKIPAYLGSS 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854  119 FAFLVPAKSILALErwkcpseeeiygnwsmplntshiwhprIREVQGAImvssmveVVIGLMGLPGALLSYIG------- 191
Cdd:PRK10720  72 FAFISPVLLLLPLG---------------------------YEVALGGF-------IMCGVLFCLVALIVKKAgtgwldv 117
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854  192 ---PLTVTPTVSLIGLSVFQAAGDRAGSHWGISACSILLIVLFSQYLRNLTFLlpvyrwgkGLTLFRvQIFKMFPIVLAI 268
Cdd:PRK10720 118 lfpPAAMGAIVAVIGLELAGVAAGMAGLLPAEGQTPDSKTIIISMVTLAVTVL--------GSVLFR-GFLAIIPILIGV 188
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854  269 MTVWLLCYVLTLTDVLPadptvygfqartdargdiMAISPWIRIPypcQWGLPTVTVAAVLGMFSATLAGIIESIGDYYA 348
Cdd:PRK10720 189 LVGYALSFAMGMVDTTP------------------IIEAHWFALP---TFYTPRFEWFAILTILPAALVVIAEHVGHLVV 247
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854  349 CARLAGAPPPPVHAINRGIFTEGICCIIAGLLGtGNGSTSSSPNIGVLGITKVGSRRVVQYGAGIMLILGAIGKFTALFA 428
Cdd:PRK10720 248 TANIVKKDLLRDPGLHRSMFANGLSTVISGFFG-STPNTTYGENIGVMAITRVYSTWVIGGAAIIAILLSCVGKLAAAIQ 326
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 74180854  429 SLPDPILGGMFCTLFGMITAVGLSNL--QFVDMNSSRNL------FVLGFS 471
Cdd:PRK10720 327 AIPLPVMGGVSLLLYGVIGASGIRVLieSKVDYNKAQNLiltsviLIIGVS 377
PRK11412 PRK11412
uracil/xanthine transporter;
52-523 1.66e-05

uracil/xanthine transporter;


Pssm-ID: 183124  Cd Length: 433  Bit Score: 47.47  E-value: 1.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854   52 ILLGFQHYLTCFSGTIAVPFLLAEALCVGRDQHMVSQLIGTIFTcvGITTLIQTTVGIRLPLFQASAFAFLVPAKSILAL 131
Cdd:PRK11412  11 LLSGFQWFFFIFCNTVVVPPTLLSAFQLPQSSLLTLTQYAFLAT--ALACFAQAFCGHRRAIMEGPGGLWWGTILTITLG 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854  132 ERWKCPSEEEIYGNWSMplntshiwhprirevqgAIMVSSMVEVVIGLMGLPGALLSYIGP-------------LTVTPT 198
Cdd:PRK11412  89 EASRGTPINDIATSLAV-----------------GIALSGVVTILIGFSGLGHRLARLFTPmvmvvfmlllgaqLTTIFF 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854  199 VSLIGLSvFQAAGDRAGSHWGISACSILLIVLFSqylrnltfllpvyrwgkGLTLFRVQIFKMFPIVLAIMTVWLLCYVl 278
Cdd:PRK11412 152 KGMLGLP-FGIADPNGKIQLPPFGLSVAVMCLVL-----------------AMIIFLPQRIARYSLLVGTIVGWILWAF- 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854  279 tltdVLPADPTVYGfqartdarGDIMAISPWiriPYPCQWgLPTVTVAAVLgmfsATLAGIIESIGDYYACARLAGAPPP 358
Cdd:PRK11412 213 ----CFPSSHSLSG--------ELHWQWFPL---GSGGAL-EPGIILTAVI----TGLVNISNTYGAIRGTDVFYPQQGA 272
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854  359 PVHAINRGIFTEGICCIIAGLLGTGNGSTSSSpNIGVLGITKVGSRRVVQYGAGIMLILGAIGKFTALFASLPDPILGGM 438
Cdd:PRK11412 273 GNTRYRRSFVATGFMTLITVPLAVIPFSPFVS-SIGLLTQTGDYRRRSFIYGSVMCLLVALIPALTRLFCSIPLPVSSAV 351
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854  439 FCTLFGMITAVGLSNLQFVDMNsSRNLFVLGFSMFFGLTLPNYldsNPGAINtGIPevdQILTVLLTTEMFVGGCLAFIL 518
Cdd:PRK11412 352 MLVSYLPLLGSALVFSQQITFT-ARNIYRLALPLFVGIFLMAL---PPVYLQ-DLP---LTLRPLLSNGLLVGILLAVLM 423

                 ....*
gi 74180854  519 DNTVP 523
Cdd:PRK11412 424 ENLIP 428
NCS2_1 NF037981
purine/pyrimidine permease; Proteins of this family usually have 14 transmembrane domains. ...
52-475 8.00e-04

purine/pyrimidine permease; Proteins of this family usually have 14 transmembrane domains. They belong to the NSC2 superfamily transporters. They are specific purine and/or pyrimidine permeases.


Pssm-ID: 468300  Cd Length: 419  Bit Score: 42.27  E-value: 8.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854   52 ILLGFQHYLTCFSGTIAVPFLLAEALcvGRDQHMVSQLIGTIFTCVGITTLIQTTVGIRLPLFQAsafaflvPAK---SI 128
Cdd:NF037981   4 FLGGLQWMAFMIAASIAAPIAIADLF--HLNPAETAGLVQRTIFVLGIAGLLQALFGHRLPINEG-------PAGlwwGV 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854  129 LAlerwkcpseeeIYGNWSMPLNTSHIwhPRIREVQGAIMVSSMVEVVIGLMGLpgallsyIGPLTV--TPTVSLIGLS- 205
Cdd:NF037981  75 FT-----------IYAGLVGTLYSTNI--ETLQALQGAMLVSGVFFFLLSVTGL-------IDKLAVlfTPVVTFIYLLl 134
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854  206 -VFQAAGDRAGSHWGISACSI---LLIVLFSQYLRNLTFLLpvyrwgkglTLFRVQIFKMFPIVLAIMTVWLLCYVLTLT 281
Cdd:NF037981 135 lVLQLSGSFIKGMMGIGYEGNevdPLVFLLSLVVIILTFYF---------SRHKIKWIRQYSILLSLAGGWLLFALFGKA 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854  282 DVLPADPtvygfqartdargdimaiSPWIRIPYPCQWGLPTVTVAAVLGMFSATL---AGIIESIGDYYACARLAGAPPP 358
Cdd:NF037981 206 PAIAHTG------------------GSIISLPELFVFGPPVFDSGLIVTSFFITLlliANMLASIRVMEEVLKKFGKIEV 267
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180854  359 PVHAINRGiFTEGICCIIAGLLGTgNGSTSSSPNIGVLGITKVGSRRVVQYGAGIMLILGAIGKFTALFASLPDPIlgGM 438
Cdd:NF037981 268 SERYRQAG-FASGINQLLGGLFSA-IGSVPISGAAGFVATTGIPSLKPFIIGSLLVVIISLFPPLMNIFASLPAPV--GY 343
                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 74180854  439 FCTLFGMITAVGLSNLQF-VDMNSSRNLFVLGFSMFFG 475
Cdd:NF037981 344 AVTFVVFSKMVGLAFGELdKEENKERARFVIGIALLAG 381
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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