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Conserved domains on  [gi|74180520|dbj|BAE34193|]
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unnamed protein product, partial [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 10648429)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0003676|GO:0008270|GO:0003700
PubMed:  11179890|11361095|10940247|22803940|12665246
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 590-624 6.76e-09

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


:

Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 51.48  E-value: 6.76e-09
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 74180520    590 VTGFYCQLCEEFLGDPISGEQHVKGHQHNENYKKY 624
Cdd:smart00451   1 TGGFYCKLCNVTFTDEISVEAHLKGKKHKKNVKKR 35
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 520-554 1.08e-07

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


:

Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 48.40  E-value: 1.08e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 74180520    520 AGSHWCKDCNTTCGTMFDFFTHMHNKKHTQTLDPY 554
Cdd:smart00451   1 TGGFYCKLCNVTFTDEISVEAHLKGKKHKKNVKKR 35
MAD super family cl37733
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 339-470 3.60e-04

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


The actual alignment was detected with superfamily member pfam05557:

Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 43.58  E-value: 3.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180520   339 EKNRASQKQ-KVIEEREKLKteQEARQKKMfylttELERLHKQQGEMLRKKRREKDGhkdpLLMEVSRLQDSIMKDIAEL 417
Cdd:pfam05557  48 DRNQELQKRiRLLEKREAEA--EEALREQA-----ELNRLKKKYLEALNKKLNEKES----QLADAREVISCLKNELSEL 116

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 74180520   418 HKETEEAE----KKQSELDKVAQILgiDIFDKSLKSSNDSKESTEKPEKEKSKSPEK 470
Cdd:pfam05557 117 RRQIQRAElelqSTNSELEELQERL--DLLKAKASEAEQLRQNLEKQQSSLAEAEQR 171
 
Name Accession Description Interval E-value
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 590-624 6.76e-09

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 51.48  E-value: 6.76e-09
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 74180520    590 VTGFYCQLCEEFLGDPISGEQHVKGHQHNENYKKY 624
Cdd:smart00451   1 TGGFYCKLCNVTFTDEISVEAHLKGKKHKKNVKKR 35
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 520-554 1.08e-07

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 48.40  E-value: 1.08e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 74180520    520 AGSHWCKDCNTTCGTMFDFFTHMHNKKHTQTLDPY 554
Cdd:smart00451   1 TGGFYCKLCNVTFTDEISVEAHLKGKKHKKNVKKR 35
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 339-470 3.60e-04

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 43.58  E-value: 3.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180520   339 EKNRASQKQ-KVIEEREKLKteQEARQKKMfylttELERLHKQQGEMLRKKRREKDGhkdpLLMEVSRLQDSIMKDIAEL 417
Cdd:pfam05557  48 DRNQELQKRiRLLEKREAEA--EEALREQA-----ELNRLKKKYLEALNKKLNEKES----QLADAREVISCLKNELSEL 116

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 74180520   418 HKETEEAE----KKQSELDKVAQILgiDIFDKSLKSSNDSKESTEKPEKEKSKSPEK 470
Cdd:pfam05557 117 RRQIQRAElelqSTNSELEELQERL--DLLKAKASEAEQLRQNLEKQQSSLAEAEQR 171
PTZ00121 PTZ00121
MAEBL; Provisional
 334-466 5.23e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.59  E-value: 5.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180520   334 KKISDEKNRASQKQKViEEREKLKTEQEARQkkmfylttelERLHKQQGEMLRKKRREKDGHKDPLLMEVSRlqdsiMKD 413
Cdd:PTZ00121 1640 KKEAEEKKKAEELKKA-EEENKIKAAEEAKK----------AEEDKKKAEEAKKAEEDEKKAAEALKKEAEE-----AKK 1703

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 74180520   414 IAELHKETEEAEKKQSELDKVAQILGIDIFDKSLKSSNDSKESTE--KPEKEKSK 466
Cdd:PTZ00121 1704 AEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEakKDEEEKKK 1758
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
334-471 5.13e-03

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 39.51  E-value: 5.13e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180520 334 KKISDEKNRASQKQKVIEEREKLK-TEQEARQKKMfylttELERLHKQqgemLRKKRREKDGHKDpLLMEVSRLQDSIMK 412
Cdd:COG1340 140 EKIKELEKELEKAKKALEKNEKLKeLRAELKELRK-----EAEEIHKK----IKELAEEAQELHE-EMIELYKEADELRK 209

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74180520 413 DIAELHKETEEAEKKQSELDKVAQILGIDI--FDKSLKSSNDSKESTEKPEKEKSKSPEKE 471
Cdd:COG1340 210 EADELHKEIVEAQEKADELHEEIIELQKELreLRKELKKLRKKQRALKREKEKEELEEKAE 270
 
Name Accession Description Interval E-value
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 590-624 6.76e-09

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 51.48  E-value: 6.76e-09
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 74180520    590 VTGFYCQLCEEFLGDPISGEQHVKGHQHNENYKKY 624
Cdd:smart00451   1 TGGFYCKLCNVTFTDEISVEAHLKGKKHKKNVKKR 35
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 520-554 1.08e-07

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 48.40  E-value: 1.08e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 74180520    520 AGSHWCKDCNTTCGTMFDFFTHMHNKKHTQTLDPY 554
Cdd:smart00451   1 TGGFYCKLCNVTFTDEISVEAHLKGKKHKKNVKKR 35
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 339-470 3.60e-04

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 43.58  E-value: 3.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180520   339 EKNRASQKQ-KVIEEREKLKteQEARQKKMfylttELERLHKQQGEMLRKKRREKDGhkdpLLMEVSRLQDSIMKDIAEL 417
Cdd:pfam05557  48 DRNQELQKRiRLLEKREAEA--EEALREQA-----ELNRLKKKYLEALNKKLNEKES----QLADAREVISCLKNELSEL 116

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 74180520   418 HKETEEAE----KKQSELDKVAQILgiDIFDKSLKSSNDSKESTEKPEKEKSKSPEK 470
Cdd:pfam05557 117 RRQIQRAElelqSTNSELEELQERL--DLLKAKASEAEQLRQNLEKQQSSLAEAEQR 171
PTZ00121 PTZ00121
MAEBL; Provisional
 334-466 5.23e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.59  E-value: 5.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180520   334 KKISDEKNRASQKQKViEEREKLKTEQEARQkkmfylttelERLHKQQGEMLRKKRREKDGHKDPLLMEVSRlqdsiMKD 413
Cdd:PTZ00121 1640 KKEAEEKKKAEELKKA-EEENKIKAAEEAKK----------AEEDKKKAEEAKKAEEDEKKAAEALKKEAEE-----AKK 1703

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 74180520   414 IAELHKETEEAEKKQSELDKVAQILGIDIFDKSLKSSNDSKESTE--KPEKEKSK 466
Cdd:PTZ00121 1704 AEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEakKDEEEKKK 1758
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 326-469 9.15e-04

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 42.51  E-value: 9.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180520  326 PSLIKYNPKKISDEKNRASQkqkVIEEREKLKTEQEARQKKMFYLTTELERLHKQqgemLRKKRREKDGHKDPLLmevSR 405
Cdd:PRK00409 501 ENIIEEAKKLIGEDKEKLNE---LIASLEELERELEQKAEEAEALLKEAEKLKEE----LEEKKEKLQEEEDKLL---EE 570

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180520  406 LQDSIMKDIAELHKETEEAEKKQSELDK------VAQILgIDIfDKSLKSSNDSKESTEKPEKEKSKSPE 469
Cdd:PRK00409 571 AEKEAQQAIKEAKKEADEIIKELRQLQKggyasvKAHEL-IEA-RKRLNKANEKKEKKKKKQKEKQEELK 638
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
340-434 2.19e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 41.20  E-value: 2.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180520  340 KNRASQKQKVIEEREKLKTEQEARQKKMFYLTTELERLHKQQGEMLRK----KRREKDGHKDPLLMEVSRLQ-------- 407
Cdd:PRK03918 608 KDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKyseeEYEELREEYLELSRELAGLRaeleelek 687

                         90       100
                 ....*....|....*....|....*....
gi 74180520  408 --DSIMKDIAELHKETEEAEKKQSELDKV 434
Cdd:PRK03918 688 rrEEIKKTLEKLKEELEEREKAKKELEKL 716
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
334-471 5.13e-03

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 39.51  E-value: 5.13e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180520 334 KKISDEKNRASQKQKVIEEREKLK-TEQEARQKKMfylttELERLHKQqgemLRKKRREKDGHKDpLLMEVSRLQDSIMK 412
Cdd:COG1340 140 EKIKELEKELEKAKKALEKNEKLKeLRAELKELRK-----EAEEIHKK----IKELAEEAQELHE-EMIELYKEADELRK 209

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74180520 413 DIAELHKETEEAEKKQSELDKVAQILGIDI--FDKSLKSSNDSKESTEKPEKEKSKSPEKE 471
Cdd:COG1340 210 EADELHKEIVEAQEKADELHEEIIELQKELreLRKELKKLRKKQRALKREKEKEELEEKAE 270
PTZ00121 PTZ00121
MAEBL; Provisional
 330-469 9.79e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 39.35  E-value: 9.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74180520   330 KYNPKKISDEKNRASQKQKVIEEREKLKTEQEARQKKmfylttELERLHKQQGEMLRKKRREKDgHKDpllmEVSRLQDS 409
Cdd:PTZ00121 1285 KAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAK------KKAEEAKKKADAAKKKAEEAK-KAA----EAAKAEAE 1353

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74180520   410 IMKDIAELHKETEEA-EKKQSELDKVAqilgiDIFDKSLKSSNDSKESTEKPEKEKSKSPE 469
Cdd:PTZ00121 1354 AAADEAEAAEEKAEAaEKKKEEAKKKA-----DAAKKKAEEKKKADEAKKKAEEDKKKADE 1409
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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