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Conserved domains on  [gi|739769579|ref|WP_037621858|]
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MULTISPECIES: D-alanyl-D-alanine carboxypeptidase PBP3 [Streptococcus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
strep_PBP3 super family cl45725
streptococcal D-alanyl-D-alanine carboxypeptidase PBP3; PBP3 (penicillin-binding protein 3) is ...
 2-414 0e+00

streptococcal D-alanyl-D-alanine carboxypeptidase PBP3; PBP3 (penicillin-binding protein 3) is the lone D-alanyl-D-alanine carboxypeptidase in Streptococcus pneumoniae. The gene is known as pbp3 or dacA.


The actual alignment was detected with superfamily member NF038273:

Pssm-ID: 468443 [Multi-domain]  Cd Length: 407  Bit Score: 678.51  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579   2 KKLITLMMTFLLCLgSVAPAFAADkkkgYDAAAKHAVAVEANTGKILYEKDATTSAGIGSITKLLTAYMVYKAVDQGDLK 81
Cdd:NF038273   1 KKLILLLLLLLAFF-LATTVSADD----FDVAAKHAIAVEANTGKILYEKDATTPVPIASLTKLLTAYLVYKEIKSGKLS 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579  82 WNSKVDISDYPFELTVSAGVSNIPLDARKYTVKQLLDATLIASANSASIALAEEIGGTESKFVDMMKAQLKDWGITDAKI 161
Cdd:NF038273  76 WDTPVKISDYPYELTTNYEISNVPLDARKYTVKELLEASLVASANSAAIALAEKIAGSEPKFVDKMKAQLKEWGITDAKL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579 162 VNASGLNNSYLGDNIYPGSKSDEENTMSAKDVAVIAQHVVKEYPEILDITKKTEADFDGvNKLKTSNYMLKGQPSYRKGV 241
Cdd:NF038273 156 VNASGLNNSYLGDHIYPGSKKDDENKLSAKDVAIIARHLIKDFPEVLKITSKTSADFAG-TTIYSYNYMLKGMPYYREGV 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579 242 DGLKTGTTDLAGASFVAHSNESGMSIIAVILNSDNTDTDDYARFTATNDLLNYVVYHWESKTIAKKGQAIGKSQASVLDG 321
Cdd:NF038273 235 DGLKTGTTEKAGASFVATSVENGMRVITVVLNADNADEDEYARFTATNQLLDYIYQNFEKVTLVKKGQAYKDSKLPVIDG 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579 322 KSKQVTAVAKSDFNIIQKIDANNNKHIKVTTNQ--MQAPVKAGDKVGTATFEDKDLVGEGYLpnQGMPSMELVAGKEVKK 399
Cdd:NF038273 315 KKKTVSAVAKKDLTVIQKIGTDSKPSVKFTPKKkeLTAPIKKGQVVGKATFKDKDLIGKGYL--GEPPSVELVAKKDVKK 392

                        410
                 ....*....|....*
gi 739769579 400 SFFLKVWWNHFVTFV 414
Cdd:NF038273 393 SFFLKVWWNHFVRYV 407
 
Name Accession Description Interval E-value
strep_PBP3 NF038273
streptococcal D-alanyl-D-alanine carboxypeptidase PBP3; PBP3 (penicillin-binding protein 3) is ...
 2-414 0e+00

streptococcal D-alanyl-D-alanine carboxypeptidase PBP3; PBP3 (penicillin-binding protein 3) is the lone D-alanyl-D-alanine carboxypeptidase in Streptococcus pneumoniae. The gene is known as pbp3 or dacA.


Pssm-ID: 468443 [Multi-domain]  Cd Length: 407  Bit Score: 678.51  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579   2 KKLITLMMTFLLCLgSVAPAFAADkkkgYDAAAKHAVAVEANTGKILYEKDATTSAGIGSITKLLTAYMVYKAVDQGDLK 81
Cdd:NF038273   1 KKLILLLLLLLAFF-LATTVSADD----FDVAAKHAIAVEANTGKILYEKDATTPVPIASLTKLLTAYLVYKEIKSGKLS 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579  82 WNSKVDISDYPFELTVSAGVSNIPLDARKYTVKQLLDATLIASANSASIALAEEIGGTESKFVDMMKAQLKDWGITDAKI 161
Cdd:NF038273  76 WDTPVKISDYPYELTTNYEISNVPLDARKYTVKELLEASLVASANSAAIALAEKIAGSEPKFVDKMKAQLKEWGITDAKL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579 162 VNASGLNNSYLGDNIYPGSKSDEENTMSAKDVAVIAQHVVKEYPEILDITKKTEADFDGvNKLKTSNYMLKGQPSYRKGV 241
Cdd:NF038273 156 VNASGLNNSYLGDHIYPGSKKDDENKLSAKDVAIIARHLIKDFPEVLKITSKTSADFAG-TTIYSYNYMLKGMPYYREGV 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579 242 DGLKTGTTDLAGASFVAHSNESGMSIIAVILNSDNTDTDDYARFTATNDLLNYVVYHWESKTIAKKGQAIGKSQASVLDG 321
Cdd:NF038273 235 DGLKTGTTEKAGASFVATSVENGMRVITVVLNADNADEDEYARFTATNQLLDYIYQNFEKVTLVKKGQAYKDSKLPVIDG 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579 322 KSKQVTAVAKSDFNIIQKIDANNNKHIKVTTNQ--MQAPVKAGDKVGTATFEDKDLVGEGYLpnQGMPSMELVAGKEVKK 399
Cdd:NF038273 315 KKKTVSAVAKKDLTVIQKIGTDSKPSVKFTPKKkeLTAPIKKGQVVGKATFKDKDLIGKGYL--GEPPSVELVAKKDVKK 392

                        410
                 ....*....|....*
gi 739769579 400 SFFLKVWWNHFVTFV 414
Cdd:NF038273 393 SFFLKVWWNHFVRYV 407
DacC COG1686
D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis];
1-333 8.70e-85

D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441292 [Multi-domain]  Cd Length: 324  Bit Score: 261.69  E-value: 8.70e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579   1 MKKLITLMMTFLLCLGSVAPAFAadkkkgYDAAAKHAVAVEANTGKILYEKDATTSAGIGSITKLLTAYMVYKAVDQGDL 80
Cdd:COG1686    1 MKKLLLLALLLLLAAAAAAPAAP------PDIAAKSAILIDADTGQVLYEKNADERLPPASLTKLMTAYVVLEALKAGKI 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579  81 KWNSKVDISDYpfelTVSAGVSNIPLDAR-KYTVKQLLDATLIASANSASIALAEEIGGTESKFVDMMKAQLKDWGITDA 159
Cdd:COG1686   75 SLDDKVTVSEE----AARTGGSKMGLKPGeQVTVEDLLKGLLLQSGNDAAVALAEHIAGSEEAFVALMNAKAKELGMTNT 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579 160 KIVNASGLnnsylgdniypgskSDEENTMSAKDVAVIAQHVVKEYPEILDITKKTEADFDGVNK--LKTSNYMLKGQPsy 237
Cdd:COG1686  151 HFVNPTGL--------------PDPGHYSTARDLALLARAAIKDYPEFYEIFSTKEFTFPNGRGitLRNTNRLLGRYP-- 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579 238 rkGVDGLKTGTTDLAGASFVAHSNESGMSIIAVILNSDntdtDDYARFTATNDLLNY-----------VVYHWESKTIAK 306
Cdd:COG1686  215 --GVDGLKTGYTDAAGYCLVASAKRGGRRLIAVVLGAP----SEKARFADAAKLLDYgfpkgealkaeVVLDGPLKAPVK 288

                        330       340
                 ....*....|....*....|....*..
gi 739769579 307 KGQAIGKSQASVLDGKSKQVTAVAKSD 333
Cdd:COG1686  289 KGQVVGTLVVTLDGKTIAEVPLVAAED 315
Peptidase_S11 pfam00768
D-alanyl-D-alanine carboxypeptidase;
31-275 1.60e-66

D-alanyl-D-alanine carboxypeptidase;


Pssm-ID: 425859 [Multi-domain]  Cd Length: 234  Bit Score: 211.86  E-value: 1.60e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579   31 DAAAKHAVAVEANTGKILYEKDATTSAGIGSITKLLTAYMVYKAVDQGDLKWNSKVDISDYPFELTVSaGVSNIPLDAR- 109
Cdd:pfam00768   5 EIAAKSAILVDYNTGKVLYEKNPDQVRPIASITKLMTAYVVLEALKAGKIKEDDMVTISEDAWATGNP-GSSNIFLKPGs 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579  110 KYTVKQLLDATLIASANSASIALAEEIGGTESKFVDMMKAQLKDWGITDAKIVNASGLnnsylgdniypgskSDEENTMS 189
Cdd:pfam00768  84 QVSVKDLLRGALVSSGNDAAVALAEHIAGSEKAFVK*MNAKAKELGLKNTRFVNPTGL--------------DAHGQYSS 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579  190 AKDVAVIAQHVVKEYPEILDITKKTEADFDGVNKLktsNYMLKGQPSYRKG--VDGLKTGTTDLAGASFVAHSNESGMSI 267
Cdd:pfam00768 150 ARDMAILAKALIKDLPEELSITKEKSFTFRGINKI---NQRNRNGLLWDKTwnVDGLKTGYTNEAGYCLVASATKGGMRL 226


                  ....*...
gi 739769579  268 IAVILNSD 275
Cdd:pfam00768 227 ISVVMGAF 234
PRK10001 PRK10001
serine-type D-Ala-D-Ala carboxypeptidase;
20-406 1.02e-25

serine-type D-Ala-D-Ala carboxypeptidase;


Pssm-ID: 182189 [Multi-domain]  Cd Length: 400  Bit Score: 107.77  E-value: 1.02e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579  20 PAFAADKK-KGYDAAAKHAVAVEANTGKILYEKDATTSAGIGSITKLLTAYMVYKAVDQGDLKWNSKVDISDYPFELTVS 98
Cdd:PRK10001  24 TAFAAEQTvEAPSVDARAWILMDYASGKVLAEGNADEKLDPASLTKIMTSYVVGQALKADKIKLTDMVTVGKDAWATGNP 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579  99 A--GVSNIPLD-ARKYTVKQLLDATLIASANSASIALAEEIGGTESKFVDMMKAQLKDWGITDAKIVNASGLNNsylgdn 175
Cdd:PRK10001 104 AlrGSSVMFLKpGDQVSVADLNKGVIIQSGNDACIALADYVAGSQESFIGLMNGYAKKLGLTNTTFQTVHGLDA------ 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579 176 iyPGSKSdeentmSAKDVAVIAQHVVKEYPEILDITKKTEADFDGVNKlKTSNYMLKgqpSYRKGVDGLKTGTTDLAGAS 255
Cdd:PRK10001 178 --PGQFS------TARDMALLGKALIHDVPEEYAIHKEKEFTFNKIRQ-PNRNRLLW---SSNLNVDGMKTGTTAGAGYN 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579 256 FVAHSNESGMSIIAVILNSDNtdtdDYARFTATNDLLNYVVYHWESKTIAKKGQAIGKSQASVLDGKSKQVTAVAKSDFN 335
Cdd:PRK10001 246 LVASATQGDMRLISVVLGAKT----DRIRFNESEKLLTWGFRFFETVTPIKPDATFVTQRVWFGDKSEVNLGAGEAGSVT 321

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 739769579 336 IIQKIDANNNKHIKVTTNQMQAPVKAGDKVGTATFEdkdlvgegyLPNQGMPSMELVAGKEVKK-SFFLKVW 406
Cdd:PRK10001 322 IPRGQLKNLKASYTLTEPQLTAPLKKGQVVGTIDFQ---------LNGKSIEQRPLIVMENVEEgGFFSRMW 384
PBP5_C smart00936
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. ...
 299-399 8.98e-14

Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. coli functions as a D-alanyl-D-alanine carboxypeptidase. It is composed of two domains that are oriented at approximately right angles to each other. The N-terminal domain (pfam00768) is the catalytic domain. The C-terminal domain featured in this family is organized into a sandwich of two anti-parallel beta-sheets, and has a relatively hydrophobic surface as compared to the N-terminal domain. Its precise function is unknown; it may mediate interactions with other cell wall-synthesising enzymes, thus allowing the protein to be recruited to areas of active cell wall synthesis. It may also function as a linker domain that positions the active site in the catalytic domain closer to the peptidoglycan layer, to allow it to interact with cell wall peptides.


Pssm-ID: 198004 [Multi-domain]  Cd Length: 92  Bit Score: 66.47  E-value: 8.98e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579   299 WESKTIAKKGQAIGKsqASVLDGKSKQVTAVAKSDFNIIQKIDANNNKHIKVTTNQ--MQAPVKAGDKVGTATFedkdlv 376
Cdd:smart00936   1 FETVKLYKKGQVVGT--VKVWKGKEKTVKLGAKEDVYVTLPKGEKKKLKAKVVLDKpeLEAPIKKGQVVGTLVV------ 72

                           90       100
                   ....*....|....*....|...
gi 739769579   377 gegYLPNQGMPSMELVAGKEVKK 399
Cdd:smart00936  73 ---TLDGKLIGEVPLVALEDVEK 92
 
Name Accession Description Interval E-value
strep_PBP3 NF038273
streptococcal D-alanyl-D-alanine carboxypeptidase PBP3; PBP3 (penicillin-binding protein 3) is ...
 2-414 0e+00

streptococcal D-alanyl-D-alanine carboxypeptidase PBP3; PBP3 (penicillin-binding protein 3) is the lone D-alanyl-D-alanine carboxypeptidase in Streptococcus pneumoniae. The gene is known as pbp3 or dacA.


Pssm-ID: 468443 [Multi-domain]  Cd Length: 407  Bit Score: 678.51  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579   2 KKLITLMMTFLLCLgSVAPAFAADkkkgYDAAAKHAVAVEANTGKILYEKDATTSAGIGSITKLLTAYMVYKAVDQGDLK 81
Cdd:NF038273   1 KKLILLLLLLLAFF-LATTVSADD----FDVAAKHAIAVEANTGKILYEKDATTPVPIASLTKLLTAYLVYKEIKSGKLS 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579  82 WNSKVDISDYPFELTVSAGVSNIPLDARKYTVKQLLDATLIASANSASIALAEEIGGTESKFVDMMKAQLKDWGITDAKI 161
Cdd:NF038273  76 WDTPVKISDYPYELTTNYEISNVPLDARKYTVKELLEASLVASANSAAIALAEKIAGSEPKFVDKMKAQLKEWGITDAKL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579 162 VNASGLNNSYLGDNIYPGSKSDEENTMSAKDVAVIAQHVVKEYPEILDITKKTEADFDGvNKLKTSNYMLKGQPSYRKGV 241
Cdd:NF038273 156 VNASGLNNSYLGDHIYPGSKKDDENKLSAKDVAIIARHLIKDFPEVLKITSKTSADFAG-TTIYSYNYMLKGMPYYREGV 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579 242 DGLKTGTTDLAGASFVAHSNESGMSIIAVILNSDNTDTDDYARFTATNDLLNYVVYHWESKTIAKKGQAIGKSQASVLDG 321
Cdd:NF038273 235 DGLKTGTTEKAGASFVATSVENGMRVITVVLNADNADEDEYARFTATNQLLDYIYQNFEKVTLVKKGQAYKDSKLPVIDG 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579 322 KSKQVTAVAKSDFNIIQKIDANNNKHIKVTTNQ--MQAPVKAGDKVGTATFEDKDLVGEGYLpnQGMPSMELVAGKEVKK 399
Cdd:NF038273 315 KKKTVSAVAKKDLTVIQKIGTDSKPSVKFTPKKkeLTAPIKKGQVVGKATFKDKDLIGKGYL--GEPPSVELVAKKDVKK 392

                        410
                 ....*....|....*
gi 739769579 400 SFFLKVWWNHFVTFV 414
Cdd:NF038273 393 SFFLKVWWNHFVRYV 407
DacC COG1686
D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis];
1-333 8.70e-85

D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441292 [Multi-domain]  Cd Length: 324  Bit Score: 261.69  E-value: 8.70e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579   1 MKKLITLMMTFLLCLGSVAPAFAadkkkgYDAAAKHAVAVEANTGKILYEKDATTSAGIGSITKLLTAYMVYKAVDQGDL 80
Cdd:COG1686    1 MKKLLLLALLLLLAAAAAAPAAP------PDIAAKSAILIDADTGQVLYEKNADERLPPASLTKLMTAYVVLEALKAGKI 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579  81 KWNSKVDISDYpfelTVSAGVSNIPLDAR-KYTVKQLLDATLIASANSASIALAEEIGGTESKFVDMMKAQLKDWGITDA 159
Cdd:COG1686   75 SLDDKVTVSEE----AARTGGSKMGLKPGeQVTVEDLLKGLLLQSGNDAAVALAEHIAGSEEAFVALMNAKAKELGMTNT 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579 160 KIVNASGLnnsylgdniypgskSDEENTMSAKDVAVIAQHVVKEYPEILDITKKTEADFDGVNK--LKTSNYMLKGQPsy 237
Cdd:COG1686  151 HFVNPTGL--------------PDPGHYSTARDLALLARAAIKDYPEFYEIFSTKEFTFPNGRGitLRNTNRLLGRYP-- 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579 238 rkGVDGLKTGTTDLAGASFVAHSNESGMSIIAVILNSDntdtDDYARFTATNDLLNY-----------VVYHWESKTIAK 306
Cdd:COG1686  215 --GVDGLKTGYTDAAGYCLVASAKRGGRRLIAVVLGAP----SEKARFADAAKLLDYgfpkgealkaeVVLDGPLKAPVK 288

                        330       340
                 ....*....|....*....|....*..
gi 739769579 307 KGQAIGKSQASVLDGKSKQVTAVAKSD 333
Cdd:COG1686  289 KGQVVGTLVVTLDGKTIAEVPLVAAED 315
Peptidase_S11 pfam00768
D-alanyl-D-alanine carboxypeptidase;
31-275 1.60e-66

D-alanyl-D-alanine carboxypeptidase;


Pssm-ID: 425859 [Multi-domain]  Cd Length: 234  Bit Score: 211.86  E-value: 1.60e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579   31 DAAAKHAVAVEANTGKILYEKDATTSAGIGSITKLLTAYMVYKAVDQGDLKWNSKVDISDYPFELTVSaGVSNIPLDAR- 109
Cdd:pfam00768   5 EIAAKSAILVDYNTGKVLYEKNPDQVRPIASITKLMTAYVVLEALKAGKIKEDDMVTISEDAWATGNP-GSSNIFLKPGs 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579  110 KYTVKQLLDATLIASANSASIALAEEIGGTESKFVDMMKAQLKDWGITDAKIVNASGLnnsylgdniypgskSDEENTMS 189
Cdd:pfam00768  84 QVSVKDLLRGALVSSGNDAAVALAEHIAGSEKAFVK*MNAKAKELGLKNTRFVNPTGL--------------DAHGQYSS 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579  190 AKDVAVIAQHVVKEYPEILDITKKTEADFDGVNKLktsNYMLKGQPSYRKG--VDGLKTGTTDLAGASFVAHSNESGMSI 267
Cdd:pfam00768 150 ARDMAILAKALIKDLPEELSITKEKSFTFRGINKI---NQRNRNGLLWDKTwnVDGLKTGYTNEAGYCLVASATKGGMRL 226


                  ....*...
gi 739769579  268 IAVILNSD 275
Cdd:pfam00768 227 ISVVMGAF 234
PRK10001 PRK10001
serine-type D-Ala-D-Ala carboxypeptidase;
20-406 1.02e-25

serine-type D-Ala-D-Ala carboxypeptidase;


Pssm-ID: 182189 [Multi-domain]  Cd Length: 400  Bit Score: 107.77  E-value: 1.02e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579  20 PAFAADKK-KGYDAAAKHAVAVEANTGKILYEKDATTSAGIGSITKLLTAYMVYKAVDQGDLKWNSKVDISDYPFELTVS 98
Cdd:PRK10001  24 TAFAAEQTvEAPSVDARAWILMDYASGKVLAEGNADEKLDPASLTKIMTSYVVGQALKADKIKLTDMVTVGKDAWATGNP 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579  99 A--GVSNIPLD-ARKYTVKQLLDATLIASANSASIALAEEIGGTESKFVDMMKAQLKDWGITDAKIVNASGLNNsylgdn 175
Cdd:PRK10001 104 AlrGSSVMFLKpGDQVSVADLNKGVIIQSGNDACIALADYVAGSQESFIGLMNGYAKKLGLTNTTFQTVHGLDA------ 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579 176 iyPGSKSdeentmSAKDVAVIAQHVVKEYPEILDITKKTEADFDGVNKlKTSNYMLKgqpSYRKGVDGLKTGTTDLAGAS 255
Cdd:PRK10001 178 --PGQFS------TARDMALLGKALIHDVPEEYAIHKEKEFTFNKIRQ-PNRNRLLW---SSNLNVDGMKTGTTAGAGYN 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579 256 FVAHSNESGMSIIAVILNSDNtdtdDYARFTATNDLLNYVVYHWESKTIAKKGQAIGKSQASVLDGKSKQVTAVAKSDFN 335
Cdd:PRK10001 246 LVASATQGDMRLISVVLGAKT----DRIRFNESEKLLTWGFRFFETVTPIKPDATFVTQRVWFGDKSEVNLGAGEAGSVT 321

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 739769579 336 IIQKIDANNNKHIKVTTNQMQAPVKAGDKVGTATFEdkdlvgegyLPNQGMPSMELVAGKEVKK-SFFLKVW 406
Cdd:PRK10001 322 IPRGQLKNLKASYTLTEPQLTAPLKKGQVVGTIDFQ---------LNGKSIEQRPLIVMENVEEgGFFSRMW 384
dacD PRK11397
serine-type D-Ala-D-Ala carboxypeptidase DacD;
7-399 1.40e-22

serine-type D-Ala-D-Ala carboxypeptidase DacD;


Pssm-ID: 183117 [Multi-domain]  Cd Length: 388  Bit Score: 98.35  E-value: 1.40e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579   7 LMMTFLLCLGSVAPAFAAD------KKKGYDAAAkhAVAVEANTGKILYEKDATTSAGIGSITKLLTAYMVYKAVDQGDL 80
Cdd:PRK11397   5 LIIAASLFAFNLSSAFAAEnipfspQPPAIDAGS--WVLMDYTTGQILTAGNEHQQRNPASLTKLMTGYVVDRAIDSHRI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579  81 KWNSKVDI------SDYPfeltVSAGVSNIPLDA-RKYTVKQLLDATLIASANSASIALAEEIGGTESKFVDMMKAQLKD 153
Cdd:PRK11397  83 TPDDIVTVgrdawaKDNP----VFVGSSLMFLKEgDRVSVRDLSRGLIVDSGNDACVALADYIAGGQRQFVEMMNNYVEK 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579 154 WGITDAKIVNASGLNNsylgdniyPGSKSdeentmSAKDVAVIAQHVVKEYPEILDITKKTEADFDGVNKlKTSNYMLKG 233
Cdd:PRK11397 159 LHLKDTHFETVHGLDA--------PGQHS------SAYDLAVLSRAIIHGEPEFYHMYSEKSLTWNGITQ-QNRNGLLWD 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579 234 QPSYrkgVDGLKTGTTDLAGASFVAHSNESGMSIIAVILNSDNTD-TDDYARftatnDLLNYVVYHWESKTIAKKGQAIG 312
Cdd:PRK11397 224 KTMN---VDGLKTGHTSGAGFNLIASAVDGQRRLIAVVMGADSAKgREEQAR-----KLLRWGQQNFTTVQILHRGKKVG 295

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579 313 ksQASVLDGKSKQVTAVAKSDFNI------IQKIDAnnnKHIkVTTNQMQAPVKAGDKVGTATFEDKDLVgegylpnqgM 386
Cdd:PRK11397 296 --TERIWYGDKENIALGTEQDFWMvlpkaeIPHIKA---KYV-LDGKELEAPISAHQRVGEIELYDRDKQ---------V 360

                        410
                 ....*....|...
gi 739769579 387 PSMELVAGKEVKK 399
Cdd:PRK11397 361 AHWPLVTLESVGE 373
PRK10793 PRK10793
D-alanyl-D-alanine carboxypeptidase fraction A; Provisional
 1-371 1.39e-19

D-alanyl-D-alanine carboxypeptidase fraction A; Provisional


Pssm-ID: 182736 [Multi-domain]  Cd Length: 403  Bit Score: 89.91  E-value: 1.39e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579   1 MKKLIT------LMMTFLLCLGSVAPAFAADKKKGY------DAAAKHAVAVEANTGKILYEKDATTSAGIGSITKLLTA 68
Cdd:PRK10793   1 MKTIFSarimkrLALTTALCTAFISAAHADDLNIKTmipgvpQIDAESYILIDYNSGKVLAEQNADVRRDPASLTKMMTS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579  69 YMVYKAVDQGDLKWNSKVDISDYPFEL--TVSAGVSNIPLD-ARKYTVKQLLDATLIASANSASIALAEEIGGTESKFVD 145
Cdd:PRK10793  81 YVIGQAMKAGKFKETDLVTVGNDAWATgnPVFKGSSLMFLKpGMQVPVSQLIRGINLQSGNDACVAMADYVAGSQDAFVG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579 146 MMKAQLKDWGITDAKIVNASGLNNsylgdniyPGSKSdeentmSAKDVAVIAQHVVKEYPEILDITKKTEADFDGVNKLK 225
Cdd:PRK10793 161 LMNSYVNALGLKNTHFQTVHGLDA--------DGQYS------SARDMALIGQALIRDVPNEYAIYKEKEFTFNGIRQLN 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579 226 TSNYMLKGQPSyrkgVDGLKTGTTDLAGASFVAHSNESGMSIIAVILNSDNTDtddyARFTATNDLLNYVVYHWESKTIA 305
Cdd:PRK10793 227 RNGLLWDNSLN----VDGIKTGHTDKAGYNLVASATEGQMRLISAVMGGRTFK----GRETESKKLLTWGFRFFETVNPL 298

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 739769579 306 KKGQAIGKSQASVLDGKSKQVtAVAKSDFNIIQKIDANNNKHIKVTTN-QMQAPVKAGDKVGTATFE 371
Cdd:PRK10793 299 KVGKEFASEPVWFGDSDRASL-GVDKDVYLTIPRGRMKDLKASYVLNTsELHAPLQKNQVVGTINFQ 364
PBP5_C smart00936
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. ...
 299-399 8.98e-14

Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. coli functions as a D-alanyl-D-alanine carboxypeptidase. It is composed of two domains that are oriented at approximately right angles to each other. The N-terminal domain (pfam00768) is the catalytic domain. The C-terminal domain featured in this family is organized into a sandwich of two anti-parallel beta-sheets, and has a relatively hydrophobic surface as compared to the N-terminal domain. Its precise function is unknown; it may mediate interactions with other cell wall-synthesising enzymes, thus allowing the protein to be recruited to areas of active cell wall synthesis. It may also function as a linker domain that positions the active site in the catalytic domain closer to the peptidoglycan layer, to allow it to interact with cell wall peptides.


Pssm-ID: 198004 [Multi-domain]  Cd Length: 92  Bit Score: 66.47  E-value: 8.98e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579   299 WESKTIAKKGQAIGKsqASVLDGKSKQVTAVAKSDFNIIQKIDANNNKHIKVTTNQ--MQAPVKAGDKVGTATFedkdlv 376
Cdd:smart00936   1 FETVKLYKKGQVVGT--VKVWKGKEKTVKLGAKEDVYVTLPKGEKKKLKAKVVLDKpeLEAPIKKGQVVGTLVV------ 72

                           90       100
                   ....*....|....*....|...
gi 739769579   377 gegYLPNQGMPSMELVAGKEVKK 399
Cdd:smart00936  73 ---TLDGKLIGEVPLVALEDVEK 92
PenP COG2367
Beta-lactamase class A [Defense mechanisms];
60-202 3.18e-10

Beta-lactamase class A [Defense mechanisms];


Pssm-ID: 441934 [Multi-domain]  Cd Length: 276  Bit Score: 60.68  E-value: 3.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579  60 GSITKLLTAYMVYKAVDQGDLKWNSKVDISDYpfELTVSAGVSNIPLDARKYTVKQLLDATLIASANSASIALAEEIGGt 139
Cdd:COG2367   59 ASTFKLPVLAAVLRQVDAGKLSLDERVTLTPE--DLVGGSGILQKLPDGTGLTLRELAELMITVSDNTATNLLLRLLGP- 135

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 739769579 140 eskfvDMMKAQLKDWGITDAKIVNASGLNNSYLGdniypgsksDEENTMSAKDVAVIAQHVVK 202
Cdd:COG2367  136 -----DAVNAFLRSLGLTDTRLDRKEPDLNELPG---------DGRNTTTPRDMARLLAALYR 184
PBP5_C pfam07943
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. ...
 299-399 7.77e-10

Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. coli functions as a D-alanyl-D-alanine carboxypeptidase. It is composed of two domains that are oriented at approximately right angles to each other. The N-terminal domain (pfam00768) is the catalytic domain. The C-terminal domain featured in this family is organized into a sandwich of two anti-parallel beta-sheets, and has a relatively hydrophobic surface as compared to the N-terminal domain. Its precise function is unknown; it may mediate interactions with other cell wall-synthesising enzymes, thus allowing the protein to be recruited to areas of active cell wall synthesis. It may also function as a linker domain that positions the active site in the catalytic domain closer to the peptidoglycan layer, to allow it to interact with cell wall peptides.


Pssm-ID: 429749 [Multi-domain]  Cd Length: 91  Bit Score: 55.29  E-value: 7.77e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579  299 WESKTIAKKGQAIGKsqASVLDGKSKQVTAVAKSDFNIIQKIDANNNKHIKVT-TNQMQAPVKAGDKVGTATFE-DKDLV 376
Cdd:pfam07943   1 FETKKLYKKGDVVKK--VKVWKGKKKTVPLGAKEDVYVTVPKGEKKKLKAKVTlKKPLEAPIKKGQVVGKLEVYlDGKLI 78

                          90       100
                  ....*....|....*....|...
gi 739769579  377 GEgylpnqgmpsMELVAGKEVKK 399
Cdd:pfam07943  79 GE----------VPLVAKEDVEE 91
pbpG PRK11669
D-alanyl-D-alanine endopeptidase; Provisional
 2-218 6.50e-09

D-alanyl-D-alanine endopeptidase; Provisional


Pssm-ID: 236952  Cd Length: 306  Bit Score: 57.00  E-value: 6.50e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579   2 KKLITLMMTFLLCLGSV---APAFAADKKKGYDAAAKH-----AVAVEANTGKILYEKDATTSAGIGSITKLLTAYMVYK 73
Cdd:PRK11669   1 MKFRVSLLSLLLLLAGVpfaPQAVAKTAAATTASQPQEiasgsAMVVDLNTNKVIYSSNPDLVVPIASITKLMTAMVVLD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579  74 AVDQGDLKWnsKVDISDYPfELTvsaGV-SNIPLDArKYTVKQLLDATLIASANSASIALAEEIGGTESKFVDMMKAQLK 152
Cdd:PRK11669  81 AKLPLDEKL--KVDISQTP-EMK---GVySRVRLNS-EISRKDMLLLALMSSENRAAASLAHHYPGGYKAFIKAMNAKAK 153

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 739769579 153 DWGITDAKIVNASGLNnsylgdniypgsksdEENTMSAKDVAVIAQhVVKEYPEI--LDITKKTEADF 218
Cdd:PRK11669 154 ALGMTNTRYVEPTGLS---------------IHNVSTARDLTKLLI-ASKQYPLIgqLSTTREKTATF 205
Beta-lactamase2 pfam13354
Beta-lactamase enzyme family; This is the catalytic domain of class A beta-lactamases. It is ...
 60-217 1.62e-07

Beta-lactamase enzyme family; This is the catalytic domain of class A beta-lactamases. It is closely related to Beta-lactamase, pfam00144, the serine beta-lactamase-like superfamily, which contains the distantly related pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.


Pssm-ID: 463854 [Multi-domain]  Cd Length: 215  Bit Score: 51.51  E-value: 1.62e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579   60 GSITKLLTAYMVYKAVDQGDLKWNSKVDISDypfELTVS-AGVSNIPLDARKYTVKQLLDATLIASANSASIALAEEIGg 138
Cdd:pfam13354  24 ASTIKVPILLAVLEQVDEGKLSLDERLTVTA---EDKVGgSGILQYLPDGSQLSLRDLLTLMIAVSDNTATNLLIDRLG- 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579  139 teskfVDMMKAQLKDWGITDAKIvnasglnNSYLGDniYPGSKSDEENTMSAKDVAVIAQHVV-------KEYPEILDIT 211
Cdd:pfam13354 100 -----LEAVNARLRALGLRDTRL-------RRKLPD--LRAADKGGTNTTTARDMAKLLEALYrgellspESTDRLLDIL 165


                  ....*.
gi 739769579  212 KKTEAD 217
Cdd:pfam13354 166 SRQQFR 171
AmpC COG1680
CubicO group peptidase, beta-lactamase class C family [Defense mechanisms];
36-117 1.84e-06

CubicO group peptidase, beta-lactamase class C family [Defense mechanisms];


Pssm-ID: 441286 [Multi-domain]  Cd Length: 355  Bit Score: 49.68  E-value: 1.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579  36 HAVAVEANtGKILYEK-------------DATTSAGIGSITKLLTAYMVYKAVDQGDLKWNSKVD--ISDYPFELTVSAG 100
Cdd:COG1680   35 AAVAVVRD-GKVVYEKaygvadletgrpvTPDTLFRIASVTKSFTATAVLQLVEEGKLDLDDPVSkyLPEFKLPDDAKRD 113

                         90
                 ....*....|....*..
gi 739769579 101 VsnipldarkyTVKQLL 117
Cdd:COG1680  114 I----------TVRHLL 120
Beta-lactamase pfam00144
Beta-lactamase; This family appears to be distantly related to pfam00905 and PF00768 ...
 37-120 6.83e-06

Beta-lactamase; This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.


Pssm-ID: 395092 [Multi-domain]  Cd Length: 327  Bit Score: 47.50  E-value: 6.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739769579   37 AVAVeANTGKILYEK-------------DATTSAGIGSITKLLTAYMVYKAVDQGDLKWNSKVdiSDYPFELTVSAGvsn 103
Cdd:pfam00144  18 AVAV-TRDGKVVVDRgggvadleggrpvTADTLFRIASVTKTFTAAAVLQLVERGKLDLDDPV--SKYLPEFAGPGK--- 91

                          90
                  ....*....|....*..
gi 739769579  104 ipldaRKYTVKQLLDAT 120
Cdd:pfam00144  92 -----GGITLRDLLTHT 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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