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Conserved domains on  [gi|739751183|ref|WP_037604033|]
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MULTISPECIES: polysaccharide biosynthesis protein [Streptococcus]

Protein Classification

polysaccharide biosynthesis protein( domain architecture ID 10192027)

polysaccharide biosynthesis protein similar to Bacillus subtilis sporulation protein YkvU, Lipid II flippase MurJ, and uncharacterized membrane protein YabM, which are involved in cell wall metabolism; belongs to the multidrug and toxic compound extrusion (MATE)-like transporter superfamily

Gene Ontology:  GO:0016020|GO:0009252
PubMed:  31866287|33774036

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SpoVB COG5841
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle ...
 8-542 8.73e-131

Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle control, cell division, chromosome partitioning];


:

Pssm-ID: 444543 [Multi-domain]  Cd Length: 532  Bit Score: 391.45  E-value: 8.73e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183   8 TQQQQMLRGTAWMTASNIISRLLGALYIIPWYAWMGkqgDQANALFGQGYNIYALFLLISTAGIPVAIAKQVSKYNTLGK 87
Cdd:COG5841    1 MKKQSFLKGALILTAAGLISKILGAIYRIPLQNIIG---DEGFGLYQMAYPIYGLFLTLATAGIPVAISKLVAEYNALGD 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183  88 METSFFLLKRILYYMIGLGLIFGVFMYFASPWMSYLSGGDEDLVRVMRSLSWAVVIFPSMSVLRGFFQGFNNMKPYALSQ 167
Cdd:COG5841   78 YKGARRIFRVSLLLLLILGLVFFLLLFFGAPFIARLLLGDPRAYYSLRALAPALLIVPVMSVLRGYFQGLQNMTPTAVSQ 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183 168 IAEQIIRVIWMLLATFFIMKIGtgdYVTAVVQSTFAAFIGMLASYGVLFFYLWKE-GKLKSLFGKQAVHPDINPTAIVIE 246
Cdd:COG5841  158 VIEQIVRVIFILLLAYLLLPYG---LEYAAAGATFGAVIGALAGLLVLLYYYRKRkKKLKRLLEKSKTKSKESSKDILKE 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183 247 TFKEAVPFIITGSAIQLFQLIDQWTFIRTMEKFTsYSNSQLQVLYAYLSSNPSKITMILIAVALSIAGVGIPLLTENMVK 326
Cdd:COG5841  235 LLRIAIPITLSSLVLPLFQLIDSFTVPRRLQAAG-LSASEATSLYGILSGMAQPLVNLPTVLATALATSLVPAISEAFAK 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183 327 KDLKGAAKLIINNLQLLLLFIVPAIVGSVILAKPLYTVFYGAPDSqAHLLFVASLiQVIFLALYSVLAPMLQAIFETRKA 406
Cdd:COG5841  314 KDRKLVRRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFGNPEG-GGILAILAP-SAIFLSLQQVTTGILQGLGKQKIP 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183 407 INYFAIGVLVKAILQLPLIIFLGALGPVISTAIGLGVPIALMYNHLHTVTHFSRKtVFRKALLICILTVLMAIPVAVFYW 486
Cdd:COG5841  392 VINLLIGLLVKIILNYLLVPLFGIYGAALATVIGYLVAAILNLAALKKYTGFKLD-LRRRLLKPLLASLIMGIVVLLLYR 470

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 739751183 487 LFQFVLsPISRMGSVIYLVIGGGLGIGVYGVLALVTRMADQ-------LLGARAASLRAKLHI 542
Cdd:COG5841  471 LLSLFL-PESRLGALLATLIAVLVGAIVYLLLLLKLGLITKeelrrlpKGGKKLARLLRKLKL 532
 
Name Accession Description Interval E-value
SpoVB COG5841
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle ...
 8-542 8.73e-131

Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444543 [Multi-domain]  Cd Length: 532  Bit Score: 391.45  E-value: 8.73e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183   8 TQQQQMLRGTAWMTASNIISRLLGALYIIPWYAWMGkqgDQANALFGQGYNIYALFLLISTAGIPVAIAKQVSKYNTLGK 87
Cdd:COG5841    1 MKKQSFLKGALILTAAGLISKILGAIYRIPLQNIIG---DEGFGLYQMAYPIYGLFLTLATAGIPVAISKLVAEYNALGD 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183  88 METSFFLLKRILYYMIGLGLIFGVFMYFASPWMSYLSGGDEDLVRVMRSLSWAVVIFPSMSVLRGFFQGFNNMKPYALSQ 167
Cdd:COG5841   78 YKGARRIFRVSLLLLLILGLVFFLLLFFGAPFIARLLLGDPRAYYSLRALAPALLIVPVMSVLRGYFQGLQNMTPTAVSQ 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183 168 IAEQIIRVIWMLLATFFIMKIGtgdYVTAVVQSTFAAFIGMLASYGVLFFYLWKE-GKLKSLFGKQAVHPDINPTAIVIE 246
Cdd:COG5841  158 VIEQIVRVIFILLLAYLLLPYG---LEYAAAGATFGAVIGALAGLLVLLYYYRKRkKKLKRLLEKSKTKSKESSKDILKE 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183 247 TFKEAVPFIITGSAIQLFQLIDQWTFIRTMEKFTsYSNSQLQVLYAYLSSNPSKITMILIAVALSIAGVGIPLLTENMVK 326
Cdd:COG5841  235 LLRIAIPITLSSLVLPLFQLIDSFTVPRRLQAAG-LSASEATSLYGILSGMAQPLVNLPTVLATALATSLVPAISEAFAK 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183 327 KDLKGAAKLIINNLQLLLLFIVPAIVGSVILAKPLYTVFYGAPDSqAHLLFVASLiQVIFLALYSVLAPMLQAIFETRKA 406
Cdd:COG5841  314 KDRKLVRRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFGNPEG-GGILAILAP-SAIFLSLQQVTTGILQGLGKQKIP 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183 407 INYFAIGVLVKAILQLPLIIFLGALGPVISTAIGLGVPIALMYNHLHTVTHFSRKtVFRKALLICILTVLMAIPVAVFYW 486
Cdd:COG5841  392 VINLLIGLLVKIILNYLLVPLFGIYGAALATVIGYLVAAILNLAALKKYTGFKLD-LRRRLLKPLLASLIMGIVVLLLYR 470

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 739751183 487 LFQFVLsPISRMGSVIYLVIGGGLGIGVYGVLALVTRMADQ-------LLGARAASLRAKLHI 542
Cdd:COG5841  471 LLSLFL-PESRLGALLATLIAVLVGAIVYLLLLLKLGLITKeelrrlpKGGKKLARLLRKLKL 532
MATE_SpoVB_like cd13124
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ...
 18-458 1.57e-116

Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).


Pssm-ID: 240529 [Multi-domain]  Cd Length: 434  Bit Score: 351.38  E-value: 1.57e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183  18 AWMTASNIISRLLGALYIIPWYAWMGkqgDQANALFGQGYNIYALFLLISTAGIPVAIAKQVSKYNTLGKMETSFFLLKR 97
Cdd:cd13124    1 LILTIAGLISKILGAIYRIPLQNIIG---DEGMGLYQMAYPIYGIFLTLATAGIPVAISKLVAEYNALGDYKGARRIFRV 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183  98 ILYYMIGLGLIFGVFMYFASPWMSYLSGGDEDLVRVMRSLSWAVVIFPSMSVLRGFFQGFNNMKPYALSQIAEQIIRVIW 177
Cdd:cd13124   78 SLILLLILGLVFFLLLFFGAPFLAQLLLGDPRLAPVIRALAPAILIVPLLSVLRGYFQGLQNMTPTAVSQVIEQIVRVIV 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183 178 MLLATFFIMKIGtGDYVTAVVQSTFAAFIGMLASYGVLFFYLWKEGKLKSLFGKQAVHPDINPTAIVIETFKEAVPFIIT 257
Cdd:cd13124  158 ILVLAYLLLPVG-GGLYYAAAGATFGAVIGALAGLLVLLYYYRKKRRELKRLLRKSPRSKISTKEILKELLSYAIPITLS 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183 258 GSAIQLFQLIDQWTFIRTMEKFTsYSNSQLQVLYAYLSSNPSKITMILIAVALSIAGVGIPLLTENMVKKDLKGAAKLII 337
Cdd:cd13124  237 SLILPLLQLIDSFTVPRRLQAAG-LSESEATALYGILTGRAQPLVQLPTVIATALSTSLVPAISEAYAKGDKKELRRRIN 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183 338 NNLQLLLLFIVPAIVGSVILAKPLYTVFYGAPDSqAHLLFVASLIqVIFLALYSVLAPMLQAIFETRKAINYFAIGVLVK 417
Cdd:cd13124  316 QALRLTLLIGLPAAVGLAVLAEPINTLLFGDSEG-GLILQILAPS-ILFLSLQQVTAAILQGLGKVKIPVINLLIGLLVK 393

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 739751183 418 AILQLPLIIFLGALGPVISTAIGLGVPIALMYNHLHTVTHF 458
Cdd:cd13124  394 IVLNYVLIPIFGIYGAAIATVIGFLVAALLNLRALKKLLGF 434
spore_V_B TIGR02900
stage V sporulation protein B; SpoVB is the stage V sporulation protein B of the bacterial ...
 14-476 5.91e-24

stage V sporulation protein B; SpoVB is the stage V sporulation protein B of the bacterial endopore formation program in Bacillus subtilis and various other Firmcutes. It is nearly universal among endospore-formers. Paralogs with rather high sequence similarity to SpoVB exist, including YkvU in B. subtilis and a number of proteins in the genus Clostridium. [Cellular processes, Sporulation and germination]


Pssm-ID: 274343 [Multi-domain]  Cd Length: 488  Bit Score: 105.07  E-value: 5.91e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183   14 LRGTAWMTASNIISRLLGALYIIPWYAWMGKQGdqaNALFGQGYNIYALFLLISTAGIPVAIAKQVSKYNTLGKMETSFF 93
Cdd:TIGR02900   2 LKGTFILTIANLITRILGFIFRIVLSRILGAEG---VGLYGMAMPIYFLFITLTTGGLPVAISKFVAEASAKNDRKNIKK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183   94 LLKRILYYMIGLGLIFGVFMYFASPWMSYLSGGDEDLVRVMRSLSWAVVIFPSMSVLRGFFQGFNNMKPYALSQIAEQII 173
Cdd:TIGR02900  79 ILKVSLIFTLIWSLIVTAIVFLLSPFIASTLLKDERSLYSLLVICPAMPFIALSSVLKGYFQGISNMKPPAYIQVIEQIV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183  174 RVIWMLLATFFIMKIGTGDYVTAVVqstFAAFIGMLASYGVLFFYLWKEGKLKSLFGKQAVHPdiNPTAIVIETFKEAVP 253
Cdd:TIGR02900 159 RISVVALLISAFLPYGLEYAVAGAY---LSLVLGELVSLLYLYFFFKRKKSFSIRFPFFDYKS--EGKALLFDLFSVSLP 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183  254 FIITGSAIQLFQLIDQWTFIRTMeKFTSYSNSQLQVLYAYLSSNPSKITMILIAVALSIAGVGIPLLTENMVKKDLKGAA 333
Cdd:TIGR02900 234 LTLSRFIGSLLYFLETLLVPQRL-VIAGVTYREATSLYGKLSGMAMPLLTFPAVITSSLSTALVPDISEAMAKKNYSSIE 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183  334 KLIINNLQLLLLFIVPAIVGSVILAKPLYTVFYGAPDSQAHLLFVAslIQVIFLALYSVLAPMLQAIFETRKAINYFAIG 413
Cdd:TIGR02900 313 KRINQAIKISLLLGLITTVILLVIPDELGALFYGRPDAGNFIRVLA--PSFPFLYFSAPLQSILQGLGKQKVALRNSLIG 390

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 739751183  414 VLVKAILQLPL--IIFLGALGPVISTAIGLGVPIALMYNHLHTVTHFSRKTVFRKA-LLICILTVL 476
Cdd:TIGR02900 391 AIVKIILLFVLtsIPSINIYGYAITFIITSVLVTILNLAEIKKNIRITIDLSDFLIfALLGILVYL 456
Polysacc_synt pfam01943
Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. ...
 14-269 5.93e-17

Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. Many members of the family are implicated in production of polysaccharide. The family includes RfbX part of the O antigen biosynthesis operon. The family includes SpoVB from Bacillus subtilis, which is involved in spore cortex biosynthesis.


Pssm-ID: 426523 [Multi-domain]  Cd Length: 274  Bit Score: 81.19  E-value: 5.93e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183   14 LRGTAWMTASNIISRLLGALYIIPWYAWMGKQGdqaNALFGQGYNIYALFLLISTAGIPVAIAKQVSKYNTLGKMETSFF 93
Cdd:pfam01943   2 LKNVIVLLLSQLITYLLAFVTLPYLARILGPEG---FGLYAFALAFVGLLTIFTDFGFNAALVREIAKYREKYELVSLYW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183   94 LlkrilyyMIGLGLIFGVFMYFASPWMSYLSGGDEDLVRVMRSLSWAVVIFPSMSVLRGFFQGFNNMKPYALSQIAEQII 173
Cdd:pfam01943  79 L-------NALLVKLVLVLLFLLLPLIAAFLGLPELAVLYRILALMFLLLPGVVQFRRGLFQGLERMKYALISQIVESLS 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183  174 RVIWMLLATFfimkiGTGDYVTAVVQSTFAAFIGMLASYGVLFFYLWKEGKLKSLfgkqavhpdinptAIVIETFKEAVP 253
Cdd:pfam01943 152 RVILVFIAVF-----LPGDIVAALLYQVLAALVGGIIALAVLRKIFRPRFVFPSL-------------KLVRKLLSFGAP 213

                         250
                  ....*....|....*.
gi 739751183  254 FIITGSAIQLFQLIDQ 269
Cdd:pfam01943 214 LFISSLAISLYTYIDS 229
 
Name Accession Description Interval E-value
SpoVB COG5841
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle ...
 8-542 8.73e-131

Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444543 [Multi-domain]  Cd Length: 532  Bit Score: 391.45  E-value: 8.73e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183   8 TQQQQMLRGTAWMTASNIISRLLGALYIIPWYAWMGkqgDQANALFGQGYNIYALFLLISTAGIPVAIAKQVSKYNTLGK 87
Cdd:COG5841    1 MKKQSFLKGALILTAAGLISKILGAIYRIPLQNIIG---DEGFGLYQMAYPIYGLFLTLATAGIPVAISKLVAEYNALGD 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183  88 METSFFLLKRILYYMIGLGLIFGVFMYFASPWMSYLSGGDEDLVRVMRSLSWAVVIFPSMSVLRGFFQGFNNMKPYALSQ 167
Cdd:COG5841   78 YKGARRIFRVSLLLLLILGLVFFLLLFFGAPFIARLLLGDPRAYYSLRALAPALLIVPVMSVLRGYFQGLQNMTPTAVSQ 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183 168 IAEQIIRVIWMLLATFFIMKIGtgdYVTAVVQSTFAAFIGMLASYGVLFFYLWKE-GKLKSLFGKQAVHPDINPTAIVIE 246
Cdd:COG5841  158 VIEQIVRVIFILLLAYLLLPYG---LEYAAAGATFGAVIGALAGLLVLLYYYRKRkKKLKRLLEKSKTKSKESSKDILKE 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183 247 TFKEAVPFIITGSAIQLFQLIDQWTFIRTMEKFTsYSNSQLQVLYAYLSSNPSKITMILIAVALSIAGVGIPLLTENMVK 326
Cdd:COG5841  235 LLRIAIPITLSSLVLPLFQLIDSFTVPRRLQAAG-LSASEATSLYGILSGMAQPLVNLPTVLATALATSLVPAISEAFAK 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183 327 KDLKGAAKLIINNLQLLLLFIVPAIVGSVILAKPLYTVFYGAPDSqAHLLFVASLiQVIFLALYSVLAPMLQAIFETRKA 406
Cdd:COG5841  314 KDRKLVRRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFGNPEG-GGILAILAP-SAIFLSLQQVTTGILQGLGKQKIP 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183 407 INYFAIGVLVKAILQLPLIIFLGALGPVISTAIGLGVPIALMYNHLHTVTHFSRKtVFRKALLICILTVLMAIPVAVFYW 486
Cdd:COG5841  392 VINLLIGLLVKIILNYLLVPLFGIYGAALATVIGYLVAAILNLAALKKYTGFKLD-LRRRLLKPLLASLIMGIVVLLLYR 470

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 739751183 487 LFQFVLsPISRMGSVIYLVIGGGLGIGVYGVLALVTRMADQ-------LLGARAASLRAKLHI 542
Cdd:COG5841  471 LLSLFL-PESRLGALLATLIAVLVGAIVYLLLLLKLGLITKeelrrlpKGGKKLARLLRKLKL 532
MATE_SpoVB_like cd13124
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ...
 18-458 1.57e-116

Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).


Pssm-ID: 240529 [Multi-domain]  Cd Length: 434  Bit Score: 351.38  E-value: 1.57e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183  18 AWMTASNIISRLLGALYIIPWYAWMGkqgDQANALFGQGYNIYALFLLISTAGIPVAIAKQVSKYNTLGKMETSFFLLKR 97
Cdd:cd13124    1 LILTIAGLISKILGAIYRIPLQNIIG---DEGMGLYQMAYPIYGIFLTLATAGIPVAISKLVAEYNALGDYKGARRIFRV 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183  98 ILYYMIGLGLIFGVFMYFASPWMSYLSGGDEDLVRVMRSLSWAVVIFPSMSVLRGFFQGFNNMKPYALSQIAEQIIRVIW 177
Cdd:cd13124   78 SLILLLILGLVFFLLLFFGAPFLAQLLLGDPRLAPVIRALAPAILIVPLLSVLRGYFQGLQNMTPTAVSQVIEQIVRVIV 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183 178 MLLATFFIMKIGtGDYVTAVVQSTFAAFIGMLASYGVLFFYLWKEGKLKSLFGKQAVHPDINPTAIVIETFKEAVPFIIT 257
Cdd:cd13124  158 ILVLAYLLLPVG-GGLYYAAAGATFGAVIGALAGLLVLLYYYRKKRRELKRLLRKSPRSKISTKEILKELLSYAIPITLS 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183 258 GSAIQLFQLIDQWTFIRTMEKFTsYSNSQLQVLYAYLSSNPSKITMILIAVALSIAGVGIPLLTENMVKKDLKGAAKLII 337
Cdd:cd13124  237 SLILPLLQLIDSFTVPRRLQAAG-LSESEATALYGILTGRAQPLVQLPTVIATALSTSLVPAISEAYAKGDKKELRRRIN 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183 338 NNLQLLLLFIVPAIVGSVILAKPLYTVFYGAPDSqAHLLFVASLIqVIFLALYSVLAPMLQAIFETRKAINYFAIGVLVK 417
Cdd:cd13124  316 QALRLTLLIGLPAAVGLAVLAEPINTLLFGDSEG-GLILQILAPS-ILFLSLQQVTAAILQGLGKVKIPVINLLIGLLVK 393

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 739751183 418 AILQLPLIIFLGALGPVISTAIGLGVPIALMYNHLHTVTHF 458
Cdd:cd13124  394 IVLNYVLIPIFGIYGAAIATVIGFLVAALLNLRALKKLLGF 434
spore_V_B TIGR02900
stage V sporulation protein B; SpoVB is the stage V sporulation protein B of the bacterial ...
 14-476 5.91e-24

stage V sporulation protein B; SpoVB is the stage V sporulation protein B of the bacterial endopore formation program in Bacillus subtilis and various other Firmcutes. It is nearly universal among endospore-formers. Paralogs with rather high sequence similarity to SpoVB exist, including YkvU in B. subtilis and a number of proteins in the genus Clostridium. [Cellular processes, Sporulation and germination]


Pssm-ID: 274343 [Multi-domain]  Cd Length: 488  Bit Score: 105.07  E-value: 5.91e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183   14 LRGTAWMTASNIISRLLGALYIIPWYAWMGKQGdqaNALFGQGYNIYALFLLISTAGIPVAIAKQVSKYNTLGKMETSFF 93
Cdd:TIGR02900   2 LKGTFILTIANLITRILGFIFRIVLSRILGAEG---VGLYGMAMPIYFLFITLTTGGLPVAISKFVAEASAKNDRKNIKK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183   94 LLKRILYYMIGLGLIFGVFMYFASPWMSYLSGGDEDLVRVMRSLSWAVVIFPSMSVLRGFFQGFNNMKPYALSQIAEQII 173
Cdd:TIGR02900  79 ILKVSLIFTLIWSLIVTAIVFLLSPFIASTLLKDERSLYSLLVICPAMPFIALSSVLKGYFQGISNMKPPAYIQVIEQIV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183  174 RVIWMLLATFFIMKIGTGDYVTAVVqstFAAFIGMLASYGVLFFYLWKEGKLKSLFGKQAVHPdiNPTAIVIETFKEAVP 253
Cdd:TIGR02900 159 RISVVALLISAFLPYGLEYAVAGAY---LSLVLGELVSLLYLYFFFKRKKSFSIRFPFFDYKS--EGKALLFDLFSVSLP 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183  254 FIITGSAIQLFQLIDQWTFIRTMeKFTSYSNSQLQVLYAYLSSNPSKITMILIAVALSIAGVGIPLLTENMVKKDLKGAA 333
Cdd:TIGR02900 234 LTLSRFIGSLLYFLETLLVPQRL-VIAGVTYREATSLYGKLSGMAMPLLTFPAVITSSLSTALVPDISEAMAKKNYSSIE 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183  334 KLIINNLQLLLLFIVPAIVGSVILAKPLYTVFYGAPDSQAHLLFVAslIQVIFLALYSVLAPMLQAIFETRKAINYFAIG 413
Cdd:TIGR02900 313 KRINQAIKISLLLGLITTVILLVIPDELGALFYGRPDAGNFIRVLA--PSFPFLYFSAPLQSILQGLGKQKVALRNSLIG 390

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 739751183  414 VLVKAILQLPL--IIFLGALGPVISTAIGLGVPIALMYNHLHTVTHFSRKTVFRKA-LLICILTVL 476
Cdd:TIGR02900 391 AIVKIILLFVLtsIPSINIYGYAITFIITSVLVTILNLAEIKKNIRITIDLSDFLIfALLGILVYL 456
MATE_Wzx_like cd13128
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ...
 13-449 2.84e-22

Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).


Pssm-ID: 240533 [Multi-domain]  Cd Length: 402  Bit Score: 99.15  E-value: 2.84e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183  13 MLRGTAWMTASNIISRLLGALYIIpwyaWMGKQ-GDQANALFGQGYNIYALFLLISTAGIPVAIAKQVSKYNtlgKMETS 91
Cdd:cd13128    1 LAKNSGWLFVGNIISKLLGFLVRV----YLARYlGPEGFGILSLALAFVGLFSIFADLGLPTALVREIARYR---KEKIR 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183  92 FFLLKrILYYMIGLGLIFGVFMYFASPWmsyLSGGDEDLVRVMRSLSWAVVIFPSMSVLRGFFQGFNNMKPYALSQIAEQ 171
Cdd:cd13128   74 EIIST-SLVLKLILGILALLLLFLFAFL---IAFYDPELVLLLYILALSLPFSALNSLFRGIFQGFEKMKYIVIARIIES 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183 172 IIrviwMLLATFFIMKIGTGDYVTAvvqstFAAFIGMLASYGVLFFYLWKEGKLKSLFgkqavhpdINPTAIVIETFKEA 251
Cdd:cd13128  150 VL----SLILALILVLLGGGLIGFA-----LAYLIASVLSAILLLYIYRKKILLPKFF--------SFDLKLAKELLRFS 212

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183 252 VPFIITGSAIQLFQLIDQW--TFIRTMEKFTSYsnsqlqvlyaylsSNPSKITMILIAVALSIAGVGIPLLTENMvKKDL 329
Cdd:cd13128  213 IPLALSGIFSLIYTRIDTImlGYFLGDAAVGIY-------------NAAYRIAELLLFIPSAISTALFPRISELY-KNDK 278

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183 330 KGAAKLIINNLQLLLLFIVPAIVGSVILAKPLYTVFYGAPDSQAHLLFVASLIQVIFLALYSVLAPMLQAIFETRKAINY 409
Cdd:cd13128  279 DELKKLLKKSFKYLFLISLPIAIGLFLFAEPIITLLFGEEYLPAALVLQILAWGFLFIFLNGIFGSILQAIGKQKLTLKI 358

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 739751183 410 FAIGVLVKAILQLPLIIFLGALGPVISTAIGLGVPIALMY 449
Cdd:cd13128  359 LLIGALLNVILNLLLIPKYGIIGAAIATLISEFIIFILLL 398
Polysacc_synt pfam01943
Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. ...
 14-269 5.93e-17

Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. Many members of the family are implicated in production of polysaccharide. The family includes RfbX part of the O antigen biosynthesis operon. The family includes SpoVB from Bacillus subtilis, which is involved in spore cortex biosynthesis.


Pssm-ID: 426523 [Multi-domain]  Cd Length: 274  Bit Score: 81.19  E-value: 5.93e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183   14 LRGTAWMTASNIISRLLGALYIIPWYAWMGKQGdqaNALFGQGYNIYALFLLISTAGIPVAIAKQVSKYNTLGKMETSFF 93
Cdd:pfam01943   2 LKNVIVLLLSQLITYLLAFVTLPYLARILGPEG---FGLYAFALAFVGLLTIFTDFGFNAALVREIAKYREKYELVSLYW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183   94 LlkrilyyMIGLGLIFGVFMYFASPWMSYLSGGDEDLVRVMRSLSWAVVIFPSMSVLRGFFQGFNNMKPYALSQIAEQII 173
Cdd:pfam01943  79 L-------NALLVKLVLVLLFLLLPLIAAFLGLPELAVLYRILALMFLLLPGVVQFRRGLFQGLERMKYALISQIVESLS 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183  174 RVIWMLLATFfimkiGTGDYVTAVVQSTFAAFIGMLASYGVLFFYLWKEGKLKSLfgkqavhpdinptAIVIETFKEAVP 253
Cdd:pfam01943 152 RVILVFIAVF-----LPGDIVAALLYQVLAALVGGIIALAVLRKIFRPRFVFPSL-------------KLVRKLLSFGAP 213

                         250
                  ....*....|....*.
gi 739751183  254 FIITGSAIQLFQLIDQ 269
Cdd:pfam01943 214 LFISSLAISLYTYIDS 229
RfbX COG2244
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ...
 11-449 1.51e-15

Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441845 [Multi-domain]  Cd Length: 366  Bit Score: 78.45  E-value: 1.51e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183  11 QQMLRGTAWMTASNIISRLLGALyIIPWYAWMGkqGDQANALFGQGYNIYALFLLISTAGIPVAIAKQVSKYNTLGKMEt 90
Cdd:COG2244    2 KKLLKNTLWLLLGQLLGALLGFL-LLPLLARLL--GPEEYGLFALALSIVALLSVLADLGLSTALVRFIAEYREEELRR- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183  91 sffLLKRILYYMIGLGLIFGVFMYFASPWMSYLSGgDEDLVRVMRSLSWAVVIFPSMSVLRGFFQGFNNMKPYALSQIAE 170
Cdd:COG2244   78 ---LLSTALLLRLLLSLLLALLLLLLAPFIAALLG-EPELALLLLLLALALLLSALSAVLLALLRGLERFKLLALINILS 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183 171 QIIRVIWMLLATFFimkigtGDYVTAVVqstfaafigmlasygvlffylwkegklkslfgkqavhpdinptaivietFKE 250
Cdd:COG2244  154 SLLSLLLALLLALL------GLGLWGLV-------------------------------------------------LKY 178

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183 251 AVPFIITGSAIQLFQLIDQW--TFIRTMEKFTSYSNSQlqvlyaylssnpsKITMILIAVALSIAGVGIPLLTENMVKKD 328
Cdd:COG2244  179 SLPLLLSGLLGLLLTNLDRLllGALLGPAAVGIYSAAY-------------RLASLLLLLITALSQVLFPRLSRLLAEGD 245

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183 329 LKGAAKLIINNLQLLLLFIVPAIVGSVILAKPLYTVFYGAPDSQAHLLFVASLIQVIFLALYSVLAPMLQAIFETRKAIN 408
Cdd:COG2244  246 REELRRLYRKALRLLLLLGLPLALGLALLAPPLLSLLFGPEYAEAAPVLPILALGALFLALSGVLSNLLLALGRTRLLLI 325

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 739751183 409 YFAIGVLVKAILQLPLIIFLGALGPVISTAIGLGVPIALMY 449
Cdd:COG2244  326 ISLIGAVLNLVLNLLLIPRYGLVGAAIATLLSYLVLLLLLL 366
MurJ COG0728
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ...
 14-524 1.03e-14

Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440492 [Multi-domain]  Cd Length: 503  Bit Score: 76.73  E-value: 1.03e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183  14 LRGTAWMTASNIISRLLGAL--YIIpwyAWMGKQGDQANAlFGQGYNI----YALFL--LISTAGIPVaiakqVSKYNTL 85
Cdd:COG0728    1 LRAALIVAIGTLLSRILGFVrdILI---AAAFGAGAVADA-FFVAFRIpnllRRLFAegALSAAFVPV-----LAEALEK 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183  86 GKMETSFFLLKRILYYMIGLGLIFGVFMYFASPWMSYLSGGDEDLVRVMRSLSWAVVIFPSM------SVLRGFFQGFNN 159
Cdd:COG0728   72 EGEEEARRFASRVLTLLLLVLLVLTLLGILFAPLLVKLLAPGFDPEKFALAVALTRIMFPYIlfiglsALLGGVLNARGR 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183 160 MKPYALSQIaeqIIRVIWMLLATFFIMKIGTGDYVTAVvqstfAAFIGMLASYGVLFFYLWKEG-KLKSLFGKQavHPDi 238
Cdd:COG0728  152 FAAPALAPV---LLNLVIIAGLLLLAPLFGPGIYALAW-----GVLLGGVLQLLIQLPALRRLGlRLRPRFDLR--DPG- 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183 239 nptaiVIETFKEAVPFIITGSAIQLFQLIDQWtfirtmekFTSY----SNSQLQvlYAYLssnpskITMILIAV-ALSIA 313
Cdd:COG0728  221 -----VRRVLKLMLPALLGVSVSQINLLVDTI--------LASFlpegSVSALY--YADR------LYQLPLGLfGVAIG 279

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183 314 GVGIPLLTENMVKKDLKGAAKLIINNLQLLLLFIVPAIVGSVILAKPLYTVFY--GAPDSQAHLL----FVASLIQVIFL 387
Cdd:COG0728  280 TALLPRLSRAAAAGDLEEFRRTLSRGLRLVLLLTLPAAVGLIVLAEPIVRLLFerGAFTAEDTALtalaLAAYALGLPAF 359

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183 388 ALYSVLAPMLQAIFETRKAINYFAIGVLVKAILQLPLIIFLGALGPVISTAIGLGVPIALMYNHLHT-VTHFSRKTVFRK 466
Cdd:COG0728  360 ALVKVLARAFYARQDTRTPVRIAVIAVVVNIVLNLLLVPPLGHAGLALATSLSALVNALLLLVLLRRrLGGLPLRGILRT 439

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 739751183 467 ALLICILTVLMAIPVAVFYWLFQFVLSPiSRMGSVIYLVIGGGLGIGVYGVLALVTRM 524
Cdd:COG0728  440 LLKLLLASLVMGAVLWLLLRLLGDWLGG-GLLGRLLALALLILVGAAVYFALLLLLGV 496
Polysacc_synt_C pfam14667
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral ...
 376-502 1.16e-13

Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral membrane region of polysaccharide biosynthesis proteins.


Pssm-ID: 434111 [Multi-domain]  Cd Length: 141  Bit Score: 68.37  E-value: 1.16e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183  376 LFVASLIQVIFLALYSVLAPMLQAIFETRKAINYFAIGVLVKAILQLPLIIFLGALGPVISTAIGLGVPIALMYNHLHTV 455
Cdd:pfam14667   1 VLQILALSIIFLSLSTVLTSILQGLGRTKLALIALLIGALVKLILNLLLIPLFGIVGAAIATVISLLVVALLNLYYLRRY 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 739751183  456 THFSRKtvFRKALLICILTVLMAIPVAVFYWLFQFVLSPISRMGSVI 502
Cdd:pfam14667  81 LGLRLL--LRRLLKPLLAALVMGIVVYLLLLLLGLLLGLALALLLAV 125
MATE_MurJ_like cd13123
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ...
 97-449 7.44e-11

MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).


Pssm-ID: 240528 [Multi-domain]  Cd Length: 420  Bit Score: 64.01  E-value: 7.44e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183  97 RILYYMIGLGLIFGVFMYFASPWMSYL--SGGDEDLVRVMRSLswAVVIFPSM------SVLRGFFQGFNNMKPYALSQI 168
Cdd:cd13123   76 RVLTLLLLVLLLLTLLGILFAPLLVKLlaPGFSGDKFELAVAL--TRIMFPYLlfislsALLGGILNAHGRFFAPALAPV 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183 169 aeqIIRVIWMLLATFFIMKIGTGDYVTAVvqstfAAFIGMLASYGVLFFYLWKEGkLKSLFGKQAVHPDinptaiVIETF 248
Cdd:cd13123  154 ---LLNLVIIAGLLLLAPLFDLGIYALAW-----GVLLGGVLQLLVQLPALRRLG-FRFRPRLDFRDPG------VRRVL 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183 249 KEAVPFIITGSAIQLFQLIDQWtfirtmekFTSY----SNSQLQvlYAYlssnpsKITMILIAV-ALSIAGVGIPLLTEN 323
Cdd:cd13123  219 KLMLPALLGVSVSQINLLVDTI--------LASFlpegSISALY--YAD------RLYQLPLGIfGVAIATALLPRLSRL 282

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183 324 MVKKDLKGAAKLIINNLQLLLLFIVPAIVGSVILAKPLYTVFY--GAPDSQAHLL----FVASLIQVIFLALYSVLAPML 397
Cdd:cd13123  283 AAAGDLDEFRRTLSRGLRLVLFLLLPAAVGLIVLAEPIVRLLFerGAFTAEDTLMtasaLAAYALGLPAFALVKLLSRAF 362

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 739751183 398 QAIFETRKAINYFAIGVLVKAILQLPLIIFLGALGPVISTAIGLGVPIALMY 449
Cdd:cd13123  363 YALKDTKTPVKIAVIAVAVNILLNLLLIKPLGHVGLALATSLSAWVNALLLL 414
MATE_like cd12082
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ...
 22-432 8.42e-11

Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240527 [Multi-domain]  Cd Length: 420  Bit Score: 63.88  E-value: 8.42e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183  22 ASNIISRLLGALYIIPWYAWMGKQGDQANALFGQGYNIYALfLLISTAGIPVAIAKQVSKYNTLGKMETSFFLLKRILYY 101
Cdd:cd12082    2 APLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIAL-LIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183 102 MIGLGLIFGVFMYFASPWMSYLSGGDEDLVRV----MRSLSWAVVIFPSMSVLRGFFQGFNNMKPYALSQIAEQIIRviw 177
Cdd:cd12082   81 AILLGLLLAALLLFFSPLILSLLGAEEEVIELaatyLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLN--- 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183 178 MLLATFFIMkiGTGDYVTAVVQSTFAAFIGMLASyGVLFFYLWKEGKLKSLFGKQAVHPDINptaIVIETFKEAVPFIIT 257
Cdd:cd12082  158 ILLDPLLIF--GLGPPELGIAGAALATVISYVIG-ALLLLIYLRKGKKILKFKLSLLKPDLE---LLRRLLRIGLPSAIQ 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183 258 GSAIQLFQLIDQWTfirTMEKFTSYSNSQLQVLyaylssnpSKITMILIAVALSIAGVGIPLLTENMVKKDLKGAAKLII 337
Cdd:cd12082  232 NSLLSLGLLIIVAI---VAAFGGAAALAAYTVA--------FRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITW 300

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183 338 NNLQLLLLFIVPAIVGSVILAKPLYTVFYGAPDSQ--AHLLFVASLIQVIFLALYSVLAPMLQAIFETRKAinyFAIGVL 415
Cdd:cd12082  301 VALLIGLLIGAVLGLLILLFPEPILSLFTNDPEFLelAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKS---LIVSLL 377

                        410
                 ....*....|....*..
gi 739751183 416 VKAILQLPLIIFLGALG 432
Cdd:cd12082  378 SYWVVRLPLAYVLAYLG 394
NorM COG0534
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
25-432 1.74e-05

Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];


Pssm-ID: 440300 [Multi-domain]  Cd Length: 427  Bit Score: 47.45  E-value: 1.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183  25 IISRLLGALYIIPWYAWMGKQGDQANALFGQGYNIYALFLLISTaGIPVAIAKQVSKYNTLGKMETSFFLLKRILYYMIG 104
Cdd:COG0534   18 ILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLLIALGI-GLGVGGTALVAQALGAGDREEARRVLGQALLLALL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183 105 LGLIFGVFMYFASPWMSYLSGGDEDLVRV----MRSLSWAVVIFPSMSVLRGFFQGFNNMKPYALSQIAEQIIRVIwmlL 180
Cdd:COG0534   97 LGLLLTLLGLLFAPPLLRLLGADPEVLALardyLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLIGNVLNIV---L 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183 181 ATFFIMKIGTGdyvtaVVQSTFAAFIGMLASYGVLFFYLWKeGKLKSLFGKQAVHPDInptAIVIETFKEAVPFIITGSA 260
Cdd:COG0534  174 DPLLIFGGGLG-----VAGAALATVISQAVSALLLLYYLFR-KRSLLRLRLRDLRPDR---KILKRILRIGLPAGLQQLA 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183 261 IQLFQLIdqwtFIRTMEKFTSYSNSQLQVLyaylssnpSKITMILIAVALSIAGVGIPLLTENMVKKDLKGAAKLIINNL 340
Cdd:COG0534  245 ESLGFLV----LNALVARLGTAAVAAYGIA--------LRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLAL 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183 341 QLLLLFIVPAIVGSVILAKPLYTVFYGAPDSQA---HLLFVASLIQvIFLALYSVLAPMLQAIFETRKAinyFAIGVLVK 417
Cdd:COG0534  313 LLALGIGLLLALLLFLFPEPIIGLFTDDPEVIAlaaTYLRIAALFQ-PFDGLQFVLSGALRGAGDTRFP---MIISLLRL 388

                        410
                 ....*....|....*
gi 739751183 418 AILQLPLIIFLGALG 432
Cdd:COG0534  389 WLVRLPLAYLLAFLG 403
MATE_like_10 cd13125
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ...
 51-219 6.66e-03

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides, such as O-antigen. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240530 [Multi-domain]  Cd Length: 409  Bit Score: 39.06  E-value: 6.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183  51 ALFGQGYNIYALFLLISTAGIPVAIAKQVSKYNTLGKMETSFFLLKRILYymIGLGLIFGVFMYFASPWMSYLSGGDEDL 130
Cdd:cd13125   34 ALLGQLQNFVTILQTIAGGGINNGVVKYTAEYKDDEEKLARVWSTAFRIT--LILSILGGLLLLLFSKPLSSLLFGDIDY 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739751183 131 VRVMRSLSWAVVIFPSMSVLRGFFQGFNNMKPYALSQIAEQIIRVIWMLLATFFIMKIGTgdYVTAVVQSTFAAFIGMLA 210
Cdd:cd13125  112 SWVFILLGLALPLFALNNLLLAILNGLKEIKRYALINIISSLIGLLVSVLLVYFYGLKGA--LLALVLNQSLIFLVTLIY 189


                 ....*....
gi 739751183 211 SYGVLFFYL 219
Cdd:cd13125  190 SRKQPWFKL 198
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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