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Conserved domains on  [gi|73912720|ref|NP_001027535|]
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MICOS complex subunit MIC10 isoform a [Homo sapiens]

Protein Classification

MICOS complex subunit MIC10( domain architecture ID 10516689)

MICOS complex subunit MIC10 is a component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane

Gene Ontology:  GO:0061617|GO:0005743|GO:0007007|GO:0042407
TCDB:  8.A.156

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF543 pfam04418
Domain of unknown function (DUF543); This family of short eukaryotic proteins has no known ...
 1-62 3.55e-26

Domain of unknown function (DUF543); This family of short eukaryotic proteins has no known function. Most of the members of this family are only 80 amino acid residues long. However the Arabidopsis homolog is over 300 residues long. The presumed domain contains a conserved amino terminal cysteine and a conserved motif GXGXGXG in the carboxy terminal half that may be functionally important.


:

Pssm-ID: 461300  Cd Length: 75  Bit Score: 91.20  E-value: 3.55e-26
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 73912720    1 MSESELGRKWDRCLADAVVKIGTGFGLGIVFSLTFFKRRMWPLAFGSGMGLGMAYSNCQHDF 62
Cdd:pfam04418 13 SSESLLNEKWDVCLSNFLVKTGLGFGVGVVASVLLFRRRAAPVWLGAGFGLGRAYAECDAIF 74
 
Name Accession Description Interval E-value
DUF543 pfam04418
Domain of unknown function (DUF543); This family of short eukaryotic proteins has no known ...
 1-62 3.55e-26

Domain of unknown function (DUF543); This family of short eukaryotic proteins has no known function. Most of the members of this family are only 80 amino acid residues long. However the Arabidopsis homolog is over 300 residues long. The presumed domain contains a conserved amino terminal cysteine and a conserved motif GXGXGXG in the carboxy terminal half that may be functionally important.


Pssm-ID: 461300  Cd Length: 75  Bit Score: 91.20  E-value: 3.55e-26
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 73912720    1 MSESELGRKWDRCLADAVVKIGTGFGLGIVFSLTFFKRRMWPLAFGSGMGLGMAYSNCQHDF 62
Cdd:pfam04418 13 SSESLLNEKWDVCLSNFLVKTGLGFGVGVVASVLLFRRRAAPVWLGAGFGLGRAYAECDAIF 74
 
Name Accession Description Interval E-value
DUF543 pfam04418
Domain of unknown function (DUF543); This family of short eukaryotic proteins has no known ...
 1-62 3.55e-26

Domain of unknown function (DUF543); This family of short eukaryotic proteins has no known function. Most of the members of this family are only 80 amino acid residues long. However the Arabidopsis homolog is over 300 residues long. The presumed domain contains a conserved amino terminal cysteine and a conserved motif GXGXGXG in the carboxy terminal half that may be functionally important.


Pssm-ID: 461300  Cd Length: 75  Bit Score: 91.20  E-value: 3.55e-26
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 73912720    1 MSESELGRKWDRCLADAVVKIGTGFGLGIVFSLTFFKRRMWPLAFGSGMGLGMAYSNCQHDF 62
Cdd:pfam04418 13 SSESLLNEKWDVCLSNFLVKTGLGFGVGVVASVLLFRRRAAPVWLGAGFGLGRAYAECDAIF 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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