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Conserved domains on  [gi|738803076|ref|WP_036694124|]
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MULTISPECIES: helix-turn-helix domain-containing protein [unclassified Paenibacillus]

Protein Classification

winged helix-turn-helix transcriptional regulator( domain architecture ID 10004391)

winged helix-turn-helix (HTH) transcriptional regulator containing a HxlR family HTH domain; similar to HTH-type transcriptional regulator HxlR, a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|10679470|10908318

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
5-103 1.64e-40

DNA-binding transcriptional regulator, HxlR family [Transcription];


:

Pssm-ID: 441339  Cd Length: 108  Bit Score: 129.60  E-value: 1.64e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738803076   5 EMCPrFEKAVDVLSKRWVALIVFVLMDGPRRFGEIEHCLSNLSGKVLSDRLKEMEAEGIIQRSVYPEMPVRIEYSLTDKG 84
Cdd:COG1733    8 ADCP-VRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYSLTEKG 86

                         90
                 ....*....|....*....
gi 738803076  85 TALAPILGEIGNWSTDWIE 103
Cdd:COG1733   87 RSLLPVLDALAEWGEEHLP 105
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
5-103 1.64e-40

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 129.60  E-value: 1.64e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738803076   5 EMCPrFEKAVDVLSKRWVALIVFVLMDGPRRFGEIEHCLSNLSGKVLSDRLKEMEAEGIIQRSVYPEMPVRIEYSLTDKG 84
Cdd:COG1733    8 ADCP-VRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYSLTEKG 86

                         90
                 ....*....|....*....
gi 738803076  85 TALAPILGEIGNWSTDWIE 103
Cdd:COG1733   87 RSLLPVLDALAEWGEEHLP 105
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 16-103 4.67e-37

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 120.48  E-value: 4.67e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738803076   16 VLSKRWVALIVFVLMDGPRRFGEIEHCLSNLSGKVLSDRLKEMEAEGIIQRSVYPEMPVRIEYSLTDKGTALAPILGEIG 95
Cdd:pfam01638   1 LIGGKWKGLILRELLDGKKRFSELKRAIPGITQKMLTQRLRELEQDGIINREVYPEVPPKVEYSLTEKGRSLEPILQELC 80


                  ....*...
gi 738803076   96 NWSTDWIE 103
Cdd:pfam01638  81 DWGEEYLE 88
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 15-90 8.90e-06

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 40.36  E-value: 8.90e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 738803076  15 DVLSKRWVALIVFVLMDGPRRFGEIEHCLsNLSGKVLSDRLKEMEAEGIIQRSvypEMPVRIEYSLTDKGTALAPI 90
Cdd:cd00090    2 KALSDPTRLRILRLLLEGPLTVSELAERL-GLSQSTVSRHLKKLEEAGLVESR---REGRRVYYSLTDAERLLALL 73
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
5-103 1.64e-40

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 129.60  E-value: 1.64e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738803076   5 EMCPrFEKAVDVLSKRWVALIVFVLMDGPRRFGEIEHCLSNLSGKVLSDRLKEMEAEGIIQRSVYPEMPVRIEYSLTDKG 84
Cdd:COG1733    8 ADCP-VRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYSLTEKG 86

                         90
                 ....*....|....*....
gi 738803076  85 TALAPILGEIGNWSTDWIE 103
Cdd:COG1733   87 RSLLPVLDALAEWGEEHLP 105
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 16-103 4.67e-37

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 120.48  E-value: 4.67e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738803076   16 VLSKRWVALIVFVLMDGPRRFGEIEHCLSNLSGKVLSDRLKEMEAEGIIQRSVYPEMPVRIEYSLTDKGTALAPILGEIG 95
Cdd:pfam01638   1 LIGGKWKGLILRELLDGKKRFSELKRAIPGITQKMLTQRLRELEQDGIINREVYPEVPPKVEYSLTEKGRSLEPILQELC 80


                  ....*...
gi 738803076   96 NWSTDWIE 103
Cdd:pfam01638  81 DWGEEYLE 88
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 15-90 8.90e-06

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 40.36  E-value: 8.90e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 738803076  15 DVLSKRWVALIVFVLMDGPRRFGEIEHCLsNLSGKVLSDRLKEMEAEGIIQRSvypEMPVRIEYSLTDKGTALAPI 90
Cdd:cd00090    2 KALSDPTRLRILRLLLEGPLTVSELAERL-GLSQSTVSRHLKKLEEAGLVESR---REGRRVYYSLTDAERLLALL 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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