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Conserved domains on  [gi|736648571|ref|WP_034655977|]
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VOC family protein [Cellulosimicrobium sp. MM]

Protein Classification

VOC family protein( domain architecture ID 10001243)

vicinal oxygen chelate (VOC) family protein uses a metal center to coordinate a substrate, intermediate, or transition state through vicinal oxygen atoms

CATH:  3.10.180.10
Gene Ontology:  GO:0046872|GO:0003824
PubMed:  21820381|11076500

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GloA COG0346
Catechol 2,3-dioxygenase or related enzyme, vicinal oxygen chelate (VOC) family [Secondary ...
 8-125 7.19e-15

Catechol 2,3-dioxygenase or related enzyme, vicinal oxygen chelate (VOC) family [Secondary metabolites biosynthesis, transport and catabolism];


:

Pssm-ID: 440115 [Multi-domain]  Cd Length: 125  Bit Score: 65.78  E-value: 7.19e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736648571   8 GFSVDDVDAARRFYADDLGLTVSGD--------DMLWLEIGGGARVLVYPKGE---AHAPASFTVLNFPVADVPGTVAAL 76
Cdd:COG0346    7 TLRVSDLEASLAFYTDVLGLELVKRtdfgdggfGHAFLRLGDGTELELFEAPGaapAPGGGGLHHLAFRVDDLDAAYARL 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 736648571  77 RERGVAFERYAGTpvetdddfvfRGGGPLIAWFTDPAGNVLSIIQDDDA 125
Cdd:COG0346   87 RAAGVEIEGEPRD----------RAYGYRSAYFRDPDGNLIELVEPPPG 125
 
Name Accession Description Interval E-value
GloA COG0346
Catechol 2,3-dioxygenase or related enzyme, vicinal oxygen chelate (VOC) family [Secondary ...
 8-125 7.19e-15

Catechol 2,3-dioxygenase or related enzyme, vicinal oxygen chelate (VOC) family [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440115 [Multi-domain]  Cd Length: 125  Bit Score: 65.78  E-value: 7.19e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736648571   8 GFSVDDVDAARRFYADDLGLTVSGD--------DMLWLEIGGGARVLVYPKGE---AHAPASFTVLNFPVADVPGTVAAL 76
Cdd:COG0346    7 TLRVSDLEASLAFYTDVLGLELVKRtdfgdggfGHAFLRLGDGTELELFEAPGaapAPGGGGLHHLAFRVDDLDAAYARL 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 736648571  77 RERGVAFERYAGTpvetdddfvfRGGGPLIAWFTDPAGNVLSIIQDDDA 125
Cdd:COG0346   87 RAAGVEIEGEPRD----------RAYGYRSAYFRDPDGNLIELVEPPPG 125
VOC_like cd07264
uncharacterized subfamily of vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate ...
 11-119 7.07e-11

uncharacterized subfamily of vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.


Pssm-ID: 319925 [Multi-domain]  Cd Length: 118  Bit Score: 55.03  E-value: 7.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736648571  11 VDDVDAARRFYADDLGLTVSG--DDMLWLEI-GGGARVLVYPKGEAH------APASFTVLNFPVADVPGTVAALRERGV 81
Cdd:cd07264    8 VDDFAASLRFYRDVLGLPPRFlhEEGEYAEFdTGETKLALFSRKEMArsggpdRRGSAFELGFEVDDVEATVEELVERGA 87

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 736648571  82 AFERyaGTPVETDddfvfrggGPLIAWFTDPAGNVLSI 119
Cdd:cd07264   88 EFVR--EPANKPW--------GQTVAYVRDPDGNLIEI 115
Glyoxalase pfam00903
Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily;
11-119 1.46e-05

Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily;


Pssm-ID: 395724 [Multi-domain]  Cd Length: 121  Bit Score: 41.28  E-value: 1.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736648571   11 VDDVDAARRFYADDLGLTVSGD---------DMLWLEIGGGARVLVYPKGEAHAPASFTVLNFP-----VADVPGTVAAL 76
Cdd:pfam00903   9 VGDLEKSLDFYTDVLGFKLVEEtdageegglRSAFFLAGGRVLELLLNETPPPAAAGFGGHHIAfiafsVDDVDAAYDRL 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 736648571   77 RERGVAFERYAGTpvetdddfvfRGGGPLIAWFTDPAGNVLSI 119
Cdd:pfam00903  89 KAAGVEIVREPGR----------HGWGGRYSYFRDPDGNLIEL 121
 
Name Accession Description Interval E-value
GloA COG0346
Catechol 2,3-dioxygenase or related enzyme, vicinal oxygen chelate (VOC) family [Secondary ...
 8-125 7.19e-15

Catechol 2,3-dioxygenase or related enzyme, vicinal oxygen chelate (VOC) family [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440115 [Multi-domain]  Cd Length: 125  Bit Score: 65.78  E-value: 7.19e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736648571   8 GFSVDDVDAARRFYADDLGLTVSGD--------DMLWLEIGGGARVLVYPKGE---AHAPASFTVLNFPVADVPGTVAAL 76
Cdd:COG0346    7 TLRVSDLEASLAFYTDVLGLELVKRtdfgdggfGHAFLRLGDGTELELFEAPGaapAPGGGGLHHLAFRVDDLDAAYARL 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 736648571  77 RERGVAFERYAGTpvetdddfvfRGGGPLIAWFTDPAGNVLSIIQDDDA 125
Cdd:COG0346   87 RAAGVEIEGEPRD----------RAYGYRSAYFRDPDGNLIELVEPPPG 125
VOC COG3324
Lactoylglutathione lyase-related enzyme, vicinal oxygen chelate (VOC) family [General function ...
 9-124 5.12e-13

Lactoylglutathione lyase-related enzyme, vicinal oxygen chelate (VOC) family [General function prediction only];


Pssm-ID: 442553 [Multi-domain]  Cd Length: 119  Bit Score: 60.80  E-value: 5.12e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736648571   9 FSVDDVDAARRFYADDLGLTV-----SGDDMLWLEIGGGARVLVYPKGEAHAPASfTVLNFPVADVPGTVAALRERGVAF 83
Cdd:COG3324   10 LPVDDLERAKAFYEEVFGWTFeddagPGGDYAEFDTDGGQVGGLMPGAEEPGGPG-WLLYFAVDDLDAAVARVEAAGGTV 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 736648571  84 ERyagtpvetdDDFVFRGGGpLIAWFTDPAGNVLSIIQDDD 124
Cdd:COG3324   89 LR---------PPTDIPPWG-RFAVFRDPEGNRFGLWQPAA 119
VOC_like cd07264
uncharacterized subfamily of vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate ...
 11-119 7.07e-11

uncharacterized subfamily of vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.


Pssm-ID: 319925 [Multi-domain]  Cd Length: 118  Bit Score: 55.03  E-value: 7.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736648571  11 VDDVDAARRFYADDLGLTVSG--DDMLWLEI-GGGARVLVYPKGEAH------APASFTVLNFPVADVPGTVAALRERGV 81
Cdd:cd07264    8 VDDFAASLRFYRDVLGLPPRFlhEEGEYAEFdTGETKLALFSRKEMArsggpdRRGSAFELGFEVDDVEATVEELVERGA 87

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 736648571  82 AFERyaGTPVETDddfvfrggGPLIAWFTDPAGNVLSI 119
Cdd:cd07264   88 EFVR--EPANKPW--------GQTVAYVRDPDGNLIEI 115
VOC_like cd07263
uncharacterized subfamily of vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate ...
 11-121 1.37e-10

uncharacterized subfamily of vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping


Pssm-ID: 319924 [Multi-domain]  Cd Length: 120  Bit Score: 54.61  E-value: 1.37e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736648571  11 VDDVDAARRFYADDLGLTVSGD----DMLWLEIG----GGARVLVYPKG-EAHAPASFTV------LNFPVADVPGTVAA 75
Cdd:cd07263    6 VDDQDKALDFYVEKLGFEVVEDvpmgGMRWVTVAppgsPGTSLLLEPKAhPAQMPQSPEAaggtpgILLATDDIDATYER 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 736648571  76 LRERGVAFeryaGTPVETDddfvfrgGGPLIAWFTDPAGNVLSIIQ 121
Cdd:cd07263   86 LTAAGVTF----VQEPTQM-------GGGRVANFRDPDGNLFALME 120
CatE COG2514
Catechol-2,3-dioxygenase [Secondary metabolites biosynthesis, transport and catabolism];
8-125 2.81e-09

Catechol-2,3-dioxygenase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442004 [Multi-domain]  Cd Length: 141  Bit Score: 51.50  E-value: 2.81e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736648571   8 GFSVDDVDAARRFYADDLGLTVSG--DDMLWLEIGGG-ARVLVYPKGEAHAPASFTVLNF------PVADVPGTVAALRE 78
Cdd:COG2514    8 TLRVRDLERSAAFYTDVLGLEVVEreGGRVYLRADGGeHLLVLEEAPGAPPRPGAAGLDHvafrvpSRADLDAALARLAA 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 736648571  79 RGVAFERYAgtpvetdDDFVFRGggpliAWFTDPAGNVLSIIQDDDA 125
Cdd:COG2514   88 AGVPVEGAV-------DHGVGES-----LYFRDPDGNLIELYTDRPR 122
VOC cd06587
vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate (VOC) superfamily is composed ...
 8-117 4.10e-08

vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). Type I extradiol dioxygenases catalyze the incorporation of both atoms of molecular oxygen into aromatic substrates, which results in the cleavage of aromatic rings. They are key enzymes in the degradation of aromatic compounds. Type I extradiol dioxygenases include class I and class II enzymes. Class I and II enzymes show sequence similarity; the two-domain class II enzymes evolved from a class I enzyme through gene duplication. Glyoxylase I catalyzes the glutathione-dependent inactivation of toxic methylglyoxal, requiring zinc or nickel ions for activity. The antibiotic resistance proteins in this family use a variety of mechanisms to block the function of antibiotics. Bleomycin resistance protein (BLMA) sequesters bleomycin's activity by directly binding to it. Whereas, three types of fosfomycin resistance proteins employ different mechanisms to render fosfomycin inactive by modifying the fosfomycin molecule. Although the proteins in this superfamily are functionally distinct, their structures are similar. The difference among the three dimensional structures of the three types of proteins in this superfamily is interesting from an evolutionary perspective. Both glyoxalase I and BLMA show domain swapping between subunits. However, there is no domain swapping for type 1 extradiol dioxygenases.


Pssm-ID: 319898 [Multi-domain]  Cd Length: 112  Bit Score: 47.90  E-value: 4.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736648571   8 GFSVDDVDAARRFYADDLGLTVSGDD------MLWLEIGGGARVLVYPKGEAHAPASFTVLNFPVADVPGTVAALRERGV 81
Cdd:cd06587    3 ALRVPDLDASVAFYEEVLGFEVVSRNegggfaFLRLGPGLRLALLEGPEPERPGGGGLFHLAFEVDDVDEVDERLREAGA 82

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 736648571  82 AFERYAGTPVEtdddfvfrGGGPLIAWFTDPAGNVL 117
Cdd:cd06587   83 EGELVAPPVDD--------PWGGRSFYFRDPDGNLI 110
SgaA_N_like cd07247
N-terminal domain of Streptomyces griseus SgaA and similar domains; SgaA suppresses the growth ...
 9-121 6.36e-06

N-terminal domain of Streptomyces griseus SgaA and similar domains; SgaA suppresses the growth disturbances caused by high osmolarity and a high concentration of A-factor, a microbial hormone, during the early growth phase in Streptomyces griseus. A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) controls morphological differentiation and secondary metabolism in Streptomyces griseus. It is a chemical signaling molecule that at a very low concentration acts as a switch for yellow pigment production, aerial mycelium formation, streptomycin production, and streptomycin resistance. The structure and amino acid sequence of SgaA are closely related to a group of antibiotics resistance proteins, including bleomycin resistance protein, mitomycin resistance protein, and fosfomycin resistance proteins. SgaA might also function as a streptomycin resistance protein.


Pssm-ID: 319911 [Multi-domain]  Cd Length: 114  Bit Score: 42.25  E-value: 6.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736648571   9 FSVDDVDAARRFYADDLGLTV-----SGDDMLWLEIGGGARVLVYPKGEAHAPA-SFTVLNFPVADVPGTVAALRERGva 82
Cdd:cd07247    6 LPTTDLERAKAFYGAVFGWTFedegdGGGDYALFTAGGGAVGGLMRAPEEVAGApPGWLIYFAVDDLDAALARVEAAG-- 83

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 736648571  83 feryaGTPVETDDDFvfrGGGPLIAWFTDPAGNVLSIIQ 121
Cdd:cd07247   84 -----GKVVVPPTDI---PGGGRFAVFADPEGNRFGLWS 114
Glyoxalase pfam00903
Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily;
11-119 1.46e-05

Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily;


Pssm-ID: 395724 [Multi-domain]  Cd Length: 121  Bit Score: 41.28  E-value: 1.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736648571   11 VDDVDAARRFYADDLGLTVSGD---------DMLWLEIGGGARVLVYPKGEAHAPASFTVLNFP-----VADVPGTVAAL 76
Cdd:pfam00903   9 VGDLEKSLDFYTDVLGFKLVEEtdageegglRSAFFLAGGRVLELLLNETPPPAAAGFGGHHIAfiafsVDDVDAAYDRL 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 736648571   77 RERGVAFERYAGTpvetdddfvfRGGGPLIAWFTDPAGNVLSI 119
Cdd:pfam00903  89 KAAGVEIVREPGR----------HGWGGRYSYFRDPDGNLIEL 121
VOC_like cd08354
uncharacterized subfamily of vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate ...
 11-119 6.48e-05

uncharacterized subfamily of vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.


Pssm-ID: 319942  Cd Length: 122  Bit Score: 39.66  E-value: 6.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736648571  11 VDDVDAARRFYADDLGLT--VSGDDMLWLEIGGGARVLVYPKGEAHAPASFTVlnfPVADVPGTV----AALRERGVAFE 84
Cdd:cd08354    8 ADDLDAAEAFYEDVLGLKpmLRSGRHAFFRLGPQVLLVFDPGATSKDVRTGEV---PGHGASGHGhfafAVPTEELAAWE 84

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 736648571  85 RY---AGTPVEtddDFVFRGGGPLIAWFTDPAGNVLSI 119
Cdd:cd08354   85 ARleaKGVPIE---SYTQWPEGGKSLYFRDPAGNLVEL 119
PhnB COG2764
Zn-dependent glyoxalase, PhnB family [Energy production and conversion];
9-122 1.10e-04

Zn-dependent glyoxalase, PhnB family [Energy production and conversion];


Pssm-ID: 442048 [Multi-domain]  Cd Length: 118  Bit Score: 38.68  E-value: 1.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736648571   9 FSVDDVDAARRFYADDLGLTV-----SGDDMLW---LEIGGGaRVLVY--PKGEAHAPASFTVLNFPVADVPGTVAALRE 78
Cdd:COG2764    6 LVVDDAEEALEFYEDVFGFEVvfrmtDPDGKIMhaeLRIGGS-VLMLSdaPPDSPAAEGNGVSLSLYVDDVDALFARLVA 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 736648571  79 RGvaferyaGTPVETDDDFVFrggGPLIAWFTDPAGNVLSIIQD 122
Cdd:COG2764   85 AG-------ATVVMPLQDTFW---GDRFGMVRDPFGVLWMINTP 118
Glyoxalase_4 pfam13669
Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily;
8-99 2.24e-03

Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily;


Pssm-ID: 463951 [Multi-domain]  Cd Length: 109  Bit Score: 35.33  E-value: 2.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736648571    8 GFSVDDVDAARRFYADDLGLTVSGD--------DMLWLEIGGGARV--LVYPKGEAHAPA----SFTVLNFPVADVPGTV 73
Cdd:pfam13669   4 GIAVPDLDRALALWGALLGLGPEGDyrsepqnvDLAFALLGDGPVEveLIQPLDGDSPLArhgpGLHHLAYWVDDLDAAV 83

                          90       100
                  ....*....|....*....|....*.
gi 736648571   74 AALRERGVAFERYAGTPVETDDDFVF 99
Cdd:pfam13669  84 ARLLDQGYRVAPKGPRAGAAGRRVAF 109
Glyoxalase_6 pfam18029
Glyoxalase-like domain; This entry comprises a diverse set of domains related to the ...
 9-120 3.13e-03

Glyoxalase-like domain; This entry comprises a diverse set of domains related to the Glyoxalase domain. The exact specificity of these proteins is uncertain.


Pssm-ID: 436220  Cd Length: 110  Bit Score: 34.66  E-value: 3.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736648571    9 FSVDDVDAARRFYADDLGLTVSGDDMLWLE------IGGGARVLVYPKGEAHAPASFTV-LNFPVADVPGTVAALRERGv 81
Cdd:pfam18029   4 LDCADPAALAAFWSAALGWEVVPDDTALPDpdgggpIGGGGPRLLFQRVPEPKPGKNRVhLDLAVDDLEAAVARLVALG- 82

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 736648571   82 aferyaGTPVETDDDFVFRGGGpliawFTDPAGNVLSII 120
Cdd:pfam18029  83 ------ATVLDDGDDPDGGRWV-----LADPEGNEFCLV 110
VOC_Bs_YwkD_like cd08352
vicinal oxygen chelate (VOC) family protein Bacillus subtilis YwkD and similar proteins; ...
 13-114 4.98e-03

vicinal oxygen chelate (VOC) family protein Bacillus subtilis YwkD and similar proteins; uncharacterized subfamily of vicinal oxygen chelate (VOC) family contains Bacillus subtilis YwkD and similar proteins. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.


Pssm-ID: 319940 [Multi-domain]  Cd Length: 123  Bit Score: 34.44  E-value: 4.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736648571  13 DVDAARRFYADDLGLTV--------SGDDMLWLEIGGG-----------ARvLVYPkgEAhapASFTVLNFPVADVPGTV 73
Cdd:cd08352   12 DYEKSKDFYVDKLGFEIirehyrpeRNDIKLDLALGGYqlelfikpdapAR-PSYP--EA---LGLRHLAFKVEDVEATV 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 736648571  74 AALRERGVAFEryagtPVETDD----DFVFrgggpliawFTDPAG 114
Cdd:cd08352   86 AELKSLGIETE-----PIRVDDftgkKFTF---------FFDPDG 116
COG3607 COG3607
Lactoylglutathione lyase-related enzyme, vicinal oxygen chelate (VOC) family [General function ...
 11-121 6.03e-03

Lactoylglutathione lyase-related enzyme, vicinal oxygen chelate (VOC) family [General function prediction only];


Pssm-ID: 442825  Cd Length: 126  Bit Score: 34.03  E-value: 6.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736648571  11 VDDVDAARRFYAdDLGLTV----SGDDMLWLEIGGGARVLVYPK-----------GEAHAPASFTV-LNFP-VADVPGTV 73
Cdd:COG3607   11 VADLERSRAFYE-ALGFTFnpqfSDEGAACFVLGEGIVLMLLPRekfatftgkpiADATGFTEVLLaLNVEsREEVDALV 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 736648571  74 AALRERGvaferyaGTPV-ETDDDFVFRGGGpliawFTDPAGNVLSIIQ 121
Cdd:COG3607   90 AKALAAG-------GTVLkPPQDVGGMYSGY-----FADPDGHLWEVAW 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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